1. Function of mitochondrial Stat3 in cellular respiration
- Author
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Wegrzyn, Joanna, Potla, Ramesh, Chwae, Yong-Joon, Sepuri, Naresh B.V., Zhang, Qifang, Koeck, Thomas, Derecka, Marta, Szczepanek, Karol, Szelag, Magdalena, Gornicka, Agnieszka, Moh, Akira, Moghaddas, Shadi, Chen, Qun, Bobbili, Santha, Cichy, Joanna, Dulak, Jozef, Baker, Darren P., Wolfman, Alan, Stuehr, Dennis, Hassan, Medhat O., Fu, Xin-Yuan, Avadhani, Narayan, Drake, Jennifer I., Fawcett, Paul, Lesnefsky, Edward J., and Larner, Andrew C.
- Subjects
Respiration -- Research ,Cell physiology -- Research ,Cellular proteins -- Properties ,Mitochondria -- Properties ,Science and technology - Abstract
Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured ceils and primary tissues, including the liver and heart. In [Stat3.sup.-/-] cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
- Published
- 2009