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4,828 results on '"Palmer P"'

1. Patient and Healthcare Professional Satisfaction Ratings and Safety Profile of Sufentanil Sublingual Tablets for Treatment of Acute Pain: A Pooled Demographic Analysis

Author: Leiman D, Jové M, Spahn GR, and Palmer P
Subjects: acute pain, demography, global assessment, sublingual administration, sufentanil, surgery, Medicine (General), R5-920
Abstract: David Leiman,1,2 Maurice Jové,3 Gail Rosen Spahn,4 Pamela Palmer4 1HD Research, Houston, TX, USA; 2University of Texas at Houston, Department of Surgery, Houston, TX, USA; 3Atlanta Bone and Joint Specialists, Atlanta, GA, USA; 4Medical Affairs, AcelRx Pharmaceuticals, Inc, Redwood City, CA, USACorrespondence: David Leiman Email leimanmd@gmail.comObjective: This analysis reports the healthcare professional global assessment (HPGA) and patient global assessment (PGA) scores and the adverse event (AE) profile by age, body mass index (BMI), sex, and race from the three Phase III registration studies for sufentanil sublingual tablet (SST) 30 mcg.Methods: Global assessments and treatment-related AEs were analyzed from patients treated with SST 30 mcg for moderate-to-severe acute pain following surgery or in the emergency department (ED). Pooled data were analyzed across patient demographic subgroups.Results: A total of 283 patients were included in the HPGA/PGA analyses. The majority underwent abdominal surgery, with the remaining patients undergoing orthopedic or “other” types of surgery. Overall, SST 30 mcg was highly rated by both healthcare professionals and patients across the demographic subgroups. A total of 323 patients were included in the safety evaluation. The majority of patients did not experience any SST-related AEs; however, those that did experienced common opioid-related side effects such as nausea, headache, dizziness, and vomiting. No patients experienced unexpected AEs or required the use of naloxone.Conclusion: SST 30 mcg was highly rated and well tolerated across demographic subgroups with the majority of patients not experiencing any adverse event related to SST 30 mcg. These findings support the use of sublingual sufentanil in all adult patients, regardless of age, BMI, sex, or race for the treatment of moderate-to-severe acute pain.Keywords: acute pain, demography, global assessment, sublingual administration, sufentanil, surgery
Published: 2021

2. Multi-institutional report of trastuzumab deruxtecan and stereotactic radiosurgery for HER2 positive and HER2-low breast cancer brain metastases

Author: Vaseem M. Khatri, Mariella A. Mestres-Villanueva, Sreenija Yarlagadda, Ajay Doniparthi, David B. Smith, Justyn Y. Nakashima, John M. Bryant, Dekuang Zhao, Rituraj Upadhyay, Matthew N. Mills, Daniel E. Oliver, Hsiang-Hsuan Michael Yu, Joshua D. Palmer, Nicole O. Williams, Reshma L. Mahtani, Manmeet S. Ahluwalia, Hatem H. Soliman, Hyo S. Han, Aixa E. Soyano, Youngchul Kim, Rupesh Kotecha, Sasha J. Beyer, and Kamran A. Ahmed
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Trastuzumab-deruxtecan (T-DXd) has demonstrated intracranial efficacy; however, safety and efficacy data remains limited with stereotactic radiosurgery (SRS). A multi-institutional review was performed with HER2+ or HER2-low metastatic breast cancer treated with T-DXd and SRS for active brain metastases. We identified 215 lesions treated over 48 SRS courses in 34 patients. Median follow up from T-DXd initiation was 13.9 months. The cumulative incidence of symptomatic radiation necrosis at 24 months per lesion was 2.1% and per patient 11%. The 12-month LC was 97%. HER2-low was associated with worse distant intracranial control (DIC) (adjusted HR 2.5, 95% CI 1.1–5.6, p = 0.03) and worse systemic progression free survival (PFS) (HR 4.1, 95% CI 1.6–10.7, p = 0.004). Concurrent SRS and T-DXd has excellent local control, without an increased risk of radiation necrosis. HER2-low disease is associated with worse systemic PFS and DIC with T-DXd compared to HER2+.
Published: 2024
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3. ‘Taking it one day at a time’ and ‘Reaching back out to help someone’: How transgender women living with HIV and community stakeholders navigate violence, oppression, and health through coping and advocacy

Author: Sannisha K. Dale, Peyton R. Willie, Ethel Kirabo Nalule, Camille Lewis, Summer Heard, Nadine Gardner, Chelsie Warman, Kirk Palmer, Belita Wyatt, and Phara Benoit
Subjects: Public aspects of medicine, RA1-1270
Abstract: Abstract Background Transgender women living with HIV face intersectional oppression resulting in consequences for their mental and physical health. Interventions are needed that center the voices of transgender women living with HIV (TWLWH) and community stakeholders engrossed in work on behalf of the transgender community through advocacy and/or work roles. Methods Through a partnership with a trans led and focused program of a community-based health organization and an academic partner, from October 2020 through October 2021, TWLWH and community stakeholders participated in qualitative interviews on trauma, violence, mental health struggles, HIV stigma, gender discrimination, health behaviors (e.g., medication adherence), and their thoughts and recommendations for a proposed intervention. Using a virtual platform (i.e., Zoom or phone) TWLWH and stakeholders were administered a demographics survey via Research Electronic Data Capture (REDCap) and completed individual interviews that were audio recorded. These interviews were analyzed using thematic content analysis. Results All TWLWH and 50% of stakeholders were Black. Qualitative findings highlighted the magnitude of violence, stigma, and discrimination faced by TWLWH and the mental, physical, and economic consequences. Also highlighted were the adaptive strategies TWLWH are utilizing to cope, ways in which invested stakeholders (many of lived expertise) are showing up for women, and acceptability and valuable insights for a proposed intervention. Conclusion TWLWH are navigating a hostile society and multilevel interventions (at the structural, community, interpersonal, and individual levels) centering their voices and those invested in advocating for the community are needed to address the sequelae of oppression they face.
Published: 2024
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4. Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository

Author: John Broach, Chad Achenbach, Stephanie Behar, Laurel O’Connor, Seanan Tarrant, Julia Ferranto, Colton Wright, Paul Hartin, Taylor Orwig, Janvi Nanavati, Benedict Kalibala, Kelsey Woods, Bernadette Shaw, Julie Flahive, Bruce Barton, Nathaniel Hafer, Carly Herbert, Nisha Fahey, Laura Gibson, Karl Simin, Timothy Kowalik, Doyle V. Ward, Agha W. Mirza, Robert L. Murphy, Matthew Caputo, Bryan Buchholz, Heidi Fantasia, Ainat Koren, Lisa Marchand, Simisola Oludare, Felix Sogade, Dana Ritland, Cedrice Davis, Allen Grenier, Christi Baron, Ellie Brent, Jennifer Bacani McKenney, Nancy Elder, LeAnn Michaels, Laura Ferrara, Grant Theron, Zaida Palmer, Barcey Levy, Jeanette Daly, Kim Parang, Megan Schmidt, Denis Buxton, William Heetderks, Yukari C. Manabe, Apurv Soni, and David McManus
Subjects: Infectious and parasitic diseases, RC109-216
Abstract: Abstract Shortly after the first case of SARS-CoV-2 was diagnosed a public health emergency (PHE) was declared and a multi-agency response was initiated within the US federal government to create and propagate testing capacity. As part of this response, an unprecedented program designated Rapid Acceleration of Diagnostics (RADx) Tech was established by the National Institutes of Health (NIH) to facilitate the development of point-of-care tests for the COVID-19. The RADx Tech Clinical Studies Core (CSC), located at the University of Massachusetts Chan Medical School (UMass Chan), with partnering academic, private, and non-governmental organizations around the country, was tasked with developing clinical studies to support this work. This manuscript details development of a biorepository specifically focused on the collection and storage of samples designed for diagnostic platform development. It highlights the unified collection and annotation process that enabled gathering a diverse set of samples. This diversity encompasses the geography and backgrounds of the participants as well as sample characteristics such as variant type and RT-PCR cycle threshold (CT) value of the corresponding reference sample on a uniform clinical reference platform.
Published: 2024
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5. The key role of forest disturbance in reconciling estimates of the northern carbon sink

Author: Michael O’Sullivan, Stephen Sitch, Pierre Friedlingstein, Ingrid T. Luijkx, Wouter Peters, Thais M. Rosan, Almut Arneth, Vivek K. Arora, Naveen Chandra, Frédéric Chevallier, Philippe Ciais, Stefanie Falk, Liang Feng, Thomas Gasser, Richard A. Houghton, Atul K. Jain, Etsushi Kato, Daniel Kennedy, Jürgen Knauer, Matthew J. McGrath, Yosuke Niwa, Paul I. Palmer, Prabir K. Patra, Julia Pongratz, Benjamin Poulter, Christian Rödenbeck, Clemens Schwingshackl, Qing Sun, Hanqin Tian, Anthony P. Walker, Dongxu Yang, Wenping Yuan, Xu Yue, and Sönke Zaehle
Subjects: Geology, QE1-996.5, Environmental sciences, GE1-350
Abstract: Abstract Northern forests are an important carbon sink, but our understanding of the driving factors is limited due to discrepancies between dynamic global vegetation models (DGVMs) and atmospheric inversions. We show that DGVMs simulate a 50% lower sink (1.1 ± 0.5 PgC yr−1 over 2001–2021) across North America, Europe, Russia, and China compared to atmospheric inversions (2.2 ± 0.6 PgC yr−1). We explain why DGVMs underestimate the carbon sink by considering how they represent disturbance processes, specifically the overestimation of fire emissions, and the lack of robust forest demography resulting in lower forest regrowth rates than observed. We reconcile net sink estimates by using alternative disturbance-related fluxes. We estimate carbon uptake through forest regrowth by combining satellite-derived forest age and biomass maps. We calculate a regrowth flux of 1.1 ± 0.1 PgC yr−1, and combine this with satellite-derived estimates of fire emissions (0.4 ± 0.1 PgC yr−1), land-use change emissions from bookkeeping models (0.9 ± 0.2 PgC yr−1), and the DGVM-estimated sink from CO2 fertilisation, nitrogen deposition, and climate change (2.2 ± 0.9 PgC yr−1). The resulting ‘bottom-up’ net flux of 2.1 ± 0.9 PgC yr−1 agrees with atmospheric inversions. The reconciliation holds at regional scales, increasing confidence in our results.
Published: 2024
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6. Enhanced federated anomaly detection through autoencoders using summary statistics-based thresholding

Author: Sofiane Laridi, Gregory Palmer, and Kam-Ming Mark Tam
Subjects: Federated Learning, Anomaly Detection, Autoencoders, Medicine, Science
Abstract: Abstract In Federated Learning, Anomaly Detection poses significant challenges due to the decentralized nature of data, especially under Non-IID distributions. This study proposes a federated threshold calculation method that aggregates summary statistics from normal and anomalous data across clients to create a global threshold for Anomaly Detection with federated Autoencoders, enhancing detection accuracy and robustness while ensuring privacy. Extensive experiments on datasets, including Credit Card Fraud Detection, Shuttle, and Covertype, show that our approach consistently outperforms existing federated and local threshold calculation methods. These findings highlight the potential of summary statistics in improving federated Anomaly Detection under Non-IID conditions.
Published: 2024
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7. Genome-guided isolation of the hyperthermophilic aerobe Fervidibacter sacchari reveals conserved polysaccharide metabolism in the Armatimonadota

