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La Serpiente y el Arco Iris (1988) de Wes Craven supone un modelo docente atractivo que combina la farmacología y las alteraciones fisiológicas en muchos sistemas funcionales. Basada en un hecho real, este clásico del terror convertido en una película de culto analiza como el método científico es capaz de dar respuestas al mito del muerto viviente, a través del vudú en la población de Haití, por la inhalación de una potente droga en polvo que contiene altas dosis de tetrodotoxina. Este filme simula el estado agudo de catalepsia de los pacientes y las pruebas sometidas para certificar la aparente defunción tras la confirmación del cese irreversible de las funciones cardiorrespiratorias o encefálica, debido a la ausencia de reflejos troncoencefálicos a causa de los efectos a largo plazo que presenta la droga. Además, a pesar de que el paciente no fallece y es enterrado siendo consciente de todo el proceso, el filme permite reflexionar en los estudiantes la alta carga psicológica, tanto del propio paciente como de la población, que profundiza en los estados de terror al suponer que es un esclavo retornado de la muerte sin alma y sin voluntad.

ABSTRACTScientific advances and technological requirements to develop carbon fibre-reinforced polymers (CFRP) with excellent strength-to-weight ratios led to the high consumption of CFRP composites. The mechanical recycling of CFRP is a simpler, more economical, and environmentally responsible solution for effectively recovering this structural material that contains epoxy resin and carbon fibre. CFRP laminates were placed on a Computer Numerical Control (CNC) and milling cutting at 1100, 1800, and 2500 rpm. The recovered CFRP particles were mixed with acrylonitrile butadiene styrene (ABS) using the melt intercalation approach. Recovered CFRP particles increased the molecular mobility and reduced the thermal stability of ABS. The main differences between the ABS and the composites were a more pronounced necking region in the ABS than in the composites and a notable reduction in strain. The strain of the ABS was 27.58%, while in the composites, it was 4.29, 4.02, and 3.51%, depending on the cutting speed. Thus, ductility decreased up to 87% in the composites. This work’s successful CFRP mechanical recycling method provides epoxy powder, individual carbon fibres, and CFRP particles, opening a research field of great economic and environmental relevance in developing new materials.

Abstract The QUANT study represents the most extensive open-access evaluation of commercial air quality sensor systems to date. This comprehensive study assessed 49 systems from 14 manufacturers across three urban sites in the UK over a three-year period. The resulting open-access dataset captures high time-resolution measurements of a variety of gasses (NO, NO2, O3, CO, CO2), particulate matter (PM1, PM2.5, PM10), and key meteorological parameters (humidity, temperature, atmospheric pressure). The quality and scope of the dataset is enhanced by reference monitors’ data and calibrated products from sensor manufacturers across the three sites. This publicly accessible dataset serves as a robust and transparent resource that details the methods used for data collection and procedures to ensure dataset integrity. It provides a valuable tool for a wide range of stakeholders to analyze the performance of air quality sensors in real-world settings. Policymakers can leverage this data to refine sensor deployment guidelines and develop standardized protocols, while manufacturers can utilize it as a benchmark for technological innovation and product certification. Moreover, the dataset has supported the development of a UK code of practice, and the certification of one of the participating companies, underscoring the dataset’s utility and reliability.

Geopolymers are cementitious materials with exceptional mechanical and physical properties, making them suitable for aerospace applications. Considering their excellent performance, the present investigation aims to develop geopolymers with designed physical properties to address some issues in the aerospace industry. In this sense, the influence of the alkaline activator on the final properties was evaluated. For the development of the geopolymers, sodium hydroxide and sodium metasilicate solutions were preparedto obtain the alkaline activator. The synthesis process also consisted of a mixing stage using a mixer to obtain a homogenous paste. After mixing, the curing process consisted of a first thermal treatment at 60 °C for 4 h to evaporate the excess water, avoid excessive contraction, and promote strength at early ages. Subsequently, the geopolymers were left at rest for 28 days until the final properties were achieved. The influence of the solid-to-liquidratio (S/L) on the microstructure of the geopolymers was evaluated. For this purpose, X-ray fluorescence spectrometry, X-ray diffraction, and infrared spectrometry analyses were performed. The results show that the content of the alkaline activator promotes variations inthe presence of different crystalline phases, which is more noticeable as the S/L ratio increases. Likewise, the infrared spectra display peaks at different wavelengths regarding the variations in elemental composition, which are more evident with the changes in the S/L ratio. In addition, physical studies, such as thermal conductivity and resistance to gamma radiation were conducted for different geopolymer compositions. The results indicate that changes in properties are not too sensitive to compositional variations, although slight modifications exist. Finally, these studies are significant as aerospace-focused materials are directly exposed to this kind of phenomena. The designed geopolymers have to be able to resist and maintain their properties through exposure to any energy.

O presente artigo apresenta a universidade enquanto um território contemporâneo e multifacetado, propício para a inserção dos coletivos indígenas como sujeitos acadêmicos. O objetivo é abordar de forma qualitativa o epistemicídio como uma das manifestações de racismo contra os povos originários presentes na educação superior e que impacta no caráter social universitário, reforçando seu papel eurocêntrico e menos plural – “monocromática”. Além da experiência dos autores com a temática, a revisão de literatura é o procedimento utilizado para se alcançar o objetivo pretendido. Brevemente, discute-se sobre a universidade pública brasileira no século XXI e seus desafios em face de grupos excluídos anteriormente do corpus acadêmico, realidade que vem mudando após a conhecida Lei de Cotas (Lei n. 12.711/2012), revista pelo congresso em 2023. O recorte deste artigo exclui as Licenciaturas Específicas e recai sobre os cursos de graduação regulares, bacharelados e demais licenciaturas, acessíveis via sistema de cotas. Verifica-se que atitudes de preconceito, discriminação e racismo, no seio universitário, perante os discentes indígenas, são práticas rotineiras, mas pouco se discute, o epistemicídio como sendo uma dessas atitudes, qual seja, a de desconsiderar as experiências, conhecimentos e contribuições culturais dos estudantes indígenas. O mesmo ocorre reiterada e sutilmente na vivência acadêmica em decorrência da organização curricular, da condução da pesquisa e extensão e da postura docente. Apresenta-se no artigo uma lista de indicativos para o enfrentamento ao epistemicídio e sua superação no território universitário brasileiro

Abstract Spaceflight presents significant challenges to the physiological state of living organisms. This can be due to the microgravity environment experienced during long-term space missions, resulting in alterations in muscle structure and function, such as atrophy. However, a comprehensive understanding of the adaptive mechanisms of biological systems is required to devise potential solutions and therapeutic approaches for adapting to spaceflight conditions. This review examines the current understanding of the challenges posed by spaceflight on physiological changes, alterations in metabolism, dysregulation of pathways and the suitability and advantages of using the model organism Caenorhabditis elegans nematodes to study the effects of spaceflight. Research has shown that changes in the gene and protein composition of nematodes significantly occur across various larval stages and rearing environments, including both microgravity and Earth gravity settings, often mirroring changes observed in astronauts. Additionally, the review explores significant insights into the fundamental metabolic changes associated with muscle atrophy and growth, which could lead to the development of diagnostic biomarkers and innovative techniques to prevent and counteract muscle atrophy. These insights not only advance our understanding of microgravity-induced muscle atrophy but also lay the groundwork for the development of targeted interventions to mitigate its effects in the future.

