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429 results on '"Rescigno A"'

1. Successful pregnancy after uterine artery embolization for uterine arterovenous malformation: a rare case report

Author: Guida M, Maffucci D, Iannuzzi G, Giordano M, Luciano G, Di Benedetto L, Cantarella R, Rescigno A, and Giugliano L
Subjects: Uterine artery embolization, fertility, uterine arteriovenous malformation, pregnancy, angiography, Gynecology and obstetrics, RG1-991
Abstract: M Guida,1 D Maffucci,1 G Iannuzzi,1 M Giordano,1 G Luciano,1 L Di Benedetto,2 R Cantarella,3 A Rescigno,3 L Giugliano1 1Università degli studi di Salerno – Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”, Salerno, Italy; 2Università degli studi di Roma “La Sapienza” – Dipartimento di Scienze Medico-Chirurgiche e di Medicina Traslazionale – Facoltà di Medicina e Psicologia Azienda Ospedaliera Sant’ Andrea, Rome, Italy; 3Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi D’Aragona, Salerno, Italy Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Ovarian reserve appears to be affected by UAE in premenopausal women. However, younger ovaries (according to biological ovarian age) exhibit a greater capacity for recovery after ovarian damage. Therefore, larger studies are needed for more conclusive results. Case report: A 28-year-old woman was admitted to our department due to life-threatening uterine bleeding, resulting in tachycardia, pallor, and sweating. The patient came with a history of two spontaneous miscarriages. After sonography and computed tomography, AVMs were identified at uterine fundus and anterior wall. Conclusion: The pathogenesis of infertility after UAE is not yet known. The peculiarity of this case was that, only few months later, the patient became pregnant and gave birth to a live fetus at 37 weeks with cesarean delivery. Keywords: uterine artery embolization, fertility, uterine arteriovenous malformation, pregnancy, angiography
Published: 2018

2. Native intra-articular knee microbiome is a matter of facts: a systematic review of clinical evidence

Author: Tommaso Bonanzinga, Pietro Conte, Giuseppe Anzillotti, Vincenzo Longobardi, Elizaveta Kon, Maria Rescigno, and Maurilio Marcacci
Subjects: intraarticular, joint, knee, microbiome, microbiota, osteoarthritis, Orthopedic surgery, RD701-811
Abstract: Purpose: Growing interest surrounds the role of human gut microbiome in the development of degenerative pathologies such as osteoarthritis (OA), but microbes have recently been detected also in other sites previously considered to be sterile. Evidence emerged suggesting that even native and osteoarthritic knee joints may host several microbial species possibly involved in the osteoarthritic degeneration. This is the first systematic review critically collecting all the available evidence on the existence and composition of knee intra-articular microbiome. Methods: A systematic research on the PubMed, Cochrane and Google Scholar databases was performed. Human clinical studies investigating the presence of intra-articular microbiome in native osteoarthritic knee joints with next-generation sequencing techniques were collected. Results: A total of eight studies were included reporting data on 255 knees. All the included studies reported evidence supporting the existence of an intra-articular microbiome in native knee joints, with detection rates varying from 5.8% to 100%. Bacteria from the Proteobacteria phylum were found to be among the most identified followed by the Actinobacteria, Firmicutes, Fusobacteria, and Bacteroideta phyla. Proteobacteria phylum were also found to be more common in osteoarthritic knees when compared to healthy joints. Furthermore, several pathways correlating those microbes to knee OA progression have been suggested and summarized in this review. Conclusions: Evidence collected in this systematic review suggests that the native knee joint, previously presumed to be a sterile environment, hosts a peculiar intra-articular microbiome with a unique composition. Furthermore, its alteration may have a link with the progression of knee osteoarthritis.
Published: 2024
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3. Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium Coccineum L. (Maltese Mushroom)

Author: Zucca Paolo, Argiolas Antonio, Nieddu Mariella, Pintus Manuela, Rosa Antonella, Sanna Fabrizio, Steri Daniela, and Rescigno Antonio
Subjects: functional food, nutraceuticals, Cynomorium coccineum, Maltese Mushroom, tarthuth, B16F10 melanoma cells, Nutrition. Foods and food supply, TX341-641
Abstract: Maltese Mushroom (Cynomorium coccineum L.) is a non-photosynthetic plant that has been used in traditional medicine for many centuries. In this paper, water extracts from the whole plant, external layer and peeled plant were studied to determine the main components responsible for its biological activities, i.e., its antimicrobial, antioxidant, and anti-tyrosinase activities; its cytotoxicity against mouse melanoma B16F10 cells; and its pro-erectile activity in adult male rats. The results of electron transfer and hydrogen transfer assays showed that the antioxidant activity was mainly due to anthocyanins in the external layer, whereas the external layer and peeled plant extracts both inhibited the microbial growth of several Gram-positive strains. In contrast, the whole plant extract had the highest anti-tyrosinase activity and exhibited pro-erectile activity when administered subcutaneously. Overall, this study elucidated which parts of Maltese Mushroom are responsible for its antimicrobial, antioxidant, and anti-tyrosinase activities and thus which extracts have potential for use in nutraceutical formulations.
Published: 2016
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4. Models of accidental dark matter with a fundamental scalar

Author: Stefano Palmisano, Francesco Rescigno, and Federica Troni
Subjects: Models for Dark Matter, Particle Nature of Dark Matter, Confinement, Grand Unification, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We consider models of accidental dark matter, namely models in which the dark matter is a composite state that is stable thanks to an accidental symmetry of the theory. The fundamental constituents are vectorlike fermions, taken to be fragments of representations of the grand unifying gauge group SU(5), as well as a scalar singlet. All the new fields are charged under a new confining gauge group, which we take to be SU(N), leading to models with complex dark matter. We analyse the models in the context of SU(5) grand unification with a non-standard approach recently proposed in the literature. The advantage of including the scalar mainly resides in the fact that it allows several undesired accidental symmetries to be broken, leading to a larger set of viable models with respect to previous literature, in which only fermions (or only scalars) were considered. Moreover these models present distinct novelties, namely dark states with non-zero baryon and lepton number and the existence of composite hybrid states of fermions and scalars. We identify phenomena that are specific to the inclusion of the scalar and discuss possibilities to test this setup.
Published: 2024
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5. Radiotherapy plus pembrolizumab for advanced urothelial carcinoma: results from the ARON-2 real-world study

Author: Mimma Rizzo, Andrey Soares, Enrique Grande, Aristotelis Bamias, Ray Manneh Kopp, Edoardo Lenci, Thomas Buttner, Samer Salah, Francesco Grillone, Icaro Thiago de Carvalho, Jose Carlos Tapia, Calogero Gucciardino, Alvaro Pinto, Alessia Mennitto, Halima Abahssain, Pasquale Rescigno, Zin Myint, Hideki Takeshita, Gian Paolo Spinelli, Lazar Popovic, Maria Giuseppa Vitale, Ondrej Fiala, Patrizia Giannatempo, Roubini Zakopoulou, Francesco Carrozza, Francesco Massari, Fernando Sabino Marques Monteiro, Maria Paola Pace, Massimo Giannini, Giandomenico Roviello, Camillo Porta, Nicola Battelli, Ravindran Kanesvaran, and Matteo Santoni
Subjects: ARON-2 study, Pembrolizumab, Radiation therapy, Stereotactic radiation therapy, Urothelial carcinoma, Real-world data, Medicine, Science
Abstract: Abstract The addition of metastasis-directed radiotherapy (MDRT) to immunotherapy in patients with advanced urothelial carcinoma (aUC) has shown promising results. We report the real-world data from the ARON-2 study (NCT05290038) on the impact of conventional (CRT) or stereotactic body radiotherapy (SBRT) on the outcome of aUC patients receiving pembrolizumab after platinum-based-chemotherapy. Medical records of 837 patients were reviewed from 60 institutions in 20 countries. Two hundred and sixty-two patients (31%) received radiotherapy (cohort A), of whom 193 (23%) received CRT and 69 (8%) received SBRT. Patients were assessed for overall survival (OS), progression-free survival (PFS), and overall response rate (ORR). Univariate and multivariate analyses were used to explore the association of variables of interest with OS and PFS. With a median follow-up of 22.7 months, the median OS was 10.2 months, 6.8 months and 16.0 months in no RT, CRT and SBRT subgroups (p = 0.005), with an 1y-OS rates of 47%, 34% and 61%, respectively (p
Published: 2024
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6. Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion

Author: Angélica Díaz-Basabe, Georgia Lattanzi, Federica Perillo, Chiara Amoroso, Alberto Baeri, Andrea Farini, Yvan Torrente, Giuseppe Penna, Maria Rescigno, Michele Ghidini, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Maurizio Vecchi, Flavio Caprioli, Federica Facciotti, and Francesco Strati
Subjects: iNKT cells, CRC, Porphyromonas gingivalis, CHI3L1, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cells. However, the impact of other bacteria associated with CRC, like Porphyromonas gingivalis, on their activation status remains unexplored. In this study, we demonstrate that mucosa-associated P. gingivalis induces a protumour phenotype in iNKT cells, subsequently influencing the composition of mononuclear-phagocyte cells within the tumor microenvironment. Mechanistically, in vivo and in vitro experiments showed that P. gingivalis reduces the cytotoxic functions of iNKT cells, hampering the iNKT cell lytic machinery through increased expression of chitinase 3-like-1 protein (CHI3L1). Neutralization of CHI3L1 effectively restores iNKT cell cytotoxic functions suggesting a therapeutic potential to reactivate iNKT cell-mediated antitumour immunity. In conclusion, our data demonstrate how P. gingivalis accelerates CRC progression by inducing the upregulation of CHI3L1 in iNKT cells, thus impairing their cytotoxic functions and promoting host tumor immune evasion.
Published: 2024
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7. Banana-shaped survival curves of metastatic renal cell carcinoma treated with first-line immune-combinations, not just a matter of 'palateau'

Author: Sara Elena Rebuzzi, Giuseppe Fornarini, Alessio Signori, Pasquale Rescigno, Giuseppe Luigi Banna, and Sebastiano Buti
Subjects: Renal cell carcinoma, immune checkpoint inhibitor, immuno-combination, immunotherapy, survival outcomes, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950
Abstract: ABSTRACTThe first-line therapy of metastatic renal cell carcinoma (mRCC) has revolutionized with the approval of immune checkpoint inhibitors (ICIs) in combination with or without tyrosine kinase inhibitors (TKIs). The choice among the many different immuno-combinations (ICI-ICI or ICI-TKI) is challenging due to the lack of predictive factors. The different shapes of the Kaplan–Meier survival curves (e.g. “banana-shaped curves”) have raised many questions on the long-term survival benefit. Here, we analyzed the factors that could have impacted the different long-term survival, including the prognostic factors distribution (IMDC score), histological factors (sarcomatoid features, PD-L1 expression), and treatment characteristics (mechanism of action, duration, discontinuation rate). This overview highlights the factors that should be considered in the first-line setting for the patients’ therapeutic choice and prognostic assessment. They are also fundamental parameters to examined for head-to-head studies and real-life, large-scale studies.
Published: 2024
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8. Baryonic thermal screening mass at NLO

Author: Leonardo Giusti, M. Laine, Davide Laudicina, Michele Pepe, and Pietro Rescigno
Subjects: Finite Temperature or Finite Density, Properties of Hadrons, Resummation, Quark-Gluon Plasma, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We determine the resummed 1-loop correction to a baryonic thermal screening mass. The calculation is carried out in the framework of a dimensionally reduced effective theory, where quarks are heavy fields due to their non-zero Matsubara frequencies. The correction due to interactions is computed at O(g 2) in the coupling constant. In order to solve a 3-body Schrödinger equation, we exploit a two-dimensional generalization of the hyperspherical harmonics method. At electroweak scale temperatures, the NLO correction represents a ∼ 4.6% increase of the free-theory value 3πT of the screening mass.
Published: 2024
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9. International multicenter real-world REGistry for patients with metastatic renAL cell carcinoma – Meet-URO 33 study (REGAL study)

Author: Sara Elena Rebuzzi, Giuseppe Fornarini, Alessio Signori, Sebastiano Buti, Giuseppe Procopio, Ugo De Giorgi, Sandro Pignata, Emanuele Naglieri, Marco Maruzzo, Giuseppe Luigi Banna, Pasquale Rescigno, Carlo Messina, Alvise Mattana, Umberto Basso, and Davide Bimbatti
Subjects: Metastatic renal cell carcinoma, Immunotherapy, Immune checkpoint inhibitor, Clinical practice, Real-world, IMDC score, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Nowadays, different therapeutic options are available for the first-line treatment of metastatic renal cell carcinoma (mRCC). Immuno-combinations are the standard first-line therapy in all mRCC patients regardless of the International Metastatic RCC Database Consortium (IMDC) risk category, even though TKI monotherapy is still a therapeutic option in selected patients. However, comparisons between the different first-line treatment strategies are lacking and few real-world data are available in this setting. For this reason, the regimen choice represents an important issue in clinical practice and the optimal treatment sequence remains unclear. Methods The REGAL study is a multicentric prospective observational study enrolling mRCC patients treated with first-line systemic therapy according to clinical practice in a real-world setting. A retrospective cohort of mRCC patients who received first-line systemic therapy from the 1st of January 2021 will also be included. The primary objective is to identify potential prognostic and predictive factors that could help guide the treatment choice; secondary objectives included the assessment of the prognostic performance of the novel prognostic Meet-URO score (IMDC score + neutrophil-to-lymphocyte ratio + bone metastases) compared with the IMDC score and the comparison between treatment strategies according to response and survival outcomes and toxicity profile. Discussion Considering the high number of therapeutic first-line strategies available for mRCC, the identification of clinical prognostic and predictive factors to candidate patients to a preferable systemic therapy is still an unmet clinical need. The Meet-URO 33 study aims to provide a large-scale real-world database on mRCC patients, to identify the clinical predictive and prognostic factors and the different performances between the ICI-based combinations according to response, survival and toxicity. Trial Registration CESC IOV 2023-78.
Published: 2024
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10. Baryonic screening masses in QCD at high temperature

Author: Leonardo Giusti, Tim Harris, Davide Laudicina, Michele Pepe, and Pietro Rescigno
Subjects: Physics, QC1-999
Abstract: We compute the baryonic screening masses of the nucleon and of its negative parity partner in thermal QCD with Nf=3 massless quarks for a wide range of temperatures, from T∼1 GeV up to ∼160 GeV. The computation is performed by Monte Carlo simulations of lattice QCD with O(a)-improved Wilson fermions by exploiting a recently proposed strategy to study non-perturbatively QCD at very high temperature. Very large spatial extensions are considered in order to have negligible finite volume effects. For each temperature we have simulated 3 or 4 values of the lattice spacing, so as to perform the continuum limit extrapolation with confidence at a few permille accuracy. The degeneracy of the positive and negative parity-state screening masses, expected from Ward identities associated to non-singlet axial transformations, provides further evidence for the restoration of chiral symmetry in the high temperature regime of QCD. In the entire range of temperatures explored, the baryonic masses deviate from the free theory result, 3πT, by 4–8%. The contribution due to the interactions is clearly visible up to the highest temperature considered, and cannot be explained by the expected leading behavior in the QCD coupling constant g over the entire range of temperatures explored.
Published: 2024
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11. Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy

Author: Christopher Bailey, Johann De Bono, Munitta Muthana, Mateus Crespo, Bora Gurel, Pasquale Rescigno, Matthew Fisher, Wayne A Phillips, Richard Allen, Harry Nunns, Janet E Brown, Haider Al-janabi, Katy Moyes, Anna Junker-Jensen, Helen B Pearson, Mary-Ellen Taplin, and Claire E Lewis
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background Androgen deprivation therapy (ADT) is a front-line treatment for prostate cancer. In some men, their tumors can become refractory leading to the development of castration-resistant prostate cancer (CRPC). This causes tumors to regrow and metastasize, despite ongoing treatment, and impacts negatively on patient survival. ADT is known to stimulate the accumulation of immunosuppressive cells like protumoral tumor-associated macrophages (TAMs), myeloid-derived suppressor cells and regulatory T cells in prostate tumors, as well as hypofunctional T cells. Protumoral TAMs have been shown to accumulate around tumor blood vessels during chemotherapy and radiotherapy in other forms of cancer, where they drive tumor relapse. Our aim was to see whether such perivascular (PV) TAMs also accumulate in ADT-treated prostate tumors prior to CRPC, and, if so, whether selectively inducing them to express a potent immunostimulant, interferon beta (IFNβ), would stimulate antitumor immunity and delay CRPC.Methods We used multiplex immunofluorescence to assess the effects of ADT on the distribution and activation status of TAMs, CD8+T cells, CD4+T cells and NK cells in mouse and/or human prostate tumors. We then used antibody-coated, lipid nanoparticles (LNPs) to selectively target a STING agonist, 2′3′-cGAMP (cGAMP), to PV TAMs in mouse prostate tumors during ADT.Results TAMs accumulated at high density around blood vessels in response to ADT and expressed markers of a protumoral phenotype including folate receptor-beta (FR-β), MRC1 (CD206), CD169 and VISTA. Additionally, higher numbers of inactive (PD-1-) CD8+T cells and reduced numbers of active (CD69+) NK cells were present in these PV tumor areas. LNPs coated with an antibody to FR-β selectively delivered cGAMP to PV TAMs in ADT-treated tumors, where they activated STING and upregulated the expression of IFNβ. This resulted in a marked increase in the density of active CD8+T cells (along with CD4+T cells and NK cells) in PV tumor areas, and significantly delayed the onset of CRPC. Antibody depletion of CD8+T cells during LNP administration demonstrated the essential role of these cells in delay in CRPC induced by LNPs.Conclusion Together, our data indicate that targeting a STING agonist to PV TAMs could be used to extend the treatment window for ADT in prostate cancer.
Published: 2024
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12. Sodium levels and immunotherapy efficacy in mRCC patients with bone metastases: sub analysis of Meet-Uro 15 study

