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Abstract Background Antenatal care (ANC) plays a crucial role in ensuring maternal and child safety and reducing adverse delivery outcomes. This study aimed to analyze the association between the quality of ANC and the occurrence of preterm birth and low birth weight in a sample of the population from 16 regions in 8 provinces in China. Methods Data from all closed cases of pregnant women and newborns reported in the Maternal and Child Health Monitoring System from January 1, 2018, to December 31, 2018, in 16 monitoring regions across 8 provinces in China were collected and included in the analysis, resulting in a total of 49,084 pregnant women and 49,026 newborns. Results The mean number of ANC visits was 6.95 ± 3.45. By percentage, 78.79% of the women received ANC examinations at least five times. The percentage of normative ANC examinations and the percentage of qualified ANC examinations was 30.98% and 8.0% respectively. The gestational age(χ2 = 229.305, p

This study investigated the potential impact of discharged water from the Bousfer desalination plant in Algeria on the marine environment, with a focus on sea urchins that we found overpopulated in the brine discharge area. To assess the presence of heavy metals, which can pose significant ecological and health risks, water samples were collected from the discharge area and analyzed using atomic absorption spectrometry (AAS). The targeted metals included iron, copper, zinc, nickel, and chromium. The results indicated extremely low concentrations of these metals, with values ranging from ≤0.001 to ≤0.01 mg/L. This research is the first of its kind at the Bousfer desalination plant and this site was chosen because this station is scheduled to be replaced by a much larger plant. This study suggests that the levels of heavy metals detected in discharged waters are insufficient to pose a direct threat to sea urchins or humans who consume them. However, given the potential for long-term and cumulative effects, further in-depth studies are needed to assess the overall environmental impact of discharged waters on marine ecosystems, including benthic fauna.

Abstract SUMOylation regulates numerous cellular stress responses, yet targets in the apoptotic machinery remain elusive. We show that a single, DNA damage-induced monoSUMOylation event controls PIDDosome (PIDD1/RAIDD/caspase-2) formation and apoptotic death in response to unresolved DNA interstrand crosslinks (ICLs). SUMO-1 conjugation occurs on conserved K879 in the PIDD1 death domain (DD); is catalyzed by PIAS1 and countered by SENP3; and is triggered by ATR phosphorylation of neighboring T788 in the PIDD1 DD, which enables PIAS1 docking. Phospho/SUMO-PIDD1 proteins are captured by nucleolar RAIDD monomers via a SUMO-interacting motif (SIM) in the RAIDD DD, thus compartmentalizing nascent PIDDosomes for caspase-2 recruitment. Denying SUMOylation or the SUMO-SIM interaction spares the onset of PIDDosome assembly but blocks its completion, thus eliminating the apoptotic response to ICL repair failure. Conversely, removal of SENP3 forces apoptosis, even in cells with tolerable ICL levels. SUMO-mediated PIDDosome control is also seen in response to DNA breaks but not supernumerary centrosomes. These results illuminate PIDDosome formation in space and time and identify a direct role for SUMOylation in the assembly of a major pro-apoptotic device.

Background: Chronic kidney disease (CKD) is becoming an increasing public health problem. A study that reviewed patients receiving treatment in hemodialysis centers reported 79.2% of patients from Jigawa State to be managed for CKD. This study aimed to find the factors associated with CKD among adults from high-burden kidney disease areas of Jigawa State. MATERIALS AND METHODS: A cross-sectional descriptive study design that utilized mixed methods (quantitative and qualitative) of data collection (sequential explanatory) was used to study eligible respondents from the four local government areas (LGAs) reported to have a high burden of kidney disease. The modified WHO STEPS questionnaire, key informant interview, and in-depth interview guides were employed to collect information from the eligible selected community members. Multistage and purposive sampling techniques were used, and data were analyzed using IBM SPSS version 22.0 with a statistical significance set at P ≤ 0.05. Thematic analysis was used to analyze the qualitative interviews. Results: The age of the respondents ranged from 18 to 102 years, with a median of 45 (interquartile range = 30–80) years. The period prevalence over the past five years (2018–2023) of having kidney disease in the family was 67 (18.6%), while the point prevalence (currently having a patient with kidney disease) was 51 (14.1%). In terms of the distribution of cases by LGAs, Jahun reported more cases, 33.3% in the family within the last five years, followed by Hadejia 18.7%. In the same vein, respondents from Jahun 28.9% and Hadejia 16.5% reported more current cases of kidney disease in the family. The prevalence of ever had patient with chronic kidney disease in the family was significantly higher among those with systolic hypertension (BP) ≥140 mmHg (29.3%, P < 0.001). Elevated systolic BP was significantly associated with currently having a kidney disease patient (23.3%, P = 0.001). The interviews revealed late presentation and noncompliance to medications among those with risk factors as the perceived facilitators of kidney disease. Conclusions: The prevalence of kidney disease was alarming in the high-burden kidney disease areas. The government should develop a sustainable model for mass community screening of risk factors and community-based health insurance to effectively manage all identified cases.

This research work focuses on the analysis of the impact of different parameters, such as the angular speed N1, the resistant torque M2 and the setting tension T of the timing belt on its operation. The main objective is to optimize the performance of the belt by understanding how these parameters influence its thermal behaviour. By carefully examining these factors, it becomes possible to identify the adjustments needed to improve the overall efficiency of the belt. An in-depth statistical analysis was conducted using three different approaches: analysis of variance (ANOVA), response surface method (RSM) and desirability function (DF) method, in order to examine the temperature of the heating of the belt T1 and its efficiency η. Data from the experiment are examined and manipulated to develop mathematical models that demonstrate the correlation between various parameters and growth rates. The results clearly demonstrate that the resistant couple M2 plays a preponderant role, with contributions of 55.25% and 69.82%, respectively. In addition, the N1 angular speed also has a significant influence, contributing 7.58% and 17.84%, respectively. On the other hand, setting tension T makes a small contribution to the temperature of belt T1. And a strong influence of 21.91% on their performance. These results clearly indicate that better efficiency can be obtained by reducing the angular speed N1 and increasing the resistive torque M2. These results show that the developed models have been well established and that there is a good correlation between the experimental and predicted data.

Historically, Algeria’s industry has significantly driven the country’s economic growth but has also become a notable contributor to carbon dioxide emissions. In an era where climate change threatens our world, understanding the role of sustainable economic development in mitigating environmental impacts is paramount. This study investigates the efficacy of sustainable economic development strategies in reducing CO2 emissions within Algeria’s industrial sector. Utilising an autoregressive distributed lag (ARDL) model to analyse data spanning 1990 to 2021, we explore the dynamic relationship between GDP per capita, industry value added, energy consumption, labour productivity, exports, and CO2 emissions. Our findings reveal that sustainable economic practices significantly reduce CO2 emissions in both the short and long term. The results advocate for a redefined approach to industrial policies, emphasising the potential of sustainable economic strategies to achieve a balance between economic growth and environmental preservation in Algeria and similar contexts globally.

The Spur-thighed tortoise has a large geographic distribution and can be infested by several tick species, mainly Hyalomma aegyptium. This tick has recently been confirmed as a natural carrier of numerous pathogenic, including zoonotic agents. The purpose of this study was to estimate the level of hard tick infestation in Mediterranean tortoises living in some regions of the west of Algeria (Oran, Mostaganem, and Tiaret) during the spring and summer of the year 2019. Among 39 turtles collected from the different study regions, 22 tested positive, which represents an infestation rate of 56.41 %. A total of 224 adult ticks and one nymph were collected, which can display a tick infestation intensity of 10.23 %. All of these ticks belong to a single species, which is Hyalomma aegyptium. In terms of abundance, this study showed 5.78 ticks/tortoise. Regarding sex, we have collected 198 male and 26 female ticks with a sex ratio of 7.62. The preferred attachment sites of Hyalomma aegyptium ticks were the inguinal, the limbs, and to a lesser degree, the neck. A few rare cases have been collected from the carapace. Further studies are needed to assess the impact of the intensity of H. aegyptium infestation on the tortoise’s health status and to assess the potential transmission of zoonotic pathogens.

