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The scientists tend to assume that climatic factors are the only drivers in the development of drought. However, this classical assumption is no longer valid in the Anthropocene, as most catchments have been significantly modified by human factors. Recent theoretical developments have shown that there are mutual interactions and feedback mechanisms – drought shapes humans and vice versa. Therefore, this study aims to assess the role of human impacts on hydrological drought (HD) characteristics by considering runoff and baseflow separately. For this purpose, the two rainfall-runoff models: SWAT (Soil and Water Assessment Tool) and HBV (Hydrologiska Byrans Vattenbalansavdelning) models are compared. The results show significant differences in the magnitude of change between the two models, suggesting that the ensemble method of multiple models need to be considered for modelling human impact. However, the results confirm that despite significant differences in the magnitude of change, both hydrological models indicate similar impacts, i.e. positive and negative.

Hundreds of variants of Swarm Intelligence or Evolutionary Algorithms are proposed each year and numerous competitions and comparisons between algorithms may suggest rapid improvement in the field. However, such comparisons are often done between a limited number of methods and are based on averaged ranks of algorithms. This way they measure whether one method is on average ranked better than the others, without giving any information on how much improvement is in fact obtained. In this study we show a general comparison between 69 algorithms, starting from methods proposed in the 1960’s up to variants developed in the early 2020’s, on single-objective static numerical problems. Algorithms are compared on searching for a minimum of 30 different 50-dimensional mathematical functions, and on 22 real-world problems. We focus on the relative improvement achieved by various algorithms over a single-solution based method proposed in 1960 by Howard Rosenbrock. We find that the general improvement of Evolutionary Algorithms over Rosenbrock’s algorithm is relatively limited. It is high for the artificial benchmarks, for which many Evolutionary Algorithms find solutions 10 times closer to the global optimum in terms of fitness than Rosenbrock’s algorithm, but much lower for real-world problems. Improvement is also higher when performance averaged over many runs is compared, but lower when the best results from multiple runs are analyzed. In the last case, only the best Evolutionary Algorithms are able to find solutions of a “typical” real-world problem that are 2–3 times better in terms of fitness than those found by Rosenbrock’s algorithm. The relative improvement of recently proposed algorithms is not much better than the improvement achieved by algorithms proposed over a decade ago.

The air2water model is a simple and efficient tool for modeling surface water temperature in lakes based solely on the air temperature. In this article, we propose to modify the air2water model in such a way that different parameters would be associated with lake stratification of cold waters than with lake stratification of warm waters. The situation of a mix of both cold water and warm water is also considered. The model is tested on 22 lowland Polish lakes against two classical air2water variants. As the new air2water model variant is slightly more complicated than the basic versions, we focus on the importance of the choice of the calibration method. Each variant of the air2water model is calibrated with eight different optimization methods, which are also compared on various benchmark problems. We show that the proposed variant is superior to the classical air2water models on about 90% of tested lakes, but only if the calibration approach is properly selected, which confirms the importance of the links between the model and appropriate optimization procedures. The proposed air2water variant performs well on various lowland lakes, with exception of large but shallow ones, probably due to the weak stratification of the shallow lakes.

Background: Women are less likely to receive oral anticoagulation or ablation for treatment of atrial fibrillation (AF). Identification of sex differences in arrhythmia characteristics and symptoms may lead to a better understanding of potential reasons for these differences. Objectives: To determine sex differences in AF with respect to heart rate, duration, burden, and symptoms in patients undergoing mobile cardiac telemetry (MCT) monitoring. Methods: All patients who registered for ≤30-day MCT using PocketECG (MediLynx) in the USA in 2017 were included (n = 27,512, 58 % women). PocketECG records and transmits a three-lead ambulatory electrocardiogram (ECG) with real-time beat-to-beat analysis. Sex-related differences were analyzed with Chi2 and Spearmans rho. Results: Fewer women than men were diagnosed with AF lasting ≥30s (13.7 % versus [vs] 19.0 %, p

We report a detailed study of vector modulation instability (VMI) in highly birefringent fibers with circularly polarized modes in the normal dispersion regime. We show that because of suppression of coherent terms, the VMI in circularly birefringent fibers is governed by one set of coupled-mode nonlinear Schrödinger equations regardless of the fiber birefringence. In consequence, the VMI sidebands are polarized linearly and orthogonally to the pump up to the birefringence level of 10-5, similarly like in isotropic fibers. For greater birefringence the polarization states of the sidebands become elliptical with opposite handedness while the azimuth angle deviates from orthogonality to the pump. We also point on the dependence of the critical power beyond which the VMI cannot exist upon ellipticity angle θ of the eigenmodes. We show that the critical power gradually increases with the ellipticity angle and for θ > 17.6° the VMI gain is not limited, in contrast to linearly birefringent fibers. Our findings were confirmed experimentally by observation of the isotropic-like VMI in the spun side-hole fiber with nearly circularly polarized eigenmodes, in spite of relatively high birefringence of the order of 2 × 10-6.

