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The raindrop method of searching a solution space for feasible and efficient forest management plans has been demonstrated as being useful under a limited set of circumstances, mainly where adjacency restrictions are accommodated using the unit restriction model. We expanded on this work and applied the model (in a modified form) to a problem that had both wood flow and area restriction adjacency constraints, then tested the problem formulation on six hypothetical forests of different sizes and age class distributions. Threshold accepting and tabu search were both applied to the problems as well. The modified raindrop methodâs performance was best when applied to forests with normal age class distributions. 1-opt tabu search worked best on forests with young age class distributions. Threshold accepting and the raindrop method both performed well on forests with older age class distributions. On average, the raindrop method produced higher quality solutions for most of the problems, and in all but one case where it did not, the solutions generated were not significantly different than the heuristic that located a better solution. The advantage of the raindrop method is that it uses only two parameters and does not require extensive parameterization. The disadvantage is the amount of time it needs to solve problems with area restriction adjacency constraints. We suggest that it may be advantageous to use this heuristic on problems with relatively simple spatial forest planning constraints, and problems that do not involve young initial age class distributions. However, generalization of the performance of the raindrop method to other forest planning problems is problematic, and will require examination by those interested in pursuing this planning methodology. Given that our tests of the raindrop method are limited to a small set of URM and ARM formulations, one should view the combined set of work as additional insight into the potential performance of the method on problems of current interest to the forest planning community.

Introduction: This work investigates the compatibility of integrated care and competition in China and analyses the impact of integrated care on regional care quality (DeptQ) within a competitive framework. Method: The study was built on multivariate correspondence analysis and a two-way fixed-effects model. The data were collected from Xiamen's Big Data Application Open Platform and represent nine specialised departments that regularly performed inter-institutional referrals between 2016 and 2019. Results: First, care quality for referred patients (ReferQ) and the relative scale of referred patients (ReferScale) and competition have an antagonistic but not completely mutually exclusive relationship. Second, ReferQ and competition both have a significant effect on DeptQ, but only when competition is weak can ReferQ and competition act synergistically on DeptQ. When competition is fierce, competition will weaken the impact of ReferQ on DeptQ. Conclusion: Changes in the intensity of integrated care and competition ultimately affect care quality.

A new heuristic method to mitigate infeasibilities when a choice is forced into a solution was developed to solve spatially constrained forest planning problems. One unique aspect of the heuristic is the introduction of unchosen decision choices into a solution regardless of the resulting infeasibilities, which are then mitigated by selecting next-best choices for those spatial units that are affected, but in a radiating manner away from the initial choice. As subsequent changes are made to correct the affected spatial units, more infeasibilities may occur, and these are corrected as well in an outward manner from the initial choice. A single iteration of the model may involve a number of changes to the status of the decision variables, making this an n-opt heuristic process. The second unique aspect of the search process is the periodic reversion of the search to a saved (in computer memory) best solution. Tests have shown that the reversion is needed to ensure better solutions are located. This new heuristic produced solutions to spatial problems that are of equal or comparable in quality to traditional integer programming solutions, and solutions that are better than those produced by two other basic heuristics. Three small hypothetical forest examples illustrate the performance of the heuristic against standard versions of threshold accepting and tabu search. In each of the three examples, the variation in solutions generated from random starting points is smaller with the new heuristic, and the difference in solution values between the new heuristic and the other two heuristics is significant (p

Objective To investigate whether propofol inhibits the expression of miR-141-3p and reduces the molecular mechanism of hypoxia-induced inflammation and apoptosis of pheochromocytoma cell line PC12. Methods PC12 cells were divided into control group, hypoxia group, (5, 10, 20)μmol/L propofol+hypoxia group, anti-miR-con+hypoxia group, anti-miR-141-3p+hypoxia group, miR-con+20 μmol/L propofol+hypoxia group, miR-141-3p+20 μmol/L propofol+hypoxia group. Flow cytometry was used to detect the apoptosis of PC12 cells; Western blot was employed to determine the expression of activated cleaved caspase-3 (cleaved caspase-3) protein, and the kits were implemented to monitor malondialdehyde (MDA) content and superoxide dismutase (SOD) activity; Reactive oxygen species fluorescent probe DCFH-DA method to determine reactive oxygen species (ROS) content; ELISA kits to assay tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 content, RT-qPCR to detect the expression of miR-141-3p. Results Compared with the control group, the apoptosis rate, cleaved caspase-3 protein expression level, MDA, ROS, TNF-α, IL-1β, IL-6 content and miR-141-3p expression of PC12 cells in hypoxia group were all increased, while SOD activity weakened (PPPPConclusions Propofol can alleviate the inflammatory response, oxidative stress and apoptosis of PC12 cells induced by hypoxia by inhibiting the expression of miR-141-3p.

Objective To investigate the expression and clinical significance of S100A14 and LOXL2 in papillary thyroid carcinoma tissues. Methods Paraffin blocks from 90 cases of thyroid lesion were collected to make tissue microarray. The expression of S100A14 and LOXL2 in 30 cases of nodular goiter (NG), 30 cases of classic papillary thyroid carcinoma (CPTC) and 30 cases of high invasion papillary thyroid carcinoma were detected by immunohistochemistry. The correlation of S100A14 and LOXL2 expression with the clinicopathological characteristics of papillary thyroid carcinoma patients was investigated. Results S100A4 and LOXL2 were highly expressed in papillary thyroid carcinoma. There was a gradually increasing trend from the expression in NG group, CPTC group to high invasive group. The positive rate of S100A14 in papillary thyroid carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.05). There was significant difference of S100A14 and LOXL2 expression between CPTC group and high invasion group (P < 0.05). S100A14 expression was positively correlated with LOXL2 expression (r=0.332). Conclusion The high expression of S100A14 and LOXL2 may be related to the malignant biological behavior and invasiveness of papillary thyroid carcinoma, and S100A14 may promote lymph node metastasis.

The existing FFT-WT algorithm and FFT-BP algorithm have advantages only for the detection of certain specific harmonics in photovoltaic systems. In this paper, the FFT-WT algorithm is improved, and a DFFT-WT algorithm is proposed. The FFT-BP algorithm is improved and an improved FFT-BP model is proposed. On the basis of this, the two are combined, the threshold interval is introduced to limit the search scope of the neural network iteration, and a DFFT-WT-BP(Double FFT-WT-BP) detection algorithm is proposed. The simulation results show that the algorithm can detect complex harmonic signals composed of multiple harmonics in the actual photovoltaic network inversion system, and is more accurate and practical.

Based on the comprehensive analyses of many risk factors leading to accidents in immersed tunnel engineering, it is concluded that the risk factors leading to accidents in immersed tunnel engineering are very large and must be paid attention to in all aspects at all stages of the project. This paper classifies and identifies the risk factors in immersed tunnel engineering by investigating and visiting the relevant investigation, design and construction units of immersed tunnel, and then puts forward prevention and control measures to provide theoretical basis for the prevention of risk factors in Immersed Tunnel Engineering in the future and the risk management of the whole project.