The Community Multiscale Air Quality Model (CMAQ) is a local- to hemispheric-scale numerical air quality modeling system developed by the U.S. Environmental Protection Agency (USEPA) and supported by the Community Modeling and Analysis System (CMAS) center. CMAQ is used for regulatory purposes by the USEPA program offices and state and local air agencies and is also widely used by the broader global research community to simulate and understand complex air quality processes and for computational environmental fate and transport and climate and health impact studies. Leveraging state-of-the-science cloud computing resources for high-performance computing (HPC) applications, CMAQ is now available as a fully tested, publicly available technology stack (HPC cluster and software stack) for two major cloud service providers (CSPs). Specifically, CMAQ configurations and supporting materials have been developed for use on their HPC clusters, including extensive online documentation, tutorials and guidelines to scale and optimize air quality simulations using their services. These resources allow modelers to rapidly bring together CMAQ, cloud-hosted datasets, and visualization and evaluation tools on ephemeral clusters that can be deployed quickly and reliably worldwide. Described here are considerations in CMAQ version 5.3.3 cloud use and the supported resources for each CSP, presented through a benchmark application suite that was developed as an example of a typical simulation for testing and verifying components of the modeling system. The outcomes of this effort are to provide findings from performing CMAQ simulations on the cloud using popular vendor-provided resources, to enable the user community to adapt this for their own needs, and to identify specific areas of potential optimization with respect to storage and compute architectures.

Abstract Background Little is known about the trends in morbidity and mortality at the population level that followed the introduction of newer once-daily long-acting bronchodilators for COPD. The purpose of the study was to evaluate whether the availability of new bronchodilators was associated with changes in the temporal trends in severe COPD exacerbations and mortality between 2007 and 2018 in the older population with COPD; and whether this association was homogeneous across sex and socioeconomic status classes. Methods We used an interrupted time-series and three segments multivariate autoregressive models to evaluate the adjusted changes in slopes (i.e., trend effect) in monthly severe exacerbation and mortality rates after 03/2013 and 02/2015 compared to the tiotropium period (04/2007 to 02/2013). Cohorts of individuals > 65 years with COPD were created from the nationally representative database of the Quebec Integrated Chronic Disease Surveillance System in the province of Quebec, Canada. Whether these trends were similar for men and women and across different socioeconomic status classes was also assessed. Results There were 130,750 hospitalizations for severe exacerbation and 104,460 deaths, including 24,457 (23.4%) respiratory-related deaths, over the study period (928,934 person-years). Significant changes in trends were seen after 03/2013 for all-cause mortality (-1.14%/month;95%CI -1.90% to -0.38%), which further decreased after 02/2015 (-1.78%/month;95%CI -2.70% to -0.38%). Decreases in respiratory-related mortality (-2.45%/month;95%CI -4.38% to -0.47%) and severe exacerbation (-1,90%/month;95%CI -3.04% to -0.75%) rates were only observed after 02/2015. These observations tended to be more pronounced in women than in men and in higher socioeconomic status groups (less deprived) than in lower socioeconomic status groups (more deprived). Conclusions The arrival of newer bronchodilators was chronologically associated with reduced trends in severe exacerbation, all-cause and respiratory-related mortality rates among people with COPD > 65 years. Our findings document population benefits on key patient-relevant outcomes in the years following the introduction of newer once-daily long-acting bronchodilators and their combinations, which were likely multifactorial. Public health efforts should focus on closing the gap between lower and higher socioeconomic status groups.

Solitary fibrous tumors (SFTs) are rare neoplasms that can occur in various locations, including the central nervous system (CNS). We present a case report of a 47-year-old male patient with an intracranial SFT who underwent subtotal resection followed by adjuvant radiotherapy. The patient initially presented with chronic left temporal headache and was diagnosed with an intra-axial double-component mass in the left temporoparietal lobe. Histopathological examination confirmed the diagnosis of SFT, and immunohistochemical staining demonstrated positivity for CD34, Bcl-2, and STAT6. Following the incomplete resection, the patient received adjuvant radiotherapy using volumetric modulated arc therapy (VMAT) technique. During radiotherapy, the patient experienced a spontaneous encephalocele rupture but recovered without complications. One year postradiotherapy, the patient showed no recurrence of symptoms or radiological evidence of tumor recurrence. This case highlights the challenges in the diagnosis and management of CNS SFTs and suggests that subtotal resection followed by adjuvant radiotherapy may be an effective treatment approach in achieving favorable outcomes for these rare neoplasms.

Helicobacter pylori, a bacterial pathogen that causes severe gastric diseases, has developed antibiotics resistance; mainly against clarithromycin. Consequently, the latest international recommendations have advised clarithromycin susceptibility testing before prescribing the first line of therapy. This resistance is predominantly related to the A2143G point mutation of 23S rRNA. The aim of this study was to develop a highly sensitive and cheap molecular technique to detect H. pylori clarithromycin resistant strains. For that, plasmids of H. pylori 23S rRNA region harboring A2143G point mutation were constructed and used to develop polymerase chain reaction coupled with a high-resolution melting technique (PCR-HRM). Then, this method was applied on 233 gastric H. pylori positive samples. The obtained results showed that the developed PCR-HRM technique allowed specific identification of clarithromycin resistant and heteroresistant H. pylori samples, even if the ratio of resistant/ sensitive samples was low. In this series, the detected rate of H. pylori clarithromycin resistance was 7.6 %, which concord with the resistance rate determined using molecular sequencing. So, the developed PCR-HRM represents a good tool for detecting resistant and sensitive H. pylori samples and can be used in routine clinical practices. This will help in managing H. pylori infection, increase its eradication rate, and avoid the use of therapeutic protocols that have serious side effects.

The present study analyzed the effect of temperature, pH, pre-treatment and mixing ratio on the anaerobic digestion process. The parameters during the anaerobic co-digestion of cow manure and food waste were then optimized using the Taguchi experimental design method. ANOVA was carried out to find the significant parameters which influence biogas production. Experimental tests were carried out at laboratory-scale reactors kept at different temperatures (28 °C, 35 °C, and 50 °C). The specific methanogenic performance (SMP) during anaerobic digestion at higher temperatures was characterized with the analysis of acetate, propionate, butyrate, hydrogen, glucose, and formate, and was validated with the literature. The improvement of biogas production with different pre-treatments, i.e., ultrasonic, autoclave, and microwave techniques, was also analyzed. The results showed that the reactor that was maintained at 35 °C showed the highest biogas production, while the reactor that was maintained at a lower temperature (28 °C) produced the lower volume of biogas. As the retention time increases, the amount of biogas production increases. Methanogenic activities of microorganisms were reduced at higher temperature conditions (65 °C). Biogas production increased by 28.1%, 20.23%, and 13.27% when the substrates were treated with ultrasonic, autoclave, and microwave, respectively, compared to the untreated substrate. The optimized condition for the highest biogas production during anaerobic co-digestion of food waste and cow manure is a temperature of 35 °C, a pH of 7 and a mixing ratio (CM:FW = 1.5:0.5). ANOVA showed that temperature is the most important input parameter affecting biogas production, followed by mixing ratio.

