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L'atteinte isolée de l'axe hypothalamo-hypophysaire dans la sarcoïdose est rare. Seulement quelques cas sont rapportés sur la littérature. Nous rapportons l'observation clinique d'une patiente âgée de 50 ans, opérée il y a 4 ans pour goitre avec thyroïdectomie totale sous traitement substitutif. Elle se plaint de céphalées chroniques depuis 6 mois devenues récemment rebelles concomitant avec la survenue d'une baisse de l'acuité visuelle. L'examen clinique retrouve un syndrome opto-chiasmatique avec altération importante du champ visuel. Elle présente aussi une paralysie du nerf occulo-moteur commun à droite avec ptôsis. L'IRM cérébrale a objectivé un processus sellaire de signal tissulaire avec prise de contraste hétérogène et qui s'étend à la tige pituitaire avec épaississement de celle-ci. Le bilan hormonal pré opératoire a retrouvé une légère insuffisance thyréotrope. La patiente a bénéficié d'une exérèse tumorale large par voie transnasale trans-sphénoidale endoscopique d'une tumeur de consistance fibreuse et peu hémorragique. L'évolution post opératoire était marquée par la survenue d'un diabète insipide et d'une fistule de LCR au 2ème jour post opératoire. L'évolution était bonne sous traitement médical avec drainage spinal. Le bilan général n'a pas retrouvé une autre localisation de la sarcoïdose notamment une tomodensitométrie thoraco-abdominale et échographie cardiaque sans particularités. Le dosage de l'enzyme de conversion est revenu normal. La patiente a bénéficié d'une corticothérapie pour le traitement de la maladie systémique. La neurosarcoïdose est un critère de mauvais pronostic chez un patient atteint d'une sarcoïdose. L'atteinte hypothalamo-hypophysaire est rare avec des complications plus fréquentes que les autres atteintes neurologiques et systémiques nécessitant une prise en charge multidisciplinaire à long terme.

BACKGROUND AND OBJECTIVE: As an important achievement in industrialization and urbanization, depression can be much related to the oral hygiene especially periodontal indexes which are a symbol of tooth and oral hygiene and their surrounding tissues. The purpose of this study was to compare the periodontal indexes in individuals with and without depression disorders.METHODS: The present study was carried out in the form of a questionnaire, examination, and recording in the information form. The subjects were divided into two groups of 50 a group included the patients suffering from depression who hospitalized in Neuropsychology ward of Panje Azar hospital in Gorgan, Iran and the control group included either the patients who referred to department of oral medicine and diagnosis of Babol dental school or the people accompanying the patients who had claimed to have no history of depression. The periodontal indexes of the study included: Silness and Loe plaque index, Loe gingival index, pocket depth analysis, as well as bleeding on probing. The information related to each patient was recorded in the form and then two groups were compared.FINDINGS: In the present study, the pocket probing were 2.7692±0.5991 and 2.2917±0.4643 in the control and case groups, respectively (p= 0.009). The Plaque Index means were 1.5385±0.1 and 7763.2593±0.5257 in the control and case groups, respectively. Furthermore, the GI and BOP difference between the two groups were not significant. Moreover, there was no significant relationship between the mean of all the analyzed indexes and the increase of depression.CONCLUSION: The results of the present study indicate a vivid relationship between the depth of pocket probing and depression. Nevertheless, none of the periodontal indexes were obviously related to the degree of depression.Please cite this article as follows:Jenabian N, Taziki SA, Hosseini R, Kiakojouri A, Ehsani H. Comparison of Periodontal Indexes in Individuals with and without Depression Disorders. J Babol Univ Med Sci 2013 15(6):90-94.

In order to determine the time of puerperium when the pituitary- ovarian axis of the suckler zebu cow (Bos indicus) is functional, a single dose of 100 μg synthetic GnRH was injected intramuscularly in 60 suckler zebu cows divided into six groups. The animals were treated 7, 10, 15, 20, 25 and 30 days after parturition. Ten milliliters of milk were sampled from each animal as follows: before GnRH injection (A: 1st sample range), on days 5, 6, 7, 8 (B: 2nd sample range) and 20, 21, 22, 23, 24 (C: 3rd sample range) after GnRH injection. In each group, samples obtained before GnRH injection were used as control. Overall, 600 milk samples were used to determine progesterone concentrations by radioimmunoassay. Among the animals treated with GnRH 15 days after parturition, 60% responded to the treatment with a mean progesterone concentration of 2.67 ± 1.89 nmol/L. This response increased along with the length of the post-partum period. Thirty days after calving, all animals responded well to the treatment (mean progesterone concentration: 4.09 ± 1.09 nmol/L) and presented a significant reduction (p < 0.05) in the interval from calving to conception compared to animals treated on days 7 and 10 after calving. This study shows that, as early as 15 days post-partum, the pituitary-ovarian axis of suckler zebu cows is sensitive to exogenous GnRH and that such treatment may improve reproductive performances.