In times of growing concern about the impacts of air pollution across the globe, lower-cost sensor technology is giving the first steps in helping to enhance our understanding and ability to manage air quality issues, particularly in regions without established monitoring networks. While the benefits of greater spatial coverage and real-time measurements that these systems offer are evident, challenges still need to be addressed regarding sensor reliability and data quality. Given the limitations imposed by intellectual property, commercial implementations are often “black boxes”, which represents an extra challenge as it limits end users' understanding of the data production process. In this paper we present an overview of the QUANT (Quantification of Utility of Atmospheric Network Technologies) study, a comprehensive 3-year assessment across a range of urban environments in the United Kingdom, evaluating 43 sensor devices, including 119 gas sensors and 118 particulate matter (PM) sensors, from multiple companies. QUANT stands out as one of the most comprehensive studies of commercial air quality sensor systems carried out to date, encompassing a wide variety of companies in a single evaluation and including two generations of sensor technologies. Integrated into an extensive dataset open to the public, it was designed to provide a long-term evaluation of the precision, accuracy and stability of commercially available sensor systems. To attain a nuanced understanding of sensor performance, we have complemented commonly used single-value metrics (e.g. coefficient of determination, R2; root mean square error, RMSE; mean absolute error, MAE) with visual tools. These include regression plots, relative expanded uncertainty (REU) plots and target plots, enhancing our analysis beyond traditional metrics. This overview discusses the assessment methodology and key findings showcasing the significance of the study. While more comprehensive analyses are reserved for future detailed publications, the results shown here highlight the significant variation between systems, the incidence of corrections made by manufacturers, the effects of relocation to different environments and the long-term behaviour of the systems. Additionally, the importance of accounting for uncertainties associated with reference instruments in sensor evaluations is emphasised. Practical considerations in the application of these sensors in real-world scenarios are also discussed, and potential solutions to end-user data challenges are presented. Offering key information about the sensor systems' capabilities, the QUANT study will serve as a valuable resource for those seeking to implement commercial solutions as complementary tools to tackle air pollution.

In the face of a pressing global issue-the escalating threat of antibiotic resistance-the development of new antimicrobial agents is urgent. Nanotechnology, with its innovative approach, emerges as a promising solution to enhance the efficacy of these agents and combat the challenge of microbial resistance. Chitosan nanoparticles (CSNPs) stand out in biomedical applications, particularly in the controlled release of antibiotics, with their unique properties such as biocompatibility, stability, biodegradability, non-toxicity, and simple synthesis processes suitable for sensitive molecules. This study synthesized CSNPs using the ionotropic gelation method, with tripolyphosphate (TPP) as the crosslinking agent. Various CS: TPP ratios (6:1, 5:1, 4:1, 3:1, 2:1) were tested, and the resulting nanoparticles were evaluated using dynamic light scattering (DLS). The CS: TPP ratio of 4:1, with an average hydrodynamic diameter (DHP) of (195 ± 10) nm and a zeta potential of (51 ± 1) mV, was identified as the most suitable for further analysis. The characterization of NPs by Transmission Electron Microscope (TEM) and atomic force microscopy (AFM) revealed diameters of (65 ± 14) nm and (102 ± 18) nm, respectively. Notably, CSNPs exhibited significant aggregation during centrifugation and lyophilization, leading to diameter increases of up to 285% as measured by AFM. The antibacterial activity of CSNPs against Staphylococcus aureus and Escherichia coli was assessed using the resazurin assay. It was found that CSNPs not subjected to centrifugation, freezing, and lyophilization retained their antimicrobial activity. In contrast, those that underwent these processes lost their efficacy, likely due to aggregation and destabilization of the system. This study presents a straightforward and effective protocol for encapsulating sensitive active agents and synthesizing chitosan nanoparticles, a potential system with significant implications in the fight against antibiotic resistance.

This research developed a bio-based polymer composite using polylactic acid (PLA) and agro-industrial residues from coffee by-products (without chemical modification and the use of coupling agents or stabilizers). Agro-industrial residues, such as spent coffee ground (SCG) and coffee silver skin (CSS) as filler, were added into the PLA matrix in different percentages by weight, from 0.5 to 10 wt%. The bio-composites were prepared using solvent-cast films and were characterized by various techniques, including FT-IR, TGA, DSC, XRD, SEM and mechanical tests. Bio-composites' formation was verified using FT-IR and SEM; the material showed good interfacial interaction, with percentages between 3 and 5 wt%. XRD and DSC determined the percentage crystallinity in the bio-composites. SEM found that the bio-composites form crystals, showing their limits after mechanical testing. The bio-composites exhibited enhanced thermal and mechanical properties compared to neat PLA.These bio-based composites show great potential for a wide range of applications in the food industry, including disposable and single-use materials, as well as food packaging. Moreover, their use can significantly contribute to the global demand for eco-friendly materials.

El objetivo del presente texto es contribuir a la reflexión sobre la inserción de las artes y la educación artística en las discusiones de gestión pública en el contexto de las transformaciones del siglo XXI en México. Se propone una estrategia multidisciplinaria desde las humanidades y las ciencias políticas, correlacionando temas como democracia, regímenes de bienestar y educación artística desde una perspectiva histórico-documental. Se estima importante revisarlos de manera conjunta, y en esto recae su relevancia académica, con el fin de profundizar en las problemáticas relacionadas con la educación artística y, de esta manera, señalar áreas de oportunidad en el debate público para encaminarse hacia transformaciones deseables de manera justa y humanista; en términos políticos: el reto es exigir una política social redistributiva en el tema de la educación artística-estética. Se parte de la pregunta general ¿qué se necesita para garantizar, en perspectiva actual, el derecho a la educación artística? Para responder a ésta se recurre a fuentes documentales e históricas en México, aunque idealmente se requiere obtener más información respecto a la organización interna de la SEP, lo mismo que comprender cómo se está organizando interinstitucionalmente con otras instancias estatales, pues también ha faltado comprender cómo cada grupo político está interviniendo para legislar en torno al tema de la educación artística, datos que se espera recopilar para futuras investigaciones. Se considera un hallazgo importante, aunque parece mínimo, encontrar claves concretas para exigir la garantía de la puesta en práctica de políticas en el tema.

This article explores how a re-interpretation of the socio-technical, socio-ecological and transition design approaches to transition from the point of view of Niklas Luhmann’s general systems theory of society. The need to understand and promote changes that include a technological and ecological dimension has led to different approaches, such as socio-technical or socio-environmental approaches, to incorporate links with society. While these approaches often include sociological insights, they rarely offer a general understanding of how these are embedded into society. We need a new environmental sociology that helps catalyze change processes with a collectively reorganized society, empowering more radically transformative actions to change the current structures and processes that have led us to where we are today. The article offers a cross-sectional look at the socio-ecological and socio-technical systems literature, specifically for what concerns their understanding of the ‘systems’ in transition and how they can be governed, and re-interpret it from the theoretical lens of the deep sociological knowledge, which refers to the profound understanding of social systems and their dynamics, embedded in Luhmann’s theory of social systems. From here, we suggest the second-order coupling for a sociologically grounded understanding of the interactions that comprise socio-ecological and socio-technical systems, heterogeneous and almost self-organizing assemblies of social, technical, and natural elements and processes. At the same time, third-order couplings are analyzed, focused on governance, relationships between operations, and structures mediated by a deliberate attempt to ensure coherence and coordination against the autonomy and heterogeneity of socio-techno-ecological systems. Therefore, this manuscript offers a deeper conceptual and methodological understanding of socio-techno-ecological couplings and systems in the context of sustainability transformation and gives insights into its governance.