Author: Nancy O. Nou, Jonathan K. Covington, Dengxun Lai, Xavier Mayali, Cale O. Seymour, Juliet Johnston, Jian-Yu Jiao, Steffen Buessecker, Damon Mosier, Alise R. Muok, Nicole Torosian, Allison M. Cook, Ariane Briegel, Tanja Woyke, Emiley Eloe-Fadrosh, Nicole Shapiro, Scott G. Bryan, Savannah Sleezer, Joshua Dimapilis, Cristina Gonzalez, Lizett Gonzalez, Marlene Noriega, Matthias Hess, Ross P. Carlson, Lan Liu, Meng-Meng Li, Zheng-Han Lian, Siqi Zhu, Fan Liu, Xian Sun, Beile Gao, Ritesh Mewalal, Miranda Harmon-Smith, Ian K. Blaby, Jan-Fang Cheng, Peter K. Weber, Gabriela Grigorean, Wen-Jun Li, Anne E. Dekas, Jennifer Pett-Ridge, Jeremy A. Dodsworth, Marike Palmer, and Brian P. Hedlund
Subjects: Science
Abstract: Abstract Few aerobic hyperthermophilic microorganisms degrade polysaccharides. Here, we describe the genome-enabled enrichment and optical tweezer-based isolation of an aerobic polysaccharide-degrading hyperthermophile, Fervidibacter sacchari, previously ascribed to candidate phylum Fervidibacteria. F. sacchari uses polysaccharides and monosaccharides for growth at 65–87.5 °C and expresses 191 carbohydrate-active enzymes (CAZymes) according to RNA-Seq and proteomics, including 31 with unusual glycoside hydrolase domains (GH109, GH177, GH179). Fluorescence in-situ hybridization and nanoscale secondary ion mass spectrometry confirmed rapid assimilation of 13C-starch in spring sediments. Purified GHs were optimally active at 80–100 °C on ten different polysaccharides. Finally, we propose reassigning Fervidibacteria as a class within phylum Armatimonadota, along with 18 other species, and show that a high number and diversity of CAZymes is a hallmark of the phylum, in both aerobic and anaerobic lineages. Our study establishes Fervidibacteria as hyperthermophilic polysaccharide degraders in terrestrial geothermal springs and suggests a broad role for Armatimonadota in polysaccharide catabolism.
Published: 2024
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8. Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations

Author: Habiballah Shojaeisaadi, Andrew Schoenrock, Matthew J. Meier, Andrew Williams, Jill M. Norris, Nicholette D. Palmer, Carole L. Yauk, and Francesco Marchetti
Subjects: Biology (General), QH301-705.5
Abstract: Abstract Whole-genome sequencing studies of parent–offspring trios have provided valuable insights into the potential impact of de novo mutations (DNMs) on human health and disease. However, the molecular mechanisms that drive DNMs are unclear. Studies with multi-child families can provide important insight into the causes of inter-family variability in DNM rates but they are highly limited. We characterized 2479 de novo single nucleotide variants (SNVs) in 13 multi-child families of Mexican-American ethnicity. We observed a strong paternal age effect on validated de novo SNVs with extensive inter-family variability in the yearly rate of increase. Children of older fathers showed more C > T transitions at CpG sites than children from younger fathers. Validated SNVs were examined against one cancer (COSMIC) and two non-cancer (human germline and CRISPR-Cas 9 knockout of human DNA repair genes) mutational signature databases. These analyses suggest that inaccurate DNA mismatch repair during repair initiation and excision processes, along with DNA damage and replication errors, are major sources of human germline de novo SNVs. Our findings provide important information for understanding the potential sources of human germline de novo SNVs and the critical role of DNA mismatch repair in their genesis.
Published: 2024
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9. EarthRanger: An open‐source platform for ecosystem monitoring, research and management

Author: Jake Wall, Jes Lefcourt, Chris Jones, Chris Doehring, Dan O'Neill, Dennis Schneider, Jordan Steward, Joshua Krautwurst, Tiffany Wong, Bruce Jones, Karen Goodfellow, Ted Schmitt, Kathleen Gobush, Iain Douglas‐Hamilton, Frank Pope, Eric Schmidt, Jonathan Palmer, Emma Stokes, Andrea Reid, L. Mark Elbroch, Peter Kulits, Catherine Villeneuve, Victor Matsanza, Geoff Clinning, Jordi vanOort, Kristen Denninger Snyder, Alina Peter Daati, Wesley Gold, Stephen Cunliffe, Batian Craig, Barry Cork, Grant Burden, Marc Goss, Nathan Hahn, Sarah Carroll, Eric Gitonga, Ray Rao, Jared A. Stabach, Frédéric Dulude‐de Broin, Patrick Omondi, and George Wittemyer
Subjects: biodiversity, conservation, ecosystem monitoring, GPS tracking, protected area management, real‐time analytics, Ecology, QH540-549.5, Evolution, QH359-425
Abstract: Abstract Effective approaches are needed to conserve the planet's remaining wildlife and wilderness landscapes, especially concerning global biodiversity conservation targets. Here, we present a new software system called EarthRanger: an open‐source platform built to help monitor, research and manage ecosystems. EarthRanger consists of seven main components (Core Server, API, Storage, Gundi, Web App, Mobile App, Ecoscope) that provide functionality for data (i) aggregation & collection, (ii) storage & management, (iii) real‐time and post hoc analysis, (iv) visualisation and (v) dissemination. The mobile application provides field‐based data recording and visualisation tools. EarthRanger may be deployed for single project use or can aggregate across multiple geographies as a centralised hub. EarthRanger can be used to collect standardised tracking data (e.g. from wildlife collars, vehicles and ranger patrols) and configurable event information (e.g. a singular recording with associated user‐defined attribute information such as a wildlife sighting or encounter with a poacher). Since development began in 2015, the platform has (at the time of writing) been deployed at over 500 sites across 70 countries and with myriad configurations and objectives. EarthRanger has improved the ability to monitor data feeds and manage conservation‐related operations in real time. For instance, the deployment of EarthRanger by African Parks has led to the removal of over 50,000 snares, steady population growth of key species of concern and near cessation of poaching. In Liwonde's protected area, enhanced mitigation efforts supported by EarthRanger reduced the number of deaths from wildlife conflict by more than 91%. EarthRanger is also providing a platform to enhance standardisation, aggregation, transfer and long‐term storage of ecological information and promote collaboration between groups conducting protected area management and ecology and biodiversity research.
Published: 2024
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10. Measurement of the B s 0 → J / ψK S 0 $$ {\textrm{B}}_{\textrm{s}}^0\to \textrm{J}/{\uppsi \textrm{K}}_{\textrm{S}}^0 $$ effective lifetime from proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, W. Waltenberger, C.-E. Wulz, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, D. Laroze, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Y. Li, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Carrera Jarrin, A. A. Abdelalim, S. Elgammal, A. Ellithi Kamel, A. Lotfy, M. A. Mahmoud, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, N. Bin Norjoharuddeen, E. Brücken, F. Garcia, P. Inkaew, K. T. S. Kallonen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M. m. Rantanen, H. Siikonen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, M. Kumar, V. Lohezic, J. Malcles, F. Orlandi, L. Portales, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, F. Beaudette, G. Boldrini, P. Busson, A. Cappati, C. Charlot, M. Chiusi, F. Damas, O. Davignon, A. De Wit, I. T. Ehle, B. A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, M. Nguyen, C. Ochando, R. Salerno, J. B. Sauvan, Y. Sirois, L. Urda Gómez, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, S. Falke, U. Goerlach, R. Haeberle, A.-C. Le Bihan, M. Meena, O. Poncet, G. Saha, M. A. Sessini, P. Van Hove, P. Vaucelle, A. Di Florio, D. Amram, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, E. Jourd‘huy, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, D. Chokheli, I. Lomidze, Z. Tsamalaidze, V. Botta, S. Consuegra Rodríguez, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, D. Pérez Adán, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M. y. Lee, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, C. Seth, A. Sharma, J. L. Spah, A. Stein, F. Torres Da Silva De Araujo, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, J. Bach, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, F. Blekman, K. Borras, A. Campbell, A. Cardini, C. Cheng, F. Colombina, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, V. Guglielmi, M. Guthoff, A. Hinzmann, L. Jeppe, B. Kaech, M. Kasemann, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, F. Lorkowski, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, A. B. Meyer, G. Milella, K. Moral Figueroa, A. Mussgiller, L. P. Nair, J. Niedziela, A. Nürnberg, Y. Otarid, J. Park, E. Ranken, A. Raspereza, D. Rastorguev, J. Rübenach, L. Rygaard, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, K. Sharko, M. Shchedrolosiev, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, S. Bollweg, M. Bonanomi, P. Connor, K. El Morabit, Y. Fischer, E. Garutti, A. Grohsjean, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, C. c. Kuo, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, U. Elicabuk, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. 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Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, D. Budkouski, I. Golutvin, I. Gorbunov, V. Karjavine, V. Korenkov, A. Lanev, A. Malakhov, V. Matveev, V. Palichik, V. Perelygin, M. Savina, V. Shalaev, S. Shmatov, S. Shulha, V. Smirnov, O. Teryaev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, G. Gavrilov, V. Golovtcov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, D. Sosnov, V. Sulimov, L. Uvarov, A. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, A. Karneyeu, D. Kirpichnikov, M. Kirsanov, N. Krasnikov, I. Tlisova, A. Toropin, T. Aushev, V. Gavrilov, N. Lychkovskaya, A. Nikitenko, V. Popov, A. Zhokin, R. Chistov, M. Danilov, S. Polikarpov, V. Andreev, M. Azarkin, M. Kirakosyan, A. Terkulov, E. Boos, V. Bunichev, M. Dubinin, L. Dudko, A. Ershov, A. Gribushin, V. Klyukhin, O. Kodolova, S. Obraztsov, S. Petrushanko, V. Savrin, A. Snigirev, V. Blinov, T. Dimova, A. Kozyrev, O. Radchenko, Y. Skovpen, V. Kachanov, D. Konstantinov, S. Slabospitskii, A. Uzunian, A. Babaev, V. Borshch, D. Druzhkin, V. Chekhovsky, and V. Makarenko
Subjects: B Physics, Hadron-Hadron Scattering, Lifetime, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The effective lifetime of the B s 0 $$ {\textrm{B}}_{\textrm{s}}^0 $$ meson in the decay B s 0 → J / ψK S 0 $$ {\textrm{B}}_{\textrm{s}}^0\to \textrm{J}/{\uppsi \textrm{K}}_{\textrm{S}}^0 $$ is measured using data collected during 2016–2018 with the CMS detector in s $$ \sqrt{s} $$ = 13 TeV proton-proton collisions at the LHC, corresponding to an integrated luminosity of 140 fb −1. The effective lifetime is determined by performing a two-dimensional unbinned maximum likelihood fit to the B s 0 $$ {\textrm{B}}_{\textrm{s}}^0 $$ meson invariant mass and proper decay time distributions. The resulting value of 1.59 ± 0.07(stat) ± 0.03(syst) ps is the most precise measurement to date and is in good agreement with the expected value.
Published: 2024
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11. Measurement of differential ZZ + jets production cross sections in pp collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T. T. Tran, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M. A. Shahzad, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S. J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, A. A. Abdelalim, E. Salama, M. A. Mahmoud, Y. Mohammed, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. 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Belyaev, C. Brew, R. M. Brown, D. J. A. Cockerill, C. Cooke, K. V. Ellis, K. Harder, S. Harper, M.-L. Holmberg, J. Linacre, K. Manolopoulos, D. M. Newbold, E. Olaiya, D. Petyt, T. Reis, G. Salvi, T. Schuh, C. H. Shepherd-Themistocleous, I. R. Tomalin, T. Williams, R. Bainbridge, P. Bloch, C. E. Brown, O. Buchmuller, V. Cacchio, C. A. Carrillo Montoya, G. S. Chahal, D. Colling, J. S. Dancu, P. Dauncey, G. Davies, J. Davies, M. Della Negra, S. Fayer, G. Fedi, G. Hall, M. H. Hassanshahi, A. Howard, G. Iles, M. Knight, J. Langford, L. Lyons, A.-M. Magnan, S. Malik, A. Martelli, M. Mieskolainen, J. Nash, M. Pesaresi, B. C. Radburn-Smith, A. Richards, A. Rose, C. Seez, R. Shukla, A. Tapper, K. Uchida, G. P. Uttley, L. H. Vage, T. Virdee, M. Vojinovic, N. Wardle, D. Winterbottom, K. Coldham, J. E. Cole, A. Khan, P. Kyberd, I. D. Reid, S. Abdullin, A. Brinkerhoff, B. Caraway, J. Dittmann, K. Hatakeyama, J. Hiltbrand, A. R. Kanuganti, B. McMaster, M. Saunders, S. Sawant, C. Sutantawibul, M. Toms, J. Wilson, R. Bartek, A. Dominguez, C. Huerta Escamilla, A. E. Simsek, R. Uniyal, A. M. Vargas Hernandez, R. Chudasama, S. I. Cooper, S. V. Gleyzer, C. U. Perez, P. Rumerio, E. Usai, C. West, R. Yi, A. Akpinar, A. Albert, D. Arcaro, C. Cosby, Z. Demiragli, C. Erice, E. Fontanesi, D. Gastler, S. Jeon, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, G. Benelli, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J. M. Hogan, T. Kwon, G. Landsberg, K. T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W. Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P. T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, J. Hauser, M. Ignatenko, M. A. Iqbal, T. Lam, E. Manca, W. A. Nash, D. Saltzberg, B. Stone, V. Valuev, R. Clare, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J. G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B. V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, G. Collura, A. Dorsett, J. Incandela, M. Kilpatrick, A. J. Li, P. Masterson, H. Mei, M. Oshiro, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J. M. Lawhorn, J. Mao, H. B. Newman, T. Q. Nguyen, M. Spiropulu, J. R. Vlimant, S. Xie, R. Y. Zhu, J. Alison, S. An, M. B. Andrews, P. Bryant, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J. P. Cumalat, W. T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, F. Marini, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K. A. Ulmer, S. R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D. J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J. R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L. A. T. Bauerdick, D. Berry, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V. D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R. D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R. S. Kim, T. Kolberg, G. Martinez, H. Prosper, P. R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M. M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, M. R. Adams, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C. E. Gerber, D. J. Hofman, J. h. Lee, D. S. Lemos, A. H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, T. Á. Vámi, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, Y. M. Chen, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M. M. Paranjpe, L. Wang, K. Wong, J. Bendavid, W. Busza, I. A. Cali, Y. Chen, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G. S. F. Stephans, B. Wyslouch, T. J. Yang, B. Crossman, B. M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, L. M. Cremaldi, K. Bloom, M. Bryson, D. R. Claes, C. Fangmeier, F. Golf, G. Haza, J. Hossain, C. Joo, I. Kravchenko, I. Reed, J. E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A. S. Bakshi, V. E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A. G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, M. Chadeeva, V. Chekhovsky, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Hadron-Hadron Scattering, Vector Boson Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Diboson production in association with jets is studied in the fully leptonic final states, pp → (Z/γ *)(Z/γ *) + jets → 2ℓ2ℓ′ + jets, (ℓ, ℓ′ = e or μ) in proton-proton collisions at a center-of-mass energy of 13 TeV. The data sample corresponds to an integrated luminosity of 138 fb −1 collected with the CMS detector at the LHC. Differential distributions and normalized differential cross sections are measured as a function of jet multiplicity, transverse momentum p T, pseudorapidity η, invariant mass and ∆η of the highest-p T and second-highest-p T jets, and as a function of invariant mass of the four-lepton system for events with various jet multiplicities. These differential cross sections are compared with theoretical predictions that mostly agree with the experimental data. However, in a few regions we observe discrepancies between the predicted and measured values. Further improvement of the predictions is required to describe the ZZ+jets production in the whole phase space.
Published: 2024
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12. Seroprevalence and hematological profile of dengue among healthy inhabitants of Mayo Kebbi province: South of Tchad

