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This paper reports on investigations of elastic scattering reactions involving both, one proton-rich and one neutron-rich radioactive nuclei, 8B and 9Li respectively. These investigations highlighted the effects that the peculiar nuclear structure of these nuclei has on the reaction dynamics.

In our systematic research on reactions with weakly bound nuclei at suband nearbarrier energies, we have studied the system 8B+natZr at the sub-barrier energy of 26.5 MeV. Our measurements, performed at the TriSol radioactive beam facility of the University of Notre Dame, include angular distributions of both elastic scattering and breakup, for the determination of the total reaction and breakup cross sections as well as the direct-to-total reaction cross section ratio. Preliminary results of the breakup analysis will be presented, supported by Continuum Discretized Coupling Channel calculations.

We revisit the resonant break-up of 19C on protons at intermediate energies. In this reaction, it was found, for the first time in a halo nucleus to our knowledge, that the cross section was largely dominated by the excitation of the core. In this contribution, we study the robustness of this conclusion against the choice of different optical potentials for the core.

We study dineutron correlations in proton-target knockout reactions induced by Borromean two-neutron halo nuclei. Using a core + n + n three-body model for the projectile and a quasifree sudden reaction framework, we focus on the correlation angle as a function of the intrinsic neutron momentum. Our results indicate that the correlations are strong in a range of neutron momenta associated to the nuclear surface. We also discuss on the role of core excitations for such correlations.

17C structure is studied within a two-body model, a weakly bound neutron moving in a deformed potential generated by the core. A semi-microscopic method has been used to generate the deformed valencecore potential. The method consists of the convolution of a realistic nucleon-nucleon (NN) interaction with the core transition densities, which are obtained by antisymetrized molecular dynamics (AMD). The results highlight the important role of deformation for this nucleus and can be easily applied to reaction calculations.

The DTT tokamak, whose construction is starting in Frascati (Italy), will be equipped with an ECRH system of 16 MW for the first operation phase and with a total of 32 gyrotrons (170 GHz, ≥ 1 MW, 100 s), organized in 4 clusters of 8 units each in the final design stage. To transmit this large number of power beams from the gyrotron hall to the torus hall building a Quasi-Optical (QO) approach has been chosen by a multi-beam transmission line (MBTL) similar to the one installed at W7-X Stellarator. This compact solution, mainly composed of mirrors in “square arrangement” shared by 8 different beams, minimizes the mode conversion losses. The single-beam QOTL is used to connect each gyrotron MOU output to a beam-combiner mirror unit and, after the MBTL, from a beam-splitter mirror unit to the exvessel and launchers sections located in the equatorial and upper ports of 4 DTT sectors. A novelty introduced is that the mirrors of the TLs are embodied in a vacuum enclosure, using metal gaskets, to avoid atmospheric absorption losses and microwave leaks. The TL, designed for up to 1.5 MW per single power beam, will have a total optical path length between 84 m and 138 m from the gyrotrons to the launchers. The main straight section will travel along an elevated corridor ~10 m above the ground level. The development of the optical design reflects the constraints due to existing buildings and expected neutron flux during plasma operation. In addition, the power throughput of at least 90% should be achieved.

JT-60SA tokamak is equipped with an ECRF system since the beginning of its operational phase. Starting from two gyrotrons units during the Integrated Commissioning, applicable for core heating, assisted breakdown and assisted Wall Conditioning, the system capabilities will be progressively extended from the Initial Research phase for wider applications. The development of the full current plasma H mode scenario 2 (inductive, type I ELM, Ip=5.5 MA, BT=2.25 T, q95=3) is among the first scientific objectives of the research program. In preparation of this, predictive modelling of the current ramp-up in scaled versions of scenario 2 is being done, based on parameters previously published. In this scenario the ECRF power is injected from an early phase of the discharge. Such modelling provides the kinetic profiles giving the opportunity to estimate the expected amount of EC stray radiation during the ramp-up phase when the EC power absorption might be less than 100% and consequently the potential risk of damage of the in-vessel components is higher.

