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1. ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells

Author

Antic, Dragana, Lu, Ning, and Keene, Jack D.

Subjects
Messenger RNA -- Observations, Cell differentiation -- Genetic aspects, Genetic translation -- Observations, Neurons -- Genetic aspects, Biological sciences
Abstract

The translation and/or stability of AU-rich sequence element (ARE)-containing mRNAs can be independently regulated by the ELAV protein Hel-N1. Hel-N1 is an ELAV tumor antigen that increases translation of neurofilament M mRNA. It also helps neurites form in human teratocarcinoma cells. It appears that turnover of NF-M mRNA was not affected by Hel-N1 expression although Hel-N1 can bind to the 3' UTR of NF-M mRNA. Hel-N1 is directly associated with NF-M mRNA in transfected cells.

Published
1999

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