Author: Martina Catalano, Sara Elena Rebuzzi, Marco Maruzzo, Ugo De Giorgi, Sebastiano Buti, Luca Galli, Giuseppe Fornarini, Paolo Andrea Zucali, Melanie Claps, Silvia Chiellino, Ilaria Zampiva, Stefania Pipitone, Riccardo Ricotta, Mariella Sorarù, Veronica Mollica, Marianna Tudini, Lucia Fratino, Veronica Prati, Orazio Caffo, Francesco Atzori, Franco Morelli, Giuseppe Prati, Franco Nolè, Francesca Vignani, Alessia Cavo, Marilena Di Napoli, Andrea Malgeri, Emanuele Naglieri, Alessio Signori, Giuseppe Luigi Banna, Pasquale Rescigno, Linda Cerbone, Lorenzo Antonuzzo, and Giandomenico Roviello
Subjects: renal cell carcinoma, bone metastases, immunotherapy, sodium levels, efficacy outcomes, Immunologic diseases. Allergy, RC581-607
Abstract: BackgroundImmune-checkpoint inhibitors (ICIs) have significantly improved metastatic renal cell carcinoma (mRCC) prognosis, although their efficacy in patients with bone metastases (BMs) remains poorly understood. We investigated the prognostic role of natremia in pretreated RCC patients with BMs receiving immunotherapy.Materials and methodsThis retrospective multicenter study included RCC patients with BMs receiving nivolumab as second-line therapy or beyond. Inclusion criteria involved baseline sodium levels (pre-ICI) and sodium levels after 4 weeks of nivolumab initiation (post-ICI). The population was divided into two groups based on the median value, and response rates, progression-free survival (PFS), and overall survival (OS) were assessed.ResultsAmong 120 eligible patients, those with pre-treatment sodium levels ≥140 mEq/L showed longer OS (18.7 vs. 12.0 months, p=0.04). Pre-treatment sodium levels ≥140 mEq/L were associated with better OS compared to levels
Published: 2024
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13. Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

Author: Aitor Blanco-Míguez, Sara Carloni, Cindy Cardenas, Carola Conca Dioguardi, Luca Lambroia, Giovanni Capretti, Gennaro Nappo, Alessandro Fugazza, Antonio Capogreco, Federica Armanini, Francesco Asnicar, Leonard Dubois, Davide Golzato, Paolo Manghi, Federica Pinto, Cristina Scuderi, Erminia Casari, Marco Montorsi, Andrea Anderloni, Maria Rescigno, Alessandro Repici, Alessandro Zerbi, Clelia Peano, Sabrina Tamburini, Roberto Rusconi, and Nicola Segata
Subjects: Microbial ecology, QR100-130
Abstract: Abstract Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.
Published: 2024
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14. Biliary Leak from Ducts of Luschka: Systematic Review of the Literature

Author: Antonio Vitiello, Maria Spagnuolo, Marcello Persico, Roberto Peltrini, Giovanna Berardi, Pietro Calabrese, Carlo De Werra, Carmela Rescigno, Roberto Troisi, and Vincenzo Pilone
Subjects: Luschka duct, biliary tree injury, biliary leak, cholecystectomy, Surgery, RD1-811
Abstract: Injury to the Luschka ducts (LDs), also named “subvesicular” ducts, is an under-reported cause of biliary leak following laparoscopic cholecystectomy (LC). A systematic literature search according to PRISMA guidelines was conducted in PubMed, EMBASE and Cochrane Library including all publications that described a bile leak from an LD. A total of 136 articles were retrieved from the searched databases. After the removal of duplicates and non-eligible papers, 48 studies reporting 231 leaks were included: 20 (41.6%) case reports, 2 (4.3%) comparative studies, 7 (14.9%) meeting abstracts and 19 (40.4%) retrospective cohort articles. The rate of LD leak ranges from 0.05% to 1.9%, but injury to a duct of Luschka was the second most common cause of biliary leakage in all the cohort studies (5.5% to 41%). In 21 (43.7%) cases, the leak was successfully treated with a sphincterotomy through Endoscopic Retrograde Cholangiopancreatography (ERCP) plus or minus stenting, and in 12 (25%), re-laparoscopy was necessary.
Published: 2024
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15. Instrumental activities of daily living in older patients with metastatic prostate cancer: results from the meet-URO network ADHERE prospective study

Author: Lucia Fratino, Jerry Polesel, Emilio Francesco Giunta, Marco Maruzzo, Sebastiano Buti, Mona Ali Hassan, Umberto Basso, Sara Elena Rebuzzi, Ugo De Giorgi, Marika Cinausero, Helga Lipari, Teresa Gamba, Davide Bimbatti, Arianna Dri, Paola Ermacora, Francesca Vignani, Giuseppe Fornarini, Pasquale Rescigno, and Giuseppe Luigi Banna
Subjects: Medicine, Science
Abstract: Abstract Instrumental activities of daily living (IADL) are significant health indicators closely related to executive functions and able to detect mild cognitive impairment. A decline in IADL usually precedes ADL limitation, including taking medications, and may therefore predict a cognitive decline. We aimed to investigate the association of patients’ IADL score with other clinical factors, with a particular focus on the presence of a caregiver, and the impact on adherence to androgen receptor pathway inhibitors (ARPIs) and survival outcomes within the Meet-URO 5—ADHERE study. It was a large prospective multicentre observational cohort study monitoring adherence to ARPIs in 234 metastatic castrate-resistant PC (mCRPC) patients aged ≥ 70. We observed an association between impaired IADL and lower geriatric G8 scores (p
Published: 2024
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16. Association of vaccine status, reinfections, and risk factors with Long COVID syndrome

Author: Maria Elena Romero-Ibarguengoitia, Juan Francisco Rodríguez-Torres, Arnulfo Garza-Silva, Andrea Rivera-Cavazos, Devany Paola Morales-Rodriguez, Mauricio Hurtado-Cabrera, Ricardo Kalife-Assad, Diana Villarreal-Parra, Alejandro Loose-Esparza, Juan José Gutiérrez-Arias, Yaressi Guadalupe Mata-Porras, Daniela Abigail Ojeda-Salazar, Miguel Angel Sanz-Sánchez, Arnulfo González-Cantú, Elena Azzolini, and Maria Rescigno
Subjects: Medicine, Science
Abstract: Abstract The COVID-19 pandemic had a profound global impact, characterized by a high fatality rate and the emergence of enduring consequences known as Long COVID. Our study sought to determine the prevalence of Long COVID syndrome within a population of Northeastern Mexico, correlating it with patients' comorbidities, number of COVID-19 reinfection, and vaccination status. Employing an observational cross-sectional approach, we administered a comprehensive questionnaire covering medical history, demographics, vaccination status, COVID-related symptoms, and treatment. Our participant cohort included 807 patients, with an average age of 41.5 (SD 13.6) years, and women accounting 59.3% of the cohort. The follow-up was 488 (IQR 456) days. One hundred sixty-eight subjects (20.9%) met Long COVID criteria. Long COVID-19 was more prevalent when subjects had reinfections (p = 0.02) and less frequent when they had a complete vaccination scheme (p = 0.05). Through logistic regression, we found that male gender (OR 0.5, p ≤ 0.001), blood types of AB− (OR 0.48, p = 0.003) and O− (OR 0.27, p ≤ 0.001) in comparison with A+ and two doses of vaccines (OR 0.5, p = 006) to be protective factors against Long COVID; while higher BMI (OR 1.04, p = 0.005) was a risk factor. We saw that the prevalence of Long COVID was different within vaccinated patients and specific blood types, while being female and a higher BMI were associated with an increased risk of having long-COVID.
Published: 2024
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17. Association Between Early-Life Exposure to Antibiotics and Development of Child Obesity: Population-Based Study in Italy

Author: Anna Cantarutti, Paola Rescigno, Claudia Da Borso, Joaquin Gutierrez de Rubalcava Doblas, Silvia Bressan, Elisa Barbieri, Carlo Giaquinto, and Cristina Canova
Subjects: Public aspects of medicine, RA1-1270
Abstract: BackgroundChildhood obesity is a significant public health problem representing the most severe challenge in the world. Antibiotic exposure in early life has been identified as a potential factor that can disrupt the development of the gut microbiome, which may have implications for obesity. ObjectiveThis study aims to evaluate the risk of developing obesity among children exposed to antibiotics early in life. MethodsAn Italian retrospective pediatric population-based cohort study of children born between 2004 and 2018 was adopted using the Pedianet database. Children were required to be born at term, with normal weight, and without genetic diseases or congenital anomalies. We assessed the timing of the first antibiotic prescription from birth to 6, 12, and 24 months of life and the dose-response relationship via the number of antibiotic prescriptions recorded in the first year of life (none, 1, 2, and ≥3 prescriptions). Obesity was defined as a BMI z score >3 for children aged ≤5 years and >2 for children aged >5 years, using the World Health Organization growth references. The obese incidence rate (IR) × 100 person-years and the relative 95% CI were computed using infant sex, area of residence, preschool and school age, and area deprivation index, which are the covariates of interest. A mixed-effect Cox proportional hazards model was used to estimate the hazard ratio and 95% CI for the association between antibiotic exposure in early life and child obesity between 24 months and 14 years of age, considering the family pediatricians as a random factor. Several subgroup and sensitivity analyses were performed to assess the robustness of our results. ResultsAmong 121,540 children identified, 54,698 were prescribed at least an antibiotic within the first year of life and 26,990 were classified as obese during follow-up with an incidence rate of 4.05 cases (95% CI 4.01-4.10) × 100 person-year. The risk of obesity remained consistent across different timings of antibiotic prescriptions at 6 months, 1 year, and 2 years (fully adjusted hazard ratio [aHR] 1.07, 95% CI 1.04-1.10; aHR 1.06, 95% CI 1.03-1.09; and aHR 1.07, 95% CI 1.04-1.10, respectively). Increasing the number of antibiotic exposures increases the risk of obesity significantly (P trend
Published: 2024
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18. Effectiveness of different booster vaccine combinations against SARS-CoV-2 during a six-month follow-up in Mexico and Argentina

Author: Arnulfo Garza-Silva, Diego Rivera-Salinas, Andrea Rivera-Cavazos, Iván Francisco Fernández-Chau, Andrea Belinda Cepeda-Medina, Devany Paola Morales-Rodríguez, Irene Antonieta Barco-Flores, Miguel Ángel Sanz-Sánchez, Cecilia Acciardi, Graciela Paez-Bo, Mauro M. Teixeira, Elena Azzolini, Chiara Pozzi, Maria Rescigno, and Maria Elena Romero-Ibarguengoitia
Subjects: vaccination, COVID-19, SARS-CoV-2, antibodies, booster dose, re-vaccination, Immunologic diseases. Allergy, RC581-607
Abstract: IntroductionGiven the limited number of patients in Latin America who have received a booster dose against the COVID-19, it remains crucial to comprehend the effectiveness of different vaccine combinations as boosters in real-world scenarios. This study aimed to assess the real-life efficacy of seven different vaccine schemes against COVID-19, including BNT162b2, ChAdOx1-S, Gam-COVID-Vac, and CoronaVac as primary schemes with either BNT162b2 or ChAdOx1-S as booster vaccines.MethodsIn this multicentric longitudinal observational study, participants from Mexico and Argentina were followed for infection and SARS-CoV-2 Spike 1–2 IgG antibodies during their primary vaccination course and for 185 days after the booster dose.ResultsA total of 491 patients were included, and the booster dose led to an overall increase in the humoral response for all groups. Patients who received BNT162b2 exhibited the highest antibody levels after the third dose, while those with primary Gam-COVID-Vac maintained a higher level of antibodies after six months. Infection both before vaccination and after the booster dose, and Gam-COVIDVac + BNT162b2 combination correlated with higher antibody titers.DiscussionThe sole predictor of infection in the six-month follow-up was a prior COVID-19 infection before the vaccination scheme, which decreased the risk of infection, and all booster vaccine combinations conveyed the same amount of protection.
Published: 2024
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19. Erratum to: Search for exclusive Higgs and Z boson decays to ϕγ and ργ with the ATLAS detector

