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Abstract Highly sensitive and selective gas-sensing materials are critical for applications ranging from environmental monitoring to breath analysis. A rational approach at the nanoscale is urgent to design next-generation sensing devices. In previous work, we unveiled interesting charge transfer channels at the interface between p-type doped graphene and a layer of nickel phthalocyanine (NiPc) molecules, which we believe could be successfully exploited in gas sensing devices. Here, we have investigated the graphene-NiPc interface’s response to adsorbed gas molecules via first-principles calculations. We focused on NH3 and NO2 as test molecules, representing electron donors and acceptors, respectively. Notably, we identified the Ni d z 2 orbital as a key player in mediating the charge transfer and affecting the charge carrier density in graphene. As a proof-of-concept, we then prepared the graphene-NiPc system as a chemiresistor device and exposed it to NH3 and NO2 at room temperature. The sensing tests revealed excellent sensitivity and selectivity, along with a rapid recovery time and a remarkably low detection limit.

Characterization of defects in large 3D printed metals is critical but challenging. This study reports on the X-ray micro-computed tomography (micro-CT) examination of porosities in large-volume 3D-printed and heat-treated titanium (Ti–6Al–4V) alloys, together with their tensile properties and failure mechanisms. Titanium alloy powders were analyzed using scanning electron microscopy (SEM). Laser powder bed fusion (L-PBF) was used to print titanium alloy specimens vertically and horizontally, followed by stress-relieved heat treatment. Micro-CT imaging was performed on printed specimens of 10 × 20 mm3 (diameter × length) to determine their porosities, pore locations and size distributions using an industrial micro-CT system and relevant imaging software. Tensile testing of the processed specimens was conducted to determine their mechanical properties. Optical microscopy and SEM were used to examine the tension-induced failure mechanisms. The results show that porosities, pore sizes and locations were influenced by the build direction, resulting in different mechanical properties. Horizontal printing achieved higher tensile modulus, strength, ductility, resilience and toughness than vertical printing. Heat treatment did not change porosities in horizontally built specimens, but slightly reduced porosities for vertically built ones by 10%. This led to most mechanical properties nearly unchanged for the horizontally printed specimens but remarkably increased yield and tensile strength, and resilience, for the vertically printed ones. All tension-induced fractured surfaces contained pores, possible indicators of failure origins, which should be diminished in advanced processes for higher mechanical reliability.

Land subsidence is a worldwide threat that may cause irreversible damage to the environment and the infrastructures. Thus, identifying and mapping areas prone to land subsidence with accurate methods such as Land Subsidence Susceptibility Index (LSSI) mapping is crucial for mitigating the adverse impacts of this geohazard. Also, Machine Learning (ML) is now becoming a powerful tool to analyze vast and different datasets such as those necessary for LSSI mapping. In this study, we use the conventional Frequency Ratio (FR) method and ML models to generate LSSI maps of the region of Murcia (Spain) where land subsidence occurred in the past due to groundwater overdraft. A LSSI map was initially generated with known FR. Then, additional Conditioning Factors (CFs) with increased spatial resolution were used to train several ML models and generate a new LSSI map. The Extra-Trees Classifier (ETC) outperformed the other approaches, achieving the best performance with a weighted average precision and F1-Score of 0.96, after optimizing its hyperparameters. Then, a third LSSI map was calculated using the FR method and observations of land subsidence from InSAR (Interferometric Synthetic Aperture Radar). This study shows that the effectiveness of using several CFs depends on the added information of each layer. Moreover, the comparison between the different LSSI maps and InSAR data highlights the crucial role of the spatial resolution for accurate mapping, thus enhancing land subsidence risk assessment.

Archivo histórico de Kipus: Revista Andina de Letras y Estudios Culturales, 1995 y 1996.

ABSTRACT: Objectives: K. pneumoniae is a common cause of severe hospital-acquired infections. In the present study, we have characterised the whole-genome of two K. pneumoniae ST437 belonging to the clonal complex CC258. Methods: The whole-genome sequencing was performed by MiSeq Illumina, with a 2 × 300bp paired-end run. ResFinder 4.4.2 was used to detect acquired antimicrobial resistance genes (ARGs) and chromosomal mutations. Mobile genetic elements (plasmids and ISs) were identified by MobileElementFinder v1.0.3. The genome was also assigned to ST using MLST 2.0.9. Virulence factors were detected using the Virulence Factor Database (VFDB). Results: K. pneumoniae KPNAQ_1/23 and KPNAQ_2/23 strains, isolated from urine samples of hospitalised patients, showed resistance to most antibiotics, including ceftazidime-avibactam, ceftolozane-tazobactam, and meropenem-vaborbactam combinations. Both strains were susceptible only to cefiderocol. Multiple mechanisms of resistance were identified. Resistance to β-lactams was due to the presence of NDM-5, OXA-232, CTX-M-15, SHV-182 β-lactamases, and OmpK36 and OmpK37 porin mutations. Resistance to fluoroquinolones was mediated by chromosomal mutations in acrR, oqxAB efflux pumps, and the bifunctional gene aac(6’)-Ib-cr. Conclusion: The presence of different virulence genes makes these KPNAQ_1/23 and KPNAQ_2/23 high-risk clones.

Archivo histórico de Kipus: Revista Andina de Letras y Estudios Culturales, 2000.

Archivo histórico de Kipus: Revista Andina de Letras y Estudios Culturales, 2002.

Abstract Background Reverse Shoulder Arthroplasties (RSA) have become a primary choice for improving shoulder function and pain. However, the biomechanical failure mechanism of the humeral component is still unclear. The present study reports a novel protocol for microstructural imaging of the entire humerus implant under load before and after fracture. Methods A humerus specimen was obtained from a 75-year-old male donor. An expert surgeon implanted the specimen with a commonly used RSA implant (Aequalis reversed II, Stryker Orthopaedics, USA) and surgical procedure. The physiological glenohumeral contact force that maximized the distal implant migration was selected from a public repository ( orthoload.com ). Imaging and concomitant mechanical testing were performed using a large-volume micro-CT scanner (Nikon XT H 225 ST) and a custom-made compressive stage. Both when intact and once implanted, the specimen was tested under a pre-load and by imposing a constant deformation causing a physiological reaction load (650 N, 10 degrees adducted). The deformation of the implanted specimen was then increased up to fracture, which was identified by a sudden drop of the reaction force, and the specimen was then re-scanned. Results The specimen’s stiffness decreased from 874 N/mm to 464 N/mm after implantation, producing movements of the bone-implant interface consistent with the implant’s long-term stability reported in the literature. The micro-CT images displayed fracture of the tuberosity, caused by a combined compression and circumferential tension, induced by the distal migration of the implant. Conclusion The developed protocol offers detailed information on implant mechanics under load relative to intact conditions and fracture, providing insights into the failure mechanics of RSA implants. This protocol can be used to inform future implant design and surgical technique improvements.

