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1. Diophantine approximations and almost periodic functions

Author: Nawrocki Adam
Subjects: Almost periodic function in the Lebesgue measure, continued fraction, Stepanov almost periodic function, 42A75, 11A55, 41A10, Mathematics, QA1-939
Abstract: In this paper we investigate the asymptotic behaviour of the classical continuous and unbounded almost periodic function in the Lebesgue measure.Using diophantine approximations we show that this function can be estimated by functions of polynomial type and we give the best polynomial estimation.
Published: 2017
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2. MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP

Author: Sarah Krukenberg, Franziska Möckl, Mariella Weiß, Patrick Dekiert, Melanie Hofmann, Fynn Gerlach, Kai J. Winterberg, Dejan Kovacevic, Imrankhan Khansahib, Berit Troost, Macarena Hinrichs, Viviana Granato, Mikolaj Nawrocki, Tobis Hub, Volodymyr Tsvilovskyy, Rebekka Medert, Lena-Marie Woelk, Fritz Förster, Huan Li, René Werner, Marcus Altfeld, Samuel Huber, Oliver Biggs Clarke, Marc Freichel, Björn-Philipp Diercks, Chris Meier, and Andreas H. Guse
Subjects: Science
Abstract: Abstract Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in many different cell types. Here, to directly stimulate NAADP signaling, MASTER-NAADP, a Membrane permeAble, STabilized, bio-rEversibly pRotected precursor of NAADP is synthesized and release of its active NAADP mimetic, benzoic acid C-nucleoside, 2’-phospho-3’F-adenosine-diphosphate, by esterase digestion is confirmed. In the presence of NAADP receptor HN1L/JPT2 (hematological and neurological expressed 1-like protein, HN1L, also known as Jupiter microtubule-associated homolog 2, JPT2), this active NAADP mimetic releases Ca2+ and increases the open probability of type 1 ryanodine receptor. When added to intact cells, MASTER-NAADP initially evokes single local Ca2+ signals of low amplitude. Subsequently, also global Ca2+ signaling is observed in T cells, natural killer cells, and Neuro2A cells. In contrast, control compound MASTER-NADP does not stimulate Ca2+ signaling. Likewise, in cells devoid of HN1L/JPT2, MASTER-NAADP does not affect Ca2+ signaling, confirming that the product released from MASTER-NAADP is a bona fide NAADP mimetic.
Published: 2024
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3. Bankart knee. Operative treatment of posterior part of lateral tibial condyle fracture with concomitant avulsion injury of anterior cruciate ligament (ACL). Technique and case report

Author: Wojciech Bocheński, Mateusz Nawrocki, Mikołaj Wróbel, Juliusz Sroczyński, Grzegorz Kłos, and Andrzej Mioduszewski
Subjects: Bankart knee, Bankart lesions, arthroscopic bony Bankart repair, tibial plateau fracture, impaction tibial plateau fracture, ACL avulsion injury, Orthopedic surgery, RD701-811
Abstract: Fractures of the posterolateral part of the tibial plateau (PLTP) are rare and complex fractures among other orthopedic entities. This case report describes a 54-year-old male who suffered a twisting injury of the left knee in a scooter crash. As a result, impaction fracture and displacement of the posterolateral margin of the tibial plateau were diagnosed with concomitant avulsion of the intercondylar eminence of the tibia and medial tibial condyle cleft fracture. The treatment comprised reduction of the medial tibial condyle (MTC) cleft fracture with one cancellous screw, arthroscopic bone-suture of the intercondylar eminence, and reduction of compressed PLTP with fixation of the displaced fragment on a distal radius T-plate working as a “buttress” rather than firm stabilizer. The operative technique of PLTP impaction fracture reduction is described in an instructional manner.
Published: 2024
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4. Stabilization of Anterior Aspect of Distal Tibiofibular Syndesmosis: A Fully Arthroscopic Technique

Author: Andrzej Mioduszewski, M.D., Ph.D., Mikołaj Wróbel, M.D., Juliusz Sroczyński, M.D., Grzegorz Kłos, M.D., Wojciech Bocheński, M.S., and Mateusz Nawrocki, M.S.
Subjects: Orthopedic surgery, RD701-811
Abstract: The anteroinferior tibiofibular ligament (AITFL) is 1 of the 4 ligaments forming the distal tibiofibular syndesmosis. When damaged, it is crucial to assess and address the lesion properly because a neglected or underdiagnosed lesion may invoke ankle osteoarthritis with underlying tibiofibular joint instability. In this technical note, we present a fully arthroscopic stabilization of the AITFL without the need for soft-tissue grafting. Our technique aims to create horizontal suture fixation over the damaged AITFL that serves as a mechanically efficient stabilization for the anterior aspect of the distal tibiofibular syndesmosis.
Published: 2024
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5. Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases

Author: Steffan T. Nawrocki, Claudia M. Espitia, Maria Janina Carrera Espinoza, Madison E. Gamble, Sruthi Sureshkumar, Mengyang Chang, Wei Wang, and Jennifer S. Carew
Subjects: autophagy, brain metastasis, breast cancer, hydroxychloroquine, lapatinib, Therapeutics. Pharmacology, RM1-950
Abstract: Abstract Patients with breast tumours that metastasise to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumours display altered energy production that results in enhanced autophagy. Preclinical studies have shown that genetically or pharmacologically disrupting the autophagy pathway significantly decreases the brain metastatic burden, resulting in improved animal survival and increased sensitivity to lapatinib. These findings pave the way for the development of novel strategies targeting autophagy for breast cancer patients with brain metastatic disease.
Published: 2024
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6. Combination of modified FOLFIRINOX with stereotactic body radiotherapy as an induction therapy for locally advanced pancreatic adenocarcinoma – a prospective single-arm study

Author: Michał Piątek, Michał Bieńkowski, Katarzyna Kuśnierz, Joanna Pilch-Kowalczyk, Dorota Imielska-Zdunek, Sławomir Mrowiec, Paweł Lampe, Barbara Radecka, and Sergiusz Nawrocki
Subjects: chemotherapy, health- related quality of life, neoadjuvant therapy, pancreatic ductal carcinoma, stereotactic body radiation therapy, Medicine
Published: 2024
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7. Estimation of the resonance frequency of rotational and translational signals evoked by mining-induced seismicity

Author: Dariusz Nawrocki, Maciej J. Mendecki, and Leslaw Teper
Subjects: horizontal-to-vertical spectral ratios, Fourier spectrum, response spectrum, rotational motion, mining seismicity, Science
Abstract: The horizontal-to-vertical (H/V) method is a fundamental fast tool to estimate local site effect parameters by using the registered signals of the translational motion. The spectral ratio is mostly calculated using the Fourier Spectrum Analysis (FSA), which may lead to problems with accurate resonant frequency determination due to evident multi-amplification peaks occurrence on the spectrum. Alternatively the H/V ratio may be estimated by use Response Spectrum Analysis (RSA), where only a general amplification peak is expected. However, the fundamental limitations of the RSA assumption are related to the real impact of the events’ scenario dependence (i.e., magnitude, distance, focal mechanism, etc.). The limitations and advantages of the RSA and FSA are commonly known in the case of the analysis performed for the translational signals. Therefore, the critical question is: should the RSA and FSA methods be used to estimate the H/V ratio of the recorded rotational signals of the events? The article presents horizontal-to-vertical (H/V) spectral ratios calculated for rotational and translational signals registered as an effect of mining-induced seismicity by four independent seismic stations located in Poland's Upper Silesian Coal basin. The spectral ratios of the signals were estimated using the RSA and the FSA method. The studies show that in the case of translational motion, the H/V estimations using the RSA derived clear information of the resonant frequency peak, confirming the method’s usefulness in the case of multi-amplification peaks. The opposite situation was noticed in the case of the rotational motion. The derived H/V spectrum, using the RSA, produced single amplification peaks for the seismic stations, where the sensors were mounted on a small floor at a significant distance from the walls. In cases where the sensors were deployed on the building floor, a decrease in the reliability of the RSA and the FSA method was noticed. The results of the studies suggested that the possibility of the estimations of the H/V spectrum using the RSA and FSA algorithm is strongly limited for rotational motions due to the size of the floor and distance to the building walls where the sensors were mounted. The explanation of that fact is related to the effects of kinematic soil-structure interaction, which may significantly affect rotational measurements due to the tendency to obtain higher frequency content than in the case of the translations. Consequently, the values of the Z- component of the rotational motion may be lovered than in the free-field measurements, decreasing the reliability of the H/V estimations for rotational motion.
Published: 2024
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8. Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib

Author: Steffan T. Nawrocki, Claudia M. Espitia, Maria Janina Carrera Espinoza, Trace M. Jones, Madison E. Gamble, Sruthi Sureshkumar, Mengyang Chang, Wei Wang, and Jennifer S. Carew
Subjects: Medicine (General), R5-920
Published: 2024
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9. SP05. Development And Evaluation Of A Rat Exoskeleton Controlled By Muscle Cuff Regenerative Peripheral Nerve Interface (MC-RPNI) Signals For Optimal Motor Control

Author: Katherine L. Burke, MD, Yucheng Tian, MSE, Hannah R. Kuperus, BS, Devon P. Kelly, PhD, Elise R. Nawrocki, BS, Richard B. Gillespie, PhD, Paul S. Cederna, MD, and Stephen W.P. Kemp, PhD
Subjects: Surgery, RD1-811
Published: 2024
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10. A protective effect of inflammatory bowel disease on the severity of sclerosing cholangitis

Author: Friederike Stumme, Niklas Steffens, Babett Steglich, Franziska Mathies, Mikolaj Nawrocki, Morsal Sabihi, Shiwa Soukou-Wargalla, Emilia Göke, Jan Kempski, Thorben Fründt, Sören Weidemann, Christoph Schramm, Nicola Gagliani, Samuel Huber, and Tanja Bedke
Subjects: primary sclerosing cholangitis, inflammatory bowel disease, Mdr2 knock out, microbiota, colitis, Immunologic diseases. Allergy, RC581-607
Abstract: BackgroundPrimary sclerosing cholangitis (PSC) is a chronic liver disease marked by inflammation of the bile ducts and results in the development of strictures and fibrosis. A robust clinical correlation exists between PSC and inflammatory bowel disease (IBD). At present, published data are controversial, and it is yet unclear whether IBD drives or attenuates PSC.MethodsMdr2-deficient mice or DDC-fed mice were used as experimental models for sclerosing cholangitis. Additionally, colitis was induced in mice with experimental sclerosing cholangitis, either through infection with Citrobacter rodentium or by feeding with DSS. Lastly, fibrosis levels were determined through FibroScan analysis in people with PSC and PSC-IBD.ResultsUsing two distinct experimental models of colitis and two models of sclerosing cholangitis, we found that colitis does not aggravate liver pathology, but rather reduces liver inflammation and liver fibrosis. Likewise, people with PSC-IBD have decreased liver fibrosis compared to those with PSC alone.ConclusionsWe found evidence that intestinal inflammation attenuates liver pathology. This study serves as a basis for further research on the pathogenesis of PSC and PSC-IBD, as well as the molecular mechanism responsible for the protective effect of IBD on PSC development. This study could lead to the discovery of novel therapeutic targets for PSC.
Published: 2024
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11. Corrigendum to 'A Comparative Study on Antimicrobial Resistance in Escherichia coli Isolated from Channel Catfish and Related Freshwater Fish Species' [J. Food Protect. 87(1) (2023) 100192]

Author: Yesutor K. Soku, Abdelrahman Mohamed, Temesgen Samuel, Uday Dessai, Isabel Walls, Catherine Rockwell, Gamola Fortenberry, Tracy Berutti, Sharon Nieves-Miranda, Erin M. Nawrocki, Yezhi Fu, Edward Dudley, Stephen W. Mamber, and John Hicks
Subjects: Food processing and manufacture, TP368-456, Nutrition. Foods and food supply, TX341-641
Published: 2024
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12. Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level

Author: Jöran Lücke, Marius Böttcher, Mikolaj Nawrocki, Nicholas Meins, Josa Schnell, Fabian Heinrich, Franziska Bertram, Morsal Sabihi, Philipp Seeger, Marie Pfaff, Sara Notz, Tom Blankenburg, Tao Zhang, Jan Kempski, Matthias Reeh, Stefan Wolter, Oliver Mann, Marc Lütgehetmann, Thilo Hackert, Jakob R. Izbicki, Anna Duprée, Samuel Huber, Benjamin Ondruschka, and Anastasios D. Giannou
Subjects: Science (General), Q1-390, Social sciences (General), H1-99
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.
Published: 2024
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13. A Comparative Study on Antimicrobial Resistance in Escherichia coli Isolated from Channel Catfish and Related Freshwater Fish Species