Abstract Background Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental exposures on health are limited by the diversity of exposures included, especially for early life determinants. We used machine learning methods to build early life exposome risk scores for three health outcomes using environmental, molecular, and clinical data. Methods In this study, we analyzed data from 1622 mother-child pairs from the HELIX European birth cohorts, using over 300 environmental, 100 child peripheral, and 18 mother-child clinical markers to compute environmental-clinical risk scores (ECRS) for child behavioral difficulties, metabolic syndrome, and lung function. ECRS were computed using LASSO, Random Forest and XGBoost. XGBoost ECRS were selected to extract local feature contributions using Shapley values and derive feature importance and interactions. Results ECRS captured 13%, 50% and 4% of the variance in mental, cardiometabolic, and respiratory health, respectively. We observed no significant differences in predictive performances between the above-mentioned methods.The most important predictive features were maternal stress, noise, and lifestyle exposures for mental health; proteome (mainly IL1B) and metabolome features for cardiometabolic health; child BMI and urine metabolites for respiratory health. Conclusions Besides their usefulness for epidemiological research, our risk scores show great potential to capture holistic individual level non-hereditary risk associations that can inform practitioners about actionable factors of high-risk children. As in the post-genetic era personalized prevention medicine will focus more and more on modifiable factors, we believe that such integrative approaches will be instrumental in shaping future healthcare paradigms.

La formación ciudadana es un tema de interés ético y político, con notable presencia dentro de las discusiones universitarias, que tienen como fin hacer frente a escenarios asimétricos presentes en el siglo XXI. Partiendo de estas premisas, el artículo fija como objetivo analizar la dimensión ético-política de la formación ciudadana en la educación superior, considerando los siguientes aspectos: Una breve síntesis sobre el significado conceptual de ciudadanía; señalar la dimensión ético-política de la educación superior, lo que incide en la formación del ser humano integral, que incluye la capacitación axiológica, deontológica y el carácter político de la acción participativa dentro de la colectividad; e indicar la relevancia de la formación ciudadana en la educación superior, reconociendo la importancia que tiene para el progreso material de los pueblos. El diseño de la investigación es de tipo cualitativo, aplicando el método hermenéutico-documental. Entre los principales resultados, se distingue que la formación ciudadana impulsa los encuentros comunitarios, fomenta la inclusión, el respeto, activismo político, teniendo en miras la transformación de la sociedad. Se concluye en la urgencia de replantear la dirección de la educación superior, encaminándole hacia la lucha contra contextos sociales adversos, homogeneización del saber, velando por la formación de ciudadanos libres.

Cuba por su condición de isla y los excelentes atractivos turísticos, constituye un potencial importante para el desarrollo de la actividad de cruceros; sin dudas, el impulso de esta actividad provocará un impacto significativo en el desarrollo sostenible de la economía nacional. En tal sentido, el presente artículo muestra los primeros resultados devenidos de una investigación cuyo objetivo principal es perfeccionar la gestión de la calidad y los niveles de satisfacción de los clientes de la Terminal de Cruceros de la Habana. En este estudio se realiza un análisis desde el punto de vista histórico-lógico y a través de métodos participativos, encuestas y entrevistas con los clientes internos y externos relacionados con la actividad de cruceros, se obtienen las limitaciones que afectan esta actividad en la isla. Se concluye que el accionar consciente e intencionado por parte de las diferentes organizaciones involucradas en el crucerismo, harán posible la optimización y satisfacción de los clientes que visitan la isla por esta modalidad, propiciándose sin dudas el perfeccionamiento y posicionamiento de la imagen Cuba como destino turístico seguro, atractivo y con estándares internacionales de calidad. Palabras clave: crucerismo, turismo, gestión de calidad. ABSTRACT Cuba, due to its status as an island and its excellent tourist attractions, constitutes an important potential for the development of cruise activity; without a doubt, the promotion of this activity will cause a significant impact on the sustainable development of the national economy. In this sense, this article shows the first results from a research whose main objective is to improve quality management and customer satisfaction levels at the Havana Cruise Terminal. In this study, an analysis is carried out from a historical-logical point of view and through participatory methods, surveys and interviews with internal and external clients related to the cruise activity, the limitations that affect this activity on the island are obtained. It is concluded that the conscious and intentional actions on the part of the different organizations involved in cruise tourism will make possible the optimization and satisfaction of clients who visit the island through this modality, undoubtedly promoting the improvement and positioning of Cuba's image as a tourist destination safe, attractive and with international quality standards. Keywords: cruise ship, tourism, quality management.

Background: Bisphenol A (BPA; or 4,4′-isopropylidenediphenol) is an endocrine disrupting chemical. It was widely used in a variety of plastic-based manufactured products for several years. The European Food Safety Authority (EFSA) recently reduced the Tolerable Daily Intake (TDI) for BPA by 20,000 times due to concerns about immune-toxicity. Objective: We used human biomonitoring (HBM) data to investigate the general level of BPA exposure from 2007 to 2014 of European women aged 18–73 years (n = 4,226) and its determinants. Methods: Fifteen studies from 12 countries (Austria, Belgium, Denmark, France, Germany, Greece, Israel, Luxembourg, Slovenia, Spain, Sweden, and the United Kingdom) were included in the BPA Study protocol developed within the European Joint Programme HBM4EU. Seventy variables related to the BPA exposure were collected through a rigorous post-harmonization process. Linear mixed regression models were used to investigate the determinants of total urine BPA in the combined population. Results: Total BPA was quantified in 85–100 % of women in 14 out of 15 contributing studies. Only the Austrian PBAT study (Western Europe), which had a limit of quantification 2.5 to 25-fold higher than the other studies (LOQ=2.5 µg/L), found total BPA in less than 5 % of the urine samples analyzed. The geometric mean (GM) of total urine BPA ranged from 0.77 to 2.47 µg/L among the contributing studies. The lowest GM of total BPA was observed in France (Western Europe) from the ELFE subset (GM=0.77 µg/L (0.98 µg/g creatinine), n = 1741), and the highest levels were found in Belgium (Western Europe) and Greece (Southern Europe), from DEMOCOPHES (GM=2.47 µg/L (2.26 µg/g creatinine), n = 129) and HELIX-RHEA (GM=2.47 µg/L (2.44 µg/g creatinine), n = 194) subsets, respectively. One hundred percent of women in 14 out of 15 data collections in this study exceeded the health-based human biomonitoring guidance value for the general population (HBM-GVGenPop) of 0.0115 µg total BPA/L urine derived from the updated EFSA’s BPA TDI. Variables related to the measurement of total urine BPA and those related to the main socio-demographic characteristics (age, height, weight, education, smoking status) were collected in almost all studies, while several variables related to BPA exposure factors were not gathered in most of the original studies (consumption of beverages contained in plastic bottles, consumption of canned food or beverages, consumption of food in contact with plastic packaging, use of plastic film or plastic containers for food, having a plastic floor covering in the house, use of thermal paper…). No clear determinants of total urine BPA concentrations among European women were found. A broader range of data planned for collection in the original questionnaires of the contributing studies would have resulted in a more thorough investigation of the determinants of BPA exposure in European women. Conclusion: This study highlights the urgent need for action to further reduce exposure to BPA to protect the population, as is already the case in the European Union. The study also underscores the importance of pre-harmonizing HBM design and data for producing comparable data and interpretable results at a European-wide level, and to increase HBM uptake by regulatory agencies.

