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Liquefaction can cause significant damage to the built environment; therefore, assessing the liquefaction hazard in a seismically active region is essential to minimize the risk. This study attempted to evaluate the liquefaction potential of the south-central coastal areas of Bangladesh by calculating the liquefaction potential index (LPI) considering a scenario earthquake of Mw ​= ​7.5 having a peak ground acceleration of 0.15g. For calculating LPI, both standard penetration test blow count (SPT-N) and shear wave velocity (Vs) data have been used in this study. The results show that the study area's LPI values vary from 0 to 37. A liquefaction hazard map is prepared for the area using the calculated LPI values from Vs data shows about 8% of the study area is very highly susceptible to liquefaction hazard, whereas 62% of the area falls under high hazard-prone area while about 28% and 2% area of the study have respectively low (0

Changes in river bank location have wide consequences on floodplain communities and the sustainability of floodplain ecosystems. Although river dynamics are monitored globally and locally, understanding the impact of riverine dynamics on land use change remains a challenge. Bangladesh, part of the Bengal Delta, is mostly made up of alluvial deposits and is crisscrossed by so many rivers. Jamuna is one of the prominent rivers in this region. This study presents a consistent evaluation of the dynamics of the Jamuna river and ensuing changes in land use over 48 years (1972–2020) depending on satellite observations and geospatial analysis. Changes in the presence of water were used to estimate the advance/retreat of the banks and loss/gain of land along 257 perpendicular transects along the common pattern of the centerlines of the river. We found that the overall loss of agricultural land was about 535.01 km2, sevenfold of the gained agricultural land. Other land use losses were bare lands 136.73 km2, waterbodies 80.37 km2, settlement 67.28 km2 and vegetation 132.79 km2 against 48.47 km2, 3.52 km2, 23.76 km2 and 6.14 km2 land use gains respectively. Agricultural land loss impacts the livelihood of the floodplain dwellers and settlement loss causes internal migration. This pattern of land use change driven by the river dynamics has created newer environmental challenges and additionally, climate change may intricate the situation in the future. The findings of this study throw insight into the fact and may aid in sustainable river training measures and floodplain management.

Aim – to find regular patterns in the morphometric characteristics for the bodies of the cervical vertebrae when performing measurements in the axial (transverse) plane in men and women with different severity of degenerative-dystrophic changes of the cervical spine. Material and methods. The material of the study was the tomograms of 75 men and 128 women aged 18 to 84 years, obtained on magnetic resonance tomographs with a magnetic field strength of 1 Tl and 1.5 Tl. The data was divided into several groups according to the patients' sex and severity of degenerative-dystrophic changes of the cervical spine. The length and width of the vertebral bodies in the axial plane were measured with the subsequent calculation of their ratio. Results. Significant differences were found between the 1st and 2nd groups for the width of C7-C4 in women, as well as for the length of C3 and width of C3, C2 in men. Significant difference in the ratio of the sizes of vertebral bodies was registered in the 1st and 2nd groups of women at the level of C7. When comparing the data of all observation groups among men, significant differences were noted in the 2nd and 3rd groups for C7, C6, C3. With progression of degenerative-dystrophic changes, the differences in length were significant for C7-C4, C2 vertebrae in the 1st group, for C7-C5, C2 – in the 2nd and C7, C6, C4-C2 in the 3rd group. In the group of men with pronounced changes in the cervical spine region, in most cases there was an increase in coefficients (with significant differences in data for the 2nd and 3rd groups). Conclusion. Among men, significant differences were observed between the 2nd and 3rd groups for C7, C6, C3. For the C2 vertebra, significant differences were noted, taking into account sex, for length in the 1st and 3rd groups, width – in the 1st and 2nd groups, when assessing the mutual ratio of the sizes of the vertebral bodies – in the 2nd and 3rd groups.

Abstract The rise in temperatures and changes in other meteorological variables have exposed millions of people to health risks in Bangladesh, a densely populated, hot, and humid country. To better assess the threats climate change poses to human health, the wet bulb globe temperature (WBGT) is an important indicator of human heat stress. This study utilized high-resolution reanalysis data from the fifth-generation European Centre for Medium-Range Weather Forecasts (ECMWF ERA5) to analyze the spatiotemporal changes in outdoor WBGT across Bangladesh from 1979 to 2021, employing Liljegren's model. The study revealed an increase in the annual average WBGT by 0.08–0.5 °C per decade throughout the country, with a more pronounced rise in the southeast and northeast regions. Additionally, the number of days with WBGT levels associated with high and extreme risks of heat-related illnesses has shown an upward trend. Specifically, during the monsoon period (June to September), there has been an increase of 2–4 days per decade, and during the pre-monsoon period (March to May), an increase of 1–3 days per decade from 1979 to 2021. Furthermore, the results indicated that the escalation in WBGT has led to a five-fold increase in affected areas and a three-fold increase in days of high and extreme heat stress during the monsoon season in recent years compared to the earlier period. Trend and relative importance analyses of various meteorological variables demonstrated that air temperature is the primary driver behind Bangladesh's rising WBGT and related health risks, followed by specific humidity, wind speed, and solar radiation.

Diabetes mellitus (Type 2) is a major world health problem spreading speedily throughout the world. It is a chronic illness that necessitates long-term therapy and care. Therefore, the therapy to treat and manage the disease should not only be safe and effective but should also be affordable. In countries like India, the cost of the therapy must be economical so that it can be easily afforded by common people. This review article mainly focuses on the novel drug dapagliflozin, a SGLT-2 inhibitor, and discusses its various aspects. It acts independently of the insulin pathway by inhibiting the reuptake of glucose in the renal tubules, allowing glycosuria to take place. This helps decrease blood glucose levels. Dapagliflozin is effective as both, monotherapy and combination therapy depending on the severity of the case as indicated by multiple studies. Since, only one daily dose is sufficient, this may be a more reasonable option for many low-income group patients. Many new medications are in development but dapagliflozin could be the major turning factor in managing T2DM along with metformin, sulfonylurea, insulin, pioglitazone, and DPP-4 inhibitors as mono or combination therapy.