The impacts of climate change and soil erosion are significantly affecting agriculture in non-developed countries. In Mali, a country located in Western Africa, there is a drastic reduction in available fertile arable lands and water scarcity, which is damaging rural communities and affecting the development of vital infrastructures, consequently, decreasing people’s incomes. There is a lack of information about the perception of these challenges among the small rural communities and the possible adaptation strategies can be applied. Therefore, the main aim of this study was to determine local farmer perceptions of climate change, soil erosion, and adaptation strategies conducting a survey among 200 farmers in 10 villages within the rural municipality of Méguétan, serving as a representative study case. Our results showed that farmers are aware of the challenges related to climate change and soil erosion and are willing to adopt some measures but conditioned by a range of traditional techniques. The most common strategies are: changing the sowing calendar, diversifying crops, using resistant varieties, having an alternative income, and following weather forecasts on the radio. Stone rows remain the most widely adopted technique to reduce soil erosion, with a knowledge rate of 88% and an application about 29%. The study also highlighted the increasing vulnerability of farmers to climate change and soil erosion due to insufficient material and financial resources. We conclude policies should pay attention to services and partners that invest more funds in technical assistance to strengthen adaptation strategies and teach the population, considering nature-based solutions.

Background: Dysglycaemia and diabetes mellitus (DM) are important and preventable risk factors associated with kidney diseases, cardiovascular complications, and mortality worldwide. Aim: This study aimed to identify the prevalence and factors associated with dysglycaemia and diabetes among adults in high-burden kidney disease areas of Jigawa State, Northwest Nigeria. Methods: A cross-sectional survey of representative sample of 361 adults, aged ≥18 years, was conducted in four local government areas (LGAs) of Jigawa State, considered to have a high burden of kidney disease requiring hemodialysis. Data were collected using a modified World Health Organization STEPS questionnaire using a multistage sampling technique and were analyzed using IBM SPSS Statistics for Windows, version 22.0, with statistical significance set at P ≤ 0.05. Results: The minimum age of the respondents was 18 and the maximum was 102 with a median of 45 (interquartile range = 30–80) years. The majority of the respondents 89.5% were >24 years of age. The prevalence of dysglycemia and DM in the high-burden LGAs was 10.5% and 3.6%, respectively. Dutse LGA had the highest prevalence of dysglycemia 16.7%, followed by Hadejia LGA with a prevalence of 12.2%. On the other hand, Hadejia LGA had the highest prevalence of DM 7.7%, followed by Jahun LGA with a prevalence of 3.3%. Age ≥40 years, family histories of diabetes, being overweight, alcohol ingestion, and previous blood sugar tests were identified as factors associated with DM. The odds of developing diabetes were significantly higher among those with a reported history of alcohol consumption, family history of diabetes, and overweight. Conclusion: Dysglycaemia and diabetes are significant public health problems, and many people who have the conditions are unaware they have them. Family history of diabetes, alcohol ingestion, and overweight are important risk factors. The government and all the relevant stakeholders should prioritize community screening and other relevant interventions for early detection and timely management of cases.

Ground observations are often considered as the most reliable and precise source of precipitation data. However, long-term precipitation data from ground observations are lacking in many parts of the world. Gridded precipitation products (GPPs) therefore have emerged as crucial alternatives to ground observations, but it is essential to assess their capability to accurately replicate precipitation patterns. This study aims to evaluate the performance of five GPPs, NASA POWER, TerraClimate, Climate Hazards Group Infrared Precipitation with Climate Data (CHIRPS), GPCC, and Climate Research Unit (CRU), in capturing precipitation and drought patterns from 1981 to 2021 in Yobe, Nigeria. The results indicate that GPCC had good performance at both monthly and annual scales, with high correlation coefficients and low error values. However, it tends to underestimate precipitation amounts in certain areas. Other products also exhibit satisfactory performance with moderate correlations with ground observations. Drought analysis indicates that GPCC outperforms other products in standardised precipitation index-6 calculations, while NASA POWER demonstrates inconsistencies with ground observations, particularly during the early 1980s and mid-2000s. In conclusion, GPCC is the most preferable GPP for precipitation and drought analysis in the Yobe State in Nigeria. HIGHLIGHTS Evaluation of five gridded precipitation products (GPPs) in northern Nigeria.; GPPs captured monthly precipitation better than annual precipitation.; GPPs underestimated precipitation in the western Yobe.; GPCC performed better than other GPPs in Kobe, Nigeria.; GPCC and Climate Research Unit are suitable for calculating the standardised precipitation index-6 index.;

Housing represents the initial place where each individual has the opportunity to reconnect with their identity. It should offer every family the opportunity to live according to their lifestyle. Most people aspire to a living space that reflects both their aspirations and their way of life, while also taking into account the demands of everyday life. Since independence, Algeria has shown a remarkable commitment to promoting social housing, mobilising significant efforts in this area. However, what has been observed is that professionals design housing that occupants adapt to their daily needs. Despite the in-depth analyses by numerous researchers revealing the significance of these transformations, professionals persist in reproducing the same spatial patterns, thus demonstrating a certain indifference towards the work of academic research. Residents have tried to adapt to these housing units by making modifications to gain more space both inside and out. Inside, these transformations were appreciated by the occupants. From the outside, these remodellings have had a negative impact on the overall image of the city. The balance between quantity and quality was not taken into account, even though the aim of rapid construction was to alleviate pressure on the housing market. This article aims to question occupants' practices to establish a link between the housing designed and built, and occupants' expectations. The analytical approach used is post occupancy evaluation (POE) - a multi-method approach to data collection that includes direct observation, plan analysis and questionnaire. The housing units studied were not selected according to any particular method but rather chosen on the basis of the residents who agreed to answer the questions and share their lifestyle and expectations regarding their housing. Data processing, through a comparison between the initial plan drawn up by the designer and the current plan modified by the inhabitant, enabled us to deduce the discrepancies that exist between the two plans and to understand the modes of appropriation of the housing's interior space.

Abstract Intestinal parasitic infections (IPIs) can lead to significant morbidity and mortality in cancer patients. While they are unlikely to cause severe disease and are self-limiting in healthy individuals, cancer patients are especially susceptible to opportunistic parasitic infections. The gut microbiota plays a crucial role in various aspects of health, including immune regulation and metabolic processes. Parasites occupy the same environment as bacteria in the gut. Recent research suggests intestinal parasites can disrupt the normal balance of the gut microbiota. However, there is limited understanding of this co-infection dynamic among cancer patients in Malaysia. A study was conducted to determine the prevalence and relationship between intestinal parasites and gut microbiota composition in cancer patients. Stool samples from 134 cancer patients undergoing active treatment or newly diagnosed were collected and examined for the presence of intestinal parasites and gut microbiota composition. The study also involved 17 healthy individuals for comparison and control. Sequencing with 16S RNA at the V3–V4 region was used to determine the gut microbial composition between infected and non-infected cancer patients and healthy control subjects. The overall prevalence of IPIs among cancer patients was found to be 32.8%. Microsporidia spp. Accounted for the highest percentage at 20.1%, followed by Entamoeba spp. (3.7%), Cryptosporidium spp. (3.0%), Cyclospora spp. (2.2%), and Ascaris lumbricoides (0.8%). None of the health control subjects tested positive for intestinal parasites. The sequencing data analysis revealed that the gut microbiota diversity and composition were significantly different in cancer patients than in healthy controls (p

In this study, the Senegal River, being the main source of water, plays a crucial role in the area’s agricultural development. Irrigation on the M’Pourie plain using water from the Senegal River is carried out without any prior sanitation control. An evaluation of the quality of irrigation water and its impact on soil salinization in different agricultural plots soil salinity is crucial for the effective utilization of traditional irrigation water over extended periods. Comprehensive physico-chemical analyses were conducted across nine locations on the M’Pourie plain in Rosso during the dynamic seasons of 2021-2023. Nevertheless, a relatively small number of studies have employed soil salinity indexing methods to examine the consequences of river irrigation on soil salinity. The analysis and interpretation of the results obtained were based both on classic methods (average and correlations) and more advanced techniques such as principal component analysis (PCA) and the Piper diagram which allow characterization and a spatial typology of water. Analysis of the Piper diagram highlights the distinction between two groups of water, weakly and moderately mineralized, ranging from 52.22 μS.cm-1 in the dry season to 72.22 μS.cm-1 in the rainy season, presenting a sodium-potassium bicarbonate facies The variability of irrigation water supplies, proves to be important in the functioning of an agro-systems. Two modes of operation have become individualized: the dry phase mode, characterized by very strong mineralization of the water linked to a significant load of dissolved elements, and the wet phase mode, whose water quality is poorly mineralized but shows the impact that its irrigation water can represent in the loading of organic and mineral pollution and the need for strict control of these waters upstream before their agricultural use. The results of this study show the absence of risks of soil salinization in relation to the chemical nature of irrigation water and the impact of agriculture on the M’Pourie plain.