Abstract Background Despite their potential health and social benefits, adoption and use of improved cookstoves has been low throughout much of the world. Explanations for low adoption rates of these technologies include prices that are not affordable for the target populations, limited opportunities for households to learn about cookstoves through peers, and perceptions that these technologies are not appropriate for local cooking needs. The P3 project employs a novel experimental design to explore each of these factors and their interactive effects on cookstove demand, adoption, use and exposure outcomes. Methods The P3 study is being conducted in the Kassena-Nankana Districts of Northern Ghana. Leveraging an earlier improved cookstove study that was conducted in this area, the central design of the P3 biomass stove experiment involves offering stoves at randomly varying prices to peers and non-peers of households that had previously received stoves for free. Using household surveys, electronic stove use monitors, and low-cost, portable monitoring equipment, we measure how prices and peers’ experience affect perceptions of stove quality, the decision to purchase a stove, use of improved and traditional stoves over time, and personal exposure to air pollutants from the stoves. Discussion The challenges that public health and development communities have faced in spreading adoption of potentially welfare-enhancing technologies, like improved cookstoves, have highlighted the need for interdisciplinary, multisectoral approaches. The design of the P3 project draws on economic theory, public health practice, engineering, and environmental sciences, to more fully grasp the drivers and barriers to expanding access to and uptake of cleaner stoves. Our partnership between academic institutions, in the US and Ghana, and a local environmental non-governmental organization creates unique opportunities to disseminate and scale up lessons learned. Trial registration ClinicalTrials.gov NCT03617952 7/31/18 (Retrospectively Registered).

Background: Despite the relevance for occupational safety policies, the health effects of temperature on occupational injuries have been scarcely investigated. A nationwide epidemiological study was carried out to estimate the risk of injuries for workers exposed to extreme temperature and identify economic sectors and jobs most at risk. Materials and methods: The daily time series of work-related injuries in the industrial and services sector from the Italian national workers' compensation authority (INAIL) were collected for each of the 8090 Italian municipalities in the period 2006–2010. Daily air temperatures with a 1 × 1 km resolution derived from satellite land surface temperature data using mixed regression models were included. Distributed lag non-linear models (DLNM) were used to estimate the association between daily mean air temperature and injuries at municipal level. A meta-analysis was then carried out to retrieve national estimates. The relative risk (RR) and attributable cases of work-related injuries for an increase in mean temperature above the 75th percentile (heat) and for a decrease below the 25th percentile (cold) were estimated. Effect modification by gender, age, firm size, economic sector and job type were also assessed. Results: The study considered 2,277,432 occupational injuries occurred in Italy in the period 2006–2010. There were significant effects for both heat and cold temperatures. The overall relative risks (RR) of occupational injury for heat and cold were 1.17 (95% CI: 1.14–1.21) and 1.23 (95% CI: 1.17–1.30), respectively. The number of occupational injuries attributable to temperatures above and below the thresholds was estimated to be 5211 per year. A higher risk of injury on hot days was found among males and young (age 15–34) workers occupied in small-medium size firms, while the opposite was observed on cold days. Construction workers showed the highest risk of injuries on hot days while fishing, transport, electricity, gas and water distribution workers did it on cold days. Conclusions: Prevention of the occupational exposure to extreme temperatures is a concern for occupational health and safety policies, and will become a critical issue in future years considering climate change. Epidemiological studies may help identify vulnerable jobs, activities and workers in order to define prevention plans and training to reduce occupational exposure to extreme temperature and the risk of work-related injuries. Keywords: Climate change, Extreme outdoor air temperature, Occupational injuries, Heat impacts, Cold impacts, Case-crossover study

Francielle Topolski,1 Alexandre Moro,1,2 Gisele Maria Correr,3 Sasha Cristina Schimim1 1Department of Orthodontics, Positivo University, Curitiba, Paraná, Brazil; 2Department of Orthodontics, Federal University of Paraná, Curitiba, Paraná, Brazil; 3Department of Restorative Dentistry, Positivo University, Curitiba, Paraná, Brazil Abstract: Pain is an undesirable side effect of orthodontic tooth movement, which causes many patients to give up orthodontic treatment or avoid it altogether. The aim of this study was to investigate, through an analysis of the scientific literature, the best method for managing orthodontic pain. The methodological aspects involved careful definition of keywords and diligent search in databases of scientific articles published in the English language, without any restriction of publication date. We recovered 1281 articles. After the filtering and classification of these articles, 56 randomized clinical trials were selected. Of these, 19 evaluated the effects of different types of drugs for the control of orthodontic pain, 16 evaluated the effects of low-level laser therapy on orthodontic pain, and 21 evaluated other methods of pain control. Drugs reported as effective in orthodontic pain control included ibuprofen, paracetamol, naproxen sodium, aspirin, etoricoxib, meloxicam, piroxicam, and tenoxicam. Most studies report favorable outcomes in terms of alleviation of orthodontic pain with the use of low-level laser therapy. Nevertheless, we noticed that there is no consensus, both for the drug and for laser therapy, on the doses and clinical protocols most appropriate for orthodontic pain management. Alternative methods for orthodontic pain control can also broaden the clinician’s range of options in the search for better patient care. Keywords: tooth movement, pain control, drug therapy, laser therapy

We present a theoretical description of (p, pn) reactions induced by two-neutron halo nuclei at intermediate energies. For this purpose, we use a reaction framework that incorporates a full three-body model for the projectile, and we focus on the cases of 11Li and 14Be. Our results provide a direct link between the structure properties of these nuclei and different reaction observables, such as relative-energy spectra or momentum distributions. We discuss also on the link between dineutron correlations and opening-angle distributions.

