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This study describes the methodology and main results obtained after applying several geomatic techniques, based on the fusion of data acquired by several sensors, to document the recovery works carried out in an abandoned church. A century ago, the façade was moved to a museum to ensure its preservation. In addition to documentary purposes, a secondary goal is the virtual repositioning of a model of this element on that of the church. The method takes advantage of the potential of each technique, considering the acquisition of geometry based mainly on laser scanning techniques and radiometry on photogrammetry. The results include 3D models and orthoimages, which are used to perform a stratigraphic study. The 3D model of the façade has been repositioned in the general one, considering common geometries previously fitted in both models and repeating part of the photogrammetric process, using masks to define the image areas related to the church and the façade. Therefore, we obtained a 3D model with the façade included in it. This procedure has demonstrated its feasibility despite the existence of different environmental conditions in both areas. Using these results, we have also developed a BIM to allow for the management of future restoration works.

Abstract Hot Flow anomalies (HFAs), one of the most well‐analyzed transient phenomena in the Earth's foreshock, are known as kinetic structures driven by tangential discontinuities (TDs). Recently, a 2‐dimensional (2D) magnetohydrodynamics (MHD) model reproduced HFAs with either a high‐ or low‐density core. Further investigation of an HFA with two cores observed by the Magnetospheric Multiscale (MMS) mission is reported. The observation via the Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon's Interaction with the Sun (ARTEMIS) mission suggests this MHD HFA is associated with a foreshock density hole‐like structure. The trailing flux tube in simulation may propagate with a TD in the foreshock. Our work suggests that HFAs with two low‐density cores can also be achieved in MHD process. Results show the total ram pressure can be an excellent diagnostic for the presence of transient structures, such as HFAs, at the bow shock.

The development of information technologies and use of mobile devices that help establish direct contacts at a distance became an integral part of people life and tools of conducting today’s business. These factors promote the development of mobile marketing, a new and promising trend of work, which is characterized by interactive contact with target audience beyond space limits. There are a lot of investigations and publications dealing with different aspects of mobile marketing, however the problem of tools of mobile marketing stirs high interest of academic community. The goal of the article is to research the role of technology and tools of mobile marketing in shaping key metrics of estimating efficiency of its elements. The author studied the totality of mobile marketing elements, characterized voice services of support, SMS, MMS, e-mail promotion, mobile applications, described stages of developing mobile applications, showed variants of mobile adverts in advertising and social networks, identified the role of mobile marketing in elaborating strategy of customer moving along the marketing funnel, until the target step interesting for the company is made, analyzed practice of using mobile marketing in restaurant business, found key competitive advantages, which are obtained by the organization by introducing events of mobile marketing, described groups of metrics for estimating mobile traffic in efficiency of mobile marketing elements in the enterprise functioning (cost, conversion nature of adverts, investment return, customer activity and involvement). Academic findings and conclusions of the research can be useful both for management of Russian companies in elaborating strategy of reaching competitive advantage on market and representatives of other professional communities interested in using tools of mobile marketing. Research methods combined comparative and systematic analysis, qualitative and quantitative approaches.

To achieve a domestically developed alternative to the manufacturing message specification （MMS） as the core communication technology for the substation control layer， the State Grid Corporation of China has established the communication message specification （CMS） for secondary systems in substations. However， the specific application implementation plan has not yet been provided. Therefore， to promote the application of the CMS protocol and advance research on the independent and controllable core technology of substations， a solution is proposed to implement the application of the CMS protocol on a new generation of independent and controllable embedded protection devices. The solution outlines specific implementation methods， including encoding and decoding， communication structure， compatibility application of CMS and MMS， as well as communication security. The feasibility of the solution has been verified through service consistency testing and code robustness testing. The solution has been applied in the new generation of independent and controllable product platforms.

Latar Belakang: Tingkat kepatuhan merupakan indikator keberhasilan program pemberian MMS maupun TTD. Faktor yang dapat mempengaruhi tingkat kepatuhan yaitu tingkat pengetahuan, daya terima konsumsi, daya terima karakteristik, dan dukungan keluarga. Tujuan: Menganalisa hubungan dan perbedaan tingkat kepatuhan dalam konsumsi MMS maupun TTD pada ibu hamil di wilayah kerja Puskesmas Mulyorejo Surabaya. Metode: Penelitian observasional dengan desain kohort prospektif. Terdapat dua kelompok sampel yaitu kelompok konsumsi MMS dan kelompok konsumsi TTD dengan jumlah 24 sampel tiap kelompok yang dialokasikan secara random dan dipantau selama 30 hari. Variabel independen yaitu jenis suplemen sedangkan dependen yaitu tingkat kepatuhan. Variabel luar terdiri dari tingkat pengetahuan, efek samping, daya terima konsumsi, daya terima karakteristik, dan dukungan keluarga. Analisis perbandingan menggunakan Mann Whitney sedangkan analisis hubungan menggunakan uji chi square. Hasil: Rata-rata tingkat kepatuhan ibu hamil konsumsi MMS lebih tinggi yaitu 79% dibandingkan dengan TTD yaitu 71,2%. Namun, tidak ditemukan perbedaan yang signifikan diantara keduanya (p-value=0,400). Tingkat pengetahuan, daya terima konsumsi, dan daya terima karakteristik tidak ditemukan perbedaan yang signifikan (p-value>0,05). Rata-rata dukungan keluarga kelompok MMS lebih tinggi yaitu 34,9 dibandingkan kelompok TTD yaitu 32,2. Tingkat pengetahuan dan daya terima konsumsi berhubungan dengan tingkat kepatuhan (p-value0,05). Kesimpulan: Tidak terdapat perbedaan yang signifikan antara tingkat kepatuhan, tingkat pengetahuan, dan daya terima pada kelompok MMS tetapi rata-rata dukungan keluarga kelompok MMS lebih tinggi daripada kelompok TTD. Tingkat pengetahuan dan daya terima konsumsi berhubungan dengan tingkat kepatuhan. Namun, tidak dengan dukungan keluarga.

Abstract We report in situ observation of magnetic reconnection between magnetic flux rope (MFR) and magnetic hole (MH) in the magnetosheath by the Magnetospheric Multiscale mission. The MFR was rooted in the magnetopause and could be generated by magnetopause reconnection therein. A thin current sheet was generated due to the interaction between MFR and MH. The sub‐Alfvénic ion bulk flow and the Hall field were detected inside this thin current sheet, indicating an ongoing reconnection. An elongated electron diffusion region characterized by non‐frozen‐in electrons, magnetic‐to‐particle energy conversion, and crescent‐shaped electron distribution was detected in the reconnection exhaust. The observation provides a mechanism for the dissipation of MFRs and thus opens a new perspective on the evolution of MFRs at the magnetopause. Our work also reveals one potential fate of the MHs in the magnetosheath which could reconnect with the MFRs and further merge into the magnetopause.