Principal component analysis (PCA) can reduce the subjectivity of Water quality index (WQI) models by reducing parametric dimension and has gained immense attention in exploring water quality among researchers. Therefore, this study focuses on developing a novel WQI model for 4 Dhaka-based rivers namely Buriganga, Turag, Balu, and Shitalakhya following PCA as a method for selecting and weighting water quality parameters. The dataset includes 12 water quality parameters from 19 sites of these rivers sourced from the Department of Environment (DoE), Bangladesh. Correlation analysis followed by PCA, was conducted to decrease the parameter count from 12 to 7. The Measure of Sampling Adequacy (MSA) was found to be 0.853 in the Kaiser-Meyer-Olkin (KMO) test and Bartlett’s test of sphericity was significant at an alpha level of 0.05 indicating the dataset was suitable for factor analysis. Sub-indexing was introduced with the quality rating curves provided by the National Sanitation Foundation (NSF)-WQI model and modified rating curves for specific parameters with statistical dispersion. The calculated WQI values for 209 samples ranged from 36 (Bad) to 82 (Good) on a scale of 100. More than 70 % of the samples were in the medium or bad, and the rest were in the good category. The trend in WQI across the rivers indicated higher values during the wet season, attributed to the dilation from local rainfall. By incorporating a well-distributed dataset spanning several years, this statistical approach effectively minimizes the subjectivity and bias in developing WQI models for rivers in Dhaka, contributing to more robust future model development. Moreover, this study introduces a modern approach for assessing the river water quality of Dhaka city that can be incorporated into the river pollution control strategies.

ABSTRACTThis scoping review summarises the findings of research conducted on cancer screening in Bangladesh, including the prevalence, awareness, barriers, and evaluation of screening programmes, by performing a comprehensive search of electronic databases and gray literature. 25 studies that met inclusion criteria were included in the final analysis. Most of the studies were about screening for cervical cancer, were quantitative, were cross-sectional, and were conducted in hospital settings. The main challenges to screening uptake were shyness, fear, a lack of knowledge, and an inadequate understanding of the concept of screening. Visual inspection with acetic acid (VIA) was found to be a simple and cost-efficient way to detect early-stage cervical cancer. However, breast self-examination (BSE) was reported to be insufficient. Education was found to have a positive impact on cancer screening knowledge and practice, but more needs to be done to improve screening rates, such as the utilisation of media, particularly in rural areas. The results of this scoping review highlight Bangladesh's low cancer screening prevalence and uptake and suggest that targeted awareness campaigns and enhanced access to screening services are required to increase cancer screening uptake and reduce the cancer burden in Bangladesh.

AbstractDeltas like the Ganges-Brahmaputra Delta (GBD) experience significant land subsidence due to overlaying load, consolidation, sediment compaction, regional tectonics, and human activity. The southwestern region of Bangladesh, marked by its low-lying floodplain with compressible sediments, experiences significant land subsidence. However, accurate assessments for these areas are very scarce, often focusing on the point-based measurements. This study employed Interferometric Synthetic Aperture Radar analysis, spanning from 2014 to 2022, to effectively measure land subsidence, and visualize it spatially. In the study area, subsidence rates were found to be ranging from 3 to 20 mm/year, with most areas experiencing 3-10 mm/year. While some areas show higher rates of 10-13 mm/year, very few exceeded 14 mm/year. The average subsidence rate was 5.98 mm/year, demonstrating significant spatial variability, with higher rates in Gopalganj, Patuakhali, Bhola, Barishal, and other areas. The findings were validated based on existing Global navigation satellite system (GNSS) data points, affirming their reliability. Despite minor discrepancies with other measurements at specific points, the overall results align well with existing data. This comprehensive analysis provides a detailed assessment of land subsidence in the southwestern region of Bangladesh, highlighting significant spatial variability and offering valuable insights for future coastal development and risk mitigation strategies.

This manuscript presents a novel state-of-the-art cyber-physical water testbed, namely the AI and Cyber for Water and Agriculture testbed (ACWA). ACWA is motivated by the aim to advance water resources' management using AI and cybersecurity experimentation. The main objective of ACWA is to address pressing challenges in the water and agricultural domains by utilising cutting-edge AI and data-driven technologies. These challenges include cyberbiosecurity, resources' management, access to water, sustainability, and data-driven decision-making, among others. To address such issues, ACWA is built consisting of topologies, sensors, computational clusters, pumps, tanks, smart water devices, as well as databases and AI models that control the system. Moreover, we present ACWA simulator, which is a software-based water digital twin. The simulator is based on fluid and constituent transport principles that produce a theoretical time series of a water distribution system. It creates a benchmark for comparing the theoretical approach with real-life outcomes via the physical ACWA testbed. ACWA data are available to AI and water sector researchers and are hosted in an online public repository. In this paper, the system is introduced and compared with existing water testbeds; additionally, use cases are described along with novel outcomes, such as datasets, software, and AI models. HIGHLIGHTS ACWA is a novel cyber-physical testbed for testing, validating, and experimenting with intelligent water systems and AI.; The testbed consists of multiple sensors, computational nodes, pumps, pipes, valves, tanks, and other computational components.; Open water domain datasets with multiple variables are publicly available via ACWA, including ones that enable the testing of Cyberbiosecurity and AI deployments in water systems.; ACWA is the first data generator of its kind (hardware and software) in the water domain.;

Background Flexor tendon injury zone V is a multicomponent soft tissue injury involving tendons, nerves, and vessels. Outcome assessment of repair thus requires evaluation of the hand as a whole rather than solely evaluating tendon function. The purpose of this Preferred Reporting Items for Systematic Reviews and Meta-Analyses -compliant systematic review was to identify and assess the components of outcome measures used in flexor zone V.

Background: A novel nanosomal paclitaxel lipid suspension (NPLS), free from Cremophor EL (CrEL) and ethanol, was developed to address the solvent-related toxicities associated with conventional paclitaxel formulation. Objective: To evaluate the efficacy and safety of NPLS versus CrEL-based paclitaxel (conventional paclitaxel) in patients with metastatic breast cancer (MBC). Design: A prospective, open-label, randomized, multiple-dose, parallel, phase II/III study. Methods: Adult (18–65 years) female patients with MBC who had previously failed at least one line of chemotherapy were randomized (2:2:1) to NPLS 175 mg/m 2 every 3 weeks (Q3W, n = 48, arm A), NPLS 80 mg/m 2 every week (QW, n = 45, arm B) without premedication or conventional paclitaxel (Taxol ® , manufactured by Bristol-Myers Squibb, Princeton, NJ, USA) 175 mg/m 2 Q3W ( n = 27, arm C) with premedication. In the extension study, an additional 54 patients were randomized (2:1) to arm A ( n = 37) or arm C ( n = 17). Results: Pooled data from the primary study and its extension phase included 174 patients. The primary endpoint was the overall response rate (ORR). As per intent-to-treat analysis, ORR was significantly better in the NPLS QW arm as compared to conventional paclitaxel [44.4% (20/45) versus 22.7% (10/44), ( p = 0.04)]. An improvement in ORR with NPLS Q3W versus conventional paclitaxel arm [29.4% (25/85) versus 22.7% (10/44)] ( p = 0.53) was observed. Disease control rates observed were improved with NPLS Q3W versus conventional paclitaxel Q3W (77.7% versus 72.7%, p = 0.66) and with NPLS QW versus conventional paclitaxel Q3W (84.4% versus 72.7%, p = 0.20), although not significant. A lower incidence of grade III/IV peripheral sensory neuropathy, vomiting, and dyspnea was reported with NPLS Q3W versus conventional paclitaxel Q3W arms. Conclusion: NPLS demonstrated an improved tumor response rate and a favorable safety profile versus conventional paclitaxel. NPLS 80 mg/m 2 QW demonstrated a significantly better response versus conventional paclitaxel 175 mg/m 2 Q3W. Trial registration: Clinical Trial Registry-India (CTRI), CTRI/2010/091/001344 Registered on: 18 October 2010 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjEzNQ==&Enc=&userName=CTRI/2010/091/001344), CTRI/2015/07/006062 Registered on: 31 July 2015 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTE2Mjc=&Enc=&userName=CTRI/2015/07/006062)

