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Your search keyword '"Arnusch, Christopher J."' showing total 2 results
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2 results on '"Arnusch, Christopher J."'

1. The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci

Author

Arnusch, Christopher J., Bonvin, Alexandre M.J.J., Verel, Anne Marie, Jansen, Wouter T.M., Liskamp, Rob M.J., de Kruijff, Ben, Pieters, Roland J., and Breukink, Eefjan

Subjects
Enterococcus -- Physiological aspects, Drug resistance in microorganisms -- Analysis, Vancomycin -- Chemical properties, Vancomycin -- Usage, Biological sciences, Chemistry
Abstract

A hybrid antibiotic consisting of vancomycin and nisin fragments is more active than the separate fragments against vancomycin resistant enterococci (VRE). Three different hybrids are prepared by using click chemistry and optimal spacer lengths and connection points are predicted by using computer modeling.

Published
2008

2. Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides

Author

Arnusch, Christopher J., Branderhorst, Hilbert, de Kruijff, Ben, Liskamp, Rob M.J., Breukink, Eefjan, and Pieters, Roland J.

Subjects
Anti-infective agents -- Research, Cell membranes -- Structure, Magainins -- Chemical properties, Peptides -- Research, Biological sciences, Chemistry
Abstract

Several multivalent-made antimicrobial peptide magainin 2 compounds are examined for their pore-forming capability in large unilamillar vesicles (LUVs). Results show an almost 600-fold enhancement in pore formation by these compounds.

Published
2007

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