Author: The ATLAS collaboration, M. Aaboud, G. Aad, B. Abbott, O. Abdinov, B. Abeloos, S. H. Abidi, O. S. AbouZeid, N. L. Abraham, H. Abramowicz, H. Abreu, R. Abreu, Y. Abulaiti, B. S. Acharya, S. Adachi, L. Adamczyk, J. Adelman, M. Adersberger, T. Adye, A. A. Affolder, Y. Afik, T. Agatonovic-Jovin, C. Agheorghiesei, J. A. Aguilar-Saavedra, S. P. Ahlen, F. Ahmadov, G. Aielli, S. Akatsuka, H. Akerstedt, T. P. A. Åkesson, E. Akilli, A. V. Akimov, G. L. Alberghi, J. Albert, P. Albicocco, M. J. Alconada Verzini, S. C. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, G. Alexander, T. Alexopoulos, M. Alhroob, B. Ali, M. Aliev, G. Alimonti, J. Alison, S. P. Alkire, B. M. M. Allbrooke, B. W. Allen, P. P. Allport, A. Aloisio, A. Alonso, F. Alonso, C. Alpigiani, A. A. Alshehri, M. I. Alstaty, B. Alvarez Gonzalez, D. Álvarez Piqueras, M. G. Alviggi, B. T. Amadio, Y. Amaral Coutinho, C. Amelung, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, G. Amundsen, C. Anastopoulos, L. S. Ancu, N. Andari, T. Andeen, C. F. Anders, J. K. Anders, K. J. Anderson, A. Andreazza, V. Andrei, S. Angelidakis, I. Angelozzi, A. Angerami, A. V. Anisenkov, N. Anjos, A. Annovi, C. Antel, M. Antonelli, A. Antonov, D. J. Antrim, F. Anulli, M. Aoki, L. Aperio Bella, G. Arabidze, Y. Arai, J. P. Araque, V. Araujo Ferraz, A. T. H. Arce, R. E. Ardell, F. A. Arduh, J-F. Arguin, S. Argyropoulos, M. Arik, A. J. Armbruster, L. J. Armitage, O. Arnaez, H. Arnold, M. Arratia, O. Arslan, A. Artamonov, G. Artoni, S. Artz, S. Asai, N. Asbah, A. Ashkenazi, L. Asquith, K. Assamagan, R. Astalos, M. Atkinson, N. B. Atlay, K. Augsten, G. Avolio, B. Axen, M. K. Ayoub, G. Azuelos, A. E. Baas, M. J. Baca, H. Bachacou, K. Bachas, M. Backes, P. Bagnaia, M. Bahmani, H. Bahrasemani, J. T. Baines, M. Bajic, O. K. Baker, P. J. Bakker, E. M. Baldin, P. Balek, F. Balli, W. K. Balunas, E. Banas, A. Bandyopadhyay, Sw. Banerjee, A. A. E. Bannoura, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, T. Barillari, M.-S. Barisits, J. T. Barkeloo, T. Barklow, N. Barlow, S. L. Barnes, B. M. Barnett, R. M. Barnett, Z. Barnovska-Blenessy, A. Baroncelli, G. Barone, A. J. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, R. Bartoldus, A. E. Barton, P. Bartos, A. Basalaev, A. Bassalat, R. L. Bates, S. J. Batista, J. R. Batley, M. Battaglia, M. Bauce, F. Bauer, H. S. Bawa, J. B. Beacham, M. D. Beattie, T. Beau, P. H. Beauchemin, P. Bechtle, H. P. Beck, H. C. Beck, K. Becker, M. Becker, C. Becot, A. J. Beddall, A. Beddall, V. A. Bednyakov, M. Bedognetti, C. P. Bee, T. A. Beermann, M. Begalli, M. Begel, J. K. Behr, A. S. Bell, G. Bella, L. Bellagamba, A. Bellerive, M. Bellomo, K. Belotskiy, O. Beltramello, N. L. Belyaev, O. Benary, D. Benchekroun, M. Bender, N. Benekos, Y. Benhammou, E. Benhar Noccioli, J. Benitez, D. P. Benjamin, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, L. J. Bergsten, J. Beringer, S. Berlendis, N. R. 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Chau, C. A. Chavez Barajas, S. Che, S. Cheatham, A. Chegwidden, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, M. A. Chelstowska, C. Chen, H. Chen, J. Chen, S. Chen, X. Chen, Y. Chen, H. C. Cheng, H. J. Cheng, A. Cheplakov, E. Cheremushkina, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, G. Chiodini, A. S. Chisholm, A. Chitan, Y. H. Chiu, M. V. Chizhov, K. Choi, A. R. Chomont, S. Chouridou, Y. S. Chow, V. Christodoulou, M. C. Chu, J. Chudoba, A. J. Chuinard, J. J. Chwastowski, L. Chytka, A. K. Ciftci, D. Cinca, V. Cindro, I. A. Cioară, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, M. Ciubancan, A. Clark, B. L. Clark, M. R. Clark, P. J. Clark, R. N. Clarke, C. Clement, Y. Coadou, M. Cobal, A. Coccaro, J. Cochran, L. Colasurdo, B. Cole, A. P. Colijn, J. Collot, T. Colombo, P. Conde Muiño, E. Coniavitis, S. H. Connell, I. A. Connelly, S. Constantinescu, G. Conti, F. Conventi, M. Cooke, A. M. Cooper-Sarkar, F. Cormier, K. J. R. Cormier, M. 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De Vasconcelos Corga, J. B. De Vivie De Regie, R. Debbe, C. Debenedetti, D. V. Dedovich, N. Dehghanian, I. Deigaard, M. Del Gaudio, J. Del Peso, D. Delgove, F. Deliot, C. M. Delitzsch, A. Dell’Acqua, L. Dell’Asta, M. Dell’Orso, M. Della Pietra, D. della Volpe, M. Delmastro, C. Delporte, P. A. Delsart, D. A. DeMarco, S. Demers, M. Demichev, A. Demilly, S. P. Denisov, D. Denysiuk, D. Derendarz, J. E. Derkaoui, F. Derue, P. Dervan, K. Desch, C. Deterre, K. Dette, M. R. Devesa, P. O. Deviveiros, A. Dewhurst, S. Dhaliwal, F. A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, W. K. Di Clemente, C. Di Donato, A. Di Girolamo, B. Di Girolamo, B. Di Micco, R. Di Nardo, K. F. Di Petrillo, A. Di Simone, R. Di Sipio, D. Di Valentino, C. Diaconu, M. Diamond, F. A. Dias, M. A. Diaz, J. Dickinson, E. B. Diehl, J. Dietrich, S. Díez Cornell, A. Dimitrievska, J. Dingfelder, P. Dita, S. Dita, F. Dittus, F. Djama, T. Djobava, J. I. Djuvsland, M. A. B. do Vale, D. Dobos, M. Dobre, D. Dodsworth, C. Doglioni, J. 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Sciandra, G. Sciolla, M. Scornajenghi, F. Scuri, F. Scutti, J. Searcy, P. Seema, S. C. Seidel, A. Seiden, J. M. Seixas, G. Sekhniaidze, K. Sekhon, S. J. Sekula, N. Semprini-Cesari, S. Senkin, C. Serfon, L. Serin, L. Serkin, M. Sessa, R. Seuster, H. Severini, T. Šfiligoj, F. Sforza, A. Sfyrla, E. Shabalina, N. W. Shaikh, L. Y. Shan, R. Shang, J. T. Shank, M. Shapiro, P. B. Shatalov, K. Shaw, S. M. Shaw, A. Shcherbakova, C. Y. Shehu, Y. Shen, N. Sherafati, A. D. Sherman, P. Sherwood, L. Shi, S. Shimizu, C. O. Shimmin, M. Shimojima, I. P. J. Shipsey, S. Shirabe, M. Shiyakova, J. Shlomi, A. Shmeleva, D. Shoaleh Saadi, M. J. Shochet, S. Shojaii, D. R. Shope, S. Shrestha, E. Shulga, M. A. Shupe, P. Sicho, A. M. Sickles, P. E. Sidebo, E. Sideras Haddad, O. Sidiropoulou, A. Sidoti, F. Siegert, Dj. Sijacki, J. Silva, S. B. Silverstein, V. Simak, L. Simic, S. Simion, E. Simioni, B. Simmons, M. Simon, P. Sinervo, N. B. Sinev, M. Sioli, G. Siragusa, I. Siral, S. Yu. Sivoklokov, J. Sjölin, M. B. Skinner, P. Skubic, M. Slater, T. Slavicek, M. Slawinska, K. Sliwa, R. Slovak, V. Smakhtin, B. H. Smart, J. Smiesko, N. Smirnov, S. Yu. Smirnov, Y. Smirnov, L. N. Smirnova, O. Smirnova, J. W. Smith, M. N. K. Smith, R. W. Smith, M. Smizanska, K. Smolek, A. A. Snesarev, I. M. Snyder, S. Snyder, R. Sobie, F. Socher, A. Soffer, A. Søgaard, D. A. Soh, G. Sokhrannyi, C. A. Solans Sanchez, M. Solar, E. Yu. Soldatov, U. Soldevila, A. A. Solodkov, A. Soloshenko, O. V. Solovyanov, V. Solovyev, P. Sommer, H. Son, A. Sopczak, D. Sosa, C. L. Sotiropoulou, S. Sottocornola, R. Soualah, A. M. Soukharev, D. South, B. C. Sowden, S. Spagnolo, M. Spalla, M. Spangenberg, F. Spanò, D. Sperlich, F. Spettel, T. M. Spieker, R. Spighi, G. Spigo, L. A. Spiller, M. Spousta, R. D. St. Denis, A. Stabile, R. Stamen, S. Stamm, E. Stanecka, R. W. Stanek, C. Stanescu, M. M. Stanitzki, B. S. Stapf, S. Stapnes, E. A. Starchenko, G. H. Stark, J. Stark, S. H. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, M. Stegler, P. Steinberg, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T. J. Stevenson, G. A. Stewart, M. C. Stockton, M. Stoebe, G. Stoicea, P. Stolte, S. Stonjek, A. R. Stradling, A. Straessner, M. E. Stramaglia, J. Strandberg, S. Strandberg, M. Strauss, P. Strizenec, R. Ströhmer, D. M. Strom, R. Stroynowski, A. Strubig, S. A. Stucci, B. Stugu, N. A. Styles, D. Su, J. Su, S. Suchek, Y. Sugaya, M. Suk, V. V. Sulin, D. M. S. Sultan, S. Sultansoy, T. Sumida, S. Sun, X. Sun, K. Suruliz, C. J. E. Suster, M. R. Sutton, S. Suzuki, M. Svatos, M. Swiatlowski, S. P. Swift, I. Sykora, T. Sykora, D. Ta, K. Tackmann, J. Taenzer, A. Taffard, R. Tafirout, E. Tahirovic, N. Taiblum, H. Takai, R. Takashima, E. H. Takasugi, K. Takeda, T. Takeshita, Y. Takubo, M. Talby, A. A. Talyshev, J. Tanaka, M. Tanaka, R. Tanaka, S. Tanaka, R. Tanioka, B. B. Tannenwald, S. Tapia Araya, S. Tapprogge, S. Tarem, G. F. Tartarelli, P. Tas, M. Tasevsky, T. Tashiro, E. Tassi, A. Tavares Delgado, Y. Tayalati, A. C. Taylor, A. J. Taylor, G. N. Taylor, P. T. E. Taylor, W. Taylor, P. Teixeira-Dias, D. Temple, H. Ten Kate, P. K. Teng, J. J. Teoh, F. Tepel, S. Terada, K. Terashi, J. Terron, S. Terzo, M. Testa, R. J. Teuscher, S. J. Thais, T. Theveneaux-Pelzer, F. Thiele, J. P. Thomas, J. Thomas-Wilsker, P. D. Thompson, A. S. Thompson, L. A. Thomsen, E. Thomson, Y. Tian, M. J. Tibbetts, R. E. Ticse Torres, V. O. Tikhomirov, Yu. A. Tikhonov, S. Timoshenko, P. Tipton, S. Tisserant, K. Todome, S. Todorova-Nova, S. Todt, J. Tojo, S. Tokár, K. Tokushuku, E. Tolley, L. Tomlinson, M. Tomoto, L. Tompkins, K. Toms, B. Tong, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, J. Toth, F. Touchard, D. R. Tovey, C. J. Treado, T. Trefzger, F. Tresoldi, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, M. F. Tripiana, W. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, M. Trottier-McDonald, M. Trovatelli, L. Truong, M. Trzebinski, A. Trzupek, K. W. Tsang, J. C-L. Tseng, P. V. Tsiareshka, N. Tsirintanis, S. Tsiskaridze, V. Tsiskaridze, E. G. Tskhadadze, I. I. Tsukerman, V. Tsulaia, S. Tsuno, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, T. T. Tulbure, A. N. Tuna, S. Turchikhin, D. Turgeman, I. Turk Cakir, R. Turra, P. M. Tuts, G. Ucchielli, I. Ueda, M. Ughetto, F. Ukegawa, G. Unal, A. Undrus, G. Unel, F. C. Ungaro, Y. Unno, K. Uno, C. Unverdorben, J. Urban, P. Urquijo, P. Urrejola, G. Usai, J. Usui, L. Vacavant, V. Vacek, B. Vachon, K. O. H. Vadla, A. Vaidya, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, L. Valéry, S. Valkar, A. Vallier, J. A. Valls Ferrer, W. Van Den Wollenberg, H. van der Graaf, P. van Gemmeren, J. Van Nieuwkoop, I. van Vulpen, M. C. van Woerden, M. Vanadia, W. Vandelli, A. Vaniachine, P. Vankov, G. Vardanyan, R. Vari, E. W. Varnes, C. Varni, T. Varol, D. Varouchas, A. Vartapetian, K. E. Varvell, J. G. Vasquez, G. A. Vasquez, F. Vazeille, D. Vazquez Furelos, T. Vazquez Schroeder, J. Veatch, V. Veeraraghavan, L. M. Veloce, F. Veloso, S. Veneziano, A. Ventura, M. Venturi, N. Venturi, A. Venturini, V. Vercesi, M. Verducci, W. Verkerke, A. T. Vermeulen, J. C. Vermeulen, M. C. Vetterli, N. Viaux Maira, O. Viazlo, I. Vichou, T. Vickey, O. E. Vickey Boeriu, G. H. A. Viehhauser, S. Viel, L. Vigani, M. Villa, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, V. B. Vinogradov, A. Vishwakarma, C. Vittori, I. Vivarelli, S. Vlachos, M. Vogel, P. Vokac, G. Volpi, H. von der Schmitt, E. von Toerne, V. Vorobel, K. Vorobev, M. Vos, R. Voss, J. H. Vossebeld, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, R. Vuillermet, I. Vukotic, P. Wagner, W. Wagner, J. Wagner-Kuhr, H. Wahlberg, S. Wahrmund, K. Wakamiya, J. Walder, R. Walker, W. Walkowiak, V. Wallangen, C. Wang, F. Wang, H. Wang, J. Wang, Q. Wang, R.-J. Wang, R. Wang, S. M. Wang, T. Wang, W. Wang, Z. Wang, C. Wanotayaroj, A. Warburton, C. P. Ward, D. R. Wardrope, A. Washbrook, P. M. Watkins, A. T. Watson, M. F. Watson, G. Watts, S. Watts, B. M. Waugh, A. F. Webb, S. Webb, M. S. Weber, S. M. Weber, S. W. Weber, S. A. Weber, J. S. Webster, A. R. Weidberg, B. Weinert, J. Weingarten, M. Weirich, C. Weiser, H. Weits, P. S. Wells, T. Wenaus, T. Wengler, S. Wenig, N. Wermes, M. D. Werner, P. Werner, M. Wessels, T. D. Weston, K. Whalen, N. L. Whallon, A. M. Wharton, A. S. White, A. White, M. J. White, R. White, D. Whiteson, B. W. Whitmore, F. J. Wickens, W. Wiedenmann, M. Wielers, C. Wiglesworth, L. A. M. Wiik-Fuchs, A. Wildauer, F. Wilk, H. G. Wilkens, H. H. Williams, S. Williams, C. Willis, S. Willocq, J. A. Wilson, I. Wingerter-Seez, E. Winkels, F. Winklmeier, O. J. Winston, B. T. Winter, M. Wittgen, M. Wobisch, A. Wolf, T. M. H. Wolf, R. Wolff, M. W. Wolter, H. Wolters, V. W. S. Wong, N. L. Woods, S. D. Worm, B. K. Wosiek, J. Wotschack, K. W. Wozniak, M. Wu, S. L. Wu, X. Wu, Y. Wu, T. R. Wyatt, B. M. Wynne, S. Xella, Z. Xi, L. Xia, D. Xu, L. Xu, T. Xu, W. Xu, B. Yabsley, S. Yacoob, D. Yamaguchi, Y. Yamaguchi, A. Yamamoto, S. Yamamoto, T. Yamanaka, F. Yamane, M. Yamatani, T. Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, Y. Yang, Z. Yang, W-M. Yao, Y. C. Yap, Y. Yasu, E. Yatsenko, K. H. Yau Wong, J. Ye, S. Ye, I. Yeletskikh, E. Yigitbasi, E. Yildirim, K. Yorita, K. Yoshihara, C. Young, C. J. S. Young, J. Yu, S. P. Y. Yuen, I. Yusuff, B. Zabinski, G. Zacharis, R. Zaidan, A. M. Zaitsev, N. Zakharchuk, J. Zalieckas, A. Zaman, S. Zambito, D. Zanzi, C. Zeitnitz, G. Zemaityte, A. Zemla, J. C. Zeng, Q. Zeng, O. Zenin, T. Ženiš, D. Zerwas, D. Zhang, F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, M. Zhang, P. Zhang, R. Zhang, X. Zhang, Y. Zhang, Z. Zhang, X. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, B. Zhou, C. Zhou, L. Zhou, M. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, A. Zibell, D. Zieminska, N. I. Zimine, C. Zimmermann, S. Zimmermann, Z. Zinonos, M. Zinser, M. Ziolkowski, L. Živković, G. Zobernig, A. Zoccoli, R. Zou, M. zur Nedden, and L. Zwalinski
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2023
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20. Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors

Author: Jacopo Chiaro, Gabriella Antignani, Sara Feola, Michaela Feodoroff, Beatriz Martins, Hanne Cojoc, Salvatore Russo, Manlio Fusciello, Firas Hamdan, Valentina Ferrari, Daniele Ciampi, Ilkka Ilonen, Jari Räsänen, Mikko Mäyränpää, Jukka Partanen, Satu Koskela, Jarno Honkanen, Jussi Halonen, Lukasz Kuryk, Maria Rescigno, Mikaela Grönholm, Rui M. Branca, Janne Lehtiö, and Vincenzo Cerullo
Subjects: Science
Abstract: Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor with a poor prognosis. As the available therapeutic options show a lack of efficacy, novel therapeutic strategies are urgently needed. Given its T-cell infiltration, we hypothesized that MPM is a suitable target for therapeutic cancer vaccination. To date, research on mesothelioma has focused on the identification of molecular signatures to better classify and characterize the disease, and little is known about therapeutic targets that engage cytotoxic (CD8+) T cells. In this study we investigate the immunopeptidomic antigen-presented landscape of MPM in both murine (AB12 cell line) and human cell lines (H28, MSTO-211H, H2452, and JL1), as well as in patients’ primary tumors. Applying state-of-the-art immuno-affinity purification methodologies, we identify MHC I-restricted peptides presented on the surface of malignant cells. We characterize in vitro the immunogenicity profile of the eluted peptides using T cells from human healthy donors and cancer patients. Furthermore, we use the most promising peptides to formulate an oncolytic virus-based precision immunotherapy (PeptiCRAd) and test its efficacy in a mouse model of mesothelioma in female mice. Overall, we demonstrate that the use of immunopeptidomic analysis in combination with oncolytic immunotherapy represents a feasible and effective strategy to tackle untreatable tumors.
Published: 2023
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21. Purification and Characterization of Proteinaceous Thermostable α-Amylase Inhibitor from Sardinian Common Bean Nieddone Cultivar (Phaseolus vulgaris L.)

Author: Stefania Peddio, Sonia Lorrai, Tinuccia Dettori, Cristina Contini, Alessandra Olianas, Barbara Manconi, Antonio Rescigno, and Paolo Zucca
Subjects: amylase, inhibitor, bean, enzyme, diabetes, phytohemagglutinin, Botany, QK1-989
Abstract: The increasing need for new treatments for obesity and diabetes has led to the development of new drugs and food supplements that could reduce carbohydrate absorption. Many starch blockers, based on common bean proteinaceous inhibitors against α-amylase (α-AI), are already present on the market. The extraction and purification of α-amylase inhibitor from a promising common bean cultivar from Sardinia (Nieddone) is described, highlighting the unique value of the Nieddone cultivar, particularly for its inhibitory activity on digestive enzymes and its complete lack of a hemagglutination effect on human red blood cells. The purification of α-AI involved two chromatographic steps (IEC and SEC) and was essential for revealing certain properties of the inhibitor. The purified inhibitor has a tetrameric structure (α2β2) and a molecular weight of approximately 42 kDa, as determined by SEC and SDS-PAGE, confirming it as a lectin-like inhibitor. The identification of the α-AI sequence was obtained by bottom-up high-resolution mass spectrometry, which allowed us to identify a unique peptide from the α chain and six unique peptides from the β chains. α-AI exhibited an optimum temperature of around 40 °C and two pH optima at 5 and 6.5, respectively. Its remarkable stability at high temperatures was measured (approximately 25% of activity retained even after 5 h at 100 °C), whereas the raw extract lost its activity entirely after just 10 min at 90 °C. Thus, the purification process significantly enhances the thermal stability of α-AI. The demonstrated effectiveness of the purified α-AI against the α-amylase enzyme in pigs, humans and insects underscores the protein’s potential for treating obesity and diabetes, as well as for managing insect pests.
Published: 2024
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22. The gut-brain axis: Correlation of choroid plexus volume and permeability with inflammatory biomarkers in Crohn's disease

Author: Cristiana Bonifacio, Giovanni Savini, Christian Reca, Federico Garoli, Riccardo Levi, Giulia Vatteroni, Luca Balzarini, Mariangela Allocca, Federica Furfaro, Arianna Dal Buono, Alessandro Armuzzi, Silvio Danese, Michela Matteoli, Maria Rescigno, Gionata Fiorino, and Letterio S. Politi
Subjects: Gut-brain axis, Choroid plexus, Plexus vascular barrier, DCE MRI, Permeability, Inflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Background: The dysregulation of the gut-brain axis in chronic inflammatory bowel diseases can cause neuro-psychological disturbances, but the underlying mechanisms are still not fully understood. The choroid plexus (CP) maintains brain homeostasis and nourishment through the secretion and clearance of cerebrospinal fluid. Recent research has demonstrated the existence of a CP vascular barrier in mice which is modulated during intestinal inflammation.This study investigates possible correlations between CP modifications and inflammatory activity in patients with Crohn's disease (CD). Methods: In this prospective study, 17 patients with CD underwent concomitant abdominal and brain 3 T MRI. The volume and permeability of CP were compared with levels of C-reactive protein (CRP), fecal calprotectin (FC), sMARIA and SES-CD scores. Results: The CP volume was negatively correlated with CRP levels (R = -0.643, p-value = 0.024) and FC (R = -0.571, p-value = 0.050). DCE metrics normalized by CP volume were positively correlated with CRP (K-trans: R = 0.587, p-value = 0.045; Vp: R = 0.706, p-value = 0.010; T1: R = 0.699, p-value = 0.011), and FC (Vp: R = 0.606, p-value = 0.037). Conclusions: Inflammatory activity in patients with CD is associated with changes in CP volume and permeability, thus supporting the hypothesis that intestinal inflammation could affect the brain through the modulation of CP vascular barrier also in humans.
Published: 2024
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23. Hyperthyroidism in non-seminomatous testicular germ cell tumors: two case reports and literature review

Author: Diletta Favero, Christoph Oing, Christoph Seidel, Pasquale Rescigno, Fabio Catalano, Malvina Cremante, Sara Elena Rebuzzi, Federico Gatto, Giovanni Rosti, Diego Ferone, Giuseppe Fornarini, and Francesco Cocchiara
Subjects: non-seminomatous testicular germ cell tumors, thyrotoxicosis, hyperthyroidism, human chorionic gonadotropin, TSH receptor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: BackgroundHuman chorionic gonadotropin (hCG)–induced hyperthyroidism is a rare paraneoplastic syndrome observed in non-seminomatous testicular germ cell tumors, due to a cross-reaction between the β-subunit of hCG with the thyroid-stimulating hormone receptor. The precise prevalence of this paraneoplastic phenomenon is unclear as, in the majority of cases, hyperthyroidism remains subclinical.Case presentationHere, we present two cases of advanced metastatic non-seminomatous testicular germ cell tumors where patients exhibited signs and symptoms of thyrotoxicosis at primary diagnosis due to excessive serum β-hCG elevation, with complete remission of symptomatology after the start of oncological treatments and no signs of relapse at the time of publication of this report. Additionally, we provide a comprehensive review of the existing literature concerning this uncommon occurrence.ConclusionDespite being a rare event, the presence of hyperthyroidism or thyrotoxicosis without clear etiology in a young man should lead to consider less frequent causes such as testicular tumors. Even if patients typically have mild symptoms that resolve after chemotherapy, in rare cases, it can be a life-threatening condition that requires prompt recognition and specific intervention.
Published: 2024
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24. Time to strategy failure and treatment beyond progression in pretreated metastatic renal cell carcinoma patients receiving nivolumab: post-hoc analysis of the Meet-URO 15 study