Modern engineers face the challenges of complexity, uncertainty and ambiguity as three fundamental aspects of post-industrial technology. Hence, meta-subjective cognitive skills, critical thinking and creativity become no less important than professional knowledge acquired in vocational training. The better conditions for the development of these skills can be found if a contextual approach in teaching/learning is incorporated into the engineering curriculum. The article discusses the strategies for involving students in active learning activities while studying Mechanism and Machine Science (MMS) and developing students' cognitive competencies and metacognitive skills. Following the contextual approach, one can find that the simulation of mechanisms and the use of virtual labs form a powerful methodology to help learners better understand theory concepts. They provide students with a means of deeper numerical analysis and stimulate independent learning activity. Simulation and modeling of MMS products contribute greatly in students' comprehension of kinematics and dynamics of mechanisms. Another milestone of contextual approach is a creative problem-based learning that has been shown to be effective in education. However, creative problem-based learning is not in a focus of MMS courses yet. Brainstorming, TRIZ (theory of inventive problem solving, it sometimes occasionally goes by the English acronym TIPS), Synectics, and other creative problem-solving methods can be adapted for the active MMS learning. The article suggests the adaptation of SCAMPER, a method for solving several problems concerning structural analysis, kinematics, and gear trains.

Betatron acceleration is commonly cited as a primary accelerator of energetic electrons at dipolarization fronts, and many case studies compare observed energetic electrons measurements to a betatron model. In this work, we extend this to a statistical study. We identified 168 dipolarizations with an enhanced flux of energetic electrons at Magnetospheric Multiscale (MMS). We compared the observed flux of energetic electrons above 1 keV to a betatron acceleration model assuming a source population similar to the population in the quiet plasma sheet and found that, on average, the model slightly overestimated the observation, but there was a wide spread of errors. We then tested characteristics such as position, change in and strength of magnetic field, and wave power to determine if any of these characteristics affected the accuracy of the model; the only clear correlations were that the model was less accurate when the initial total magnetic field was smaller and when there was a higher Ey during the dipolarization. Since the betatron model did not explain our observations very well, we repeated with a full adiabatic model that included a Fermi acceleration component as well. We found that the adiabatic model slightly underestimated the observations, but with a smaller error than the betatron model under the same assumptions. Testing the same parameters, we found that the adiabatic model also did not strongly rely on any of the parameters except the initial magnetic field, and the anti-correlation with Ey was no longer present. The fact that neither model was generally applicable means that either adiabatic processes alone are not enough to explain electron acceleration at dipolarization fronts in general, or the common assumption we used, that the source population has the same phase space density as the cold pre-existing population, is not valid.

The current deployment of 5G NR in the frequency band 4800–4990 MHz in multiple countries near the coastlines indicated that there might be a potential risk of harmful interference impacting aeronautical and maritime systems located in international airspace and international waters. This raised numerous concerns about whether 5G NR system rollouts in that band need to be restricted by the power flux density limits created at the border of the territorial waters, which equals 12 nautical miles from the coastline. This work contains a case study based on the example of the Pacific region, where a simulation of aggregate interference from 5G NR base stations and user equipment deployed in the cities near the coastline using Monte Carlo analysis was conducted. The results of the study show that no harmful interference to the aeronautical and maritime services operating in international airspace and waters is expected even when the aircraft or vessels are located at the border of the territorial airspace and waters from the coastline. Therefore, no restriction to the 5G NR deployment in the coastline regions in the frequency band 4800–4990 MHz is required.

Um produto conhecido pela sigla MMS (do inglês Mineral Miracle Solution) ganhou a atenção da mídia brasileira em maio de 2019 após ter sido associado como falsa cura para o autismo, apesar de não haver evidências científicas de sua eficácia e diversos relatos associados às consequências negativas de seu uso. O objetivo deste estudo foi analisar vídeos do YouTube que estimulavam ou não o uso da substância antes e após as reportagens. Foram analisados 88 vídeos selecionados pelo filtro de relevância e em aba anônima. A maior parte dos vídeos foi postada por usuários comuns (82,95%) e 62,50% estimulavam o consumo do MMS, apesar da maioria (60,23%) não mencionar os riscos de uso. Chama a atenção que 23,64% dos vídeos indicavam local de compra das substâncias que compõem o MMS e que 93,75% dos vídeos publicados após as reportagens eram contra o consumo do produto, apesar da menor popularidade. O uso de mídias sociais como fonte de informação tem sido cada vez mais frequente, apesar da baixa qualidade das informações veiculadas, tornando importante que profissionais de saúde, instituições sanitárias e de ensino se apropriem dessas ferramentas, além dos próprios administradores das redes sociais estabelecerem mecanismos de verificação e exclusão de conteúdos falsos.

Cellular protein–protein interactions are largely dependent on the activities of signaling proteins. Here, we present a technique to tune gene expression at translation level based on G418-inducible readthrough premature termination codon (PTC-on). To demonstrate how this PTC-on can control the expression level of a cellular signaling protein to regulate signal transduction, we settled a p53 PTC-on system in p53-null H1299 cells. After treating with G418, the cells expressed full-length p53 protein in a dose-dependent manner. We further demonstrated to use this PTC-on approach to dissect p53-dependent and p53-independent apoptosis in response to the DNA double strand breaks in H1299 cells. In principle, the PTC-on can be used as a general approach for exploring the functions of any other signaling proteins.

We present a study of the electron magnetohydrodynamics Grad–Shafranov (GS) reconstruction of the electron diffusion region (EDR) of magnetic reconnection. Two-dimensionality of the magnetoplasma configuration and steady state are the two basic assumptions of the GS reconstruction technique, which represent the method’s fundamental limitations. The present study demonstrates that the GS reconstruction can provide physically meaningful results even when these two assumptions, which are hardly fulfilled in spacecraft observations, are violated. This conclusion is supported by the reconstruction of magnetic configurations of two EDRs, encountered by the Magnetospheric Multiscale (MMS) Mission on July 11, 2017 and September 8, 2018. Here, the former event exhibited a violation of two-dimensionality, and the latter event exhibited a violation of steady state. In both cases, despite the deviations from the ideal model configuration, reasonable reconstruction results are obtained by implementing the herein introduced compressible GS reconstruction model. In addition to the discussed fundamental limitations, all existing versions of the GS reconstruction technique rely on a number of minor simplifying assumptions, which restrict the model scope and efficiency. We study the prospects for further model improvement and generalization analytically. Our analysis reveals that nearly all these minor limitations can be overcome by using a polynomial MMS-tailored reconstruction technique in the space of rotationally invariant variables instead of Cartesian coordinates.