Author: Yesutor K. Soku, Abdelrahman Mohamed, Temesgen Samuel, Uday Dessai, Isabel Walls, Catherine Rockwell, Gamola Fortenberry, Tracy Berutti, Sharon Nieves-Miranda, Erin M. Nawrocki, Yezhi Fu, Edward Dudley, Stephen W. Mamber, and John Hicks
Subjects: Antibiotics, Antimicrobials, Bacteria, Fish, Resistant genes, Food processing and manufacture, TP368-456, Nutrition. Foods and food supply, TX341-641
Abstract: Antimicrobial resistance (AMR) trends in 114 generic Escherichia coli isolated from channel catfish and related fish species were investigated in this study. Of these, 45 isolates were from commercial-sized channel catfish harvested from fishponds in Alabama, while 69 isolates were from Siluriformes products, accessed from the U.S. Department of Agriculture Food Safety and Inspection Service’ (FSIS) National Antimicrobial Resistance Monitoring System (NARMS) program. Antibiotic susceptibility testing and whole genome sequencing were performed using the GenomeTrakr protocol. Upon analysis, the fishpond isolates showed resistance to ampicillin (44%), meropenem (7%) and azithromycin (4%). The FSIS NARMS isolates showed resistance to tetracycline (31.9%), chloramphenicol (20.3%), sulfisoxazole (17.4%), ampicillin (5.8%) and trimethoprim-sulfamethoxazole, nalidixic acid, amoxicillin-clavulanic acid, azithromycin and cefoxitin below 5% each. There was no correlation between genotypic and phenotypic resistance in the fishpond isolates, however, there was in NARMS isolates for folate pathway antagonists: Sulfisoxazole vs. sul1 and sul2 (p = 0.0042 and p < 0.0001, respectively) and trimethoprim-sulfamethoxazole vs. dfrA16 and sul1 (p = 0.0290 and p = 0.013, respectively). Furthermore, correlations were found for tetracyclines: Tetracycline vs. tet(A) and tet(B) (p < 0.0001 each), macrolides: Azithromycin vs. mph(E) and msr(E) (p = 0.0145 each), phenicols: Chloramphenicol vs. mdtM (p < 0.0001), quinolones: Nalidixic acid vs. gyrA_S83L=POINT (p = 0.0004), and β-lactams: Ampicillin vs. blaTEM-1 (p < 0.0001). Overall, we recorded differences in antimicrobial susceptibility testing profiles, phenotypic-genotypic concordance, and resistance to critically important antimicrobials, which may be a public health concern.
Published: 2024
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14. A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model

Author: Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, and Simon A. Hinke
Subjects: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270
Abstract: Abstract Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐like (GFRAL) receptor expressed in the area postrema. To characterize sustained GFRAL agonism on food intake (FI) and body weight (BW), we tested a half‐life extended analog of GDF15 (Compound H [CpdH]) suitable for reduced dosing frequency in obese cynomolgus monkeys. Animals were chronically treated once weekly (q.w.) with CpdH or long‐acting GLP‐1 analog dulaglutide. Mechanism‐based longitudinal exposure‐response modeling characterized effects of CpdH and dulaglutide on FI and BW. The novel model accounts for both acute, exposure‐dependent effects reducing FI and compensatory changes in energy expenditure (EE) and FI occurring over time with weight loss. CpdH had linear, dose‐proportional pharmacokinetics (terminal half‐life ~8 days) and treatment caused exposure‐dependent reductions in FI and BW. The 1.6 mg/kg CpdH reduced mean FI by 57.5% at 1 week and sustained FI reductions of 31.5% from weeks 9–12, resulting in peak reduction in BW of 16 ± 5%. Dulaglutide had more modest effects on FI and peak BW loss was 3.8 ± 4.0%. Longitudinal modeling of both the FI and BW profiles suggested reductions in BW observed with both CpdH and dulaglutide were fully explained by exposure‐dependent reductions in FI without increase in EE. Upon verification of the pharmacokinetic/pharmacodynamic relationship established in monkeys and humans for dulaglutide, we predicted that CpdH could reach double digit BW loss in humans. In summary, a long‐acting GDF15 analog led to sustained reductions in FI in overweight monkeys and holds potential for effective clinical obesity pharmacotherapy.
Published: 2023
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15. 270 n m ultra-thin self-adhesive conformable and long-term air-stable complimentary organic transistors and amplifiers

Author: Mohammad Javad Mirshojaeian Hosseini, Yi Yang, Walter Kruger, Tomoyuki Yokota, Sunghoon Lee, Takao Someya, and Robert A. Nawrocki
Subjects: Electronics, TK7800-8360, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: Abstract Lightweight, flexible, and conformal bioelectronics are essential for wearable technologies. This paper introduces 270 nm thin organic electronics amplifying circuits that are self-adhesive, skin conformal, and long-term air-stable. This report studies the effect of total device thickness, namely 3 μm and 270 nm devices, on the characterization of organic devices before and after buckling, the longevity of organic field-effect transistors (OFETs) over 5 years, and the lamination of OFETs on the human skin. A single-stage organic complementary inverter and a pseudo-complementary amplifier are fabricated to compare their electrical characteristics, with amplification gains of 10 and 64, respectively. Finally, the study demonstrates a five-stage organic complementary inverter can successfully amplify artificial electromyogram and electrocardiogram signals with gains of 1000 and 1088, respectively.
Published: 2023
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16. Weak acids produced during anaerobic respiration suppress both photosynthesis and aerobic respiration

Author: Xiaojie Pang, Wojciech J. Nawrocki, Pierre Cardol, Mengyuan Zheng, Jingjing Jiang, Yuan Fang, Wenqiang Yang, Roberta Croce, and Lijin Tian
Subjects: Science
Abstract: Abstract While photosynthesis transforms sunlight energy into sugar, aerobic and anaerobic respiration (fermentation) catabolizes sugars to fuel cellular activities. These processes take place within one cell across several compartments, however it remains largely unexplored how they interact with one another. Here we report that the weak acids produced during fermentation down-regulate both photosynthesis and aerobic respiration. This effect is mechanistically explained with an “ion trapping” model, in which the lipid bilayer selectively traps protons that effectively acidify subcellular compartments with smaller buffer capacities – such as the thylakoid lumen. Physiologically, we propose that under certain conditions, e.g., dim light at dawn, tuning down the photosynthetic light reaction could mitigate the pressure on its electron transport chains, while suppression of respiration could accelerate the net oxygen evolution, thus speeding up the recovery from hypoxia. Since we show that this effect is conserved across photosynthetic phyla, these results indicate that fermentation metabolites exert widespread feedback control over photosynthesis and aerobic respiration. This likely allows algae to better cope with changing environmental conditions.
Published: 2023
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17. Properties and Application of the Gummetal Wire for the Treatment of an Open Bite—Brief Narrative Review and Case Report

Author: Anna Ewa Kuc, Jacek Kotuła, Jakub Nawrocki, Maciej Dobrzyński, Rafał J. Wiglusz, Adam Watras, Michał Sarul, Joanna Lis, and Beata Kawala
Subjects: Gummetal, orthodontic wire, open bite treatment, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract: The swift integration of ‘Gummetal’ into the orthodontic armamentarium can be attributed to its distinct advantages as an entirely new Ti-Nb-based beta titanium alloy. Developed by Toyota Central R&D Labs and publicly revealed in April 2003, this innovative material is rapidly reshaping orthodontic practices. Its sui generis properties allow its use as a potential substitute for the Multi-Loop Edgewise Archwire (MEAW) method. Three-dimensional orthodontic movement using this new alloy could eliminate the disadvantages of the MEAW method, such as its technical complexity and patient discomfort. In our comprehensive review of the current literature, we examined relevant publications sourced from the PUBMED database and explored one seminal work on Gummetal from the journal literature. Characteristic properties of Gummetal, such as its exceptional flexibility, superelasticity, and malleability (approximately 10 times greater than conventional metals), enable seamless formation of bends without posing challenges, thereby allowing precise control over orthodontic force application. Also worthy of mention are Gummetal’s biocompatibility and non-toxic properties, along with its low coefficient of friction. The wire seems to be a relatively easy way to achieve good occlusion. Its usage does not require extensive experience in terms of manual skill, and it is not time consuming. Diligent usage of any prescribed plastics by the patient is crucial to prevent complications and ensure successful orthodontic outcomes.
Published: 2024
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18. The structural basis of tRNA recognition by arginyl-tRNA-protein transferase

Author: Thilini Abeywansha, Wei Huang, Xuan Ye, Allison Nawrocki, Xin Lan, Eckhard Jankowsky, Derek J. Taylor, and Yi Zhang
Subjects: Science
Abstract: Abstract Arginyl-tRNA-protein transferase 1 (ATE1) is a master regulator of protein homeostasis, stress response, cytoskeleton maintenance, and cell migration. The diverse functions of ATE1 arise from its unique enzymatic activity to covalently attach an arginine onto its protein substrates in a tRNA-dependent manner. However, how ATE1 (and other aminoacyl-tRNA transferases) hijacks tRNA from the highly efficient ribosomal protein synthesis pathways and catalyzes the arginylation reaction remains a mystery. Here, we describe the three-dimensional structures of Saccharomyces cerevisiae ATE1 with and without its tRNA cofactor. Importantly, the putative substrate binding domain of ATE1 adopts a previously uncharacterized fold that contains an atypical zinc-binding site critical for ATE1 stability and function. The unique recognition of tRNAArg by ATE1 is coordinated through interactions with the major groove of the acceptor arm of tRNA. Binding of tRNA induces conformational changes in ATE1 that helps explain the mechanism of substrate arginylation.
Published: 2023
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19. An examination of scenarios to increase waterfowl hunting participation

Author: Matthew P. Hinrichs, Julia Nawrocki, Matthew P. Gruntorad, Mark P. Vrtiska, Mark A. Pegg, and Christopher J. Chizinski
Subjects: conservation, constraints, hunter participation, preference, social science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract: Abstract Since the 1970s, waterfowl hunting participation has declined in the United States, which has resulted in socioeconomic consequences for waterfowl conservation and management. Attempts to increase the waterfowl hunter population have been difficult, partly due to social factors (e.g., constraints, motivations, demographics) influencing who participates, frequency of participation, and diversity of desired outcomes from hunting experiences. We examined the preferences of 10 potential management options by hunters and anglers from several states in the central U.S. during 2018. Respondents were grouped into the following activity groups based on responses to survey questions: frequent waterfowl hunters, sporadic waterfowl hunters, previous waterfowl hunters, hunters (never hunted waterfowl), and nonhunters (anglers who have never hunted). All ordinal models indicated that the ability of the scenario to increase participation significantly (P 0.35 for all activity groups) and Special areas for new waterfowl hunters, had the greatest indication (probability > 0.40) of increased waterfowl hunting participation across activity groups. Frequent and sporadic waterfowl hunters ranked Special areas to allow for a quality hunt highest, while hunters and non‐hunters ranked Someone to take me hunting as the most preferred scenario. Information for what new/inexperienced hunters need, Classes or materials to teach waterfowl ID, and Ability to rent equipment were scenarios consistently ranked as the lowest for all activity groups. Our research underscores that only some of the scenarios had the same appeal to all activity groups, which implies a need for a greater diversity of experiences in the landscape of public waterfowl hunting access. Also, continued promotion of current waterfowl hunters taking new or inexperienced individuals may increase waterfowl hunting participation.
Published: 2023
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20. Acceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA

Author: Courtney C. Nawrocki, Nicholas Piedmonte, Sara A. Niesobecki, Adam Rowe, AmberJean P. Hansen, Alison Kaufman, Erik Foster, James I. Meek, Linda Niccolai, Jennifer White, Bryon Backenson, Lars Eisen, Sarah A. Hook, Neeta P. Connally, Victoria L. Hornbostel, and Alison F. Hinckley
Subjects: Lyme disease, Tick-borne disease, Prevention, Ticks, Humans, Infectious and parasitic diseases, RC109-216
Abstract: The 4-Poster Tick Control Deer Feeder (4-poster) device applies acaricide to white-tailed deer (Odocoileus virginianus) and can reduce populations of the blacklegged tick (Ixodes scapularis), which transmits the agents of Lyme disease, anaplasmosis, babesiosis, and Powassan virus disease in the Northeastern United States. While 4-poster devices have the potential to provide community-wide management of blacklegged ticks in Lyme disease endemic areas, no recent study has assessed their acceptability among residents. We conducted a survey of residents from 16 counties with high annual average Lyme disease incidence (≥ 10 cases per 100,000 persons between 2013 and 2017) in Connecticut and New York to understand perceptions and experiences related to tickborne diseases, support or concerns for placement of 4-poster devices in their community, and opinions on which entities should be responsible for tick control on private properties. Overall, 37% of 1652 respondents (5.5% response rate) would support placement of a 4-poster device on their own property, 71% would support placement on other private land in their community, and 90% would support placement on public land. Respondents who were male, rented their property, resided on larger properties, or were very or extremely concerned about encountering ticks on their property were each more likely to support placement of 4-poster devices on their own property. The primary reason for not supporting placement of a 4-poster device on one's own property was the need for weekly service visits from pest control professionals, whereas the top reason for not supporting placement on other land (private or public) was safety concerns. Most respondents (61%) felt property owners should be responsible for tick control on private properties. Communities considering 4-poster devices as part of a tick management strategy should consider targeting owners of larger properties and placing devices on public lands.
Published: 2023
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21. Konsekwencje stosowania nakładek na złączach spawanych

Author: Kwiryn Wojsyk and Jerzy Nawrocki
Subjects: welding rules, fracture mechanics, tiredness, Technology (General), T1-995
Abstract: W artykule odniesiono się do wcześniejszej publikacji dotyczącej nakładek wzmacniających na złączach spawanych. W tym kontekście przypominano główne zasady projektowania konstrukcji spawanych. W celu weryfikacji zasady o nie stosowaniu nakładek na spoinach wykonano symulację MES takiego modelu.
Published: 2023
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22. Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

Author: Skjøt-Arkil Helene, Clausen Rikke E, Nguyen Quoc Hai, Wang Yaguo, Zheng Qinlong, Martinez Fernando J, Hogaboam Cory M, Han Meilan, Klickstein Lloyd B, Larsen Martin R, Nawrocki Arkadiusz, Leeming Diana J, and Karsdal Morten A
Subjects: Elastin, Extracellular matrix remodeling, Biochemical marker, Neoepitope, COPD, IPF, MMP, Diseases of the respiratory system, RC705-779
Abstract: Abstract Background Elastin is an essential component of selected connective tissues that provides a unique physiological elasticity. Elastin may be considered a signature protein of lungs where matrix metalloprotease (MMP) -9-and -12, may be considered the signature proteases of the macrophages, which in part are responsible for tissue damage during disease progression. Thus, we hypothesized that a MMP-9/-12 generated fragment of elastin may be a relevant biochemical maker for lung diseases. Methods Elastin fragments were identified by mass-spectrometry and one sequence, generated by MMP-9 and -12 (ELN-441), was selected for monoclonal antibody generation and used in the development of an ELISA. Soluble and insoluble elastin from lung was cleaved in vitro and the time-dependent release of fragments was assessed in the ELN-441 assay. The release of ELN-441 in human serum from patients with chronic obstructive pulmonary disease (COPD) (n = 10) and idiopathic pulmonary fibrosis (IPF) (n = 29) were compared to healthy matched controls (n = 11). Results The sequence ELN-441 was exclusively generated by MMP-9 and -12 and was time-dependently released from soluble lung elastin. ELN-441 levels were 287% higher in patients diagnosed with COPD (p Conclusions MMP-9 and -12 time-dependently released the ELN-441 epitope from elastin. This fragment was elevated in serum from patients with the lung diseases IPF and COPD, however these data needs to be validated in larger clinical settings.
Published: 2012
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23. Is It Possible to Notice the Unmet Non-Medical Needs among Cancer Patients? Application of the Needs Evaluation Questionnaire in Men with Lung Cancer

Author: Karolina Osowiecka, Marcin Kurowicki, Jarosław Kołb-Sielecki, Anna Gwara, Marek Szwiec, Sergiusz Nawrocki, and Monika Rucińska
Subjects: men’s health, lung cancer, non-medical needs, NEQ, quality of life, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Lung cancer is the most common cause of cancer death worldwide. It is the most frequently diagnosed cancer in men. Lung cancer causes not only physical symptoms related to the disease itself and its treatment but also numerous mental, social and spiritual problems. The aim of the study was to assess non-medical needs among male lung cancer patients during oncological treatment. Materials and Methods: The study was conducted on a group of 160 men (mean age 67 years) treated for lung cancer from June 2022 until November 2022 in 5 oncological centers in Poland. The Needs Evaluation Questionnaire (NEQ) was used. The NEQ explores five areas of patients’ needs: informative, connected with assistance/care, relational, material and psycho-emotional support. Results: All participants (except one) expressed some unmet non-medical needs (mean and median 11). Male lung cancer patients indicated informative needs most frequently. There were no significant differences between expressed unmet needs based on age, place of residence, professional activity or marital status. Conclusions: The NEQ seems to be a proper instrument to explore the non-medical needs of cancer patients. Adequate measures to address the unmet needs of lung cancer patients could contribute to an improved quality of life.
Published: 2023
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24. Erratum: Measurement of prompt and nonprompt charmonium suppression in PbPb collisions at 5.02 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Maerschalk, A. Marinov, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, F. Zenoni, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, S. Salva, M. Tytgat, W. Verbeke, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, M. Komm, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, M. Correa Martins Junior, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, L. M. Huertas Guativa, H. Malbouisson, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, S. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, F. Zhang, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, J. D. Ruiz Alvarez, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, M. A. Mahmoud, Y. Mohammed, E. Salama, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, A. Tiko, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, P. Gras, G. Hamel de Monchenault, P. Jarry, I. Kucher, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. 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Josa, D. Moran, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, A. Quintario Olmeda, I. Redondo, L. Romero, M. S. Soares, C. Albajar, J. F. de Trocóniz, M. Missiroli, J. Cuevas, C. Erice, J. Fernandez Menendez, I. Gonzalez Caballero, J. R. González Fernández, E. Palencia Cortezon, S. Sanchez Cruz, P. Vischia, J. M. Vizan Garcia, I. J. Cabrillo, A. Calderon, B. Chazin Quero, E. Curras, J. Duarte Campderros, M. Fernandez, J. Garcia-Ferrero, G. Gomez, A. Lopez Virto, J. Marco, C. Martinez Rivero, P. Martinez Ruiz del Arbol, F. Matorras, J. Piedra Gomez, T. Rodrigo, A. Ruiz-Jimeno, L. Scodellaro, N. Trevisani, I. Vila, R. Vilar Cortabitarte, D. Abbaneo, B. Akgun, E. Auffray, P. Baillon, A. H. Ball, D. Barney, J. Bendavid, M. Bianco, P. Bloch, A. Bocci, C. Botta, T. Camporesi, R. Castello, M. Cepeda, G. Cerminara, E. Chapon, D. d’Enterria, A. Dabrowski, V. Daponte, A. David, M. De Gruttola, A. De Roeck, N. Deelen, M. Dobson, T. du Pree, M. Dünser, N. Dupont, A. Elliott-Peisert, P. Everaerts, F. Fallavollita, G. Franzoni, J. Fulcher, W. Funk, D. Gigi, A. Gilbert, K. Gill, F. Glege, D. Gulhan, P. Harris, J. Hegeman, V. Innocente, A. Jafari, P. Janot, O. Karacheban, J. Kieseler, V. Knünz, A. Kornmayer, M. J. Kortelainen, M. Krammer, C. Lange, P. Lecoq, C. Lourenço, M. T. Lucchini, L. Malgeri, M. Mannelli, A. Martelli, F. Meijers, J. A. Merlin, S. Mersi, E. Meschi, P. Milenovic, F. Moortgat, M. Mulders, H. Neugebauer, J. Ngadiuba, S. Orfanelli, L. Orsini, L. Pape, E. Perez, M. Peruzzi, A. Petrilli, G. Petrucciani, A. Pfeiffer, M. Pierini, D. Rabady, A. Racz, T. Reis, G. Rolandi, M. Rovere, H. Sakulin, C. Schäfer, C. Schwick, M. Seidel, M. Selvaggi, P. Silva, P. Sphicas, A. Stakia, J. Steggemann, M. Stoye, M. Tosi, D. Treille, A. Triossi, A. Tsirou, V. Veckalns, M. Verweij, W. D. Zeuner, W. Bertl, L. Caminada, K. Deiters, W. Erdmann, R. Horisberger, Q. Ingram, H. C. Kaestli, D. Kotlinski, U. Langenegger, T. Rohe, S. A. Wiederkehr, M. Backhaus, L. Bäni, P. Berger, L. Bianchini, B. Casal, G. Dissertori, M. Dittmar, M. Donegà, C. Dorfer, C. Grab, C. Heidegger, D. Hits, J. Hoss, G. Kasieczka, T. Klijnsma, W. Lustermann, B. Mangano, M. Marionneau, M. T. Meinhard, D. Meister, F. Micheli, P. Musella, F. Nessi-Tedaldi, F. Pandolfi, J. Pata, F. Pauss, G. Perrin, L. Perrozzi, M. Quittnat, M. Reichmann, D. A. Sanz Becerra, M. Schönenberger, L. Shchutska, V. R. Tavolaro, K. Theofilatos, M. L. Vesterbacka Olsson, R. Wallny, D. H. Zhu, T. K. Aarrestad, C. Amsler, M. F. Canelli, A. De Cosa, R. Del Burgo, S. Donato, C. Galloni, T. Hreus, B. Kilminster, D. Pinna, G. Rauco, P. Robmann, D. Salerno, K. Schweiger, C. Seitz, Y. Takahashi, A. Zucchetta, V. Candelise, Y. H. Chang, K. y. Cheng, T. H. Doan, Sh. Jain, R. Khurana, C. M. Kuo, W. Lin, A. Pozdnyakov, S. S. Yu, Arun Kumar, P. Chang, Y. Chao, K. F. Chen, P. H. Chen, F. Fiori, W.-S. Hou, Y. Hsiung, Y. F. Liu, R.-S. Lu, E. Paganis, A. Psallidas, A. Steen, J. F. Tsai, B. Asavapibhop, K. Kovitanggoon, G. Singh, N. Srimanobhas, M. N. Bakirci, A. Bat, F. Boran, S. Damarseckin, Z. S. Demiroglu, C. Dozen, E. Eskut, S. Girgis, G. Gokbulut, Y. Guler, I. Hos, E. E. Kangal, O. Kara, U. Kiminsu, M. Oglakci, G. Onengut, K. Ozdemir, S. Ozturk, D. Sunar Cerci, U. G. Tok, H. Topakli, S. Turkcapar, I. S. Zorbakir, C. Zorbilmez, G. Karapinar, K. Ocalan, M. Yalvac, M. Zeyrek, E. Gülmez, M. Kaya, O. Kaya, S. Tekten, E. A. Yetkin, M. N. Agaras, S. Atay, A. Cakir, K. Cankocak, I. Köseoglu, B. Grynyov, L. Levchuk, F. Ball, L. Beck, J. J. Brooke, D. Burns, E. Clement, D. Cussans, O. Davignon, H. Flacher, J. Goldstein, G. P. Heath, H. F. Heath, L. Kreczko, D. M. Newbold, S. Paramesvaran, T. Sakuma, S. Seif El Nasr-storey, D. Smith, V. J. Smith, C. Brew, R. M. Brown, L. Calligaris, D. Cieri, D. J. A. Cockerill, J. A. Coughlan, K. Harder, S. Harper, J. Linacre, E. Olaiya, D. Petyt, C. H. Shepherd-Themistocleous, A. Thea, I. R. Tomalin, T. Williams, G. Auzinger, R. Bainbridge, J. Borg, S. Breeze, O. Buchmuller, A. Bundock, S. Casasso, M. Citron, D. Colling, L. Corpe, P. Dauncey, G. Davies, A. De Wit, M. Della Negra, R. Di Maria, A. Elwood, Y. Haddad, G. Hall, G. Iles, T. James, R. Lane, C. Laner, L. Lyons, A.-M. Magnan, S. Malik, L. Mastrolorenzo, T. Matsushita, J. Nash, A. Nikitenko, V. Palladino, M. Pesaresi, D. M. Raymond, A. Richards, A. Rose, E. Scott, C. Seez, A. Shtipliyski, S. Summers, A. Tapper, K. Uchida, M. Vazquez Acosta, T. Virdee, N. Wardle, D. Winterbottom, J. Wright, S. C. Zenz, J. E. Cole, P. R. Hobson, A. Khan, P. Kyberd, I. D. Reid, L. Teodorescu, S. Zahid, A. Borzou, K. Call, J. Dittmann, K. Hatakeyama, H. Liu, N. Pastika, C. Smith, R. Bartek, A. Dominguez, A. Buccilli, S. I. Cooper, C. Henderson, P. Rumerio, C. West, D. Arcaro, A. Avetisyan, T. Bose, D. Gastler, D. Rankin, C. Richardson, J. Rohlf, L. Sulak, D. Zou, G. Benelli, D. Cutts, A. Garabedian, M. Hadley, J. Hakala, U. Heintz, J. M. Hogan, K. H. M. Kwok, E. Laird, G. Landsberg, Z. Mao, M. Narain, J. Pazzini, S. Piperov, S. Sagir, R. Syarif, D. Yu, R. Band, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, J. Conway, R. Conway, P. T. Cox, R. Erbacher, C. Flores, G. Funk, W. Ko, R. Lander, C. Mclean, M. Mulhearn, D. Pellett, J. Pilot, S. Shalhout, M. Shi, J. Smith, D. Stolp, K. Tos, M. Tripathi, M. Bachtis, C. Bravo, R. Cousins, A. Dasgupta, A. Florent, J. Hauser, M. Ignatenko, N. Mccoll, S. Regnard, D. Saltzberg, C. Schnaible, V. Valuev, E. Bouvier, K. Burt, R. Clare, J. Ellison, J. W. Gary, S. M. A. Ghiasi Shirazi, G. Hanson, J. Heilman, G. Karapostoli, E. Kennedy, F. Lacroix, O. R. Long, M. Olmedo Negrete, M. I. Paneva, W. Si, L. Wang, H. Wei, S. Wimpenny, B. R. Yates, J. G. Branson, S. Cittolin, M. Derdzinski, R. Gerosa, D. Gilbert, B. Hashemi, A. Holzner, D. Klein, G. Kole, V. Krutelyov, J. Letts, M. Masciovecchio, D. Olivito, S. Padhi, M. Pieri, M. Sani, V. Sharma, M. Tadel, A. Vartak, S. Wasserbaech, J. Wood, F. Würthwein, A. Yagil, G. Zevi Della Porta, N. Amin, R. Bhandari, J. Bradmiller-Feld, C. Campagnari, A. Dishaw, V. Dutta, M. Franco Sevilla, L. Gouskos, R. Heller, J. Incandela, A. Ovcharova, H. Qu, J. Richman, D. Stuart, I. Suarez, J. Yoo, D. Anderson, A. Bornheim, J. M. Lawhorn, H. B. Newman, T. Nguyen, C. Pena, M. Spiropulu, J. R. Vlimant, S. Xie, Z. Zhang, R. Y. Zhu, M. B. Andrews, T. Ferguson, T. Mudholkar, M. Paulini, J. Russ, M. Sun, H. Vogel, I. Vorobiev, M. Weinberg, J. P. Cumalat, W. T. Ford, F. Jensen, A. Johnson, M. Krohn, S. Leontsinis, T. Mulholland, K. Stenson, S. R. Wagner, J. Alexander, J. Chaves, J. Chu, S. Dittmer, K. Mcdermott, N. Mirman, J. R. Patterson, D. Quach, A. Rinkevicius, A. Ryd, L. Skinnari, L. Soffi, S. M. Tan, Z. Tao, J. Thom, J. Tucker, P. Wittich, M. Zientek, S. Abdullin, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, A. Apyan, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, G. Bolla, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, M. Cremonesi, J. Duarte, V. D. Elvira, J. Freeman, Z. Gecse, E. Gottschalk, L. Gray, D. Green, S. Grünendahl, O. Gutsche, R. M. Harris, S. Hasegawa, J. Hirschauer, Z. Hu, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, B. Klima, B. Kreis, S. Lammel, D. Lincoln, R. Lipton, M. Liu, T. Liu, R. Lopes De Sá, J. Lykken, K. Maeshima, N. Magini, J. M. Marraffino, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, V. O’Dell, K. Pedro, O. Prokofyev, G. Rakness, L. Ristori, B. Schneider, E. Sexton-Kennedy, A. Soha, W. J. Spalding, L. Spiegel, S. Stoynev, J. Strait, N. Strobbe, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, C. Vernieri, M. Verzocchi, R. Vidal, M. Wang, H. A. Weber, A. Whitbeck, D. Acosta, P. Avery, P. Bortignon, D. Bourilkov, A. Brinkerhoff, A. Carnes, M. Carver, D. Curry, R. D. Field, I. K. Furic, S. V. Gleyzer, B. M. Joshi, J. Konigsberg, A. Korytov, K. Kotov, P. Ma, K. Matchev, H. Mei, G. Mitselmakher, K. Shi, D. Sperka, N. Terentyev, L. Thomas, J. Wang, S. Wang, J. Yelton, Y. R. Joshi, S. Linn, P. Markowitz, J. L. Rodriguez, A. Ackert, T. Adams, A. Askew, S. Hagopian, V. Hagopian, K. F. Johnson, T. Kolberg, G. Martinez, T. Perry, H. Prosper, A. Saha, A. Santra, R. Yohay, M. M. Baarmand, V. Bhopatkar, S. Colafranceschi, M. Hohlmann, D. Noonan, T. Roy, F. Yumiceva, M. R. Adams, L. Apanasevich, D. Berry, R. R. Betts, R. Cavanaugh, X. Chen, O. Evdokimov, C. E. Gerber, D. A. Hangal, D. J. Hofman, K. Jung, J. Kamin, I. D. Sandoval Gonzalez, M. B. Tonjes, H. Trauger, N. Varelas, H. Wang, Z. Wu, J. Zhang, B. Bilki, W. Clarida, K. Dilsiz, S. Durgut, R. P. Gandrajula, M. Haytmyradov, V. Khristenko, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, H. Ogul, Y. Onel, F. Ozok, A. Penzo, C. Snyder, E. Tiras, J. Wetzel, K. Yi, B. Blumenfeld, A. Cocoros, N. Eminizer, D. Fehling, L. Feng, A. V. Gritsan, P. Maksimovic, J. Roskes, U. Sarica, M. Swartz, M. Xiao, C. You, A. Al-bataineh, P. Baringer, A. Bean, S. Boren, J. Bowen, J. Castle, S. Khalil, A. Kropivnitskaya, D. Majumder, W. Mcbrayer, M. Murray, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, A. Ivanov, K. Kaadze, Y. Maravin, A. Mohammadi, L. K. Saini, N. Skhirtladze, F. Rebassoo, D. Wright, C. Anelli, A. Baden, O. Baron, A. Belloni, S. C. Eno, Y. Feng, C. Ferraioli, N. J. Hadley, S. Jabeen, G. Y. Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, J. Salfeld-Nebgen, G. S. F. Stephans, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, J. Hiltbrand, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, J. Dolen, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. Orimoto, R. Teixeira De Lima, D. Trocino, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M. H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, B. Liu, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, S. Folgueras, L. Gutay, M. K. Jha, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, N. Parashar, J. Stupak, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, K. A. Ulmer, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Libeiro, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, T. Ruggles, A. Savin, N. Smith, W. H. Smith, D. Taylor, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2023
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25. Mining Task-Specific Lines of Code Counters

