1. Systematic exploration of the pH dependence of a peptide hydrogel
- Author
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Falcone, Natashya, Shao, Tsuimy, Sun, Xiaoyi, and Kraatz, Heinz-Bernhard
- Subjects
Biological products -- Research ,Amino acids -- Research ,Hydrogen-ion concentration -- Research ,Peptides -- Research ,Chemistry ,University of Toronto - Abstract
Stimuli-responsive peptide gels are a growing class of functional biomaterials that are involved in many applications in research. Here, we present a novel di-peptide hydrogel from the compound Boc--Phe--Trp--OH in various buffer and pH conditions. We examine the effects of different stimuli, including temperature and pH, on the mechanical strength of the gels through frequency rheology studies. We found that this hydrogelator is highly pH dependent, only forming a gel in a narrow range of pH 6-7. This hydrogelator hold promise for the development of new stimuli-responsive biomaterials for specific applications that require this type of specific stimuli. Key words: hydrogel, peptides, stimuli responsive, pH-dependent gelation, rheology. Les gels peptidiques stimulables constituent une classe grandissante de biomateriaux fonctionnels mis a contribution dans de nombreuses applications en recherche. Dans le present article, nous faisons etat d'un nouvel hydrogel dipeptidique produit a partir du compose Boc--Phe--Trp--OH dans divers tampons et conditions de pH. Nous examinons les effets de differents stimuli, tels que la temperature et le pH, sur la resistance mecanique des gels au moyen d'etudes de rheologie frequentielle. Nos resultats ont montre que ce gelifiant est tres sensible au pH, formant un hydrogel dans un intervalle de pH etroit (pH 6-7). Ce gelifiant constitue une avenue prometteuse pour la mise au point de nouveaux biomateriaux stimulables destines a des applications particulieres necessitant ce type de stimuli tres precis. [Traduit par la Redaction] Mots-cles : hydrogel, peptides, stimulable, gelification sensible au pH, rheologie., Introduction Peptide-based supramolecular gels are functional materials that have been the subject of research due to their versatility and their wide range of applications in many fields. (1) They can [...]
- Published
- 2019
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