Author: Mahamat Baharadine Djibrine, Ngum Lesley Ngum, Boda Maurice, Jean Paul Kengne Chedjou, and Palmer Masumbe Netongo
Subjects: dengue, hematological profile, leukopenia, seroprevalence, thrombocytopenia, Medicine
Abstract: Introduction Dengue is one of the most serious and rapidly spreading major mosquito borne diseases in the world. Despite many acute febrile illnesses in Tchad, the burden of illness due to dengue in the country is largely unknown. Hence, the present study aimed to determine the seroprevalence of dengue viral (DENV) infection and its association with hematological parameters. Method A cross sectional study was carried out in Bongor Provincial Hospital. Blood samples were collected from each participant and were used to determine the hematological profile and to diagnose the presence of DENV infection. A total of 130 participants were enrolled in the study. Among these, 114 (87.7%) were diagnosed positive for DENV infection. Results The majority of the positive cases were of the age group 21 to 40 years old. Leukocytosis was the most common hematological parameter affecting 120 (92.3%) of them followed by anemia and thrombocytopenia affecting 69 (53.1%) and 16 (12.3%) of them, respectively, and then lymphocytosis affecting 5 (3.8%) of them. No case of leukopenia was recorded. Discussion The seroprevalence rate among participants suggests that the dengue virus is in circulation in Mayo Kebbi province: south of Tchad. The abnormal hematological parameters may contribute to the severity of the infection like the incidence of bleeding in the case of thrombocytopenia.
Published: 2024
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13. Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions

Author: Maximilian J. Garcia, Monica S. Morales, Tzushan S. Yang, Joseph Holden, Olivia L. Bossardet, Samuel A. Palmer, Marvarakumari Jhala, Stephen Priest, Neeraj Namburu, Nolan Beatty, Sariah E. D’Empaire Salomon, Jordan Vancel, Lauren K. Wareham, and Dolly Ann Padovani-Claudio
Subjects: Medicine, Science
Abstract: Abstract The family of pro-inflammatory and pro-angiogenic chemokines including Interleukin-8 (IL-8, aka CXCL8) and its homologues (CXCL1,2,3,5,6, and 7) exhibit promiscuous binding and activation of several G-protein-coupled receptors (i.e., CXCR2, CXCR1, and the atypical chemokine receptor (ACKR1)). A high proportion of their biological activity is attributed to CXCR2 activation, thus many CXCR2 inhibitors are in clinical trials for several chronic diseases. However, CXCR2 inhibition is often only investigated acutely in these trials or in Cxcr2 −/− mice grown in gnotobiotic conditions. Since humans do not live in germ-free environments, our first goal is to highlight novel retinal and systemic observations in Cxcr2 −/− mice grown in non-gnotobiotic conditions that suggest potential harmful consequences of long-term CXCR2 deficiency or blockade. Beyond confirmation of circulating blood/immune cell-related phenotypes, we report novel findings in Cxcr2 −/− mice including: (1) delayed dye transit to the retinal vasculature, (2) alterations in the density and distribution of retinal vessels, astrocytes and microglia, (3) decreased electroretinogram a- and b-wave amplitudes, (4) reduced visual acuity, and (5) increased polymorphonuclear cell accumulation in vascular lumina abutting venular walls in the retina and in vital non-ocular tissues (lung and liver). Furthermore, PheWAS of CXCR2 CXCR1, and ACKR1 gene variants using data from UK Biobank participants suggest clinical associations with both retinal and vascular disease phenotypes. We conclude that chronic CXCR2 deficiency in mice contributes to functional damage to the retina and that the long-term safety of CXCR1/2 inhibitors designed for chronic use in humans should be explored before clinical adoption to safeguard sight and overall vascular health.
Published: 2024
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14. Assessment of disability and disease burden in neuromyelitis optica spectrum disorders in the CIRCLES Cohort

Author: Shervin Gholizadeh, Alex Exuzides, Jennifer Sinnott, Chella Palmer, Michael Waltz, John W. Rose, Anna Marie Jolley, Jacinta M. Behne, Megan K. Behne, Terrence F. Blaschke, Terry J. Smith, Katelyn E. Lewis, Lawrence J. Cook, Michael R. Yeaman, and on behalf of The Guthy-Jackson Charitable Foundation CIRCLES Study Group
Subjects: Medicine, Science
Abstract: Abstract Neuromyelitis optica spectrum disorders (NMOSD) comprise autoimmune diseases imposing substantial disability. We compared an NMOSD-targeted disability assessment of mobility, vision, and self-care domains (individually and composite) with the multiple sclerosis-targeted Expanded Disability Status Scale (EDSS) to assess NMOSD disease burden. An overall cohort (n = 505) and a subset of these patients with an enriched dataset (n = 198) were analyzed from the CIRCLES longitudinal, observational database of patients with AQP4-IgG–seropositive or –seronegative NMOSD in North America. Multinomial modeling was used to identify temporal correlates of disability improvement, stability, and worsening. Prior on-study relapse correlated with worsening mobility (OR, 3.08; 95% CI: 1.61–5.90), vision (OR, 3.99; 95% CI: 2.03–7.86), self-care disability (OR, 1.90; 95% CI: 1.07–3.38), and mean composite index disability (OR, 4.20; 95% CI: 1.71–10.34). Higher vision disability was associated with Black race, shorter time on-study, and AQP4-IgG–seropositive status in patients ≥ 18 years (p
Published: 2024
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15. SLC16A8 is a causal contributor to age-related macular degeneration risk

Author: Navid Nouri, Bailey Hannon Gussler, Amy Stockwell, Tom Truong, Gyeong Jin Kang, Kristen C. Browder, Yann Malato, Abdoulaye Sene, Sherri Van Everen, Charles C. Wykoff, David Brown, Arthur Fu, James D. Palmer, Jose Ronaldo Lima de Carvalho, Ehsan Ullah, Ranya Al Rawi, Emily Y. Chew, Wadih M. Zein, Bin Guan, Mark I. McCarthy, Jeffrey W. Hofmann, Shawnta Y. Chaney, Heinrich Jasper, and Brian L. Yaspan
Subjects: Medicine, Genetics, QH426-470
Abstract: Abstract Age-related macular degeneration (AMD), a complex neurodegenerative disease, is a leading cause of visual impairment worldwide with a strong genetic component. Genetic studies have identified several loci, but few causal genes with functional characterization. Here we highlight multiple lines of evidence which show a causal role in AMD for SLC16A8, which encodes MCT3, a retinal pigment epithelium (RPE) specific lactate transporter. First, in an unbiased, genome-wide analysis of rare coding variants we show multiple SLC16A8 rare variants are associated with AMD risk, corroborating previous borderline significant reports from AMD rare variant studies. Second, we report a novel SLC16A8 mutation in a three-generation family with early onset macular degeneration. Finally, mis-expression in multiple model organisms shows functional and anatomic retinal consequences. This study highlights the important role for SLC16A8 and lactate regulation towards outer retina/RPE health and highlights a potential new therapeutic opportunity for the treatment of AMD.
Published: 2024
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16. Trends in maternal body mass index, macrosomia and caesarean section in first-time mothers during the pandemic: a multicentre retrospective cohort study of 12 Melbourne public hospitals

Author: Andrew J. Goldsack, Melvin B. Marzan, Daniel L. Rolnik, Anthea C. Lindquist, Joanne M. Said, Kirsten R. Palmer, Penelope M. Sheehan, Stephanie Potenza, Natasha Pritchard, Clare L. Whitehead, Jolyon Ford, Ben W. Mol, Susan P. Walker, and Lisa Hui
Subjects: Obesity, COVID-19, Pregnancy, Birthweight, Pregnancy complications, Gynecology and obstetrics, RG1-991
Abstract: Abstract Objective To compare specific perinatal outcomes in nulliparas with a singleton infant in cephalic presentation at term, with and without exposure to the COVID-19 pandemic during pregnancy. We hypothesised that the pandemic conditions in Melbourne may have been an independent contributor to trends in maternal Body Mass Index ≥ 25 kg/m2, macrosomia and caesarean section. Design Multi-centre retrospective cohort study and interrupted time-series analysis. Setting Metropolitan Melbourne, Victoria. Population Singleton infants ≥ 20 weeks gestational age born between 1 January 2019 and 31 March 2022. Main outcome measures Rates of maternal Body Mass Index ≥ 25 kg/m2, macrosomia (birthweight ≥ 4000 g) and caesarean section. Results 25 897 individuals gave birth for the first time to a singleton infant in cephalic presentation at term in the pre-pandemic cohort, and 25 298 in the pandemic-exposed cohort. Interrupted time-series analysis demonstrated no significant additional effect of the pandemic on pre-existing upward trends in maternal Body Mass Index ≥ 25 kg/m2, caesarean section or macrosomia. The rate of maternal Body Mass Index ≥ 25 kg/m2 was higher in the pandemic-exposed cohort compared with the pre-pandemic cohort, (45.82% vs. 44.58% respectively, p = 0.041) as was the overall rate of caesarean section (33.09% vs. 30.80%, p
Published: 2024
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17. Investigation into the Acceptability of Moderate-to-Large Volume Subcutaneous Injections in Healthy Volunteers: Results from a Single-Center Randomized Controlled Study

