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In response to the present epidemic situation, this work proposes an anti-coronavirus composite polymer coating with nano-Ag2MoO4 as the core component to reduce the potential safety hazards caused by excessive use of disinfectants. Nano-β-Ag2MoO4 with mixed morphology was produced with industrialized preparation technology. Among them, oval nanoparticles are core components with antiviral properties, and long rod-shaped particles are used to identify whether the stirring process meets the standard. After x-ray diffraction and field emission scanning electron microscopy testing, nano-β-Ag2MoO4 stored for 4 years still meets the design requirements in terms of purity, crystal phase, shape, and scale, which solves the problem of the long-term effect of core components. In the existing water-based paint production process, the mixing process and formula of nano-β-Ag2MoO4 were explored, and the large-scale production process of anti-virus water-based paint was solved. Resistance tests against the HCoV-229E coronavirus showed that the anti-coronavirus activity rate of the nano-β-Ag2MoO4 coating at a weight concentration of 200 ppm was 99.5% within 2 h, which verified the effectiveness of the composite polymer coating.