Background: Precision Health aims to revolutionize disease prevention by leveraging information across multiple omic datasets (multi-omics). However, existing methods generally do not consider personalized environmental risk factors (e.g., environmental pollutants). Objective: To develop and apply a precision health framework which combines multiomic integration (including early, intermediate, and late integration, representing sequential stages at which omics layers are combined for modeling) with mediation approaches (including high-dimensional mediation to identify biomarkers, mediation with latent factors to identify pathways, and integrated/quasi-mediation to identify high-risk subpopulations) to identify novel biomarkers of prenatal mercury induced metabolic dysfunction-associated fatty liver disease (MAFLD), elucidate molecular pathways linking prenatal mercury with MAFLD in children, and identify high-risk children based on integrated exposure and multiomics data. Methods: This prospective cohort study used data from 420 mother–child pairs from the Human Early Life Exposome (HELIX) project. Mercury concentrations were determined in maternal or cord blood from pregnancy. Cytokeratin 18 (CK-18; a MAFLD biomarker) and five omics layers (DNA Methylation, gene transcription, microRNA, proteins, and metabolites) were measured in blood in childhood (age 6–10 years). Results: Each standard deviation increase in prenatal mercury was associated with a 0.11 [95% confidence interval: 0.02–0.21] standard deviation increase in CK-18. High dimensional mediation analysis identified 10 biomarkers linking prenatal mercury and CK-18, including six CpG sites and four transcripts. Mediation with latent factors identified molecular pathways linking mercury and MAFLD, including altered cytokine signaling and hepatic stellate cell activation. Integrated/quasi-mediation identified high risk subgroups of children based on unique combinations of exposure levels, omics profiles (driven by epigenetic markers), and MAFLD. Conclusions: Prenatal mercury exposure is associated with elevated liver enzymes in childhood, likely through alterations in DNA methylation and gene expression. Our analytic framework can be applied across many different fields and serve as a resource to help guide future precision health investigations.

The integration of technology in higher education has transformed teaching, turning students into active participants in their learning. Faced with the limitations of conventional methods, the integration of technological and creative methods adapted to current demands is being sought.Proficiency in word processing and spreadsheets is crucial in university education, especially in social sciences and law, where the lack of specialized technical training affects academic performance. This study analyzes the impact of incorporating serious games with technological tools and active teaching methods on students' motivation, engagement and academic performance.

Com a Constituição Federal de 1988 que rompe com a política de integração e garante o status de cidadania, o direito à diferença e à autonomia aos povos indígenas, temos presenciado um crescimento significativo dessas populações circulando nos espaços das universidades. Neste sentido, tendo como referência as experiências vividas com indígenas em cursos de pós-graduação (mestrado e doutorado) no Mato Grosso do Sul e alguns anos de pesquisa com a temática, o artigo busca refletir a presença dos indígenas nos cursos de Graduação e Pós-Graduação e suas contribuições para a construção de uma pedagogia intercultural. Amparado em estudos que estão marcados pelo pensamento de intelectuais que se orientam pela cosmovisão de populações tradicionais, o estudo apresenta que a convivência presencial com a diferença tem sido enriquecedora, pois tem possibilitado o compromisso político-epistêmico e pedagógico de encontrar as brechas e as fissuras para estabelecer uma relação de mão dupla que possibilite a todos os envolvidos tensões e conflitos, o desaprender e reaprender com outras percepções e questionamentos críticos, além de reelaborar a relação com a diferença, com as marcas da colonização e da colonialidade que insistem em povoar nossos conceitos e preconceitos, bem como em fortalecer os estereótipos historicamente produzidos com relação aos povos indígenas.

The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle. However, the precise molecular composition of these mechanisms remains unclear. Our data show that inorganic polyphosphate (polyP), a polymer well-conserved throughout evolution, is a component of these mechanisms. In mammals, mitochondria exhibit a significant abundance of polyP, and both our research and that of others have already highlighted its potent regulatory effect on bioenergetics. Given the intimate connection between energy metabolism and protein homeostasis, the involvement of polyP in proteostasis has also been demonstrated in several organisms. For example, polyP is a bacterial primordial chaperone, and its role in amyloidogenesis has already been established. Here, using mammalian models, our study reveals that the depletion of mitochondrial polyP leads to increased protein aggregation within the organelle, following stress exposure. Furthermore, mitochondrial polyP is able to bind to proteins, and these proteins differ under control and stress conditions. The depletion of mitochondrial polyP significantly affects the proteome under both control and stress conditions, while also exerting regulatory control over gene expression. Our findings suggest that mitochondrial polyP is a previously unrecognized, and potent component of mitochondrial proteostasis.

IntroductionLevilactobacillus brevis CRL 2013, a plant-derived lactic acid bacterium (LAB) with immunomodulatory properties, has emerged as an efficient producer of γ-aminobutyric acid (GABA). Notably, not all LAB possess the ability to produce GABA, highlighting the importance of specific genetic and environmental conditions for GABA synthesis. This study aimed to elucidate the intriguing GABA-producing machinery of L. brevis CRL 2013 and support its potential for safe application through comprehensive genome analysis.MethodsA comprehensive genome analysis of L. brevis CRL 2013 was performed to identify the presence of antibiotic resistance genes, virulence markers, and genes associated with the glutamate decarboxylase system, which is essential for GABA biosynthesis. Then, an optimized chemically defined culture medium (CDM) was supplemented with monosodium glutamate (MSG) and yeast extract (YE) to analyze their influence on GABA production. Proteomic and transcriptional analyses were conducted to assess changes in protein and gene expression related to GABA production.ResultsThe absence of antibiotic resistance genes and virulence markers in the genome of L. brevis CRL 2013 supports its safety for potential probiotic applications. Genes encoding the glutamate decarboxylase system, including two gad genes (gadA and gadB) and the glutamate antiporter gene (gadC), were identified. The gadB gene is located adjacent to gadC, while gadA resides separately on the chromosome. The transcriptional regulator gadR was found upstream of gadC, with transcriptional analyses demonstrating cotranscription of gadR with gadC. Although MSG supplementation alone did not activate GABA synthesis, the addition of YE significantly enhanced GABA production in the optimized CDM containing glutamate. Proteomic analysis revealed minimal differences between MSG-supplemented and non-supplemented CDM cultures, whereas YE supplementation resulted in significant proteomic changes, including upregulation of GadB. Transcriptional analysis confirmed increased expression of gadB and gadR upon YE supplementation, supporting its role in activating GABA production.ConclusionThese findings provide valuable insights into the influence of nutrient composition on GABA production. Furthermore, they unveil the potential of L. brevis CRL 2013 as a safe, nonpathogenic strain with valuable biotechnological traits which can be further leveraged for its probiotic potential in the food industry.

Unmanned aerial vehicles (UAVs) have seen remarkable improvements in their flight capabilities and computational power. Their applications span various domains, such as agriculture, military, and communications. To improve communication quality and coverage in UAV-enabled systems, understanding effective placement techniques is crucial. While research has explored optimal UAV placement in two dimensions, there is a need for a comprehensive three-dimensional (3D) analysis, particularly for resource optimization. This article presents a systematic mapping study on 3D placement in UAV-enabled communication systems, incorporating a threat analysis for the reliability of the results. It provides valuable insights for future research on 3D placement optimization techniques, specifically examining optimization objectives, model system features, problem types, and solution strategies. Our research reveals, on one hand, an emphasis on optimizing data rate throughput, power transmission, and ground coverage, and a predominant use of large-scale fading in the air-to-ground channel model; on the other hand, heuristic algorithms prevail as the solution strategy. Moreover, we identify gaps in achieving critical objectives such as the probability of outage, deployment costs, quality of experience, and spectrum optimization. This highlights the need for further exploration in the formulation aspects of the system, which includes small-scale fading, access techniques, and interference management.

Abstract Long non-coding RNAs (lncRNAs) comprise the most representative transcriptional units of the mammalian genome. They are associated with organ development linked with the emergence of cardiovascular diseases. We used bioinformatic approaches, machine learning algorithms, systems biology analyses, and statistical techniques to define co-expression modules linked to heart development and cardiovascular diseases. We also uncovered differentially expressed transcripts in subpopulations of cardiomyocytes. Finally, from this work, we were able to identify eight cardiac cell-types; several new coding, lncRNA, and pcRNA markers; two cardiomyocyte subpopulations at four different time points (ventricle E9.5, left ventricle E11.5, right ventricle E14.5 and left atrium P0) that harbored co-expressed gene modules enriched in mitochondrial, heart development and cardiovascular diseases. Our results evidence the role of particular lncRNAs in heart development and highlight the usage of co-expression modular approaches in the cell-type functional definition.