The properties of nuclei with extreme neutron–to–proton ratios reveal the limitations of state-ofthe-art nuclear models and are key to understand nuclear forces. 7H, with six neutrons and a single proton, is the nuclear system with the most unbalanced neutron–to–proton ratio ever known, but its sheer existence and properties are still a challenge for experimental efforts and theoretical models. We report here the first measurement of the basic characteristics and structure of the ground state of 7H; they depict a system with a triton core surrounded by an extended four-neutron halo, built by neutron pairing, that decays through a unique four–neutron emission with a relatively long half-life. These properties are a prime example of new phenomena occurring in almost pure-neutron nuclear matter, beyond the binding limits of the nuclear landscape, that are yet to be described within our current models.

The evidence of Parametric Decay Instabilities (PDI) excited by the ECH power injected in O-Mode has been explored in FTU Tokamak, using the Collective Thomson Scattering (CTS) diagnostic. The experiments show evidences to support the hypothesis of low-threshold excitation of waves generated by PDI mechanisms, formerly proposed in the case of 2nd harmonic X-mode injection in TEXTOR and ASDEX-U. Theoretical analysis predicts low-threshold parametric decay also for O-mode pump-wave injection, which can be injected in FTU at frequencies close to the first Harmonic EC resonance. Experiments were made at different magnetic fields, injecting the 140 GHz probe and observing the emission from the second antenna of the EC launcher in poloidally symmetric and asymmetric configurations, in presence of MHD islands. The signal is detected by the CTS radiometers, with a fast digitizer allowing the spectral reconstruction at very fine time and frequency scales. Different types of emissions are studied in detail, comparing them with the magnetic island rotation frequency in different plasma conditions. In order to locate the plasma volume originating the emissions, a new antenna and receiving line has been installed.

Antecedentes: La llegada de los bisfosfonatos significó un adelanto en el tratamiento de la enfermedad ósea de Paget (EOP), pero se necesitan agentes más eficaces y de uso más cómodo para aumentar el cumplimiento terapéutico. El ácido zoledrónico, un bisfosfonato administrado en forma de una única perfusión intravenosa, podría satisfacer estas necesidades. Método: Hemos administrado una perfusión de 15 minutos de duración de 5 mg de ácido zoledrónico a pacientes con EOP. El criterio principal de valoración de la eficacia fue la tasa de respuesta terapéutica a los 6 y a los 12 meses, definida como una normalización de los niveles de fosfatasa alcalina (FA), de propéptido aminoterminal del procolágeno tipo 1 (P1NP), como marcadores de formación y de telopéptido carboxi-terminal del colágeno tipo 1 (CTx) como marcador de resorción. Hemos valorado asimismo la respuesta de la FA, CTx y P1NP a los 18 y 24 meses. Resultados: A los 6 meses y 12 meses, todos los pacientes que recibieron ácido zoledrónico presentaron una respuesta terapéutica con normalización de las cifras de FA, P1NP y CTx. La respuesta se mantuvo a los 18 y 24 meses aunque solo 1 paciente mostró elevación de la FA a los 24 meses coincidiendo con elevación de la gamma-glutamiltranspeptidasa hepática. Conclusiones: Una perfusión única de ácido zoledrónico produce una respuesta rápida, completa y sostenida en la EOP.

A demonstration fusion power plant (DEMO) producing electricity for the grid at the level of a few hundred megawatts is included in the European Roadmap [1]. The engineering design and R&D for the electron cyclotron (EC), ion cyclotron and neutral beam systems for the DEMO reactor is being performed by Work Package Heating and Current Drive (WPHCD) in the framework of EUROfusion Consortium activities. The EC target power to the plasma is about 50 MW, in which the required power for NTM control and burn control is included. EC launcher conceptual design studies are here presented, showing how the main design drivers of the system have been taken into account (physics requirements, reactor relevant operations, issues related to its integration as in-vessel components). Different options for the antenna are studied in a parameters space including a selection of frequencies, injection angles and launch points to get the best performances for the antenna configuration, using beam tracing calculations to evaluate plasma accessibility and deposited power. This conceptual design studies comes up with the identification of possible limits, constraints and critical issues, essential in the selection process of launcher setup solution.