The salinisation of freshwater resources is a priority concern in Asian mega-deltas including the Bengal Basin of Bangladesh where the livelihoods, ecosystem services and health of coastal populations are increasingly under threat. Understanding trends and variations in surface water salinity is required to inform sustainable use of freshwater supplies in the face of hydrological regimes intensified by global environmental change. We interrogate 86 time series of fortnightly records of in situ surface water salinity between 1990 and 2019. Statistical and geospatial techniques were employed to characterise spatiotemporal distributions and trends in surface water salinity and identify key drivers of change in the coastal region of Bangladesh. The observed spatiotemporal structure in surface water salinity is primarily controlled by the magnitude and seasonality of river discharge entering the delta. In the moribund delta north of the Sundarbans, the contour between fresh and brackish water migrates seasonally between ~20 and ~40 km northward during the dry season. Abrupt increases in surface water salinity are observed throughout the coastal region in response to variations in upstream river discharge; the prominence of these events highlights their importance in driving salinity increases. Areas which are better connected to more voluminous seasonal river discharge (active delta), show greater recovery to these episodic inundations by cyclones than those less-well flushed by river discharge (moribund delta). Our reported observations provide a baseline for understanding the consequences of global environmental change and informing more climate-resilient adaptation strategies in coastal environments of Bangladesh and other Asian mega-deltas.

Abstract Humans continuously interact with physical, chemical, and biological environments that influence their health, safety, and quality of life. Sensing devices, such as electrochemical sensors that translate environmental qualities into electrical signals, are crucial for detecting biomarker concentrations in various biofluids. However, the understanding of electrochemical sensing is often incomplete, necessitating further study of chemical reactions and sensor‐electrode interactions for healthcare applications. This review analyzes crucial topics in chemical reactions in electrochemical sensing environments. First, the dynamics of chemical energy, the roles of acidic and alkaline fluids, chemical reaction tendencies, thermodynamic equilibria, Gibbs free energy, water dissociation, and the pH scale are discussed. Sensor materials or biomarkers undergo oxidation and reduction reactions in electrochemical sensing. Oxygen‐derived radicals and nonradical reactive species significantly influence biochemical reactions, cellular responses, and clinical outcomes. Then, the review delves into the impact of oxidation reduction reactions on human pathophysiology, redox reactions in hemoglobin, redox environments in human serum albumin and cells/tissues, and thermodynamics of biological redox reactions. Finally, recent advances in electrochemical techniques are presented and research challenges and future perspectives in electrochemical sensing for health applications are addressed.

A proper assessment of the water allocation system and water–food production relationships is essential to identify water use reduction potentials and enhance crop water productivity in dry areas. However, limited data on crop-specific water uses and water losses in the system, especially in developing and transition countries, prevent consistent diagnosis of issues in water systems. A modeling framework based on maximum entropy approach was implemented here to simultaneously assess water system structure and ‘water use-crop production’ relationships. The framework allowed for the analysis of long-term changes in conveyance efficiency, crop-specific water application, and irrigation water productivity between 1980 and 2021 in the Khorezm region in the lower reaches of the Amu Darya Basin in Central Asia. The results showed that conveyance losses were more than 30% in the system, and approximately 40% of the water allocated to the region went to rice and cotton production, indicating the possibility of water use reduction in these three areas. Conveyance efficiency and cotton water productivity improved in drier years in the region, owing to the wide implementation of temporary and low-cost drought management measures. The expected increase in the frequency and magnitude of droughts may require long-term investment-demanding strategies for drought management to enhance the sustainable livelihoods in the region.

Aim to evaluate the correlation between the course of vertebral arteries and veins and the results of calculations of hemodynamic parameters during ultrasound with functional tests. Material and methods. In the observation, 252 volunteers were examined using Samsung SonoAce R7 and GE Logiq F6 equipment. The hemodynamics was studied at the level of the second segment of the vertebral arteries and veins at rest, when turning, tilting and lifting the head. The results were processed using Microsoft Excel 2007 with subsequent statistical analysis. Results. 504 vascular complexes were analyzed without taking into account the visualization side. When assessing the arteries, the highest maximum blood flow velocity was registered when lifting the head in women with a rectilinear course of the vessels. In the group of men with non-rectilinear course of vessels, the lowest average blood flow velocity was registered when tilting the head. The highest volume flow was recorded in case of non-rectilinear vascular course in women when lifting the head. For vertebral veins, the highest indicators of maximum and minimum venous blood flow rates were observed in men with a rectilinear course of vessels when lifting the head. The highest values of the average flow velocity and volume flow were noted in men who had a rectilinear course of the vessels. The maximum values of the calculated venous volume flow were registered in groups with rectilinear vascular course: in men up to 19.4214.85 ml/min. (Me 12.45 ml/min.), in women 18.52 15.30 ml/min. (Me 10.50 ml/min.). Conclusion. The data obtained by the study contributes to improving the software and analysis of individual changes during patient examination, helps to evaluate the effectiveness of treatment and rehabilitation, as well as to analyze multifactorial models.

Landslides pose a serious risk to life and property in the mountainous regions around the globe. Understanding the interplay of landslide conditioning and triggering factors is essential for lessening the impacts caused by the hazard. Cox's Bazar — a coastal mountainous district in Bangladesh is recurrently affected by rainfall-triggered landslides. Based on analysis of 14 experiential landslides and combination of gauged and satellite rainfall estimates for the period from 2003 to 2019, the present study determines three landslide-triggering rainfall thresholds for the Cox's Bazar District (CBD): 1. Intensity-Duration (ID) threshold derived in this study revealed that any rainfall event with an intensity of ≥4.04 ​mm/h if prolonging for ≥12h can cause slope failures; 2. Event-Duration (ED) threshold suggested that a normalized cumulative event rainfall (EMAP) of 0.15 for one day is expected to trigger landslides; and 3. threshold calculated using randomly chosen antecedent rainfall expressed best distinction on 30-day rainfall and the equation of the threshold came out as Rth ​= ​64–0.02 Ra30. The recurrence probability of the derived antecedent rainfall threshold and likely landslides was determined through the Poisson distribution. Moreover, we assess the landslide susceptibility of the district with a coupled use of Frequency Ratio (FR) statistical measure and Geographic Information System (GIS). Considering the combined role of selected conditioning factors, the landslide susceptibility status of the CBD was quantified and classified into probability intervals. The accuracy of the susceptibility maps was assessed through the Relative Landslide Density Index (R-Index) that used a field landslide inventory, comprising well distributed 891 events. Moreover, gridded population data was superimposed on the derived susceptibility maps to understand the risk levels of people. The derivation of landslide-triggering rainfall thresholds and spatial susceptibility assessment has been useful to propose a low-cost Landslide Early Warning System (LEWS) which can contribute in alleviating the adverse effects of landslide hazard in the CBD.