Author: Akinseye C, Fiorini A, Jarvis EL, Fry M, Raza A, Soleman S, Igwe S, and Palmer M
Subjects: drug delivery system, skin, formulation, pain scores, tolerability and acceptability questionnaire, Medical technology, R855-855.5
Abstract: Chika Akinseye,1 Andrew Fiorini,2 Emily Louise Jarvis,3 Michelle Fry,4 Abid Raza,5 Sara Soleman,6 Stephanie Igwe,6 Mark Palmer2 1GSK R&D, Discovery Medicine, Stevenage, UK; 2GSK R&D, Device Engineering, Ware, UK; 3GSK R&D, Biostatistics, Stevenage, UK; 4GSK Rx Global Clinical Delivery, Stockley Park, UK; 5GSK R&D, Stockley Park, UK; 6GSK Clinical Unit, Addenbrooke’s Centre for Clinical Investigation, Cambridge, UKCorrespondence: Mark Palmer, GSK R&D, Harris’s Lane Ware, Hertfordshire, SG12 0DP, United Kingdom, Email mark.g.palmer@gsk.comPurpose: Therapeutic proteins are often delivered by subcutaneous (SC) autoinjector to enable self-administration. Autoinjectors typically deliver up to 1 mL injected volumes per dose. Delivery of larger volumes may be limited by injection site discomfort, including pain, swelling, and redness. Delivery at a slower rate may mitigate this discomfort. This single-center, randomized, crossover study evaluated the acceptability and tolerability of varying volumes and delivery rates of SC saline in healthy volunteers.Patients and Methods: Eligible participants were adults (18– 65 years) with a body mass index of 18.5– 32.0 kg/m2. Participants (N = 24) were randomized to multiple sequences of infusions over five visits, with infusions ranging from 1 to 5 mL at rates of 1.50– 6.00 mL/minute (min) and including a 1 mL SC infusion in 10 seconds (s) at a rate of 6.00 mL/min. The primary objective was to identify acceptable volume and delivery rates of SC saline, as assessed by visual analogue scale (VAS) pain scores, a tolerability and acceptability questionnaire, and infusion leakage.Results: Infusions that met the acceptability criteria were 1 mL in 10s, 4 mL in 58s, and 3 mL in 2 mins. Higher delivery volumes and rates were associated with higher VAS pain scores but remained within the VAS acceptability criteria.Conclusion: These findings may support the development of larger-volume injectors for self-administration of future medicines.Keywords: drug delivery system, skin, formulation, pain scores, tolerability and acceptability questionnaire
Published: 2024

18. Building common understanding: seeking consensus and defining social prescribing across contexts – a collective commentary on a Delphi study

Author: Caitlin Muhl, Kate Mulligan, Bogdan Chiva Giurca, Marie J. Polley, Gary Bloch, Dominik Alex Nowak, Charlotte Osborn-Forde, Sonia Hsiung, Kheng Hock Lee, Wolfram J. Herrmann, James Robert Baker, Dame Helen Jayne Stokes-Lampard, Sir Sam Everington, Michael Dixon, Isabelle Wachsmuth, Cristiano Figueiredo, Halfdan Thorsø Skjerning, Daniela Rojatz, Yu-Da Chen, Miriam L. Heijnders, Carolyn Wallace, Michelle Howarth, Daisuke Watanabe, Marcello Bertotti, Anu Helena Jansson, Susanna Althini, Felix Holzinger, Darren Glyn Dooler, Siân Brand, Tim James Anfilogoff, Daisy Fancourt, Michelle L. A. Nelson, Stephanie Tierney, Alison Leitch, Hae-Kweun Nam, Kiffer G. Card, Daniel Hayes, Siân Slade, Marie Anne Essam, Gay Anthia Palmer, Vivian Andrea Welch, David Robinson, Laurie Hilsgen, Niall Taylor, Rasmus Østergaard Nielsen, Dragana Vidovic, Emer Maeve McDaid, Louíse Viecili Hoffmeister, Jill Bonehill, Alan Siegel, Alžběta Bártová, David Acurio-Páez, Juan Manuel Mendive, and Kerryn Husk
Subjects: Commentary, Global definition, Social prescribing, Public aspects of medicine, RA1-1270
Abstract: Abstract Social prescribing has become a global phenomenon. A Delphi study was recently conducted with 48 social prescribing experts from 26 countries to establish global agreement on the definition of social prescribing. We reflect on the use and utility of the outputs of this work, and where we go from here.
Published: 2024
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19. Chronic hypoxia for the adaptation of extracellular vesicle phenotype

Author: Chris S. Pridgeon, Kerttu Airavaara, Julia Monola, Alisa Jokela, Daniel Palmer, Marjo Yliperttula, and Riina Harjumäki
Subjects: Medicine, Science
Abstract: Abstract Variations in oxygen level affect the phenotype of cells and extracellular vesicles (EVs). Depending on the metabolic oxygen demand of cells, hypoxic cell culture can produce conditions more like those found in vivo, and with appropriate oxygen levels, mimic hypoxic tumours. However, most previous experiments studying both EVs and the effects of hypoxia on cells use periods of 72 h or less of hypoxia. We hypothesised that this was insufficient time for adaptation to hypoxic conditions both for EVs and cells which may skew the results of such studies. In this study, the effects of acute (72 h) and chronic hypoxia (> 2 weeks) on the phenotype of HepG2 and PC3 cells and their EVs were examined. Cells could be cultured normally under chronic hypoxic conditions and cryopreserved and recovered. The effects of hypoxia on EV phenotype are slow to establish and dependent on cell line. In PC3 cells, the greatest change in phenotype and increase in EV production occurred only with chronic hypoxic culture. In HepG2 cells, the number of EVs produced was insensitive to hypoxic culture and the greatest changes in protein expression were observed after acute hypoxic culture. Nonetheless, biphasic changes in EV phenotype were detected in both cell types in response to either acute or chronic hypoxia. These results indicate that for cells which do not induce consumptive oxygen depletion, prolonged hypoxic culture is required for complete adaptation.
Published: 2024
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20. Holy grail or convenient excuse? Stakeholder perspectives on the role of health system strengthening evaluation in global health resource allocation

Author: Veena Sriram, Natasha Palmer, Shreya Pereira, and Sara Bennett
Subjects: Health systems strengthening, Evaluation, Global health governance, Politics of evidence, Stakeholder analysis, Resource allocation, Public aspects of medicine, RA1-1270
Abstract: Abstract Background The role of evaluation evidence in guiding health systems strengthening (HSS) investments at the global-level remains contested. A lack of rigorous impact evaluations is viewed by some as an obstacle to scaling resources. However, others suggest that power dynamics and knowledge hierarchies continue to shape perceptions of rigor and acceptability in HSS evaluations. This debate has had major implications on HSS resource allocation in global-level funding decisions. Yet, few studies have examined the relationship between HSS evaluation evidence and prioritization of HSS. In this paper, we explore the perspectives of key global health stakeholders, specifically around the nature of evidence sought regarding HSS and its potential impact on prioritization, the challenges in securing such evidence, and the drivers of intra- and inter-organizational divergences. We conducted a stakeholder analysis, drawing on 25 interviews with senior representatives of major global health organizations, and utilized inductive approaches to data analysis to develop themes. Results Our analysis suggests an intractable challenge at the heart of the relationship between HSS evaluations and prioritization. A lack of evidence was used as a reason for limited investments by some respondents, citing their belief that HSS was an unproven and potentially risky investment which is driven by the philosophy of HSS advocates rather than evidence. The same respondents also noted that the ‘holy grail’ of evaluation evidence that they sought would be rigorous studies that assess the impact of investments on health outcomes and financial accountability, and believed that methodological innovations to deliver this have not occurred. Conversely, others held HSS as a cross-cutting principle across global health investment decisions, and felt that the type of evidence sought by some funders is unachievable and not necessary – an ‘elusive quest’ – given methodological challenges in establishing causality and attribution. In their view, evidence would not change perspectives in favor of HSS investments, and evidence gaps were used as a ‘convenient excuse’. Respondents raised additional concerns regarding the design, dissemination and translation of HSS evaluation evidence. Conclusions Ongoing debates about the need for stronger evidence on HSS are often conducted at cross-purposes. Acknowledging and navigating these differing perspectives on HSS evaluation may help break the gridlock and find a more productive way forward.
Published: 2024
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21. Pharmacokinetic interaction between single and multiple doses of darunavir, in combination with cobicistat or ritonavir, and single-dose dabigatran etexilate in healthy adults

Author: Sandy Van Hemelryck, Erika Van Landuyt, Jay Ariyawansa, Martyn Palmer, Martine J. C. Kothe, and Caroline Pollefliet
Subjects: Darunavir, Ritonavir, Cobicistat, Dabigatran, Drug-drug interaction, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441
Abstract: Abstract Objective Darunavir (DRV) is a P-glycoprotein (P-gp) inhibitor. Dabigatran etexilate, prodrug of the anticoagulant dabigatran, is a P-gp probe substrate. This study evaluated the effect of single and multiple doses of DRV, coadministered with cobicistat (COBI) or ritonavir (rtv), on the pharmacokinetics (PK) of single-dose dabigatran etexilate. Methods This was an open-label, fixed-sequence, single-center, 2-panel, phase 1 study in which healthy adult participants were equally divided over 2 panels. In panel 1, participants received single and multiple doses of DRV/COBI 800/150 mg coadministered with single-dose dabigatran etexilate 150 mg. In panel 2, participants received single and multiple doses of DRV 800 mg + rtv 100 mg coadministered with single-dose dabigatran etexilate 150 mg. Key PK parameters evaluated were maximum plasma concentration (Cmax) and area under the plasma concentration-time curve from time zero to infinity (AUCinf) for free and total dabigatran. Results Overall, 28 participants were enrolled and treated (n = 14 per panel). Dabigatran Cmax and AUCinf increased 2.64-fold after a single dose of DRV/COBI and 1.99- and 1.88-fold, respectively, after multiple doses of DRV/COBI. Dabigatran Cmax and AUCinf increased 1.64- and 1.72-fold, respectively, after a single dose of DRV + rtv and 1.22- and 1.18-fold, respectively, after multiple doses of DRV + rtv. In both panels, the most commonly reported adverse events were diarrhea and headache. Conclusion Findings of increased dabigatran exposure with DRV/COBI or DRV + rtv coadministration indicate an inhibitory effect of single-dose boosted DRV on P-gp, and a mixed inhibitory/inductive effect of multiple doses of boosted DRV on P-gp. Trial registration ClinicalTrials.gov, NCT04208061 . Registered December 19, 2019
Published: 2024
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22. Observation of the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ Λ b 0 → J / ψ Ξ - K + decay

Author: CMS Collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T. T. Tran, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M. A. Shahzad, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S. J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M. Abdullah Al-Mashad, M. A. Mahmoud, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K. T. S. Kallonen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M. M. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, G. Adamov, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M. Y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, A. Sharma, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N. Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A. B. Meyer, G. Milella, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, M. Shchedrolosiev, R. E. Sosa Ricardo, L. P. Sreelatha Pramod, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H. J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R. F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M. M. A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A. J. Rádl, G. I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S. B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, M. Meena, K. Sandeep, T. Sheokand, J. B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B. C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Acharya, S. Baradia, S. Barman, D. Bhowmik, S. Dutta, B. Gomber, P. Palit, G. Saha, B. Sahu, S. Sarkar, M. M. Ameen, P. K. Behera, S. C. Behera, P. Jana, P. Kalbhor, J. R. Komaragiri, D. Kumar, L. Panwar, R. Pradhan, P. R. Pujahari, N. R. Saha, A. K. Sikdar, S. Verma, T. Aziz, I. Das, S. Dugad, M. Kumar, G. B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R. M. Chatterjee, M. Guchait, Sh. Jain, S. Karmakar, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, A. K. Das, C. Kar, D. Maity, P. Mal, T. Mishra, V. K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S. K. Swain, S. Varghese, D. Vats, A. Alpana, S. Dube, B. Kansal, A. Laha, A. Rastogi, S. 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Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A. S. Bakshi, V. E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A. G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, M. Sergeev, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Using proton–proton collision data corresponding to an integrated luminosity of $$140\hbox { fb}^{-1}$$ 140 fb - 1 collected by the CMS experiment at $$\sqrt{s}= 13\,\text {Te}\hspace{-.08em}\text {V} $$ s = 13 Te V , the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ Λ b 0 → J / ψ Ξ - K + decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} $$ Λ b 0 → ψ ( 2 S ) Λ decay, is measured to be $$\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} )/\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} ) = [3.38\pm 1.02\pm 0.61\pm 0.03]\%$$ B ( Λ b 0 → J / ψ Ξ - K + ) / B ( Λ b 0 → ψ ( 2 S ) Λ ) = [ 3.38 ± 1.02 ± 0.61 ± 0.03 ] % , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in $$\mathcal {B}({{{\uppsi }} ({2\textrm{S}})} \rightarrow {{\text {J}/\uppsi }} {{{\uppi }} ^{{+}}} {{{\uppi }} ^{{-}}} )$$ B ( ψ ( 2 S ) → J / ψ π + π - ) and $$\mathcal {B}({{{\Xi }} ^{{-}}} \rightarrow {{\Lambda }} {{{\uppi }} ^{{-}}} )$$ B ( Ξ - → Λ π - ) .
Published: 2024
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23. Search for Higgs boson pair production with one associated vector boson in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T. T. Tran, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. 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Uplegger, E. W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R. D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R. S. Kim, T. Kolberg, G. Martinez, H. Prosper, P. R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M. M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, M. R. Adams, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C. E. Gerber, D. J. Hofman, J. h. Lee, D. S. Lemos, A. H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, T. Á. Vámi, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, Y. M. Chen, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, B. Kronheim, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M. M. Paranjpe, L. Wang, K. Wong, J. Bendavid, W. Busza, I. A. Cali, Y. Chen, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G. S. F. Stephans, B. Wyslouch, T. J. Yang, B. Crossman, B. M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, L. M. Cremaldi, K. Bloom, M. Bryson, D. R. Claes, C. Fangmeier, F. Golf, J. Hossain, C. Joo, I. Kravchenko, I. Reed, J. E. Siado, G. R. Snow, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A. S. Bakshi, V. E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A. G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Hadron-Hadron Scattering, Higgs Physics, Vector Boson Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for Higgs boson pair (HH) production in association with a vector boson V (W or Z boson) is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb −1. Both hadronic and leptonic decays of V bosons are used. The leptons considered are electrons, muons, and neutrinos. The HH production is searched for in the b b ¯ b b ¯ $$ \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}} $$ decay channel. An observed (expected) upper limit at 95% confidence level of VHH production cross section is set at 294 (124) times the standard model prediction. Constraints are also set on the modifiers of the Higgs boson trilinear self-coupling, k λ , assuming k 2V = 1, and vice versa on the coupling of two Higgs bosons with two vector bosons, k 2V. The observed (expected) 95% confidence intervals of these coupling modifiers are −37.7 < k λ < 37.2 (−30.1 < k λ < 28.9) and −12.2 < k 2V < 13.5 (−7.2 < k 2V < 8.9), respectively.
Published: 2024
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24. PAGER: A novel genotype encoding strategy for modeling deviations from additivity in complex trait association studies