Author: Veronica Murianni, Alessio Signori, Sebastiano Buti, Sara Elena Rebuzzi, Davide Bimbatti, Ugo De Giorgi, Silvia Chiellino, Luca Galli, Paolo Andrea Zucali, Cristina Masini, Emanuele Naglieri, Giuseppe Procopio, Michele Milella, Lucia Fratino, Cinzia Baldessari, Riccardo Ricotta, Veronica Mollica, Mariella Sorarù, Marianna Tudini, Veronica Prati, Andrea Malgeri, Francesco Atzori, Marilena Di Napoli, Orazio Caffo, Massimiliano Spada, Franco Morelli, Giuseppe Prati, Franco Nolè, Francesca Vignani, Alessia Cavo, Helga Lipari, Giandomenico Roviello, Fabio Catalano, Alessandra Damassi, Malvina Cremante, Pasquale Rescigno, Giuseppe Fornarini, and Giuseppe Luigi Banna
Subjects: metastatic renal cell carcinoma, immunotherapy, immune checkpoint inhibitors, nivolumab, treatment beyond progression, time to strategy failure, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: BackgroundImmunotherapies exhibit peculiar cancer response patterns in contrast to chemotherapy and targeted therapy. Some patients experience disease response after initial progression or durable responses after treatment interruption. In clinical practice, immune checkpoint inhibitors may be continued after radiological progression if clinical benefit is observed. As a result, estimating progression-free survival (PFS) based on the first disease progression may not accurately reflect the actual benefit of immunotherapy.MethodsThe Meet-URO 15 study was a multicenter retrospective analysis of 571 pretreated metastatic renal cell carcinoma (mRCC) patients receiving nivolumab. Time to strategy failure (TSF) was defined as the interval from the start of immunotherapy to definitive disease progression or death. This post-hoc analysis compared TSF to PFS and assess the response and survival outcomes between patients treatated beyond progression (TBP) and non-TBP. Moreover, we evaluated the prognostic accuracy of the Meet-URO score versus the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) score based on TSF and PFS.ResultsOverall, 571 mRCC patients were included in the analysis. Median TSF was 8.6 months (95% CI: 7.0 – 10.1), while mPFS was 7.0 months (95% CI: 5.7 – 8.5). TBP patients (N = 93) had significantly longer TSF (16.3 vs 5.5 months; p < 0.001) and overall survival (OS) (34.8 vs 17.9 months; p < 0.001) but similar PFS compared to non-TBP patients. In TBP patients, a median delay of 9.6 months (range: 6.7-16.3) from the first to the definitive disease progression was observed, whereas non-TBP patients had overlapped median TSF and PFS (5.5 months). Moreover, TBP patients had a trend toward a higher overall response rate (33.3% vs 24.3%; p = 0.075) and disease control rate (61.3% vs 55.5%; p = 0.31). Finally, in the whole population the Meet-URO score outperformed the IMDC score in predicting both TSF (c-index: 0.63 vs 0.59) and PFS (0.62 vs 0.59).ConclusionWe found a 2-month difference between mTSF and mPFS in mRCC patients receiving nivolumab. However, TBP patients had better outcomes, including significantly longer TSF and OS than non-TBP patients. The Meet-URO score is a reliable predictor of TSF and PFS.
Published: 2024
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25. Impact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy

Author: Raffaele Galiero, Giuseppe Loffredo, Vittorio Simeon, Alfredo Caturano, Erica Vetrano, Giulia Medicamento, Maria Alfano, Domenico Beccia, Chiara Brin, Sara Colantuoni, Jessica Di Salvo, Raffaella Epifani, Riccardo Nevola, Raffaele Marfella, Celestino Sardu, Carmine Coppola, Ferdinando Scarano, Paolo Maggi, Cecilia Calabrese, Pellegrino De Lucia Sposito, Carolina Rescigno, Costanza Sbreglia, Fiorentino Fraganza, Roberto Parrella, Annamaria Romano, Giosuele Calabria, Benedetto Polverino, Antonio Pagano, Fabio Numis, Carolina Bologna, Mariagrazia Nunziata, Vincenzo Esposito, Nicola Coppola, Nicola Maturo, Rodolfo Nasti, Pierpaolo Di Micco, Alessandro Perrella, Luigi Elio Adinolfi, Paolo Chiodini, Marina Di Domenico, Luca Rinaldi, and Ferdinando Carlo Sasso
Subjects: Medicine, Science
Published: 2024

26. Impact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy.

Author: Raffaele Galiero, Giuseppe Loffredo, Vittorio Simeon, Alfredo Caturano, Erica Vetrano, Giulia Medicamento, Maria Alfano, Domenico Beccia, Chiara Brin, Sara Colantuoni, Jessica Di Salvo, Raffaella Epifani, Riccardo Nevola, Raffaele Marfella, Celestino Sardu, Carmine Coppola, Ferdinando Scarano, Paolo Maggi, Cecilia Calabrese, Pellegrino De Lucia Sposito, Carolina Rescigno, Costanza Sbreglia, Fiorentino Fraganza, Roberto Parrella, Annamaria Romano, Giosuele Calabria, Benedetto Polverino, Antonio Pagano, Fabio Numis, Carolina Bologna, Mariagrazia Nunziata, Vincenzo Esposito, Nicola Coppola, Nicola Maturo, Rodolfo Nasti, Pierpaolo Di Micco, Alessandro Perrella, Luigi Elio Adinolfi, Paolo Chiodini, Marina Di Domenico, Luca Rinaldi, Ferdinando Carlo Sasso, and COVOCA Study Group
Subjects: Medicine, Science
Abstract: Background & aimsSARS-Cov-2 infection manifests as a wide spectrum of clinical presentation and even now, despite the global spread of the vaccine, contagiousness is still elevated. The aim of the study was the evaluation of the impact of liver fibrosis assessed by FIB-4 and liver impairment, assessed by cytolysis indices, on intrahospital mortality in COVID-19 subjects.MethodsThis is a retrospective observational cohort study, which involved 23 COVID Hospital Units in Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. According to FIB-4 values, we subdivided the overall population in three groups (FIB-43.25), respectively group 1,2,3.ResultsAt the end of the study, 938 individuals had complete discharged/dead data. At admission, 428 patients were in group 1 (45.6%), 387 in group 2 (41.3%) and 123 in group 3 (13.1%). Among them, 758 (81%) subjects were discharged, while the remaining 180 (19%) individuals died. Multivariable Cox's regression model showed a significant association between mortality risk and severity of FIB-4 stages (group 3 vs group 1, HR 2.12, 95%CI 1.38-3.28, p3.25 (9.0%, group 3). Among dead subjects, 42 showed a FIB-43.25 (42.3%, group 3).ConclusionsFIB-4 value is significantly associated with intrahospital mortality of COVID-19 patients. During hospitalization, particularly in patients with worse outcomes, COVID-19 seems to increase the risk of acute progression of liver damage.
Published: 2024
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27. The First Quenched Galaxies: When and How?

Author: Lizhi Xie, Gabriella De Lucia, Fabio Fontanot, Michaela Hirschmann, Yannick M. Bahé, Michael L. Balogh, Adam Muzzin, Benedetta Vulcani, Devontae C. Baxter, Ben Forrest, Gillian Wilson, Gregory H. Rudnick, M. C. Cooper, and Umberto Rescigno
Subjects: Galaxy formation, Galaxy evolution, Galaxy physics, Galaxy quenching, Astrophysics, QB460-466
Abstract: Many quiescent galaxies discovered in the early Universe by JWST raise fundamental questions on when and how these galaxies became and stayed quenched. Making use of the latest version of the semianalytic model GAEA that provides good agreement with the observed quenched fractions up to z ∼ 3, we make predictions for the expected fractions of quiescent galaxies up to z ∼ 7 and analyze the main quenching mechanism. We find that in a simulated box of 685 Mpc on a side, the first quenched massive ( M _⋆ ∼ 10 ^11 M _⊙ ), Milky Way–mass, and low-mass ( M _⋆ ∼ 10 ^9.5 M _⊙ ) galaxies appear at z ∼ 4.5, z ∼ 6.2, and before z = 7, respectively. Most quenched galaxies identified at early redshifts remain quenched for more than 1 Gyr. Independently of galaxy stellar mass, the dominant quenching mechanism at high redshift is accretion disk feedback (quasar winds) from a central massive black hole, which is triggered by mergers in massive and Milky Way–mass galaxies and by disk instabilities in low-mass galaxies. Environmental stripping becomes increasingly more important at lower redshift.
Published: 2024
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28. Degradation of textile dyes using immobilized lignin peroxidase-like metalloporphines under mild experimental conditions

Author: Zucca Paolo, Rescigno Antonio, Pintus Manuela, Rinaldi Andrea C, and Sanjust Enrico
Subjects: Biomimetic, Dye, Lignin-peroxidase, Porphine, Porphyrin, Chemistry, QD1-999
Abstract: Abstract Background Synthetic dyes represent a broad and heterogeneous class of durable pollutants, that are released in large amounts by the textile industry. The ability of two immobilized metalloporphines (structurally emulating the ligninolytic peroxidases) to bleach six chosen dyes (alizarin red S, phenosafranine, xylenol orange, methylene blue, methyl green, and methyl orange) was compared to enzymatic catalysts. To achieve a green and sustainable process, very mild conditions were chosen. Results IPS/MnTSPP was the most promising biomimetic catalyst as it was able to effectively and quickly bleach all tested dyes. Biomimetic catalysis was fully characterized: maximum activity was centered at neutral pH, in the absence of any organic solvent, using hydrogen peroxide as the oxidant. The immobilized metalloporphine kept a large part of its activity during multi-cycle use; however, well-known redox mediators were not able to increase its catalytic activity. IPS/MnTSPP was also more promising for use in industrial applications than its enzymatic counterparts (lignin peroxidase, laccase, manganese peroxidase, and horseradish peroxidase). Conclusions On the whole, the conditions were very mild (standard pressure, room temperature and neutral pH, using no organic solvents, and the most environmental-friendly oxidant) and a significant bleaching and partial mineralization of the dyes was achieved in approximately 1 h. Therefore, the process was consistent with large-scale applications. The biomimetic catalyst also had more promising features than the enzymatic catalysts.
Published: 2012
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29. Measurement of the top-quark mass using a leptonic invariant mass in pp collisions at s $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector

Author: The ATLAS collaboration, G. Aad, B. Abbott, D. C. Abbott, A. Abed Abud, K. Abeling, D. K. Abhayasinghe, S. H. Abidi, O. S. AbouZeid, N. L. Abraham, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, B. Achkar, S. Adachi, L. Adam, C. Adam Bourdarios, L. Adamczyk, L. Adamek, J. Adelman, M. Adersberger, A. Adiguzel, S. Adorni, T. Adye, A. A. Affolder, Y. Afik, C. Agapopoulou, M. N. Agaras, A. Aggarwal, C. Agheorghiesei, J. A. Aguilar-Saavedra, F. Ahmadov, W. S. Ahmed, X. Ai, G. Aielli, S. Akatsuka, T. P. A. Åkesson, E. Akilli, A. V. Akimov, K. Al Khoury, G. L. Alberghi, J. Albert, M. J. Alconada Verzini, S. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, A. Alfonsi, F. Alfonsi, M. Alhroob, B. Ali, M. Aliev, G. Alimonti, C. Allaire, B. M. M. Allbrooke, B. W. Allen, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, A. A. Alshehri, E. Alunno Camelia, M. Alvarez Estevez, M. G. Alviggi, Y. Amaral Coutinho, A. Ambler, L. Ambroz, C. Amelung, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, C. S. Amrouche, F. An, C. Anastopoulos, N. Andari, T. Andeen, C. F. Anders, J. K. Anders, A. Andreazza, V. Andrei, C. R. Anelli, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, D. J. A. Antrim, F. Anulli, M. Aoki, J. A. Aparisi Pozo, L. Aperio Bella, J. P. Araque, V. Araujo Ferraz, R. Araujo Pereira, C. Arcangeletti, A. T. H. Arce, F. A. Arduh, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A. J. Armbruster, A. Armstrong, O. Arnaez, H. Arnold, Z. P. Arrubarrena Tame, G. Artoni, S. Artz, S. Asai, T. Asawatavonvanich, N. A. Asbah, E. M. Asimakopoulou, L. Asquith, J. Assahsah, K. Assamagan, R. Astalos, R. J. Atkin, M. Atkinson, N. B. Atlay, H. Atmani, K. Augsten, G. Avolio, M. K. Ayoub, G. Azuelos, H. Bachacou, K. Bachas, M. Backes, F. Backman, P. Bagnaia, H. Bahrasemani, A. J. Bailey, V. R. Bailey, J. T. Baines, C. Bakalis, O. K. Baker, P. J. Bakker, D. Bakshi Gupta, S. Balaji, E. M. Baldin, P. 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Schulte, H-C. Schultz-Coulon, M. Schumacher, B. A. Schumm, Ph. Schune, A. Schwartzman, T. A. Schwarz, Ph. Schwemling, R. Schwienhorst, A. Sciandra, G. Sciolla, M. Scodeggio, M. Scornajenghi, F. Scuri, F. Scutti, L. M. Scyboz, C. D. Sebastiani, P. Seema, S. C. Seidel, A. Seiden, B. D. Seidlitz, T. Seiss, J. M. Seixas, G. Sekhniaidze, S. J. Sekula, N. Semprini-Cesari, S. Sen, C. Serfon, L. Serin, L. Serkin, M. Sessa, H. Severini, S. Sevova, T. Šfiligoj, F. Sforza, A. Sfyrla, E. Shabalina, J. D. Shahinian, N. W. Shaikh, D. Shaked Renous, L. Y. Shan, J. T. Shank, M. Shapiro, A. Sharma, A. S. Sharma, P. B. Shatalov, K. Shaw, S. M. Shaw, M. Shehade, Y. Shen, A. D. Sherman, P. Sherwood, L. Shi, S. Shimizu, C. O. Shimmin, Y. Shimogama, M. Shimojima, I. P. J. Shipsey, S. Shirabe, M. Shiyakova, J. Shlomi, A. Shmeleva, M. J. Shochet, J. Shojaii, D. R. Shope, S. Shrestha, E. M. Shrif, E. Shulga, P. Sicho, A. M. Sickles, P. E. Sidebo, E. Sideras Haddad, O. Sidiropoulou, A. Sidoti, F. Siegert, Dj. Sijacki, M. Jr. Silva, M. V. Silva Oliveira, S. B. Silverstein, S. Simion, R. Simoniello, S. Simsek, P. Sinervo, V. Sinetckii, N. B. Sinev, S. Singh, M. Sioli, I. Siral, S. Yu. Sivoklokov, J. Sjölin, E. Skorda, P. Skubic, M. Slawinska, K. Sliwa, R. Slovak, V. Smakhtin, B. H. Smart, J. Smiesko, N. Smirnov, S. Yu. Smirnov, Y. Smirnov, L. N. Smirnova, O. Smirnova, J. W. Smith, M. Smizanska, K. Smolek, A. Smykiewicz, A. A. Snesarev, H. L. Snoek, I. M. Snyder, S. Snyder, R. Sobie, A. Soffer, A. Søgaard, F. Sohns, C. A. Solans Sanchez, E. Yu. Soldatov, U. Soldevila, A. A. Solodkov, A. Soloshenko, O. V. Solovyanov, V. Solovyev, P. Sommer, H. Son, W. Song, W. Y. Song, A. Sopczak, A. L. Sopio, F. Sopkova, C. L. Sotiropoulou, S. Sottocornola, R. Soualah, D. South, S. Spagnolo, M. Spalla, M. Spangenberg, F. Spanò, D. Sperlich, T. M. Spieker, G. Spigo, M. Spina, D. P. Spiteri, M. Spousta, A. Stabile, R. Stamen, M. Stamenkovic, E. Stanecka, B. Stanislaus, M. M. Stanitzki, M. Stankaityte, B. Stapf, E. A. Starchenko, G. H. Stark, J. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, M. Stegler, P. Steinberg, A. L. Steinhebel, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T. J. Stevenson, G. A. Stewart, M. C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Strauss, P. Strizenec, R. Ströhmer, D. M. Strom, R. Stroynowski, A. Strubig, S. A. Stucci, B. Stugu, J. Stupak, N. A. Styles, D. Su, W. Su, S. Suchek, V. V. Sulin, M. J. Sullivan, D. M. S. Sultan, S. Sultansoy, T. Sumida, S. Sun, X. Sun, K. Suruliz, C. J. E. Suster, M. R. Sutton, S. Suzuki, M. Svatos, M. Swiatlowski, S. P. Swift, T. Swirski, A. Sydorenko, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, J. Taenzer, A. Taffard, R. Tafirout, H. Takai, R. Takashima, K. Takeda, T. Takeshita, E. P. Takeva, Y. Takubo, M. Talby, A. A. Talyshev, N. M. Tamir, J. Tanaka, M. Tanaka, R. Tanaka, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G. F. Tartarelli, P. Tas, M. Tasevsky, T. Tashiro, E. Tassi, A. Tavares Delgado, Y. Tayalati, A. J. Taylor, G. N. Taylor, W. Taylor, A. S. Tee, R. Teixeira De Lima, P. Teixeira-Dias, H. Ten Kate, J. J. Teoh, S. Terada, K. Terashi, J. Terron, S. Terzo, M. Testa, R. J. Teuscher, S. J. Thais, T. Theveneaux-Pelzer, F. Thiele, D. W. Thomas, J. O. Thomas, J. P. Thomas, P. D. Thompson, L. A. Thomsen, E. Thomson, E. J. Thorpe, R. E. Ticse Torres, V. Tikhomirov, Yu. A. Tikhonov, S. Timoshenko, P. Tipton, S. Tisserant, K. Todome, S. Todorova-Nova, S. Todt, J. Tojo, S. Tokár, K. Tokushuku, E. Tolley, K. G. Tomiwa, M. Tomoto, L. Tompkins, B. Tong, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, C. Tosciri, J. Toth, R. Tovey, A. Traeet, C. J. Treado, T. Trefzger, F. Tresoldi, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, D. A. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, F. Trovato, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, J. C-L. Tseng, P. V. Tsiareshka, A. Tsirigotis, V. Tsiskaridze, E. G. Tskhadadze, M. Tsopoulou, I. I. Tsukerman, V. Tsulaia, S. Tsuno, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, T. T. Tulbure, A. N. Tuna, S. Turchikhin, D. Turgeman, I. Turk Cakir, R. J. Turner, R. Turra, P. M. Tuts, S. Tzamarias, E. Tzovara, G. Ucchielli, K. Uchida, F. Ukegawa, G. Unal, A. Undrus, G. Unel, F. C. Ungaro, Y. Unno, K. Uno, J. Urban, P. Urquijo, G. Usai, Z. Uysal, V. Vacek, B. Vachon, K. O. H. Vadla, A. Vaidya, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, L. Valéry, R. A. Vallance, A. Vallier, J. A. Valls Ferrer, T. R. Van Daalen, P. Van Gemmeren, I. Van Vulpen, M. Vanadia, W. Vandelli, M. Vandenbroucke, E. R. Vandewall, A. Vaniachine, D. Vannicola, R. Vari, E. W. Varnes, C. Varni, T. Varol, D. Varouchas, K. E. Varvell, M. E. Vasile, G. A. Vasquez, F. Vazeille, D. Vazquez Furelos, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M. J. Veen, L. M. Veloce, F. Veloso, S. Veneziano, A. Ventura, N. Venturi, A. Verbytskyi, V. Vercesi, M. Verducci, C. M. Vergel Infante, C. Vergis, W. Verkerke, A. T. Vermeulen, J. C. Vermeulen, M. C. Vetterli, N. Viaux Maira, M. Vicente Barreto Pinto, T. Vickey, O. E. Vickey Boeriu, G. H. A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, G. S. Virdee, A. Vishwakarma, C. Vittori, I. Vivarelli, M. Vogel, P. Vokac, S. E. von Buddenbrock, E. Von Toerne, V. Vorobel, K. Vorobev, M. Vos, J. H. Vossebeld, M. Vozak, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, R. Vuillermet, I. Vukotic, P. Wagner, W. Wagner, J. Wagner-Kuhr, S. Wahdan, H. Wahlberg, V. M. Walbrecht, J. Walder, R. Walker, S. D. Walker, W. Walkowiak, V. Wallangen, A. M. Wang, A. Z. Wang, C. Wang, F. Wang, H. Wang, J. Wang, P. Wang, Q. Wang, R.-J. Wang, R. Wang, S. M. Wang, W. T. Wang, W. X. Wang, Y. Wang, Z. Wang, C. Wanotayaroj, A. Warburton, C. P. Ward, D. R. Wardrope, N. Warrack, A. Washbrook, A. T. Watson, M. F. Watson, G. Watts, B. M. Waugh, A. F. Webb, S. Webb, C. Weber, M. S. Weber, S. A. Weber, S. M. Weber, A. R. Weidberg, J. Weingarten, M. Weirich, C. Weiser, P. S. Wells, T. Wenaus, T. Wengler, S. Wenig, N. Wermes, M. D. Werner, M. Wessels, T. D. Weston, K. Whalen, N. L. Whallon, A. M. Wharton, A. S. White, A. White, M. J. White, D. Whiteson, B. W. Whitmore, W. Wiedenmann, C. Wiel, M. Wielers, N. Wieseotte, C. Wiglesworth, L. A. M. Wiik-Fuchs, H. G. Wilkens, L. J. Wilkins, H. H. Williams, S. Williams, C. Willis, S. Willocq, I. Wingerter-Seez, E. Winkels, F. Winklmeier, O. J. Winston, B. T. Winter, M. Wittgen, M. Wobisch, A. Wolf, T. M. H. Wolf, R. Wolff, R. Wölker, J. Wollrath, M. W. Wolter, H. Wolters, V. W. S. Wong, N. L. Woods, S. D. Worm, B. K. Wosiek, K. W. Woźniak, K. Wraight, S. L. Wu, X. Wu, Y. Wu, T. R. Wyatt, B. M. Wynne, S. Xella, Z. Xi, X. Xiao, I. Xiotidis, D. Xu, H. Xu, L. Xu, T. Xu, W. Xu, Z. Xu, B. Yabsley, S. Yacoob, K. Yajima, D. P. Yallup, N. Yamaguchi, Y. Yamaguchi, A. Yamamoto, M. Yamatani, T. Yamazaki, Y. Yamazaki, Z. Yan, H. J. Yang, H. T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, W-M. Yao, Y. C. Yap, Y. Yasu, E. Yatsenko, H. Ye, J. Ye, S. Ye, I. Yeletskikh, M. R. Yexley, E. Yigitbasi, K. Yorita, K. Yoshihara, C. J. S. Young, C. Young, J. Yu, R. Yuan, X. Yue, M. Zaazoua, B. Zabinski, G. Zacharis, E. Zaffaroni, T. Zakareishvili, N. Zakharchuk, S. Zambito, D. Zanzi, D. R. Zaripovas, S. V. Zeißner, C. Zeitnitz, G. Zemaityte, J. C. Zeng, O. Zenin, T. Ženiš, D. Zerwas, M. Zgubič, B. Zhang, D. F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, M. Zhang, R. Zhang, S. Zhang, X. Zhang, Y. Zhang, Z. Zhang, P. Zhao, Z. Zhao, A. Zhemchugov, Z. Zheng, D. Zhong, B. Zhou, C. Zhou, M. S. Zhou, M. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, C. Zhu, H. L. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, D. Zieminska, N. I. Zimine, S. Zimmermann, Z. Zinonos, M. Ziolkowski, L. Živković, G. Zobernig, A. Zoccoli, K. Zoch, T. G. Zorbas, R. Zou, and L. Zwalinski
Subjects: Hadron-Hadron Scattering, Top Physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A measurement of the top-quark mass (m t ) in the t t ¯ $$ t\overline{t} $$ → lepton + jets channel is presented, with an experimental technique which exploits semileptonic decays of b-hadrons produced in the top-quark decay chain. The distribution of the invariant mass m ℓμ of the lepton, ℓ (with ℓ = e, μ), from the W-boson decay and the muon, μ, originating from the b-hadron decay is reconstructed, and a binned-template profile likelihood fit is performed to extract m t . The measurement is based on data corresponding to an integrated luminosity of 36.1 fb −1 of s $$ \sqrt{s} $$ = 13 TeV pp collisions provided by the Large Hadron Collider and recorded by the ATLAS detector. The measured value of the top-quark mass is m t = 174.41 ± 0.39 (stat.) ± 0.66 (syst.) ± 0.25 (recoil) GeV, where the third uncertainty arises from changing the Pythia8 parton shower gluon-recoil scheme, used in top-quark decays, to a recently developed setup.
Published: 2023
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30. Measurement of isotopic separation of argon with the prototype of the cryogenic distillation plant Aria for dark matter searches