Securing sustainable access to water resources is a critical concern for all nations bordering the Mediterranean Sea, and Algeria is no exception. Leveraging its extensive 1,200-kilometer coastline, Algeria has embraced desalination as a key strategy, treating both seawater and brackish water sources. This approach provides potable water to inland towns and cities, extending as far as 60 kilometers from the coast. Currently, Algeria boasts an impressive network of 21 desalination plants, with a combined daily production capacity of 2.6 million cubic meters. The majority of these facilities utilize reverse osmosis, a widely employed desalination technology. This study focused on the Bousfer mini-desalination plant situated on Algeria's western coast. Various water samples were analyzed throughout the desalination process: seawater intake, post-desalination (osmosis) water, remineralized drinking water, and the resulting brine wastewater. A physicochemical and bacteriological analysis was conducted to assess water quality at each stage. Statistical comparisons were performed using paired-sample T-tests for seawater and osmosis water, and one-sample T-tests were used to compare drinking water and wastewater against established international standards. The analysis revealed significant reductions (p-value < 0.001) in most physicochemical parameters for the reverse osmosis water, including conductivity, total dissolved solids (TDS), alkalinity, total hardness, chlorides, calcium, and magnesium. Conversely, these parameters were significantly elevated in the brine wastewater. The bacteriological analysis confirmed the absence of harmful bacteria like E. coli, enterococci, and sulphite-reducing clostridia in the final drinking water. However, this study also highlighted a negative environmental externality, the presence of debris and foam layers on the water surface near the desalination plant outlet, attributed to chemical discharges, which poses a potential nuisance for tourists visiting nearby Bousfer beaches.

Abstract Cholangiocarcinoma (CCA) was identified as a malignant tumor with rising incidence and mortality rates, and the roles of long noncoding RNA (lncRNA) in CCA remained not entirely clear. In this study, LINC00511 had high expression in CCA, which was closely related to poor prognosis. Knockdown of LINC00511 significantly inhibited cell malignant biological behaviors. It also affected the stemness of CCA, evidenced by decreased SOX2 protein expression. Moreover, the study revealed the interaction of LINC00511, YTHDF2, and SOX2 in CCA. Specifically, LINC00511 facilitated the formation of a complex with YTHDF2 on SOX2 mRNA, which uniquely enhances the mRNA's stability through m6A methylation sites. This stabilization appears crucial for maintaining malignant behaviors in CCA cells. Additionally, LINC00511 modulated SOX2 expression via the PI3K/AKT signaling pathway. Meanwhile, SOX2 can also promote LINC00511 expression as an upstream transcription factor, thereby confirming a positive feedback loop formed by LINC00511, YTHDF2, and SOX2, which plays a significant role in the occurrence and development of CCA. Finally, the study successfully constructed two patient‐derived xenograft models, revealing the vital role of LINC00511 in CCA development. In summary, this research provides a comprehensive understanding of the role of LINC00511 in the pathogenesis of CCA.

Background: Membranous nephropathy (MN) is characterized by immune complex deposition in the glomerular basement membrane, leading to proteinuria and potentially progressive renal dysfunction. Fibroblasts have been implicated in the pathogenesis of MN through their involvement in tissue remodeling and immune modulation. Methods: We employed integrated bioinformatics analyses to identify fibroblast-associated biomarkers and molecular subtypes in MN. The xCell algorithm was used to assess fibroblast infiltration, and weighted gene co-expression network analysis (WGCNA) identified fibroblast-related gene modules. Differentially expressed fibroblast-associated genes (DEFAGs) were screened between MN and healthy controls (HC) using differential expression analysis and protein-protein interaction (PPI) network construction. Consensus clustering categorized MN patients into distinct subtypes based on DEFAG expression profiles. Results: Fibroblast scores were a significant elevation in MN compared to HC, indicating increased fibroblast involvement in MN pathogenesis. WGCNA identified 13 fibroblast-related gene modules, with the brown and turquoise modules showing strong correlation with fibroblast scores (correlation coefficient = 0.79 and 0.75, respectively, p

BackgroundPoint of care hemoglobin meters play key roles in increasing access to anemia screening in antenatal care especially in settings with limited access to laboratories. We aimed to determine the diagnostic accuracy of a non-invasive spot-check hemoglobin (SpHb) meter, Masimo Rad-67® Pulse CO-Oximeter®, in the diagnosis of anemia in pregnant women attending antenatal care clinics in Kilifi, Kenya.MethodsThis was a diagnostic accuracy study that retrospectively evaluated SpHb against a validated reference standard of laboratory assessed hemoglobin (Lab Hb) by a SYSMEX XN-330 automated hematology analyzer. The study was nested within a prospective pregnancy cohort study that recruited unselected pregnant women from antenatal care clinics in two public hospitals in Kilifi County, coastal Kenya. Records with both SpHb and Lab Hb were selected from pregnancy visits between May 2021 and December 2022. Linear regression and Bland-Altman analysis were performed to compare the two tests and diagnostic accuracy parameters obtained for the diagnosis of anemia.ResultsA total of 2,975 records (from 2,203 unique participants), with paired SpHb and Lab Hb were analyzed. Linear regression showed a significant but weak positive correlation, a proportional bias of 0.44 (95% CI 0.41–0.47) and a constant of 7.59 (95% CI 7.30–7.87, p

Cartilage defect is one of the common tissue defect clinical diseases and may finally lead to osteoarthritis (OA) which threat patients’ physical and psychological health. Polysaccharide is the main component of extracellular matrix (ECM) in cartilage tissue. In the past decades, polysaccharide-based hydrogels have shown great potential for cartilage regeneration considering unique qualities such as biocompatibility, enhanced cell proliferation, drug delivery, low toxicity, and many others. Structures such as chain length and chain branching make polysaccharides have different physical and chemical properties. In this review, cartilage diseases and current treatment options of polysaccharide-based hydrogels for cartilage defection repair were illustrated. We focus on how components and structures of recently developed materials affect the performance. The challenges and perspectives for polysaccharide-based hydrogels in cartilage repair and regeneration were also discussed in depth.

The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with the 2020 Nobel Prize in Chemistry, has garnered significant attention for its precision in editing genomes. However, the CRISPR system faces challenges when applied in vivo, including low delivery efficiency, off‐target effects, and instability. To address these challenges, innovative technologies for targeted and precise delivery of CRISPR have emerged. Engineered carrier platforms represent a substantial advancement, improving stability, precision, and reducing the side effects associated with genome editing. These platforms facilitate efficient local and systemic genome engineering of various tissues and cells, including immune cells. This review explores recent advances, benefits, and challenges of CRISPR‐based genome editing delivery. It examines various carriers including nanocarriers (polymeric, lipid‐derived, metallic, and bionanoparticles), viral particles, virus‐like particles, and exosomes, providing insights into their clinical utility and future prospects.