Author: Miroslaw Ochodek, Krzysztof Durczak, Jerzy Nawrocki, and Miroslaw Staron
Subjects: Software measurement, software size, lines of code, LOC, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract: Context: Lines of code (LOC) is a fundamental software code measure that is widely used as a proxy for software development effort or as a normalization factor in many other software-related measures (e.g., defect density). Unfortunately, the problem is that it is not clear which lines of code should be counted: all of them or some specific ones depending on the project context and task in mind? Objective: To design a generator of task-specific LOC measures and their counters mined directly from data that optimize the correlation between the LOC measures and variables they proxy for (e.g., code-review duration). Method: We use Design Science Research as our research methodology to build and validate a generator of task-specific LOC measures and their counters. The generated LOC counters have a form of binary decision trees inferred from historical data using Genetic Programming. The proposed tool was validated based on three tasks, i.e., mining LOC measures to proxy for code readability, number of assertions in unit tests, and code-review duration. Results: Task-specific LOC measures showed a “strong” to “very strong” negative correlation with code-readability score (Kendall’s $\tau $ ranging from −0.83 to −0.76) compared to “weak” to “strong” negative correlation for the best among the standard LOC measures ( $\tau $ ranging from −0.36 to −0.13). For the problem of proxying for the number of assertions in unit tests, correlation coefficients were also higher for task-specific LOC measures by ca. 11% to 21% ( $\tau $ ranged from 0.31 to 0.34). Finally, task-specific LOC measures showed a stronger correlation with code-review duration than the best among the standard LOC measures ( $\tau $ = 0.31, 0.36, and 0.37 compared to 0.11, 0.08, 0.16, respectively). Conclusions: Our study shows that it is possible to mine task-specific LOC counters from historical datasets using Genetic Programming. Task-specific LOC measures obtained that way show stronger correlations with the variables they proxy for than the standard LOC measures.
Published: 2023
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26. Dry eye parameters measured with an ocular surface analyzer in eyes after vitrectomy for vitreomacular interface disorders

Author: Zofia A Nawrocka, Karolina Dulczewska-Cichecka, Zofia Nawrocka, and Jerzy Nawrocki
Subjects: dry eye, osa, vitrectomy, Ophthalmology, RE1-994
Abstract: Purpose: Dry eye disease (DED) might be caused by multiple ocular surgical interventions. The aim of the study was to estimate the extent of DED in patients undergoing core vitrectomy for vitreoretinal interface disorders. Methods: In this prospective observational study, we included patients with 12 months of follow-up after vitrectomy. The following data were collected as controls: age, sex, best-corrected visual acuity before and after surgery, and phakic status. In OSA (ocular surface analysis), the following parameters were evaluated: NIBUT (non-invasive tear break-up time), sltDear (thickness of the lipid layer), Meibomian gland (MGD) loss, and the height of tear meniscus. Shapiro–Wilk test, Wilcoxon rank-sum test, and Mann–Whitney U tests were used for statistical analysis. Results: We evaluated 48 eyes of 24 patients (10 men, 14 women; 64.63 ± 14.10 years) 1 year after vitrectomy. From the analyzed ocular surface parameters, NIBUT was significantly lower in operated versus non-operated eyes (P = 0.048). The higher the level of difference in MGD loss between both eyes, the higher the level of difference in NIBUT between both eyes (rs = 0.47, P = 0.032). Conclusion: NIBUT levels were still decreased 12 months after vitrectomy. Patients with more pronounced MGD loss or decreased NIBUT levels in the fellow eye were more likely to experience such disorders. The tear meniscus height was lower in patients undergoing surgery for retinal detachment than in those with vitreoretinal disorders. This might allow the suggestion to include artificial tears in pre- and post-operative care in vitrectomized eyes.
Published: 2023
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27. The Impact of the COVID-19 Pandemic on the Number of Cancer Patients and Radiotherapy Procedures in the Warmia and Masuria Voivodeship

Author: Marcin Kurowicki, Karolina Osowiecka, Barbara Szostakiewicz, Monika Rucińska, and Sergiusz Nawrocki
Subjects: cancer, radiotherapy, COVID-19, healthcare, pandemic, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: (1) Background: It was suspected that the COVID-19 pandemic would negatively affect health care, including cancer treatment. The aim of the study was to assess the impact of the COVID-19 pandemic on the number of radiotherapy procedures and patients treated with radical and palliative radiotherapy in Poland. (2) Methods: The study was carried out in Warmia and Masuria voivodeship. The number of procedures and treated patients one year before and in the first year of the COVID-19 pandemic were compared. (3) Results: In the first year of the COVID-19 pandemic, the number of radiotherapy procedures and cancer patients treated with radiotherapy in Warmia and Masuria voivodeship in Poland was stable compared to the period before the pandemic. The COVID-19 pandemic has not affected the ratio of palliative to radical procedures. The percentage of ambulatory and hostel procedures significantly increased with the reduction of inpatient care in the first year of the COVID-19 pandemic. (4) Conclusion: No significant decrease in patients treated with radiotherapy during the first year of the pandemic in Warmia and Masuria voivodeship in Poland could indicate the rapid adaptation of radiotherapy centers to the pandemic situation. Future studies should be carried out to monitor the situation because the adverse effects of the pandemic may be delayed.
Published: 2023
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28. Bone Remodeling of Maxilla after Retraction of Incisors during Orthodontic Treatment with Extraction of Premolars Based on CBCT Study: A Systematic Review