This work reports on the scattering of 11Be on 197Au at energies around and below the Coulomb barrier. By experimentally identifying the elastic scattering, inelastic scattering and breakup channels, and comparing them with different calculations, valuable information on the 11Be structure and its B(E1) distribution to the continuum are obtained. On top of that, a deeper understanding of the scattering process at low energies is achieved for reactions of this kind, making these studies extendable to other loosely-bound systems like 17,19C

The upgrade of the EC-system of the TCV tokamak has entered in its realization phase and is part of a broader upgrade of TCV. The MW-class dual-frequency gyrotrons (84 or 126GHz/2s/1MW) are presently being manufactured by Thales Electron Devices with the first gyrotron foreseen to be delivered at SPC by the end of 2017. In parallel to the gyrotron development, for extending the level of operational flexibility of the TCV EC-system the integration of the dual-frequency gyrotrons adds a significant complexity in the evacuated 63.5mm-diameter HE11 transmission line system connected to the various TCV low-field side and top launchers. As discussed in [1], an important part of the present TCV-upgrade consists in inserting a modular closed divertor chamber. This will have an impact on the X3 top-launcher which will have to be reduced in size. For using the new compact launcher we are considering employing a Fast Directional Switch (FADIS), combining the two 1MW/126GHz/2s rf-beams into a single 2MW rf-beam.

Since 2014 under the umbrella of EUROfusion Consortium the Work Package Heating and Current Drive (WPHCD) is performing the engineering design and R&D for the electron cyclotron (EC), ion cyclotron and neutral beam systems of the future fusion power plant DEMO. This presentation covers the activities performed in the last two years on the EC system conceptual design, as part of the WPHCD, focusing on launchers, transmission lines, system reliability and architecture.

Nucleon removal (p, pn) and (p, 2p) reactions at intermediate energies have gained renewed attention in recent years as a tool to extract information from exotic nuclei. The information obtained from these experiments is expected to be sensitive to deeper portions of the wave function of the removed nucleon than knockout reactions with heavier targets. In this contribution, we present calculations for (p, 2p) and (p, pn) reactions performed within the so-called transfer to the continuum method (TR*). Results for stable and unstable nuclei are presented, and compared with experimental data, when available.

Fission and gamma decay probabilities of 237U and 239Np have been measured, for the first time simultaneously in dedicated experiments, via the surrogate reactions 238U(3He, 4He) and 238U(3He,d), respectively. While a good agreement between our data and neutron-induced data is found for fission probabilities, gamma decay probabilities are several times higher than the corresponding neutron-induced data for each studied nucleus. We study the role of the different spin distributions populated in the surrogate and neutron-induced reactions. The compound nucleus spin distribution populated in the surrogate reaction is extracted from the measured gamma-decay probabilities, and used as input parameter in the statistical model to predict fission probabilities to be compared to our data. A strong disagreement between our data and the prediction is obtained. Preliminary results from an additional dedicated experiment confirm the observed discrepancies, indicating the need of a better understanding of the formation and decay processes of the compound nucleus.

The current status of the reaction theory of nuclear collisions involving weakly-bound exotic nuclei is presented. The problem is addressed within the Continuum Discretized Coupled Channel (CDCC) framework, recalling its foundations and applications, as well as its connection with the Faddeev formalism. Recent developments and improvements of the method, such as core and target excitations and the extension to three-body projectiles, are presented. The use of the CDCC wave function in the calculation of inclusive breakup reactions is also introduced.

The experimental elastic scattering angular distributions of the collisions involving the weakly bound nuclei 6,7Li and the halo nucleus 6He on the same 64Zn target at several energies around the Coulomb barrier were measured at the Laboratori Nazionali del Sud (LNS, Italy), and the Cyclotron Research Center, Louvain La Neuve (Belgium), respectively. The experimental elastic scattering angular distributions of the 6,7Li + 64Zn systems have been analyzed within the continuumdiscretized coupled-channels method, while the 6He + 64Zn data have been compared with both continuum-discretized coupled-channels and coupled-reaction-channels calculations.

In 1980s Ichimura, Austern and Vincent [Phys.Rev.C 32, 431 (1985)] proposed a quantum mechanical theory to study the problem of inclusive breakup cross sections in the nuclear reactions. Using the DWBA version of this model, applications to deuteron and 6Li inclusive breakup reactions are presented and compared with some available data.

