51 results on '"Lichen planopilaris"'
Search Results
2. Clinical, Dermoscopic, and Histopathological Analysis of Blaschko-Linear Atrophic Lichen Planopilaris (LPP) of the Face: A Case Series of a Rare Entity
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Aradhana Rout, Ratika Chauhan, and Ashish Kumar Pandey
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blaschkoid ,facial ,lichen planopilaris ,Medicine - Abstract
Blaschko-linear pigmented lesions over the face are encountered rarely, and may either be macular or atrophic. A descriptive clinical, dermoscopic, and histopathological analysis of six such cases of hyperpigmented atrophic lesions in a Blaschko-linear distribution that we saw recently in our outpatient department is presented emphasizing the potential of dermoscopy to facilitate prompt management thereby averting cicatrization.
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- 2024
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3. Oral gabapentin for scalp pruritus in patients with lichen planopilaris: A case series
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Li-Chi Chen, MD, MPH, Chino Ogbutor, BA, Ümmügülsüm Yıldız-Altay, MD, Kristen J. Kelley, BA, and Maryanne M. Senna, MD
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fibrosing alopecia in a pattern distribution ,frontal fibrosing alopecia ,gabapentin ,itch ,lichen planopilaris ,pruritus ,Dermatology ,RL1-803 - Published
- 2024
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4. Multifocal alopecia of the scalp, axillae, and body
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Fabiola Moreno Echevarria, BS, Claudia S. Roldan, BA, Alyce Anderson, MD, PhD, and Jennifer L. Shastry, MD
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alopecia ,Graham-Little-Piccardi-Lasseur syndrome ,lichen planopilaris ,Dermatology ,RL1-803 - Published
- 2024
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5. Assessment and Validity of Trichoscopy for Eyebrow Involvement in Lichen Planopilaris: A Case-Control Study
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Awatef Kelati, Wassim Halli, and Soumiya Chiheb
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Trichoscopy ,Dermoscopy ,Eyebrows ,Hair disorders ,Madarosis ,Lichen planopilaris ,Dermatology ,RL1-803 - Abstract
Introduction: Few publications are available on eyebrow trichoscopy in patients with alopecia areata and frontal fibrosing alopecia (FFA). Objective: We aimed to investigate the validity of using trichoscopy to examine the eyebrow involvement in patients with lichen planopilaris (LPP) and its variants. Methods: In this case control study, 109 patients with eyebrow involvement in LPP and FFA (cases) and with acquired hair disorders of the eyebrows (controls) were included. Results: Trichoscopy was highly specific and sensitive for the diagnosis of LPP and its variants, including FFA. Trichoscopic features significantly associated with LPP were peripilar scaling, peripilar pigmentation, broken hairs, peripilar white halos, diffuse empty follicles, and vellus hair. Localized peripilar erythema and empty follicles were significantly associated with the diffuse form of LPP and zigzag-type FFA. Yellow dots, dystrophic hairs, regrowth in different directions, and diffuse empty follicles were associated with LPP activity and FFA severity. Conclusions: Trichoscopy is a valid tool for evaluating eyebrow involvement in LPP. Thus, it could help increase the diagnostic accuracy and predict the prognosis of eyebrow hair loss at an early stage.