Objective To describe antibiotic prescribing practices using the WHO AWaRe (Access, Watch, Reserve) classification in West African children under 5 years of age attending public primary health centres (PHCs).Design Cross-sectional study.Setting The AIRE project implemented the systematic use of pulse oximetry into integrated management of childhood illness consultations in West African countries (Burkina Faso, Guinea, Mali and Niger). We described antibiotic prescriptions for outpatient children at 16 PHCs and for severe cases referred at district hospitals.Patients Between 14 June 2021 and 19 June 2022, 15 854 outpatients were included: 968 neonates and young infants (0–28 days) and 14 886 children (2–59 months). Among them, 78 (8.1%) neonates and young infants and 385 (2.6%) children were hospitalised. We evaluated 58 hospitalised neonates and young infants and 275 hospitalised children, respectively.Main outcome measures Frequency of antibiotic prescriptions according to the AWaRe classification recommended by WHO.Results At the PHC level, proportions of neonates and young infants with ≥1 antibiotic prescription were 83%, 62%, 71% and 59% in Burkina Faso, Guinea, Mali and Niger, respectively. A total of 805 antibiotics were prescribed (85% Access and 13% Watch). The proportions of children with ≥1 antibiotic prescription reached 71%, 66%, 63% and 36% in Burkina Faso, Guinea, Mali and Niger, respectively. Out of the 9630 antibiotics prescribed, 93% were Access (mainly amoxicillin), and 7% Watch. At the hospital level, Watch antibiotics were mainly prescribed for severe cases referred. No Reserve antibiotics were prescribed.Conclusions High proportions of antibiotics were prescribed to outpatient children included, the appropriateness of which needs further study. Nevertheless, in every country, the proportion prescribed in the Access group reached the minimum threshold of 60% of all antibiotic prescriptions, as recommended by WHO.Trial registration number PACTR202206525204526.

In recent years, there has been a significant trend to improve poultry zootechnical performances by biological methods to avoid the unwanted chemical growth factor's introduction into breeding process. Medicinal plants and their derivatives are good candidates to achieve this goal. Thus, this work aimed at evaluating the effect of poultry feed supplementation with the spices Curcuma longa and Zingiber officinale on the zootechnical performance, serological, and microbiological parameters of Ross 308 chicken. To achieve this purpose, 180 chicks divided into five groups and reared for 12 days. The experimental groups consisted of a control group receiving a conventional feed without antibiotics and four groups receiving a conventional feed with 0.5 and 1% turmeric and ginger doses, respectively. Results of the experiment revealed that supplementing the feed with 0.5% turmeric powder increased live weight, and average daily gain and decreased feed conversion compared to the other groups. Turmeric powder supplement (0.5 and 1%) affected blood serum parameters by decreasing triglyceride and aspartate aminotransferase (AST) concentrations. In comparison, the incorporation of 0.5% ginger in the diet decreased triglyceride concentrations, cholesterol, aspartate aminotransferases (ASAT), and alanine aminotransferases (ALAT). Cecum bacteriological analysis showed a total absence of coliforms, Salmonella sp., Clostridium sp., and lactic acid bacteria in the chick groups supplemented with different doses of turmeric and ginger (0.5 and 1%, respectively). Within this study’s limits, using these two studied spices as additives in poultry feed allowed us to conclude that supplementing with 0.5% turmeric powder positively impacted the evaluated parameters.

Fusarium is a soil-borne pathogen that poses a serious threat to the quality and yield of hundreds of crops worldwide, particularly tobacco production. Using metabolomics technology, we investigated natural metabolites from disease-conducting soil (DCS) and disease-suppressing soil (DSS) of tobacco rhizosphere as fungicides to control tobacco Fusarium wilt (TFW), which is mainly caused by Fusarium oxysporum. Furthermore, the antifungal mechanisms of these natural metabolites were preliminarily elucidated through various assessments, including antifungal activity determination, chemotaxis effect tests, PI staining experiments, and measurements of extracellular conductivity and protein content. Metabolomics results showed that the DCS with three different disease grades (G1, G5 and G9 groups) had significantly higher levels of 15, 14 and 233 differential rhizosphere metabolites (DRMs) and significantly lower levels of 72, 152 and 170 DRMs compared to the DSS (G0 group). According to KEGG pathway analysis, these DRMs were found to be enriched in the caffeine metabolism, biosynthesis of phenylpropanoids, galactose metabolism and tyrosine metabolism, etc. Linustatin, scopoletin and phenylpropiolic acid were picked out from these DRMs and found to have suppressive activity against F. oxysporum through correlation analysis and antifungal experiments. The three DRMs showed strong inhibitory effects on the growth and spore germination of F. oxysporum at concentrations of 0.5 mM or higher in each test period. Furthermore, F. oxysporum showed a phobotaxis effect against these three DRMs at concentrations as low as 0.25 mM. Finally, we found that the three DRMs had an inhibitory effect on F. oxysporum by destroying the integrity of the cell membrane and increasing the membrane permeability of F. oxysporum. This study firstly reports the inhibition activity of phenylpropiolic acid and linustatin on F. oxysporum, providing a practical and environmentally friendly method for biocontrol of TFW by using natural fungicides.

Opaque surfaces, such as walls, are well-known for their significant contributions to heat loss and energy demands in buildings. However, transparent surfaces, such as windows, are equally critical to a building's energy performance. The design of these transparent elements requires a careful balance of various factors, including window size, glazing type, and orientation, each of which plays a pivotal role in enhancing energy efficiency. This study explores the optimization of these factors during the design process, emphasizing their impact on the overall building performance.This research evaluates the potential energy savings in a building archetype representative of the Algerian building stock. Utilizing the EnergyPlus simulation tool, the study conducted 1152 simulations on a baseline model to generate a comprehensive dataset detailing the building's energy demands for heating and cooling across various climatic conditions. The findings reveal that annual energy savings for this type of housing essentially depend on its climatic zone and can range from 6.92 % for a hot semi-arid climate (Bsh) to reach a maximum of 9.75 % in a cold semi-arid climate (Bsk), a window-to-wall ratio (WWR) of 60 % typically maximizes energy efficiency, low-E glazing proved most effective in most cases, although regions needing significant solar protection favored alternative glazing types. Optimal window orientation generally trends Eastward, except in regions where southern exposure better supports solar management, highlighting the complex relationship between architectural design choices and energy efficiency.

The optimization of the active control system is pivotal in achieving an acceptable performance level while minimizing control costs. The optimal location of actuators, efficient control force, and adequate vibration reduction are critical objectives in control system optimization. This study introduces a novel optimization algorithm, the Population-Guided and Modified Reference-Point Based Non-Dominated Sorting Genetic Algorithm-II (PMR-NSGA-II), tailored for actuator placement and tuning that incorporates input and output user preference. The analysis focuses on optimizing the vibration control of a 20-story steel frame building. The PMR-NSGA-II could reduce the computational expenses of three objectives optimization by guiding the initial population using prospective population prediction and orienting the search towards a reference point. The pre-calculated input energy distribution guides the determination of the prospective initial population. The reference point, along with the allowable drift and actuator capacity constraints, focuses the search process to efficiently obtain the Pareto fronts with less effort wasted to explore the less preferred areas in the search space. The non-dominated sorting and elitist operators are also employed to fasten the convergence. The structural analysis is conducted via non-linear time history analysis with seven ground motions considered. The PMR-NSGA-II exhibits significant computational efficiency in the active control system optimization. Results demonstrate that PMR-NSGA-II could provide the near-optimal solution closest to the reference point with a smaller population size and a faster convergence rate than the NSGA-II. The computational time per generation of the proposed PMR-NSGA-II is 1.36 to 2.43 times faster than NSGA-II for the seven ground motions analyzed. By applying PMR-NSGA-II, the number of individuals that need to be assessed to reach convergence is reduced by 50 % to 88 % compared to NSGA-II. Ultimately, the near-optimal configurations could significantly reduce the building responses and increase the performance level of the building based on FEMA 356 and ASCE 41 acceptance criteria.