Author: E. Aaron, P. Agnes, I. Ahmad, S. Albergo, I. F. M. Albuquerque, T. Alexander, A. K. Alton, P. Amaudruz, M. Atzori Corona, M. Ave, I. Ch. Avetisov, O. Azzolini, H. O. Back, Z. Balmforth, A. Barrado, P. Barrillon, A. Basco, G. Batignani, V. Bocci, W. M. Bonivento, B. Bottino, M. G. Boulay, J. Busto, M. Cadeddu, A. Caminata, N. Canci, A. Capra, S. Caprioli, M. Caravati, N. Cargioli, M. Carlini, P. Castello, P. Cavalcante, S. Cavuoti, S. Cebrian, J. M. Cela Ruiz, S. Chashin, A. Chepurnov, E. Chyhyrynets, L. Cifarelli, D. Cintas, M. Citterio, B. Cleveland, V. Cocco, E. Conde Vilda, L. Consiglio, S. Copello, G. Covone, M. Czubak, M. D’Aniello, S. D’Auria, M. D. Da Rocha Rolo, S. Davini, S. De Cecco, G. De Guido, D. De Gruttola, S. De Pasquale, G. De Rosa, G. Dellacasa, A. V. Derbin, A. Devoto, F. Di Capua, L. Di Noto, P. Di Stefano, G. Dolganov, F. Dordei, E. Ellingwood, T. Erjavec, S. Farenzena, M. Fernandez Diaz, G. Fiorillo, P. Franchini, D. Franco, N. Funicello, F. Gabriele, D. Gahan, C. Galbiati, G. Gallina, G. Gallus, M. Garbini, P. Garcia Abia, A. Gendotti, C. Ghiano, C. Giganti, G. K. Giovanetti, V. Goicoechea Casanueva, A. Gola, G. Grauso, G. Grilli di Cortona, A. Grobov, M. Gromov, M. Guan, M. Guerzoni, M. Gulino, C. Guo, B. R. Hackett, A. L. Hallin, A. Hamer, M. Haranczyk, T. Hessel, S. Hill, S. Horikawa, F. Hubaut, J. Hucker, T. Hugues, An. Ianni, V. Ippolito, C. Jillings, S. Jois, P. Kachru, A. A. Kemp, C. L. Kendziora, M. Kimura, I. Kochanek, K. Kondo, G. Korga, S. Koulosousas, A. Kubankin, M. Kuss, M. Kuźniak, M. La Commara, M. Lai, N. Lami, E. Le Guirriec, E. Leason, A. Leoni, L. Lidey, F. Lippi, M. Lissia, L. Luzzi, O. Lychagina, N. Maccioni, O. Macfadyen, I. N. Machulin, S. Manecki, I. Manthos, L. Mapelli, A. Margotti, S. M. Mari, C. Mariani, J. Maricic, A. Marini, M. Martínez, C. J. Martoff, M. Mascia, A. Masoni, G. Matteucci, K. Mavrokoridis, C. Maxia, A. B. McDonald, A. Messina, R. Milincic, A. Mitra, A. Moharana, S. Moioli, J. Monroe, E. Moretti, M. Morrocchi, T. Mróz, V. N. Muratova, C. Muscas, P. Musico, R. Nania, M. Nessi, K. Nikolopoulos, J. Nowak, K. Olchansky, A. Oleinik, V. Oleynikov, P. Organtini, A. Ortiz de Solórzano, L. Pagani, M. Pallavicini, L. Pandola, E. Pantic, E. Paoloni, G. Paternoster, P. A. Pegoraro, K. Pelczar, L. A. Pellegrini, C. Pellegrino, V. Pesudo, S. Piacentini, L. Pietrofaccia, N. Pino, A. Pocar, D. M. Poehlmann, S. Pordes, P. Pralavorio, D. Price, F. Ragusa, Y. Ramachers, M. Razeti, A. L. Renshaw, M. Rescigno, F. Retiere, L. P. Rignanese, C. Ripoli, A. Rivetti, A. Roberts, C. Roberts, J. Rode, G. Rogers, L. Romero, M. Rossi, A. Rubbia, M. A. Sabia, G. M. Sabiu, P. Salomone, E. Sandford, S. Sanfilippo, D. Santone, R. Santorelli, C. Savarese, E. Scapparone, G. Schillaci, F. Schukman, G. Scioli, M. Simeone, P. Skensved, M. D. Skorokhvatov, O. Smirnov, T. Smirnova, B. Smith, F. Spadoni, M. Spangenberg, R. Stefanizzi, A. Steri, V. Stornelli, S. Stracka, M. Stringer, S. Sulis, A. Sung, Y. Suvorov, A. M. Szelc, R. Tartaglia, A. Taylor, J. Taylor, S. Tedesco, G. Testera, K. Thieme, T. N. Thorpe, A. Tonazzo, A. Tricomi, E. V. Unzhakov, T. Vallivilayil John, M. Van Uffelen, T. Viant, S. Viel, R. B. Vogelaar, J. Vossebeld, M. Wada, M. B. Walczak, H. Wang, Y. Wang, S. Westerdale, L. Williams, I. Wingerter-Seez, R. Wojaczyński, Ma. M. Wojcik, T. Wright, Y. Xie, C. Yang, A. Zabihi, P. Zakhary, A. Zani, A. Zichichi, G. Zuzel, M. P. Zykova, and DarkSide-20k Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The Aria cryogenic distillation plant, located in Sardinia, Italy, is a key component of the DarkSide-20k experimental program for WIMP dark matter searches at the INFN Laboratori Nazionali del Gran Sasso, Italy. Aria is designed to purify the argon, extracted from underground wells in Colorado, USA, and used as the DarkSide-20k target material, to detector-grade quality. In this paper, we report the first measurement of argon isotopic separation by distillation with the 26 m tall Aria prototype. We discuss the measurement of the operating parameters of the column and the observation of the simultaneous separation of the three stable argon isotopes: $${}^{36}\hbox {Ar}$$ 36 Ar , $${}^{38}\textrm{Ar}$$ 38 Ar , and $${}^{40}\textrm{Ar}$$ 40 Ar . We also provide a detailed comparison of the experimental results with commercial process simulation software. This measurement of isotopic separation of argon is a significant achievement for the project, building on the success of the initial demonstration of isotopic separation of nitrogen using the same equipment in 2019.
Published: 2023
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31. Search for low mass dark matter in DarkSide-50: the bayesian network approach

Author: P. Agnes, I. F. M. Albuquerque, T. Alexander, A. K. Alton, M. Ave, H. O. Back, G. Batignani, K. Biery, V. Bocci, W. M. Bonivento, B. Bottino, S. Bussino, M. Cadeddu, M. Cadoni, F. Calaprice, A. Caminata, M. D. Campos, N. Canci, M. Caravati, N. Cargioli, M. Cariello, M. Carlini, V. Cataudella, P. Cavalcante, S. Cavuoti, S. Chashin, A. Chepurnov, C. Cicalò, G. Covone, D. D’Angelo, S. Davini, A. De Candia, S. De Cecco, G. De Filippis, G. De Rosa, A. V. Derbin, A. Devoto, M. D’Incecco, C. Dionisi, F. Dordei, M. Downing, D. D’Urso, M. Fairbairn, G. Fiorillo, D. Franco, F. Gabriele, C. Galbiati, C. Ghiano, C. Giganti, G. K. Giovanetti, A. M. Goretti, G. Grilli di Cortona, A. Grobov, M. Gromov, M. Guan, M. Gulino, B. R. Hackett, K. Herner, T. Hessel, B. Hosseini, F. Hubaut, E. V. Hungerford, An. Ianni, V. Ippolito, K. Keeter, C. L. Kendziora, M. Kimura, I. Kochanek, D. Korablev, G. Korga, A. Kubankin, M. Kuss, M. La Commara, M. Lai, X. Li, M. Lissia, G. Longo, O. Lychagina, I. N. Machulin, L. P. Mapelli, S. M. Mari, J. Maricic, A. Messina, R. Milincic, J. Monroe, M. Morrocchi, X. Mougeot, V. N. Muratova, P. Musico, A. O. Nozdrina, A. Oleinik, F. Ortica, L. Pagani, M. Pallavicini, L. Pandola, E. Pantic, E. Paoloni, K. Pelczar, N. Pelliccia, S. Piacentini, A. Pocar, D. M. Poehlmann, S. Pordes, S. S. Poudel, P. Pralavorio, D. D. Price, F. Ragusa, M. Razeti, A. Razeto, A. L. Renshaw, M. Rescigno, J. Rode, A. Romani, D. Sablone, O. Samoylov, E. Sandford, W. Sands, S. Sanfilippo, C. Savarese, B. Schlitzer, D. A. Semenov, A. Shchagin, A. Sheshukov, M. D. Skorokhvatov, O. Smirnov, A. Sotnikov, S. Stracka, Y. Suvorov, R. Tartaglia, G. Testera, A. Tonazzo, E. V. Unzhakov, A. Vishneva, R. B. Vogelaar, M. Wada, H. Wang, Y. Wang, S. Westerdale, M. M. Wojcik, X. Xiao, C. Yang, G. Zuzel, and DarkSide-50 Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We present a novel approach for the search of dark matter in the DarkSide-50 experiment, relying on Bayesian Networks. This method incorporates the detector response model into the likelihood function, explicitly maintaining the connection with the quantity of interest. No assumptions about the linearity of the problem or the shape of the probability distribution functions are required, and there is no need to morph signal and background spectra as a function of nuisance parameters. By expressing the problem in terms of Bayesian Networks, we have developed an inference algorithm based on a Markov Chain Monte Carlo to calculate the posterior probability. A clever description of the detector response model in terms of parametric matrices allows us to study the impact of systematic variations of any parameter on the final results. Our approach not only provides the desired information on the parameter of interest, but also potential constraints on the response model. Our results are consistent with recent published analyses and further refine the parameters of the detector response model.
Published: 2023
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32. The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer

Author: Beth Adamson, Nicholas Brittain, Laura Walker, Ruaridh Duncan, Sara Luzzi, Pasquale Rescigno, Graham Smith, Suzanne McGill, Richard J.S. Burchmore, Elaine Willmore, Ian Hickson, Craig N. Robson, Denisa Bogdan, Juan M. Jimenez-Vacas, Alec Paschalis, Jonathan Welti, Wei Yuan, Stuart R. McCracken, Rakesh Heer, Adam Sharp, Johann S. de Bono, and Luke Gaughan
Subjects: Endocrinology, Oncology, Medicine
Abstract: Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key therapeutic target. Although initially effective, the generation of alternatively spliced AR variants (AR-Vs) compromises efficacy of treatments. In contrast to full-length AR (AR-FL), AR-Vs constitutively activate androgenic signaling and are refractory to the current repertoire of AR-targeting therapies, which together drive disease progression. There is an unmet clinical need, therefore, to develop more durable PC therapies that can attenuate AR-V function. Exploiting the requirement of coregulatory proteins for AR-V function has the capacity to furnish tractable routes for attenuating persistent oncogenic AR signaling in advanced PC. DNA-PKcs regulates AR-FL transcriptional activity and is upregulated in both early and advanced PC. We hypothesized that DNA-PKcs is critical for AR-V function. Using a proximity biotinylation approach, we demonstrated that the DNA-PK holoenzyme is part of the AR-V7 interactome and is a key regulator of AR-V–mediated transcription and cell growth in models of advanced PC. Crucially, we provide evidence that DNA-PKcs controls global splicing and, via RBMX, regulates the maturation of AR-V and AR-FL transcripts. Ultimately, our data indicate that targeting DNA-PKcs attenuates AR-V signaling and provide evidence that DNA-PKcs blockade is an effective therapeutic option in advanced AR-V–positive patients with PC.
Published: 2023
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33. Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Author: Shobana Anpalakhan, Alessio Signori, Alessio Cortellini, Elena Verzoni, Raffaele Giusti, Giuseppe Aprile, Paola Ermacora, Annamaria Catino, Stefania Pipitone, Marilena Di Napoli, Vieri Scotti, Francesca Mazzoni, Pamela F. Guglielmini, Antonello Veccia, Marco Maruzzo, Giovanni Schinzari, Chiara Casadei, Francesco Grossi, Mimma Rizzo, Vincenzo Montesarchio, Francesco Verderame, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Caterina Accettura, Saverio Cinieri, Carlo Alberto Tondini, Andrea Camerini, Maria Chiara Banzi, Mariella Sorarù, Paolo Andrea Zucali, Francesca Vignani, Serena Ricciardi, Antonio Russo, Agnese Cosenza, Massimo Di Maio, Ugo De Giorgi, Sandro Pignata, Diana Giannarelli, Carmine Pinto, Sebastiano Buti, Giuseppe Fornarini, Sara Elena Rebuzzi, Pasquale Rescigno, Alfredo Addeo, Giuseppe L. Banna, and Melissa Bersanelli
Subjects: Immune response, Immunity, Immunology, Science
Abstract: Summary: The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of
Published: 2023
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34. Remediation of perchloroethylene contaminated groundwater using Fe0/ZnS embedded in a highly porous polymer: Experimental results on pilot-scale photoreactor and kinetic modeling analysis for industrial scale-up

