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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.01.092 Byline: Tally Levy, Abraham Golan, Joseph Menczer Abstract: This study was undertaken to assess the natural course of endometrial endometrioid carcinoma by identifying untreated patients and those with a prolonged (>6 months) treatment delay. Author Affiliation: Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel; Tel Aviv University, Faculty of Medicine, Tel Aviv, Israel Article History: Received 11 December 2005; Accepted 20 January 2006 Article Note: (footnote) Reprints not available from the authors.

The natural course of endometrial endometrioid carcinoma is assessed by identifying untreated patients and those with a prolonged treatment delay. The lengthy survival of these patients has indicated that the natural progression course, even in untreated patients, might be slow in endometrial carcinoma with favorable prognostic factors.

In ectopic or extrauterine pregnancies, the fertilized egg implants in tissues other than the uterus. Implantation in the ovary is one of the rarest of ectopic pregnancies and is difficult to diagnose. The symptoms, diagnosis, and treatment of 20 cases of ovarian pregnancy are described in this article. The ovarian pregnancies represented 3.3 percent of all ectopic pregnancies at one institution during a 19-year period, a rate similar to that reported in the literature. However, the prevalence in this group increased during the later years. Eighteen of 20 patients used the intrauterine device (IUD) for contraception. Abdominal pain and menstrual irregularity were the most frequently reported symptoms. Ovarian pregnancy leads to increased growth of blood vessels in the ovary, with associated rupture in many cases. Circulatory collapse due to loss of blood occurred in six patients. Thirteen of the 20 cases were suspected of having ectopic pregnancy before surgery, while other ovarian or abdominal disorders were suspected in the rest. Among eight fertile patients who did not continue contraceptive use and who were available for follow-up study, seven had normal pregnancies and one had an ectopic pregnancy which occurred in the fallopian tubes. Ovarian pregnancies may be associated with IUD use because IUDs (untreated with copper or progesterone) may effectively prevent only uterine and tubal pregnancies. (Consumer Summary produced by Reliance Medical Information, Inc.)

Two methods of treating intact tubal pregnancies, salpingostomy and methotrexate injections into the growing cells, appear to be equally safe and effective. Salpingostomy is a surgical procedure to widen the fallopian tube and remove the pregnancy. Forty-eight intact tubal pregnancies were removed with either salpingostomy or methotrexate. The group treated by salpingostomy were in surgery longer but in the hospital a shorter amount of time than those treated with methotrexate. Eighty-one percent of the methotrexate group and 83.5% of the salpingostomy group later had normal pregnancies.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2010.01.012 Byline: Michal Kovo (a), Letizia Schreiber (b), Avi Ben-Haroush (c), Suzanna Wand (a), Abraham Golan (a), Jacob Bar (a) Keywords: fetal growth restriction; hypertension; placenta; under-perfusion; villous lesion Abstract: Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders. Author Affiliation: (a) Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel (b) Department of Pathology, Edith Wolfson Medical Center, Holon, Israel (c) Rabin Medical Center, Petah-Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Article History: Received 12 July 2009; Revised 20 October 2009; Accepted 12 January 2010 Article Note: (footnote) Cite this article as: Kovo M, Schreiber L, Ben-Haroush A, et al. Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction. Am J Obstet Gynecol 2010;202:561.e1-5. , Authorship and contribution to the article is limited to the 6 authors indicated. There was no outside funding or technical assistance with the production of this article., The first 2 authors contributed equally to this article.

Women who have large uterine fibroid tumors frequently have symptoms suggesting pressure on the urinary bladder, including increased frequency and urgency, and incontinence. Medical opinion is varied as to whether removal of the tumor relieves the symptoms, whether surgery, which removes the nerve stimulation and regulation of the bladder, exacerbates the problems, or whether urinary symptoms are not related to tumor pressure on the bladder. The relationship between tumor size and urinary symptoms was evaluated in 14 women who were treated with hormonal rather than surgical therapy. Gonadotropin-releasing hormone (GnRH), which decreases estrogen secretion, shrinks fibroid tumors, which are estrogen-dependent. The women were aged 39 to 50 and had given birth to between one and four children. Following two months of treatment with GnRH, tumors shrank in size by more than half. This was associated with significant decreases in nocturnal urination, urgency, and frequency in urination during the day. Decreased uterine size did not alter urge incontinence or stress incontinence. Measurements of bladder function such as capacity and pressure rise on filling did not change in response to treatment. The results support the idea that pressure on the bladder caused by uterine fibroid tumors are responsible for urinary difficulties. (Consumer Summary produced by Reliance Medical Information, Inc.)

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.08.031 Byline: Samuel Lurie (1)(3)(4), Miri Eliaz (4), Mona Boaz (2)(4), Tally Levy (1)(4), Abraham Golan (1)(4), Oscar Sadan (1)(4) Keywords: cervical intraepithelial neoplasia; colposcopy; lesion location Abstract: This study was undertaken to assess the validity of an assumption that histologically confirmed cervical intraepithelial neoplasia (CIN) lesions are not randomly distributed across the cervix. Author Affiliation: (1) Department of Obstetrics & Gynecology, Edith Wolfson Medical Center, Holon (2) Epidemiology and Research Unit, Edith Wolfson Medical Center, Holon (3) Cervical Unit, Woman's Health Center, 'Netka,' (4) Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Article History: Received 18 February 2006; Revised 10 June 2006; Accepted 8 August 2006 Article Note: (footnote) Reprints not available from authors. Cite this article as: Lurie S, Eliaz M, Boaz M, et al. Distribution of cervical intraepithelial neoplasia across the cervix is random. Am J Obstet Gynecol 2007;196:125.e1-125.e3.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.07.050 Byline: Joseph Menczer (a), Letizia Schreiber (b), Bernard Czernobilsky (c), Esther Berger (b), Abraham Golan (a), Tally Levy (a)(b)(c) Keywords: germ cell tumor; granulosa cell tumor; Her-2/neu Abstract: The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. Author Affiliation: (a) Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel (b) Department of Pathology, Tel Aviv University, Faculty of Medicine, Tel Aviv, Israel (c) Patho-Lab Laboratories, Nes-Ziona, Israel. Article History: Received 23 March 2006; Revised 5 June 2006; Accepted 6 July 2006 Article Note: (footnote) The contribution of both first authors was equal., Cite this article as: Menczer J, Schreiber L, Czernobilsky B, et al. Is Her-2/neu expressed in nonepithelial ovarian malignancies? Am J Obstet Gynecol 2007;196:79.e1-79.e4