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1. Autocatalytic base editing for RNA-responsive translational control

Author

Raphaël V. Gayet, Katherine Ilia, Shiva Razavi, Nathaniel D. Tippens, Makoto A. Lalwani, Kehan Zhang, Jack X. Chen, Jonathan C. Chen, Jose Vargas-Asencio, and James J. Collins

Subjects
Science
Abstract

Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. Here the authors engineer programmable RNA sensors, DART VADARs, in which ADARs autocatalytically convert target hybridization into a translational output, thus amplifying editing by endogenous ADAR via positive feedback and conferring high dynamic range and a small genetic footprint.

Published
2023
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