Author: Anna Ewa Kuc, Jacek Kotuła, Jakub Nawrocki, Maria Kulgawczyk, Beata Kawala, Joanna Lis, and Michał Sarul
Subjects: bone remodeling, retraction, orthodontic treatment, CBCT study, Medicine
Abstract: Background: Incisor retraction is often a crucial phase in ongoing orthodontic treatment, with significant implications for alveolar remodeling mechanisms. There are two prevailing theories which seek to explain this. According to the first, teeth move with the bone, while according to the second, teeth move within the bone. This systematic review seeks to assess morphometric changes in the maxillary alveolar process resulting from incisor retraction following premolar extraction and to evaluate the potential for bone remodeling associated with orthodontic movement. Methods: The study was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The following electronic databases were searched: PubMed, Google Scholar, Web of Science EMBASE and the Cochrane Central Register of Controlled Trials. The databases were searched using the following keywords: “Bone remodeling and retraction of incisors”, “Alveolar bone and incisor retraction”, “Bone thickness and incisor retraction”, and “Bone changes and orthodontic treatment”. Search filters were utilized to identify relevant papers and articles written in English and published during the last 10 years. Based on the information provided in their abstracts, papers and articles were selected according to the following criteria: randomized clinical trials (RCTs), controlled clinical prospective trials (CCTs), and retrospective studies. Articles unrelated to the study’s scope or failing to meet inclusion criteria were excluded. These generally comprised individual case reports, case series reports, literature reviews, experimental studies, studies with limited data (including conference abstracts and journal writings), studies involving an unrepresentative group of patients (less than 10 patients), studies concerning patients with syndromes, and animal experiments. The remaining articles which were deemed relevant underwent comprehensive reference review and such journals as the American Journal of Orthodontics, Dentofacial Orthopedics, International Orthodontics, Journal of Clinical Orthodontics, and Angle Orthodontist were manually searched. Results: Seven articles meeting the inclusion criteria articles were selected for final evaluation, with a total of 284 participants, including 233 women and 51 men. During the analysis of the results included in the publications, a lack of homogeneity was observed, rendering a reliable statistical analysis and heterogeneity assessment unobtainable. Noteworthy disparities in methodologies and measurements posed a risk of drawing inappropriate conclusions. Consequently, emphasis was placed on qualitative analysis, emphasizing the need for standardization in future studies of a similar nature, to enable valid and comparable analyses. Conclusions: The research findings incorporated in this review demonstrate that significant bone loss occurs because of incisor retraction, which diminishes distance between the bone surface and the root surface on the palatal aspect. The magnitude of this change may vary, contingent upon both the extent of incisor displacement and alterations in their inclination, thereby affecting the positioning of the root tips. This change is significantly higher in adults than in growing adolescents. The rationale behind this assertion lies in the widely recognized phenomenon of declining cellular activity with advancing age. The decrease in the speed and intensity of cellular changes may explain the diminished capacity for remodeling as patient age increases. There is ongoing discourse regarding alterations in the volume of bone on the labial aspect of the alveolar process. Further research is necessary to measure whether bone remodeling during orthodontic movement is contingent upon other factors, such as the speed and biomechanics of retraction, the level of applied orthodontic force, and the patient age.
Published: 2024
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29. Transient Photocurrent Response in a Perovskite Single Crystal‐Based Photodetector: A Case Study on the Role of Electrode Spacing and Bias

Author: Apurba Mahapatra, Vishnu Anilkumar, Jan Nawrocki, Siddhi Vinayak Pandey, Rohit D. Chavan, Pankaj Yadav, and Daniel Prochowicz
Subjects: lead halide perovskite, photodetectors, recombination, single crystals, transient photocurrent, Electric apparatus and materials. Electric circuits. Electric networks, TK452-454.4, Physics, QC1-999
Abstract: Abstract Transient photocurrent is a widely applied characterization technique to probe the charge‐carrier photogeneration and extraction dynamics in perovskite optoelectronic devices. Despite the large number of studies on the properties of perovskite single‐crystals (SCs) photodetectors (PDs), the underlying mechanism that governs the spectral line shape of transient photocurrent is not fully understood. Here, methylammonium lead bromide (MAPbBr3)SC based PDs are used to study the effect of different electrode spacing and bias on the transient photocurrent response under blue and green light irradiation. The observed differences in the spectral line shape of the transient photocurrent are explained using three‐step carrier transport model, which reveals the occurrence of carrier trapping and a recombination process in MAPbBr3 SC. The findings are further corroborated by intensity‐dependent photocurrent and impedance spectroscopy analysis of the resulting PDs. This work provides a basic insight into the origin of the different behavior of transient photocurrent response under variable electrode distance, bias, and irradiance light, which is expected to help to further understand and optimize the performance of perovskite based PDs.
Published: 2023
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30. Racial/ethnic disparities in the cause of death among patients with prostate cancer in the United States from 1995 to 2019: a population-based retrospective cohort studyResearch in context

Author: Hongmei Zeng, Mengyuan Xu, Yingwei Xie, Sergiusz Nawrocki, Jakub Morze, Xianhui Ran, Tianhao Shan, Changfa Xia, Yixin Wang, Lingeng Lu, Xue Qin Yu, Catarina Machado Azeredo, John S. Ji, Xiaomei Yuan, Katherine Curi-Quinto, Yuexin Liu, Bingsheng Liu, Tao Wang, Hao Ping, and Edward L. Giovannucci
Subjects: Prostate cancer, Racial/ethnic disparities, Cause-specific death, The United States, Medicine (General), R5-920
Abstract: Summary: Background: Racial/ethnic disparities in prostate cancer are reported in the United States (US). However, long-term trends and contributors of racial/ethnic disparities in all-cause and cause-specific death among patients with prostate cancer remain unclear. We analysed the trends and contributors of racial/ethnic disparities in prostate cancer survivors according to the cause of death in the US over 25 years. Methods: In this retrospective, population-based longitudinal cohort study, we identified patients diagnosed with first primary prostate cancer between 1995 and 2019, with follow-up until Dec 31, 2019, using population-based cancer registries’ data from the Surveillance, Epidemiology, and End Results (SEER) Program. We calculated the cumulative incidence of death for each racial/ethnic group (Black, white, Hispanic, Asian or Pacific Islander [API], and American Indian or Alaska Native [AI/AN] people), by diagnostic period and cause of death. We quantified absolute disparities using rate changes for the 5-year cumulative incidence of death between racial/ethnic groups and diagnostic periods. We estimated relative (Hazard ratios [HR]) racial/ethnic disparities and the percentage of potential factors contributed to racial/ethnic disparities using Cox regression models. Findings: Despite a decreasing trend in the cumulative risk of death across five racial/ethnic groups, AI/AN and Black patients consistently had the highest rate of death between 1995 and 2019 with an adjusted HR of 1.48 (1.40–1.58) and 1.40 (1.38–1.42) respectively. The disparities in all-cause mortality between AI/AN and white patients increased over time, with adjusted HR 1.32 (1.17–1.49) in 1995–1999 and 1.95 (1.53–2.49) in 2015–2019. Adjustment of stage at diagnosis, initial treatment, tumor grade, and household income explained 33% and 24% of the AI/AN-white and Black-white disparities in all-cause death among patients with prostate cancer. Interpretation: The enduring racial/ethnic disparities in patients with prostate cancer, call for new interventions to eliminate health disparities. Our study provides important evidence and ways to address racial/ethnic inequality. Funding: National Key R&D Program of China, National Natural Science Foundation of China, Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, the Open Research Fund from Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Key Projects of Philosophy and Social Sciences Research, Ministry of Education of China.
Published: 2023
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31. Air phyto-cleaning by an urban meadow – Filling the winter gap

Author: A. Nawrocki, R. Popek, P. Sikorski, M. Wińska-Krysiak, Ch.Y. Zhu, and A. Przybysz
Subjects: Air pollution, Herbaceous plants, Lawn, Particulate matter (PM), Phyto-cleaning, Urban greenery, Ecology, QH540-549.5
Abstract: Urban areas are characterised by polluted air which endangers the health and quality of life of city dwellers. Among the dangerous air contaminants is particulate matter (PM) and one of the main sources of PM in urban areas is road traffic. Studies have already shown that the air can be phyto-cleaned by plants, especially trees and shrubs. However, for safety reasons, planting trees and shrubs in some places is problematic, e.g. close to roads. These locations are usually occupied by lawns, which are plant communities of low ecological value. Unfortunately, too little attention has been paid so far to urban meadows. Therefore, this study (i) investigated for the first time the phyto-cleaning potential of an urban meadow all year round, including autumn–winter period, and (ii) compared the efficiency and mechanisms of PM phyto-cleaning by an urban meadow and lawn during the vegetative season. Plant material was harvested from urban meadow (in June, August, November and March) and lawns (in June and August) located by a busy road in Warsaw (Poland). PM was analysed in two categories (surface PM and in-wax PM) and two size fractions (fine: 0.2–2.5 µm, coarse: 2.5–10 µm). The results obtained suggested that accumulation of PM by urban meadow is possible even out of vegetative season. In autumn and winter, even though the meadow plants were physiologically not active, they still participated in air phyto-cleaning. Urban meadow phyto-cleaned air most effectively in summer when the vegetation was fully developed, and least effectively in autumn. During the vegetative season, the urban meadow accumulated more PM than lawns, mostly due to the greater height and complex structure. Therefore, urban meadow would appear to offer an promising solution to problem of phyto-cleaning of urban air in the immediate vicinity of roads throughout the year.
Published: 2023
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32. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author: The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, C. Goetzmann, P. Juillot, A.-C. Le Bihan, P. Van Hove, S. Gadrat, S. Beauceron, N. Beaupere, G. Boudoul, S. Brochet, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, M. Vander Donckt, P. Verdier, S. Viret, Z. Tsamalaidze, C. Autermann, S. Beranek, B. Calpas, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, K. Klein, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, K. Padeken, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, S. Thüer, M. Weber, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. Haller, K. Heine, R. S. Höing, G. Kaussen, H. Kirschenmann, R. Klanner, R. Kogler, J. Lange, I. Marchesini, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, J. Sibille, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, D. Troendle, L. Vanelderen, C. Barth, C. Baus, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, A. Kornmayer, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, S. Röcker, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Anagnostou, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, A. Markou, C. Markou, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, E. Stiliaris, X. Aslanoglou, I. Evangelou, G. Flouris, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, E. Paradas, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, B. Radics, F. Sikler, V. Veszpremi, G. Vesztergombi, A. J. Zsigmond, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, M. Mittal, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, P. Saxena, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, K. Chatterjee, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, A. Modak, S. Mukherjee, D. Roy, S. Sarkar, M. Sharan, A. Abdulsalam, D. Dutta, S. Kailas, V. Kumar, A. K. Mohanty, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, R. M. Chatterjee, S. Ganguly, S. Ghosh, M. Guchait, A. Gurtu, G. Kole, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Grunewald, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, R. Travaglini, S. Albergo, M. Chiorboli, S. 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Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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33. Invited review: Sensor technologies for real-time monitoring of the rumen environment

Author: Chan Su Han, Upinder Kaur, Huiwen Bai, Barbara Roqueto dos Reis, Robin White, Robert A. Nawrocki, Richard M. Voyles, Min Gyu Kang, and Shashank Priya
Subjects: biosensor, rumen, precision livestock farming, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract: ABSTRACT: Quantifying digestive and fermentative processes within the rumen environment has been the subject of decades of research; however, our existing research methodologies preclude time-sensitive and spatially explicit investigation of this system. To better understand the temporal and spatial dynamics of the rumen environment, real-time and in situ monitoring of various chemical and physical parameters in the rumen through implantable microsensor technologies is a practical solution. Moreover, such sensors could contribute to the next generation of precision livestock farming, provided sufficient wireless data networking and computing systems are incorporated. In this review, various microsensor technologies applicable to real-time metabolic monitoring for ruminants are introduced, including the detection of parameters for rumen metabolism, such as pH, temperature, histamine concentrations, and volatile fatty acid concentrations. The working mechanisms and requirements of the sensors are summarized with respect to the selected target parameters. Lastly, future challenges and perspectives of this research field are discussed.
Published: 2022
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34. Soluble biomarkers to predict clinical outcomes in non-small cell lung cancer treated by immune checkpoints inhibitors