On the bow shock in front of Earth’s magnetosphere flows a current due to the curl of the interplanetary magnetic field across the shock. The closure of this current remains uncertain; it is unknown whether the bow shock current closes with the Chapman-Ferraro current system on the magnetopause, along magnetic field lines into the ionosphere, through the magnetosheath, or some combination thereof. We present simultaneous observations from Magnetosphere Multiscale (MMS), AMPERE, and Defense Meteorological Satellite Program (DMSP) during a period of strong By, weakly negative Bz, and very small Bx. This IMF orientation should lead to a bow shock current flowing mostly south to north on the shock. AMPERE shows a current poleward of the Region 1 and Region 2 Birkeland currents flowing into the northern polar cap and out of the south, the correct polarity for bow shock current to be closing along open field lines. A southern Defense Meteorological Satellite Program F18 flyover confirms that this current is poleward of the convection reversal boundary. Additionally, we investigate the bow shock current closure for the above-mentioned solar wind conditions using an MHD simulation of the event. We compare the magnitude of the modeled bow shock current due to the IMF By component to the magnitude of the modeled high-latitude current that corresponds to the real current observed in AMPERE and by Defense Meteorological Satellite Program. In the simulation, the current poleward of the Region 1 currents is about 37% as large as the bow shock Iz in the northern ionosphere and 60% in the south. We conclude that the evidence points to at least a partial closure of the bow shock current through the ionosphere.

In our work, for the first time, we conducted a comprehensive multispacecraft wave study of flapping current sheet oscillations in Earth’s magnetotail. Measurements taken from the Magnetospheric Multiscale (MMS) mission were analyzed for two flapping events with different morphologies of oscillation behavior: stationary-like and kink-like type. A comparison of the results calculated by the methods of phase difference, wave surveyor, and Multipoint Signal Resonator technique was carried out. For the first time, using observations, it was found that the energy distribution of wavy magnetic field contains complex multi-branch dispersion dependencies on ky and kz. The phase velocities of propagation of flapping oscillations were estimated. The used methods complement each other, and their differences made it possible to assess the presence of non-linear wave packets during kink flapping and the azimuthal asymmetry of the current sheet profile.

In this study, we examine particle energization and injections that show energetic electron enhancements at both MMS in the magnetotail and Van Allen Probes in the inner magnetosphere. Observing injections along with a corresponding flow burst allows us to better understand injections overall. Searching for suitable events, we found that only a small number of events at MMS had corresponding injections that penetrated far enough into the inner magnetosphere to observe with Van Allen Probes. With the four suitable events we did find, we compared the energy spectra at the two spacecraft and mapped the boundary of where the injection entered the inner magnetosphere. We found that, among these injections in the inner magnetosphere, the electron flux did not increase above ∼400 keV, similar to previous results, but the corresponding signatures in the tail observed increased fluxes at 600 keV or higher. There does not appear to be a comparable flux increase at Van Allen Probes and MMS for a given event. None of our injections included ion enhancements at Van Allen Probes, but one included an ion injection at geosynchronous orbit in the GOES spacecraft. All of our injections were dispersed at Van Allen Probes, and we were therefore able to map an estimate of the injection boundary. All of the injections occurred in the premidnight sector. Although we found some events where particle energizations in the tail are accompanied by inner magnetospheric injections, we do not find a statistical link between the two.

We took a survey of boundary layer (or low-latitude boundary layer) crossings by the Magnetospheric Multiscale (MMS) mission. Out of 250 total crossings, about half showed enhancements of high-energy (>30 keV) electrons in the FEEPS sensor and a little less than half of those energetic electron events had whistler-mode waves present. Energetic electron enhancements were more likely to be present at magnetic local times closer to noon and at distances of less than about 20 Earth radii, but there was seemingly no correlation with magnetic latitude. For almost all of these events, the pitch angles of the FEEPS electrons were peaked at 90° or isotropic, not field-aligned. Most of the events for which we had data to make a determination showed either direct or indirect evidence of reconnection. Overall, energetic electron enhancements are a fairly common occurrence and there appears to be some connection between whistler waves, energetic electron enhancements, and reconnection, whether it is a direct link or some other process affecting all of them.

Information and Communications Technology (ICT) supports the development of novel control and communication functions for monitoring, operation, and control of power systems. However, the high-level deployment of ICT also increases the risk of cyber intrusions for Supervisory Control And Data Acquisition (SCADA) systems. Attackers can gain access to the protected infrastructures of the grid and launch attacks to manipulate measurements at the substations. The fabricated measurements can mislead the operators in the control center to take undesirable actions. The Intrusion Detection System (IDS) proposed in this paper is deployed in IEC 61850 based substations. The proposed IDS identifies falsified measurements in Manufacturing Messaging Specification (MMS) messages. By cross-checking the consistency of electric circuit relationships at the substation level in a distributed manner, the falsified measurements can be detected and discarded before the malicious packets are sent out of the substations through DNP3 communication. A cyber-physical system testbed is used to validate the performance of the proposed IDS. Using the IEEE 39-bus test system, simulation results demonstrate high accuracy of the proposed substation-based intrusion detection system.

DNA base damage arises frequently in living cells and needs to be removed by base excision repair (BER) to prevent mutagenesis and genome instability. Both the formation and repair of base damage occur in chromatin and are conceivably affected by DNA-binding proteins such as transcription factors (TFs). However, to what extent TF binding affects base damage distribution and BER in cells is unclear. Here, we used a genome-wide damage mapping method, N-methylpurine-sequencing (NMP-seq), and characterized alkylation damage distribution and BER at TF binding sites in yeast cells treated with the alkylating agent methyl methanesulfonate (MMS). Our data show that alkylation damage formation was mainly suppressed at the binding sites of yeast TFs ARS binding factor 1 (Abf1) and rDNA enhancer binding protein 1 (Reb1), but individual hotspots with elevated damage levels were also found. Additionally, Abf1 and Reb1 binding strongly inhibits BER in vivo and in vitro, causing slow repair both within the core motif and its adjacent DNA. Repair of ultraviolet (UV) damage by nucleotide excision repair (NER) was also inhibited by TF binding. Interestingly, TF binding inhibits a larger DNA region for NER relative to BER. The observed effects are caused by the TF–DNA interaction, because damage formation and BER can be restored by depletion of Abf1 or Reb1 protein from the nucleus. Thus, our data reveal that TF binding significantly modulates alkylation base damage formation and inhibits repair by the BER pathway. The interplay between base damage formation and BER may play an important role in affecting mutation frequency in gene regulatory regions.

Mobile laser scanning (MLS) systems mainly comprise laser scanners and mobile mapping platforms. Typical MLS systems are able to acquire three-dimensional point clouds with 1-10 centimeter point spacing at a normal driving or walking speed in the street or indoor environments. The MLS' advantages of efficiency and stability make it a quite practical tool for three-dimensional urban modeling. This paper reviews the latest advances in 3D modeling of the LiDAR-based mobile mapping system (MMS) point cloud, including LiDAR Simultaneous Localization and Mapping (SLAM), point cloud registration, feature extraction, object extraction, semantic segmentation, and deep learning processing. Then typical urban modeling applications based on MMS are also discussed.