Abstract Severe failure of improperly designed and poorly constructed structures may occur due to the amplified and prolonged ground motion during an earthquake, and hence prediction of the ground motion characteristics at the soil surface is crucial. In this study, based on the prepared simplified engineering geomorphic map, we performed a one-dimensional (1D) nonlinear site response analysis for seismic site characterization of the recently proposed Detailed Area Plan (DAP) area of Dhaka City, the Capital of Bangladesh. The engineering geomorphic unit-based map was prepared from image analysis and verified with the collected borehole data and surface geology map. The study area was classified into three major geomorphic units and seven sub-units subject to the subsurface soil profiles. Nine earthquake time histories, seven from the PEER NGA WEST2 data set and two synthetics, and seven identified subsurface soil profiles were used for nonlinear site response analysis, along with the BNBC 2020 uniform hazard spectrum as the target spectrum. For the selected earthquake ground motions, the near-surface soil response of the DAP area showed de-amplification of acceleration in the short period and amplification of acceleration in the long period. The amplified long-period acceleration could cause severe damage in inappropriately designed and poorly constructed long-period structures. The outcome of this study could be used to prepare a seismic risk-sensitive land use plan for the future development of the DAP of Dhaka City.

Abstract Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation.

RESUMO A interação entre Atenção Primária à Saúde (APS) e especializada é tão relevante quanto crítica. O cuidado às Pessoas Vivendo com HIV/Aids (PVHA), que era realizado em ambulatórios especializados, recentemente, passou a se dar também pela APS, considerando seu potencial de ampliar o acesso. A partir de estudo de caso realizado em uma região municipal do Rio de Janeiro entre 2018 e 2019, discutiu-se tal problemática, destacando como resultados: desconhecimento/hesitação dos profissionais da atenção especializada sobre a atenção básica quanto à sua capacidade de cuidar das PVHA; priorização de investimento material, simbólico e político na atenção básica; quase inexistência de canais de diálogo entre serviços; entre outros. Na experiência estudada, a interface entre APS e atenção especializada tem se dado mais em uma lógica binária e de isolamento que em uma perspectiva de interação e gestão (compartilhada) do cuidado, que seria esperada em uma conformação de rede de atenção. Apesar dos potenciais ganhos de acesso e ‘racionalização’ do uso do especialista (infectologista), tais resultados indicam a necessidade de fortalecer processos e mecanismos de comunicação e interação entre profissionais de diferentes tipos de serviços, além de dispositivos de coordenação dos cuidados, como apoio matricial e prontuário eletrônico integrado em rede.

β-lactamases are a diverse class of enzymes produced by bacteria that present a major cause for resistance to β-lactams. In this study we analysed 159 fecal samples from dairy cows, for the presence of presumptive ESBL, AmpC, and carbapenemase-producing E. coli. Phylotyping was done using Clermont phylo-typing method, targeting arpA, ChuA, and YjaA genes, along with the DNA fragment TspE4.C2. Convetional PCR method was used to confirm the presence of bla genes among 39 phenotypically confirmed ESBL producing E. coli. The results showed presence of CTX-M, SHV, TEM and OXA1 bla genes in 28 (71.79%), 1 (2.56%), 29 (74.35%), 2 (5.12%) of isolates, respectively Twenty (51.28%) isolates showed presence of both blaCTX-M and TEM genes. The strain that carried the blaSHV gene was found to carry blaTEM gene as well, while one of the strains that carried blaOXA1 gene was also carrying blaCTX-M and TEM gene. The ration between isolates and phylo-groups was as follows: 9 (23.07%) strains were assigned to phyllo-group D; 14 (35.89%) to phyllo-group B; 16 (41.02%) to phyllo-group A. Out of the 39 strains where bla genes were identified, 29 (74.35%) were categorized as multi drug resistant.

Seasonal variation observations were conducted in the coastal waters of St. Martin's Island in the Bay of Bengal to examine the influence of physical processes and the distribution pattern of nutrients in the ocean water. Pollution evaluation indices, health index and statistical techniques were incorporated to assess the heavy metal contamination. Two seasons, cool dry winter and pre-monsoon hot, were considered for sampling from 12 stations around the island. The Cool dry winter season has higher nutrient concentrations than the Pre-monsoon Hot season. The concentration of nutrients appeared as follows: Silicate > Nitrate > Ammonia > Phosphate > Nitrite. PCA and Pearson's Correlation showed that fresh water from nearby rivers, deep water upwelling, and, in some situations, modest anthropogenic sources are crucial. Hence, low DO and phosphate levels during the pre-monsoon hot season indicate there is a planktonic process like photosynthesis prevailing. The island's north-western and south-eastern regions have higher nutrient concentrations, which may be seasonal and due to wind action. Pb, Cu, As, Cr, Cd, and Zn were also considered to comprehend the island's geo-chemical perspectives and ecological and human health risks. The Pre-monsoon Heavy Metal Pollution Index (HPI) and Heavy Metal Evaluation Index (HEI) demonstrated that some places are much higher than the threshold limit, even though no significantly higher value was detected in the cool winter season. The Nemerow Index, the Total Ecological Risk Index (TERI), indicated that heavy metal contamination was severe to moderate and low to moderate. Finally, Pearson's correlation showed the association between physical and chemical characteristics, similar to PCA and Pearson's correlation for nutrients and heavy metals. Thus, this research may help shed light on the state of the seas around St. Martin's Island. This study may also provide explicit insights for the authority to take the necessary measures to preserve marine ecology and the associated terrestrial ecosystem.