The four ITER Electron Cyclotron Upper Launchers (UL) are designed to control Magneto- Hydrodynamic instabilities with the deposition of Electron Cyclotron power. According to the present design, each launcher comprises two rows of four input waveguides, whose output beam is focused and driven towards the plasma by four sets of mirrors. In order to study the beam-launcher interaction throughout quasi-optical propagation, with particular attention to straylight behaviour, and to verify analytical calculations, a 3D model of the UL optical system has been implemented with the electromagnetic code GRASP® and the Physical Optics method. Detailed description of the components are introduced: pure hybrid mode HE11 from cylindrical waveguide as input beams, real shapes of the mirror contours, semi-analytical description of the ellipsoidal surfaces of focussing mirrors. A conceptual calculation scheme has been developed in order to take into account not only the direct contribution of the single source on its next scatterer but also the first order indirect effects: crosstalk from different lines of the same row and crosstalk from different rows have been evaluated after reflection on the first and third set of mirrors. The evaluations presented have been performed on the preliminary UL design, the last major milestone before finalization; however, the numerical model is suitable to be applied to future evolutions of the setup and/or other configurations.

Structure information of 11Li halo nucleus has been obtained from the inclusive break-up measurements of the 11Li+208Pb reactions at energies around the Coulomb barrier (Elab = 24.3 and 29.8 MeV). The effective break-up energy and the slope of B(E1) distribution close to the threshold have been extracted from the experimental data.

The electron cyclotron (EC) system of ITER for the initial configuration is designed to provide 20MW of RF power into the plasma during 3600s and a duty cycle of up to 25% for heating and (co and counter) non-inductive current drive, also used to control the MHD plasma instabilities. The EC system is being procured by 5 domestic agencies plus the ITER Organization (IO). F4E has the largest fraction of the EC procurements, which includes 8 high voltage power supplies (HVPS), 6 gyrotrons, the ex-vessel waveguides (includes isolation valves and diamond windows) for all launchers, 4 upper launchers and the main control system. F4E is working with IO to improve the overall design of the EC system by integrating consolidated technological advances, simplifying the interfaces, and doing global engineering analysis and assessments of EC heating and current drive physics and technology capabilities. Examples are the optimization of the HVPS and gyrotron requirements and performance relative to power modulation for MHD control, common qualification programs for diamond window procurements, assessment of the EC grounding system, and the optimization of the launcher steering angles for improved EC access. Here we provide an update on the status of Europe’s contribution to the ITER EC system, and a summary of the global activities underway by F4E in collaboration with IO for the optimization of the subsystems.

The 24 MW ITER Electron Cyclotron (EC) Heating and Current Drive (H&CD) system, operating at 170 GHz, consists of one Equatorial (EL) and four Upper Launchers (UL). The main task of the UL will be the control of Magneto-Hydrodynamic (MHD) activity such as Neoclassical Tearing Modes (NTMs) at the q=3/2 and q=2 surfaces, but it will also be needed for current profile tailoring in advanced scenarios and to assist plasma break-down and L- to H-mode transition. Moreover, it is required to be e.ective both when ITER will operate at nominal and reduced magnetic field magnitude. Here the performance of the UL is assessed through the study of the full temporal evolution of di.erent scenarios, including the reference ITER 15MA H-mode plasma, a half-field case at 2.65T, and a steady state scenario. The ECCD efficiency has been evaluated for a wide range of injection angles, deriving the optimal angles and the power required for NTMs stabilization, as well as the steering range necessary to reach the rational surfaces during all the phases of the discharge. The steering sensitivity to shifts of the target or aiming errors has been estimated too. The result is an assessment of the UL design requirements to achieve the desired functionalities, which, together with the engineering limits, will be used to drive the optimization and finalization of the UL design.

Experimental cross sections for the 6He+120Sn are analysed. Elastic scattering angular distributions and alpha particle production cross sections have been measured and are compared with the total reaction cross sections.

The exotic nucleus 8He is investigated by means of the measurement of the angular distributions of the elastic channel and the 6He and 4He fragment yields produced in the collision with a 208Pb target at two energies around the Coulomb barrier, 16 and 22 MeV. The experiment was performed at the GANIL-SPIRAL facility, with the aim of extracting information about the structure of 8He and the relevant reaction mechanisms. In this contribution, details of the experimental setup and preliminary data on elastic cross sections are reported.

We present the results of experiments using a 6He beam on a 9Be target at energies 7 − 9 times the Coulomb barrier. Angular distributions of the elastic, inelastic scattering (target breakup) and the a-particle production in the 6He+9Be collision have been analysed. Total reaction cross sections were obtained from the elastic scatteringanalyses and a considerable enhancement has been observed by comparing to stable systems.