Los relatos Tela de sevoya de Myriam Moscona (México) y Poste restante de Cynthia Rimsky (Chile) trabajan la diáspora judía. Se interrogan, desde posiciones transnacionales, acerca de identidades polémicas. Sus viajes son regresos en nombre de otros, padres y abuelos. Nos encontramos con una narrativa errante preocupada por una restitución simbólica, atravesada por cuestiones éticas y políticas acerca de las alteridades. Trazan nuevas líneas entre el dentro y el fuera de los territorios, retornando sobre migraciones en una narrativa preocupada por la restitución. Me interesa la lectura de las memorias culturales de los migrantes y las distancias y rupturas entre territorios y lenguajes. La cuestión de las genealogías se aleja de concepciones esencialistas y el origen puede verse como una fuente de relatos. Los fragmentos forman un archivo lleno de agujeros donde imágenes y palabras son tan importantes como los silencios.

The interannual variability of the physical properties of the shelf waters in Sardinia, western Mediterranean Sea, is studied by using hydrological data gathered during three oceanographic cruises: two in late summer of 2019 and 2021 respectively and another one in early autumn of 2020. The data consist of vertical profiles of salinity and potential temperature acquired by a multiparametric probe for a total of 171 casts performed along a set of transects extending from the nearshore to the continental slope, up to the depth of 200 m. Satellite remote sensing and numerical modelling oceanographic products support the phenomenological analysis. Atlantic Water, characterised by low salinity signatures (S

Background: Education has a pivotal role in preparing society to address the forthcoming health impacts of the climate crisis. Education provides the tools necessary to instil both individual and collective attitudes for mitigating climate change, fosters the development of adaptive skills and mindsets, and promotes a critical understanding of climate change. The aim of the PERSIST project was to assess the effectiveness of a school educational intervention to strengthen literacy on the climate crisis, pro-environmental behaviours, and systems thinking in high school students (aged 14–18 years). Methods: Three meetings were carried out in a scientific high school in the suburbs of Rome (Italy) between March 21, and April 12, 2023, using complex systems models, group activities, and collective discussions. Pre-intervention and post-intervention questionnaires were administered to students to record knowledge, climate-related emotions, and pro-environmental behaviours. Questionnaires that were complete were considered valid. The anonymously collected data were processed using descriptive statistics and t test. Findings: A total of 273 students in ten different classes attending between grades 1 and 4 took part in the project. 78 (36%) participants were female, 133 (62%) were male, and four (2%) did not disclose their gender. The mean age was 15 years. We received 211 pairs of valid pre-intervention and post-intervention questionnaires. The preliminary analysis showed an average increase of 19% in correct responses to knowledge questions, a 21·2% increase in pro-environmental behaviours, and no discernible differences in climate-related emotions between pre-intervention and post-intervention questionnaires. Interpretation: An interactive approach and the use of complex systems might improve students' literacy and attitudes towards the climate crisis, without increasing negative ecological emotions. This pilot project can guide similar, repeatable programmes in other schools and countries and it represents the first measure of climate-related emotions after school intervention. Funding: None.

Abstract Background COVID-19 pandemic represented a shock for healthcare systems. Italy was one of the first country to deal with a huge number of patients to be diagnosed, isolated, and treated with scarce evidence-based guidelines and resources. Several organizational and structural changes were needed to face the pandemic at local level. The article aims at studying the perceived impact of the newly implemented District Operation Centres (DOCs) of Local Health Authority (LHA) Roma 1 in managing active surveillance and home care of COVID-19 patients and their close contacts in cooperation with general practitioners (GPs). Methods A questionnaire, developed according to Delphi methodology, was validated by 7 experts and administered to a randomized sample of GPs and family paediatricians (FPs). All medical doctors selected received a phone interview between December 2020 and January 2021. The questionnaire investigated general characteristics of the sample, relations with DOC and its usefulness, and potential developments. A descriptive analysis was performed and inferential statistical tests were used to assess differences. Results In April 2020 the LHA Roma 1 implemented one DOCs in each local health district. 215 medical doctors were interviewed, reaching the sample target for health districts (80% CL and 10% MOE) and the whole LHA (90% CL and 5% MOE). Several aspects in the management of COVID-19 cases and close contacts of COVID-19 cases, and of the support of DOCs to GPs/FPs were investigated. More than 55% of the GPs and FPs interviewed found the DOCs useful and more than 78% would recommend a service DOC-like to other LHAs. The medical professionals interviewed would use DOCs in the future as support in treating vulnerable patients, utilizing digital health tools, enlisting specialist doctors, establishing networks, and facilitating professional counselling by nurses. Conclusions This study is an attempt to evaluate an organizational change happened during COVID-19 pandemic. DOCs were created to support GPs and FPs as a link between primary healthcare and public health. Although several difficulties were disclosed, DOCs’ experience can help to overcome the fragmentation of the systems and the duality between primary care and public health and make the system more resilient.

This paper presents a passive Envelope Detector (ED) to be used for reception of OOK-modulated signals, such as in Wake-Up Receivers employed within Wireless Sensor Networks, widely used in the IoT. The main goal is implementing a temperature compensation mechanism in order to keep the passive ED input resistance roughly constant over temperature, making it a constant load for the preceding matching network and ultimately keeping the overall receiving chain sensitivity constant over temperature. The proposed ED was designed using STMicroelectronics 90 nm CMOS technology to receive 1 kbps OOK-modulated packets with a 433 MHz carrier frequency and a 0.6 V supply. The use of a block featuring a Proportional-to-Absolute Temperature (PTAT) current yields a 5 dB reduction in sensitivity temperature variation across the −40 °C to 120 °C range. Moreover, two different implementations were compared, one targeting minimal mismatch and the other one targeting minimal area. The minimal area version appears to be better in terms of estimated overall chain sensitivity at all temperatures despite a higher sensitivity spread.