Abstract Background Airway complications are frequent after lung transplantation (LT), as they affect up to 23% of recipients. The implication of perioperative extracorporeal membrane oxygenation (ECMO) support and haemodynamic instability has never been specifically assessed. The first aim of this study was to explore the impact of perioperative ECMO support on bronchial anastomotic dehiscence (BAD) at Day 90 after LT. Methods This prospective observational monocentric study analysed BAD in all consecutive patients who underwent LT in the Bichat Claude Bernard Hospital, Paris, France, between January 2016 and May 2019. BAD visible on bronchial endoscopy and/or tomodensitometry was recorded. A univariate analysis was performed (Fisher’s exacts and Mann–Whitney tests), followed by a multivariate analysis to assess independent risk factors for BAD during the first 90 days after LT (p

Objective: Resveratrol is a polyphenolic compound that possesses strong antioxidant and anti-inflammatory activities. This study evaluated the effects of resveratrol on oxidative stress, fibrosis and multiple genes regulation in the kidneys of high fat (HF) diet-fed rats. Methods: Wistar rats were fed with HF diet for eight weeks. These rats were also treated with resveratrol for eight weeks. Finally, kidney tissue samples were isolated from all sacrificed rats. The histological changes, creatinine and uric acid levels, oxidative stress parameters such as malondialdehyde (MDA), nitric oxide, and advanced oxidation protein product (AOPP) levels were analyzed. The antioxidant enzymes such as catalase, superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels; gene expression of inflammatory and fibrosis-related genes namely, inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta1 (TGF-β1), and collagen-1 were assessed. Moreover, gene expression of oxidative stress-related genes such as nuclear factor erythroid 2–related factor 2 (Nrf-2), SOD, catalase, and glutathione reductase, were also assessed. Results: HF diet-fed rats showed increased creatinine and uric acid levels in plasma which were lowered by resveratrol treatment. The study findings also revealed that resveratrol counterbalanced the oxidative stress and prevented the expression of the inflammatory genes; restored the catalase and SOD activities followed by the up-regulation of antioxidant genes expression in the kidneys of HF diet-fed rats. HF diet caused the Nrf-2 down-regulation followed by the decreased expression of HO-1 and HO-2 genes, which was restored by resveratrol treatment. Moreover, the histological assessment showed lipotoxicity and increased fibrosis in the kidneys of HF diet-fed rats. Resveratrol prevented the kidney fibrosis probably by limiting oxidative stress, inflammation, and down-regulating TGF-β1 mediated signaling pathway. Conclusion: In conclusion, resveratrol treatment showed beneficial effects in preventing oxidative stress and fibrosis in the kidneys of HF diet-fed rats probably by modulating the gene expression of oxidative stress and inflammation related factors and enzymes.

Bangladesh, a country that lies on the north shores of the Bay of Bengal, has been blessed with a plethora of natural resources. St. Martin's Island, the only coral island in Bangladesh, is undoubtedly regarded as one of the most prized possessions. It is rich in biodiversity, but truly scientific information on it is lacking. In the present investigation, 14 stations adjacent to St. Martin's Island within the Bay of Bengal were sampled for determining the composition, spatial distribution, species richness, and diversity of pelagic zooplankton. Samples were collected in the pre-monsoon hot season. From the community of zooplankton, 34 species were reported. Most of the species belonged to copepods. Besides, Polychaeta and Cirripedia were also present in the community. The most significant species belonged to Oithona, Canthocalanus, Balanus, Euterpina, and Microsetella. Total zooplankton standing crop varied from 45,000-125,000 ind/m3 and the highest number of species (8) were observed at station 7. Strong variability in the distribution of species was observed in the studied stations. The number of genera collected at each station varied from 4 - 8. Data on species richness (Df) varied from 1.30-3.04 and that of the Shannon-Wiener Index (H) from 1.33-1.93. The species composition of zooplankton and the species richness and the diversity index of the population was comparable to the other studies carried out in the Central and Western Bay of Bengal.

We have proposed a novel method for assessing landslide risk by applying cutting-edge geospatial technologies and combining hazard, exposure, and vulnerability components. The Kutupalong Rohingya Camp (KRC) in Cox's Bazar, Bangladesh, was taken as a case study area. The district was hosting over one million Rohingya refugees from Myanmar, fleeing genocide and crimes against humanity. Extensive vegetation removal, hill cutting, exceptionally dense camps, fragile shelters, unstable soils, and excess monsoon rainfall were linked to yearly landslides. At first, ten landslide factor maps were produced, and a detailed fieldwork-based landslide inventory was conducted. Next, we applied various statistical and knowledge-based approaches for landslide susceptibility modelling. The most accurate susceptibility map was utilised to produce landslide hazard maps for different rainfall return periods. Next, we used population and shelter density data for exposure mapping and integrated age and gender-based factors for social vulnerability analysis. The hazard, exposure, and vulnerability maps were combined to produce the landslide risk map. Finally, we calculated shelters and refugee populations at risk for different scenarios. Camp 10 had the highest risk value, and historical landslide events validated the results. This study is replicable in a similar context and can be scaled up. It provides authentic information on landslide disaster scenarios that should be adopted in the decision-making process to reduce future impacts of catastrophic hydrometeorological disasters in the KRC and surrounding host community areas.

Abstract This article critically investigates a catastrophic rainfall-induced landslide event that occurred on 27 July 2021 in the Kutupalong Rohingya Camp (KRC) in Cox’s Bazar, Bangladesh, from geological and geomorphological perspectives. Large-scale anthropogenic interventions mainly caused the disastrous landslide event in the KRC in addition to intense rainfall. Before the landslide occurrence, about 300 mm of cumulative rainfall was recorded in the previous seven days and 120 mm of rainfall during the landslide event. A preliminary investigation was conducted to understand the extent, causative factors, and landslide characteristics. The landslide is of mud-flow type, but on the nearby slope, slumping was also visible. The landslide length was about 33 m, width 31 m, and area 612 m2. The approximate volume of slope materials displaced during the landslide event was about 2450 m3. The displaced slope materials mainly were silt and sand. The landslide event caused five fatalities and damaged nearly 5000 shelters in the KRC area. The devastation from such a small landslide event was attributed to dense households on the slope’s hilltop, slope, and toe. The camp areas and host communities are subjected to frequent and fatal landslides in the years to come due to intense human interventions and climatic conditions. The modifications of the slopes have been reducing the cohesion and the shear strength of the slope materials. Therefore, it is recommended to undertake proper mitigation and preparedness measures, including developing and implementing a landslide early warning system to address the emerging humanitarian crisis in the KRC and its surroundings.