Abstract Introduction Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women’s adherence and increase screening rates. Methods This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.

The global shift from conventional energy sources to sustainable alternatives has garnered significant attention, driven by the promise of economic benefits and environmental sustainability. The current study rigorously investigated the economic advantages and sustainability achieved from the transition of households in Mauritania from liquefied petroleum gas (LPG) to biogas utilization. The study constitutes a robust case study that centers on assessing the multifaceted impacts of this transition on household finances and overall quality of life in Mauritania. This case focuses on biogas technology adoption and its role as a competitor of LPG in Mauritania. The energy poverty portfolio of the nation has been explored and livestock waste generation and biogas production potential have been estimated at 2451 million cubic meters annually. Biogas production can fulfill 50% of the energy requirement for cooking purposes within the country. The community scale fixed-dome-type biogas digesters have been recommended for Mauritania by considering a community of 100 families. The calculated payback period for the community project is 74 months, and after the payback period, continuous monthly benefits of USD 1750 will be started. Livestock manure is directly utilized for farming practices in Mauritania, which produces 10.7 Gg of methane emissions per year. Biogas production is a clean and economically viable option for Mauritania, which can also be beneficial for reducing the methane emissions footprints of the livestock sector. This case study will prove as a vital project for other African nations if successfully implemented. Multiple recommendations for the policy-makers of Mauritania have also been formulated, like tariffs on biogas production facilities and swift financing schemes, which can further strengthen the biogas production on a national scale. International funders should also take part in coping with the energy demand of Mauritania and its mission to mitigate climate change rather than utilizing LPG on a national scale. Biogas production and utilization are much cheaper compared with the fluctuating prices of LPG and ensure health when cooking.

Objective·To investigate the pathological and physiological changes underlying noise-induced cochlear nucleus damage and the regulating function of astrocytes on the damage, using a combination of morphological analysis, and molecular biology techniques.Methods·Forty-eight male C57BL/6J mice were randomly divided into two groups and exposed to 110 dB SPL (sound pressure level) broadband noise for 2 hours. Auditory brainstem response (ABR) tests were performed on the mice on days 1, 7, 14, 30, and 90 after the noise exposure. Immunofluorescence staining of cochlear nuclear tissue was conducted to observe cochlear nuclear neurons and auditory synapses, as well as astrocyte activation levels. In addition, the damage to the cochlear nuclear neurons and synapses caused by noise was verified through Western blotting.Results·A significant decrease in cochlear nuclear Bushy cells after noise exposure was observed. The Western blotting results showed that there was severe loss of nerve fibers in cochlear nuclear neurons, indicating that noise caused significant damage to cochlear nucleus neurons. Moreover, a significant loss of auditory synapses labeled with vesicular glutamate transporter 1 (Vglut1) was observed, which was the severest on day 14 after noise exposure and slowly recovered on day 90. Interestingly, astrocytes in the cochlear nucleus displayed obvious clustering and activation after noise exposure. By staining with glial fibrillary acidic protein (GFAP), most astrocytes were distributed around the cochlear nucleus, granule cell area, and auditory nerve root before noise exposure, and they had a small size. However, on day 14 after noise exposure, a large number of activated astrocytes aggregated in the ventral cochlear nucleus, and they all showed a pattern of growth around the synapses.Conclusion·Noise exposure leads to significant damage in the cochlear nucleus, and it is possible that astrocytes are involved in its damage and repair processes. These findings will provide a crucial foundation for further understanding the mechanisms of sound signal analysis, integration, and neural plasticity in the cochlear nucleus.

Abstract Objective To assess the prevalence of anemia among pregnant women across their entire pregnancy and the factors affecting it in the monitoring areas. Methods A total of 108,351 pregnant women who received antenatal health care and delivered from January 1, 2016 to December 31, 2020 in 15 monitoring counties of 8 provinces in the Maternal and Newborn Health Monitoring Program (MNHMP) of National Center for Women and Children’s Health (NCWCH) were selected as the study subjects. The anemia status among the subjects across their first, second and third trimester of pregnancy and the influencing factors were analyzed. Results From 2016 to 2020, the prevalence of anemia at any stage during pregnancy in the monitoring areas was 43.59%. The prevalence of anemia among pregnant women across all three trimesters was 3.95%, and the prevalence of mild and moderate-to-severe anemia was 1.04% and 2.90%, respectively. Protective factors were living in the northern area (OR = 0.395) and being a member of an ethnic minority (OR = 0.632). The risk factors were residing in rural areas (OR = 1.207), with no more than junior high school education (OR = 1.203), having ≥ 3 gravidities (OR = 1.195) and multiple fetuses (OR = 1.478). Conclusions Although the prevalence of anemia among pregnant women across all trimesters in the monitoring area was low, the severity of anemia was high. Since the prevalence of anemia among pregnant women across their entire pregnancy in the monitoring area is affected by many different factors, more attention should be paid to pregnant women living in rural areas, with low literacy, ≥ 3 gravidities and multiple fetuses for early intervention.

Abstract Background The intake of nutrient-rich foods from diverse diets ensures adequate nutrition for women. This study aims to determine dietary diversity among women of reproductive age (WRA) using the MDD-W indicator and how it relates to their socio-economic characteristics in the city of Nouakchott, Mauritania. Methods A community-based cross-sectional study was conducted on 240 women of reproductive age, aged 15–49 years. Food consumption data were obtained through unquantified 24 h recall which is designed to identify all foods consumed by the women during this period. We computed MDD-W as the consumption of at least five out of ten predefined food groups according to the guideline of the Food and Agriculture Organization (FAO) of the United Nations. In order to determine which factors had a statistically significant influence on dietary diversity among women, we used a value of P

Lungworm infections are known to be frequent and responsible for substantial economic losses in ruminants. They are caused by Dictyocaulus filaria and various species belonging to the Protostrongylidae family of nematodes. This present study was conducted at the Tiaret municipal slaughterhouse and the parasitology laboratory of the veterinary institute for six months, from November 2016 to April 2017. The study aimed to evaluate the occurrence of lungworm infections and the determination of the circulating species affecting sheep in the region with a pathological study of infected pulmonary tissue sections. The overall incidence of the pathology in sheep was 26 % (240/921). The identified species were Muellerius capillaris 43 %, Neostrongylus linearis 8 %, Cystocaulus ocreatus 4 %, Dictyocaulus filaria 3 %, Protostrongylus rufescens 1 %, and mixed infestations 42 %. The histological examination of corresponding lesions has revealed pneumonia-type, and bronchopneumonia, inflammatory lesions, with a predominance of mononuclear cells, necrosis of bronchial epithelium, and pulmonary parenchyma as well as hyperplasia of the bronchiolar epithelium. Prevention and control of these parasites is therefore essential for releasing the potential of sheep production.

An important factor in determining agricultural production is the availability of irrigation water in the main canal of the M’Pourie plain. This factor affects both the intensification of crops and the size of the irrigation areas. The main Senegal River canal in Rosso, Mauritania, runs across the Plaine of M’Pourie. This study aims to assess the physicochemical quality of the water used for irrigation and agriculture in the main irrigation canal on the M’Pourie plain. The measurements were made from 2021 to 2022, and the following physical and chemical parameters were monitored: pH, temperature, electrical conductivity, salt content, calcium, magnesium, sodium, and potassium; ammonium bicarbonate; chloride; nitrite; nitrate; nitrogen; sulfate; and sodium adsorption ratio (SAR). These measurements were analyzed using volumetric, spectroscopic, and spectrophotometric methods. After conducting statistical analysis and comparing the results with Moroccan quality standards for surface water utilized in irrigation, it has been discovered that the average pH value is 7.51, indicating a neutral state. However, the average nitrite and ammonium values exceed Moroccan standards at 5.16 mg.L-1 and 0.41 mg.L-1, respectively. The water’s low mineralization is attributed to its low electrical conductivity, with an average of 52.2 μS.cm-1. Based on the analysis of the Senegal River water used for irrigation in the M’Pourie plain, it has been determined that its sodium adsorption ratio and electrical conductivity classify it as belonging to class C1S1. This indicates that the water has low salinity and is excellent for irrigation, with a low risk of alkalinization.