Author: Julien Ancel, Valérian Dormoy, Béatrice Nawrocki Raby, Véronique Dalstein, Anne Durlach, Maxime Dewolf, Christine Gilles, Myriam Polette, and Gaëtan Deslée
Subjects: liquid biopsy, soluble biomarkers, immunotherapy, non-small cell lung cancer (NSCLC), neutrophil lymphocyte ratio (NLR), circulating tumor (ctDNA), Immunologic diseases. Allergy, RC581-607
Abstract: Lung cancer remains the first cause of cancer-related death despite many therapeutic innovations, including immune checkpoint inhibitors (ICI). ICI are now well used in daily practice at late metastatic stages and locally advanced stages after a chemo-radiation. ICI are also emerging in the peri-operative context. However, all patients do not benefit from ICI and even suffer from additional immune side effects. A current challenge remains to identify patients eligible for ICI and benefiting from these drugs. Currently, the prediction of ICI response is only supported by Programmed death-ligand 1 (PD-L1) tumor expression with perfectible results and limitations inherent to tumor-biopsy specimen analysis. Here, we reviewed alternative markers based on liquid biopsy and focused on the most promising biomarkers to modify clinical practice, including non-tumoral blood cell count such as absolute neutrophil counts, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, and derived neutrophil to lymphocyte ratio. We also discussed soluble-derived immune checkpoint-related products such as sPD-L1, circulating tumor cells (detection, count, and marker expression), and circulating tumor DNA-related products. Finally, we explored perspectives for liquid biopsies in the immune landscape and discussed how they could be implemented into lung cancer management with a potential biological–driven decision.
Published: 2023
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35. Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis

Author: Xinkang Wang, Qiu Li, Fuyong Du, Neetu Shukla, Andrea R. Nawrocki, and Madhu Chintala
Subjects: anticoagulants, factor xi, thrombosis, models, animal, pharmacology, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhibitor. Objective Milvexian's antithrombotic efficacy was characterized in a rabbit arteriovenous (AV) shunt model of venous thrombosis and compared with the factor Xa inhibitor apixaban and the direct thrombin inhibitor dabigatran. Methods The AV shunt model of thrombosis was conducted in anesthetized rabbits. Vehicle or drugs were administered as intravenous bolus plus a continuous infusion. Thrombus weight was the primary efficacy endpoint. Ex vivo activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT) were measured as the pharmacodynamic responses. Results Milvexian dose dependently reduced thrombus weights by 34.3 ± 7.9, 51.6 ± 6.8 (p
Published: 2023
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36. Current Landscape of Immune Checkpoint Inhibitors for Metastatic Urothelial Carcinoma: Is There a Role for Additional T-Cell Blockade?

Author: Vanessa Ogbuji, Irasema C. Paster, Alejandro Recio-Boiles, Jennifer S. Carew, Steffan T. Nawrocki, and Juan Chipollini
Subjects: urothelial carcinoma, immune checkpoint inhibitor, bladder cancer, PD-1, CTLA-4, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Urothelial carcinoma (UC) is the most common form of bladder cancer (BC) and is the variant with the most immunogenic response. This makes urothelial carcinoma an ideal candidate for immunotherapy with immune checkpoint inhibitors. Key immune checkpoint proteins PD-1 and CTLA-4 are frequently expressed on T-cells in urothelial carcinoma. The blockade of this immune checkpoint can lead to the reactivation of lymphocytes and augment the anti-tumor immune response. The only immune checkpoint inhibitors that are FDA-approved for metastatic urothelial carcinoma target the programmed death-1 receptor and its ligand (PD-1/PD-L1) axis. However, the overall response rate and progression-free survival rates of these agents are limited in this patient population. Therefore, there is a need to find further immune-bolstering treatment combinations that may positively impact survival for patients with advanced UC. In this review, the current immune checkpoint inhibition treatment landscape is explored with an emphasis on combination therapy in the form of PD-1/PD-L1 with CTLA-4 blockade. The investigation of the current literature on immune checkpoint inhibition found that preclinical data show a decrease in tumor volumes and size when PD-1/PD-L1 is blocked, and similar results were observed with CTLA-4 blockade. However, there are limited investigations evaluating the combination of CTLA-4 and PD-1/PD-L1 blockade. We anticipate this review to provide a foundation for a deeper experimental investigation into combination immune checkpoint inhibition therapy in metastatic urothelial carcinoma.
Published: 2023
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37. HER2 Alterations in Non-Small Cell Lung Cancer: Biologico-Clinical Consequences and Interest in Therapeutic Strategies

Author: Emma Loeffler, Julien Ancel, Véronique Dalstein, Gaëtan Deslée, Myriam Polette, and Béatrice Nawrocki-Raby
Subjects: non-small cell lung cancer, oncogenic drivers, HER2 alterations, anti-HER2 targeted therapy, Science
Abstract: Lung cancer stands as the first cause of death by cancer in the world. Despite the improvement in patients’ outcomes in the past decades through the development of personalized medicine approaches, a substantial portion of patients remains ineligible for targeted therapies due to the lack of a “druggable” molecular target. HER2, a receptor tyrosine kinase member of the EGFR/ErbB family, is known to show oncogenic properties. In this review, we focus on the different HER2 dysregulation mechanisms that have been observed in non-small cell lung cancer (NSCLC): gene mutation, gene amplification, protein overexpression and protein hyper-phosphorylation, the latter suggesting that HER2 dysregulation can occur independently of any molecular aberration. These HER2 alterations inevitably have consequences on tumor biology. Here, we discuss how they are not only involved in abnormal proliferation and survival of cancer cells but also potentially in increased angiogenic properties, mesenchymal features and tumor immune escape. Finally, we review the impact of these HER2 alterations in various therapeutic approaches. While standard chemotherapy and groundbreaking immunotherapy seem rather ineffective for HER2-altered NSCLCs, the development of HER2-targeted therapies such as tyrosine kinase inhibitors, anti-HER2 antibodies and especially antibody–drug conjugates could provide new hopes for patients.
Published: 2023
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38. Morphological Evaluation of the Incisive Canal in the Aspect of the Diagnosis and Planning of Orthodontic Treatment—CBCT Study

Author: Anna Ewa Kuc, Jacek Kotuła, Jakub Nawrocki, Ewa Szeląg, Beata Kawala, Joanna Lis, and Michał Sarul
Subjects: anatomy, CBCT, root resorption, incisive canal, nasopalatine canal, retraction, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract: Background: Understanding the anatomy of the incisive canal is crucial for effective diagnosis and treatment planning in clinical orthodontics. This is because, during orthodontic tooth movement, there is a risk of contact between the roots of the upper central incisors and the incisive canal. Objective: The aim of this study was to assess the anatomical variability of the incisive canal using cone beam computed tomography (CBCT), as well as to evaluate its correlation with age, sex, and the position of the maxillary central incisors. There are only a few studies on this topic. Materials and methods: We analysed CBCT data from 67 patients aged from 13 to 49 years. This study was conducted at the Wroclaw Medical University. Measurements were performed twice by two independent researchers, and intra-observer error and correlation were calculated. The mean difference between the first and second observations and between observers was also assessed. We examined the dimensions of the incisive canal and its relationship to the roots of the upper central incisors in relation to age and gender. Results: Our study results revealed a significant correlation between the width and length of the incisive canal. Males exhibited a significantly greater canal length at the lowest point of the incisive canal on the palatal wall. Additionally, males had wider canals compared to females. The analysis of canal width and distance between the most mesial point of the root and the line passing through the most anterior point of the incisive canal showed a negative correlation in all age groups of men. The analysis of incisal inclination and incisal canal inclination showed a very strong relationship, especially in the age group of 13 to 20 years. Several potential risk groups of contact between the roots of central incisors and the incisive canal have been identified based on their structure and the planned incisors’ orthodontic movement. Conclusions and implications: Knowledge of the anatomy of the incisive canal and the use of 3D imaging in high-risk patients can prevent resorption of the incisor root by considering the individual anatomical conditions of the patient when planning orthodontic tooth movement. We recommend performing a CBCT scan before starting orthodontic treatment in the case of moderate and significant retraction of the incisors, or a significant change in their inclination due to the wide anatomical diversity of the incisive canal, especially in adult patients.
Published: 2023
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39. Erratum to: Measurement of the top quark mass with lepton+jets final states using pp collisions at $$\sqrt{s} = 13\,\hbox {TeV}$$ s = 13 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hrubec, M. Jeitler, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, Luigi Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, M. A. Mahmoud, Elgammal A. Mohamed, E. Salama, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. Ochando, G. Ortona, P. Paganini, P. Pigard, R. Salerno, J. B. Sauvan, Y. Sirois, A. G. Stahl Leiton, Y. Yilmaz, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, X. Coubez, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, M. Jansová, P. Juillot, A.-C. Le Bihan, N. Tonon, P. Van Hove, S. Gadrat, S. Beauceron, C. Bernet, G. Boudoul, N. Chanon, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, L. Finco, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, F. Lagarde, I. B. Laktineh, H. Lattaud, M. Lethuillier, L. Mirabito, A. L. Pequegnot, S. Perries, A. Popov, V. Sordini, M. Vander Donckt, S. Viret, S. Zhang, T. Toriashvili, Z. Tsamalaidze, C. Autermann, L. Feld, M. K. Kiesel, K. Klein, M. Lipinski, M. Preuten, M. P. Rauch, C. Schomakers, J. Schulz, M. Teroerde, B. Wittmer, V. Zhukov, A. Albert, D. Duchardt, M. Endres, M. Erdmann, S. Erdweg, T. Esch, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, S. Knutzen, M. Merschmeyer, A. Meyer, P. Millet, S. Mukherjee, T. Pook, M. Radziej, H. Reithler, M. Rieger, F. Scheuch, D. Teyssier, S. Thüer, G. Flügge, B. Kargoll, T. Kress, A. Künsken, T. Müller, A. Nehrkorn, A. Nowack, C. Pistone, O. Pooth, A. Stahl, M. Aldaya Martin, T. Arndt, C. Asawatangtrakuldee, I. Babounikau, K. Beernaert, O. Behnke, U. Behrens, A. Bermúdez Martínez, D. Bertsche, A. A. Bin Anuar, K. Borras, V. Botta, A. Campbell, P. Connor, C. Contreras-Campana, F. Costanza, V. Danilov, A. De Wit, C. Diez Pardos, D. Domínguez Damiani, G. Eckerlin, D. Eckstein, T. Eichhorn, A. Elwood, E. Eren, E. Gallo, J. Garay Garcia, A. Geiser, J. M. Grados Luyando, A. Grohsjean, P. Gunnellini, M. Guthoff, A. Harb, J. Hauk, H. Jung, M. Kasemann, J. Keaveney, C. Kleinwort, J. Knolle, I. Korol, D. Krücker, W. Lange, A. Lelek, T. Lenz, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, A. B. Meyer, M. Meyer, M. Missiroli, G. Mittag, J. Mnich, A. Mussgiller, S. K. Pflitsch, D. Pitzl, A. Raspereza, M. Savitskyi, P. Saxena, C. 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Ellison, J. W. Gary, S. M. A. Ghiasi Shirazi, G. Hanson, G. Karapostoli, E. Kennedy, F. Lacroix, O. R. Long, M. Olmedo Negrete, M. I. Paneva, W. Si, L. Wang, H. Wei, S. Wimpenny, B. R. Yates, J. G. Branson, S. Cittolin, M. Derdzinski, R. Gerosa, D. Gilbert, B. Hashemi, A. Holzner, D. Klein, G. Kole, V. Krutelyov, J. Letts, M. Masciovecchio, D. Olivito, S. Padhi, M. Pieri, M. Sani, V. Sharma, S. Simon, M. Tadel, A. Vartak, S. Wasserbaech, J. Wood, F. Würthwein, A. Yagil, G. Zevi Della Porta, N. Amin, R. Bhandari, J. Bradmiller-Feld, C. Campagnari, M. Citron, A. Dishaw, V. Dutta, M. Franco Sevilla, L. Gouskos, R. Heller, J. Incandela, A. Ovcharova, H. Qu, J. Richman, D. Stuart, I. Suarez, J. Yoo, D. Anderson, A. Bornheim, J. Bunn, J. M. Lawhorn, H. B. Newman, T. Q. Nguyen, C. Pena, M. Spiropulu, J. R. Vlimant, R. Wilkinson, S. Xie, Z. Zhang, R. Y. Zhu, M. B. Andrews, T. Ferguson, T. Mudholkar, M. Paulini, J. Russ, M. Sun, H. Vogel, I. Vorobiev, M. Weinberg, J. P. Cumalat, W. T. Ford, F. Jensen, A. Johnson, M. Krohn, S. Leontsinis, E. MacDonald, T. Mulholland, K. Stenson, K. A. Ulmer, S. R. Wagner, J. Alexander, J. Chaves, Y. Cheng, J. Chu, A. Datta, K. Mcdermott, N. Mirman, J. R. Patterson, D. Quach, A. Rinkevicius, A. Ryd, L. Skinnari, L. Soffi, S. M. Tan, Z. Tao, J. Thom, J. Tucker, P. Wittich, M. Zientek, S. Abdullin, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, A. Apyan, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, G. Bolla, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, M. Cremonesi, J. Duarte, V. D. Elvira, J. Freeman, Z. Gecse, E. Gottschalk, L. Gray, D. Green, S. Grünendahl, O. Gutsche, J. Hanlon, R. M. Harris, S. Hasegawa, J. Hirschauer, Z. Hu, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, B. Klima, M. J. Kortelainen, B. Kreis, S. Lammel, D. Lincoln, R. Lipton, M. Liu, T. Liu, R. Lopes De Sá, J. Lykken, K. Maeshima, N. Magini, J. M. Marraffino, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, V. O’Dell, K. Pedro, O. Prokofyev, G. Rakness, L. Ristori, A. Savoy-Navarro, B. Schneider, E. Sexton-Kennedy, A. Soha, W. J. Spalding, L. Spiegel, S. Stoynev, J. Strait, N. Strobbe, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, C. Vernieri, M. Verzocchi, R. Vidal, M. Wang, H. A. Weber, A. Whitbeck, W. Wu, D. Acosta, P. Avery, P. Bortignon, D. Bourilkov, A. Brinkerhoff, A. Carnes, M. Carver, D. Curry, R. D. Field, I. K. Furic, S. V. Gleyzer, B. M. Joshi, J. Konigsberg, A. Korytov, K. Kotov, P. Ma, K. Matchev, H. Mei, G. Mitselmakher, K. Shi, D. Sperka, N. Terentyev, L. Thomas, J. Wang, S. Wang, J. Yelton, Y. R. Joshi, S. Linn, P. Markowitz, J. L. Rodriguez, A. Ackert, T. Adams, A. Askew, S. Hagopian, V. Hagopian, K. F. Johnson, T. Kolberg, G. Martinez, T. Perry, H. Prosper, A. Saha, A. Santra, R. Yohay, M. M. Baarmand, V. Bhopatkar, S. Colafranceschi, M. Hohlmann, D. Noonan, T. Roy, F. Yumiceva, M. R. Adams, L. Apanasevich, D. Berry, R. R. Betts, R. Cavanaugh, X. Chen, S. Dittmer, O. Evdokimov, C. E. Gerber, D. A. Hangal, D. J. Hofman, K. Jung, J. Kamin, I. D. Sandoval Gonzalez, M. B. Tonjes, N. Varelas, H. Wang, Z. Wu, J. Zhang, B. Bilki, W. Clarida, K. Dilsiz, S. Durgut, R. P. Gandrajula, M. Haytmyradov, V. Khristenko, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, H. Ogul, Y. Onel, F. Ozok, A. Penzo, C. Snyder, E. Tiras, J. Wetzel, K. Yi, B. Blumenfeld, A. Cocoros, N. Eminizer, D. Fehling, L. Feng, A. V. Gritsan, W. T. Hung, P. Maksimovic, J. Roskes, U. Sarica, M. Swartz, M. Xiao, C. You, A. Al-bataineh, P. Baringer, A. Bean, J. F. Benitez, S. Boren, J. Bowen, J. Castle, S. Khalil, A. Kropivnitskaya, D. Majumder, W. Mcbrayer, M. Murray, C. Rogan, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, A. Ivanov, K. Kaadze, Y. Maravin, A. Modak, A. Mohammadi, L. K. Saini, N. Skhirtladze, F. Rebassoo, D. Wright, A. Baden, O. Baron, A. Belloni, S. C. Eno, Y. Feng, C. Ferraioli, N. J. Hadley, S. Jabeen, G. Y. Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, G. Bauer, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. Orimoto, R. Teixeira De Lima, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M. H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, T. Y. Ling, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, J. Salfeld-Nebgen, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, L. Gutay, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, J. Dolen, N. Parashar, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J. D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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40. Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism

