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The increasing prevalence and complications related to liver diseases (caused by infection, toxic agents, or metabolic syndrome), together with insufficient existence of treatments, make evident the need for better therapeutic alternatives. Therefore, the aim of this study was to determine the effect of 4-hydroxychalcone (4-HC) as preventive and curative treatment in acute and chronic liver injury, respectively. Liver damage was induced with carbon tetrachloride (C[Cl.sub.4]) in Wistar rats. Rats were divided into two groups: (1) acute liver injury and (2) chronic liver injury. In turn, each group was divided into four subgroups: (i) control (water); (ii) dimethyl sulfoxide 10%; (iii) C[Cl.sub.4]; and (iv) 4-HC. The pre-treatment with 4-HC decreased transaminases, IL-6 serum levels, and hepatic malondialdehyde, increased IL-10 serum levels and hepatic glutathione, and decreased liver damage (necrosis, steatosis, and inflammatory infiltrate). In contrast, treatment with 4-HC after the induction of chronic liver injury decreased IL-6 serum levels and liver damage (steatosis, inflammatory infiltrate, ballooning cells, steatofibrosis, and fibrosis degree). Thus, the 4-HC treatment is proposed as a preventive treatment against acute liver injury; moreover, these results suggested the potential of 4-HC as a curative treatment against chronic liver injury, but other scheme treatments must be evaluated in future. Key words: 4-hydroxychalcone, fibrosis, steatosis, acute liver injury, chronic liver injury, preventive treatment, curative treatment L'augmentation de la prevalence des maladies hepatiques et des complications qui y sont liees (causees par l'infection, les agents toxiques ou le syndrome metabolique), de meme que de traitements existants insuffisants, mettent en evidence le besoin de meilleurs choix d'options therapeutiques. Par consequent, cette etude avait pour but d'etablir l'effet de la 4hydroxychalcone (4-HC) en tant que traitement preventif et curatif de l'insuffisance hepatique aigue et chronique, respectivement. Nous avons obtenu des dommages hepatiques a l'aide de tetrachlorure de carbone (CCl4]) chez des rats Wistar. Nous avons reparti les rats dans deux groupes : (1) insuffisance hepatique aigue et (2) insuffisance hepatique chronique. Ensuite, nous avons reparti les rats de chacun des groupes dans quatre sous-groupes : (i) temoin (eau); (ii) dimethylsulfoxyde a 10 %; (iii) CCl4; et (iv) 4-HC. L'administration prealable de 4-HC a entraine un abaissement des transaminases, des taux seriques d'IL-6 et de malondialdehyde hepatique, ainsi qu'une hausse des taux seriques d'IL-10 et de glutathion hepatique, avec une attenuation des lesions hepatiques (necrose, steatose et infiltrats inflammatoires). Par ailleurs, l'administration de 4-HC apres la production d'une insuffisance hepatique chronique a entraine un abaissement des taux seriques d'IL-6 et une attenuation des dommages hepatiques (steatose, infiltrats inflammatoires, gonflement cellulaire, steatofibrose et degre de fibrose). Par consequent, nous proposons l'administration de 4-HC comme traitement preventif contre l'insuffisance hepatique aigue. En outre, ces resultats laissent entrevoir le potentiel de l'administration de 4-HC comme traitement curatif contre l'insuffisance hepatique chronique. Cependant, d'autres schemas therapeutiques devront etre evalues dans le futur. [Traduit par la Redaction] Mots-cles : 4-hydroxychalcone, fibrose, steatose, insuffisance hepatique aigue, insuffisance hepatique chronique, Traitement preventif, traitement curatif, Introduction The liver is affected by different infection diseases (mainly hepatitis B and C), toxic agents (alcohol abuse and drugs), and metabolic syndromes (e.g., non-alcoholic steatohepatitis, NASH) (Crespo Yanguas et [...]

The nanche de la costa (Zizyphus sonorensis) fruit was partially characterized by physicochemical and nutritional analyses. This fruit has a homogenous size and color and low moisture content (47 g/100 g). The content of tannins and nickel of the edible portion might limit its use. However, nanche de la costa has important characteristics and potential to be considered as a food or feed source. The remarkable characteristics of the edible portion are high content of total (35 g/100 g) and soluble (0.6 g/100 g) dietary fiber, high level of copper (0.53 mg/100 g), iron (10 mg/100 g) and zinc (4.2 mg/100 g). The seed was distinguished by its high content of total dietary fiber (82.1 g/100 g), calcium (540 mg/100 g), copper (0.54 mg/100 g), chromium (1.1 mg/100 g) and zinc (4.5 mg/100 g). The moisture value is given in fresh weight basis and all other values are in dry weight basis. Keywords: Fruit, nutritional characteristics, physicochemical characteristics, Zizyphus sonorensis