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Objective To analyze the risk factors of bleeding after subcutaneous injection of low-molecular-weight heparin in elderly patients with unstable angina pectoris and weakness. Methods Elderly patients with unstable angina pectoris and weakness who were hospitalized in the Department of Geriatrics and the Department of Cardiology of Nanjing Hospital Affiliated to Nanjing Medical University(Nanjing First Hospital) from June 2020 to June 2023, they were randomly divided into subcutaneous hemorrhage group(n=90) and control group(n=90) according to whether subcutaneous hemorrhage occurred.General data such as age, gender, body mass index(BMI), as well as combined diseases and injection methods were compared between the two groups.Multivariate logistic regression was performed to analyze the risk factors for subcutaneous hemorrhage after subcutaneous injection of low-molecular-weight heparin. Results The BMI, proportion of patients who underwent compression after injection of low-molecular-weight heparin, and subcutaneous fat thickness of patients in the subcutaneous hemorrhage group were significantly lower than those in the control group, with statistical significance(P