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- 2024
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6. Trichoscopy for Eyelash Involvement in Lichen Planopilaris: A Pilot Prospective Study
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Awatef Kelati, Wassim Halli, and Soumiya Chiheb
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Trichoscopy ,Lichen planopilaris ,Dermoscopy ,eyelashes ,eyebrows ,hair disorders ,Dermatology ,RL1-803 - Published
- 2024
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7. Scalp trauma in lichen planopilaris: Case reports of disease progression from fire fighter helmet use
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Ambika Nohria, BA, Deesha Desai, BS, Camila Ortiz, MD, Shadi Khalil, MD, Ata Moshiri, MD, MPH, Jerry Shapiro, MD, and Kristen Lo Sicco, MD
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fire fighter ,helmet ,lichen planopilaris ,occupational hazard ,scalp trauma ,Dermatology ,RL1-803 - Published
- 2024
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8. Trichoscopic Features of Scalp Discoid Lupus Erythematosus versus Lichen Planopilaris: A Systematic Review
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Gowda SK, Errichetti E, Thakur V, Panda M, Dash S, Agarwal A, Sethy M, Ayyanar P, and Behera B
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scalp discoid lupus erythematosus ,lichen planopilaris ,trichoscopy ,dermoscopy ,primary cicatricial alopecia ,Dermatology ,RL1-803 - Abstract
Shreya K Gowda,1 Enzo Errichetti,2 Vishal Thakur,1 Maitreyee Panda,3 Siddhartha Dash,4 Akash Agarwal,3 Madhusmita Sethy,5 Pavithra Ayyanar,5 Biswanath Behera1 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, OD, India; 2Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy; 3Department of Dermatology, IMS and SUM Hospital, Bhubaneswar, OD, India; 4Department of Dermatology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, OD, India; 5Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, OD, IndiaCorrespondence: Biswanath Behera, Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, 751019, India, Email biswanathbehera61@gmail.comIntroduction: Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are primary scarring alopecias that pose diagnostic challenges clinically, where trichoscopy features may provide benefit in delineating these two cicatricial alopecia, and also helps in assessing the evolution and therapeutic response. To date, there are few reviews on dermoscopic findings in differentiating these two alopecias.Methods: A systematic literature review was conducted using the PubMed and Google Scholar databases. The search terms included for scalp DLE were ‘lupus’ OR ‘discoid lupus’ OR “scalp lupus” and for scalp LPP were “lichen planopilaris” OR “scalp follicular lichen planus” OR “lichen planus follicularis” and were combined with “dermoscopy” OR “dermatoscopy” OR “videodermoscopy” OR “video dermatoscopy” OR “trichoscopy”. The differences in the prevalence of dermoscopic features in scalp DLE and LPP were calculated using the Chi-square test.Results: Of 52 articles, 36 (17 LPP, 19 DLE) were eligible for quantitative analysis. We found predominant peripilar tubular casts and perifollicular erythema with the presence of arborizing vessels in the vicinity of these changes, indicating early LPP. In contrast, follicular red dots, speckled brown pigmentation, and hair diameter variability indicated active DLE. Shiny white areas were common in both the groups in late stages. The target pattern of distribution of blue-grey dots, milky red areas, and irregular white fibrotic dots were seen in LPP, and pink-white background, follicular plugs, perifollicular and interfollicular scale, rosettes, chrysalides, and red spider on yellow dots were detected in DLE. Features such as yellow dots and blue-grey structureless areas were nonspecific and did not have a major role in differentiating DLE from LPP.Conclusion: This article provides a comprehensive review of the literature and delineates the trichoscopic differences and peculiarities of scalp DLE and LPP, including the correlation of dermoscopic features with histopathological findings.Keywords: scalp discoid lupus erythematosus, lichen planopilaris, trichoscopy, dermoscopy, primary cicatricial alopecia
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- 2024
9. Diffuse Lichen Planopilaris Masquerading as Diffuse Alopecia Areata
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Li Jie Helena Yoo, Nekma Meah, Dmitri Wall, and Ian McDonald
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alopecia areata ,lichen planopilaris ,androgenetic alopecia ,Dermatology ,RL1-803 - Abstract
Introduction: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia that represents a form of follicular lichen planus. Case Presentation: We describe a case of coexisting diffuse LPP and female pattern hair loss masquerading as diffuse alopecia areata in a 32-year-old female. Discussion: In complex cases such as this, dermoscopy-guided vertical and horizontal biopsies from androgen sensitive and insensitive areas are helpful in increasing diagnostic yield. Prompt initiation of treatment is key to halting disease progression. Long-term follow-up is important as resolution of clinical signs does not always correlate with the absence of disease progression.