Author: Philip J. Freda, Attri Ghosh, Priyanka Bhandary, Nicholas Matsumoto, Apurva S. Chitre, Jiayan Zhou, Molly A. Hall, Abraham A. Palmer, Tayo Obafemi-Ajayi, and Jason H. Moore
Subjects: Association studies, Case-control, Dominance, Genetics, Genotype encoding, GWAS, Computer applications to medicine. Medical informatics, R858-859.7, Analysis, QA299.6-433
Abstract: Abstract Background The additive model of inheritance assumes that heterozygotes (Aa) are exactly intermediate in respect to homozygotes (AA and aa). While this model is commonly used in single-locus genetic association studies, significant deviations from additivity are well-documented and contribute to phenotypic variance across many traits and systems. This assumption can introduce type I and type II errors by overestimating or underestimating the effects of variants that deviate from additivity. Alternative genotype encoding strategies have been explored to account for different inheritance patterns, but they often incur significant computational or methodological costs. To address these challenges, we introduce PAGER (Phenotype Adjusted Genotype Encoding and Ranking), an efficient pre-processing method that encodes each genetic variant based on normalized mean phenotypic differences between diallelic genotype classes (AA, Aa, and aa). This approach more accurately reflects each variant’s true inheritance model, improving model precision while minimizing the costs associated with alternative encoding strategies. Results Through extensive benchmarking on SNPs simulated with both binary and continuous phenotypes, we demonstrate that PAGER accurately represents various inheritance patterns (including additive, dominant, recessive, and heterosis), achieves levels of statistical power that meet or exceed other encoding strategies, and attains computation speeds up to 55 times faster than a similar method, EDGE. We also apply PAGER to publicly available real-world data and identify a novel, relevant putative QTL associated with body mass index in rats (Rattus norvegicus) that is not detected with the additive model. Conclusions Overall, we show that PAGER is an efficient genotype encoding approach that can uncover sources of missing heritability and reveal novel insights in the study of complex traits while incurring minimal costs.
Published: 2024
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25. Rare variant contribution to the heritability of coronary artery disease

Author: Ghislain Rocheleau, Shoa L. Clarke, Gaëlle Auguste, Natalie R. Hasbani, Alanna C. Morrison, Adam S. Heath, Lawrence F. Bielak, Kruthika R. Iyer, Erica P. Young, Nathan O. Stitziel, Goo Jun, Cecelia Laurie, Jai G. Broome, Alyna T. Khan, Donna K. Arnett, Lewis C. Becker, Joshua C. Bis, Eric Boerwinkle, Donald W. Bowden, April P. Carson, Patrick T. Ellinor, Myriam Fornage, Nora Franceschini, Barry I. Freedman, Nancy L. Heard-Costa, Lifang Hou, Yii-Der Ida Chen, Eimear E. Kenny, Charles Kooperberg, Brian G. Kral, Ruth J. F. Loos, Sharon M. Lutz, JoAnn E. Manson, Lisa W. Martin, Braxton D. Mitchell, Rami Nassir, Nicholette D. Palmer, Wendy S. Post, Michael H. Preuss, Bruce M. Psaty, Laura M. Raffield, Elizabeth A. Regan, Stephen S. Rich, Jennifer A. Smith, Kent D. Taylor, Lisa R. Yanek, Kendra A. Young, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Austin T. Hilliard, Catherine Tcheandjieu, Patricia A. Peyser, Ramachandran S. Vasan, Jerome I. Rotter, Clint L. Miller, Themistocles L. Assimes, Paul S. de Vries, and Ron Do
Subjects: Science
Abstract: Abstract Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494 controls of European ancestry from the NHLBI TOPMed program. We estimate CAD heritability at 34.3% assuming a prevalence of 8.2%. Ultra-rare (minor allele frequency ≤ 0.1%) variants with low linkage disequilibrium (LD) score contribute ~50% of the heritability. We also investigate CAD heritability enrichment using a diverse set of functional annotations: i) constraint; ii) predicted protein-altering impact; iii) cis-regulatory elements from a cell-specific chromatin atlas of the human coronary; and iv) annotation principal components representing a wide range of functional processes. We observe marked enrichment of CAD heritability for most functional annotations. These results reveal the predominant role of ultra-rare variants in low LD on the heritability of CAD. Moreover, they highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.
Published: 2024
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26. Foraging distance distributions reveal how honeybee waggle dance recruitment varies with landscape

Author: Joseph Palmer, Ash E. Samuelson, Richard J. Gill, Ellouise Leadbeater, and Vincent A. A. Jansen
Subjects: Biology (General), QH301-705.5
Abstract: Abstract Honeybee (Apis mellifera) colonies use a unique collective foraging system, the waggle dance, to communicate and process the location of resources. Here, we present a means to quantify the effect of recruitment on colony forager allocation across the landscape by simply observing the waggle dance on the dancefloor. We show first, through a theoretical model, that recruitment leaves a characteristic imprint on the distance distribution of foraging sites that a colony visits, which varies according to the proportion of trips driven by individual search. Next, we fit this model to the real-world empirical distance distribution of forage sites visited by 20 honeybee colonies in urban and rural landscapes across South East England, obtained via dance decoding. We show that there is considerable variation in the use of dancing information in colony foraging, particularly in agri-rural landscapes. In our dataset, reliance on dancing increases as arable land gives way to built-up areas, suggesting that dancing may have the greatest impact on colony foraging in the complex and heterogeneous landscapes of forage-rich urban areas. Our model provides a tool to assess the relevance of this extraordinary behaviour across modern anthropogenic landscape types.
Published: 2024
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27. Improved definition of prior uncertainties in CO2 and CO fossil fuel fluxes and its impact on multi-species inversion with GEOS-Chem (v12.5)

Author: I. Super, T. Scarpelli, A. Droste, and P. I. Palmer
Subjects: Geology, QE1-996.5
Abstract: Monitoring, reporting, and verification frameworks for greenhouse gas emissions are being developed by countries across the world to keep track of progress towards national emission reduction targets. Data assimilation plays an important role in monitoring frameworks, combining different sources of information to achieve the best possible estimate of fossil fuel emissions and, as a consequence, better estimates for fluxes from the natural biosphere. Robust estimates for fossil fuel emissions rely on accurate estimates of uncertainties corresponding to different pieces of information. We describe prior uncertainties in CO2 and CO fossil fuel fluxes, paying special attention to spatial error correlations and the covariance structure between CO2 and CO. This represents the first time that prior uncertainties in CO2 and the important co-emitted trace gas CO are defined consistently, with error correlations included, which allows us to make use of the synergy between the two trace gases to better constrain CO2 fossil fuel fluxes. CO:CO2 error correlations differ by sector, depending on the diversity of sub-processes occurring within a sector, and also show a large range of values between pixels within the same sector. For example, for other stationary combustion, pixel correlation values range from 0.1 to 1.0, whereas for road transport, the correlation is mostly larger than 0.6. We illustrate the added value of our definition of prior uncertainties using closed-loop numerical experiments over mainland Europe and the UK, which isolate the influence of using error correlations between CO2 and CO and the influence of prescribing more detailed information about prior emission uncertainties. For the experiments, synthetic in situ observations are used, allowing us to validate the results against a “truth”. The “true” emissions are made by perturbing the prior emissions (from an emission inventory) according to the prescribed prior uncertainties. We find that using our realistic definition of prior uncertainties helps our data assimilation system to differentiate more easily between CO2 fluxes from biogenic and fossil fuel sources. Using improved prior emission uncertainties, we find fewer geographic regions with significant deviations from the prior compared to when using default prior uncertainties (32 vs. 80 grid cells of 0.25°×0.3125°, with an absolute difference of more than 1 kg s−1 between the prior and posterior), but these deviations from the prior almost consistently move closer to the prescribed true values, with 92 % showing an improvement, in contrast to the default prior uncertainties, where 61 % show an improvement. We also find that using CO provides additional information on CO2 fossil fuel fluxes, but this is only the case if the CO:CO2 error covariance structure is defined realistically. Using the default prior uncertainties, the CO2 fossil fuel fluxes move farther away from the truth in many geographical regions (with 50 % showing an improvement compared to 94 % when advanced prior uncertainties are used). With the default uncertainties, the maximum deviation of fossil fuel CO2 from the prescribed truth is about 7 % in both the prior and posterior results. With the advanced uncertainties, this is reduced to 3 % in the posterior results.
Published: 2024
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28. Phenotypic evidence of deltamethrin resistance and identification of selective sweeps in Anopheles mosquitoes on the Bijagós Archipelago, Guinea-Bissau

Author: Sophie Moss, Robert T. Jones, Elizabeth Pretorius, Eunice Teixeira da Silva, Matthew Higgins, Mojca Kristan, Holly Acford-Palmer, Emma L. Collins, Amabelia Rodrigues, Sanjeev Krishna, Taane G. Clark, Anna Last, and Susana Campino
Subjects: Medicine, Science
Abstract: Abstract Vector control in the Bijagós Archipelago of Guinea-Bissau currently relies on pyrethroid insecticide-treated nets. However, data on insecticide resistance in Guinea-Bissau is limited. This study identified deltamethrin resistance in the Anopheles gambiae sensu lato complex on Bubaque island using WHO tube tests in November 2022. Whole genome sequencing of An. gambiae sensu stricto mosquitoes identified six single nucleotide polymorphisms (SNPs) previously associated with, or putatively associated with, insecticide resistance: T791M, L995F, N1570Y, A1746S and P1874L in the vgsc gene, and L119V in the gste2 gene. Twenty additional non-synonymous SNPs were identified in insecticide-resistance associated genes. Four of these SNPs were present at frequencies over 5% in the population: T154S, I126F and G26S in the vgsc gene and A65S in ace1. Genome wide selection scans using Garud’s H12 statistic identified two selective sweeps: one in chromosome X and one in chromosome 2R. Both selective sweeps overlap with metabolic genes previously associated with insecticide resistance, including cyp9k1 and the cyp6aa/cyp6p gene cluster. This study presents the first phenotypic testing for deltamethrin resistance and the first whole genome sequence data for Anopheles gambiae mosquitoes from the Bijagós, contributing data of significance for vector control policy in this region.
Published: 2024
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29. Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height

Author: Gareth Hawkes, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, April P. Carson, Nathalie Chami, Yii-Der Ida Chen, Mina K. Chung, Joanne E. Curran, Dawood Darbar, Patrick T. Ellinor, Myrian Fornage, Victor R. Gordeuk, Xiuqing Guo, Jiang He, Chii-Min Hwu, Rita R. Kalyani, Robert Kaplan, Sharon L. R. Kardia, Charles Kooperberg, Ruth J. F. Loos, Steven A. Lubitz, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Braxton D. Mitchell, Joanne M. Murabito, Nicholette D. Palmer, Bruce M. Psaty, Susan Redline, M. Benjamin Shoemaker, Edwin K. Silverman, Marilyn J. Telen, Scott T. Weiss, Lisa R. Yanek, Hufeng Zhou, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ching-Ti Liu, Kari E. North, Anne E. Justice, Jonathan M. Locke, Nick Owens, Anna Murray, Kashyap Patel, Timothy M. Frayling, Caroline F. Wright, Andrew R. Wood, Xihong Lin, Alisa Manning, and Michael N. Weedon
Subjects: Science
Abstract: Abstract The role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N = 200,003), TOPMed (N = 87,652) and All of Us (N = 45,445). We performed rare (
Published: 2024
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30. Taking the Next Step in Exploring the Literary Digest 1936 Poll