Author: Wanda Navarra, Olga Sacco, Raffaella Rescigno, Christophe Daniel, Vincenzo Vaiano, Domenico Pisano, Bruno Brancato, Francesco Casertano, Mario Raiola, and Vincenzo Venditto
Subjects: Zero-valent iron (ZVI), ZnS, Syndiotactic polystyrene (sPS) aerogel, Perchloroethylene, Kinetics model, Pilot-scale photoreactor, Chemistry, QD1-999
Abstract: Perchloroethylene (PCE) is a pollutant toxic to aquatic life and suspected of being a human carcinogen. It is also recalcitrant to degradation. Therefore remediation of PCE-contaminated groundwater is currently still a challenging task. In this work, the efficiency of a UV-assisted oxidation process exploiting a photocatalyst composed of zero-valent iron supported on commercial zinc sulfide (Fe/ZnS) and incorporated in a highly porous polymer, is investigated. The experimental studies were carried out, for about six months, on a pilot-scale photoreactor operating in continuous mode at the Solofra (Campania, Italy) wastewater plant, to evaluate the effectiveness and stability of the photocatalytic system. The results show that it is possible to reach a PCE degradation in natural groundwater in the range of 85–95%%. Furthermore, a kinetic model is developed and compared with collected experimental data. The mathematical model well describes the experimental data of the photocatalytic system operating both in batch and continuous mode and therefore it can be potentially used for further scale-up of photocatalytic systems devoted to PCE degradation, allowing to estimate the catalyst weight required for total PCE removal as a function of the liquid flow rate to be treated and inlet PCE concentration.
Published: 2023
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35. Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study

Author: Alfredo Caturano, Raffaele Galiero, Erica Vetrano, Giulia Medicamento, Maria Alfano, Domenico Beccia, Chiara Brin, Sara Colantuoni, Jessica Di Salvo, Raffaella Epifani, Riccardo Nevola, Raffaele Marfella, Celestino Sardu, Carmine Coppola, Ferdinando Scarano, Paolo Maggi, Cecilia Calabrese, Pellegrino De Lucia Sposito, Carolina Rescigno, Costanza Sbreglia, Fiorentino Fraganza, Roberto Parrella, Annamaria Romano, Giosuele Calabria, Benedetto Polverino, Antonio Pagano, Fabio Giuliano Numis, Carolina Bologna, Mariagrazia Nunziata, Vincenzo Esposito, Nicola Coppola, Nicola Maturo, Rodolfo Nasti, Pierpaolo Di Micco, Alessandro Perrella, Luigi Elio Adinolfi, Marina Di Domenico, Marcellino Monda, Vincenzo Russo, Roberto Ruggiero, Giovanni Docimo, Luca Rinaldi, and Ferdinando Carlo Sasso
Subjects: acute kidney injury, octogenarian, COVID-19, in-hospital mortality, SARS-CoV-2, Science
Abstract: Background and Aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact of acute kidney injury (AKI) on the in-hospital mortality in octogenarian patients with COVID-19. Methods: This is a prospective observational cohort study, which involved 23 COVID-19 hospital units in the Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. Only patients aged ≥80 years were deemed eligible for the study. Results: 197 patients were included in the study (median age 83.0 [82.0–87.0] years; 51.5% men), with a median duration of hospitalization of 15.0 [8.0–25.0] days. From the multivariable Cox regression analysis, after the application of Šidák correction, only the respiratory rate (HR 1.09, 95% CI: 1.04 to 1.14; p < 0.001) and AKI development (HR: 3.40, 95% CI: 1.80 to 6.40; p < 0.001) were independently associated with the primary outcome. Moreover, the Kaplan–Meier analysis showed a significantly different risk of in-hospital mortality between patients with and without AKI (log-rank:
Published: 2024
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36. The prognostic value of the previous nephrectomy in pretreated metastatic renal cell carcinoma receiving immunotherapy: a sub-analysis of the Meet-URO 15 study

Author: Sara Elena Rebuzzi, Alessio Signori, Giuseppe Luigi Banna, Annalice Gandini, Giuseppe Fornarini, Alessandra Damassi, Marco Maruzzo, Ugo De Giorgi, Umberto Basso, Silvia Chiellino, Luca Galli, Paolo Andrea Zucali, Emanuela Fantinel, Emanuele Naglieri, Giuseppe Procopio, Michele Milella, Francesco Boccardo, Lucia Fratino, Stefania Pipitone, Riccardo Ricotta, Stefano Panni, Veronica Mollica, Mariella Sorarù, Matteo Santoni, Alessio Cortellini, Veronica Prati, Hector Josè Soto Parra, Daniele Santini, Francesco Atzori, Marilena Di Napoli, Orazio Caffo, Marco Messina, Franco Morelli, Giuseppe Prati, Franco Nolè, Francesca Vignani, Alessia Cavo, Giandomenico Roviello, Pasquale Rescigno, and Sebastiano Buti
Subjects: Metastatic renal cell carcinoma, Nephrectomy, Immunotherapy, Nivolumab, Prognostic, Meet URO score, Medicine
Abstract: Abstract Background Nephrectomy is considered the backbone of managing patients with localized and selected metastatic renal cell carcinoma (mRCC). The prognostic role of nephrectomy has been widely investigated with cytokines and targeted therapy, but it is still unclear in the immunotherapy era. Methods We investigated the Meet-URO-15 study dataset of 571 pretreated mRCC patients receiving nivolumab as second or further lines about the prognostic role of the previous nephrectomy (received in either the localized or metastatic setting) in the overall population and according to the Meet-URO score groups. Results Patients who underwent nephrectomy showed a significantly reduced risk of death (HR 0.44, 95% CI 0.32–0.60, p
Published: 2022
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37. Two-particle Bose–Einstein correlations in $${ pp }$$ pp collisions at $$\mathbf {\sqrt{s} = 13}$$ s = 13 TeV measured with the ATLAS detector at the LHC

Author: G. Aad, B. Abbott, D. C. Abbott, A. Abed Abud, K. Abeling, D. K. Abhayasinghe, S. H. Abidi, O. S. AbouZeid, N. L. Abraham, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, B. Achkar, S. Adachi, L. Adam, C. Adam Bourdarios, L. Adamczyk, L. Adamek, J. Adelman, M. Adersberger, A. Adiguzel, S. Adorni, T. Adye, A. A. Affolder, Y. Afik, C. Agapopoulou, M. N. Agaras, A. Aggarwal, C. Agheorghiesei, J. A. Aguilar-Saavedra, F. Ahmadov, W. S. Ahmed, X. Ai, G. Aielli, S. Akatsuka, T. P. A. Åkesson, E. Akilli, A. V. Akimov, K. Al Khoury, G. L. Alberghi, J. Albert, M. J. Alconada Verzini, S. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, D. Alexandre, T. Alexopoulos, A. Alfonsi, M. Alhroob, B. Ali, G. Alimonti, J. Alison, S. P. Alkire, C. Allaire, B. M. M. Allbrooke, B. W. Allen, P. P. Allport, A. Aloisio, A. Alonso, F. Alonso, C. Alpigiani, A. A. Alshehri, M. Alvarez Estevez, D. Álvarez Piqueras, M. G. Alviggi, Y. Amaral Coutinho, A. Ambler, L. Ambroz, C. Amelung, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, C. S. Amrouche, F. An, C. Anastopoulos, N. Andari, T. Andeen, C. F. Anders, J. K. Anders, A. Andreazza, V. Andrei, C. R. Anelli, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, M. Antonelli, D. J. A. Antrim, F. Anulli, M. Aoki, J. A. Aparisi Pozo, L. Aperio Bella, G. Arabidze, J. P. Araque, V. Araujo Ferraz, R. Araujo Pereira, C. Arcangeletti, A. T. H. Arce, F. A. Arduh, J.-F. Arguin, S. Argyropoulos, J.-H. Arling, A. J. Armbruster, A. Armstrong, O. Arnaez, H. Arnold, G. Artoni, S. Artz, S. Asai, N. A. Asbah, E. M. Asimakopoulou, L. Asquith, K. Assamagan, R. Astalos, R. J. Atkin, M. Atkinson, N. B. Atlay, H. Atmani, K. Augsten, G. Avolio, R. Avramidou, M. K. Ayoub, A. M. Azoulay, G. Azuelos, M. J. Baca, H. Bachacou, K. Bachas, M. Backes, F. Backman, P. Bagnaia, H. Bahrasemani, A. J. Bailey, V. R. Bailey, J. T. Baines, M. Bajic, C. Bakalis, O. K. Baker, P. J. Bakker, D. Bakshi Gupta, S. Balaji, E. M. Baldin, P. Balek, F. Balli, W. K. Balunas, J. Balz, E. Banas, A. Bandyopadhyay, Sw. Banerjee, A. A. E. Bannoura, L. Barak, W. M. Barbe, E. L. Barberio, D. Barberis, M. Barbero, T. Barillari, M.-S. Barisits, J. Barkeloo, T. Barklow, R. Barnea, S. L. Barnes, B. M. Barnett, R. M. Barnett, Z. Barnovska-Blenessy, A. Baroncelli, G. Barone, A. J. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, S. Barsov, R. Bartoldus, G. Bartolini, A. E. Barton, P. Bartos, A. Basalaev, A. Bassalat, R. L. Bates, S. J. Batista, S. Batlamous, J. R. Batley, B. Batool, M. Battaglia, M. Bauce, F. Bauer, K. T. Bauer, H. S. Bawa, J. B. Beacham, T. Beau, P. H. Beauchemin, F. Becherer, P. Bechtle, H. C. Beck, H. P. Beck, K. Becker, M. Becker, C. Becot, A. Beddall, A. J. Beddall, V. A. Bednyakov, M. Bedognetti, C. P. Bee, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, F. Beisiegel, A. S. Bell, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, K. Belotskiy, N. L. Belyaev, D. Benchekroun, N. Benekos, Y. Benhammou, D. P. Benjamin, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, L. J. Bergsten, J. Beringer, S. Berlendis, N. R. Bernard, G. Bernardi, C. Bernius, F. U. Bernlochner, T. Berry, P. Berta, C. Bertella, I. A. Bertram, G. J. Besjes, O. Bessidskaia Bylund, N. Besson, A. Bethani, S. Bethke, A. Betti, A. J. Bevan, J. Beyer, R. Bi, R. M. Bianchi, O. Biebel, D. Biedermann, R. Bielski, K. Bierwagen, N. V. Biesuz, M. Biglietti, T. R. V. Billoud, M. Bindi, A. Bingul, C. Bini, S. Biondi, M. Birman, T. Bisanz, J. P. Biswal, D. Biswas, A. Bitadze, C. Bittrich, K. Bjørke, K. M. Black, T. Blazek, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, G. J. Bobbink, V. S. Bobrovnikov, S. S. Bocchetta, A. Bocci, D. Bogavac, A. G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, A. S. Boldyrev, A. E. Bolz, M. Bomben, M. Bona, J. S. Bonilla, M. Boonekamp, H. M. Borecka-Bielska, A. Borisov, G. Borissov, J. Bortfeldt, D. Bortoletto, V. Bortolotto, D. Boscherini, M. Bosman, J. D. Bossio Sola, K. Bouaouda, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, S. K. Boutle, A. Boveia, J. Boyd, D. Boye, I. R. Boyko, A. J. Bozson, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J. E. Brau, W. D. Breaden Madden, K. Brendlinger, L. Brenner, R. Brenner, S. Bressler, B. Brickwedde, D. L. Briglin, D. Britton, D. Britzger, I. Brock, R. Brock, G. Brooijmans, W. K. Brooks, E. Brost, J. H. Broughton, P. A. Bruckman de Renstrom, D. Bruncko, A. Bruni, G. Bruni, L. S. Bruni, S. Bruno, B. H. Brunt, M. Bruschi, N. Bruscino, P. Bryant, L. Bryngemark, T. Buanes, Q. Buat, P. Buchholz, A. G. Buckley, I. A. Budagov, M. K. Bugge, F. Bührer, O. Bulekov, T. J. Burch, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, J. T. P. Burr, J. C. Burzynski, V. Büscher, E. Buschmann, P. J. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, P. Butti, W. Buttinger, A. Buzatu, A. R. Buzykaev, G. Cabras, S. Cabrera Urbán, D. Caforio, H. Cai, V. M. M. Cairo, O. Cakir, N. Calace, P. Calafiura, A. Calandri, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, S. Calvente Lopez, D. Calvet, S. Calvet, T. P. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, D. Cameron, R. Caminal Armadans, C. Camincher, S. Campana, M. Campanelli, A. Camplani, A. Campoverde, V. Canale, A. Canesse, M. Cano Bret, J. Cantero, T. Cao, Y. Cao, M. D. M. Capeans Garrido, M. Capua, R. Cardarelli, F. Cardillo, G. Carducci, I. Carli, T. Carli, G. Carlino, B. T. Carlson, L. Carminati, R. M. D. Carney, S. Caron, E. Carquin, S. Carrá, J. W. S. Carter, M. P. Casado, A. F. Casha, D. W. Casper, R. Castelijn, F. L. Castillo, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, A. Cattai, J. Caudron, V. Cavaliere, E. Cavallaro, V. Cavasinni, E. Celebi, L. Cerda Alberich, K. Cerny, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, A. Cervelli, S. A. Cetin, Z. Chadi, D. Chakraborty, S. K. Chan, W. S. Chan, W. Y. Chan, J. D. Chapman, B. Chargeishvili, D. G. Charlton, T. P. Charman, C. C. Chau, S. Che, A. Chegwidden, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, M. A. Chelstowska, B. Chen, C. Chen, C. H. Chen, H. Chen, J. Chen, S. Chen, S. J. Chen, X. Chen, Y. Chen, Y.-H. Chen, H. C. Cheng, H. J. Cheng, A. Cheplakov, E. Cheremushkina, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, T. J. A. Chevalérias, L. Chevalier, V. Chiarella, G. Chiarelli, G. Chiodini, A. S. Chisholm, A. Chitan, I. Chiu, Y. H. Chiu, M. V. Chizhov, K. Choi, A. R. Chomont, S. Chouridou, Y. S. Chow, M. C. Chu, X. Chu, J. Chudoba, A. J. Chuinard, J. J. Chwastowski, L. Chytka, K. M. Ciesla, D. Cinca, V. Cindro, I. A. Cioară, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, D. A. Ciubotaru, B. M. Ciungu, A. Clark, M. R. Clark, P. J. Clark, C. Clement, Y. Coadou, M. Cobal, A. Coccaro, J. Cochran, H. Cohen, A. E. C. Coimbra, L. Colasurdo, B. Cole, A. P. Colijn, J. Collot, P. Conde Muiño, E. Coniavitis, S. H. Connell, I. A. Connelly, S. Constantinescu, F. Conventi, A. M. Cooper-Sarkar, F. Cormier, K. J. R. Cormier, L. D. Corpe, M. Corradi, E. E. Corrigan, F. Corriveau, M. J. Costa, F. Costanza, D. Costanzo, G. Cowan, J. W. Cowley, J. Crane, K. Cranmer, S. J. Crawley, R. A. Creager, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, V. Croft, G. Crosetti, A. Cueto, T. Cuhadar Donszelmann, A. R. Cukierman, S. Czekierda, P. Czodrowski, M. J. Da Cunha Sargedas De Sousa, J. V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, C. Dallapiccola, M. Dam, G. D’amen, V. D’Amico, J. Damp, J. R. Dandoy, M. F. Daneri, N. P. Dang, N. S. Dann, M. Danninger, V. Dao, G. Darbo, O. Dartsi, A. Dattagupta, T. Daubney, S. D’Auria, W. Davey, C. David, T. Davidek, D. R. Davis, I. Dawson, K. De, R. De Asmundis, M. De Beurs, S. De Castro, S. De Cecco, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, D. De Pedis, A. De Salvo, U. De Sanctis, M. De Santis, A. De Santo, K. De Vasconcelos Corga, J. B. De Vivie De Regie, C. Debenedetti, D. V. Dedovich, A. M. Deiana, M. Del Gaudio, J. Del Peso, Y. Delabat Diaz, D. Delgove, F. Deliot, C. M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell’Acqua, L. Dell’Asta, M. Delmastro, C. Delporte, P. A. Delsart, D. A. DeMarco, S. Demers, M. Demichev, G. Demontigny, S. P. Denisov, D. Denysiuk, L. D’Eramo, D. Derendarz, J. E. Derkaoui, F. Derue, P. Dervan, K. Desch, C. Deterre, K. Dette, C. Deutsch, M. R. Devesa, P. O. Deviveiros, A. Dewhurst, S. Dhaliwal, F. A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, W. K. Di Clemente, C. Di Donato, A. Di Girolamo, G. Di Gregorio, B. Di Micco, R. Di Nardo, K. F. Di Petrillo, R. Di Sipio, D. Di Valentino, C. Diaconu, F. A. Dias, T. Dias Do Vale, M. A. Diaz, J. Dickinson, E. B. Diehl, J. Dietrich, S. Díez Cornell, A. Dimitrievska, W. Ding, J. Dingfelder, F. Dittus, F. Djama, T. Djobava, J. I. Djuvsland, M. A. B. Do Vale, M. Dobre, D. Dodsworth, C. Doglioni, J. Dolejsi, Z. 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Facini, R. M. Faisca Rodrigues Pereira, R. M. Fakhrutdinov, S. Falciano, P. J. Falke, S. Falke, J. Faltova, Y. Fang, G. Fanourakis, M. Fanti, M. Faraj, A. Farbin, A. Farilla, E. M. Farina, T. Farooque, S. Farrell, S. M. Farrington, P. Farthouat, F. Fassi, P. Fassnacht, D. Fassouliotis, M. Faucci Giannelli, W. J. Fawcett, L. Fayard, O. L. Fedin, W. Fedorko, M. Feickert, S. Feigl, L. Feligioni, A. Fell, C. Feng, E. J. Feng, M. Feng, M. J. Fenton, A. B. Fenyuk, J. Ferrando, A. Ferrante, A. Ferrari, P. Ferrari, R. Ferrari, D. E. Ferreira de Lima, A. Ferrer, D. Ferrere, C. Ferretti, F. Fiedler, A. Filipčič, F. Filthaut, K. D. Finelli, M. C. N. Fiolhais, L. Fiorini, F. Fischer, W. C. Fisher, I. Fleck, P. Fleischmann, R. R. M. Fletcher, T. Flick, B. M. Flierl, L. Flores, L. R. Flores Castillo, F. M. Follega, N. Fomin, J. H. Foo, G. T. Forcolin, A. Formica, F. A. Förster, A. C. Forti, A. G. Foster, M. G. Foti, D. Fournier, H. Fox, P. Francavilla, S. Francescato, M. Franchini, S. Franchino, D. 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Shope, S. Shrestha, E. M. Shrif, E. Shulga, P. Sicho, A. M. Sickles, P. E. Sidebo, E. Sideras Haddad, O. Sidiropoulou, A. Sidoti, F. Siegert, Dj. Sijacki, M.Jr. Silva, M. V. Silva Oliveira, S. B. Silverstein, S. Simion, E. Simioni, R. Simoniello, S. Simsek, P. Sinervo, V. Sinetckii, N. B. Sinev, M. Sioli, I. Siral, S. Yu. Sivoklokov, J. Sjölin, E. Skorda, P. Skubic, M. Slawinska, K. Sliwa, R. Slovak, V. Smakhtin, B. H. Smart, J. Smiesko, N. Smirnov, S. Yu. Smirnov, Y. Smirnov, L. N. Smirnova, O. Smirnova, J. W. Smith, M. Smizanska, K. Smolek, A. Smykiewicz, A. A. Snesarev, H. L. Snoek, I. M. Snyder, S. Snyder, R. Sobie, A. Soffer, A. Søgaard, F. Sohns, C. A. Solans Sanchez, E. Yu. Soldatov, U. Soldevila, A. A. Solodkov, A. Soloshenko, O. V. Solovyanov, V. Solovyev, P. Sommer, H. Son, W. Song, W. Y. Song, A. Sopczak, F. Sopkova, C. L. Sotiropoulou, S. Sottocornola, R. Soualah, A. M. Soukharev, D. South, S. Spagnolo, M. Spalla, M. Spangenberg, F. Spanò, D. Sperlich, T. M. Spieker, R. Spighi, G. Spigo, M. Spina, D. P. Spiteri, M. Spousta, A. Stabile, R. Stamen, M. Stamenkovic, E. Stanecka, B. Stanislaus, M. M. Stanitzki, M. Stankaityte, B. Stapf, E. A. Starchenko, G. H. Stark, J. Stark, S. H. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, M. Stegler, P. Steinberg, A. L. Steinhebel, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T. J. Stevenson, G. A. Stewart, M. C. Stockton, G. Stoicea, M. Stolarski, P. Stolte, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Strauss, P. Strizenec, R. Ströhmer, D. M. Strom, R. Stroynowski, A. Strubig, S. A. Stucci, B. Stugu, J. Stupak, N. A. Styles, D. Su, S. Suchek, V. V. Sulin, M. J. Sullivan, D. M. S. Sultan, S. Sultansoy, T. Sumida, S. Sun, X. Sun, K. Suruliz, C. J. E. Suster, M. R. Sutton, S. Suzuki, M. Svatos, M. Swiatlowski, S. P. Swift, T. Swirski, A. Sydorenko, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, J. Taenzer, A. Taffard, R. Tafirout, H. Takai, R. Takashima, K. Takeda, T. Takeshita, E. P. Takeva, Y. Takubo, M. Talby, A. A. Talyshev, N. M. Tamir, J. Tanaka, M. Tanaka, R. Tanaka, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, G. Tarna, G. F. Tartarelli, P. Tas, M. Tasevsky, T. Tashiro, E. Tassi, A. Tavares Delgado, Y. Tayalati, A. J. Taylor, G. N. Taylor, W. Taylor, A. S. Tee, R. Teixeira De Lima, P. Teixeira-Dias, H. Ten Kate, J. J. Teoh, S. Terada, K. Terashi, J. Terron, S. Terzo, M. Testa, R. J. Teuscher, S. J. Thais, T. Theveneaux-Pelzer, F. Thiele, D. W. Thomas, J. O. Thomas, J. P. Thomas, P. D. Thompson, L. A. Thomsen, E. Thomson, E. J. Thorpe, Y. Tian, R. E. Ticse Torres, V. Tikhomirov, Yu. A. Tikhonov, S. Timoshenko, P. Tipton, S. Tisserant, K. Todome, S. Todorova-Nova, S. Todt, J. Tojo, S. Tokár, K. Tokushuku, E. Tolley, K. G. Tomiwa, M. Tomoto, L. Tompkins, B. Tong, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, C. Tosciri, J. Toth, D. R. Tovey, A. Traeet, C. J. Treado, T. Trefzger, F. Tresoldi, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, W. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, M. Trovatelli, F. Trovato, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, J. C.-L. Tseng, P. V. Tsiareshka, A. Tsirigotis, N. Tsirintanis, V. Tsiskaridze, E. G. Tskhadadze, M. Tsopoulou, I. I. Tsukerman, V. Tsulaia, S. Tsuno, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, T. T. Tulbure, A. N. Tuna, S. Turchikhin, D. Turgeman, I. Turk Cakir, R. J. Turner, R. Turra, P. M. Tuts, S. Tzamarias, E. Tzovara, G. Ucchielli, K. Uchida, I. Ueda, M. Ughetto, F. Ukegawa, G. Unal, A. Undrus, G. Unel, F. C. Ungaro, Y. Unno, K. Uno, J. Urban, P. Urquijo, G. Usai, J. Usui, Z. Uysal, L. Vacavant, V. Vacek, B. Vachon, K. O. H. Vadla, A. Vaidya, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, L. Valéry, R. A. Vallance, A. Vallier, J. A. Valls Ferrer, T. R. Van Daalen, P. Van Gemmeren, I. Van Vulpen, M. Vanadia, W. Vandelli, A. Vaniachine, D. Vannicola, R. Vari, E. W. Varnes, C. Varni, T. Varol, D. Varouchas, K. E. Varvell, M. E. Vasile, G. A. Vasquez, J. G. Vasquez, F. Vazeille, D. Vazquez Furelos, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M. J. Veen, L. M. Veloce, F. Veloso, S. Veneziano, A. Ventura, N. Venturi, A. Verbytskyi, V. Vercesi, M. Verducci, C. M. Vergel Infante, C. Vergis, W. Verkerke, A. T. Vermeulen, J. C. Vermeulen, M. C. Vetterli, N. Viaux Maira, M. Vicente Barreto Pinto, T. Vickey, O. E. Vickey Boeriu, G. H. A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, V. B. Vinogradov, G. S. Virdee, A. Vishwakarma, C. Vittori, I. Vivarelli, M. Vogel, P. Vokac, S. E. von Buddenbrock, E. Von Toerne, V. Vorobel, K. Vorobev, M. Vos, J. H. Vossebeld, M. Vozak, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, R. Vuillermet, I. Vukotic, P. Wagner, W. Wagner, J. Wagner-Kuhr, S. Wahdan, H. Wahlberg, K. Wakamiya, V. M. Walbrecht, J. Walder, R. Walker, S. D. Walker, W. Walkowiak, V. Wallangen, A. M. Wang, C. Wang, F. Wang, H. Wang, J. Wang, P. Wang, Q. Wang, R.-J. Wang, R. Wang, S. M. Wang, W. T. Wang, W. X. Wang, Y. Wang, Z. Wang, C. Wanotayaroj, A. Warburton, C. P. Ward, D. R. Wardrope, N. Warrack, A. Washbrook, A. T. Watson, M. F. Watson, G. Watts, B. M. Waugh, A. F. Webb, S. Webb, C. Weber, M. S. Weber, S. A. Weber, S. M. Weber, A. R. Weidberg, J. Weingarten, M. Weirich, C. Weiser, P. S. Wells, T. Wenaus, T. Wengler, S. Wenig, N. Wermes, M. D. Werner, M. Wessels, T. D. Weston, K. Whalen, N. L. Whallon, A. M. Wharton, A. S. White, A. White, M. J. White, D. Whiteson, B. W. Whitmore, W. Wiedenmann, M. Wielers, N. Wieseotte, C. Wiglesworth, L. A. M. Wiik-Fuchs, F. Wilk, H. G. Wilkens, L. J. Wilkins, H. H. Williams, S. Williams, C. Willis, S. Willocq, J. A. Wilson, I. Wingerter-Seez, E. Winkels, F. Winklmeier, O. J. Winston, B. T. Winter, M. Wittgen, M. Wobisch, A. Wolf, T. M. H. Wolf, R. Wolff, R. Wölker, J. Wollrath, M. W. Wolter, H. Wolters, V. W. S. Wong, N. L. Woods, S. D. Worm, B. K. Wosiek, K. W. Woźniak, K. Wraight, S. L. Wu, X. Wu, Y. Wu, T. R. Wyatt, B. M. Wynne, S. Xella, Z. Xi, X. Xiao, D. Xu, H. Xu, L. Xu, T. Xu, W. Xu, Z. Xu, B. Yabsley, S. Yacoob, K. Yajima, D. P. Yallup, D. Yamaguchi, Y. Yamaguchi, A. Yamamoto, F. Yamane, M. Yamatani, T. Yamazaki, Y. Yamazaki, Z. Yan, H. J. Yang, H. T. Yang, S. Yang, X. Yang, Y. Yang, W.-M. Yao, Y. C. Yap, Y. Yasu, E. Yatsenko, J. Ye, S. Ye, I. Yeletskikh, M. R. Yexley, E. Yigitbasi, K. Yorita, K. Yoshihara, C. J. S. Young, C. Young, J. Yu, R. Yuan, X. Yue, S. P. Y. Yuen, B. Zabinski, G. Zacharis, E. Zaffaroni, A. M. Zaitsev, T. Zakareishvili, N. Zakharchuk, S. Zambito, D. Zanzi, D. R. Zaripovas, S. V. Zeißner, C. Zeitnitz, G. Zemaityte, J. C. Zeng, O. Zenin, T. Ženiš, D. Zerwas, M. Zgubič, D. F. Zhang, F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, M. Zhang, R. Zhang, X. Zhang, Y. Zhang, Z. Zhang, P. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, Z. Zheng, D. Zhong, B. Zhou, C. Zhou, M. S. Zhou, M. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. L. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, D. Zieminska, N. I. Zimine, S. Zimmermann, Z. Zinonos, M. Ziolkowski, L. Živković, G. Zobernig, A. Zoccoli, K. Zoch, T. G. Zorbas, R. Zou, L. Zwalinski, and ATLAS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract This paper presents studies of Bose–Einstein correlations (BEC) in proton–proton collisions at a centre-of-mass energy of 13 TeV, using data from the ATLAS detector at the CERN Large Hadron Collider. Data were collected in a special low-luminosity configuration with a minimum-bias trigger and a high-multiplicity track trigger, accumulating integrated luminosities of 151 $$\upmu $$ μ b $$^{-1}$$ - 1 and 8.4 nb $$^{-1}$$ - 1 , respectively. The BEC are measured for pairs of like-sign charged particles, each with $$|\eta | < 2.5$$ | η | < 2.5 , for two kinematic ranges: the first with particle $$p_{\mathrm {T}} > 100$$ p T > 100 MeV and the second with particle $$p_{\mathrm {T}} > 500$$ p T > 500 MeV. The BEC parameters, characterizing the source radius and particle correlation strength, are investigated as functions of charged-particle multiplicity (up to 300) and average transverse momentum of the pair (up to 1.5 GeV). The double-differential dependence on charged-particle multiplicity and average transverse momentum of the pair is also studied. The BEC radius is found to be independent of the charged-particle multiplicity for high charged-particle multiplicity (above 100), confirming a previous observation at lower energy. This saturation occurs independent of the transverse momentum of the pair.
Published: 2022
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38. SiPM cross-talk in liquid argon detectors

