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2 results on '"Sho Uemura"'

1. Searching for millicharged particles with 1 kg of Skipper-CCDs using the NuMI beam at Fermilab

Author

Santiago Perez, Dario Rodrigues, Juan Estrada, Roni Harnik, Zhen Liu, Brenda A. Cervantes-Vergara, Juan Carlos D’Olivo, Ryan D. Plestid, Javier Tiffenberg, Tien-Tien Yu, Alexis Aguilar-Arevalo, Fabricio Alcalde-Bessia, Nicolás Avalos, Oscar Baez, Daniel Baxter, Xavier Bertou, Carla Bonifazi, Ana Botti, Gustavo Cancelo, Nuria Castelló-Mor, Alvaro E. Chavarria, Claudio R. Chavez, Fernando Chierchie, Juan Manuel De Egea, Cyrus Dreyer, Alex Drlica-Wagner, Rouven Essig, Ezequiel Estrada, Erez Etzion, Paul Grylls, Guillermo Fernandez-Moroni, Marivi Fernández-Serra, Santiago Ferreyra, Stephen Holland, Agustín Lantero Barreda, Andrew Lathrop, Ian Lawson, Ben Loer, Steffon Luoma, Edgar Marrufo Villalpando, Mauricio Martinez Montero, Kellie McGuire, Jorge Molina, Sravan Munagavalasa, Danielle Norcini, Alexander Piers, Paolo Privitera, Nathan Saffold, Richard Saldanha, Aman Singal, Radomir Smida, Miguel Sofo-Haro, Diego Stalder, Leandro Stefanazzi, Michelangelo Traina, Yu-Dai Tsai, Sho Uemura, Pedro Ventura, Rocío Vilar Cortabitarte, and Rachana Yajur

Subjects
Beyond Standard Model, Dark Matter and Double Beta Decay (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Oscura is a planned light-dark matter search experiment using Skipper-CCDs with a total active mass of 10 kg. As part of the detector development, the collaboration plans to build the Oscura Integration Test (OIT), an engineering test with 10% of the total mass. Here we discuss the early science opportunities with the OIT to search for millicharged particles (mCPs) using the NuMI beam at Fermilab. mCPs would be produced at low energies through photon-mediated processes from decays of scalar, pseudoscalar, and vector mesons, or direct Drell-Yan productions. Estimates show that the OIT would be a world-leading probe for mCPs in the ∼MeV mass range.

Published
2024
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2. Post‐operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression

Author

Yohei Masugi, Manabu Takamatsu, Mariko Tanaka, Kensuke Hara, Yosuke Inoue, Tsuyoshi Hamada, Tatsunori Suzuki, Junichi Arita, Yuki Hirose, Yoshikuni Kawaguchi, Yousuke Nakai, Atsushi Oba, Naoki Sasahira, Gaku Shimane, Tsuyoshi Takeda, Keisuke Tateishi, Sho Uemura, Mitsuhiro Fujishiro, Kiyoshi Hasegawa, Minoru Kitago, Yu Takahashi, Tetsuo Ushiku, Kengo Takeuchi, Michiie Sakamoto, and for the GTK Pancreatic Cancer Study Group in Japan

Subjects
cohort studies, oncogenes, pancreatectomy, pancreatic ductal adenocarcinoma, outcome, Pathology, RB1-214
Abstract

Abstract Alterations in KRAS, CDKN2A (p16), TP53, and SMAD4 genes have been major drivers of pancreatic carcinogenesis. The clinical course of patients with pancreatic cancer in relation to these driver alterations has not been fully characterised in large populations. We hypothesised that pancreatic carcinomas with different combinations of KRAS mutation and aberrant expression of CDKN2A, p53, and SMAD4 might show distinctive recurrence patterns and post‐operative survival outcomes. To test this hypothesis, we utilised a multi‐institutional cohort of 1,146 resected pancreatic carcinomas and assessed KRAS mutations by droplet digital polymerase chain reaction and CDKN2A, p53, and SMAD4 expression by immunohistochemistry. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for disease‐free survival (DFS) and overall survival (OS) were computed according to each molecular alteration and the number of altered genes using the Cox regression models. Multivariable competing risks regression analyses were conducted to assess the associations of the number of altered genes with specific patterns of recurrence. Loss of SMAD4 expression was associated with short DFS (multivariable HR, 1.24; 95% CI, 1.09–1.43) and OS times (multivariable HR, 1.27; 95% CI, 1.10–1.46). Compared to cases with 0–2 altered genes, cases with three and four altered genes had multivariable HRs for OS of 1.28 (95% CI, 1.09–1.51) and 1.47 (95% CI, 1.22–1.78), respectively (ptrend

Published
2023
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