Non-uniformity in the response of spectral image elements is an inevitable phenomenon in hyperspectral imaging, which mainly manifests itself as the presence of band noise in the acquired hyperspectral data. This problem is prominent in the infrared band owing to the detector material, operating environment, and other factors. Non-uniformity is an important factor that can affect the quality of the hyperspectral data, which has a serious impact on both data analysis and applications and requires corrections via technical means wherever possible. This paper proposes a novel target-based non-uniformity self-correction method for infrared push-broom hyperspectral images. The Mars Mineralogical Spectrometer (MMS) onboard the Tianwen-1 orbiter was used as the research and application object. The model is constructed and applied to the target scene characteristics and detection patterns of Mars remote sensing exploration, which are combined with the causes of noise generation in the infrared spectral image bands. The design of the MMS dual-channel Visible-Near-Infrared (V-NIR) and Near-Mid-Infrared (N-MIR) co-field of view co-target detection and laboratory calibration data for the V-NIR spectral band can achieve non-uniformity corrections (NUCs). Therefore, for the MMS in-orbit Mars exploration mission, the method selected spectral data (920–1055 nm) characterized by a reduced atmospheric influence to iteratively obtain the homogeneous region, which was used to calculate the non-uniformity correction factor for the N-MIR spectral band. This method was compared, validated, and evaluated with other conventional methods using both laboratory and in-orbit hyperspectral data. The results showed that the experimental data corrections were comparable to laboratory calibrations, with a maximum relative deviation of

Background: Basal cell carcinoma (BCC) is a malignant, slow growing, and locally invasive skin tumor. Advanced and neglected BCC may invade adjacent structures. The 5-year recurrence rates of facial BCCs are 4.1% after excision and 2.5% after Mohs Micrographic Surgery (MMS). The number of BCC cases invading the bones of the head and neck region is limited. Case Illustration: A 75-year-old male complained of bleeding and ulcer enlargement on the right cheek expanding to the right nasal ala for 1 month. The patient had a history of an enlarged and painful lenticular nodule with a hyperpigmented spot that appeared 10 years ago on the right cheek and was diagnosed as BCC. The patient was treated with a wide excision having a negative pathological margin 3 years ago. He noticed that the similar lesion reappeared at the same location 2.5 years ago. Post-operative histopathological results showed nodular infiltrative BCC and maxillary bone invasion. Discussion: Based on history taking, physical examination, and diagnostic evaluation, the diagnosis of the patient was recurrent nodular infiltrative BCC. The final histopathology confirmed that tumor cells invaded the maxillary bone. After considering the treatment options, the patient opted to proceed with radiotherapy. Conclusion: Recurrent nodular BCC with invasion to the maxillary bone is a rare and interesting case. Among 140 BCC cases that we treated with MMS in our hospital from June 2014 to September 2019, this case is the first recurrent BCC with maxillary bone invasion.

Poles and overhead power lines have been common, and maintaining them is necessary. Increasingly, mobile mapping system (MMS) based on integration of various positioning, navigation and imaging data collection sensors is used to maintain the complex structure of power lines. However, MMS algorithms are still a work in progress and most limit measurement environments. Therefore, our purpose is to develop an evaluation method that can handle various challenging scenarios such as complicated configurations, ground slopes on a real world scale.In this paper, we propose a new algorithm for performing efficient extraction and tracking of powerlines from a three-dimensional point cloud data. Our algorithm focuses on the continuity of power lines, and three characteristic properties are used in the algorithm process: Dense point cloud, small color difference, and small light-intensity difference. Experimental results show that proposed method which focuses on the continuity of power lines is effective.

Understanding the nature and characteristics of high-frequency waves inside a flux rope may be important as the wave-particle interaction is important for charged-particle energization and the ensuing dissipation process. We analyze waves generated by an electron beam in a crater-shaped magnetic flux rope observed by MMS spacecraft on the dawnside tailward magnetopause. In this MMS observation, a depression of magnetic field, or a crater, of ∼100 km is located at the center of the magnetic flux rope of ∼650 km. There exist parallel and perpendicular electrostatic wave modes inside the depression of the magnetic field at the center of the flux rope, and they are distinguished by their locations and frequencies. The parallel mode exists at the center of the magnetic depression and its power spectrum peaks below Fce (electron cyclotron frequency). In contrast, the perpendicular mode exists in the outer region associated with the magnetic depression, and its power spectrum peaks near Fce. The linear analysis of kinetic instability using a generalized dispersion solver shows that the parallel mode can be generated by the electron beam of 5,000 km/s. They can thermalize electrons ≲100 eV effectively. However, the generation mechanism of the perpendicular mode is not clear yet, which requires further study.

Stability in time of major and important objectives is vital and can be achieved by 3D scanners which follow changes in time with construction, respective of the natural or artificial hydrotechnical dams and the obtaining of 3D data in real time with the possibility of evaluating and making quick decisions. This scientific paper approaches a research topic of great importance and actuality in the field of Civil Engineering, Hydrotechnics, and Geomatics using the 3D scanning technologies for the hydrotechnical arrangements (Topolovăţu Mic, Coșteiu and Sânmartinu Maghiar) and hydroameliorative (Cruceni Pumping Station). In Romania, data collection was carried out for the first time using the mobile scanning technology (MMS), “Backpack” type, namely, Leica Pegasus Backpack. Data collection using terrestrial laser scanning technology (Terrestrial Laser Scanning) was carried out with the Leica C10 equipment. The processing of point clouds was carried out using the Inertial Explorer program, and the processing of point clouds was carried out with the Cyclone program. The collection of ground checkpoints used for checking, correcting, and analyzing point clouds was carried out using the GPS Leica GS08 equipment. Compared with traditional methods using classical measuring instruments, precise data was obtained (with an error of 2–4 cm) through 3D laser scanning technology in a short time and with multiple possibilities of processing and visualizing point clouds.

This research proposes a detailed analysis of the potential of MMS (Mobile Mapping Systems), supported by SLAM (Simultaneous Localisation And Mapping) algorithms, performed on a multiscale test field in order to make a concrete contribution to the morphological study of cities. These systems, developed with the aim of acquiring a large number of points in a short time, are able to map the surrounding area and automatically localise themselves in real time in relation to a determined reference system. The analysed area, located in Venice, was divided into three different test fields characterised by typical elements potentially comparable to those of other urban realities. The data were acquired using the LiBackPack C50, Kaarta Stencil and Heron Lite systems and compared quantitatively and qualitatively with data obtained from more traditional surveying techniques. Specifically, the data obtained from TLS (Terrestrial Laser Scanning) surveys, supported by topographic measurements, were the most accurate basis on which to evaluate the accuracy and completeness of the three different MMS devices. The standard deviation values were initially analysed in the final 3D global models using the C2C (Cloud to Cloud) and C2M (Cloud to Mesh) distance calculation methods. Subsequently, the geometric differences were investigated through the extraction of horizontal profiles, and two more specific 2D analyses were carried out: the first inspecting the residual parameters calculated after the Helmert transformation from two sets of control points obtained from the profiles, followed by a local strain analysis. The study of the local deformation parameters allowed us to validate the results obtained and to identify the real limits of these survey instruments. The aim was to make a concrete contribution to the formalisation of an operative protocol for the morphological study of the city, exploiting the potential of these technologies to overcome the differences in scale and the gap between outdoor and indoor spaces.

