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Design and Duration: Randomized, double-blind, placebo-controlled trial for eight weeks, preceded by a 4-week run-in period and followed by a 4-week washout period to assess symptoms post-treatment. Participants: 75 volunteers, [...]

The development of a standardized extract of hawthorn leaves and flowers in Europe has led to a novel approach to the treatment of congestive heart failure (CHF). Clinical trials with [...]

Reference: Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil®) in the treatment of irritable bowel smdromc: A prospective, double-blind, placebo-controlled, randomized trial. Digestive Liver Dis 2007;39:530-6. Design: [...]

Reference: Hickson M, D'Souza A, Muthu N, et al. Use of probiotic Lactobacillus preparation to prevent diarrhea associated with antibiotics: randomized double blind placebo controlled trial. BMJ 2007;335:80; doi:10.1136/bmj.39231.599815.55 [Epub]. [...]

Design & Participants: Open-label, single-arm clinical trial of 46 men (ages are not given) with recurrent prostate cancer with rising prostate-specific antigen (PSA) after surgery or radiotherapy. Eligible patients had [...]

Design & Participants: Randomized, double-blind, placebo-controlled trial of 89 patients (ages 13-65 years) with a diagnosis of ulcerative colitis (UC) as confirmed by radiologic, endoscopic, or histological criteria. Patients were [...]

Reference: Imhof M. Gocan A, Reithmyr F, et al. Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women. Maturitas 2006;55:76-81. Design: Randomized, double-blind, placebo-controlled, [...]

Design: Prospective, placebo-controlled, parallel groups study. Participants: 60 adult patients (aged 55-68 years) with diabetes mellitus and severe microangiopathy. All patients had been treated with insulin for at least 3 [...]

Design: Open-label, multicenter trial with 918 children ( Study Medication and Dosage: Euvegal® forte (Dr. Willmar Schwabe Pharmaceuticals, Karlsruhe Germany)--each tablet consisted of 160 mg of valerian (Valeriana officinalis L.) [...]

Design and Duration: Double-blind, randomized, placebo-controlled trial over the course of five days. Participants: 87 children (two months to six years old) with infectious diarrhea. Diarrhea was defined as three [...]

Design and Duration: Double-blind, randomized, placebo-controlled trial over the course of 12 months. Participants: 225 men over the age of 49 years with moderate to severe symptoms of benign prostatic [...]

Design: Open-label study. Participants: Group 1: Five patients (3 women and 2 men, ages 28-54 years) with a diagnosis of ulcerative proctitis (symptoms ranging from 1 to 32 years)--at the [...]

Design: Randomized, double-blind, placebo-controlled, three-month trial of 479 healthy adults (18-67 years old). Study Medication: Test preparations were given in tablets containing vitamins and minerals (exact composition is given in [...]

Design: Randomized, double-blind, parallel groups for four weeks. Participants: 91 atopic, non-smoking adults (ages 18-65 years) with moderate to severe, persistent asthma. Inclusion criteria included: 1) a history of asthma [...]

Design: Randomized, double-blind, placebo-controlled trial with blinded treatment for eight weeks and a final assessment at 16 weeks. Participants: 56 children (6-18 months) with moderate or severe atopic dermatitis (AD). [...]

Summary: A review of case reports was conducted to determine the strength of the data supporting the common assertion that Ginkgo biloba extract (GBE) may cause or increase the risk [...]

Participants: A six-week, multi-center, randomized, double-blind, parallel-group trial was conducted with 96 volunteers (28 men and 70 women, mean age approximately 56.5 years) with radiologically confirmed and symptomatic osteoarthritis (OA) [...]

Participants: A randomized, double-blind, double-dummy, equivalence trial was set up with 251 volunteers (83 men, 168 women) from 21 psychiatric primary care outpatient clinics in Germany, 18-70 years old (median [...]

The development of a standardized extract of the rhizome of butterbur (Petasites hybridus) has led to a new clinical approach to the management of migraine headaches. Two clinical trials with [...]

Reference: Lizogub VG, Riley DS, Heger M. Efficacy of a Pelargonium sidoides preparation in patients with the common cold: A randomized, double-blind, placebo-controlled clinical trial. Explore 2007; 3: 573-84. Design: [...]

Reference: Vuksan V, Sung M, Sievenpiper JL, et al. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled [...]

Reference: Edwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007;137:2405-11. Design: Randomized, double-blind, placebo-controlled, crossover trial Participants: Males and females with [...]

Design & Participants: Randomized, double-blind, placebo-controlled trial of 50 healthy, adult volunteers (19 female and 31 male; mean age of 33 ± 7.7 years) Study Medication & Dosage: One capsule [...]

Design: Randomized, controlled trial Reference: Billoo AG, Memon MA, Khaskheli SA, et al. Role of probiotic (Saccharomyces boulardii) in management and prevention of diarrhea. World J Gatroenterol 2006; 12:4557-60. Participants: [...]

Design and Duration: Randomized, double-blind, placebo-controlled trial with a treatment period of six months followed by a six-month observation period during which patients continued on sulfasalazine or mesalamine. Participants: 89 [...]

Design: Randomized, double-blind, placebo-controlled, multicenter, dose-ranging study Participants: 362 female primary care IBS patients (ages 18-65 years old) who met the Rome II criteria for the diagnosis of IBS (any [...]

Design and duration: Double-blind, randomized, placebo-controlled trial over the course of 16 weeks. Participants: 301 women (ages 45-60 years old) experiencing climacteric complaints (menopausal symptoms) with a 'pronounced psychological component' [...]

Design: Multicenter, randomized, placebo-controlled, double-blind, parallel group trial. Participants: 122 women (ages 45-60 years) in peri- or early postmenopause with climacteric disorders, including ≥ 3 hot flashes per day. Inclusion [...]

Summary: Nine 'healthy' women, ages 22-26 years, received 3.5 g of licorice (Saila, Italy), containing 7.6% W.W. glycyrrhizic acid (0.25 grams total glycyrrhizic acid per day), qd for two months. [...]

Design and Duration: Randomized, comparison trial over 42 days. Participants: 24 'healthy' women, ages 20-39 years (average 26 years) with similar eating behaviors, especially for consumption of fruits and vegetables, [...]