Author: Trace M. Jones, Claudia M. Espitia, Aikseng Ooi, Julie E. Bauman, Jennifer S. Carew, and Steffan T. Nawrocki
Subjects: Cytology, QH573-671
Abstract: Abstract Patients with late-stage and human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) continue to have a very poor prognosis. The development of more effective novel therapies that improve overall survival and overcome drug resistance is an urgent priority. Here we report that HNSCC tumors significantly overexpress NEDD8 and exhibit high sensitivity to the first-in-class NEDD8-activating enzyme (NAE) inhibitor pevonedistat. Additional studies established that disruption of NEDD8-mediated protein turnover with pevonedistat dramatically augmented cisplatin-induced DNA damage and apoptosis in HNSCC models. Further analysis revealed that the specific pevonedistat target CUL4A played an essential role in driving the synergy of the pevonedistat and cisplatin combination. Targeted inhibition of CUL4A resulted in significant downregulation in Damage Specific DNA binding protein 2 (DDB2), a DNA-damage recognition protein that promotes nucleotide excision repair and resistance to cisplatin. Silencing of CUL4A or DDB2 enhanced cisplatin-induced DNA damage and apoptosis in a manner similar to that of pevonedistat demonstrating that targeted inhibition of CUL4A may be a novel approach to augment cisplatin therapy. Administration of pevonedistat to mice bearing HNSCC tumors significantly decreased DDB2 expression in tumor cells, increased DNA damage and potently enhanced the activity of cisplatin to yield tumor regression and long-term survival of all animals. Our findings provide strong rationale for clinical investigation of CUL4A inhibition with pevonedistat as a novel strategy to augment the efficacy of cisplatin therapy for patients with HNSCC and identify loss of DDB2 as a key pharmacodynamic mediator controlling sensitivity to this regimen.
Published: 2022
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41. Innovativeness in energy companies in developing economies: Determinants, evaluation and comparative analysis using the example of Poland

Author: Tomasz L. Nawrocki and Izabela Jonek-Kowalska
Subjects: Potential and resultant innovativeness, Evaluation of innovativeness in energy companies, Energy in developing economies, Management. Industrial management, HD28-70, Business, HF5001-6182
Abstract: Energy and the energy transition associated with its operation requires the creation and implementation of innovations, without which effective changes in the energy balance and greenhouse gas emissions will not be possible. This is particularly important in emerging and developing economies, which are often unable to meet modern environmental requirements. Various approaches to assessing innovation are proposed in research and literature. Nevertheless, there is a lack of holistic methods (assessing both the potential and the results of innovation), based on publicly available data and taking into account the specificity of the sector. Therefore, the objective of this article is to develop a model for evaluating innovativeness (potential and resultant) of companies in the energy sector. Additional sub-goals are: (a) using the developed model to evaluate innovativeness of seven Polish energy companies; (b) conducting a comparative analysis in terms of resultant and potential innovation for seven Polish energy companies and (c) specifying recommendations for improving the innovativeness of the examined companies and the Polish energy sector operating in a developing economy. The proposed model is based on publicly available financial data and takes into account two areas: 1. Potential innovativeness, allowing to determine the scale and type of resources supporting the creation of innovation; and 2. Resultant innovativeness, including the actual effects of pro-innovation activities. The evaluation of innovativeness in the above dimensions was carried out in 2016–2021 for seven key energy companies listed on the Warsaw Stock Exchange and operating in the Polish energy market. The study found that the best innovativeness performance was achieved by multinationals and companies with a high share of renewable sources in installed capacity and in production. In addition, the identified low degree of involvement of state-owned companies in the energy transition is not conducive to improving innovativeness and strengthening innovativeness at the national level.
Published: 2023
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42. TNFα aggravates detrimental effects of SARS-CoV-2 infection in the liver

Author: Jöran Lücke, Mikolaj Nawrocki, Josa Schnell, Nicholas Meins, Fabian Heinrich, Tao Zhang, Franziska Bertram, Morsal Sabihi, Marius Böttcher, Tom Blankenburg, Marie Pfaff, Sara Notz, Jan Kempski, Matthias Reeh, Stefan Wolter, Oliver Mann, Jakob R. Izbicki, Marc Lütgehetmann, Anna Duprée, Anastasios D. Giannou, Benjamin Ondruschka, and Samuel Huber
Subjects: SARS-CoV-2, liver, TNFa, post-mortem, Cxcl3, Cxcl8, Immunologic diseases. Allergy, RC581-607
Abstract: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus does not only lead to pulmonary infection but can also infect other organs such as the gut, the kidney, or the liver. Recent studies confirmed that severe cases of COVID-19 are often associated with liver damage and liver failure, as well as the systemic upregulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα). However, the impact these immune mediators in the liver have on patient survival during SARS-CoV-2 infection is currently unknown. Here, by performing a post-mortem analysis of 45 patients that died from a SARS-CoV-2 infection, we find that an increased expression of TNFA in the liver is associated with elevated mortality. Using publicly available single-cell sequencing datasets, we determined that Kupffer cells and monocytes are the main sources of this TNFα production. Further analysis revealed that TNFα signaling led to the upregulation of pro-inflammatory genes that are associated with an unfavorable outcome. Moreover, high levels of TNFA in the liver were associated with lower levels of interferon alpha and interferon beta. Thus, TNFα signaling in the infected SARS-CoV-2 liver correlates with reduced interferon levels and overall survival time.
Published: 2023
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43. Perspectives on dental health and oral hygiene practice from US adolescents and young adults during the COVID-19 pandemic

Author: Long Zhang, Marika Waselewski, Jack Nawrocki, Ian Williams, Margherita Fontana, and Tammy Chang
Subjects: Medicine, Science
Abstract: Background Adolescence is a critical time for adopting health behaviors which continue through adulthood. There is a lack of data regarding perspectives of US adolescents and young adults on their dental health and oral hygiene practice. Methods Adolescents and young adults, age 14–24, from MyVoice, a nationwide text message poll of youth. were asked five open-ended questions on the importance of dental health and impact of the COVID-19 pandemic. Responses were qualitatively analyzed using thematic analysis. Chi-square test was used to examine differences in experiences by demographics. Results Of 1,148 participants, 932 responded to at least one question. The mean age was 19 years. Respondents were largely male (49.5%) and non-Hispanic white (62.4%). Most (92%) respondents perceived dental health as important or somewhat important and emphasized overall dental health and hygiene (38.6%) and aesthetics (18.3%). About half (49.2%) of respondents stated they have had at least one cavity since middle school. Just over half (54.8%) reported brushing and flossing to care for their dentition. 58% visited a dentist at least every 6 months, while 38% visited a dentist less frequently or not at all. Being non-cisgender, non-Hispanic black, Hispanic, and receipt of free or reduced lunch was associated with less frequent dental visits. 44% stated COVID-19 impacted their dental health, with many mentioning scheduling difficulties or worsened dental hygiene. Conclusions Most youth in our study consider dental health important, though their oral hygiene practice may not follow ADA guidelines and self-reported dental caries are high. Dental healthcare among youth has been affected by the COVID-19 pandemic with interruption in regular dental visits and changes in hygiene habits. Re-engagement of adolescents and young adults by dental care providers via greater access to appointments and youth-centered messaging reinforcing hygiene recommendations may help youth improve dental health now and in the future.
Published: 2023

44. Transcriptomic FHITlow/pHER2high signature as a predictive factor of outcome and immunotherapy response in non-small cell lung cancer

