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Honeysuckle is a commonly used Chinese medicine for treating intestinal inflammation and other diseases. Compounds that are absorbed into the blood produce pharmacodynamic effects. However, it is still unclear which compounds in honeysuckle are absorbed into the blood. Thus, the purpose of this study was to investigate the composition and in vivo absorption of active components in honeysuckle in male Sprague-Dawley rats, and develop a controlled release hydrogel system. UPLC-LTQ-Orbitrap-MS was used to determine the active ingredients of honeysuckle in vitro and in vivo. A total of 80, out of which 42 components were found to be absorbed into the blood, which includes flavonoids, iridoids, organic acids and other compounds. FTIR analysis confirmed crosslinking between hydrogel content and drug loading, and TGA and DSC analysis indicated a high thermal stability. XRD analysis showed a decrease in crystallinity following crosslinking, and SEM revealed an irregular and hard surface. The maximum swelling and drug release were observed at pH 7.4 as compared to pH 1.2. The identified blood components can be used to determine Q-markers, while the prepared hydrogels can serve as an effective and promising carrier for the controlled release of honeysuckle extracts.

Composite action between the components of the concrete-filled steel tube (CFT) is complex and it is difficult to accurately obtain the experimental relationship between the steel tube and the core concrete of CFT columns. The triaxially stressed core concrete has been studied by hydrostatic test in past research, while little research has been focused on the mechanical behavior of steel tube of CFT columns. It is difficult to obtain the experimental constitutive relationship of the steel tube of CFT columns to reflect the real-time influence of biaxial stress state and local buckling of steel plate on the steel tube. To clarify the mechanical behavior of the steel tube of CFT columns, this paper proposed an elastoplastic analytical method considering biaxial stress state and local buckling of steel tube to obtain the stress–strain curve of the steel tube. This method applied the Hook’s law and the plasticity theory to interpret the information conveyed by the measured vertical and hoop strain histories of the steel tube. To verify its effectiveness, 11 circular concrete-filled steel tube stub columns were fabricated and tested under axial compression. Superposition results of the axial load–strain of steel tube and core concrete were compared against the experimental curves. The widely used Sakino–Sun model of the confined concrete was adopted to calculate the axial load–strain curve of the core concrete. Satisfactory agreements between the calculated and experimental results confirmed the rationality of the proposed method in tracing the constitutive relation of the biaxially stressed steel tube even after the occurrence of the local buckling. The obtained stress–strain relationship is critical for establishment of mathematical constitutive model and finite element model of steel tube.

In recent decades, the rapid development of transportation construction has increased the possibility of concrete-filled steel tubes (CFSTs) subjected to soft lateral impact. Some kinds of deviation may still exist between the soft impact process and its design prediction due to frequent safety accidents. To improve the prediction accuracy, this paper contrasted the current soft impact design with the experimental impact processes of CFSTs. The current design is represented by the method and route in Eurocode-1 Actions on structures, which belongs to the one-step type. Extra parameters were added to the one-step method to describe the inertia effect of CFST. According to the experiments and predictions, the soft impact process contains two stages, which are the initial peak stage (IPS) and the stable stage (SS). The current one-step method is consistent with SS but incorrect in IPS and its accuracy is related to the proportion of IPS and SS. An empirical formula, based on the weight of IPS, is summarized to evaluate the overall error of the one-step method in the soft impact design of CFST. This error is due to the unreasonable assumption of the inertial effect in IPS. For the demands of an accurate design in IPS, a new technical route is proposed, consisting of two steps: qualitative analysis and two-stage calculation. The qualitative analysis achieved an approximate quantitative division of IPS and SS, and provided the design loads for the two-stage calculation. The two-stage calculation supplemented the prediction of the inertia effect in IPS and independently estimated the resistances and responses of CFST in the two stages. The above qualitative analysis and two-stage calculation constituted the two-step method and its accuracy and applicability are generally better than that of the one-step design.

Axial force has a great influence on the dynamic behavior and the impact resistance of concrete-filled steel tubular (CFST) members. Based on numerical simulation and theoretical analysis, the impact response and deflection calculation method for axially loaded CFST members subjected to lateral impact are investigated in this paper. The nonlinear numerical model of an axially loaded CFST member considering the strain rate effects has been established, and the simulation accuracy has been validated by comparing with existing test results. The contrastive investigation is carried out to illustrate the influence of axial load on the variation pattern of impact force for CFST members under various structural and impact parameters, and its result indicates that the impact force-time histories for CFST members with different axial loads are mainly characterized by rectangular pulse and triangular pulse. Moreover, a simplified calculation method considering the effect of axial force is proposed based on the equivalent single degree of freedom (SDOF) method, devoted to predicting the deflection of axially loaded CFST members subjected to lateral impact. The comparisons with the numerical simulation prove that the deflection calculation method has a reasonable accuracy; thus, the proposed method can be utilized in the damage assessment and anti-impact design for CFST members subjected to lateral impact and axial load.

The energy absorption characteristic of steel tube material and concrete material is an important indicator to reflect the impact resistance of circular concrete-filled steel tubular (CFST) members. In order to efficiently simulate the material energy absorption of the steel tube and concrete under lateral impact, a nonlinear finite element model considering the material strain rate of the circular CFST member was established and validated based on the drop weight tests. Then, the energy absorption mechanism of circular CFST members subjected to lateral impact was investigated including the revelation of the energy absorption process and the determination of the energy absorption distribution for the steel tube material and concrete material, which are obtained respectively based on the comprehensive analysis of dynamic response and innovative establishment of the segmented numerical model. In addition, the influence of impact momentum on energy absorption process and the effect of impact location on energy absorption distribution are further carried out. The observations of this investigation can provide reference for the anti-impact design and damage reinforcement of circular CFST members subjected to lateral impact.

To investigate the nonlinear mechanical behavior of the wire-ring net, this paper presents a new numerical model that can collectively consider equivalence between numerical and actual wire rings. Quasi-static tests, including tensile tests on steel wires and one-ring specimens, and puncturing tests on net specimens were conducted. Based on the test results, the axial constitutive curves of steel wires were obtained. The linear correlation equations for the breaking loads of the one-ring specimens and the puncturing strength of wire-ring nets were established, both of which were related to the number of windings. The wire rings were modeled via an equivalent structure with a single winding and a circular cross section. Equivalence between the numerical and actual wire rings in terms of bending and tensile strength, total mass, contact with sliding friction, and rupture behavior were also derived and presented. In particular, the emphasis was on simulating the flattening effect, a phenomenon rarely accounted for in conventional numerical models. All dominant factors were reflected in a model with the material law by the input of material parameters. The proposed mechanical model was calibrated and verified by the data from the tests of the wire-ring net. The calibrated mechanical model is also shown to successfully simulate a full-scale test of a flexible rockfall protection barrier according to the ETAG027 standard.