Objective: The aim of this study was to evaluate the post-marketing safety, tolerability, immunogenicity and efficacy of Bevacizumab (manufactured by Hetero Biopharma) in a broader population of patients with solid tumors. Patients And Methods: This phase IV, prospective, multi-centric clinical study was carried out in Indian patients with solid malignancies (metastatic colorectal cancer, non-squamous non-small-cell lung cancer, metastatic renal cell carcinoma) treated with Bevacizumab between April 2018 and July 2019. This study included 203 patients from 16 tertiary care oncology centers across India for safety assessment, of which a subset of 115 patients who have consented were also evaluated for efficacy and immunogenicity. This study was prospectively registered in the Clinical Trial Registry of India (CTRI), and was commenced only after receiving approval from the competent authority (Central Drugs Standard Control Organization, CDSCO). Results: Out of the 203 enrolled patients, 121 (59.6%) patients reported 338 adverse events (AEs) during this study. Of 338 reported AEs, 14 serious adverse events (SAEs) were reported by 13 patients including 6 fatal SAEs, assessed as unrelated to the study medication and 7 non-fatal SAEs, 5 assessed as related, and 3 unrelated to Bevacizumab. Most AEs reported in this study (33.9%) were general disorders and administration site conditions, followed by gastrointestinal disorders (29.1%). The most frequently reported AEs were diarrhea (11.3%), asthenia (10.3%), headache (8.9%), pain (7.4%), vomiting (7.9%), and neutropenia (5.9%). At the end of the study, 2 (1.75%) of 69 patients reported antibodies to Bevacizumab without affecting safety and efficacy. However, at the end of 12 months, no patient had reported antibodies to Bevacizumab. Complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were reported in 18.3%, 22.6%, 9.6%, and 8.7% of patients, respectively. The overall response rate (CR + PR) was reported in 40.9% of patients at the end of the study. Disease control rate (DCR), also known as the clinical benefit rate (CBR) was reported in 50.4% of patients. Conclusions: Bevacizumab (Cizumab, Hetero Biopharma) was observed to be safe, well tolerated, lacking immunogenicity, and efficacious in the treatment of solid tumors. The findings of this phase IV study of Bevacizumab, primarily as a combination therapy regimen suggest its suitability and rationality for usage in multiple solid malignancies. Clinical Trial Registry Number: CTRI/2018/4/13371 [Registered on CTRI http://ctri.nic.in/Clinicaltrials/advsearch.php : 19/04/2018]; Trial Registered Prospectively.

The article delves into the pressing issue of soil contamination by heavy metals, providing a comprehensive overview of how elements like lead, cadmium, and zinc accumulate in soil environments. Highlighting the extensive factors that contribute to this accumulation, it draws attention to the industrial activities, agricultural practices, and environmental pollution, especially from vehicular emissions along highways, that significantly contribute to the problem. The negative impact of heavy metals on soil health is a focal point, with specific emphasis on the decline in soil's biological activity and the reduction in levels of vital nutrients such as nitrogen, in both ammonium and nitrate forms, which are crucial for plant growth and soil fertility. Moreover, the article sheds light on the consequences of heavy metal accumulation not only on soil health but also on the broader ecosystem and human health, considering the potential for these metals to enter the food chain. It specifically mentions the findings from scientific studies conducted in the soils of the Surkhandarya and Namangan regions of the Republic of Uzbekistan, as well as in districts of the Republic of Karakalpakstan. These studies reveal concerning levels of heavy metal contamination that exceed permissible norms (PN), indicating a significant environmental issue that requires urgent attention.

The purpose of this work is to create a three-dimensional model of the terrain on the territory of the Hasti-Imam ensemble of the city of Tashkent (Uzbekistan), using a Geoscan 401 multi-rotor unmanned aerial vehicle and a modern photogrammetric product Agisoft Metashape. Four flights were performed at this facility using a Geoscan 401 quadcopter. Aerial photography was carried out at different heights (from 40 m to 100 m) and with different inclinations of the aerial camera (45°, 60°, 90°) in order to display all elements of the ensemble in more detail. Aerial photography was carried out at a scale of 1:500 using a SonyDSC-RX1 digital aerial camera with a focal length of 50 mm. The longitudinal overlap of aerial photographs was from 70% to 80% and, accordingly, the transverse overlap was also from 70% to 80%. The number of aerial photographs at the site was 936 pieces. The length of all air routes was 65.9 km. The area of the filmed object was 14 hectares.The processing of unmanned aerial photography and the construction of a three-dimensional model of the terrain on the territory of the Hasti-Imam ensemble in Tashkent, Uzbekistan was carried out in the modern photogrammetric complex Agisoft Metashape.

The purpose of the work under study is to create a three-dimensional model of a landslide on a dangerous section of the left bank of the Akhangaran reservoir, which is located in the Angren district, Tashkent region of the Republic of Uzbekistan, using unmanned aerial photography. In order to display the landslide area in as much detail and accuracy as possible, aerial photography was carried out by a Phontom4 pro multi-rotor unmanned aerial vehicle (Chinese company DJI) with a 4K camera and an object tracking function. camera DSC-RX1R with a focal length of 35 mm over an area of 162 hectares. Four 1:500 scale aerials were completed on site, with a longitudinal overlap of 70% and a transverse overlap of 50%. Aerial photography was carried out at an altitude of 70 meters. The total number of aerial photographs was 936. The length of all air routes was 122.7 km. The article examines in great detail the functions of the quadcopter, the uniqueness of its camera, which is capable of shooting video in 4K format (4096 by 2160 pixels) at a speed of 60 frames/sec, as well as taking 14 photos per second in burst mode, and at the same time broadcasting video picture to a synchronized tablet or phone. For the first time in a DJI camera of this size, a mechanical shutter is used, which allows you to shoot dynamic scenes without the “jelly effect”, and it is also noted that an improved battery with a capacity of 5350 mAh increased the drone’s flight time to almost 30 minutes. The paper notes the purpose of the Agisoft Metashape software, in which aerial photography materials were processed, and also describes the technology for creating a 3D model for the landslide section of the left bank of the Akhangaran reservoir.

The use of antimicrobials in livestock production and their effect on the development of antimicrobial resistance (AMR) is a global health problem for humans, animals and the environment. The aim of this study was to determine antimicrobial residue levels in milk and feces samples during the withdrawal period in dairy cattle administrated with a single dose of the drug, as well as to characterize the antimicrobial resistance patterns of Escherichia coli cultured from feces samples. In the study, dairy cows from three different farms in North Macedonia were included. Raw milk and feces samples were collected before drug administration (0 day) and on the 1st, 2nd, 3rd, 7th and 21st day after drug administration. The antimicrobial residues of oxytetracycline, enrofloxacin, amoxicillin, trimethoprim and procaine-benzylpenicillin were determined using a validated liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) method involving stable isotopes. According to results obtained, the highest levels of analyzed antimicrobial residues were determined on the first day after drug administration, which then gradually decreased until their elimination (7th day). The highest AMR of E. coli (100%) was found in β-lactam antimicrobials. Less exposure to broad-spectrum antimicrobials could be an important factor for reduction of AMR on dairy farms.