Abstract Non-technical summary Healthcare systems significantly impact the environment, which in turn affects human health. To address this, we propose to revise a popular framework for healthcare improvement, by introducing the advancement of planetary health (the health of both humans and the natural systems) among the aims that health systems should pursue. This approach suggests reducing medical service needs through disease prevention, minimizing environmental impacts, and supporting global efforts to protect planetary health. Practical applications to bring about these pathways are documented in the literature. Technical summary Restoring the health of the planet, with concurrent benefits for human civilization, is paramount. Healthcare systems play a crucial role in this regard, considering the environmental impact of health services. Widely recognized approaches to designing healthcare systems for the optimization of their performance are based on the pursuit of multiple aims, such as the Triple Aim and Quadruple Aim frameworks. The objective of this work is to revise the latter by substituting ‘Advance Planetary Health’ for ‘Improve Population Health’. The objective of advancing planetary health supports all other pre-existing objectives: lowering costs, enhancing patient experience, team wellbeing, and population health, which directly relates to planetary health. Health systems promoting planetary health reduce the need for medical services through disease prevention and health promotion, pursue the provision of appropriate care, minimize the overall environmental impact of medical services, and support planetary health initiatives across all sectors and society. Multiple interconnected pathways exist to operationalize the above components. A revised quadruple aim for healthcare improvement, aligned with social and economic goals of sustainable prosperity and wellbeing, may be a desirable step toward constructing planetary health systems capable of maximizing the health of humans and natural systems. Social media summary It's time for new ‘planetary health systems’: focusing on planetary health to enhance healthcare performance. #PlanetaryHealth #ClimateCrisis #HealthcareImprovement.

Objective: Attention disorder and substance use disorder are linked to driving impairment and increased road crash involvement. This study explores attention deficits in a population of drivers found driving under the influence (DUI) of psychoactive substances. Methods: A case-control study was conducted comparing subjects with a previous DUI episode (cases) to subjects who were negative for DUI offenses (controls). Personal, socio-demographic, and DUI data were collected for both groups. All subjects were administered the Continuous Performance Test–third edition (CPT-3), which measures dimensions of attention, including inattentiveness, impulsivity, sustained attention, and vigilance. Possible associations with a previous DUI episode, the use of illicit substances or excessive alcohol use, and road crash involvement were analyzed statistically. Results: Overall, the study included 147 subjects (100 cases, 47 controls). The parameter distributions of detectability, probability of ADHD, and inattentiveness indicated statistical differences between the two groups. No attention deficits predicted substance use disorder or excessive alcohol consumption. Inattentiveness was an independent risk factor for previous road collision involvement. Conclusions: The results suggest that alterations exist in some attention dimensions in a population of DUI subjects who were users of alcohol or other psychoactive substances and involved in road traffic crashes. The CPT-3 had successfully distinguished between the two study groups, and after validation, it could be useful in the process of reinstating a driver's license. Future research should expand the study sample to better understand the relevance of the proposed methodological approach in terms of prevention, rehabilitation, and the monitoring of subjects evaluated for driving eligibility requirements.

Abstract Background Cities contribute to and are affected by the climate crisis, determining significant health issues in urban settings. Educational institutions have a privileged position to contribute to achieving the transformations needed for a healthier future, so Urban Health education is fundamental to empowering the health of the youth living in cities. This study aims to measure and raise the awareness of Urban Health among students attending a high school in Rome (Italy). Methods An interactive educational intervention, consisting of four sessions, was conducted in a Roman high school during spring 2022. Overall, 319 students aged between 13 and 18 attended the sessions and were asked to complete a 11-items questionnaire before and another after the interventions. Data was gathered anonymously and analyzed using descriptive and inferential statistics. Results Fifty-eight percent of respondents improved their post-intervention questionnaire score, while 15% did not improve and 27% got worse. The mean score significantly improved after the intervention (p

Infections caused by KPC-producing K. pneumoniae continue to pose a significant clinical challenge due to their emerging resistance to new antimicrobials. We investigated the association between two drugs whose roles have been repurposed against multidrug-resistant bacteria: fosfomycin and temocillin. Temocillin exhibits unusual stability against KPC enzymes, while fosfomycin acts as a potent “synergizer”. We conducted in vitro antimicrobial activity studies on 100 clinical isolates of KPC-producing K. pneumoniae using a combination of fosfomycin and temocillin. The results demonstrated synergistic activity in 91% of the isolates. Subsequently, we assessed the effect on Galleria mellonella larvae using five genetically different KPC-Kp isolates. The addition of fosfomycin to temocillin increased larvae survival from 73 to 97% (+Δ 32%; isolate 1), from 93 to 100% (+Δ 7%; isolate 2), from 63 to 86% (+Δ 36%; isolate 3), from 63 to 90% (+Δ 42%; isolate 4), and from 93 to 97% (+Δ 4%; isolate 10). Among the temocillin-resistant KPC-producing K. pneumoniae isolates (24 isolates), the addition of fosfomycin reduced temocillin MIC values below the resistance breakpoint in all isolates except one. Temocillin combined with fosfomycin emerges as a promising combination against KPC-producing K. pneumoniae, warranting further clinical evaluation.

Food safety is a topic of increasing relevance in the European Union (EU). Ensuring safe food from farm to fork is one of the main objectives of EU policies. In our study, we conducted an online survey to assess the food safety knowledge and eating habits in various categories. For young people, we chose school students aged 15–19, based on their ability to cook autonomously after school. For adults, we choose a representative sample consisting of students’ parents and teachers in Chieti and Pescara Provinces of Abruzzo Region (Italy). The survey was structured in eight sections with particular attention to questions regarding risks associated with microorganisms (e.g., Salmonella spp.) and bacterial cross-contamination. Students represented 60.7% of all respondents (n = 290). Risk perception associated with microorganisms in food was significantly different among students and teachers (p

Water stress is an everyday issue in developing countries and especially in Foumban, a municipality located in the West Region of Cameroon between longitudes 10°40’-11°10’E and latitudes 05°30’-05°55’N. The failure of the water distribution system in the Municipality of Foumban (MoF) led the citizens as well as the municipal authorities to exploit groundwater. Unfortunately, an extensive hydrogeophysical field campaign, with incidental cost, is required because the groundwater potential is not priorly assessed. The main objective of this article is to demarcate groundwater potential zones of MoF. For this, six thematic layers contributing to groundwater occurrences are combined using analytical hierarchy process (AHP) on a GIS environment to produce a sound groundwater potential map. This map is classified into three zones: low potential for 39.06%, acceptable potential for 27.27% and high potential for 33.68% of the study area. This may help to increase the rate of productive wells (by focusing hydrogeophysical investigation on areas with high groundwater potential) using little financial resources.

