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Abstract Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement disorders among humans. Although the specific pathogenesis and associated mechanisms remain unclear, oxidative stress‐induced metabolic imbalance in chondrocytes plays a crucial role in the occurrence and development of osteoarthritis. In this study, a trimanganese tetroxide (Mn3O4) nanozyme with superoxide dismutase (SOD)‐like and catalase (CAT)‐like activities is designed to reduce oxidative stress‐induced damage and its therapeutic effect is investigated. In vitro, Mn3O4 nanozymes are confirmed to reprogram both the imbalance of metabolism in chondrocytes and the uncontrolled inflammatory response stimulated by hydrogen peroxide. In vivo, a cross‐linked chondroitin sulfate (CS) hydrogel is designed as a substrate for Mn3O4 nanozymes to treat osteoarthritis in mouse models. As a result, even in the early stage of OA (4 weeks), the therapeutic effect of the Mn3O4@CS hydrogel is observed in both cartilage metabolism and inflammation. Moreover, the Mn3O4@CS hydrogel maintained its therapeutic effects for at least 7 days, thus revealing a broad scope for future clinical applications. In conclusion, these results suggest that the Mn3O4@CS hydrogel is a potentially effective therapeutic treatment for osteoarthritis, and a novel therapeutic strategy for osteoarthritis based on nanozymes is proposed.

Abstract The pioneering exfoliation of monolayer tungsten diselenide has greatly inspired researchers toward semiconducting applications. WSe2 belongs to a family of transition‐metal dichalcogenides. Similar to graphene, WSe2 and analogous dichalcogenides have layered structures with weak van der Waals interactions between two adjacent layers. First, the readers are presented with the fundamentals of WSe2, such as types, morphologies, and properties. Here, we report the characterization principles and practices such as microscopy, spectroscopy, and diffraction. Second, the methods for obtaining high‐quality WSe2, such as exfoliation, hydrothermal and chemical vapor deposition, are briefly listed. With advantages of light weight, flexibility, and high quantum efficiency, 2D materials may have a niche in optoelectronics as building blocks in p‐n junctions. Therefore, we introduce a state‐of‐the‐art demonstration of heterostructure devices employing the p‐type WSe2 semiconductor. The device architectures include field‐effect transistors, photodetectors, gas sensors, and photovoltaic solar cells. Due to its unique electronic, optical, and energy band properties, WSe2 has been increasingly investigated due to the conductivity of the p‐type charge carrier upon palladium contact. Eventually, the dynamic research on WSe2 and van der Waals heterostructures is summarized to arouse the passion of the 2D research community.

Aftershock fragility is usually calculated conditioned on a range of potential post-mainshock damage states. The post-mainshock damage can be identified using damage indices, the latter being frequently associated with displacement-based parameters such as the maximum drift ratio or the residual displacement. However, when the reliable simulation of a structural system in a specific post-mainshock damage state is the objective of a numerical study, using such damage indicators may not assure the structure experiencing a homogeneous level of damage due to different mainshocks characteristics, which induce the aftershock fragility results unreliable. Along these lines, the current study presents a damage evaluation methodology mainly used for aftershock fragility assessment. It aims to reduce the variation of damage levels derived by using different mainshock seismic motions. The methodology presented herein includes: (i) the introduction of a damage index defined by comparing the monotonic pushover curve of the intact and post-earthquake damaged structure; (ii) the description of a finite element (FE)-based scheme that enables to quantify of the proposed damage index; and (iii) a deterioration-related modeling technique that can capture both strength and stiffness degrading performance of structural systems exposed to earthquake-induced excitations. The latter is essential to support the FE-based quantification scheme for the damage index. This methodology evaluation methodology can be primarily used for calculating the aftershock fragility assessment for a multi-span RC continuous girder bridge. The back-to-back incremental dynamic analysis framework uses a larger number of mainshock-aftershock artificial sequences to generate the aftershock fragility curves. The AS fragility results obtained via MBDI are compared with that via maximum drift ratio in terms of the ability to reduce the variation of residual capacities obtained using different mainshocks to induce a specific damage state but collapse by the same aftershock. The comparison shows a more robust relationship of MBDI with the residual capacity. It is found that MBDI, as well as its quantification approach proposed in this study, is a more effective damage predictor than the widely used displacement-based indices for AS fragility assessment.