Background: Huntington's disease (HD) is a progressive neurodegenerative disorder. Generally, it is characterized by deficits in cognition, behavior, and movement. Recent studies have shown that pridopidine is a potential and effective drug candidate for the treatment of HD. In the present study, we performed a meta-analysis to evaluate the efficacy and safety of pridopidine in HD.Methods: The MEDLINE, EMBASE, CENTRAL, and Clinicaltrials.gov databases were searched for randomized controlled trials (RCTs) which had that evaluated pridopidine therapy in HD patients.Results: We pooled data from 1,119 patients across four RCTs. Patients in the pridopidine group had a significantly lower Unified Huntington's Disease Rating Scale (UHDRS)-modified Motor Score (mMS) (MD −0.79, 95% CI = −1.46 to −0.11, p = 0.02) than those in the placebo group. Additionally, no differences were observed in the UHDRS-Total Motor Score (TMS) (MD −0.91. 95% CI = −2.03 to 0.21, p = 0.11) or adverse events (RR 1.06, 95% CI = 0.96 to 1.16, p = 0.24) in the pridopidine and placebo groups. In the subgroup analysis, the short-term (≤12 weeks) and long-term (>12 weeks) subgroups exhibited similar efficacy and safety with no statistical significance in TMS, mMS, or adverse events. However, TMS (MD −1.50, 95% CI = −2.87 to −0.12, p = 0.03) and mMS (MD −1.03, 95% CI = −1.87 to −0.19, p = 0.02) were observed to be improved significantly when the dosage of pridopidine ≥90 mg/day. Additionally, pridopidine (≥90 mg/day) increased total adverse events (RR 1.11, 95% CI = 1.00 to 1.22, p = 0.04) compared with placebo. On this basis, we analyzed the incidence of various adverse events when the dosage was ≥90 mg/day. Nonetheless, these results were within the acceptable threshold, although patients developed symptoms, such as nasopharyngitis and insomnia.Conclusion: Pridopidine improved mMS and had no statistical significance in association with TMS or adverse events. Pridopidine (≥90 mg/day) improved TMS and mMS but increased adverse events, such as nasopharyngitis and insomnia. More RCTs were expected to assess pridopidine in HD.

Abstract This article presents 18 magnetic reconnection electron diffusion region (EDR) candidates found using a neural network algorithm with the Magnetospheric Multiscale Mission phase 1a data at the Earth's dayside magnetopause. These new candidates are compared to the 32 previously reported dayside EDRs listed in Webster et al. (2018), https://doi.org/10.1029/2018ja025245, which constitute the training database of our algorithm. One of the main parameters used is a scalar quantity called “MeanRL” which is based on the asymmetry of the electron velocity distribution function and better identifies electron agyrotropy in the plane perpendicular to the magnetic field. In the light of the new EDR candidates found, we discuss and analyze the sign of the energy dissipation during the reconnection process and the distinction between the inner and outer EDRs, with 40% of the candidates showing negative or oscillating dissipation. We also present in details one of the new identified EDR candidates.

The purpose of this study was to determine the chemical composition and to evaluate the genotoxic and antigentoxic activites of the Moroccan Artemisia herba-alba ethanolic extract. The ethanolic extract of Artemisia herba-alba was analyzed by gas chromatography coupled with mass spectroscopy (GC-MS). The mutagenic and antimutagenic activities were evaluated using the somatic mutation and recombination test (SMART) on Drosophila melanogaster. Methyl methanesulfonate (MMS) was used as the positive control.Twenty-one compounds of the Artemisia herba-alba ethanol extract were identified; the main monoterpenes identified are camphor, α-thujone and β-thujone. Ethanolic extract of Artemisia herba-alba did not show gentotoxicity at doses used in SMART Assays. In the co-treatment, a dose-dependent decrease in mutation frequency was observed for this plant. Ethanolic extract of Artemisia herba-alba at 1.5% demonstrated a marked decrease in MMS with a strong inhibitory effect (80%). The results demonstrate that the Artemisia herba-alba exerted a significant and potent anti-mutagenic activity in wing and eye-spot of D. melanogaster.

Lactating Murrah buffaloes (28) were divided into 4 groups of 7 each to study the effect of supplement molasses based multi-nutrient containing chromium picolinate on milk quality and serum biochemistry. Basal diet comprising wheat straw, maize green and concentrate mixture were fed to all the groups. In addition to basal diet, the animals were fed 250 g molasses based multi-nutrient supplement (MMS-1), 5 mg Cr-picolinate and MMS-2 (MMS + 5 mg Cr picolinate) in groups T2, T3 and T4, respectively. Daily milk yield and monthly milk composition were recorded. Blood samples were collected from the jugular vein on days 0, 90 and 180 of experimental feeding for the estimation of serum metabolite profile, concentrations of insulin, non-esterified fatty acid (NEFA), beta-hydroxybutyric acid (BHBA), T3, T4, IGF-1, cortisol, estradiol, progesterone and Cr levels. Results have revealed that the serum Cr concentration increased in Cr supplemented groups; however, the milk Cr concentration was comparable among all the groups. Hematological parameters were statistically comparable among 4 groups except that RBC concentration was higher in group T2. Fat corrected milk (FCM), solid corrected milk (SCM), energy corrected milk (ECM) yields and milk energy contents were significantly higher in MMS supplement groups. Supplementation of MMS and Cr-picolinate had no effect on serum estradiol, NEFA, BHBA, T3, T4, cortisol and IGF-1, however, the concentration of progesterone was significantly lower in all supplemented groups. From the results, it may be deduced that the supplementation of Cr has no adverse effect on FCM yield, however, supplementation of MMS improved FCM yield by 28%. No synergistic effect of supplementation of Cr and MMS on milk composition (fat, protein, SNF, TS and lactose) was observed in lactating Murrah buffaloes.