Author: Beth Chance, Andrew Kerr, and Jett Palmer
Subjects: Bias, Data cleaning, Data validation, Post-stratification, Probabilities. Mathematical statistics, QA273-280, Special aspects of education, LC8-6691
Abstract: While many instructors are aware of the Literary Digest 1936 poll as an example of biased sampling methods, this article details potential further explorations for the Digest’s 1924–1936 quadrennial U.S. presidential election polls. Potential activities range from lessons in data acquisition, cleaning, and validation, to basic data literacy and visualization skills, to exploring one or more methods of adjustment to account for bias based on information collected at that time. Students can also compare how those methods would have performed. One option could be to give introductory students a first look at the idea of “sampling adjustment” and how this principle can be used to account for difficulties in modern polling, but the context is rich in other opportunities that can be discussed at various times in the course or in more advanced sampling courses. Supplementary materials for this article are available online.
Published: 2024
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31. Posterior Vitreous Detachment and Risk of Neovascular Glaucoma in Eyes with Prior Retinal Vascular Occlusions

Author: Laura D. Palmer, Jared D. Peterson, Joni K. Evans, Mark H. Nelson, Sanjay Asrani, and Atalie C. Thompson
Subjects: Neovascular glaucoma, Posterior vitreous detachment, Retinal vascular occlusion, Ophthalmology, RE1-994
Abstract: Abstract Introduction To investigate the impact of posterior vitreous detachment (PVD) on the risk of developing neovascular glaucoma (NVG) in eyes with occlusions of the retinal artery (RAO) or retinal vein (RVO). Methods Single-center retrospective case-control study of adults with a history of RVO/RAO. Cases (N = 101) who developed NVG were age and sex matched 1:2 to controls who did not develop NVG (N = 202). Multivariable logistic regression was used to estimate the association between history of PVD and risk of NVG while controlling for other related demographic or clinical factors. Results In initial bivariate analyses, there was no difference in risk of NVG based on eye, lens status, hypertension, history of panretinal photocoagulation (PRP), or retinal surgery (all p > 0.10), a borderline difference based on diabetic retinopathy (DR) (p = 0.06) and prior anti-vascular endothelial growth factor (anti-VEGF) treatment (p = 0.08), and a significant difference based on race/ethnicity, type of vascular event, and PVD status (all p
Published: 2024
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32. Whole genome sequence analysis of population structure and insecticide resistance markers in Anopheles melas from the Bijagós Archipelago, Guinea-Bissau

Author: Sophie Moss, Elizabeth Pretorius, Sainey Ceesay, Eunice Teixeira da Silva, Harry Hutchins, Mamadou Ousmane Ndiath, Holly Acford-Palmer, Emma L. Collins, Matthew Higgins, Jody Phelan, Robert T. Jones, Hristina Vasileva, Amabelia Rodrigues, Sanjeev Krishna, Taane G. Clark, Anna Last, and Susana Campino
Subjects: Anopheles melas, Whole-genome sequencing, Guinea-Bissau, Population structure, Insecticide resistance, Malaria, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Anopheles melas is an understudied malaria vector with a potential role in malaria transmission on the Bijagós Archipelago of Guinea-Bissau. This study presents the first whole-genome sequencing and population genetic analysis for this species from the Bijagós. To our knowledge, this also represents the largest population genetic analysis using WGS data from non-pooled An. melas mosquitoes. Methods WGS was conducted for 30 individual An. melas collected during the peak malaria transmission season in 2019 from six different islands on the Bijagós Archipelago. Bioinformatics tools were used to investigate the population structure and prevalence of insecticide resistance markers in this mosquito population. Results Insecticide resistance mutations associated with pyrethroid resistance in Anopheles gambiae s.s. from the Bijagós were absent in the An. melas population, and no signatures of selective sweeps were identified in insecticide resistance-associated genes. Analysis of structural variants identified a large duplication encompassing the cytochrome-P450 gene cyp9k1. Phylogenetic analysis using publicly available mitochondrial genomes indicated that An. melas from the Bijagós split into two phylogenetic groups because of differentiation on the mitochondrial genome attributed to the cytochrome C oxidase subunits COX I and COX II and the NADH dehydrogenase subunits 1, 4, 4L and 5. Conclusions This study identified an absence of insecticide-resistant SNPs common to An. gambiae in the An. melas population, but did identify structural variation over insecticide resistance-associated genes. Furthermore, this study presents novel insights into the population structure of this malaria vector using WGS analysis. Additional studies are required to further understand the role of this vector in malaria transmission. Graphical abstract
Published: 2024
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33. Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV using leptonic W boson decays

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, B. Lopes Da Costa, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, D. Laroze, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Y. Li, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. 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Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, S. Norberg, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, M. Safdari, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, P. Chang, V. Cherepanov, R. D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, S. Rosenzweig, Y. Takahashi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, V. Hagopian, R. Hashmi, R. S. Kim, T. Kolberg, G. Martinez, H. Prosper, P. R. Prova, M. Wulansatiti, R. Yohay, B. Alsufyani, M. M. Baarmand, S. Butalla, S. Das, T. Elkafrawy, M. Hohlmann, E. Yanes, M. R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C. E. Gerber, M. Hawksworth, A. Hingrajiya, D. J. Hofman, J. h. Lee, D. S. Lemos, A. H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, E. Prifti, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, M. A. Wadud, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, S. Arteaga Escatel, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, J. Natoli, D. Roy, G. Sorrentino, A. Baden, A. Belloni, J. Bistany-riebman, Y. M. Chen, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, B. Kronheim, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M. M. Paranjpe, E. Popova, A. Shevelev, L. Wang, J. Bendavid, I. A. Cali, P. c. Chou, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mcginn, A. Novak, C. Paus, C. Roland, G. Roland, S. Rothman, G. S. F. Stephans, B. Wyslouch, T. J. Yang, B. Crossman, B. M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, M. Revering, R. Rusack, R. Saradhy, N. Strobbe, K. Bloom, D. R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J. E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, H. w. Hsia, I. Iashvili, A. Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Malik, A. S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A. W. Jung, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, A. Wildridge, W. Xie, Y. Yao, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, I. Krommydas, W. Li, J. Lin, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, R. Taus, B. Chiarito, J. P. Chou, S. V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A. G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A. R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, H. Chung, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, G. Vorotnikov, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Beyond Standard Model, Hadron-Hadron Scattering, Particle and Resonance Production, Photon Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for a new charged particle X with mass between 0.3 and 2.0 TeV decaying to a W boson and a photon is presented, using proton-proton collision data at a center-of-mass energy of 13 TeV, collected by the CMS experiment and corresponding to an integrated luminosity of 138 fb −1. Particle X has electric charge ±1 and is assumed to have spin 0. The search is performed using the electron and muon decays of the W boson. No significant excess above the predicted background is observed. The upper limit at 95% confidence level on the product of the production cross section of the X and its branching fraction to a W boson and a photon is found to be 94 (137) fb for a 0.3 TeV resonance and 0.75 (0.81) fb for a 2.0 TeV resonance, for an X width-to-mass ratio of 0.01% (5%). This search presents the most stringent constraints to date on the existence of such resonances across the probed mass range. A statistical combination with an earlier study based on the hadronic decay mode of the W boson is also performed, and the upper limit at 95% confidence level for a 2.0 TeV resonance is reduced to 0.50 (0.63) fb for an X width-to-mass ratio of 0.01% (5%).
Published: 2024
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34. The subjective wellbeing of people living with Multiple Sclerosis in Australia: insights from the Personal Wellbeing Index

Author: Glen J. Henson, Ingrid van der Mei, Bruce V. Taylor, Suzi B. Claflin, Andrew J. Palmer, Julie A. Campbell, and Gang Chen
Subjects: Computer applications to medicine. Medical informatics, R858-859.7
Abstract: Abstract Objectives Subjective wellbeing has been defined as an individual’s personal appraisal of their quality of life. Subjective wellbeing is associated with positive health behaviours and improved coping abilities. This study aimed to investigate the subjective wellbeing of people living with multiple sclerosis (MS), using the novel Personal Wellbeing Index, and make comparisons with the general population. Methods Cross-sectional data was obtained from the Australian Multiple Sclerosis Longitudinal Study and the How Is Your Life Australian general population study in August-October 2020. Subjective wellbeing was measured as life satisfaction using the Personal Wellbeing Index. This instrument measures life satisfaction globally and in seven life domains, allowing the importance of domain-specific life satisfaction to be explored. Descriptive and multivariable regression analyses were conducted. Results One thousand six hundred eighty-three MS and 1,021 general population participants entered the study (mean age 52.4 and 58.6; female 79.9% and 52.4%, respectively). For people living with MS the most important life domains were standard of living and achieving in life. The domain of personal health was more influential for people living with MS (p
Published: 2024
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35. Design and baseline characteristics of the ILD-PRO registry in patients with progressive pulmonary fibrosis

Author: L Jason Lobo, Yi Liu, Peide Li, Murali Ramaswamy, Aparna C Swaminathan, Srihari Veeraraghavan, Yanni Fan, Megan L Neely, Scott M Palmer, Amy L Olson, and on behalf of the ILD-PRO Registry investigators
Subjects: Clinical trial, Disease progression, Interstitial lung disease, Pulmonary fibrosis, Diseases of the respiratory system, RC705-779
Abstract: Abstract Background To assess the characteristics of patients enrolled in the ILD-PRO Registry. Methods The ILD-PRO Registry is a multicentre US registry of patients with progressive pulmonary fibrosis. This registry is enrolling patients with an interstitial lung disease (ILD) other than idiopathic pulmonary fibrosis who have reticular abnormality and traction bronchiectasis on HRCT, and who meet criteria for ILD progression within the prior 24 months. Patient characteristics were analysed based on the number of patients with available data. Results Of the first 491 patients enrolled, the majority were white (75.4%) and female (60.6%); 47.4% had a history of smoking. Reported ILDs were autoimmune disease-associated ILDs (47.2%), hypersensitivity pneumonitis (17.5%), idiopathic non-specific interstitial pneumonia (9.1%), interstitial pneumonia with autoimmune features (8.9%), unclassifiable ILD (7.6%), other ILDs (9.7%). At enrolment, median (Q1, Q3) FVC % predicted was 62.2 (49.4, 72.4) and DLco % predicted was 39.2 (30.2, 49.2). Median (Q1, Q3) total score on the St. George’s Respiratory Questionnaire was 50.8 (35.9, 64.7). The most common comorbidities were gastroesophageal reflux disease (61.1%) and sleep apnoea (29.6%). Overall, 64.5% of patients were receiving immunosuppressive or cytotoxic therapy, 61.1% proton-pump inhibitors, 53.2% oral steroids, 19.8% nintedanib and 3.6% pirfenidone. Conclusions Patients enrolled into the ILD-PRO Registry have a variety of ILD diagnoses, marked impairment in lung function and health-related quality of life, and high medication use. Longitudinal data from this registry will further our knowledge of the course of progressive pulmonary fibrosis. Trial Registration ClinicalTrials.gov, NCT01915511; registered August 5, 2013.
Published: 2024
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36. Assessing and correcting neighborhood socioeconomic spatial sampling biases in citizen science mosquito data collection

Author: Álvaro Padilla-Pozo, Frederic Bartumeus, Tomás Montalvo, Isis Sanpera-Calbet, Andrea Valsecchi, and John R. B. Palmer
Subjects: Mosquito-borne diseases, Vector control, Vector surveillance, Aedes albopictus, Citizen science, Social inequality, Medicine, Science
Abstract: Abstract Climatic, ecological, and socioeconomic factors are facilitating the spread of mosquito-borne diseases, heightening the importance of vector surveillance and control. Citizen science is proving to be an effective tool to track mosquito populations, but methods are needed to detect and account for small scale sampling biases in citizen science surveillance. In this article we combine two types of traditional mosquito surveillance records with data from the Mosquito Alert citizen science system to explore the ways in which the socioeconomic characteristics of urban neighborhoods result in sampling biases in citizen scientists’ mosquito reports, while also shaping the spatial distribution of mosquito populations themselves. We use Barcelona, Spain, as an example, and focus on Aedes albopictus, an invasive vector species of concern worldwide. Our results suggest citizen scientists’ sampling effort is focused more in Barcelona’s lower and middle income census tracts than in its higher income ones, whereas Ae. albopictus populations are concentrated in the city’s upper-middle income tracts. High resolution estimates of the spatial distribution of Ae. albopictus risk can be improved by controlling for citizen scientists’ sampling effort, making it possible to provide better insights for efficiently targeting control efforts. Our methodology can be replicated in other cities faced with vector mosquitoes to improve public health responses to mosquito-borne diseases, which impose massive burdens on communities worldwide.
Published: 2024
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37. Greenhouse gas column observations from a portable spectrometer in Uganda

