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Background: Acrylic resin bases attract stains and odor producing organic and inorganic deposits. The use of chemical denture cleanser soaks is the most popular method of denture cleansing. Aim: To compare the efficacy of 2 different denture cleansers in removing tea, coffee, turmeric and paan stains from heat cured clear acrylic resins. Materials and Methods: Two hundred heat cured clear acrylic samples were prepared. The samples were divided into four groups and stored in tea, coffee, turmeric and paan at 37°C for 10 days. Stained samples were subjected to immersion in the commercially available denture cleansers sodium perborate (Clinsodent), sodium hypochlorite (VI-Clean) and distilled water (control). Optical density (OD) values were measured before and after 20 minutes and 8 hours of immersion in the cleansers. The data were analyzed statistically using Fischer′s test (one way ANOVA) and multiple comparisons were done by Bonferroni test. Results: Both Clinsodent and VI-clean were found to be least effective in removal of coffee stains and best for removing turmeric stains. Conclusion: It is necessary for the dental professional to ensure that the denture wearing public knows how to select the appropriate denture cleanser so as to improve denture home care protocol.