The elastic and break-up angular distributions of the 10,11Be+64Zn reactions measured at Ec.m.≈1.4 VC have been analysed within the CCDC and O.M. frameworks. The suppression of the Coulomb-nuclear interference, observed in the 11Be scattering case with respect to the 10Be, has been interpreted as due to a long range absorption owing to the coupling with the break-up (Coulomb and nuclear) channels. The presence of 10Be events on the 11Be experiment data have been explained as due mainly to break-up processes.

We report here on experiments performed at TRIUMF to study the scattering of the light halo nuclei 11Li on lead at energies below and around the Coulomb barrier. The the elastic and break-up differential cross section are interpreted in the framework of Continuum-Discretized Coupled-Channel calculations. The departure from Rutherford scattering at energies below the barrier is well beyond the behavior of normal nuclei.

We analyse the resonant break-up of halo nuclei including possible excitations of the core both in the structure of the halo nucleus and in the reaction dynamics. The structure of the halo nucleus is treated in the weak-coupling limit, assuming a particle+core model with core excitations. The bound and resonant states of this system are calculated as an expansion in a pseudo-state basis, for which we use a recent generalization of the Transformed Harmonic Oscillator basis. This basis is used within a distorted wave Born approximation reaction framework which includes possible excitations and deexcitations of the core during the collision. We apply this scheme to describe the resonant break-up of 11Be on 12C at 67 MeV/u. Comparing with the available experimental data from RIKEN [N. Fukuda et al., PRC 70, 054606 (2004)] we discuss the possibility of extracting spectroscopic information of 11Be resonances from the analysis of the break-up angular distributions.

An upgraded version of a quasi-optical diplexer combiner, based on a resonating system coupling two transmission lines using three Dielectric Beam Splitters, has been realized and tested. This device is principally thought to combine power coming from different transmission lines into a single output or to switch the injected power between different outputs, but it could also be used as mode filter or in line viewing system for Electron Cyclotron Emission (ECE) or Collective Thomson Scattering (CTS) diagnostics. The design was implemented in order to link two transmission lines of the ECRH system on FTU, for power combination of two beams into a single line of the new ECRH launcher recently installed. This device is based on Dielectric Beam Splitters (DBS); it has been tested at low power in order to confirm the splitting ratio foreseen from simulation and its efficiency has been evaluated measuring the beam exiting the system. The design and the characterization of the diplexer combiner are reported in this paper.

The Real-Time system for the control of the magnetohydrodynamics instabilities in FTU tokamak is presented. It is based on both a-priori information derived from statistical treatment of a database and Real-Time elaboration of live diagnostics data. The analysis codes are executed in different time threads based on multi-processors machines. The actuator is the 2×0.4MW 140 GHz ECRH system equipped with the new fast quasi-optical steerable launcher.

The Electron Cyclotron (EC) fast launcher for real time control experiments has been installed on FTU and characterized to be fully integrated in a real-time MHD control module under development. The launcher scheme is based on a two module system, symmetric with respect to the equatorial plane of FTU, with a front steering concept and the launched beams are real-time controllable both in poloidal and toroidal directions. Specific design parameters, defined by the FTU MHD dynamics (typically island size and q profile changes), are the beam dimensions with zooming capabilities, the steering range and mirror speed with the most demanding requirement on poloidal speed of the Steering Mirror (SM) Δθ = 1° in 10 ms. A set of tests has been done to verify the system performance. High power tests of the launcher have been done on a 500 kA, 0.5·1020m−3 and 5.3 T plasma with 2·300 kW of EC power delivered to the plasma. The steering mechanism was tested under the automatic control system and showed a dynamic response in line with the requirements. Results of these tests will be presented in the paper.

In order to study the dynamics of 11Li and 9Li beams in a strong electric field at energies around the Coulomb barrier, we measured at the ISACII-TRIUMF Facility the angular distribution of elastic and inelastic scattering of 11Li+208Pb at 24.2 and 29.7 MeV and 9Li+208Pb at 24, 29.5 and 33 MeV laboratory energies. We present here the first determination of the angular distribution of the cross section of 9Li+208Pb. The results are compared with theoretical calculations using the double-folding São Paulo Potential (SPP) for the real part and a for the imaginary part a Woods-Saxon potential. A good overall agreement is obtained.

We present some recent applications of the Continuum-Discretized Coupled-Channels (CDCC) and Coupled-Reaction-Channels (CRC) methods to the study of reactions induced by weakly-bound nuclei on stable targets. The methods are applied to the scattering of the Borromean nucleus 6He at energies around the Coulomb barrier. Elastic scattering data are very well described by four-body CDCC calculations (based on a three-body description of the 6He nucleus) but also by simpler three-body CDCC calculations, using a suitable two-body model for 6He. By contrast, inclusive α data are better described using the CRC approach, which treats the breakup within the transfer to the continuum picture and, unlike the CDCC method, allows the inclusion of transfer to bound states of the target. We explore also the possibility of calculating the fusion cross sections using the CRC framework.