Abstract The prevalence of myopia is growing at an alarming rate and is associated with axial elongation of the eye. The cause of this undesirable physiological change involves multiple factors. When the magnitude of myopia approaches high levels, this accompanying mechanical effect increases the risk of developing other clinical conditions associated with permanent vision loss. Prior work has investigated how we may halt or reverse this process of axial elongation associated with myopic progression when we expose the eye to a peripheral myopic defocus stimulus. Specifically, the known, short-term response to myopic defocus stimulation is promising and demonstrates the possibility of establishing more permanent effects by regulating the axial length of the eye with specific defocus stimulation. However, how to directly convert these known, short-term effects into more long-term, permanent changes to effectively prevent these unfavourable physiological and refractive changes over time is yet to be understood. Here, we show for the first time that we can produce sustained, long-term reductions in axial length and refractive endpoints with cumulative short-term exposure to specific myopic defocus stimuli using a novel optical design that incorporates an augmented reality optical system. We believe that this technology will have the potential to improve the quality of vision in mankind.

Controlling blast action, in order to increase its energy efficiency in a production blasthole is quite an important issue. This is because it enables the formation of broken rock mass with preset coarseness parameters. Increasing the blast pressure and the time of the blast impact on a rock mass is traditionally recommended as one of the ways to improve the blast action on the rock mass, thus reducing the oversize yield in open pits. One device which enables this approach to a certain extent is a turbulator. The turbulator is fabricated of aluminum plate twisted in a helical fashion around its longitudinal axis. It is mounted in a production blasthole according to a specially designed scheme. The methodology developed to study the stress and strain state of a rock mass when using a turbulator in a blasthole explosive charge allows the size of radial fracture zone and the radius of rock fragmentation to be defined. A method was developed to initiate blasthole charges in a pit blasting block. It includes drilling blastholes, filling them with explosive, installing downhole blasting caps, and blasting using non-electric initiation system. A blasting block is divided into two equal parts (sections), which in turn contain three series of blastholes for short-delay blasting. Blasthole charges are initiated simultaneously in the two parts of the block based on a trapezoidal blasting pattern, thus ensuring meeting detonation waves. In the first series, instantaneous blasting of blastholes located on both ends of the blasting block and forming a trapezoid (in plan view) is carried out. Then after 42 ms, the second series of blastholes (also forming a trapezoid) is detonated. After another 42 ms, the remaining blastholes are detanoated along the perimeter of the blast block in the third series. Implementation of this design with the effect of turbo-blasting for rock fragmentations by blasthole charges at the Kalmakyr deposit of JSC “Almalyk Mining and Metallurgical Complex” has led to the reduction of consumption of explosives, volume of drilling, secondary fragmentation costs, and increased productivity of excavators and mining safety.

Multi-class and multi-residue analyses are very complex procedures because of the physico-chemical properties of veterinary drug residues and other contaminants. The purpose of the study was to develop an analytical method for the sensitive determination of 69 analytes in bovine milk by liquid chromatography electrospray ionisation–tandem mass spectrometry.

RESUMO A ampliação do papel da Atenção Primária à Saúde (APS) no tratamento de Pessoas Vivendo com HIV/Aids (PVHA) tem potencial de expandir o acesso ao cuidado de saúde. Este artigo visa analisar implicações da descentralização da assistência de PVHA para a APS na (re)produção ou redução de vulnerabilidades. Os conceitos de violência simbólica; interseccionalidade; precariedade e vulnerabilidades orientaram a entrada em campo e a análise dos resultados. Foram realizados grupos focais com profissionais, observação participante e entrevistas semiestruturadas com usuários e profissionais de duas unidades de APS na região central do município do Rio de Janeiro. Como principais resultados, destacam-se as implicações das vulnerabilidades associadas à violência armada e às questões de gênero no cuidado em saúde das PVHA, a existência de efeitos paradoxais da lógica territorial, bem como tensões entre a organização do processo de trabalho na APS e as necessidades/expectativas de usuários. Concluímos que a ampliação do acesso coexiste com a produção de novos riscos, que refletem na continuidade e qualidade do cuidado. Sublinhamos a necessidade de fortalecimento das interações trabalhador-usuário e da reflexão sobre novos arranjos para a organização dos processos de trabalho, que resultem em mais proteção e cuidado às pessoas, evitando a ampliação de vulnerabilidades.

Aim: To evaluate pharmacokinetics, efficacy and safety of fixed-dose combination (FDC) of oral capecitabine + cyclophosphamide in metastatic breast cancer (MBC) patients progressing after anthracycline and/or taxane chemotherapy. Methods: In this prospective, adaptive, phase-2/3, open-label study (CTRI/2014/12/005234), patients were randomized (1:1:1) to three FDC doses (doses/day: D1, capecitabine + cyclophosphamide 1400 mg + 60 mg; D2, 1800 mg + 80 mg; D3, 2200 mg + 100 mg) for 14 days, in 21-day cycles. In Part-I, multiple-dose pharmacokinetics and optimal dose(s) were evaluated with futility analysis. Group(s) with

Abstract This study assessed axial length and choroidal thickness changes following short-term peripheral myopic defocus in normal adult subjects. Twenty subjects underwent defocus sessions by viewing a full-field projected movie 4 m away for 4 h in the morning, while wearing spectacle lenses, corrected for distance vision in both eyes. The right eye, serving as the test eye, was peripherally defocused using a Fresnel lens overlay of + 3.50 D with a central clear aperture of 11.5 mm (correlating to a clear central visual field of approximately 23°), while the left eye served as the control (with no Fresnel lens overlay). A subset of 10 subjects from the same cohort also underwent additional defocus sessions with + 5.00 D of peripheral defocus. Axial length was measured and radial sub-foveal choroidal scans were obtained before and after the defocus sessions. The increase in axial length of the test eyes were significantly less than the control eyes under both peripheral defocus conditions (p

A editoria científica constitui prática socialmente valorizada, modulando trajetórias acadêmicas. Revistas científicas atuam entre dois campos sociais distintos, o editorial e o científico, tendo como eixo as relações objetivas e intersubjetivas do campo científico. O presente artigo analisa a atuação dos editores de Ciências Sociais do campo da Saúde Coletiva e suas concepções acerca do processo de avaliação de artigos científicos, sua visão e relação com os demais agentes da prática editorial e seu papel na conformação de um habitus científico. A opção metodológica foi a análise temática de 13 entrevistas semiestruturadas com editores(as)-chefes e associados(as) da área de Ciências Sociais de revistas de destaque da Saúde Coletiva. Os editores são agentes que operam com as contradições e pressões derivadas do produtivismo numa relativa autonomia da prática editorial. Gradativamente conformam um habitus editorial cunhado pela prática empírica, formação autodidata e dedicação voluntária. Estabelecem o diálogo entre os autores e a comunidade de pares-concorrentes do campo. Delimitam objetos e temas de interesse da área a partir da legitimidade assentada no agir “desinteressado” que demanda o campo científico. Impõem barreiras aos artigos considerados de baixa qualidade, definida especialmente por lacunas teórico-metodológicas e falta de originalidade. No entanto, seu trabalho didático de inculcar um modo considerado adequado no manejo de teorias e metodologias das Ciências Sociais se encontra circunscrito à recusa dos textos, o que sugere a importância de maior articulação entre editores, fóruns de editores, programas de pós-graduação e demais agentes de formação de pesquisadores do campo.

