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OBJECTIVE--Insulin degludec/insulin aspart (IDegAsp) is a soluble coformulation of the novel basal analog insulin degludec (IDeg: 70%) and insulin aspart (IAsp: 30%). We compared the safety and efficacy of IDegAsp, [...]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2005.07.054 Byline: Jaime Davidson Keywords: Adherence; Barriers; Frequency; Hypoglycemia; Implementation; Self-monitoring of blood glucose Abstract: Despite the increasing prevalence of diabetes, improved understanding of the disease, and a variety of new medications, glycemic control does not appear to be improving. Self-monitoring of blood glucose (SMBG) is one strategy for improving glycemic control; however, patient adherence is suboptimal and proper education and follow-up are crucial. Patients need to understand why they are being asked to self-test, what their glycemic targets are, and what they should do based on the results of self-monitoring. Patients also must be taught proper technique and must be given specific recommendations regarding frequency and timing for self-monitoring. Situations in which SMBG is essential or should be more frequent include self-adjustment of insulin doses, changes in medications, lack of awareness of hypoglycemia, gestational diabetes, illness, or when hemoglobin A.sub.1c (HbA.sub.1c) values are above target. SMBG should include postprandial monitoring to identify glycemic excursions after meals, to indicate the need for lifestyle adjustments, and to provide patient feedback on dietary choices. Author Affiliation: University of Texas Southwestern Medical School, and Endocrine and Diabetes Associates of Texas, Dallas, Texas, USA Article Note: (footnote) Publication of this article was made possible through editorial support from Health Learning Systems and an educational grant from LifeScan, Inc.

Prediabetes is defined by the presence of impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). In 2003, an international expert committee on the diagnosis and classification of diabetes mellitus [...]

New-onset diabetes and impaired glucose tolerance (IGT) are among the most serious metabolic complications of solid organ transplantation. Despite the importance of these conditions to the outcome of transplant recipients, [...]

OBJECTIVE -- To compare the safety and efficacy of insulin aspart (IAsp), buffered regular insulin (BR), and insulin lispro administered by continuous subcutaneous insulin infusion (CSII) in patients with type [...]

Given that cardiovascular disease is a common complication of diabetes (1) and the leading cause of death among people with diabetes (2,3), it is important that we use the most [...]

Universal screening for diabetes mellitus is not recommended, but testing high-risk groups can lead to earlier diagnoses and interventions that may forestall complications. ARTICLE CONSULTANTS JAIME A. DAVIDSON, MD clinical [...]

In August 2001, the American College of Endocrinology (ACE) published its recommendations for glycemic targets in the management of diabetes. Included in those recommendations was a target for 2-h postprandial [...]

Prediabetes is defined by the presence of impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). In 2003, an international expert committee on the diagnosis and classification of diabetes mellitus [...]

Combination therapy with metformin (Met) and glyburide (Gly) is often used to treat patients with type 2 diabetes. Met is associated with gastrointestinal (GI) symptoms, and Gly may cause hypoglycemia. [...]

Metformin (Met) and glyburide (Gly) are often used in combination to treat patients with type 2 diabetes. A fixed combination metformin/glyburide (M/G) tablet has been developed and evaluated in clinical [...]

The pathogenesis of type 2 diabetes involves both impaired insulin secretion and increased insulin resistance. Use of two oral antidiabetic agents with complementary mechanisms of action may result in a [...]

Type 2 diabetes results from the dual defects of insulin resistance and progressive inadequacy of pancreatic insulin secretion. Traditional first-line therapy has focused on the management of one or the [...]

Once only the bane of middle age, type 2 diabetes is becoming a disease of increasingly obese, inactive, younger adults. To halt the ravages of type 2 diabetes, which has [...]

Response to Nathan et al. We applaud the efforts of those who developed the American Diabetes Association/European Association for the Study of Diabetes algorithm for managing type 2 diabetes (1). [...]

Response to Kilpatrick et al. In an analysis of the datasets collected in the Diabetes Control and Complications Trial, Kilpatrick et al. (1) reported that mean blood glucose was predictive [...]

CASE A 40-year-old black female with a history of bipolar disorder is brought to the emergency department (ED) because of progressive obtundation. For the past few days she has experienced [...]

CASE A 35-year-old white female without a significant medical history is admitted to the hospital with symptoms of polyuria, polydipsia, abdominal pain, a blood glucose level of 483 mg/dL, and [...]

CASE A 59-year-old white male is referred for endocrine consultation by his cardiologist after having coronary angioplasty. Diabetes had been diagnosed six years earlier. He was treated initially with glyburide, [...]