Fungemia remains a major threat in intensive care units (ICUs), with high mortality rates despite advances in diagnostics and treatment. Colonisation by yeasts is an independent risk factor for fungemia; however, its predictive utility requires further research. In this 8-year study, we analysed 38,017 samples from 3206 patients and 171 fungemia episodes as part of a weekly fungal surveillance programme. We evaluated species-specific colonisation patterns, the predictive value of the Colonisation Index (CI) and Corrected Colonisation Index (CCI), and candidemia risks associated with different yeast species and anatomical site colonisation. Our results showed that C. auris, N. glabratus, and C. parapsilosis colonisation increased with longer hospital stays (0.8% to 11.55%, 8.13% to 16.8%, and 1.93% to 5.14%, respectively). The CI and CCI had low discriminatory power (AUROC 67% and 66%). Colonisation by any yeast genera demonstrated high sensitivity (98.32%) and negative predictive value (NPV) (95.90%) but low specificity and positive predictive value (PPV) (23.90% and 6.64%). Tracheal and urine cultures had the highest PPV (15.64% and 12.91%), while inguinal cultures had the highest NPV (98.60%). C. auris (12.32%) and C. parapsilosis (5.5%) were associated with a higher fungemia risk (log-rank < 0.001). These findings support the use of weekly surveillance to better stratify the fungemia risk and optimise antifungal use in ICUs.

IntroductionReliability is a property of tests scores that varies from sample to sample. One way of generalizing reliability of a test is to perform a meta-analysis on some reliability estimator. In 2011, a reliability generalization meta-analysis on the Maslach Burnout Inventory (MBI) was conducted, concluding that average alpha values for the MBI dimensions ranged from 0.71 to 0.88. In the present study, we aimed to update the average reliability values of the MBI by conducting a literature search from 2010 until now and comparing to statistical procedures of meta-analysis: the Univariate approach, that were used in the previous study, and a novel meta-analytic approach based on structural equation modeling.MethodAn estimation of average reliability was done based on 69 independent primary reliability coefficients for the Univariate approach. The average reliability was based on 9 independent studies in the case of the Meta-analytic Structural Equation Modeling (MASEM) approach. Given that MASEM has the additional capability of testing the internal structure of a test, we also fitted several models.ResultsThe data was well-suited to the bifactor model, revealing the dominance of the general factor over the domain-specific ones. Acceptable overall alpha and omega coefficients were achieved for the two of the MBI dimensions, having depersonalization reliability estimates below recommendations.DiscussionIn general, the MBI can be viewed as a highly interconnected three-factor scale, being its appropriate for research purposes.

The conquest of the terrestrial environment required numerous adaptations, although aerial respiration was what allowed animals to become completely independent of aquatic environments. Here, we analyze the specialized organs for air respiration, describing lungs, tracheas and some modifications of these organs that have occurred in certain gastropods and arthropods. These organs have appeared independently on numerous occasions, even in closely related taxa, and have experienced frequent regressions. In some cases, as in the case of the snail's palaeal cavity, the organs evolved from homologous structures, but independently in different lineages, with specific areas of the nervous system always being responsible for their control. Although the neurons that perform these tasks are ancient and may have a common evolutionary history, homologous visceral control structures do not seem to exist in vertebrates, nor among invertebrate phyla. This situation is clearly a consequence of the fact that respiration has evolved independently on numerous occasions, even within the same phylum, so that specific organs may be lost, or equivalent organs may arise independently and secondarily. However, as they arise from common ancestral structures, there could be cases of deep homology.

Actinotignum schaalii affects elderly people and is associated with individuals with urological-related predispositions, but can be found in a variety of locations, such as cutaneous, intraabdominal, genitourinary and surgical infections. Disseminated infections occur less frequently and are by and large related to urinary tract colonisation.This pathogen is often neglected due to growth requirements, especially in urinary tract infections. We present 107 Actinotignum schaalii isolated from genitourinary samples (80.4%), from skin and soft tissue infections (13.1%), from bone and deep tissue infection (4.7%) and from blood cultures (1.9%). The automated system Alfred 60/AST was paramount for the isolation of 77.6% of the UTI.All the isolates tested were susceptible to penicillin, ampicillin, linezolid, vancomycin, teicoplanin, rifampicin and tetracycline.In conclusion, we present a large series of Actinotignum schaalii infections. This pathogen is hard to isolate, and is resistant to commonly used empirical antimicrobials.

Milk markers have the potential to aid in the detection of cow disease in early lactation if the automation of milk analysis becomes commonplace. Characterising temporal profiles of milk markers in dairy cows will improve the understanding of basal concentrations in clinically healthy cows. The objective of this observational study was to characterise the variation and temporal profiles of colostrum and milk haptoglobin (Hp) and substance P concentrations within 21 days postcalving in clinically healthy multiparous Holstein dairy cows. Ninety Holstein dairy cows from a commercial dairy herd were included. Milk samples were collected on the day of calving (day 0), and on days 1 to 4, 7, 14, and 21 postcalving and concentrations of Hp and substance P in colostrum (days 0 to 3) and milk (days 4, 7, 14, and 21) were determined using Enzyme Linked Immunosorbent assay. Haptoglobin and substance P concentrations were, on average (raw means ± SD), 0.40 ± 0.26 µg/ml and 56.2 ± 38.7 pg/ml in colostrum, respectively, and 0.23 ± 0.23 µg/ml and 37.1 ± 27.8 pg/ml in milk, respectively. Haptoglobin and substance P were elevated and greatest 1 day postcalving (least squares mean ± SE of the mean; 0.53 ± 0.05 µg/ml and 46.5 ± 3.64 pg/ml, respectively) and substance P varied widely within 21 days postcalving. The presence of substance P in dairy cow colostrum was not documented previously. Elevated concentrations of Hp and substance P immediately postcalving may be due to physiological roles these inflammatory markers have in the dairy cow or neonate or may simply represent an accumulation in colostrum before the first milk is removed.

El turismo constituye una importante actividad socioeconómica para Cuba. Mediante la modalidad de ecoturismo se ha extendido por la nación como una forma de apreciación de los recursos naturales que ostenta nuestra nación, como es el caso de Delta del Cauto, uno de los humedales de mayor relevancia del Caribe insular. Con categoría de manejo Refugio de Fauna, es una de las áreas protegidas en la provincia de Granma, además de que es uno de los seis Sitios Ramsar que conserva nuestro país. El presente artículo tuvo como objetivos evaluar las principales potencialidades del Refugio de Fauna Delta del Cauto para el impulso del ecoturismo, analizar las labores y los programas de conservación que se desarrollan en el área de estudio y determinar los principales valores naturales y actividades que pueden explotarse con el empleo de métodos teóricos tales como: el analítico-sintético y el cartográfico mediante el empleo de los Sistemas de Información Geográfica, además de la observación in situ y la revisión bibliográfica. La propuesta que se ofrece va encaminada a convertir el Delta del Cauto en un sitio de gran interés para nacionales y extranjeros a partir del estudio de los significativos valores naturales y socioculturales que posee, el diseño de un sendero acuático y la definición de actividades de ocio a implementar, lo cual permitió determinar como principal conclusión de la investigación, que esta área protegida posee enormes potencialidades para el fomento del ecoturismo.