The need to use renewable sources and matrices with energy potential is widely recognized. The development of innovative technologies aimed at the improvement of energy conversion processes and reducing environmental impacts is currently receiving increasing attention from the scientific community and policymakers. The presence of sugars in airborne particle materials is attributed to biomass combustion. For this reason, these compounds are considered markers of biomass burning. The purpose of this work was to evaluate the emissions produced by agroforestry biomass burning (citrus pruning) by simultaneously sampling both stack emissions and atmospheric particulates in the area around a biomass boiler to understand the real contribution of biomass burning to atmospheric pollution. The combustion tests were carried out by comparing the processes with and without particulate abatement system to see how biomass combustion’s contribution to particulate emission can be controlled and reduced. During the tests, the focus was on particulate matter (PM) speciation in terms of sugar marker identification and determination. This study aims to increase knowledge to better understand the contribution of biomass plants to air pollution and differentiate it from the contributions of other sources, such as vehicular traffic or domestic heating.

The injudicious usage of antibiotics during infections caused by Gram-negative bacteria leads to the emergence of β-lactamases. Among them, the NDM-1 enzyme poses a serious threat to human health. Developing new antibiotics or inhibiting β-lactamases might become essential to reduce and prevent bacterial infections. Nanobodies (Nbs), the smallest antigen-binding single-domain fragments derived from Camelidae heavy-chain-only antibodies, targeting enzymes, are innovative alternatives to develop effective inhibitors. The biopanning of an immune VHH library after phage display has helped to retrieve recombinant antibody fragments with high inhibitory activity against recombinant-NDM-1 enzyme. Nb02NDM-1, Nb12NDM-1, and Nb17NDM-1 behaved as uncompetitive inhibitors against NDM-1 with Ki values in the nM range. Remarkably, IC50 values of 25.0 nM and 8.5 nM were noted for Nb02NDM-1 and Nb17NDM-1, respectively. The promising inhibition of NDM-1 by Nbs highlights their potential application in combating particular Gram-negative infections.

Maritime safety and the protection of the marine environment were the primary objectives of two European projects that the National Research Council of Italy had participated in, with numerical applications in two areas located in the northern part of Sardinia, Italy. Specifically, two operational Numerical Prediction Systems (NPS) for pollution risk management were developed; the first was applied to the area of the Bonifacio Strait and the Gulf of Asinara and the second to the port of Olbia. These systems are composed of many oceans and particle tracking numerical models. They are forced with meteorological and ocean data provided by the European Centre for Medium-Range Weather Forecasts and Copernicus Marine Service and their outputs have been compared with in situ measurements for preliminary calibration. A web graphical interface was ad hoc designed, specifically responding to projects’ needs, providing online access to a 3-day oceanographic forecast and advanced diagnostic variables like Oil Stranding Time, Risk Score and Water Age. These products, along with the interactive web platform, prove invaluable for marine spatial planning, prevention and emergency management at sea, for the use of competent governmental and local bodies.

In children, ureteropelvic junction obstruction (UPJO) is mostly caused by intrinsic factors (IUPJO) such as abnormal amounts of muscle and collagen deposition; extrinsic UPJO are rare and often due to crossing vessels (CVs). What is not clear is whether there is also intrinsic UPJ pathology in patients with CV. The aim of our study was to compare the histology of the two types of obstruction and to determine whether these histologic features are distinguishable enough to enable to identify the cause of obstruction based on histologic appearance alone. We retrospectively reviewed pathology reports of 38 children with UPJO that underwent surgery in our hospital from 2008 to 2022. The intrinsic and extrinsic groups consisted of 18 and 20 patients, respectively. After ematoxylin-eosin and Gomori's trichrome staining the specimens were scored for fibrosis and muscular hypertrophy in histhopatology, and CD117 antibody were used to detect interstitial Cajal-like cells. In our study, histological analyses revealed no differences between the CV and IUPJO specimens in terms of presence and degree of fibrosis and muscular hypertrophy; likewise, for presence of interstitial Cajal-like cells.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the pathogen responsible for the pandemic health emergency declared by the World Health Organization in March 2020. During the first part of the pandemic, adults showed mild to severe respiratory symptoms. Children seemed initially exempt, both from acute and subsequent complications. Hyposmia or anosmia were promptly identified as the main symptoms of acute infection, so neurotropism of SARS-CoV-2 was immediately suspected. (1, 2). As the emergency progressed, post infectious neurological complications were described also in pediatric population (3). Cases of cranial neuropathy in connection with acute SARS-CoV-2 infection have been reported in pediatric patients, as an isolate post infectious complication or in the context of the multisystem inflammatory syndrome in children (MIS-C) (4–6). Neuroinflammation is thought to be caused by several mechanisms, among which immune/autoimmune reactions (7), but so far, no specific autoantibody has been identified. SARS-CoV-2 can enter the central nervous system (CNS) directly and/or infect it retrogradely, through the peripheral nervous system (PNS), after replicating peripherally; several factors regulate invasion and subsequent neuroinflammation. Indeed, direct/secondary entry and replication can activate CNS-resident immune cells that, together with peripheral leukocytes, induce an immune response and promote neuroinflammation. In addition, as we will discuss in the following review, many cases of peripheral neuropathy (cranial and non-cranial) have been reported during or after SARS-CoV-2 infection. However, some authors have pointed out that the increase of cranial roots and ganglia in neurological imaging is not always observed in children with cranial neuropathy. (8). Even if a variety of case reports were published, opinions about an increased incidence of such neurologic diseases, linked to SARS-CoV-2 infection, are still controversial (9–11). Facial nerve palsy, ocular movements abnormalities and vestibular alterations are among the most reported issues in pediatric population (3–5). Moreover, an increased screen exposure imposed by social distancing led to acute oculomotion’s disturbance in children, not primarily caused by neuritis (12, 13). The aim of this review is to suggest food for thought on the role of SARS-CoV-2 in neurological conditions, affecting the peripheral nervous system to optimize the management and care of pediatric patients.

In the present study, we analyzed the genome of two S. enterica strains TS1 and TS2 from stool and blood cultures, respectively, and one strain of C. freundii TS3, isolated from a single hospitalized patient with acute myeloid leukemia. The S. enterica Goldcoast ST358 (O:8 (C2-C3) serogroup), sequenced by the MiSeq Illumina system, showed the presence of β-lactamase genes (blaVIM-1, blaSHV-12 and blaOXA-10), aadA1, ant(2″)-Ia, aac(6′)-Iaa, aac(6′)-Ib3, aac(6′)-Ib-cr, qnrVC6, parC(T57S), and several incompatibility plasmids. A wide variety of insertion sequences (ISs) and transposon elements were identified. In C. freundii TS3, these were the blaVIM-1, blaCMY-150, and blaSHV-12, aadA1, aac(6′)-Ib3, aac(6′)-Ib-cr, mph(A), sul1, dfrA14, ARR-2, qnrVC6, and qnrB38. IncA plasmid isolated from E.coli/K12 transconjugant and C. freundii exhibited a sequence identity >99.9%. The transfer of IncA plasmid was evaluated by conjugation experiments.