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- 2024
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10. Janus kinase inhibition for the treatment of refractory frontal fibrosing alopecia: A case series and review of the literature
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Charles Dunn, MD, Victoria Griffith, DO, MPH, Alexis Coican, DO, Alexander Dane, DO, William Chow, DO, Savina Aneja, MD, Rajiv Nathoo, MD, Adam Leavitt, MD, and Spencer D. Hawkins, MD
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alopecia ,baricitinib ,frontal fibrosing alopecia ,janus kinase inhibitors ,lichen planopilaris ,ruxolitinib ,Dermatology ,RL1-803 - Published
- 2023
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11. Refractory Folliculitis Decalvans Treatment Success with a Novel Surgical Excision Approach Using Guarded High-Tension Sutures
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Umar S, Waterman A, Ton D, and Shitabata P
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folliculitis decalvans ,treatment ,surgical treatment ,alopecia ,primary cicatricial alopecia ,acne keloidalis nuchae ,lichen planopilaris ,surgery ,therapy ,second intention healing ,tension sutures ,Dermatology ,RL1-803 - Abstract
Sanusi Umar,1– 3 Ade Waterman,3 Donna Ton,3 Paul Shitabata1,2,4 1Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; 2Division of Dermatology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA; 3Dr. U Hair and Skin Clinic, Manhattan Beach, CA, USA; 4Dermatopathology Institute, Torrance, CA, USACorrespondence: Sanusi Umar, Dr. U Hair and Skin Clinic, 2121 N. Sepulveda Avenue, Suite 200, Manhattan Beach, CA, 90266, USA, Tel +1 310 318-1500, Fax +1 310 318-1590, Email drumar@dru.comPurpose: Folliculitis decalvans (FD) is a difficult-to-treat, localized scarring alopecia characterized by an expanding area of chronically inflamed purulent plaques or masses. Current treatment modalities vary and often result in only temporary remission. There are no reports of surgical therapies for FD. Here, we describe FD treatment using surgical excision and second-intention healing aided by guarded high-tension sutures.Methods: Five patients (one woman and four men) with histologically confirmed FD were treated by surgical lesion excision. All wounds were allowed to heal via second-intention. Guarded high-tension sutures were employed to minimize tissue tears while aiding and guiding wound contraction.Results: All wounds healed with a 47– 83% spatial contraction of the maximum wound diameters. Three patients healed entirely by second-intention, while two required a minor skin graft to close the wound completely. No disease recurrence was noted at 10– 24 months.Conclusion: Surgical excision with second-intention healing aided by guarded high-tension sutures effectively treated small and extensive FD lesions with no recurrence at long-term follow-up. To our knowledge, this is the first report of successful surgical treatment of FD.Plain Language Summary: Current treatment modalities of folliculitis decalvans, including steroids, antibiotics, and isotretinoin, are suboptimal, typically resulting in recurrence following the withdrawal of treatments. In this case series, we report a first account of treatment success of refractory folliculitis decalvans using surgical excision with second intention healing aided by guarded high-tension suturing. The outpatient procedure resulted in long-term remission at 10– 24 months follow-up.Keywords: folliculitis decalvans, treatment, surgical treatment, alopecia, primary cicatricial alopecia, acne keloidalis nuchae, lichen planopilaris, surgery, therapy, second intention healing, tension sutures, scaring alopecia, hair loss
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- 2023
12. Unveiling a Shared Precursor Condition for Acne Keloidalis Nuchae and Primary Cicatricial Alopecias
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Umar S, Ton D, Carter MJ, and Shitabata P
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folliculitis decalvans ,lichen planopilaris ,subclinical ,central centrifugal cicatricial alopecia ,frontal fibrosing alopecia ,Dermatology ,RL1-803 - Abstract
