1. Do immunosuppressive treatments influence immune responses against adenovirus-based COVID-19 vaccines in patients with multiple sclerosis? An Argentine multicenter study
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Berenice Anabel Silva, Esteban Miglietta, Juan Cruz Casabona, Shirley Wenker, María Bárbara Eizaguirre, Ricardo Alonso, Magdalena Casas, Luciana Grimanesa Lázaro, Federico Man, Gustavo Portuondo, Abril Lopez Bisso, Noelia Zavala, Federico Casales, Gastón Imhoff, Dra Judith Steinberg, Pablo Adrián López, Edgar Carnero Contentti, Norma Deri, Vladimiro Sinay, Javier Hryb, Edson Chiganer, Felisa Leguizamon, Verónica Tkachuk, Johana Bauer, Flavia Ferrandina, Susana Giachello, Paula Henestroza, Orlando Garcea, Carla Antonela Pascuale, Mauro Heitrich, Osvaldo L. Podhajcer, Sabrina Vinzón, Tomas D’Alotto-Moreno, Alejandro Benatar, Gabriel Adrián Rabinovich, Fernando J. Pitossi, and Carina C. Ferrari
- Subjects
multiple sclerosis ,vaccine ,immune response ,COVID - 19 ,cell response ,Omicron (BA.1) ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionThere are no reports in LATAM related to longitudinal humoral and cellular response to adenovirus based COVID-19 vaccines in people with Multiple Sclerosis (pwMS) under different disease modifying therapies (DMTs) and neutralization of the Omicron and Wuhan variants of SARS-COV-2.MethodsIgG anti- SARS-COV-2 spike titer were measured in a cohort of 101 pwMS under fingolimod, dimethyl fumarate, cladribine and antiCD20, as well as 28 healthy controls (HC) were measured 6 weeks after vaccination with 2nd dose (Sputnik V or AZD1222) and 3nd dose (homologous or heterologous schedule). Neutralizing capacity was against Omicron (BA.1) and Wuhan (D614G) variants and pseudotyped particles and Cellular response were analyzed.ResultsMultivariate regression analysis showed anti-cd20 (β= -,349, 95% CI: -3655.6 - -369.01, p=0.017) and fingolimod (β=-,399, 95% CI: -3363.8 - -250.9, p=0.023) treatments as an independent factor associated with low antibody response (r2 adjusted=0.157). After the 2nd dose we found a correlation between total and neutralizing titers against D614G (rho=0.6; p
- Published
- 2024
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