Abstract Background We sought to investigate the relationships among the plasma levels of carotenoids, tocopherols, endogenous antioxidants, oxidative damage and lipid profiles and their possible effects on the cardiovascular risk associated with hemodialysis (HD) patients. Methods The study groups were divided into HD and healthy subjects. Plasma carotenoid, tocopherol and malondialdehyde (MDA) levels, as well as erythrocyte reduced glutathione (GSH), were measured by HPLC. Blood antioxidant enzymes, kidney function biomarkers and the lipid profiles were analyzed by spectrophotometric methods. Results Plasma lycopene levels and blood glutathione peroxidase (GPx) activity were significantly decreased in HD patients compared with healthy subjects. Total cholesterol, low-density lipoprotein cholesterol (LDL-c), creatinine, urea, MDA, GSH, superoxide dismutase (SOD) and catalase (CAT) were significantly increased in HD (p < 0.05). Lycopene levels were correlated with MDA (r = -0.50; p < 0.01), LDL-c (r = -0.38; p = 0.01) levels, the LDL-c/HDL-c index (r = -0.33; p = 0.03) and GPx activity (r = 0.30; p = 0.03). Regression models showed that lycopene levels were correlated with LDL-c (β estimated = -31.59; p = 0.04), while gender was correlated with the TC/HDL-c index and triglycerides. Age did not present a correlation with the parameters evaluated. GPx activity was negatively correlated with MDA levels and with the LDL-c/HDL-c and CT/HDL-c indexes. Conclusions Lycopene may represent an additional factor that contributes to reduced lipid peroxidation and atherogenesis in hemodialysis patients.

Abstract A rare case of aneurysmal bone cyst (ABC) located in the mandibular condyle in a 10-year-old boy is presented. The patient came to our attention for a sudden swelling in the right temporomandibular region, the mouth opening was not reduced. A rapid growing mass, depicting soft tissue invasion, in the right condyle of the mandible was found. Clinically and radiographically it resembled to a malignant lesion. The surgical excision of the mandibular condyle allowed a complete removal of the lesion. The histological examination revealed a pseudocystic expanding osteolytic lesion containing blood-filled space separated by connective tissue and many osteoclastic giant cells, which was a conventional vascular ABC. The ABC is an infrequent bone lesion which can only be found very rarely at the craniofacial skeleton. There have been described about 160 cases of ABC originated in the molar region or in upper maxilla and even more rare is the location of this cyst in the mandibular condyle. Only 6 cases were reported in the literature to date. A complete surgical resection of this osteolytic lesion is the treatment of choice considering its high recurrence rate. The condyle was not replaced with any graft. Therefore a functional device was used after surgery to overcome the lack of the condyle and to stimulate the growth of the ramus.

Abstract Introduction Clear cell neoplasms of the jaw are very infrequent and a review of the literature reports only isolated cases of metastatic renal clear cell carcinoma of the jaw. Case presentation A 68-year-old man presented with an osteolytic lesion of the left hemimandible. The first diagnostic hypothesis was a third molar follicular cyst. Surgical treatment consisted of enucleating the lesion preserving the alveolar nerve and extracting of the retained tooth. Unexpectedly, the lesion presented as a solid. Conclusion The authors report a case of a clear cell neoplasm involving the jaw in which histopathological exam presented an indeterminate histology. The histological characteristics of this tumor make it unique in the international literature.

Abstract Background We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle. Methods Sections from 17 benign lesions and 55 carcinomas were immunostained with anti DMBT1 antibody (DMBTh12) and sections from 36 samples, were double-stained also with anti MCM5, one of the 6 pre-replicative complex proteins with cell proliferation-licensing functions. DMBT1 gene expression at mRNA level was assessed by RT-PCR in frozen tissues samples from 39 patients. Results Normal glands and hyperplastic epithelium in benign lesions displayed a luminal polarized DMBTh12 immunoreactivity. Normal and hyperplastic epithelium adjacent to carcinomas showed a loss of polarization, with immunostaining present in basal and perinuclear cytoplasmic compartments. DMBT1 protein expression was down-regulated in the cancerous lesions compared to the normal and/or hyperplastic epithelium adjacent to carcinomas (3/55 positive carcinomas versus 33/42 positive normal/hyperplastic epithelia; p = 0.0001). In 72% of cases RT-PCR confirmed immunohistochemical results. Most of normal and hyperplastic mammary cells positive with DMBTh12 were also MCM5-positive. Conclusions The redistribution and up-regulation of DMBT1 in normal and hyperplastic tissues flanking malignant tumours and its down-regulation in carcinomas suggests a potential role in breast cancer. Moreover, the concomitant expression of DMTB1 and MCM5 suggests its possible association with the cell-cycle regulation.