Author: N. Humpage, H. Boesch, W. Okello, J. Chen, F. Dietrich, M. F. Lunt, L. Feng, P. I. Palmer, and F. Hase
Subjects: Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract: The extensive terrestrial ecosystems of tropical Africa are a significant store of carbon and play a key but uncertain role in the atmospheric budgets of carbon dioxide and methane. As ground-based observations in the tropics are scarce compared with other parts of the world, recent studies have instead made use of satellite observations assimilated into atmospheric chemistry and transport models to conclude that methane emissions from this geographical region have increased since 2010 as a result of increased wetland extent, accounting for up to a third of global methane growth, and that the tropical Africa region dominates net carbon emission across the tropics. These studies critically rely on the accuracy of satellite datasets, such as those from the Orbiting Carbon Observatory-2 (OCO-2), the Greenhouse gases Observing SATellite (GOSAT), and the Sentinel-5 Precursor TROPOspheric Monitoring Instrument (TROPOMI), along with results from atmospheric transport models, over a geographical region where there are little independent data to test the robustness of published results. In this paper we present the first ground-based observations of greenhouse gas column concentrations over East Africa, obtained using a portable Bruker EM27/SUN Fourier transform infrared (FTIR) spectrometer during a deployment covering the first few months of 2020 in Jinja, Uganda. We operated the instrument near autonomously by way of an automated weatherproof enclosure and observed total atmospheric column concentrations of the greenhouse gases carbon dioxide and methane, as well as carbon monoxide, a useful proxy for emissions from incomplete combustion processes in the region. We discuss the performance of the combined enclosure and spectrometer system that we deployed in Jinja to obtain these data and show comparisons of our ground-based observations with satellite datasets from OCO-2 and Orbiting Carbon Observatory-3 (OCO-3) for carbon dioxide and TROPOMI for methane and carbon monoxide, whilst also comparing our results with concentration data from the GEOS-Chem and Copernicus Atmosphere Monitoring Service (CAMS) atmospheric inversions that provide a means of increasing spatial and temporal coverage where satellite data are not available. For our measurement period, we find mean differences in XCO2 between OCO-2 and the EM27/SUN of −0.29 % and between OCO-3 and the EM27/SUN of −0.28 %. In the case of TROPOMI, the mean difference in XCH4 that we find between TROPOMI and the EM27/SUN is −0.44 %, whilst for XCO the mean difference is −5.65 %. In each of these cases, the mean difference observed between the satellite and ground-based column concentrations is either close to or within the precision and accuracy requirements for the respective missions. With regard to the model and reanalysis comparisons with the EM27/SUN column concentrations, we see mean differences from the EM27/SUN of a global GEOS-Chem inversion for XCO2 of −0.08 %, a regional high-resolution GEOS-Chem inversion for XCH4 of −0.22 %, and the CAMS global reanalysis for XCO of −9.79 %. Our results demonstrate the value of ground-based observations of total column concentrations and show that the combined EM27/SUN and enclosure system employed would be suitable for acquisition of the longer-term observations needed to rigorously evaluate satellite observations and model and reanalysis calculations over tropical Africa.
Published: 2024
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38. Association Between Alpha-1 Adrenoreceptor Antagonist Use and Cognitive Impairment: A Systematic Review

Author: Ryan Kingsley, Sara Tyree, Dhairya Jarsania, Christopher Edquist, Allyson Palmer, Dana Gerberi, Robert Wilfahrt, and Sandeep Pagali
Subjects: alpha blocker, alzheimer disease, cognitive impairment, dementia, systematic review, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Alpha-1 adrenergic receptor (α1-AR) antagonists are commonly used for management of benign prostatic hyperplasia or hypertension. Some studies have shown a potential link between α1-AR antagonist use and cognitive impairment. Given the conflicting data surrounding α1-AR antagonists association with cognitive dysfunction, we aim to systematically review the association of cognitive dysfunction with α1-AR antagonist use to aid clinician decision both with medication initiation and continuation. A systematic review was performed following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We searched Ovid Cochrane, Ovid Embase, Ovid MEDLINE, Scopus, and Web of Science on March 7, 2023, with an update run on January 22, 2024. The primary outcome was cognitive dysfunction. We used Cochrane risk of bias for randomized controlled trials (RCTs) and MINORS (Methodological Index for Non-Randomized Studies) criteria for non-RCTs to evaluate study quality. This study was registered with PROSPERO (CRD42024505751). We identified 7 studies for our systematic review (3 RCTs, 4 non-RCTs). Tamsulosin was the most studied medication (6 of 7 studies). Tamsulosin was associated with no cognitive dysfunction in 2 RCTs, increased risk for dementia in 2 non-RCTs, no change in cognition in 1 non-RCT, and decreased risk for dementia in 1 non-RCT. Among 3 non-RCTs analyzing alfuzosin, it was associated with decreased risk of or no association with dementia in 2 studies and increased risk for dementia in 1 study. Doxazosin, prazosin, and terazosin were neutral or showed a negative risk for dementia. Our systematic review did not show a convincing causal association between α1-AR antagonists, including tamsulosin, and cognitive dysfunction. Considering the existing literature, it is appropriate to use α1-AR antagonists without concern for cognitive dysfunction. Future research, through robust study designs considering the multifactorial nature of cognitive dysfunction, is required to further evaluate this association.
Published: 2024
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39. Verifying national inventory-based combustion emissions of CO2 across the UK and mainland Europe using satellite observations of atmospheric CO and CO2

Author: T. R. Scarpelli, P. I. Palmer, M. Lunt, I. Super, and A. Droste
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Under the Paris Agreement, countries report their anthropogenic greenhouse gas emissions in national inventories, which are used to track progress towards mitigation goals, but they must be independently verified. Atmospheric observations of CO2, interpreted using inverse methods, can potentially provide that verification. Conventional CO2 inverse methods infer natural CO2 fluxes by subtracting a priori estimates of fuel combustion from the a posteriori net CO2 fluxes, assuming that a priori knowledge for combustion emissions is better than for natural fluxes. We describe an inverse method that uses measurements of CO2 and carbon monoxide (CO), a trace gas that is co-emitted with CO2 during combustion, to report self-consistent combustion emissions and natural fluxes of CO2. We use an ensemble Kalman filter and the GEOS-Chem atmospheric transport model to explore how satellite observations of CO and CO2 collected by the TROPOspheric Monitoring Instrument (TROPOMI) and Orbiting Carbon Observatory-2 (OCO-2), respectively, can improve understanding of combustion emissions and natural CO2 fluxes across the UK and mainland Europe in 2018–2021. We assess the value of using satellite observations of CO2, with and without CO, above what is already available from the in situ network. Using CO2 satellite observations leads to small corrections to a priori emissions that are inconsistent with in situ observations, due partly to the insensitivity of the atmospheric CO2 column to CO2 emission changes. When we introduce satellite CO observations, we find better agreement with our in situ inversion and a better model fit to atmospheric CO2 observations. Our regional mean a posteriori combustion CO2 emission ranges from 4.6–5.0 Gt a−1 (1.5 %–2.4 % relative standard deviation), with all inversions reporting an overestimate for Germany's wintertime emissions. Our national a posteriori CO2 combustion emissions are highly dependent on the assumed relationship between CO2 and CO uncertainties, as expected. Generally, we find better results when we use grid-scale-based a priori CO2:CO uncertainty estimates rather than a fixed relationship between the two species.
Published: 2024
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40. Competition Creates Deep Space Cuisine

Author: Chris Palmer
Subjects: Engineering (General). Civil engineering (General), TA1-2040
Published: 2024
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41. Faecal microbiota and cytokine profiles of rural Cambodian infants linked to diet and diarrhoeal episodes

Author: Matthew J. Dalby, Raymond Kiu, Iliana R. Serghiou, Asuka Miyazaki, Holly Acford-Palmer, Rathavy Tung, Shabhonam Caim, Sarah Phillips, Magdalena Kujawska, Mitsuaki Matsui, Azusa Iwamoto, Bunsreng Taking, Sharon E. Cox, and Lindsay J. Hall
Subjects: Microbial ecology, QR100-130
Abstract: Abstract The gut microbiota of infants in low- to middle-income countries is underrepresented in microbiome research. This study explored the faecal microbiota composition and faecal cytokine profiles in a cohort of infants in a rural province of Cambodia and investigated the impact of sample storage conditions and infant environment on microbiota composition. Faecal samples collected at three time points from 32 infants were analysed for microbiota composition using 16S rRNA amplicon sequencing and concentrations of faecal cytokines. Faecal bacterial isolates were subjected to whole genome sequencing and genomic analysis. We compared the effects of two sample collection methods due to the challenges of faecal sample collection in a rural location. Storage of faecal samples in a DNA preservation solution preserved Bacteroides abundance. Microbiota analysis of preserved samples showed that Bifidobacterium was the most abundant genus with Bifidobacterium longum the most abundant species, with higher abundance in breast-fed infants. Most infants had detectable pathogenic taxa, with Shigella and Klebsiella more abundant in infants with recent diarrhoeal illness. Neither antibiotics nor infant growth were associated with gut microbiota composition. Genomic analysis of isolates showed gene clusters encoding the ability to digest human milk oligosaccharides in B. longum and B. breve isolates. Antibiotic-resistant genes were present in both potentially pathogenic species and in Bifidobacterium. Faecal concentrations of Interlukin-1alpha and vascular endothelial growth factor were higher in breast-fed infants. This study provides insights into an underrepresented population of rural Cambodian infants, showing pathogen exposure and breastfeeding impact gut microbiota composition and faecal immune profiles.
Published: 2024
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42. Evaluation of research co-design in health: a systematic overview of reviews and development of a framework

Author: Sanne Peters, Lisa Guccione, Jill Francis, Stephanie Best, Emma Tavender, Janet Curran, Katie Davies, Stephanie Rowe, Victoria J. Palmer, and Marlena Klaic
Subjects: Research co-design, Evaluation, Stakeholder involvement, End-user engagement, Consumer participation, Outcome measures, Medicine (General), R5-920
Abstract: Abstract Background Co-design with consumers and healthcare professionals is widely used in applied health research. While this approach appears to be ethically the right thing to do, a rigorous evaluation of its process and impact is frequently missing. Evaluation of research co-design is important to identify areas of improvement in the methods and processes, as well as to determine whether research co-design leads to better outcomes. We aimed to build on current literature to develop a framework to assist researchers with the evaluation of co-design processes and impacts. Methods A multifaceted, iterative approach, including three steps, was undertaken to develop a Co-design Evaluation Framework: 1) A systematic overview of reviews; 2) Stakeholder panel meetings to discuss and debate findings from the overview of reviews and 3) Consensus meeting with stakeholder panel. The systematic overview of reviews included relevant papers published between 2000 and 2022. OVID (Medline, Embase, PsycINFO), EBSCOhost (Cinahl) and the Cochrane Database of Systematic reviews were searched for papers that reported co-design evaluation or outcomes in health research. Extracted data was inductively analysed and evaluation themes were identified. Review findings were presented to a stakeholder panel, including consumers, healthcare professionals and researchers, to interpret and critique. A consensus meeting, including a nominal group technique, was applied to agree upon the Co-design Evaluation Framework. Results A total of 51 reviews were included in the systematic overview of reviews. Fifteen evaluation themes were identified and grouped into the following seven clusters: People (within co-design group), group processes, research processes, co-design context, people (outside co-design group), system and sustainment. If evaluation methods were mentioned, they mainly included qualitative data, informal consumer feedback and researchers’ reflections. The Co-Design Evaluation Framework used a tree metaphor to represent the processes and people in the co-design group (below-ground), underpinning system- and people-level outcomes beyond the co-design group (above-ground). To evaluate research co-design, researchers may wish to consider any or all components in the tree. Conclusions The Co-Design Evaluation Framework has been collaboratively developed with various stakeholders to be used prospectively (planning for evaluation), concurrently (making adjustments during the co-design process) and retrospectively (reviewing past co-design efforts to inform future activities).
Published: 2024
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43. Overview and recommendations for research on plants and microbes in regolith-based agriculture