The objective of this study was to compare the effect of diabetes and pathologies potentially related to diabetes on the risk of infection and death from COVID-19 among people from Highly-Developed-Country (HDC), including Italians, and immigrants from the High-Migratory-Pressure-Countries (HMPC). Among the population with diabetes, whose prevalence is known to be higher among immigrants, we compared the effect of body mass index among HDC and HMPC populations. A population-based cohort study was conducted, using population registries and routinely collected surveillance data. The population was stratified into HDC and HMPC, according to the place of birth; moreover, a focus was set on the South Asiatic population. Analyses restricted to the population with type-2 diabetes were performed. We reported incidence (IRR) and mortality rate ratios (MRR) and hazard ratios (HR) with 95% confidence interval (CI) to estimate the effect of diabetes on SARS-CoV-2 infection and COVID-19 mortality. Overall, IRR of infection and MRR from COVID-19 comparing HMPC with HDC group were 0.84 (95% CI 0.82–0.87) and 0.67 (95% CI 0.46–0.99), respectively. The effect of diabetes on the risk of infection and death from COVID-19 was slightly higher in the HMPC population than in the HDC population (HRs for infection: 1.37 95% CI 1.22–1.53 vs. 1.20 95% CI 1.14–1.25; HRs for mortality: 3.96 95% CI 1.82–8.60 vs. 1.71 95% CI 1.50–1.95, respectively). No substantial difference in the strength of the association was observed between obesity or other comorbidities and SARS-CoV-2 infection. Similarly for COVID-19 mortality, HRs for obesity (HRs: 18.92 95% CI 4.48–79.87 vs. 3.91 95% CI 2.69–5.69) were larger in HMPC than in the HDC population, but differences could be due to chance. Among the population with diabetes, the HMPC group showed similar incidence (IRR: 0.99 95% CI: 0.88–1.12) and mortality (MRR: 0.89 95% CI: 0.49–1.61) to that of HDC individuals. The effect of obesity on incidence was similar in both HDC and HMPC populations (HRs: 1.73 95% CI 1.41–2.11 among HDC vs. 1.41 95% CI 0.63–3.17 among HMPC), although the estimates were very imprecise. Despite a higher prevalence of diabetes and a stronger effect of diabetes on COVID-19 mortality in HMPC than in the HDC population, our cohort did not show an overall excess risk of COVID-19 mortality in immigrants.

Antimicrobial resistance leads to the ineffectiveness of antimicrobials, hampering the ability to cure infections. Zinc-dependent metallo ß-lactamases (MBLs) producing bacteria represent a threat to public health due to limited therapeutic options. Zinc chelators are able to inhibit MBLs and have the potential to restore carbapenem susceptibility. Recently, polypyridine ligands named Bispicen (N,N’-Bis(2-pyridymethyl)-ethylenediamine), Trispicen (N,N,N’-Tris(2-pyridylmethyl)-ethylenediamine), TrispicenA (N,N,N’-tris([2-pyridylmethyl)-ethylenediamine-N’-acetic acid) and TrispicenDALA (N,N,N’-tris([2-pyridylmethyl)-ethylenediamine-N’-acetyl-D-alanyl-D-alanyl-D-alanine methyl ester) were evaluated for their ability to interfere with the Zn-ion network by interactions in the binding site of MBLs. We report on the inhibitory activity of these ligands towards three subclass B1 MBLs (NDM-1, VIM-1 and IMP-1) by kinetic analysis, demonstrating that all compounds, except TrispicenDALA, acted as competitive inhibitors towards NDM-1 and VIM-1. Bispicen was more active against VIM-1 with Ki value of 0.13 μM while NDM-1 was highly inhibited by Trispicen with Ki value of 0.08 μM. The IMP-1 enzyme was resistant to these compounds showing Ki and IC50 values higher than 500 μM. Docking study reveals that all compounds interact with residues of the MBL active site mainly by the formation of pi-interactions and chelation of both Zn ions. Polypyridine ligands deserve attention for their inhibitory potential towards NDM-1 and VIM-1.

Epidemics are dramatic, far-reaching events. Their impact on society is unpredictable. Starting from the meaning of the Greek word epidemia, the paper highlights its topographical and social connotation (“stay at home, stay in a city”), from Homer to Hippocrates. By revisiting some of the most impactful epidemic events in ancient Greece and Rome, some of them well known, it focuses on their social and political consequences, the geographic spread and the medical features, the continuities in the reaction, and in the astonishment of societies. These events are the Athenian so-called plague of 431 BCE; the epidemic cough of Perinthos as narrated in the Hippocratic Collection; the Antonine plague in Rome around 166 CE; the epidemic taking place in China in the same years of the Antonine plague, suggesting a possible connection between the two, at a time when the first direct contacts between the two empires were established. The notion of contagion is considered. The paper also briefly recalls the so-called plague of Justinian, whose fateful aftermath has been often related to the collapse of the Roman Empire. Eventually, a reflection upon the different perceptions of an epidemic can provide us with some food for thought.

Cien años de soledad construye una sociedad patriarcal fallida donde las mujeres ocupan el lugar del mito frente al dinamismo devastador masculi- no. Sus ataduras a las cosas pequeñas, a los gestos domésticos las dotan de «un temible sentido común», un saber negado a los hombres, relacionado con la intuición más que con la razón. Todo Buendía, consciente o incons- cientemente, se siente atraído por la tensión incestuosa que puede des- truirlo. Las aventuras acaecen bajo la doble hegemonía de Úrsula Iguarán y Pilar Ternera. Un mundo que, desde sus orígenes, arrastra el pecado y la culpa, no acepta la diferencia. Los otros –indios, negros, mujeres, extranje- ros– quedan fuera del diseño. La relación entre los sexos está regida por una doble moral. El universo surgido como utopía no puede aceptar el cambio. Sólo puede estar destinado a la derrota.

IntroductionVulvar cancer (VC) accounts for

Este artículo ahonda en las experiencias de formación internacional de estudiantes de Ingeniería Agronómica y Forestal de la Universidad Nacional de La Plata (UNLP) que participaron en movilidades académicas en el marco del Programa de Movilidad Académica Regional para Carreras Acreditadas por el Sistema ARCUSUR y el Programa Argentina-Francia Agricultura. El trabajo parte de los siguientes interrogantes: ¿Qué factores económicos, personales, institucionales y académicos influyen en las experiencias formativas internacionales? ¿Por qué razones las/os estudiantes se involucran en movilidades académicas y qué sentidos le atribuyen a la realización de una experiencia de formación internacional? ¿Qué valoración tienen acerca de lo que aportó el intercambio académico a su formación? Se analizan las experiencias de movilidad para comprender los factores estructurales y subjetivos que interjuegan en su producción en una sociedad caracterizada por múltiples desigualdades. En ese marco, se considera relevante conocer cómo valoran la formación obtenida y los sentidos que le confieren a la internacionalización de los estudios universitarios. La temática, así planteada, supone una doble dimensión de exploración: la condición estudiantil y la dimensión experiencial, en sus articulaciones.

