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The synthesis and structure of 2,4,6,-tricyclobutyl-1,3,5-trioxane, C15H24O3 1, is described. It was formed in 39% yield during the work-up of the Swern oxidation of cyclobutylmethanol and may serve as a stable precursor of the cyclobutane carbaldehyde. The molecule of 1 occupies a special position (3.m) located at the center of its 1,3,5-trioxane ring. The latter is in a chair conformation, with the symmetry-independent O and C atoms deviating by 0.651 (4) Å from the least-squares plane of the other atoms of the trioxane ring. All three cyclobutane substituents, which have a butterfly conformation with an angle between the two planes of 25.7 (3)°, are in the cis conformation relative to the 1,3,5-trioxane ring. Intermolecular C—H...O interactions between the 1,3,5-trioxane rings consolidate the crystal structure, forming stacks along the c-axis direction. The crystal studied was refined a as a racemic twin.

In a one pot procedure , a series of novel Triazole linked thiazolidenone derivatives 8 a-g and 9 a-g was prepared by condensation of (3aR,5S,6R,6aR)- 6-((1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydro[2,3-d][1,3]dioxole-5- carbaldehyde 7 with mercapto acids and primary amines in presence of ZnCl2 under both micro wave irradiation and conventional heating conditions. Compound 7 prepared from di Acetone D- Glucose with oxidation followed by reduction , click reaction, primary acetonide deprotection and with oxidative cleavage .Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and anti bacterial activity of the compounds has also been evaluated.

A series of 4-hydroxyl-Δ2-isoxazol-6(6aH)-one derivatives was prepared by magnesium ion-mediated diastereoface-selective 1,3-dipolar cycloaddition of aromatic nitrile oxides with pyrrolidinone derivatives. The reaction of 4-hydroxyl-Δ2-isoxazol-6(6aH)-one derivatives with dimethylsulfoxide and oxalyl chloride under Swern conditions led to a Δ2-isoxazole-4,6(5H,6aH)-dione.

An improved synthesis of bicyclo[2.2.1]hept-5-ene-2,3-dione by Swern oxidation of bicyclo[2.2.1]hept-5-ene-2,3-diol, and an unexpected ring-opening reaction by the Swern oxidation of pyrazine-fused congeners are described.