Aging impacts both visual short-term memory (vSTM) capacity and thalamo-cortical connectivity. According to the Neural Theory of Visual Attention, vSTM depends on the structural connectivity between posterior thalamus and visual occipital cortices (PT-OC). We tested whether aging modifies the association between vSTM capacity and PT-OC structural connectivity. To do so, 66 individuals aged 20–77 years were assessed by diffusion-weighted imaging used for probabilistic tractography and performed a psychophysical whole-report task of briefly presented letter arrays, from which vSTM capacity estimates were derived. We found reduced vSTM capacity, and aberrant PT-OC connection probability in aging. Critically, age modified the relationship between vSTM capacity and PT-OC connection probability: in younger adults, vSTM capacity was negatively correlated with PT-OC connection probability while in older adults, this association was positive. Furthermore, age modified the microstructure of PT-OC tracts suggesting that the inversion of the association between PT-OC connection probability and vSTM capacity with aging might reflect age-related changes in white-matter properties. Accordingly, our results demonstrate that age-related differences in vSTM capacity links with the microstructure and connectivity of PT-OC tracts.

Vitamins K exert a range of activities that extend far beyond coagulation and include anti-inflammatory effects, but the mechanisms involved in anti-inflammatory action remain unclear. In the present study, we showed that various forms of exogenous vitamins—K1, K3, K2 (MK-4, MK-5, MK-6 and MK-7)—regulated a wide scope of inflammatory pathways in murine macrophages in vitro, including NOS-2, COX-2, cytokines and MMPs. Moreover, we demonstrated for the first time that macrophages are able to synthesise endogenous MK-4 on their own. Vitamins with shorter isoprenoid chains—K1, K3 and MK-5—exhibited stronger anti-inflammatory potential than vitamins with longer isoprenoid chains (MK-6 and MK-7) and simultaneously were preferably used as a substrate for MK-4 endogenous production. Most interesting, atorvastatin pretreatment inhibited endogenous MK-4 production but had no impact on the anti-inflammatory activity of vitamins K. In summary, our results demonstrate that macrophages are able to synthesise endogenous MK-4 using exogenous vitamins K, and statin inhibits this process. However, the anti-inflammatory effect of exogenous vitamins K was independent of endogenous MK-4 synthesis.

The goal of this study is to test applicability of the conceptual catchment run-off HBV model to simulate discharge in small non-glaciated Arctic catchment. Within two ablation seasons, 2014 and 2015, in the Fuglebekken catchment (Spitsbergen, Svalbard), selected hydro-meteorological measurements were conducted, including discharge measurements in 10 min interval by Nivus PCM-F device with active Doppler sensor. The model parameters were calibrated on discharge measurements from both years separately and verified independently. As the transformation from rainfall to runoff includes a number of processes with different dynamics and timescales, the proper description of the processes and their simulation of discharge depend on the temporal resolution of the data. For that purpose, the relationships between the calibration and validation results, and optimal model parameters with different time steps were analyzed. It was found that calculated fit of simulated to observed discharge, depends on the year, time step and data averaging. The best results were obtained for the model from year 2015 for 3 and 6 h using averaged input data.

A multi-step Coulomb excitation measurement with the GRETINA and CHICO2 detector arrays was carried out with a 430-MeV beam of the neutron-rich 110Ru (t1/2=12 s) isotope produced at the CARIBU facility. This represents the first successful measurement following the post-acceleration of an unstable isotope of a refractory element. The reduced transition probabilities obtained for levels near the ground state provide strong evidence for a triaxial shape; a conclusion confirmed by comparisons with the results of beyond-mean-field and triaxial rotor model calculations.

This paper presents a method of selecting the chemical composition and structure of the surface layer of construction materials to suit the property of the abrasive soil pulp being processed. The experiment was conducted in a laboratory, by the "rotating mass" method. The mathematical model developed for the experiment enables simulation of the wear changes of the construction materials used in soil, depending on changing of chemical composition and structure of the construction material and soil humidity. The results produced in the experiment have shown that the wear intensity in gravel soil may be acceptable for both materials containing less than 20 % C+Cr (used in soil with humidity of more than 12 %) and in tribological unfavourable conditions (soil humidity below 6 %), if the C+Cr content in the construction material exceeds 25 %.

