1. Tissue distribution of transplanted fetal liver cells in the human fetal recipient
- Author
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Westgren, Magnus, Ek, Sverker, Bui, TheHung, Jansson, Berit, Kjaeldgaard, Anders, Markling, Lola, Nennesmo, Inger, Seiger, Ake, Sarby, Bertil, Thornstrom, Stig, and Ringden, Olle
- Subjects
Liver -- Transplantation ,Fetal tissue transplantation -- Methods ,Fetus -- Physiological aspects ,Health - Abstract
Fetal liver cell transplants may be more likely of being engrafted in the host fetus's liver if they are injected into the heart rather than into the abdomen. The heart or abdomen of 10 normal fetuses scheduled for prostaglandin abortions were injected with radiolabeled fetal liver cells under ultrasonographic guidance. After abortion, the levels of fetal liver cells were compared in various fetal organs. Injections into the heart were associated with higher levels of fetal liver cells in the liver, spleen, thymus, kidney, lung, and placenta. Fetal liver cell transplants may treat fetal immune deficiencies.
- Published
- 1997