The Devonian outcrops of the Azrou-Khenifra Basin are located in the eastern band of the Moroccan Central Massif. They are characterized by a high geodiversity since they show sedimentary, stratigraphic, paleontological, tectonic and geomorphological aspects. Those outcrops allow the understanding of the evolution and geodynamic of the area during the Devonian. This proves their relevant in term of scientific value. In addition, they also have educational and touristic interests. The objectives of this work are making the inventory and quantitative assessment as well as the mapping of nine Devonian geosites. To approach the topic, the method proposed by Brilha (2016) have been used which based on qualitative and quantitative criteria. The results show that the geosite Famennian zebra griottes limestones of Ziyar has the highest scientific value (345) while the others are characterized by scientific, educational and tourist values ranging from moderate to high. Regarding the degradation risk, the geosites have a low value. This work could be considered as the base of any geoconservation strategy and geotourism action plan in the area since it focused on the two first steps of it. This may help improve the sustainable development through the establishment of geopark consequently and enhance economical level of people living the Azrou-Khenifra area.

Résumé : Cet article analyse le récit de voyage L'usage du monde de Nicolas Bouvier à travers le prisme de ses descriptions géographiques et de ses observations ethnographiques de Tabriz dans les années 1950. Il souligne la richesse des écrits de Bouvier pour saisir avec justesse la complexité de la réalité socio-environnementale de la ville à l'époque. Il s'attarde en particulier sur les descriptions détaillées des paysages urbains et ruraux observés par le voyageur, tels que les quartiers, les marchés et la campagne environnante. Ses observations méticuleuses de la vie quotidienne et des personnes rencontrées dans les différentes parties de la région sont également analysées. L'objectif est d'explorer la valeur de ce témoignage de terrain pour la compréhension historique et anthropologique de cette société iranienne du milieu du XXe siècle. L'article vise à mettre en évidence l'approche ethnographique implicite dans les voyages de l'auteur, et la manière dont ses écrits ont permis de fixer et de documenter par écrit des aspects jusqu'alors peu documentés de la culture persane de l'époque, tant en termes de modes de vie que de paysages régionaux. Mots-clés : Tabriz, voyage, regard ethnographique, L’Usage du monde, Nicolas Bouvier.

This study explores the impact of ESG ratings on corporate performance, focusing on achieving sustainable development and corporate sustainability through innovation within the context of high-quality global economic growth. In recent years, ESG ratings have garnered significant attention in the financial sector, influencing corporate strategy and performance management. While some argue that ESG activities might detract from profitability, others highlight that firms with strong ESG performance can access low-cost capital, thereby enhancing overall performance. Using a sample of China’s A-share listed companies from 2009 to 2021, this research examines the influence and mechanisms of ESG ratings on corporate performance. The findings indicate a significant positive relationship between ESG ratings and corporate performance, which remains robust after rigorous testing. Mediation analysis reveals that ESG ratings improve corporate performance by alleviating financing constraints and enhancing corporate reputation. Furthermore, the performance-enhancing effects of ESG ratings are more pronounced in firms with robust internal controls and private enterprises. This research provides empirical evidence to support stronger ESG investment and the refinement of the ESG rating system.

Sexual violence is a criminal act which basically requires very strict law enforcement. The dimensions of sexual violence regulated in the Criminal Code are not yet able to fully regulate the forms of sexual violence that occur, where regulations related to sexual violence are regulated in articles 281-295 of the Criminal Code which have limited clarification. on rape and molestation. So, with the enactment of law number 12 of 2022 concerning criminal acts of sexual violence (UU TPKS) on May 9 2022, it becomes the new legal basis for enforcing criminal acts of sexual violence. The TPKS Law becomes a specialist Lex for regulations previously contained in the Criminal Code. The presence of the TPKS Law is a new positive law that provides clear and specific updates regarding the types of criminal acts that are classified as criminal acts of sexual violence, the rights of victims of criminal acts of sexual violence, as well as protection for victims of criminal acts of sexual violence in law enforcement. The formulation of the problem in this research is how to compare legal regulations and legal protection between the Criminal Code and Law number 12 of 2022 regarding criminal acts of sexual violence. This research uses normative juridical research methods, using secondary data sources, with primary legal materials in the form of related laws which are supported by secondary legal materials in the form of related books and journals. Based on the results of this research, the research results will be summarized as to what the position of victims is. criminal acts of sexual violence which are in the Criminal Code and Law no. 12 of 2002 which regulates different legal provisions and legal protection which in the Criminal Code is not clearly regulated regarding legal protection for victims of criminal acts of sexual violence which in law number 12 of 2002 is clearly regulated regarding the protection of victims and prevention efforts against the occurrence of criminal acts of sexual harassment.

Abstract In oxygen (O2)‐controlled cell culture, an indispensable tool in biological research, it is presumed that the incubator setpoint equals the O2 tension experienced by cells (i.e., pericellular O2). However, it is discovered that physioxic (5% O2) and hypoxic (1% O2) setpoints regularly induce anoxic (0% O2) pericellular tensions in both adherent and suspension cell cultures. Electron transport chain inhibition ablates this effect, indicating that cellular O2 consumption is the driving factor. RNA‐seq analysis revealed that primary human hepatocytes cultured in physioxia experience ischemia‐reperfusion injury due to cellular O2 consumption. A reaction‐diffusion model is developed to predict pericellular O2 tension a priori, demonstrating that the effect of cellular O2 consumption has the greatest impact in smaller volume culture vessels. By controlling pericellular O2 tension in cell culture, it is found that hypoxia vs. anoxia induce distinct breast cancer transcriptomic and translational responses, including modulation of the hypoxia‐inducible factor (HIF) pathway and metabolic reprogramming. Collectively, these findings indicate that breast cancer cells respond non‐monotonically to low O2, suggesting that anoxic cell culture is not suitable for modeling hypoxia. Furthermore, it is shown that controlling atmospheric O2 tension in cell culture incubators is insufficient to regulate O2 in cell culture, thus introducing the concept of pericellular O2‐controlled cell culture.

Flooding is a natural disaster that poses a threat to both people and the environment, necessitating proactive assessment and mitigation strategies to protect vulnerable communities and ecosystems. These measures are necessary to reduce the risk of flooding and moderate the impact of rainfall. In this study, an Analytical Hierarchy Process (AHP) was used to evaluate flood risk in a data-limited region by integrating Remote Sensing (RS) and Geographic Information System (GIS) methods. The study identified several key flood risk indicators, including topographic wetness index, elevation, slope, land cover, precipitation, distance to river, distance to road, and NDVI. The flood risk map had a score range of 8.71–30.99 %, with higher scores indicating a greater susceptibility to flooding. These scores were then used to classify the flood risk into five categories: very low, low, moderate, high, and very high. The percentages of regions falling into each category were 8.71 %, 23.52 %, 30.99 %, 22.68 %, and 14.09 % respectively. The area under the Curve (AUC) approach was used to validate the flood risk map, which showed a high degree of accuracy (0.86). The results of this study provide valuable insights for monitoring, and forecasting the probability of floods in the Dosso Region.