Author: M. G. Boulay, V. Camillo, N. Canci, S. Choudhary, L. Consiglio, A. Flammini, C. Galbiati, C. Ghiano, A. Gola, S. Horikawa, P. Kachru, I. Kochanek, K. Kondo, G. Korga, M. Kuźniak, A. Mazzi, A. Moharana, G. Nieradka, G. Paternoster, A. Razeto, D. Sablone, T. N. Thorpe, C. Türkoğlu, H. Wang, M. Rescigno, and S. Sanfilippo
Subjects: liquid argon detector, light yield, SiPM, cross-talk, correlated noises, Physics, QC1-999
Abstract: SiPM-based readouts are becoming the standard for light detection in particle detectors given their superior resolution and ease of use with respect to vacuum tube photo-multipliers. However, the contributions of noise detection such as the dark rate, cross-talk, and after-pulsing (AP) may significantly impact their performance. In this work, we present the development of highly reflective single-phase argon chambers capable of displaying light yields up to 32 photo-electrons per keV, with approximately 12 being primary photo-electrons generated by the argon scintillation, while the rest are accounted by optical cross-talk. Furthermore, the presence of compound processes results in a generalized Fano factor larger than 2 already at an over-voltage of 5 V. Finally, we present a parametrization of the optical cross-talk for the FBK NUV-HD-Cryo SiPMs at 87 K that can be extended to future detectors with tailored optical simulations.
Published: 2023
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39. Photocatalytic Activity of P-doped TiO2 Coatings Obtained at Room Temperature on Pre-treated Corona Polypropylene Films

Author: Raffaella Rescigno, Olga Sacco, Mariateresa Lettieri, Rosalba Fittipaldi, Vincenzo Vaiano, and Vincenzo Venditto
Subjects: Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract: In this work, P-doped TiO2 (P-TiO2) photocatalyst was prepared by a modified sol-gel method at room temperature and then coated on corona discharge pre-treated polypropylene films (P-TiO2/PP). The obtained photoactive P-TiO2/PP was characterized with different techniques (XRD, SEM and SSA) and the photocatalytic effect under UV and visible light was analyzed in the degradation of methylene blue (MB), used as model organic pollutant. The photocatalytic tests were carried out in a batch photoreactor irradiated by a visible lamp (nominal power of 32 W and wavelength emission > 400 nm). The experimental results showed that the coating of P-TiO2 onto PP films allowed to achieve a MB discoloration of 63% after about 240 min of visible light irradiation.
Published: 2023

40. Characterization of Non-Food Foreign Bodies Aspirated by Children: A Systematic Review of the Literature

Author: Giulia Lorenzoni, Marco Vertuani, Valeria Basso, Paola Rescigno, Honoria Ocagli, and Dario Gregori
Subjects: foreign body, aspiration, children, button batteries, Pediatrics, RJ1-570
Abstract: Background. Foreign Body Aspiration (FBA) represents a leading cause of death among unintentional injuries in children less than one year of age. This study reviewed case reports and case series reporting non-food FBA in children to characterize aspirated foreign bodies, describing the clinical presentations and the outcomes. Methods: A systematic review was conducted according to the PRISMA checklist. Case reports and case series presenting non-food FBA in children (up to 18 years) were eligible to be included. Information regarding study characteristics, child demographics, foreign body characteristics, clinical presentation, and outcome were extracted. Results: The review included 248 articles published between 1965 and 2023, corresponding to 294 cases. The male gender was the most prevalent (194 cases, 66%), and the median age was 3.5 years (Interquartile Range: 1–8 years). Button batteries were the objects most frequently reported (21 cases, 7.1%). Objects were located most often in the bronchus (102 cases, 35%). The most common symptom was cough (181 cases, 62%), followed by respiratory distress (160 cases, 54%) and wheezing/stridor (127 cases, 43%). Conclusions: The present systematic review may have relevant public health implications, since characterizing objects that cause foreign body injuries is essential to reduce the burden of this phenomenon.
Published: 2023
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41. A ‘Multiomic’ Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in Coronavirus Disease 2019

Author: Chiara Pozzi, Riccardo Levi, Daniele Braga, Francesco Carli, Abbass Darwich, Ilaria Spadoni, Bianca Oresta, Carola Conca Dioguardi, Clelia Peano, Leonardo Ubaldi, Giovanni Angelotti, Barbara Bottazzi, Cecilia Garlanda, Antonio Desai, Antonio Voza, Elena Azzolini, Maurizio Cecconi, Alberto Mantovani, Giuseppe Penna, Riccardo Barbieri, Letterio S. Politi, Maria Rescigno, Aghemo Alessio, Anfray Clement, Badalamenti Salvatore, Belgiovine Cristina, Bertocchi Alice, Bombace Sara, Brescia Paola, Calcaterra Francesca, Calvi Michela, Cancellara Assunta, Capucetti Arianna, Carenza Claudia, Carloni Sara, Carnevale Silvia, Cazzetta Valentina, Cecconi Maurizio, Ciccarelli Michele, Coianiz Nicolò, Darwich Abbass, Lleo de Nalda Ana, De Paoli Federica, Di Donato Rachele, Digifico Elisabeth, Durante Barbara, FARINA Floriana Maria, Ferrari Valentina, Fornasa Giulia, Franzese Sara, Gil Gomez Antonio, Giugliano Silvia, Gomes Ana Rita, Lizier Michela, Lo Cascio Antonino, Melacarne Alessia, Mozzarelli Alessandro, My Ilaria, Oresta Bianca, Pasqualini Fabio, Pastò Anna, Pelamatti Erica, Perucchini Chiara, Pozzi Chiara, Rimoldi Valeria, Rimoldi Monica, Scarpa Alice, Selmi Carlo, Silvestri Alessandra, Sironi Marina, Spadoni Ilaria, Spano' Salvatore, Spata Gianmarco, Supino Domenico, Tentorio Paolo, Ummarino Aldo, Valentino Sonia, Voza Antonio, Zaghi Elisa, and Zanon Veronica
Subjects: Metabolome, Microbiota, CHI3L1, COVID-19, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Background and Aims: The SARS-CoV-2 pandemic has overwhelmed the treatment capacity of the health care systems during the highest viral diffusion rate. Patients reaching the emergency department had to be either hospitalized (inpatients) or discharged (outpatients). Still, the decision was taken based on the individual assessment of the actual clinical condition, without specific biomarkers to predict future improvement or deterioration, and discharged patients often returned to the hospital for aggravation of their condition. Here, we have developed a new combined approach of omics to identify factors that could distinguish coronavirus disease 19 (COVID-19) inpatients from outpatients. Methods: Saliva and blood samples were collected over the course of two observational cohort studies. By using machine learning approaches, we compared salivary metabolome of 50 COVID-19 patients with that of 270 healthy individuals having previously been exposed or not to SARS-CoV-2. We then correlated the salivary metabolites that allowed separating COVID-19 inpatients from outpatients with serum biomarkers and salivary microbiota taxa differentially represented in the two groups of patients. Results: We identified nine salivary metabolites that allowed assessing the need of hospitalization. When combined with serum biomarkers, just two salivary metabolites (myo-inositol and 2-pyrrolidineacetic acid) and one serum protein, chitinase 3-like-1 (CHI3L1), were sufficient to separate inpatients from outpatients completely and correlated with modulated microbiota taxa. In particular, we found Corynebacterium 1 to be overrepresented in inpatients, whereas Actinomycetaceae F0332, Candidatus Saccharimonas, and Haemophilus were all underrepresented in the hospitalized population. Conclusion: This is a proof of concept that a combined omic analysis can be used to stratify patients independently from COVID-19.
Published: 2022
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42. Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA)

Author: Daniela Poli, Riccardo Tartaglia, Doris Barcellona, Paolo Bucciarelli, Antonio Ciampa, Elvira Grandone, Giuseppe Malcangi, Giuseppe Rescigno, Vincenzo Toschi, Sophie Testa, and Alessandro Squizzato
Subjects: Anticoagulation, Research, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Clinical research is vital in supporting evidence-based practice. However, several barriers make participation in research difficult. We performed a survey to evaluate the attitude to research of the members of the Italian Anticoagulation Clinics. The survey includes 19 closed questions on the perception of participating in research and exploring the benefit that health professionals wish to obtain. A total of 167 questionnaires were returned from 97/220 (44.1%) Centers, of which 89.7% were not academic. Participants (median age 56 years, range 29-75y; 56.3% females) were equally distributed all over the country; 151/167 (90.4%) of respondents believe that participating in research helps to reduce the routine of their work and allows a better quality of work, 72/167 (43.1%) complain heavy workload. More than 74% of respondents would like to participate in scientific meetings, without difference in relation to age. Instead, inclusion in the authorship of a scientific paper is of relevance for 75.6% of respondents ≤50 years and for 65.2% of respondents >50 years. A substantial positive attitude towards research was evident, suggesting that independent scientific societies could be of valuable support for the growth of research culture.
Published: 2023
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43. Lactobacillus paracasei CNCM I-5220-derived postbiotic protects from the leaky-gut