Los silencios de la historia empujan a Elena Poniatowska a visibilizar vidas precarias sustraídas y distorsionadas en la androcéntrica tradición nacional forjada en la revolución. La escritura fabula la alteridad de un sujeto inscripto como contingente y secundario, marcado por la raza, la clase, el sexo y la cultura. Me interesa analizar las representaciones del género y la subalternidad en el imaginario revolucionario: “Mulitas” sir- vientas y soldaderas casi anónimas en contraste con Jesusa Palancares / Josefa Bórquez cuya experiencia domina un testimonio histórico y políti- co. Una fuerte y escéptica crítica a las visiones épicas que se trabaja a través de la ficción y la crónica.

COVID-19 pandemic imposed psychosocial stress increasing in frontline healthcare workers, who managed by responding with different coping strategies. General practitioners were targeted by an extraordinary increase in the demand for reception, diagnosis and treatment from all patients even if working in solo. In Italy, the emergency changed risk assumption and roles in between primary care, unraveling the emotional distress of general practitioners, who suffered not only for isolation, but also emotional threatens. In this correlational study we wanted to evaluate trait anxiety and stress as perceived by general practitioners working in individual ambulatory practice room, and by hospital ward nurses working in group, during a chronic phase (February–May 2021) of COVID-19 pandemic. Our hypothesis is that a different work social organization in clinic contest as for general practitioners compared with nurses could induce adaptive or non-adaptive coping to stress under emergency and mindful attitude could be crucial. A number of 37 general practitioners, and 36 nurses were taken from the sanitary district of ASL1 Avezzano-Sulmona-L’Aquila in Italy. For our analyses we used the Health Professions Stress and Coping Scale to assess the risk of burn-out, and detect the coping strategies. We also used the Cognitive and Affective Mindfulness Scale-Revised, investigating whether clinicians used an eventual mindful attitude to prevent anxiety and responding with adaptive coping strategies. General practitioners reported high levels of anxiety, associated to an increased use of emotional distress. Mindful attitude was protective for anxiety in both general practitioners and nurses. As anxiety increased, it was coped by increasing the demand for social support. This coping strategy correlated with emotional distress and when enhanced, it corresponded to avoidance of the problem. Mindful attitude addressed general practitioners to adaptive coping strategies as the solution of the problem. On the other side, nurses accepted the problem but addressed it to others, by avoiding solving it themselves as beyond their role and organizational responsibility. In conclusion, mindful attitude can prevent dysfunctional reactive behaviors among clinicians at the forefront of emergency and reduce emotional distress for isolation as suffered by general practitioners.

The 2030 Agenda dictated the Sustainable Development Goals. It states the waste reduction needs through their reuse, i.e., considering them as secondary raw materials (Objective 12.5). Bottom ashes from municipal or industrial incinerators can be reused as partial cement replacement in concrete after preventive physical processes such as ferrous metals removal (magnetic separation) and nonferrous metals removal (Eddy current separation). Net of the principal pollutant containment systems, diffusive emissions of fine particles from these processes, coupled with several screening steps and a final long-time open-air residues stabilization, could impact the surrounding environment due to the chemical composition of the particulate matter itself (inorganic and organic pollutants). Moreover, the particulate may also arise from transporting the raw bottom ashes to the pre-treatment plant (point source). The present work aims to predict the concentration of the PM10-bound organic contaminants that are usually sampled weekly (PCDD/Fs, PCBs, PAHs) from the concentration of the daily analyzed inorganic pollutants in the surrounding area of an municipal solid waste slag treatment plant, using Artificial Neural Networks (ANNs) as a forecasting tool. Moreover, ANNs have also been used as a clustering tool to evaluate the plant’s environmental impact on the surrounding area with respect to other additional emission sources.

Brucellosis is a contagious disease caused by bacteria of the genus Brucella, which can affect different animal species. Dogs may occasionally be infected with B. abortus, B. melitensis or B. suis, or by the endemic form of the disease, caused by B. canis. Among the brucellosis‑affecting domestic animals, that of the dog is certainly the least frequent, but also the least studied. Canine brucellosis due to B. canis represents the dog‑specific brucellosis, both because it is the main susceptible animal species, and because it constitutes its fundamental reservoir of infection. The disease can also affect humans, although its course does not assume the characteristics of severity typical of the infection determined by the ‘classical’ species of the genus Brucella. In Italy, there are frequent imports of dogs from countries where the disease is present, often with non‑controlled movements and without sanitary controls. Considering that the zoonotic potential of the disease can be favored by the close cohabitation between man and dog, which occurs especially in urban environments, canine brucellosis has to be regarded as a public health problem susceptible to introduction and spread in the Italian territory.

Objective We aimed at identifying baseline predictive factors for emergency department (ED) readmission, with hospitalisation/death, in patients with COVID-19 previously discharged from the ED. We also developed a disease progression velocity index.Design and setting Retrospective cohort study of prospectively collected data. The charts of consecutive patients with COVID-19 discharged from the Reggio Emilia (Italy) ED (2 March 2 to 31 March 2020) were retrospectively examined. Clinical, laboratory and CT findings at first ED admission were tested as predictive factors using multivariable logistic models. We divided CT extension by days from symptom onset to build a synthetic velocity index.Participants 450 patients discharged from the ED with diagnosis of COVID-19.Main outcome measure ED readmission within 14 days, followed by hospitalisation/death.Results Of the discharged patients, 84 (18.7%) were readmitted to the ED, 61 (13.6%) were hospitalised and 10 (2.2%) died. Age (OR=1.05; 95% CI 1.03 to 1.08), Charlson Comorbidity Index 3 versus 0 (OR=11.61; 95% CI 1.76 to 76.58), days from symptom onset (OR for 1-day increase=0.81; 95% CI 0.73 to 0.90) and CT extension (OR for 1% increase=1.03; 95% CI 1.01 to 1.06) were associated in a multivariable model for readmission with hospitalisation/death. A 2-day lag velocity index was a strong predictor (OR for unit increase=1.21, 95% CI 1.08 to 1.36); the model including this index resulted in less information loss.Conclusions A velocity index combining CT extension and days from symptom onset predicts disease progression in patients with COVID-19. For example, a 20% CT extension 3 days after symptom onset has the same risk as does 50% after 10 days.