Abstract Glioblastoma is an aggressive brain cancer with a poor prognosis. The O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to develop an artificial intelligence (AI) framework for predicting MGMT methylation. Diagnostic magnetic resonance (MR) images in public repositories were used for training. The algorithm created was validated in data from a single institution. All images were segmented according to widely used guidelines for radiotherapy planning and combined with clinical evaluations from neuroradiology experts. Radiomic features and clinical impressions were extracted, tabulated, and used for modeling. Feature selection methods were used to identify relevant phenotypes. A total of 100 patients were used for training and 46 for validation. A total of 343 features were extracted. Eight feature selection methods produced seven independent predictive frameworks. The top-performing ML model was a model post-Least Absolute Shrinkage and Selection Operator (LASSO) feature selection reaching accuracy (ACC) of 0.82, an area under the curve (AUC) of 0.81, a recall of 0.75, and a precision of 0.75. This study demonstrates that integrating clinical and radiotherapy-derived AI-driven phenotypes can predict MGMT methylation. The framework addresses constraints that limit molecular diagnosis access.

Abstract This study evaluates the safety and potential benefits of PBM on pancreatic beta cells and islets. PBM was applied to insulin-secreting cell lines (MIN6) and rat pancreatic islets using a 670 nm light source, continuous output, with a power density of 2.8 mW/cm², from 5 s to several 24 h. Measure of cell viability, insulin secretion, mitochondrial function, ATP content, and cellular respiration were assessed. Additionally, a diabetic rat model is used for islet transplantation (pre-conditioning with PBM or not) experiments. Short and long-term PBM exposure did not affect beta cell islets viability, insulin secretion nor ATP content. While short-term PBM (2 h) increases superoxide ion content, this was not observed for long exposure (24 h). Mitochondrial respirations were slightly decreased after PBM. In the islet transplantation model, both pre-illuminated and non-illuminated islets improved metabolic control in diabetic rats with a safety profile regarding the post-transplantation period. In summary, for the first time, long-term PBM exhibited safety in terms of cell viability, insulin secretion, energetic profiles in vitro, and post-transplantation period in vivo. Further investigation is warranted to explore PBM’s protective effects under conditions of stress, aiding in the development of innovative approaches for cellular therapy.

Dry mass is an important parameter to optimise grassland management. Traditionally, dry mass values are estimated manually by cutting, drying, and weighing vegetation samples. In large areas of cultivation, this becomes a time-consuming and costly activity. In recent years, many researchers have studied different sensors embedded in Unmanned Aerial Vehicles (UAV) to collect spatial data and estimate biomass using machine learning algorithms for forest and agricultural applications. However, there needs to be more research dealing with estimating production indices for pasture, especially in Brazil, as stated. This study evaluates the feasibility of using the GoPro wide-angle RGB camera on UAVs (Unmanned Aerial Vehicles) to estimate the dry mass of pastures. Different data analysis methods were compared, including the combination of vegetation indices (VIs) values and three-dimensional metrics (3D) extracted from the Canopy Height Model (CHM): all metrics (ALL), three VIs plus four 3D metrics (VI3 + CHM4) and only 3D metrics. Random Forest (RF) machine learning algorithm was used to estimate dry mass. The best results were obtained when merging all the variables from the two flight campaigns, with a coefficient of determination (R2) of 0.80 for the model and a Pearson Correlation Coefficient (PCC) of 0.85 for validation, with a Root Mean Square Error (RMSE%) of 20.5%. In summary, using RGB sensors embedded in UAVs is a promising technique for estimating farm grazing parameters.

Management decisions about store atmosphere, such as temperature, or light intensity in retail establishments can be made based on solutions from machine learning methods. These conditions determine whether the customer will stay in the store longer and whether his shopping cart will reach the desired high value. Previous literature research associates certain atmospheric factors with customers' propensity to make purchasing decisions and allows us to identify what influences the customer during shopping and to what extent. The article aims to reveal the feasibility of using machine learning methods to make management decisions based on store atmosphere parameters. When deciding on the conditions in a retail establishment, applicable health and safety regulations should also be considered. This was used to set limits on the input parameters for the model. The authors identified 3 atmospheric factors and, based on them, proposed two types of models: regression and classification models, predicting how long customers stay in an establishment and can classify it into categories: short, medium and long. These models can then be used to create a model that optimizes the parameters in the facility to achieve a minimum given time a customer stays in the facility.