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and highly heritable neurodevelopmental disorder of major societal concern. Diagnosis can be challenging and there are large knowledge gaps regarding its etiology, though studies suggest an interplay of genetic and environmental factors involving epigenetic mechanisms. MicroRNAs (miRNAs) show promise as biomarkers of human pathology and novel therapies, and here we aimed to identify blood miRNAs associated with traits of ADHD as possible biomarker candidates and further explore their biological relevance. Methods Our study population consisted of 1126 children (aged 5–12 years, 46% female) from the Human Early Life Exposome study, a study spanning six ongoing population-based European birth cohorts. Expression profiles of miRNAs in whole blood samples were quantified by microarray and tested for association with ADHD-related measures of behavior and neuropsychological functions from questionnaires (Conner’s Rating Scale and Child Behavior Checklist) and computer-based tests (the N-back task and Attention Network Test). Results We identified 29 miRNAs significantly associated (false discovery rate

Carbon fiber reinforced polymer (CFRP) composites have very high specific properties, which is why they are used in the aerospace, wind power, and sports sectors. However, the high consumption of CFRP compounds leads to a high volume of waste, and it is necessary to formulate mechanical recycling strategies for these materials at the end of their useful life. The recycling differences between cutting-end mills and high-energy ball milling (HEBM) were evaluated. HEBM recycling allowed us to obtain small recycled particles, but separating their components, carbon fiber, epoxy resin, and CFRP particles, was impossible. In the case of mill recycling, these were obtained directly from cutting a CFRP composite laminate. The recycled materials resulted in a combination of long fibers and micrometric particles—a sieving step allowed for more homogeneous residues. Although long, individual carbon fibers can pass through the sieve. Ultrasonication did not significantly affect HEBM recyclates because of the high energy they are subjected to during the grinding process, but it was influential on end mill recyclates. The ultrasonication amplitude notably impacted the separation of the epoxy resin from the carbon fiber. The end mill and HEBM waste production process promote the presence of trapped air and electrostatics, which allows recyclates to float in water and be hydrophobic.

Optimization of the energy consumption of a Dorna 1 commercial robot was carried out by replacing the original materials of the links (aluminum) with a lighter and more resistant material (carbon fiber) with the aim of lowering the operating costs of the robot. For this reason, a reduction in the total mass of the robot of 11.08% was achieved by replacing the original materials. In addition, simulations were carried out using finite element analysis to verify that the mechanical resistance of the optimized parts was adequate according to the level of demand that occurs during the operation of the robot. Subsequently, a comparison of the energy consumption of the original robot and the robot with the optimized parts was carried out using the Internet-of-Things device. The tests were carried out at three different speeds—1000, 3000, and 9000 deg/min—for 15 min by executing a pre-established routine starting from home. The results showed that at all test speeds, there were energy savings, but the greatest energy savings occurred at the speed of 3000 degrees/min in the range of 3.66%. With this result, it has been shown that the integration of light materials in robots can achieve energy savings.

HUB3D represents a cutting-edge solution for managing and operating a 3D printer farm through the integration of advanced hardware and software. It features intuitive, responsive interfaces that support seamless interaction across various devices. Leveraging cloud services ensures the system’s stability, security, and scalability, enabling users from diverse locations to effortlessly upload and manage their 3D printing projects. The hardware component includes a purpose-built rack capable of housing up to four 3D printers, each synchronized and managed by a manipulator arm controlled via Raspberry Pi technology. This setup facilitates continuous operation and high automation, optimizing production efficiency and reducing downtime significantly. This integrated approach positions HUB3D at the forefront of additive manufacturing management. By combining robust hardware capabilities with sophisticated software functionalities and cloud integration, the system offers unparalleled advantages. It supports continuous manufacturing processes, enhances workflow efficiency, and enables remote monitoring and management of printing operations. Overall, HUB3D’s innovative design and comprehensive features cater to both individual users and businesses seeking to streamline 3D printing workflows. With scalability, automation, and remote accessibility at its core, HUB3D represents a pivotal advancement in modern manufacturing technology, promising increased productivity and operational flexibility in the realm of additive manufacturing.

In practice, most industrial robot manipulators use PID (Proportional + Integral + Derivative) controllers, thanks to their simplicity and adequate performance under certain conditions. Normally, this type of controller has a good performance in tasks where the robot moves freely, performing movements without contact with its environment. However, complications arise in applications such as the AFP (Automated Fiber Placement) process, where a high degree of precision and repeatability is required in the control of parameters such as position and compression force for the production of composite parts. The control of these parameters is a major challenge in terms of quality and productivity of the final product, mainly due to the complex geometry of the part and the type of tooling with which the AFP system is equipped. In the last decades, several control system approaches have been proposed in the literature, such as classical, adaptive or sliding mode control theory based methodologies. Nevertheless, such strategies present difficulties to change their dynamics since their design consider only some set of disturbances. This article presents a novel intelligent type control algorithm based on back-propagation neural networks (BP-NNs) combined with classical PID/PI control schemes for force/position control in manipulator robots. The PID/PI controllers are responsible for the main control action, while the BP-NNs contributes with its ability to estimate and compensate online the dynamic variations of the AFP process. It is proven that the proposed control achieves both, stability in the Lyapunov sense for the desired interaction force between the end-effector and the environment, and position trajectory tracking for the robot tip in Cartesian space. The performance and efficiency of the proposed control is evaluated by numerical simulations in MATLAB-Simulink environment, obtaining as results that the errors for the desired force and the tracking of complex trajectories are reduced to a range below 5% in root mean square error (RMSE).

Current operations involving Dismantling and Decommissioning (D&D) in nuclear and other harsh environments rely on manual inspection and assessment of the sites, exposing human operators to potentially dangerous situations. This work presents a reconfigurable Autonomous Mobile Robot (AMR) able to mount a wide range of nuclear sensors for flexible and modular inspection tasks in these operations. This AMR is part of the CLEANDEM solution, which uses Unmanned Ground Vehicles (UGVs), nuclear sensors, and a Digital Twin to facilitate a tool for improving D&D operations in nuclear sites. Both the AMR used as a UGV and the system have been successfully tested in real nuclear sites, showing that these tools can greatly aid in operations management and hazard reduction.

Industrial automation in the manufacturing environment has revolutionized production and manufacturing in many industries, generating significant improvements in efficiency, quality, and process effectiveness. However, it has also posed challenges related to feedback in manufacturing environment monitoring systems, and increasing the effectiveness, productivity, and quality in industrial production. Feedback systems in the manufacturing environment are fundamental to industrial automation, which is why an application has been developed for the detection of elements in a printed circuit board manufacturing cell. The solution presented in this article proposes implementing a continuous feedback system with the ability to provide real-time information to identify the location of elements in a manufacturing cell and potentially detect anomalies, with the goal of improving the manufacturing process appropriately.

The pandemic meant a change in academic approach. This had an impact on the mental health of students, leading to, among other problems, depressive disorders. The aim of this study was to find out the prevalence and factors that favoured the development of depression in nursing students during the COVID-19 pandemic. A systematic review with meta-analysis of prevalence was conducted in October 2023, using Pubmed, CINAHL and Scopus as the data sources used for the search. This review followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Search equation was: "(undergraduate nurses OR nursing students) AND depression AND (COVID-19 OR Sars-CoV-2)". The final set of articles was N = 12. Quantitative primary studies using anonymous scales and surveys to assess the prevalence of depression in nursing students in the last 3 years were included. Studies show a high prevalence of depression among young university students with figures above 50%. The total sample of students in the meta-analysis was n = 4,479 with a prevalence value of 32% (CI95% 22%-42%). Affected students are characterised by young, female students. Concerns included generalised academic uncertainty, social isolation, work overload, fear of contagion and concern about teaching delivery. Coping mechanisms were generally resilience, spiritual support, laughter therapy, seeking information about COVID-19 and eating food. In conclusion, students, especially female students, are at high risk of depression due to social isolation. In addition, coping techniques were inadequate and future strategies to prevent this situation should be considered.

