Author: "Chen, Xin-sheng" / Database: Gale General OneFile - Searchworks@Jio Institute Digital Library Search Results

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Author: Yu, Ying, Fan, Jinjin, Chen, Xin-Sheng, Wang, Dairong, Klein-Szanto, Andres J, Campbell, Robert L, FitzGerald, Garret A, and Funk, Colin D
Abstract: Author(s): Ying Yu [1]; Jinjin Fan [1]; Xin-Sheng Chen [1, 5]; Dairong Wang [1]; Andres J Klein-Szanto [2]; Robert L Campbell [3]; Garret A FitzGerald [1]; Colin D Funk (corresponding [...]
Published: 2006
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Author: Chen, Xin-Sheng, Sheller, James R., Johnson, Eric N., and Funk, Colin D.
Subjects: Leukotrienes -- Research, Inflammation -- Mediators, Genetic recombination -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Targeted disruption of 5-lipoxygenase gene by homologous recombination in embryonic stem cells establishes the physiological importance of leukotrienes, a class of biological mediators of inflammation and anaphylaxis. The observed 5-lipoxygenase-deficient mice show resistance to the harmful effects of endotoxin shock induced by the platelet-activating factor and confirm that leukotrienes are vital to the pathophysiology of specific inflammatory states. Mast cells release chemotactic leukotrienes that facilitate neutrophil recruitment during early inflammatory insult.
Published: 1994

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