In the past decades, attempts were made to build a systematic approach to mining method selection (MMS) Ooriad et al., [1]. This is because MMS is a complex and irreversible process. Since it can affect the economic potential of a project, the approach must be as thorough, precise, and accurate as possible. The key challenges of the previously established techniques such as the Nicholas and Laubscher method are that, there was a lack of engineering judgement in the process of selecting a mining method. In other instances, not all the parameters required in the mining method selection process were considered; i.e. economics would be the basis of the final decision of a mining method without taking into consideration other factors such as geology [2]. While other techniques just considered a few parameters and a limited number of mining methods as alternatives (Namin, 2008). Some techniques were customised procedures for a specific orebody [3]. Each orebody is unique; therefore, the approach of just adopting the same mining method for similar commodities was not always an effective or realistic approach Therefore, the existing procedures were found to be inadequate and not applicable for consideration in all MMS processes.To solve the challenges stated above, an up-to-date approach to MMS is the use of multi-criteria decision-making (MCDM) tools to aid in the process. The MCDM are effective in facilitating a decision-making process; however, the use of MCDM has not gained enough popularity across countries and in the mining industry especially in MMS [4]. Their successful implementation in other industries such as in manufacturing companies, water management, quality control, transportation, and product design [5] present an opportunity for further exploration in MMS. In this research, these MCDMs were further explored as starting point to solving the challenge faced in MMS.With the aim of developing a systematic and an unbiased approach that caters for subjective and objective analysis in MMS, this study investigated 10 MCDMs- TOPSIS, TODIM, VIKOR, GRA, PROMETHEE, OCRA, ARAS, COPRAS, SAW, and CP with potential to solve the MMS challenge. The study focused on deriving a model where the MCDMs can be integrated and be successfully used for MMS. Included in the research are factors and mining methods that are necessary in MMS. The aim was to use the factors and mining methods as inputs to the developed MMSM.In the result section, case studies were used to analyse the MCDMs following a descriptive and a statistical analysis (sensitivity analysis, spearman correlation, and Kendall’s coefficient.). PROMETHEE, TOPSIS, and TODIM stood out as methods for use in the selection of mining method in the coal mining industry. From the research findings, it was generally concluded that OCRA, ARAS, CP, SAW, and COPRAS are simplified approaches of the afore-mentioned methods. VIKOR’s rankings were outlying and the conclusion was that it was not a suitable method for MMS. GRA’s conclusion based on the literature view was that there remain many unanswered questions about its mathematical foundations.The MMSM was developed using the results obtained. In the MMSM, first, the user defines the problem. The approach is of case-based reasoning (CBR); where the user can retrieve, re-use, revise and then retain the information (in the database) for future use. The user can always search within the database for a similar problem to select a MCDM, factors and methods; and this may be one of the future areas of improvement on the developed MMSM because there are a number of factors, MCDMs, and mining methods that the user may need to go through before getting to the relevant MCDM. One of the recommendations made by the author was that the user must understand the theoretical background of the MCDM before using it in the MMSM. In future studies, algorithms for selection of a suitable MCDM in the MMSM can be developed so that once the problem has been defined and structured; the user may not struggle with knowing which method to use amongst the suggested. Also, an application-based approach may be investigated further.

Abstract Background Neurofibromatosis type 1 (NF1) is related to a generally increased prevalence of seizures. The mechanism underlying the increased predisposition to seizures has not been fully elucidated. The aim of the study was to evaluate the role of NF1 in seizures pathogenesis in a cohort of children with NF1 and seizures. Methods The medical records of 437 children (0–18 years old) with NF1 were reviewed. All children with at least one afebrile seizure were included. Demographic, clinical, neurological, NF1 mutation status, and EEG data were collected along with brain magnetic resonance imaging. Depending on etiology, structural seizures have been identified and were further classified as NF1 related or not. Results Nineteen patients (4.3%; 13 males) were included. NF1 was inherited in 7 (37.5%), with 3 maternal forms. Ten children with structural seizures were identified. Seven forms were identified someway related to NF1, two of which were associated to 17q11.2 microdeletion and hypoxic-ischemic encephalopathy. Any brain lesion that could explain seizures was found in nine patients, two third of these patients had a familiar history of epilepsy. Conclusions Our results suggest seizures are more frequent in NF1 children (4.3%) than in general pediatric population (0.3–0.5%) and that are someway related to NF1 in half of patients. Facing seizures in NF1, the clinician should first exclude brain tumors but also other, and rarer NF1-related scenarios, such as hydrocephalous and vasculopathies. Children with non-structural seizures frequently had a family history of epilepsy, raising questions about the pathogenic role of NF1. They should be approached as for the general population.

Fructose-1,6-bisphosphatase (FBP1) is a key enzyme in the evolutionary conserved pathway of gluconeogenesis. We had shown in an earlier study that FBP1 is involved in the response and sensitivity to methyl-methanesulfonate (MMS)-induced DNA damage in yeast. In the work presented here we performed an alanine screen mutational analysis of several evolutionary conserved amino acid residues of FBP1, which were selected based on conserved residues and structural studies of mammalian and yeast homologues of FBP1. Mutants were examined for enzymatic activity, and yeast cells expressing these mutants were tested for growth on non-fermentable and MMS-containing media. The results obtained support predicted vital roles of several residues for enzymatic activity and led to the identification of residues indispensable for the MMS-sensitizing effect. Despite an overlap between these two properties, careful analysis revealed two mutations, Asn75 and His324, which decouple the enzymatic activity and the MMS-sensitizing effect, indicating two distinctive biological activities linked in this key gluconeogenesis enzyme.

The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work, we characterize a new temperature-sensitive allele of Schizosaccharomyces pombe mcm4+. Uniquely among known mcm4 alleles, this mutation causes sensitivity to the alkylation damaging agent methyl methanesulfonate (MMS). Even in the absence of treatment or temperature shift, mcm4-c106 cells show increased repair foci of RPA and Rad52, and require the damage checkpoint for viability, indicating genome stress. The mcm4-c106 mutant is synthetically lethal with mutations disrupting fork protection complex (FPC) proteins Swi1 and Swi3. Surprisingly, we found that the deletion of rif1+ suppressed the MMS-sensitive phenotype without affecting temperature sensitivity. Together, these data suggest that mcm4-c106 destabilizes replisome structure.

Background: Adaptive response has been well studied by employing physical and chemical agents in normal test systems, whereas in diseased conditions very little data are available. Aim of the study: To know the presence or absence of adaptive response in diseased condition, alkylating agents such as EMS or MMS have been employed in diabetic mouse. Material and methods: To induce diabetes, mice were injected with 180 mg/kg body weight of Stz. Diabetic mice were treated with conditioning (100 mg/kg body weight of EMS or 40 mg/kg body weight of MMS), challenging (300 mg/kg body weight of EMS or 160 mg/kg body weight of MMS) and combined doses of EMS or MMS with 8 h time lag. Parallelly controls were maintained. Mice were sacrificed at 24 or 48 or 72 h RTs. Bone marrow was extracted and slides were prepared by a routine air dry technique by Evans et al. (1964) to analyze the chromosomal aberrations. Results: The results show that both the alkylating agents induced exclusively chromatid type of aberrations in both diabetic and non diabetic mice, but it is to be underlined that MMS is a more potent inducer of aberrations than EMS. Eventhough, combined treatment of EMS or MMS induced significantly less chromosomal breaks compared to challenging treatment (p

Reactive power management in microgrids with high penetration of distributed renewable energy sources (DRESs) is challenging. The intermittent generation of DRES makes the power management cumbersome. Generally, Flexible AC Transmission System (FACTS) devices such as Distribution Static Compensator (DSTATCOM) are employed for reactive power compensation in microgrids. However, for effective results in microgrids, coordinated operation between DSTATCOM and Distributed Energy Resources (DERs) is required. In this paper, IEC 61850 communication is proposed for realizing coordinated operation between microgrid controller (MGCC), DSTATCOM and DERs. In microgrids, there may be large number of DERs dispersed over a large area. Hence, the underlying communication network technology for IEC 61850 communication must be highly scalable with wide range. Recently developed communication technology Long Term Evolution (LTE) is a promising solution since it offers high data rates, reliability, scalability and longer range. In this paper, the developed IEC 61850 based reactive power management system is tested with the LTE technology and the performance evaluation tests have been performed. Firstly, IEC 61850 messages have been mapped on LTE stack to enable their transmission. Then, simulations over a network emulator have been performed to evaluate the performance of IEC 61850 communication message exchanges over LTE network in terms of End to End (ETE) delays.