Author: Francesca Algieri, Nina Tanaskovic, Cindy Cardenas Rincon, Elisabetta Notario, Daniele Braga, Graziano Pesole, Roberto Rusconi, Giuseppe Penna, and Maria Rescigno
Subjects: postbiotic, leaky-gut, Lactobacillus paracasei, tight junction, epithelial barrier integrity, microbiota, Microbiology, QR1-502
Abstract: The maintenance of intestinal barrier function is essential for preventing different pathologies, such as the leaky gut syndrome (LGS), which is characterized by the passage of harmful agents, like bacteria, toxins, and viruses, into the bloodstream. Intestinal barrier integrity is controlled by several players, including the gut microbiota. Various molecules, called postbiotics, are released during the natural metabolic activity of the microbiota. Postbiotics can regulate host–microbe interactions, epithelial homeostasis, and have overall benefits for our health. In this work, we used in vitro and in vivo systems to demonstrate the role of Lactobacillus paracasei CNCM I-5220-derived postbiotic (LP-PBF) in preserving intestinal barrier integrity. We demonstrated in vitro that LP-PBF restored the morphology of tight junctions (TJs) that were altered upon Salmonella typhimurium exposure. In vivo, LP-PBF protected the gut vascular barrier and blocked S. typhimurium dissemination into the bloodstream. Interestingly, we found that LP-PBF interacts not only with the host cells, but also directly with S. typhimurium blocking its biofilm formation, partially due to the presence of biosurfactants. This study highlights that LP-PBF is beneficial in maintaining gut homeostasis due to the synergistic effect of its different components. These results suggest that LP-PBF could be utilized in managing several pathologies displaying an impaired intestinal barrier function.
Published: 2023
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44. Outflowing Helium from a Mature Mini-Neptune

Author: Michael Zhang, Fei Dai, Jacob L. Bean, Heather A. Knutson, and Federica Rescigno
Subjects: Mini Neptunes, Exoplanet atmospheric evolution, Exoplanet atmospheres, Astrophysics, QB460-466
Abstract: We announce the detection of escaping helium from TOI 2134b, a mini-Neptune a few gigayears old. The average in-transit absorption spectrum shows a peak of 0.37% ± 0.05% and an equivalent width of W _avg = 3.3 ± 0.3 mÅ. Among all planets with helium detections, TOI 2134b is the only mature mini-Neptune, has the smallest helium signal, and experiences the lowest X-ray and ultraviolet (XUV) flux. Putting TOI 2134b in the context of all other helium detections, we report the detection of a strong ( p = 3.0 × 10 ^−5 ) and theoretically expected correlation between F _XUV / ρ _XUV (proportional to the energy-limited mass-loss rate) and R _* W _avg (roughly proportional to the observationally inferred mass-loss rate). Here W _avg is the equivalent width of the helium absorption, and ρ _XUV is the density of the planet within the XUV photosphere, but the correlation is similarly strong if we use the optical photosphere. Having the lowest value on both axes, TOI 2134b anchors the relation. We encourage further observations to fill in the missing regions of this parameter space and improve estimates of F _XUV .
Published: 2023
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45. Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters

Author: Maria Rescigno, Chiara Agrati, Carlo Salvarani, Diana Giannarelli, Massimo Costantini, Alberto Mantovani, Raffaella Massafra, Pier Luigi Zinzani, Aldo Morrone, Stefania Notari, Giulia Matusali, Giuseppe Lauria Pinter, Antonio Uccelli, Gennaro Ciliberto, Fausto Baldanti, Franco Locatelli, Nicola Silvestris, Valentina Sinno, Elena Turola, Maria Teresa Lupo-Stanghellini, Giovanni Apolone, the VAX4FRAIL study Group, Fabio Ciceri, Massimo Tommasino, Giuseppe Lauri Pinter, Paolo Corradini, Daniela Fenoglio, Roberta Mortarini, Laura Conti, Chiara Mandoj, Michela Lizier, Stefania Croci, Vito Garrisi, Fulvio Baggi, Tiziana Lazzarotto, Francesca Bonifazi, Concetta Quintarelli, Rita Carsetti, Enrico Girardi, Aurora Bettini, Veronica Bordoni, Concetta Castilletti, Eleonora Cimini, Rita Casetti, Francesca Colavita, Flavia Cristofanelli, Massimo Francalancia, Simona Gili, Delia Goletti, Giulia Gramigna, Germana Grassi, Daniele Lapa, Sara Leone, Davide Mariotti, Silvia Meschi, Enzo Puro, Marika Rubino, Alessandra Sacchi, Eleonora Tartaglia, Silvia Damian, Vincenzo Marasco, Filippo de Braud, Maria Teresa Lupo Stanghellini, Lorenzo Dagna, Francesca Ogliari, Massimo Filippi, Alessandro Bruno, Gloria Catalano, Rosamaria Nitti, Andrea Mengarelli, Francesco Marchesi, Giancarlo Paoletti e Gabriele Minuti, Elena Papa, Elena Azzolini, Luca Germagnoli, Carlo Selmi, Maria De Santis, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Chiara Miggiano, Giulia Fornasa, Sara Monti, Carlo Maurizio Montecucco, Dario Graceffa, Maria Grazia Catanoso, Monica Guberti, Carmine Pinto, Francesco Merli, Franco Valzania, Rosa Divella, Antonio Tufaro, Sabina Delcuratolo, Mariana Miano, Carlo Antozzi, Silvia Bonanno Rita Frangiamore, Lorenzo Maggi, Paolo Pronzato, Matilde Inglese, Carlo Genova, Caterina Lapucci, Alice Laroni, Ilaria Poiré, Marco Fusconi, Vittorio Stefoni, Maria Abbondanza Pantaleo, Serena Di Cosimo, Iolanda Pulice, Roberta Mennitto Fondazione, Stefania Trinca, Giulia Piaggio, Chiara Pozzi, Irene Cassaniti, Alessandro Barberini, Rinaldi Elena, Federica Bortone, Maria Giovanna Dal Bello, and Silvia Corazza
Subjects: SARS-CoV-2 mRNA vaccine, humoral response, T cell response, immunocompromised patients, Omicron neutralization, cross immunity, Immunologic diseases. Allergy, RC581-607
Abstract: IntroductionImmunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.MethodsHere we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dose of mRNA COVID-19 vaccines in patients with hematological malignancies (HM, n=71), solid tumors (ST, n=39) and immune-rheumatological (IR, n=25) diseases. The humoral and T-cell responses to SARS-CoV-2 vaccination were analyzed by quantifying the anti-RBD antibodies, their neutralization activity and the IFN-γ released after spike specific stimulation.ResultsWe show that the T-cell response is similarly boosted by the fourth dose across the different subgroups, while the antibody response is improved only in patients not receiving B-cell targeted therapies, independent on the pathology. However, 9% of patients with anti-RBD antibodies did not have neutralizing antibodies to either virus variants, while an additional 5.7% did not have neutralizing antibodies to Omicron BA.2, making these patients particularly vulnerable to SARS-CoV-2 infection. The increment of neutralizing antibodies was very similar towards Omicron BA.2 and WT virus after the third or fourth dose of vaccine, suggesting that there is no preferential skewing towards either virus variant with the booster dose. The only limited step is the amount of antibodies that are elicited after vaccination, thus increasing the probability of developing neutralizing antibodies to both variants of virus.DiscussionThese data support the recommendation of additional booster doses in frail patients to enhance the development of a B-cell response directed against Omicron and/or to enhance the T-cell response in patients treated with anti-CD20.
Published: 2023
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46. Anticancer properties of bromelain: State-of-the-art and recent trends

Author: Raffaele Pezzani, Manuel Jiménez-Garcia, Xavier Capó, Eda Sönmez Gürer, Farukh Sharopov, Tchokouaha Yamthe Lauve Rachel, David Ntieche Woutouoba, Antonio Rescigno, Stefania Peddio, Paolo Zucca, Patrick Valere Tsouh Fokou, Miquel Martorell, Zehra Gulsunoglu-Konuskan, Alibek Ydyrys, Tynybekov Bekzat, Tussupbekova Gulmira, Christophe Hano, Javad Sharifi-Rad, and Daniela Calina
Subjects: bromelain, cancer, chemotherapeutics, cytotoxicity, apoptosis, molecular targets, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.
Published: 2023
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47. Colorectal cancer, Vitamin D and microbiota: A double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients

Author: Federica Bellerba, Davide Serrano, Johansson Harriet, Chiara Pozzi, Nicola Segata, Amir NabiNejad, Elisa Piperni, Patrizia Gnagnarella, Debora Macis, Valentina Aristarco, Chiara A. Accornero, Paolo Manghi, Aliana Guerrieri Gonzaga, Roberto Biffi, Luca Bottiglieri, Cristina Trovato, Maria Giulia Zampino, Federica Corso, Rino Bellocco, Sara Raimondi, Maria Rescigno, and Sara Gandini
Subjects: Colorectal cancer, Microbiome, Microbiota, Vitamin D, Sex, Gender, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Several studies suggest a role of gut microbiota in colorectal cancer (CRC) initiation and progression. Vitamin D (vitD) blood levels are also inversely correlated with CRC risk and prognosis. However, these factors’ interplay remains unknown. Methods: 74 CRC patients after standard treatment were randomized to 1-year 2000 IU/day vitD or placebo. Baseline and post-treatment fecal microbiota for shotgun metagenomics sequencing was collected. Coda-lasso and Principal Component Analysis were used to select and summarize treatment-associated taxa and pathways. Associations between vitD and taxa/pathways were investigated with logistic regression. Mediation analysis was performed to study if treatment-associated taxa mediated the effect of supplementation on 25(OH)D levels. Cox proportional-hazards model was used for disease-free survival (DFS). Results: 60 patients were analyzed. Change in alpha diversity (Shannon: p = 0.77; Simpson: p = 0.63) and post-treatment beta diversity (p = 0.70) were comparable between arms. Post-treatment abundances of 63 taxa and 32 pathways differed between arms. The 63 taxa also mediated the effect of supplementation on 25(OH)D (p = 0.02). There were sex differences in vitD levels, microbiota and pathways. Pathways of essential amino acids’ biosynthesis were more abundant in supplemented women. Fusobacterium nucleatum presence at baseline was associated with worse DFS (p = 0.02). Those achieving vitD sufficiency (25(OH)D≥30 ng/ml) had lower post-treatment abundances (p = 0.05). Women were more likely to have F. nucleatum post-treatment (p = 0.02). Conclusions: VitD supplementation may contribute shaping the gut microbiota and the microbiota may partially mediate the effect of supplementation on 25(OH)D. The observed sex-specific differences highlight the necessity of including sex/gender as a variable in microbiome studies.
Published: 2022
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48. Biochemical and Phylogenetic Analysis of Italian Phaseolus vulgaris Cultivars as Sources of α-Amylase and α-Glucosidase Inhibitors

Author: Stefania Peddio, Sonia Lorrai, Alessandra Padiglia, Faustina B. Cannea, Tinuccia Dettori, Viviana Cristiglio, Luigi Genovese, Paolo Zucca, and Antonio Rescigno
Subjects: amylase, low-carb diet, biodiversity, bean, diabetes, phytohemagglutinin, Botany, QK1-989
Abstract: Phaseolus vulgaris α-amylase inhibitor (α-AI) is a protein that has recently gained commercial interest, as it inhibits mammalian α-amylase activity, reducing the absorption of dietary carbohydrates. Numerous studies have reported the efficacy of preparations based on this protein on the control of glycaemic peaks in type-2 diabetes patients and in overweight subjects. A positive influence on microbiota regulation has also been described. In this work, ten insufficiently studied Italian P. vulgaris cultivars were screened for α-amylase- and α-glucosidase-inhibiting activity, as well as for the absence of antinutritional compounds, such as phytohemagglutinin (PHA). All the cultivars presented α-glucosidase-inhibitor activity, while α-AI was missing in two of them. Only the Nieddone cultivar (ACC177) had no haemagglutination activity. In addition, the partial nucleotide sequence of the α-AI gene was identified with the degenerate hybrid oligonucleotide primer (CODEHOP) strategy to identify genetic variability, possibly linked to functional α-AI differences, expression of the α-AI gene, and phylogenetic relationships. Molecular studies showed that α-AI was expressed in all the cultivars, and a close similarity between the Pisu Grogu and Fasolu cultivars’ α-AI and α-AI-4 isoform emerged from the comparison of the partially reconstructed primary structures. Moreover, mechanistic models revealed the interaction network that connects α-AI with the α-amylase enzyme characterized by two interaction hotspots (Asp38 and Tyr186), providing some insights for the analysis of the α-AI primary structure from the different cultivars, particularly regarding the structure–activity relationship. This study can broaden the knowledge about this class of proteins, fuelling the valorisation of Italian agronomic biodiversity through the development of commercial preparations from legume cultivars.
Published: 2023
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49. Integrating Red Blood Cell Features and Hemoglobin Levels in Metastatic Renal Cell Carcinoma Patients Treated with Pazopanib or Cabozantinib: An Easily Exploitable Prognostic Score

Author: Giulia Mazzaschi, Alessandro Lazzarin, Matteo Santoni, Francesca Trentini, Ugo De Giorgi, Nicole Brighi, Chiara Tommasi, Silvia Puglisi, Orazio Caffo, Stefania Kinspergher, Alessia Mennitto, Carlo Cattrini, Elena Verzoni, Alessandro Rametta, Marco Stellato, Andrea Malgeri, Giandomenico Roviello, Enrico Maria Silini, Pasquale Rescigno, Sara Elena Rebuzzi, Giuseppe Fornarini, Federico Quaini, Giulia Claire Giudice, Giuseppe Luigi Banna, and Sebastiano Buti
Subjects: metastatic renal cell carcinoma (mrcc), macrocytosis, anisocytosis, anemia, hif, tyrosine-kinase inhibitors, prognostic score, mcv, hb, rdw, Environmental sciences, GE1-350, Microbiology, QR1-502
Abstract: Background: The advent of immune checkpoint inhibitors (ICIs) has revolutionized the metastatic renal cell carcinoma (mRCC) therapeutic landscape. Nevertheless, tyrosine-kinase inhibitors (TKIs) targeting the vascular endothelial growth factor (VEGF) axis still play a key role. The aim of the present study was to explore the prognostic performance of an integrated blood score, based on hemoglobin (Hb) concentration, mean corpuscular volume (MCV), and red cell distribution width (RDW), in mRCC patients treated with anti-VEGF TKIs. The primary endpoint was to correlate Hb, MCV, and RDW with progression-free survival (PFS) and overall survival (OS). Materials and Methods: Our multicenter retrospective observational study involved mRCC patients treated with pazopanib or cabozantinib from January 2012 to December 2020 in nine Italian centers. Clinical records and laboratory data, including Hb levels, MCV, and RDW, were collected at baseline. Descriptive statistics and univariate and multivariate analyses were performed. Results: We enrolled 301 mRCC patients of which 179 (59%) underwent pazopanib, and 122 (41%) cabozantinib. We considered baseline Hb ≥12 g/dL, MCV >87 fL, and RDW ≤16% as good prognostic factors; hence, developing a multiparametric score capable of delineating 4 different categories. The number of good prognostic factors was associated with significantly longer PFS and OS (p < 0.001 for both). Therefore, we developed a red blood cell-based score by stratifying cases into two groups (2–3 versus 0–1, good factors). The impact on PFS and OS was even more striking (median PFS (mPFS): 16.3 vs 7.9 months; median OS (mOS): 33.7 vs 14.1 months)), regardless of the TKI agent. When challenged with univariate and multivariate analysis, the blood score maintained its high prognostic significance in terms of OS (multivariate analysis HR for OS: 0.53, 95% CI 0.39–0.75; p < 0.001, respectively), while the impact on PFS resulted in borderline significance. Conclusions: Our analyses demonstrate the prognostic role of a multiparametric score based on easily exploitable blood parameters, such as Hb concentration, MCV, and RDW. The red blood cell-based score may underlie the upregulation of the HIF-1α pathway and VEGF axis, thereby identifying a selected population who is likely to benefit from TKI therapy.
Published: 2023
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50. Efficacy of Six Different SARS-CoV-2 Vaccines during a Six-Month Follow-Up and Five COVID-19 Waves in Brazil and Mexico

Author: Maria Elena Romero-Ibarguengoitia, Diego Rivera-Salinas, Riccardo Sarti, Riccardo Levi, Maximiliano Mollura, Arnulfo Garza-Silva, Andrea Rivera-Cavazos, Yodira Guadalupe Hernández-Ruíz, Irene Antonieta Barco-Flores, Arnulfo González-Cantú, Miguel Ángel Sanz-Sánchez, Milton Henriques Guimarães Júnior, Chiara Pozzi, Riccardo Barbieri, Devany Paola Morales-Rodriguez, Mauro Martins Texeira, and Maria Rescigno
Subjects: vaccination, SARS-CoV-2, COVID-19, coronavirus, immunization, antibodies, Medicine
Abstract: Comparisons among the different vaccines against SARS-CoV-2 are important to understand which type of vaccine provides more protection. This study aimed to evaluate the real-life efficacy through symptomatic infection and the humoral response of six different vaccines against SARS-CoV-2—BNT162b2, mRNA-1273, ChAdOx1-S, CoronaVac, Ad26.COV2, and Ad5-nCoV. This multicentric observational longitudinal study involved hospitals from Mexico and Brazil in which volunteers who received complete vaccination schemes were followed for 210 days after the last dose. SARS-CoV-2 Spike 1–2 IgG levels were taken before receiving the first vaccine, 21 days after each dose, and the last sample at six months (+/−1 month) after the last dose. A total of 1132 individuals exposed to five COVID-19 waves were included. All vaccines induced humoral responses, and mRNA vaccines had the highest antibody levels during follow-up. At six months, there was a decline in the SARS-CoV-2 Spike 1–2 IgG antibody titers of 69.5% and 36.4% in subjects with negative and positive history of infection respectively. Infection before vaccination and after complete vaccination scheme correlated with higher antibody titers. The predictors of infection were vaccination with CoronaVac compared to BNT162b2 and ChAdOx1-S. In the presence of comorbidities such as diabetes, rheumatoid arthritis, or dyslipidemia, CoronaVac lowered the risk of infection.
Published: 2023
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