Las interacciones sociales facilitan el intercambio de información constante, dando como resultado nuevos paradigmas en las sociedades interculturales. La presente investigación se planteó como objetivo principal establecer las consecuencias de la interacción social en la comunicación intercultural de la comuna Chigüilpe, en el cantón Santo Domingo, analizando el impacto de la convivencia y las características de las personas que interactúan en la comuna. La búsqueda de la información se desarrolló con el nivel de asociación de variables, que permitió constituir predicciones a través de la intervención de las relaciones entre los contenidos, midiéndose el grado de relación y a partir de ello, determinar tendencias o modelos de comportamiento mayoritario, de modo que la obtención de resultado a través del cuestionario de investigación, contraste la información de la guía de observación y la entrevista semiestructurada. Los resultados de la investigación obtenidos de los nativos Tsáchilas, comprobaron que las interacciones sociales generan ingresos económicos favorables, sin embargo, en el proceso se pierden sus costumbres y tradiciones, siendo la consecuencia más notable, en la población limitada que existen la actualidad, ya que tanto jóvenes como adultos, prefieren mejorar sus condiciones de vida abandonando el territorio originario de nacimiento y con ellos sus costumbres y tradiciones.

Fraud detection through auditors’ manual review of accounting and financial records has traditionally relied on human experience and intuition. However, replicating this task using technological tools has represented a challenge for information security researchers. Natural language processing techniques, such as topic modeling, have been explored to extract information and categorize large sets of documents. Topic modeling, such as latent Dirichlet allocation (LDA) or non-negative matrix factorization (NMF), has recently gained popularity for discovering thematic structures in text collections. However, unsupervised topic modeling may not always produce the best results for specific tasks, such as fraud detection. Therefore, in the present work, we propose to use semi-supervised topic modeling, which allows the incorporation of specific knowledge of the study domain through the use of keywords to learn latent topics related to fraud. By leveraging relevant keywords, our proposed approach aims to identify patterns related to the vertices of the fraud triangle theory, providing more consistent and interpretable results for fraud detection. The model’s performance was evaluated by training with several datasets and testing it with another one that did not intervene in its training. The results showed efficient performance averages with a 7% increase in performance compared to a previous job. Overall, the study emphasizes the importance of deepening the analysis of fraud behaviors and proposing strategies to identify them proactively.

Introduction: Inorganic polyphosphate (polyP) is an ancient polymer which is extremely well-conserved throughout evolution, and found in every studied organism. PolyP is composed of orthophosphates linked together by high-energy bonds, similar to those found in ATP. The metabolism and the functions of polyP in prokaryotes and simple eukaryotes are well understood. However, little is known about its physiological roles in mammalian cells, mostly due to its unknown metabolism and lack of systematic methods and effective models for the study of polyP in these organisms.Methods: Here, we present a comprehensive set of genetically modified cellular models to study mammalian polyP. Specifically, we focus our studies on mitochondrial polyP, as previous studies have shown the potent regulatory role of mammalian polyP in the organelle, including bioenergetics, via mechanisms that are not yet fully understood.Results: Using SH-SY5Y cells, our results show that the enzymatic depletion of mitochondrial polyP affects the expression of genes involved in the maintenance of mitochondrial physiology, as well as the structure of the organelle. Furthermore, this depletion has deleterious effects on mitochondrial respiration, an effect that is dependent on the length of polyP. Our results also show that the depletion of mammalian polyP in other subcellular locations induces significant changes in gene expression and bioenergetics; as well as that SH-SY5Y cells are not viable when the amount and/or the length of polyP are increased in mitochondria.Discussion: Our findings expand on the crucial role of polyP in mammalian mitochondrial physiology and place our cell lines as a valid model to increase our knowledge of both mammalian polyP and mitochondrial physiology.

Outcome-wide analysis can offer several benefits, including increased power to detect weak signals and the ability to identify exposures with multiple effects on health, which may be good targets for preventive measures. Recently, advanced statistical multivariate techniques for outcome-wide analysis have been developed, but they have been rarely applied to exposome analysis. In this work, we provide an overview of a selection of methods that are well-suited for outcome-wide exposome analysis and are implemented in the R statistical software. Our work brings together six different methods presenting innovative solutions for typical problems arising from outcome-wide approaches in the context of the exposome, including dependencies among outcomes, high dimensionality, mixed-type outcomes, missing data records, and confounding effects. The identified methods can be grouped into four main categories: regularized multivariate regression techniques, multi-task learning approaches, dimensionality reduction approaches, and bayesian extensions of the multivariate regression framework. Here, we compare each technique presenting its main rationale, strengths, and limitations, and provide codes and guidelines for their application to exposome data. Additionally, we apply all selected methods to a real exposome dataset from the Human Early-Life Exposome (HELIX) project, demonstrating their suitability for exposome research. Although the choice of the best method will always depend on the challenges to be faced in each application, for an exposome-like analysis we find dimensionality reduction and bayesian methods such as reduced rank regression (RRR) or multivariate bayesian shrinkage priors (MBSP) particularly useful, given their ability to deal with critical issues such as collinearity, high-dimensionality, missing data or quantification of uncertainty.

The Analytic Hierarchy Process (AHP) is a multi-criteria decision support method and is widely applied in many areas. The original AHP method proposed by Thomas L. Saaty in the 1970s requires (n²-n)/2 comparisons. The number of required comparisons can make using this method challenging for maintaining consistent judgments in problems involving many criteria and/or alternatives. Furthermore, the available software is platform-dependent and generally does not support group decision-making. In this paper, we present software for AHP that demands n-1 comparisons. Additionally, the software supports group decision-making using individual aggregation of priorities with arithmetic and geometric means. The system is available at http://ahpweb.net/ and is accessible from any internet-connected device. It currently has more than 100 users and dozens of decision problems in various areas. • The original AHP formulation requires (n²-n)/2 comparisons per cluster which makes it difficult to make consistent judgments. • AHP avaliable software does not enable group decision making. • The proposed system AHP-WEB fills these gaps. The method demands n-1 comparisons per cluster without any inconsistency and allows group decision making on a web system.

Abstract Background Obesity and neurodevelopmental delay are complex traits that often co-occur and differ between boys and girls. Prenatal exposures are believed to influence children’s obesity, but it is unknown whether exposures of pregnant mothers can confer a different risk of obesity between sexes, and whether they can affect neurodevelopment. Methods We analyzed data from 1044 children from the HELIX project, comprising 93 exposures during pregnancy, and clinical, neuropsychological, and methylation data during childhood (5–11 years). Using exposome-wide interaction analyses, we identified prenatal exposures with the highest sexual dimorphism in obesity risk, which were used to create a multiexposure profile. We applied causal random forest to classify individuals into two environments: E1 and E0. E1 consists of a combination of exposure levels where girls have significantly less risk of obesity than boys, as compared to E0, which consists of the remaining combination of exposure levels. We investigated whether the association between sex and neurodevelopmental delay also differed between E0 and E1. We used methylation data to perform an epigenome-wide association study between the environments to see the effect of belonging to E1 or E0 at the molecular level. Results We observed that E1 was defined by the combination of low dairy consumption, non-smokers’ cotinine levels in blood, low facility richness, and the presence of green spaces during pregnancy (ORinteraction = 0.070, P = 2.59 × 10−5). E1 was also associated with a lower risk of neurodevelopmental delay in girls, based on neuropsychological tests of non-verbal intelligence (ORinteraction = 0.42, P = 0.047) and working memory (ORinteraction = 0.31, P = 0.02). In line with this, several neurodevelopmental functions were enriched in significant differentially methylated probes between E1 and E0. Conclusions The risk of obesity can be different for boys and girls in certain prenatal environments. We identified an environment combining four exposure levels that protect girls from obesity and neurodevelopment delay. The combination of single exposures into multiexposure profiles using causal inference can help determine populations at risk.