Author: Audrey Brisebarre, Julien Ancel, Théophile Ponchel, Emma Loeffler, Adeline Germain, Véronique Dalstein, Valérian Dormoy, Anne Durlach, Gonzague Delepine, Gaëtan Deslée, Myriam Polette, and Béatrice Nawrocki-Raby
Subjects: NSCLC, FHIT, HER2, transcriptomic signature, prognosis, immunotherapy response, Immunologic diseases. Allergy, RC581-607
Abstract: IntroductionIn recent decades, the development of immunotherapy and targeted therapies has considerably improved the outcome of non-small cell lung cancer (NSCLC) patients. Despite these impressive clinical benefits, new biomarkers are needed for an accurate stratification of NSCLC patients and a more personalized management. We recently showed that the tumor suppressor fragile histidine triad (FHIT), frequently lost in NSCLC, controls HER2 receptor activity in lung tumor cells and that tumor cells from NSCLC patients harboring a FHITlow/pHER2high phenotype are sensitive to anti-HER2 drugs. Here, we sought to identify the transcriptomic signature of this phenotype and evaluate its clinical significance.Materials and methodsWe performed RNA sequencing analysis on tumor cells isolated from NSCLC (n=12) according to FHIT/pHER2 status and a functional analysis of differentially regulated genes. We also investigated the FHITlow/pHER2high signature in The Cancer Genome Atlas (TCGA) lung adenocarcinoma (LUAD) (n=489) and lung squamous cell carcinoma (LUSC) (n=493) cohorts and used the tumor immune dysfunction and exclusion (TIDE) model to test the ability of this signature to predict response to immune checkpoint inhibitors (ICI).ResultsWe showed that up-regulated genes in FHITlow/pHER2high tumors were associated with cell proliferation, metabolism and metastasis, whereas down-regulated genes were related to immune response. The FHITlow/pHER2high signature was associated with the higher size of tumors, lymph node involvement, and late TNM stages in LUAD and LUSC cohorts. It was identified as an independent predictor of overall survival (OS) in LUAD cohort. FHITlow/pHER2high tumors were also predictive of poor response to ICI in both LUAD and LUSC cohorts.ConclusionThese data suggest that ICI might not be a relevant option for NSCLC patients with FHITlow/pHER2high tumors and that anti-HER2 targeted therapy could be a good therapeutic alternative for this molecular subclass with poorer prognosis.
Published: 2022
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45. Emergency Medicine Clinician Experiences Addressing Uncertainty in First-Trimester Bleeding

Author: Garrison A Nord MD, Amanda MB Doty MS, Andrew J Monick BBA, Danielle M McCarthy MD, MS, Robin J Casten MEd, PhD, Amer Z Aldeen MD, Philip S Nawrocki MD, and Kristin L Rising MD, MSHP
Subjects: Medicine (General), R5-920
Abstract: The purpose of this work is to understand Emergency Department (ED) clinicians’ experiences in communicating uncertainty about first-trimester bleeding (FTB) and their need for training on this topic. This cross-sectional study surveyed a national sample of attending physicians and advanced practice providers (APPs). The survey included quantitative and qualitative questions about communicating with patients presenting with FTB. These questions assessed clinicians’ frequency encountering challenges, comfort, training, prior experience, and interest in training on the topic. Of 402 respondents, 54% reported that they encountered challenges at least sometimes when discussing FTB with patients where the pregnancy outcome is uncertain. While the majority (84%) were at least somewhat prepared for these conversations from their training, which commonly addressed the diagnostic approach to this scenario, 39% strongly or moderately agreed that they could benefit from training on the topic. Because the majority of ED clinicians identified at least sometimes encountering challenges communicating with pregnant patients about FTB, our study indicates a need exists for more training in this skill.
Published: 2022
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46. Is Innovation a Risky Business? A Comparative Analysis in High-Tech and Traditional Industries in Poland

Author: Tomasz L. Nawrocki and Izabela Jonek-Kowalska
Subjects: innovativeness, technology and its complexity, risk in innovative activity, the impact of innovativeness on risk, innovativeness in high-tech and traditional industries, Management. Industrial management, HD28-70, Business, HF5001-6182
Abstract: ABSTRACT: A high level of innovativeness and technology complexity is most often associated with a faster and more dynamic pace of economic development. In turn, it enables enterprises to achieve better financial results and strengthen their competitive advantage. Despite these potential benefits, in practice, innovation is also associated with the need to take up new challenges, which may be accompanied by a higher risk. The main goal of the research is a comparative analysis of the relationship between innovation and the risk of running a business in traditional and high-tech industries exemplified by the Polish economy. The authors assess the risk in 44 enterprises in the years 2010–2020 based on the proprietary evaluation model that uses the variation of financial parameters associated with innovativeness. The obtained results indicate a higher level of risk in the high-tech group with more complex and modern technologies, in particular in the pharmaceutical and computer games sectors. In the group of traditional enterprises, the risk in the analysed sectors is more diversified, and it is much higher in manufacturing enterprises than in services and trade. The empirical and quite extensive nature of the research allows for a practical assessment of the direction and strength of the relationship between innovation, risk and technology complexity.
Published: 2022
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47. Transcriptomic Characterization of Genes Regulating the Stemness in Porcine Atrial Cardiomyocytes during Primary In Vitro Culture

Author: Rut Bryl, Mariusz J. Nawrocki, Karol Jopek, Mariusz Kaczmarek, Dorota Bukowska, Paweł Antosik, Paul Mozdziak, Maciej Zabel, Piotr Dzięgiel, and Bartosz Kempisty
Subjects: cardiomyocytes, porcine cardiac muscle, long-term in vitro cell culture, stemness markers, transcriptomic analysis, Genetics, QH426-470
Abstract: Heart failure remains a major cause of death worldwide. There is a need to establish new management options as current treatment is frequently suboptimal. Clinical approaches based on autologous stem cell transplant is potentially a good alternative. The heart was long considered an organ unable to regenerate and renew. However, several reports imply that it may possess modest intrinsic regenerative potential. To allow for detailed characterization of cell cultures, whole transcriptome profiling was performed after 0, 7, 15, and 30 days of in vitro cell cultures (IVC) from the right atrial appendage and right atrial wall utilizing microarray technology. In total, 4239 differentially expressed genes (DEGs) with ratio > abs |2| and adjusted p-value ≤ 0.05 for the right atrial wall and 4662 DEGs for the right atrial appendage were identified. It was shown that a subset of DEGs, which have demonstrated some regulation of expression levels with the duration of the cell culture, were enriched in the following GO BP (Gene Ontology Biological Process) terms: “stem cell population maintenance” and “stem cell proliferation”. The results were validated by RT-qPCR. The establishment and detailed characterization of in vitro culture of myocardial cells may be important for future applications of these cells in heart regeneration processes.
Published: 2023
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48. The Assessment of the Rank of Torque Control during Incisor Retraction and Its Impact on the Resorption of Maxillary Central Incisor Roots According to Incisive Canal Anatomy—Systematic Review

Author: Anna Ewa Kuc, Jacek Kotuła, Jakub Nawrocki, Alicja Babczyńska, Joanna Lis, Beata Kawala, and Michał Sarul
Subjects: resorption, incisive canal, nasopalatine canal, retraction, Medicine
Abstract: Background: Root resorption is one of the complications of orthodontic treatment, and has a varied and unclear aetiology. Objective: To evaluate the relationship between upper incisor resorption and contact with the incisive canal and the risk of resorption during orthodontic treatment associated with upper incisor retraction and torque control. Search methods: According to PRISMA guidelines, the main research question was defined in PICO. Scientific databases MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched for linking keywords: Resorption of roots incisive canal, Resorption of roots nasopalatine canal, Incisive canal retraction and Nasopalatine canal retraction. Selection criteria: No time filters were applied due to the significantly limited number of studies. Publications in the English language were selected. Based on the information provided in the abstracts, articles were selected according to the following criteria: controlled clinical prospective trials and case reports. No randomised clinical trials (RCTs) or controlled clinical prospective trials (CCTs) were found. Articles unrelated to the topic of the planned study were excluded. The literature was reviewed, and the following journals were searched: American Journal of Orthodontics and Dentofacial Orthopedics, International Orthodontics, Journal of Clinical Orthodontics, Angle Orthodontist, Progress in Orthodontics, Orthodontics and Craniofacial Research, Journal of Orofacial Orthopedics, European Journal of Orthodontics and Korean Journal of Orthodontics. Data collection and analysis: The articles were subjected to risk of bias and quality assessment using the ROBINS-I tool. Results: Four articles with a total of 164 participants were selected. In all studies, differences in root length were observed after contact with the incisive canal, which was statistically significant. Conclusions and implications: The contact of incisor roots with the incisive canal increases the risk of resorption of these roots. IC anatomy should be considered in orthodontic diagnosis using 3D imaging. The risk of resorption complications can be reduced by appropriate planning of the movement and extent of the incisor roots (torque control) and the possible use of incisor brackets with built-in greater angulation. Registration CRD42022354125.
Published: 2023
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49. Efficiency of Polish Energy Companies in the Context of EU Climate Policy

Author: Tomasz L. Nawrocki and Izabela Jonek-Kowalska
Subjects: EU climate policy, CO2 emission allowances, the financial condition of Polish energy companies, the financial environmental restrictions, Technology
Abstract: The purpose of this article is to assess the impact of carbon allowances on the financial performance and strategic behavior of Polish energy companies listed on the Warsaw Stock Exchange, with a particular focus on the period when the price of these allowances increased. The eight largest Polish energy companies were surveyed, and the research period covered the period of 2010–2021. The research process used an analysis of financial condition and its determinants in the current and long-term perspective. In the current approach, the following were used: sales margin, operating margin, and cost and revenue structure. In the long-term approach, an assessment of the regularity of the capital structure and debt ratios was used. In both research perspectives, the results were confronted with the structure of power generation sources and the segmentation of the core business, including production, distribution, and trading. The results allow us to conclude that the increase in the price of emission allowances has adversely and most strongly affected companies focused on energy generation from high-carbon sources.
Published: 2023
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50. A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma

Author: Anastasios D. Giannou, Jöran Lücke, Dörte Kleinschmidt, Ahmad Mustafa Shiri, Babett Steglich, Mikolaj Nawrocki, Tao Zhang, Dimitra E. Zazara, Jan Kempski, Lilan Zhao, Olympia Giannou, Theodora Agalioti, Leonie Brockmann, Franziska Bertram, Morsal Sabihi, Marius Böttcher, Florian Ewald, Kornelius Schulze, Johann von Felden, Andres Machicote, Ioannis C. Maroulis, Petra C. Arck, Julia-Kristin Graß, Baris Mercanoglu, Matthias Reeh, Stefan Wolter, Michael Tachezy, Hannes Seese, Myrto Theodorakopoulou, Panagis M. Lykoudis, Asmus Heumann, Faik G. Uzunoglu, Tarik Ghadban, Oliver Mann, Jakob R. Izbicki, Jun Li, Anna Duprée, Nathaniel Melling, Nicola Gagliani, and Samuel Huber
Subjects: hepatocellular carcinoma, IL-22, IL-22BP, Th22, neutrophils, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads to hundred-thousands of deaths every year. Despite some groundbreaking therapeutical revelations during the last years, the overall prognosis remains poor. Although the immune system fights malignant transformations with a robust anti-tumor response, certain immune mediators have also been shown to promote cancer development. For example, interleukin (IL)-22 has been associated with HCC progression and worsened prognosis in multiple studies. However, the underlying mechanisms of the pathological role of IL-22-signaling as well as the role of its natural antagonist IL-22 binding protein (IL-22BP) in HCC remain elusive. Here, we corroborate the pathogenic role of IL-22 in HCC by taking advantage of two mouse models. Moreover, we observed a protective role of IL-22BP during liver carcinogenesis. While IL-22 was mainly produced by CD4+ T cells in HCC, IL-22BP was abundantly expressed by neutrophils during liver carcinogenesis. Hepatocytes could be identified as a major target of this pathological IL-22-signaling. Moreover, abrogation of IL-22 signaling in hepatocytes in IL22ra1flox/flox × AlbCre+ mice reduced STEAP4 expression-a known oncogene-in HCC in vivo. Likewise, STEAP4 expression correlated with IL22 levels in human HCC samples, but not in healthy liver specimens. In conclusion, these data encourage the development of therapeutical approaches that target the IL-22–IL-22BP axis in HCC.
Published: 2022
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