This contribution describes the methodology applied to evaluate the suitability of a Long-Range Mobile Mapping System to be integrated with other techniques that are currently used in a large and complex landslide deformation monitoring project carried out in Cortes de Pallás, in Valencia (Spain). Periodical geodetic surveys provide a reference frame realized by 10 pillars and 15 additional check points placed in specific points of interest, all with millimetric accuracy. The combined use of Close-Range Photogrammetry provides a well-controlled 3D model with 1–3 cm accuracy, making the area ideal for testing new technologies. Since some zones of interest are usually obstructed by construction, trees, or lamp posts, a possible solution might be the supplementary use of dynamic scanning instruments with the mobile mapping solution Kaarta Stencil 2 to collect the missing data. However, the reliability of this technology has to be assessed and validated before being integrated into the existing 3D models in the well-controlled area of Cortes de Pallás. The results of the experiment show that the accuracy achieved are compatible with those obtained from Close-Range Photogrammetry and can also be safely used to supplement image-based information for monitoring with 3–8 cm overall accuracy.

In rail transport, measuring the actual condition of a circular curve of a railway track is a key element of track position monitoring not only during operation but also during final works. Predicting changes in its position in the horizontal plane is one of the most important related scientific issues. This paper presents the results of measurements performed with an innovative measuring device called the Magnetic-Measuring Square (MMS). The aim of the research was to demonstrate the acceptability of using the MMS. Horizontal versines of a rail track curve were measured as three neighboring points on a curve (using the method of lacing/stringlining, also called the three-point or the Hallade method), and the perpendicularity of rail joints and shortenings were measured. The MMS device presented in this article was used to measure versines and differences in rails lengths (rail shortenings in the curve) in the operating mode involving a laser distance meter with a laser beam (laser power P < 1 mW, laser wavelength λ = 635 nm) with a target cross, a camera, and a surveying measuring disk. The measurement results confirmed that it is possible to employ the MMS to monitor the geometry of railway track fragments such as track transition curves and railway track curves in rail transport.

Aim: To study the effect of alkylating agents such as EMS and MMS on chromosomes and biochemical parameters in induced diabetic mouse. Methods: Chromosome preparations from bone marrow was made using the method of Evans et al. (1964) and biochemical estimations from the liver was done by the method of Sinha (1972) for catalase, Van der Vies (1954) for glycogen and Uchiyama and Mihara (1978) for MDA. Results: The study has revealed that EMS and MMS induced a dose dependent increase in chromosomal aberrations of chromatid type in the diabetic mouse. Nonetheless, it is interesting to note that, there is significant reduction in the frequency of chromosomal aberrations in diabetic compared to non diabetic mice at all tested doses of EMS or MMS and at different recovery times [RTs]. On the other hand biochemical parameters showed a variable degree of reactivity: (1) catalase activity was significantly elevated in non diabetics whereas in diabetics it is significantly decreased with increasing concentrations of EMS. Contrary to this, the catalase activity in the case of MMS treatment is significantly reduced in non diabetics compared to diabetic mice. (2) However glycogen level is significantly reduced in both the diabetic and non diabetic with increasing concentrations of EMS or MMS, but MDA levels were significantly increased. Conclusion: (1) Even though alkylating agents induce chromosomal aberrations in diabetic mice, MMS, a methylating agent is a more potent inducer of chromatid type of aberrations than EMS, an ethylating agent. (2) Diabetic mouse is more resistant than the non diabetic to alkylating agents and (3) the tested agents altered the analyzed biochemical parameters.

Information hiding techniques, especially steganography, have been extensively researched for over two decades. Nonetheless, steganography on smartphones over cellular carrier networks is yet to be fully explored. Today, smartphones, which are at the epitome of ubiquitous and pervasive computing, make steganography an easily accessible covert communication channel. In this paper, we propose Android-Stego - a framework for steganography employing smart-phones. Android-Stego has been evaluated and confirmed to achieve covert communication over real world cellular service providers' communication networks such as Verizon and Sprint. A key contribution of our research presented in this paper is the benchmark results we have provided by analyzing real world cellular carriers network restrictions on MMS message size. We have also analyzed the actions the carriers take - such as compression and/or format conversion - on MMS messages that fall outside the established MMS communication norm, which varies for each service provider. Finally, We have used these benchmark results in implementing Android-Stego such that it is sensitive to carrier restrictions and robust to message loss.

Spatial information plays a critical role in remote sensing and mapping applications such as environment surveying and disaster monitoring. An Unmanned Aerial Vehicle (UAV)-borne mobile mapping system (MMS) can accomplish rapid spatial information acquisition under limited sky conditions with better mobility and flexibility than other means. This study proposes a long endurance Direct Geo-referencing (DG)-based fixed-wing UAV photogrammetric platform and two DG modules that each use different commercial Micro-Electro Mechanical Systems’ (MEMS) tactical grade Inertial Measurement Units (IMUs). Furthermore, this study develops a novel kinematic calibration method which includes lever arms, boresight angles and camera shutter delay to improve positioning accuracy. The new calibration method is then compared with the traditional calibration approach. The results show that the accuracy of the DG can be significantly improved by flying at a lower altitude using the new higher specification hardware. The new proposed method improves the accuracy of DG by about 20%. The preliminary results show that two-dimensional (2D) horizontal DG positioning accuracy is around 5.8 m at a flight height of 300 m using the newly designed tactical grade integrated Positioning and Orientation System (POS). The positioning accuracy in three-dimensions (3D) is less than 8 m.

DNA methylation is believed to play important roles in regulating gene expression in plant growth and development. Paulownia witches’ broom (PaWB) infection has been reported to be related to gene expression changes in paulownia plantlets. To determine whether DNA methylation is associated with gene expression changes in response to phytoplasma, we investigated variations in genomic DNA sequence and methylation in PaWB plantlets treated with methyl methane sulfonate (MMS) using amplified fragment length polymorphism (AFLP) and methylation-sensitive amplification polymorphism (MSAP) techniques, respectively. The results indicated that PaWB seedings recovered a normal morphology after treatment with more than 15 mg·L−1 MMS. PaWB infection did not cause changes of the paulownia DNA sequence at the AFLP level; However, DNA methylation levels and patterns were altered. Quantitative real-time PCR (qRT-PCR) showed that three of the methylated genes were up-regulated and three were down-regulated in the MMS-treated PaWB plantlets that had regained healthy morphology. These six genes might be involved in transcriptional regulation, plant defense, signal transduction and energy. The possible roles of these genes in PaWB are discussed. The results showed that changes of DNA methylation altered gene expression levels, and that MSAP might help identify genes related to PaWB.