Access to reliable energy is crucial for development, yet many rural areas in southern Bangladesh suffer from electricity shortages, impeding essential services and hindering social and economic progress. This paper proposes integrating renewable energy-based microgrids to provide sustainable and reliable electricity, thereby improving living conditions and boosting economic growth. A detailed survey in Ruma, Bandarban, was conducted for load estimation. Simulation results for on-grid and off-grid microgrids are obtained using HOMER Pro and PVsyst software. The off-grid system includes 21.8 kW of PV, 15 kW of hydro, and 222 kWh of battery storage, while the on-grid system includes a 200 kW PV system and a 15 kW hydro turbine. The levelized cost of energy (LCOE) is 0.15 USD/kWh off-grid and 0.03 USD/kWh on-grid. The on-grid system shows economic sustainability with a 6.8-year break-even point, 13 % IRR, and 8.7 % ROI. Environmental analysis shows significant greenhouse gas reductions, with CO2 emissions decreasing from 227,778 kg/year to 199,016 kg/year. Additionally, a sensitivity analysis is conducted, which underscores the resilience of the proposed hybrid microgrid system to weather variations and cost fluctuations. This paper provides a comprehensive foundation for policymakers to consider renewable microgrids as a solution for rural electrification in southern Bangladesh, utilizing solar and hydropower resources.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic liver disease that progresses from hepatic steatosis to non-alcoholic steatohepatitis, cirrhosis, and liver cancer, posing a huge burden on human health. Existing research has confirmed that forkhead box O1 (FOXO1), as a member of the FOXO transcription factor family, is upregulated in MAFLD. Its activity is closely related to nuclear-cytoplasmic shuttling and various post-translational modifications including phosphorylation, acetylation, and methylation. FOXO1 mediates the progression of MAFLD by regulating glucose metabolism, lipid metabolism, insulin resistance, oxidative stress, hepatic fibrosis, hepatocyte autophagy, apoptosis, and immune inflammation. This article elaborates on the regulatory role of FOXO1 in MAFLD, providing a summary and new insights for the current status of drug research and targeted therapies for MAFLD.

The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections. Phytochemical-based nanoplatform is a promising emerging approach for treatment of biofilm infection. However, their therapeutic efficacy was restricted by the low drug loading capacity and lack of selectivity. Herein, we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin (ISL) loading content for effective treatment of MRSA biofilm. A dimeric ISL prodrug (ISL-G2) bearing a lipase responsive ester bond was synthesized, and then encapsulated into the amphiphilic quaternized oligochitosan. The obtained ISL-G2 loaded NPs possessed positively charged surface, which allowed cis-aconityl-d-tyrosine (CA-Tyr) binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr NPs. The NPs maintained their negatively charged surface, thus prolonging the blood circulation time. In response to low pH in the biofilms, the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive, which enhanced the accumulation and penetration of NPs in the biofilms. Sequentially, the pH-triggered release of d-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm MRSA. An in vivo study was performed on a MRSA biofilm infected wound model. This phytochemical-based system led to ∼2 log CFU (>99 %) reduction of biofilm MRSA as compared to untreated wound (P < 0.001) with negligible biotoxicity in mice. This phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.

Improving people's quality of life depends on the quality of their housing. Nowadays, countries around the world attach great importance to this issue. This article aims to analyze the discourse of social housing residents in Oran. Using the qualitative method of Post Occupancy Evaluation, the goal is to highlight the gaps between the representations that users have of their apartments, which they aspire to have, and the architectural quality of the housing they live in. The objective is to help propose responses that contribute to enhancing the architectural quality of housing.

Résumé: Cette étude vise à étudier les compétences liées à l’utilisation des TIC chez les futurs PEP algériens en formation initiale au sein du Centre de formation ouvert au niveau de la wilaya de BBA par la direction de l’éducation pour habiliter les enseignants récemment intégrés, 132 futurs enseignants de langues française ont été interrogés. L’analyse des données collectées a laissé apparaitre des niveaux de confort significatifs dans l’utilisation de la technologie, des réseaux sociaux et de l’information médiatisée. Cependant, un effort de formation considérable reste à réaliser pour que ces futurs enseignants puissent utiliser les TIC à des fins pédagogiques. Mots-clés : formation initiale ; compétences numériques ; usage technique ; usage éducatif ; TIC

Artisanal gold mining in Chami is an important lever in the country economy, owing to the benefits it brings, but it is also likely to have a negative impact on various environmental compartments. Contamination of surface and ground water by trace metals elements (ETMs) was studied in the vicinity of the Chami gold processing center. The aim of the study was to assess the water contamination by trace metals (ETMs) in the town of Chami. Nine water samples (process and boreholes) were analyzed for (Co, Cr, Cu, Ni, Pb, Zn and Hg). The analysis was carried out by the DMA 80 technique for Hg at the ONISPA laboratory in Nouakchott and the other ETM at the Kenitra geosciences laboratory by the ICP-MS technique. The results of the analyses show that the ETM concentrations are high in process water samples and low in drilling water samples. Pollution indices and coefficients of variation indicate no contamination or anthropogenic traces in the borehole samples, but high levels of Hg and Ni in the process water. These results show the accumulation of metals in significant quantities in the process waters, especially Hg, proving that the waters of the mining waste basins at the Chami processing site are becoming sources of environmental pollution by mercury, which can be released into the environment by several pathways.

Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials, provided sidedness and fluidity of the natural membrane are maintained upon coating. However, the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown. Here, we briefly review the properties of natural membranes and membrane-isolation methods, with focus on the asymmetric distribution of functional groups in natural membranes (sidedness) and the ability of molecules to float across a membrane to form functional domains (fluidity). This review concludes that hydrophilic sugar-residues of glycoproteins in the outer-leaflet of cell membranes direct the more hydrophobic inner-leaflet towards a support-surface to create a correctly-sided membrane coating, regardless of electrostatic double-layer interactions. On positively-charged support-surfaces however, strong, electrostatic double-layer attraction of negatively-charged membranes can impede homogeneous coating. In correctly-sided membrane coatings, fluidity is maintained regardless of whether the surface carries a positive or negative charge. However, membranes are frozen on positively-charged, highly-curved, small nanoparticles and localized nanoscopic structures on a support-surface. This leaves an unsupported membrane coating in between nanostructures on planar support-surfaces that is in dual-sided contact with its aqueous environment, yielding enhanced fluidity in membrane coatings on nanostructured, planar support-surfaces as compared with smooth ones.

This work demonstrates the development and effectiveness of a novel diagnostic device that uses virtual reality (VR) and micro-heating touch feedback to measure the size and temperature of lung tumors. This cutting-edge technology helps with the accurate diagnosis and localization of tumors by providing users with a warm sensation when they touch a 3D rendering of a tumor inside a VR environment. By integrating thermal feedback with immersive VR, we enhance the accuracy and intuitiveness of tumor detection, potentially contributing to better diagnostic results and enabling more efficient treatment planning. The integration of thermal feedback not only enhances the realism of the virtual interaction but also makes it easier for the user to locate tumors precisely based on temperature changes. This new method offers a more thorough and interactive way to assess the identification and localization of lung cancers, which is a significant improvement in medical diagnostics. Rapid identification and detection are crucial as they can significantly enhance survival probabilities, especially since early detection is often challenging. This paper presents the development of a novel device for lung tumor analysis, employing VR and thermal technologies to provide thermal touch feedback. At the core of this device is the innovative use of microheater-based technology, integrating new techniques for thermal sensation. Through the use of a VR interface, our microheater device was examined. Users were able to interact with 3D-rendered lung tumors and experience a heat sensation that was different from the surrounding lung tissue. The MEMS microheater demonstrated a response time of approximately 16 seconds, significantly faster than the 200 seconds required by traditional Peltier devices. The preliminary results show that our microheater device offers optimal performances in terms of response time and allows low energy consumption (range of milliwatts), compared to the Peltier actuator. The results further demonstrate that our microheater’s optimized thermal touch feedback produces precise and safe temperatures for tumor detection.