A cryptotephra belonging to the Upper Pleistocene volcanism of the Bas-Vivarais was identified for the first time in the sedimentary infilling of the entrance area of the Chauvet-Pont d’Arc cave. This slightly reworked tephra fall is characterized by its heavy minerals assemblage, among which magnesian olivine, enstatite, and chromian diopside issued from peridotites and olivine and diopside of basaltic origin. This composition likely refers to a phreatomagmatic eruption of a maar crater. The 14C datings of the cryptotephra beds are contemporaneous with the Aurignacian settlement and paintings, that is, an age slightly older or close to 36 ka. Among the maar craters from the Bas-Vivarais, the Ray-Pic maar have the closest 40Ar/39Ar age ($36.2 \pm 11.3/32.2 \pm 11.1$ ka). By contrast, the Vestide du Pal, the biggest maar crater of this country, seems to have a younger age, but the 40Ar/39Ar dating was measured on a basalt which could have occurred later and been the source of the tephra fall, since its tephras contain the same minerals of unknown origin as those found in Chauvet cave. This discovery strengthens the previous hypothesis according to which the humans living in the Chauvet-Pont d’Arc area during the Upper Paleolithic have witnessed eruptions from the Bas-Vivarais volcanic field and other phenomena.

Resumo: A profilaxia pré-exposição ao HIV (PrEP) tem sido considerada uma estratégia fundamental para o controle da epidemia de HIV/aids, e desde 2018 tem sido objeto de estudo de implementação (Estudo ImPrEP Stakeholders), realizado no Brasil, no México e no Peru. Um componente qualitativo desse estudo foi desenvolvido com o objetivo de identificar os contextos sociais e estruturais que envolvem e organizam a oferta de serviços de PrEP no Brasil, as subjetividades dos atores envolvidos e as diferentes percepções que podem impactar a efetivação dessa estratégia. O presente artigo teve como foco de análise o acesso das populações vulneráveis aos serviços de PrEP, na perspectiva de gestores, profissionais de saúde, lideranças ou ativistas e usuários de PrEP. É um estudo qualitativo com o uso de metodologia compreensiva, realizado em seis capitais brasileiras, em que foram entrevistados 71 atores-chave no período de novembro de 2018 a maio de 2019. A análise foi pautada pelos modelos analíticos sobre acesso propostos por Giovanella & Fleury, McIntyre et al. e Penchansky & Thomas. Os resultados são apresentados com base em três eixos: “percepções sobre prevenção combinada e PrEP”; “disponibilidade e adequação: perfil e estrutura dos serviços no contexto do ImPrEP”; e “aceitabilidade: atitudes e práticas dos profissionais de saúde e usuários”.

This article discusses the importance and principles of hydraulic calculations in in non-pressurized pipelines. The main hydraulic elements of flow in a non-pressurized pipe are determined depending on the radius of the pipe. The most efficient hydraulic cross section R=f(h) for fluid flow in a non-pressurized pipe was scientifically substantiated for the depth and diameter of the flow through a functional relationship.

According to experts, an individual's diet has a more significant impact on their health, around 90%, compared to healthcare services, which only impact about 10%. Certain elements like iron, copper, zinc, molybdenum, and trace elements play a crucial role in the biological functions of plants, animals, and humans. The study was carried out through both field and laboratory experimentation, following methodological manuals such as “Methods for agrochemical analysis of soil and plants”, “Methods for agrophysical research” and “Methods of conducting field experiments”. It was found that the aquifer also had a low content of alkalinity (NSO3) at 0.024%, chloride ions at 0.007%, and sulfate ions at 0.027%, indicating that it is a chloride-sulfate salinity type. The next layers showed a total amount of easily soluble salts in water ranging from 0.065-0.085%, with a total alkalinity of 0.024%, chloride ion content at 0.004%, and sulfate ion content ranging from 0.016-0.023%

This article presents the results of experiments on the physical processes that occur during the hardening process of concrete in dry hot-climatic seasons and the reduction of their negative effects - as well as on the physical and mechanical properties. Under the influence of solar radiation and high temperature, the amount of water in the newly laid concrete mixture begins to evaporate rapidly. As a result of intensive evaporation of water in the concrete mixture from the bottom to the top, interconnected pores are formed, as a result of which the concrete has a defective structure, and this situation leads to a decrease in concrete strength. As a result of dehydration of the concrete mixture, the cement hydration process slows down and may even stop. If the hardening of the concrete is not adequately controlled, its strength may be only 50% of the design strength. The duration of keeping newly laid concrete under polymer films is determined by the construction laboratory, taking into account specific climatic conditions. Covering the concrete surface with inventory thermal insulation coatings (ITVP). These covers are made by pulling two-layer polyethylene film on wooden or metal frames. They can also be folded and assembled. The effectiveness of this method is not very high, it is considered a waste product.

Diabetes is a chronic disease, which is the seventh leading cause of death worldwide. The increased risk to the health of diabetic patients, with comorbidities in harsh situations like COVID-19 pandemics, necessitates real-time monitoring of blood glucose. Monitoring of blood glucose is invasive, hence, sweat glucose monitoring can be an alternative approach to address the invasive issue in blood glucose monitoring. This work reports a facile, low-cost, high-performance copper (Cu) native oxide (CuNOx)-based nonenzymatic electrochemical sensor for sweat glucose sensing. We utilized a very thin Cu native oxide of ~10 nm on Cu thin film for the sensing because of the excellent catalytic oxidation behavior of cuprous oxide (Cu2O) to glucose. The anodic sweep of cyclic voltammetry of glucose showed that the hydroxyl ions from sodium hydroxide convert the electrode surface into different oxides [Cu(I), Cu(II) Cu(III)], which electro-oxidize glucose to gluconolactone, then eventually to gluconic acid resulting in oxidation current. The CuNOx sensors exhibited a sensitivity of 603.42 μA mM−1 cm−2, a linear range beyond the desired limit of 7.00 mM with excellent linearity, and a low limit of detection of 94.21 μM. Excellent repeatability and stability (stable >1 year) with relative standard deviation (RSD) of 2.67%, and 2.70%, respectively were achieved for 1 mM glucose. The selectivity with common interferants of glucose in human sweat and blood showed an RSD of 3.56%. We believe the electrocatalytic efficacy of the CuNOx sensors for glucose sensing can open a new prospect in the fabrication of wearable sweat glucose sensors.