This article proposes the use of a multiscale and multisensor approach to collect and model three-dimensional (3D) data concerning wide and complex areas to obtain a variety of metric information in the same 3D archive, which is based on a single coordinate system. The employment of these 3D georeferenced products is multifaceted and the fusion or integration among different sensors’ data, scales, and resolutions is promising, and it could be useful in the generation of a model that could be defined as a hybrid. The correct geometry, accuracy, radiometry, and weight of the data models are hereby evaluated when comparing integrated processes and results from Terrestrial Laser Scanner (TLS), Mobile Mapping System (MMS), Unmanned Aerial Vehicle (UAV), and terrestrial photogrammetry, while using Total Station (TS) and Global Navigation Satellite System (GNSS) for topographic surveys. The entire analysis underlines the potentiality of the integration and fusion of different solutions and it is a crucial part of the ‘Torino 1911’ project whose main purpose is mapping and virtually reconstructing the 1911 Great Exhibition settled in the Valentino Park in Turin (Italy).

Mobile mapping systems that detect and geo‐reference road markings almost always consist of a stereo camera system integrated with a global positioning system/inertial navigation system. The data acquired by this navigational system allows features detected in the stereo images to be assigned global co‐ordinates. An essential step in this process is the calibration of the cameras, as it relates the pose of the two cameras to each other and a world co‐ordinate system. In Europe, road markings must be evaluated from a 35 m range, so the cameras are required to have a wide field of view. Traditional calibration methods supposedly require a calibration object that would fill most of the calibration images. This large field of view would require a calibration object of substantial size that would be impractical for the purposes of this portable system. This study explores the theory of camera calibration and then details two camera calibration techniques (using portable 3D and 2D calibration objects). The accuracy of these methods is then evaluated using a ground‐truth experiment.

Changes in the mobile phone technology and the rapid increase in the use of mobile phones have created a new field both for marketers and advertisers as well as for researchers to reach consumers. Therefore, marketing applications made through mobile phones have become a subject for various researches. In this study, mobile marketing and advertising have been discussed. This paper investigates the theoretical base in the literature about the relations which display “whether the consumers approve the permitted advertising or not, which types of mobile advertising they adopt, which content specifications of mobile adverts affect them most and what kind of attitudes they develop against mobile adverts, besides that it presents a summary of 44 empirical studies which have been implemented between the years 2000-2011.

Paulownia is a native fast-growing tree in China that has been introduced into many countries. However, it is often infected by Paulownia witches’ broom (PaWB) disease, which can lead to large declines in yield. PaWB is caused by a phytoplasma that is an obligate biotrophic plant pathogen. Until now, the molecular mechanisms of interactions between the host plants and the phytoplasma have not been clear. In previous studies, it was reported that PaWB-infected Paulownia exhibited healthy morphology after being treated with methyl methane sulfonate (MMS) at the concentration of 20 mg·L−1 (for Paulownia tomentosa (PT) and Paulownia fortunei (PF) or 15 mg·L−1 (for P. tomentosa × P. fortunei) MMS. In this study, the whole transcriptome expression profile of PaWB-infected Paulownia was studied using high-throughput sequencing technology. In total, 74 significantly differentially expressed genes were detected among three species of healthy, PaWB-infected Paulownia, and the Paulownia treated with MMS. We identified and analyzed genes related to the roles of phytohormones and alternative splicing events involved in regulating plant growth. In response to phytoplasma infection, the concentrations of the plants’ phytohormones were altered, leading to morphology transformation. This research will provide valuable information to detect the molecular mechanisms involved in the Paulownia response to phytoplasma infection.

Most World Wide Web (WWW) resources are currently accessible from PCs and through HTTP; however, multimodal application research is being carried out and tools and proposals are being developed allowing access to WWW resources from several de-vices and mechanisms. The motivation for developing multimodal and multi-device applications has arisen from organisations’ need to avoid duplicating information and services available in applications and Web pages. This article describes the structure of a tool allowing multimodal and multi-device access to WWW resources through HTTP, SMS, WAP, MMS and S@T. This work’s main contribution lies in its proposing a possible and simple architecture for accomplishing this and validating it through implementing a prototype.

Cashew apple juice (CAJ), produced from the native Brazilian cashew tree (Anacardium occidentale), and has been reported to have antibacterial, antifungal, antitumor, antioxidant and antimutagenic properties. Both the fresh unprocessed juice and the processed juice (cajuína in Portuguese) has been shown to consist of a complex mixture containing high concentrations of anacardic and ascorbic acids plus several carotenoids, phenolic compounds and metals. We assessed both types of juice for their antimutagenic properties against the direct mutagens methyl methanesulfonate (MMS) and 4-nitroquinoline-N-oxide (4-NQO) and the indirect mutagen benzo[a]pyrene (BaP) using pre-treatment, co-treatment and post-treatment assays with Salmonella typhimurium strains TA100, TA102, and TA97a. In pre-treatment experiments with strains TA100 and TA102 the fresh juice showed high antimutagenic activity against MMS but, conversely, co-treatment with both juices enhanced MMS mutagenicity and there was an indication of toxicity in the post-treatment regime. In pre-, co-, and post-treatments with TA97a as test strain, antimutagenic effects were also observed against 4-NQO and BaP. These results suggest that both fresh and processed CAJ can protect the cells against mutagenesis induced by direct and indirect mutagens.

In this article I will elucidate the concept of photo messaging, and examine camera phones in the context of communication and photography. Camera functions are nowadays a popular add-on to the mobile (cellular) phone. Users can send photographs directly from the phone as photo messages. Findings suggest that the ubiquitous camera phone, and photo messaging, may substantially change the ways in which people use personal photography. The imaging capacity of mobile phones is becoming a potential part of perpetual visual contact. Thus taking and sending photographs on a camera phone represents a new resource for visual communication.

Reverse gyrase introduces positive supercoils to circular DNA and is implicated in genome stability maintenance in thermophiles. The extremely thermophilic crenarchaeon Sulfolobus encodes two reverse gyrase proteins, TopR1 (topoisomerase reverse gyrase 1) and TopR2, whose functions in thermophilic life remain to be demonstrated. Here, we investigated the roles of TopR1 in genome stability maintenance in S. islandicus in response to the treatment of methyl methanesulfonate (MMS), a DNA alkylation agent. Lethal MMS treatment induced two successive events: massive chromosomal DNA backbone breakage and subsequent DNA degradation. The former occurred immediately after drug treatment, leading to chromosomal DNA degradation that concurred with TopR1 degradation, followed by chromatin protein degradation and DNA-less cell formation. To gain a further insight into TopR1 function, the expression of the enzyme was reduced in S. islandicus cells using a CRISPR-mediated mRNA interference approach (CRISPRi) in which topR1 mRNAs were targeted for degradation by endogenous III-B CRISPR-Cas systems. We found that the TopR1 level was reduced in the S. islandicus CRISPRi cells and that the cells underwent accelerated genomic DNA degradation during MMS treatment, accompanied by a higher rate of cell death. Taken together, these results indicate that TopR1 probably facilitates genome integrity maintenance by protecting DNA breaks from thermo-degradation in vivo.