We report on experimental studies of polarimetric sensitivity to torsion in spun highly birefringent fibers. Two classes of spun fibers were examined, namely spun side-hole fibers and birefringent microstructured fibers with different birefringence dispersion, spin pitches, and spin directions. The polarimetric sensitivity to torsion was determined by monitoring a displacement of the spectral interference fringes arising in the output signal because of interference of polarization modes and induced by an additional fiber twist. Both the experimental results and the analytical predictions showed that the sensitivity to torsion normalized to the fringe width in the spun highly birefringent fibers increased asymptotically with the twist rate to the value of 1/ π rad−1. We have also studied the polarimetric response to temperature in the spun side-hole fibers. We have found that, in contrast to the torsional sensitivity, the temperature sensitivity decays asymptotically to zero with increasing fiber twist rate. Therefore, the spun fibers with short spin pitches are especially well suited for torsion measurements because the torsional sensitivity and the range of linear response are both enhanced in such fibers, while at the same time, the cross-sensitivity to temperature is reduced.

The IS475 collaboration conducted Coulomb-excitation experiments with post-accelerated radioactive 220Rn and 224Ra beams at the REX-ISOLDE facility. The beam particles (Ebeam: 2.83 MeV/u) were Coulomb excited using 60Ni, 114Cd, and 120Sn scattering targets. De-excitation γ-rays were detected employing the Miniball array and scattered particles were detected in a silicon detector. Exploiting the Coulomb-excitation code GOSIA for each nucleus several matrix elements could be obtained from the measured γ-ray yields. The extracted ‹3−||E3||0+› matrix element allows for the conclusion that, while 220Rn represents an octupole vibrational system, 224Ra has already substantial octupole correlations in its ground state. This finding has implications for the search of CP-violating Schiff moments in the atomic systems of the adjacent odd-mass nuclei.

A rapid onset of quadrupole deformation is known to occur around the neutron number 60 in the neutron-rich Zr and Sr isotopes. This shape change has made the neutron-rich A = 100 region an active area of experimental and theoretical studies for many decades now. We report in this contribution new experimental results in the neutron rich 96,98Sr investigated by safe Coulomb excitation of radioactive beams at the REX-ISOLDE facility, CERN. Reduced transition probabilities and spectroscopic quadrupole moments have been extracted from the differential Coulomb excitation cross section supporting the scenario of shape coexistence/change at N=60. Future perspectives are presented including the recent experimental campaign performed at ILL-Grenoble.

The Radiopharmaceuticals Production and Research Centre was recently installed on the premises of the Heavy Ion Laboratory, University of Warsaw. Equipped with a medical PETtrace p/d cyclotron , radiochemistry synthesis and dispensing units and a modern quality control laboratory the Centre is intended to produce regularly for commercial purposes the classic PET radiopharmaceuticals ( such -as e.g. FDG- ). Situated on the largest Warsaw scientific campus OCHOTA, an important part of the Centre’s activities will also be devoted to the production of known species for preclinical studies and research into innovative radiopharmaceuticals in collaboration with other scientific units of this Campus as well as with members of the Warsaw Consortium for PET Collaboration. Research into the accelerator production route of 99mTc will also begin shortly.

A rapid onset of quadrupole deformation is known to occur around the neutron number 60 in the neutron-rich Zr and Sr isotopes. This shape change has made the neutron-rich A = 100 region an active area of experimental and theoretical studies for many decades now. We report in this contribution new experimental results in the neutron rich 96,98Sr investigated by safe Coulomb excitation of radioactive beams at the REX-ISOLDE facility, CERN. Reduced transition probabilities and spectroscopic quadrupole moments have been extracted from the differential Coulomb excitation cross section supporting the scenario of shape coexistence/change at N = 60. Future perspectives are presented including the recent experimental campaign performed at ILL-Grenoble.

Abstract Background Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. Methods Survivin and TP53 expression was evaluated immunohistochemically in 435 archival samples of ovarian carcinomas (244 patients were treated with platinum/cyclophosphamide-PC/PAC; 191-with taxane-platinum (TP) agents). Univariate and multivariate statistical analyses were performed in patients groups divided according to the administered chemotherapeutic regimen, and in subgroups with and without TP53 accumulation (TP53+ and TP53-, respectively). Results Nuclear and cytoplasmic survivin expression was observed in 92% and 74% of the carcinomas, respectively. In patients treated with TP, high nuclear survivin expression decreased the risk of disease recurrence and death, and increased the probability of high platinum sensitivity (p < 0.01), but only in the TP53(+) group, and not in the TP53(-) group. Conclusions It appears that TP53 status determines the clinical importance of nuclear survivin expression in taxane-platinum treated ovarian cancer patients.