Nikosia es una radio y una serie de dispositivos comunicacionales en red realizados por personas en tratamiento psiquiátrico. Es una de las primeras emisoras en el territorio español en emitir desde la llamada locura. A partir de un breve análisis de su funcionamiento y articulación como estructura de comunicación y cuidados, la propuesta de este artículo es reflexionar sobre el papel de los medios como altavoces para la palabra de aquellos colectivos históricamente silenciados, y como contextos de posibilidad en las luchas por el cambio y la justicia social en el ámbito de la salud mental. El texto propone entender a Nikosia como un espacio comunicacional de cuestionamiento de la hegemonía psiquiátrica y una instancia de producción de nuevas significaciones en relación con los malestares emocionales y la salud psíquica de las poblaciones. Como un territorio/experiencia que promueve la recuperación del diálogo entre sociedad y locura; un espacio político y comunicacional que habilita en sus participantes la posibilidad de dejar de ser objetos de la intervención psiquiátrica para volver a ser sujetos de sus propios itinerarios vitales. El artículo es resultado de un proceso etnográfico de 5 años de duración, el análisis de 20 programas radiofónicos y la realización de seis entrevistas en profundidad con participantes de la experiencia, y dos grupos focales en donde se debatieron las principales ideas surgidas de las entrevistas.

In the design and fabrication of any structural system for space application, balance between mass, stiffness and strength is crucial. Structures in space environments are exposed to high radiation levels and thermal shock, due to the sun irradiance and rotation around Earth. Therefore, accurate determination of the thermal and radiation properties is a key issue for the materials used in such applications. This study reports the thermal and mechanical performance of particle composites (epoxy resin and ZnO particles) after gamma and UV radiation. Composites are exposed to gamma and UV radiation at rates of 1 kGy and 10 kGy and characterized after exposure. For the evaluation, DMA, TGA and three-point bending mechanical test are performed to determine thermal properties and possible material degradation after radiation exposure. The incorporation of the filler in the thermal, radiation and mechanical response of the epoxy system improves as a function of its concentration. Then, epoxy resin reinforced with ZnO particles can be a potential candidate as a polymeric matrix for fiber-reinforced composites for nanosatellites.

Crop wild relatives’ genetic diversity is usually not considered in conservation planning. Here, the authors introduce an approach to identify conservation areas based on evolutionary and threat processes, by developing proxies of genetic differentiation, and including taxa’s habitat preferences.

Cervical cancer (CC) is the fourth leading cancer among women and is one of the principal gynecological malignancies. In the tumor microenvironment, cancer-associated fibroblasts (CAFs) play a crucial role during malignant progression, exhibiting a variety of heterogeneous phenotypes. CAFs express phenotypic markers like fibroblast activation protein (FAP), vimentin, S100A4, α-smooth muscle actin (αSMA), and functional markers such as MMP9. This study aimed to evaluate the protein expression of vimentin, S100A4, αSMA, FAP, and MMP9 in mesenchymal stem cells (MSC)-CAF cells, as well as in cervical cancer samples. MSC cells were stimulated with HeLa and SiHa tumor cell supernatants, followed by protein evaluation and cytokine profile to confirm differentiation towards a CAF phenotype. In addition, automated immunohistochemistry (IHQa) was performed to evaluate the expression of these proteins in CC samples at different stages. Our findings revealed a high expression of FAP in stimulated MSC cells, accompanied by the secretion of pro/anti-inflammatory cytokines. In the other hand, CC samples were observed to have high expression of FAP, vimentin, αSMA, and MMP9. Most importantly, there was a high expression of their activation proteins αSMA and FAP during the different stages. In the early stages, a myofibroblast-like phenotype (CAFs αSMA+ FAP+), and in the late stages a protumoral phenotype (CAF αSMA− FAP+). In summary, FAP has a crucial role in the activation of CAFs during cervical cancer progression.

Technological advances and the development of new and advanced materials allow the transition from three-dimensional (3D) printing to the innovation of four-dimensional (4D) printing. 3D printing is the process of precisely creating objects with complex shapes by depositing superimposed layers of material. Current 3D printing technology allows two or more filaments of different polymeric materials to be placed, which, together with the development of intelligent materials that change shape over time or under the action of an external stimulus, allow us to innovate and move toward an emerging area of research, innovative 4D printing technology. 4D printing makes it possible to manufacture actuators and sensors for various technological applications. Its most significant development is currently in the manufacture of intelligent textiles. The potential of 4D printing lies in modular manufacturing, where fabric-printed material interaction enables the creation of bio-inspired and biomimetic devices. The central part of this review summarizes the effect of the primary external stimuli on 4D textile materials, followed by the leading applications. Shape memory polymers attract current and potential opportunities in the textile industry to develop smart clothing for protection against extreme environments, auxiliary prostheses, smart splints or orthoses to assist the muscles in their medical recovery, and comfort devices. In the future, intelligent textiles will perform much more demanding roles, thus envisioning the application fields of 4D printing in the next decade.

Enquanto fenômeno socioestrutural inserido culturalmente na história humana, a violência de gênero é endêmica no mundo todo, atingindo mulheres das mais distintas classes, etnias, profissões, idades, etc. O problema, entretanto, é ainda mais crítico no Brasil, uma vez que pouquíssimos países no mundo têm um número tão elevado de crimes cometidos contra mulheres como o Estado brasileiro. Entre as mulheres mais vulneráveis a este problema estão as indígenas, que, não raras vezes, são vítimas de violências físicas e psíquicas, humilhações, estupros, entre outras. A violência por elas suportada é dúplice: intra e interétnica. Embora a Lei 11.340/06 seja o mais relevante instrumento legal do ordenamento brasileiro sobre a violência de gênero, uma vez que a norma foi redigida com base na realidade vivida pela mulher brasileira não indígena, apresenta importantes falhas quando é aplicada a casos de violência contra mulheres indígenas. Diante desses fatos, a presente pesquisa tem por objetivos contextualizar a grave realidade da violência de gênero existente no Brasil; apresentar as violências sofridas pelas mulheres indígenas; e, finalmente, apontar algumas das limitações no emprego da Lei nº 11.340 nos casos em que uma mulher indígena tenha sido vítima de violência de gênero. Como resultado, espera-se contribuir com a análise dos problemas que afetam as mulheres indígenas no Brasil, sobretudo sob o enfoque das violências de gênero interétnicas e intraétnica, das quais elas têm sido vitimadas ao longo dos séculos. Para alcançar o resultado proposto a pesquisa tem caráter exploratório e descritivo, utilizando-se o método dedutivo e as técnicas bibliográfica e documental.

Many studies have shown that air quality in cities is affected due to emissions of carbon from vehicles. As a result, policymakers (e.g., municipalities) intensely search for new ways to reduce air pollution due to its relation to health diseases. With this concern, connected vehicle technologies can leverage alternative on-road emissions control policies. The present investigation studies the impact on air pollution by (i) updating vehicles’ routes to avoid pollution exposure (route choice policy), (ii) updating vehicles’ speed limits (speed control policy), and (iii) considering electric vehicles (EVs). Vehicles are informed in advance about route conditions (i.e., on-road emissions) using the vehicular network. We found that by updating vehicle routes, 7.43% less CO emissions are produced within the evaluated region. Also, we find no evidence of significant emissions reductions in the case of limiting vehicles’ speed. Lastly, with 30% of EV penetration, safe CO emissions levels are reached.