We report on the rare case of a male toddler presenting with myoclonic epilepsy characterized by daily episodes of upward movements of the eyebrows, and myoclonic jerks of both head and upper limbs. In addition, the child showed speech delay, tremors, and lack of motor coordination. Next Generation Sequencing analysis (NGS) performed in trio revealed in the proband the c.889C>T de novo missense variant in the KCNA2 gene in heterozygous state. This is the first case of myoclonic epilepsy in a toddler due to a c.889C>T KCNA2 missense variant. The patient was treated with valproic acid and ethosuximide with a good clinical response. At 6 years old, follow-up revealed that the proband was seizure-free with tremors and clumsiness in movements. According to the literature, this case supports the correlation between myoclonic epilepsy and KCNA2 alterations. This evidence suggests that performing genomic testing including the KCNA2 gene in preschool patients affected by myoclonic epilepsy, especially when associated with delayed neurodevelopment. Our goal is to expand the phenotypical spectrum of this rare condition and adding clinical features following a genotype-first approach.

The dramatic increase in infections caused by critically multidrug-resistant bacteria is a global health concern. In this study, we characterized the antimicrobial resistance genes (ARGs) of K. pneumoniae, P. mirabilis, E. cloacae and A. baumannii isolated from both surgical wound and rectal swab of a single Italian patient. Bacterial identification was performed by MALDI-TOF MS and the antimicrobial susceptibility was carried out by Vitek 2 system. The characterization of ARGs was performed using next-generation sequencing (NGS) methodology (MiSeq Illumina apparatus). K. pneumoniae, P. mirabilis and E. cloacae were resistant to most β-lactams and β-lactam/β-lactamases inhibitor combinations. A. baumannii strain was susceptible only to colistin. The presence of plasmids (IncN, IncR, IncFIB, ColRNAI and Col (MGD2)) was detected in all Enterobacterales but not in A. baumannii strain. The IncN plasmid and blaNDM-1 gene were found in K. pneumoniae, P. mirabilis and E. cloacae, suggesting a possible transfer of this gene among the three clinical species. Conjugation experiments were performed using K. pneumoniae (1 isolate), P. mirabilis (2 isolates) and E. cloacae (2 isolates) as donors and E. coli J53 as a recipient. The blaNDM-1 gene was identified by PCR analysis in all transconjugants obtained. The presence of four different bacterial species harboring resistance genes to different classes of antibiotics in a single patient substantially reduced the therapeutic options.

Background The megalichthyids are one of several clades of extinct tetrapodomorph fish that lived throughout the Devonian–Permian periods. They are advanced “osteolepidid-grade” fishes that lived in freshwater swamp and lake environments, with some taxa growing to very large sizes. They bear cosmine-covered bones and a large premaxillary tusk that lies lingually to a row of small teeth. Diagnosis of the family remains controversial with various authors revising it several times in recent works. There are fewer than 10 genera known globally, and only one member definitively identified from Gondwana. Cladarosymblema narrienense Fox et al. 1995 was described from the Lower Carboniferous Raymond Formation in Queensland, Australia, on the basis of several well-preserved specimens. Despite this detailed work, several aspects of its anatomy remain undescribed. Methods Two especially well-preserved 3D fossils of Cladarosymblema narrienense, including the holotype specimen, are scanned using synchrotron or micro-computed tomography (µCT), and 3D modelled using specialist segmentation and visualisation software. New anatomical detail, in particular internal anatomy, is revealed for the first time in this taxon. A novel phylogenetic matrix, adapted from other recent work on tetrapodomorphs, is used to clarify the interrelationships of the megalichthyids and confirm the phylogenetic position of C. narrienense. Results Never before seen morphological details of the palate, hyoid arch, basibranchial skeleton, pectoral girdle and axial skeleton are revealed and described. Several additional features are confirmed or updated from the original description. Moreover, the first full, virtual cranial endocast of any tetrapodomorph fish is presented and described, giving insight into the early neural adaptations in this group. Phylogenetic analysis confirms the monophyly of the Megalichthyidae with seven genera included (Askerichthys, Cladarosymblema, Ectosteorhachis, Mahalalepis, Megalichthys, Palatinichthys, and Sengoerichthys). The position of the megalichthyids as sister group to canowindrids, crownward of “osteolepidids” (e.g.,Osteolepis and Gogonasus), but below “tristichopterids” such as Eusthenopteron is confirmed, but our findings suggest further work is required to resolve megalichthyid interrelationships.

Background: Homophobia or the reaction against homosexuals could be based on the structural ideology of the society, on its institutions or on power relationships, which can incite contempt, sometimes even to deadly violence, regarding those not complying the national culture reference model. Such behaviors are born from the belief that homosexuality must be fought against and opposed as it threatens social order, and could be increased augmented by the campaigns of politicians spread in the mass media. Methods: The aim of this study is to investigate and compare homophobia in Italy and Spain, two Mediterranean countries related from a cultural and traditional background and for general acceptance of homosexuals, and to verify the role of current national culture on recently rising homophobic attitude. Italian and Spanish subjects were studied by means of self-administered questionnaires consisting of: Modern Homophobia Scale to evaluate homophobic attitudes, Homophobia Scale to evaluate the affective, cognitive and behavioral components towards homosexuality, Stereotype Content Model to identify stereotypes about homosexuality, the scale of 11 Emotions and the subscale of Prejudice Attitude Test assessing the social distance, to assess the prejudicial behavior across the two countries. Results: Results showed that despite homophobia levels are low for both populations, with positive emotion and stereotype, Italians showed a greater social distance and a lower quantity and quality of contacts with homosexuals than Spanish. Comparing for political orientation, ideological right-flaw Italians resulted in significantly higher personal discomfort, aggressiveness and cognitive negativism, and lower quantity of contacts than Spanish. Social distance was higher scored in right-flaw than left-flaw oriented subjects from both Italy and Spain, with Italians scoring higher than Spanish. An alternative interpretation of homophobic attitude in Italy, known for recently rising attempts to homosexuals, was provided in comparison with Spain. Political orientation could provide for the differences observed in social distance in each country, but not between them. Specifically, this study’s results indicate that genderist and homophobic campaigns from the Italian right parties could have transmitted values and attitudes of greater prejudice and rejection towards homosexuals. Conclusions: This research contributes to the objective of raising awareness about the mechanisms underlying the homophobic matrix conveyed from national culture, politics and mass media, and its consequences on psycho-social disease.

Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) have limited therapeutic options. Sulbactam-durlobactam is a combination of two βlactamase inhibitors with activity against CRAB under phase 3 clinical investigation. We performed a systematic review on in vitro studies reporting A. baumannii resistances against sulbactam/durlobactam. We considered “resistant” species to be those with MIC ≥ 8 mg/L. Ten studies were included in the review (9754 tested isolates). Overall, 2.3% of A. baumannii were resistant to sulbactam/durlobactam, and this percentage rose to 3.4% among CRAB subgroups and to 3.7% among colistin-resistant strains. Resistance was 100% among metallo β-lactamase-producing strains. Overall, in 12.5% of cases, sulbactam/durlobactam resistance was associated with the production of NDM-1, in 31.7% of cases with the substitutions in the PBP3 determinants, and in the remaining cases the resistance mechanism was unknown. In conclusion, A. baumannii resistance towards sulbactam/durlobactam is limited, except for MBL-producing strains.

Introduction. The Biolabo Solea 100 is a fully automated coagulation analyser using an optical system to detect coagulation designed to meet the needs of small- and medium-sized laboratories. This study aimed to evaluate the analytical performance in terms of bias, precision, and interference of the Biolabo Solea 100 coagulometer under routine laboratory conditions. In addition, a comparison was made with Stago STA-R MAX. Materials and Methods. Imprecision and bias were evaluated for activated partial thromboplastin time (APTT), fibrinogen (FIB), and prothrombin time (PT) at the medical decision levels. The results of 200, 181, and 206 plasma samples for APTT, FIB, and PT, respectively, were compared with those obtained by Stago STA-R MAX. In addition, the interference level of bilirubin, haemoglobin, triglycerides, and fractionated heparin was evaluated. Results. Repeatability, intermediate imprecision, bias, and total error are overall below the defined limits of acceptability. Of interest is the high degree of agreement between Solea 100 and STA-R MAX with respect to PT (s), which fits perfectly with the theoretical line of identity (y = 0 + 1.00x). No interferences were found within the limits stated by the manufacturer, with some exceptions for APTT with heparin and APTT and PT for higher bilirubin concentrations. Conclusions. In conclusion, the performance of the Solea 100 optical analyser is satisfactory and adequate for the determination of routine coagulation tests. Moreover, they are perfectly comparable to mechanical systems, such as STA-R MAX and other upper-level analysers, even considering the low interference levels under routine conditions.

Agricultural activities lead to the production of large quantities of pruning and residual biomass, the correct disposal of which is a topic of great interest. Unfortunately, although it is an environmentally unacceptable practice, disposal often takes place with uncontrolled combustion in field (open burning). Disposal using biomass boilers produces energy from controlled combustion and the use of abatement systems reduces emissions that are inevitably generated in the combustion processes of solid fuel (CO, CO2, NOx, SO2, PM, etc.). Among the pollutants produced in combustion processes, Persistent Organic Pollutants (POPs) are one of the most relevant groups of chemicals that must be monitored for their effect on human health and the environment. This paper reports the data obtained for the emissive characterization of POPs of three different wood biomass prunings (Olive, Citrus and Grapevine) focusing on VOCs, PAHs, PCBs, PCDD/Fs. Emissions samplings were performed at the stack during combustion in a 30 kWth boiler equipped with a multicyclone filter bag for PM abatement in an isokinetic mode in accordance with the CEN and ISO standards methods. Through this work, a complete emission profile of VOCs, PAHs, PCBs, and PCDD/Fs of three different biomass types is provided for the first time, showing that the use of biomass boilers produces quantities of pollutants below the regulatory limits and still lower than those produced by open burning phenomena. Citrus has shown, regarding the other two essences, elevated concentrations in terms of Σ PAH = 174.247 ng/m3, while Olive gave higher results in terms of PCBs and PCDD/Fs (respectively, 39.769 and 3390.63 TEQ pg/Nm3). This is probably due to the high concentration of iron in this biomass (711.44 mg/kg), which during combustion is a catalyst (together with copper) of PCDD/Fs.

Background: Beyond unambiguous advantages of mobile phones (MP), growing evidences document its problematic use and association with mental health issues. Unintentional injuries, such as road traffic or pedestrian accidents, result from dangerous use of the MP (DUMP). The aim of our study was to estimate the prevalence of DUMP and the addiction to MP in young while driving, cycling or walking (defined as DUMP) relating to some demographic and psychological factors. Methods: A cross-sectional prevalence study was carried out on a sample of 1130 Italian university students. The use and addiction to MP were studied with Italian version of the Mobile Phone Use Questionnaire (MPUQ) and Dependence test of MP (DTMP). The Cognitive Behavioral Assessment 2.0 (CBA 2.0) was used to investigate anxiety and obsessive-compulsive disorder. Results: Result statistics showed a continuous use of MP. One third of subjects showed MP addiction, associated to female and younger students. Two thirds showed risk of DUMP, associated to male and older. The obsessive-compulsive disorder was estimated only in a small fraction and significantly correlated with DTMP. Conclusions: Our study points out the importance that information and prevention campaigns targeting specific demographic subpopulations should be sought to raise young awareness for a safe use of MP.

En la intemperie. Poéticas de la fragilidad y la revuelta es el último tomo –y más contemporáneo– de Historia feminista de la literatura argentina, editada por EDUVIM y dirigida por Nora Domínguez, Laura Arnés y María José Punte. Este tomo, coordinado también por Lucía De Leone, se ocupa del siglo XXI. En la introducción nos aguarda un epígrafe de Verónica Gago “La inversión espacial marca una cartografía política de nuevo tipo... estamos construyendo casas abiertas a la calle, al barrio, a las redes comunitarias y un texto y unas paredes que refugian y abrigan sin cesar”. Todas las escrituras están interpeladas por un presente sacudido por movimiento de mujeres, lesbianas, travestis y trans. Conversamos con Nora Domínguez., una de las directoras.

Este trabajo se aproxima a la heterogénea producción ensayística de la escritora mexicana Margo Glantz. Su proyecto de escritura abarca variados gestos genéricos en los que resulta complejo separar el ensayo de la ficción. Los límites entre ambos son imprecisos, con constantes transgresiones. Su escritura se apropia del archivo de la literatura mexicana para reformularlo desde un lugar: el cuerpo de mujer-su propio cuerpo. El artículo se adentra en las lecturas de los imaginarios culturales mexicanos que realiza Glantz a partir de una gramática del cuerpo que, siempre desde el fragmento, le permite contra-hacer y revisar la trama histórica y cultural de América Latina.