Author: Laura E. Fackrell, Samson Humphrey, Rafael Loureiro, Andrew G. Palmer, and Jared Long-Fox
Subjects: Agriculture (General), S1-972, Ecology, QH540-549.5
Abstract: Abstract The domestication of agriculture is widely recognized as one of the most crucial technological adaptations for the transition of humanity from hunter-and-gatherer groups into early city-states and ultimately, complex civilizations. As humankind sets forth to permanently establish itself on the Moon and use it as a testing ground to colonize other worlds, like Mars, agriculture will again play a pivotal role. In this case, the development of sustainable crop production systems capable of succeeding in these harsh environments becomes vital to the success of our star-faring journey. Over decades, studies varying in species and approaches have been conducted in microgravity, testing the limits of plants and various growth systems, to better understand how Earth-based agriculture could be translated into environmental conditions and therefore evolutionary pressures beyond what life on our planet has known. While we have passed several significant milestones, we are still far from the goal of a sustainable agricultural system beyond our planet Regolith-based agriculture (RBA) should be a component of sustainable agriculture solutions beyond Earth, one which can also provide insight into plant growth in poor soils across our own world. However, RBA studies are in their infancy and, like any other new field, need an established set of parameters to be followed by the RBA community so the generated data can be standardized and validated. Here, we provide an extensive multi-disciplinary review of the state of RBA, outline important knowledge gaps, and propose a set of standardized methods and benchmarks for regolith simulant development and selection as well as plant, microbe, and plant-microbe interaction studies conducted in lunar and Martian regolith. Our goal is to spur dialog within the RBA community on proper regolith simulant selection, experimental design, and reporting. Our methods are divided into complexity tiers, providing a clear path for even the simplest experiments to contribute to the bulk of the knowledge that will shape the future of RBA science and see it mature as an integrated part of sustainable off-world agriculture.
Published: 2024
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44. Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma

Author: Satish kumar Reddy Noonepalle, Maria Gracia-Hernandez, Nima Aghdam, Michael Berrigan, Hawa Coulibaly, Xintang Li, Christian Zevallos-Delgado, Andrew Pletcher, Bryan Weselman, Erica Palmer, Tessa Knox, Eduardo Sotomayor, Katherine B. Chiappinelli, Duncan Wardrop, Anelia Horvath, Brett A. Shook, Norman Lee, Anatoly Dritschilo, Rohan Fernandes, Karthik Musunuri, Maho Shibata, and Alejandro Villagra
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Macrophage-based cell therapies have shown modest success in clinical trials, which can be attributed to their phenotypic plasticity, where transplanted macrophages get reprogrammed towards a pro-tumor phenotype. In most tumor types, including melanoma, the balance between antitumor M1-like and tumor-promoting M2-like macrophages is critical in defining the local immune response with a higher M1/M2 ratio favoring antitumor immunity. Therefore, designing novel strategies to increase the M1/M2 ratio in the TME has high clinical significance and benefits macrophage-based cell therapies. Methods In this study, we reprogrammed antitumor and proinflammatory macrophages ex-vivo with HDAC6 inhibitors (HDAC6i). We administered the reprogrammed macrophages intratumorally as an adoptive cell therapy (ACT) in the syngeneic SM1 murine melanoma model and patient-derived xenograft bearing NSG-SGM3 humanized mouse models. We phenotyped the tumor-infiltrated immune cells by flow cytometry and histological analysis of tumor sections for macrophage markers. We performed bulk RNA-seq profiling of murine bone marrow-derived macrophages treated with vehicle or HDAC6i and single-cell RNA-seq profiling of SM1 tumor-infiltrated immune cells to determine the effect of intratumor macrophage ACT on the tumor microenvironment (TME). We further analyzed the single-cell data to identify key cell-cell interactions and trajectory analysis to determine the fate of tumor-associated macrophages post-ACT. Results Macrophage ACT resulted in diminished tumor growth in both mouse models. We also demonstrated that HDAC6 inhibition in macrophages suppressed the polarization toward tumor-promoting phenotype by attenuating STAT3-mediated M2 reprogramming. Two weeks post-transplantation, ACT macrophages were viable, and inhibition of HDAC6 rendered intratumor transplanted M1 macrophages resistant to repolarization towards protumor M2 phenotype in-vivo. Further characterization of tumors by flow cytometry, single-cell transcriptomics, and single-cell secretome analyses revealed a significant enrichment of antitumor M1-like macrophages, resulting in increased M1/M2 ratio and infiltration of CD8 effector T-cells. Computational analysis of single-cell RNA-seq data for cell-cell interactions and trajectory analyses indicated activation of monocytes and T-cells in the TME. Conclusions In summary, for the first time, we demonstrated the potential of reprogramming macrophages ex-vivo with HDAC6 inhibitors as a viable macrophage cell therapy to treat solid tumors.
Published: 2024
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45. In human–machine trust, humans rely on a simple averaging strategy

Author: Jonathon Love, Quentin F. Gronau, Gemma Palmer, Ami Eidels, and Scott D. Brown
Subjects: Human–machine team, Trust, Automation, Judge–advisor system, Consciousness. Cognition, BF309-499
Abstract: Abstract With the growing role of artificial intelligence (AI) in our lives, attention is increasingly turning to the way that humans and AI work together. A key aspect of human–AI collaboration is how people integrate judgements or recommendations from machine agents, when they differ from their own judgements. We investigated trust in human–machine teaming using a perceptual judgement task based on the judge–advisor system. Participants ( $$n=89$$ n = 89 ) estimated a perceptual quantity, then received a recommendation from a machine agent. The participants then made a second response which combined their first estimate and the machine’s recommendation. The degree to which participants shifted their second response in the direction of the recommendations provided a measure of their trust in the machine agent. We analysed the role of advice distance in people’s willingness to change their judgements. When a recommendation falls a long way from their initial judgement, do people come to doubt their own judgement, trusting the recommendation more, or do they doubt the machine agent, trusting the recommendation less? We found that although some participants exhibited these behaviours, the most common response was neither of these tendencies, and a simple model based on averaging accounted best for participants’ trust behaviour. We discuss implications for theories of trust, and human–machine teaming.
Published: 2024
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46. Old MacDonald Has a New Animal on the Farm—Insects

Author: Chris Palmer
Subjects: Engineering (General). Civil engineering (General), TA1-2040
Published: 2024
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47. Innovations Not Enough—Yet—to Make Headset Market an Actual Reality

Author: Chris Palmer
Subjects: Engineering (General). Civil engineering (General), TA1-2040
Published: 2024
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48. Cost-effectiveness of nonavalent HPV vaccination in the Netherlands

Author: Cody Palmer, Christiaan Dolk, Ugne Sabale, Wei Wang, and Kunal Saxena
Subjects: Cost-effectiveness modeling, health economics, HPV vaccination, human papilloma virus, netherlands, Internal medicine, RC31-1245
Abstract: ABSTRACTBackground A bivalent human papillomavirus vaccine (2vHPV) is currently used in the Netherlands; a nonavalent vaccine (9vHPV) is also licensed.Research design and methods We compared the public health and economic benefits of 2vHPV- and 9vHPV-based vaccination strategies in the Netherlands over 100 years using a validated deterministic dynamic transmission metapopulation model.Results Compared to 2vHPV, the 9vHPV strategy averted an additional 3,245 cases of and 825 deaths from 9vHPV-strain-attributable cancers, 4,247 cases of and 190 deaths from recurrent respiratory papillomatosis (RRP), and 1,009,637 cases of anogenital warts (AGWs), with an incremental cost-effectiveness ratio (ICER) of €4,975 per quality-adjusted life year (QALY) gained. The ICER increased in a scenario with increased HPV vaccination coverage rates and was relatively robust to one-way deterministic sensitivity analyses, with variation in the disease utility parameter having the most impact. When catch-up vaccination for individuals ≤26 years of age was added to the model, vaccinating with 9vHPV averted additional cancers and AGWs compared to 2vHPV vaccination.Conclusion Our analyses predict that transitioning from a 2vHPV- to a 9vHPV-based vaccination strategy would be cost-effective in the Netherlands.
Published: 2024
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49. Cost of opioid intravenous patient-controlled analgesia: results from a hospital database analysis and literature assessment

Author: Palmer P, Ji X, and Stephens J
Subjects: Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract: Pamela Palmer,1 Xiang Ji,2 Jennifer Stephens21AcelRx Pharmaceuticals, Inc., Redwood City, CA, 2Pharmerit International, Bethesda, MD, USABackground: Intravenous patient-controlled analgesia (PCA) equipment and opioid cost analyses on specific procedures are lacking. This study estimates the intravenous PCA hospital cost for the first 48 postoperative hours for three inpatient surgeries.Methods: Descriptive analyses using the Premier database (2010–2012) of more than 500 US hospitals were conducted on cost (direct acquisition and indirect cost for the hospital, such as overhead, labor, pharmacy services) of intravenous PCA after total knee/hip arthroplasty (TKA/THA) or open abdominal surgery. Weighted average cost of equipment and opioid drug and the literature-based cost of adverse events and complications were aggregated for total costs.Results: Of 11,805,513 patients, 272,443 (2.3%), 139,275 (1.2%), and 195,062 (1.7%) had TKA, THA, and abdominal surgery, respectively, with approximately 20% of orthopedic and 29% of abdominal patients having specific intravenous PCA database cost entries. Morphine (57%) and hydromorphone (44%) were the most frequently used PCA drugs, with a mean cost per 30 cc syringe of $16 (30 mg) and $21 (6 mg), respectively. The mean number of syringes used for morphine and hydromorphone in the first 48 hours were 1.9 and 3.2 (TKA), 2.0 and 4.2 (THA), and 2.5 and 3.9 (abdominal surgery), respectively. Average costs of PCA pump, intravenous tubing set, and drug ranged from $46 to $48, from $20 to $22, and from $33 to $46, respectively. Pump, tubing, and saline required to maintain patency of the intravenous PCA catheter over 48 hours ranged from $9 to $13, from $8 to $9, and from $20 to $22, respectively. Supplemental non-PCA opioid use ranged from $56 for THA to $87 for abdominal surgery. Aggregated mean intravenous PCA equipment and opioid cost per patient were $196 (THA), $204 (TKA), and $243 (abdominal surgery). Total costs, including for adverse events, complications, and intravenous PCA errors, ranged from $647 to $694.Conclusion: Although there is variation between different types of surgery, the hospital cost of intravenous PCA after major surgery is substantial. Novel technology should demonstrate cost-effectiveness in addition to clinical superiority.Keywords: patient-controlled analgesia, intravenous, total knee arthroplasty, total hip arthroplasty, abdominal surgery, cost
Published: 2014

50. Search for new physics in high-mass diphoton events from proton-proton collisions at s $$ \sqrt{\textrm{s}} $$ = 13 TeV

Author: The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, A. 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Wulansatiti, R. Yohay, B. Alsufyani, M. M. Baarmand, S. Butalla, S. Das, T. Elkafrawy, M. Hohlmann, M. Rahmani, E. Yanes, M. R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C. E. Gerber, M. Hawksworth, A. Hingrajiya, D. J. Hofman, J. h. Lee, D. S. Lemos, A. H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, E. Prifti, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, M. A. Wadud, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, S. Arteaga Escatel, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. 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Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, S. Malik, A. S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A. W. Jung, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, J. Lin, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, B. Chiarito, J. P. Chou, S. V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A. G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A. R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, G. Vorotnikov, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: Beyond Standard Model, Hadron-Hadron Scattering, Photon Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Results are presented from a search for new physics in high-mass diphoton events from proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV. The data set was collected in 2016–2018 with the CMS detector at the LHC and corresponds to an integrated luminosity of 138 fb −1. Events with a diphoton invariant mass greater than 500 GeV are considered. Two different techniques are used to predict the standard model backgrounds: parametric fits to the smoothly-falling background and a first-principles calculation of the standard model diphoton spectrum at next-to-next-to-leading order in perturbative quantum chromodynamics calculations. The first technique is sensitive to resonant excesses while the second technique can identify broad differences in the invariant mass shape. The data are used to constrain the production of heavy Higgs bosons, Randall-Sundrum gravitons, the large extra dimensions model of Arkani-Hamed, Dimopoulos, and Dvali (ADD), and the continuum clockwork mechanism. No statistically significant excess is observed. The present results are the strongest limits to date on ADD extra dimensions and RS gravitons with a coupling parameter greater than 0.1.
Published: 2024
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