Sanusi Umar,1– 3 Donna Ton,3 Marissa J Carter,4 Paul Shitabata1,2,5 1Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; 2Division of Dermatology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA; 3Dr. U Hair and Skin Clinic, Manhattan Beach, CA, USA; 4Strategic Solutions, Inc., Bozeman, MT, USA; 5Dermatopathology Institute, Torrance, CA, USACorrespondence: Sanusi Umar, Dr. U Hair and Skin Clinic, 2121 N. Sepulveda Boulevard, Suite 200, Manhattan Beach, CA, 90266, USA, Tel +1-310-318-1500, Fax +1-310-318-1590, Email drumar@dru.comPurpose: Small observational studies suggest subclinical disease occurrence in the normal-appearing scalp zones of several primary cicatricial alopecias. To aid patient management, we began routinely evaluating the entire scalp of patients with acne keloidalis nuchae (AKN), including trichoscopy-guided biopsies.Patients and Methods: This retrospective study evaluated 41 patients sequentially presenting with AKN at a single clinic between June and December 2022. Primary lesions and normal-appearing scalp in the superior parietal scalp at least 5 cm away from AKN-affected zones were clinically evaluated, and areas showing perifollicular erythema or scales/casts on trichoscopy were biopsied and histologically analyzed.Results: Forty-one men with AKN, including 20 men of African descent, 17 Hispanic, and 4 European-descended Whites, were evaluated. All patients, including 22% with associated folliculitis decalvans, showed scalp-wide trichoscopy signs of perifollicular erythema or scaling in normal-appearing scalp areas. All patients showed histologic evidence of perifollicular infundibulo-isthmic lymphocytoplasmic infiltrates and fibrosis (PIILIF), with 96% showing Vellus or miniaturized hair absence. PIILIF was often clinically mistaken for seborrheic dermatitis (44– 51%). All White patients had mild papular acne keloidalis nuchae lesions mistaken for seborrheic dermatitis.Conclusion: PIILIF may be a precursor to a wide spectrum of primary cicatricial alopecias, including AKN and folliculitis decalvans. This finding carries implications for the early diagnosis and management of AKN and other primary cicatricial alopecias.Plain Language Summary: Acne keloidalis nuchae (AKN) is a type of hair loss and scalp condition marked by scarring and inflammation. This condition falls under a group of chronic hair and scalp issues known as primary cicatricial alopecia (PCA). Current treatments for AKN and similar PCAs often do not work well, and the condition tends to return. We have found a hidden scalp condition that could be causing AKN and other PCAs. It’s a subtle disease that affects the entire scalp, even though it might not show noticeable symptoms. We have observed this condition in all 41 AKN patients in our study, and it’s characterized by certain changes in the hair and scalp’s structure and immune system response. Other studies have linked this condition to various other PCAs. We believe this hidden condition could be causing AKN and making it come back after treatment. This study suggests that treating AKN might require a broader approach beyond just treating the visible symptoms. Since this hidden condition exists in other PCAs, it might be a common cause.Keywords: folliculitis decalvans, lichen planopilaris, subclinical, central centrifugal cicatricial alopecia, frontal fibrosing alopecia, scarring alopecia
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- 2023
13. Correlation of clinical, histopathologic, and direct immunofluorescence findings in lesional and nonlesional scalp of frontal fibrosing alopecia and lichen planopilaris – An observational study
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Isabella Doche, MD, PhD, Neusa Valente, MD, PhD, Mirian N. Sotto, MD, PhD, Maria Cecília Rivitti-Machado, MD, Valéria Aoki, MD, PhD, Paula Gerlero, MD, and Maria K. Hordinsky, MD
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direct immunofluorescence ,frontal fibrosing alopecia ,histopathology ,lichen planopilaris ,scalp biopsy ,scarring alopecias ,Dermatology ,RL1-803 - Published
- 2023
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14. Successful treatment of rare linear lichen planopilaris with Ixekizumab
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Hanof Ahmed, Mahir Petkar, and Martin Steinhoff
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lichen planopilaris ,cicatricial alopecia ,fibrosing alopecia ,targeted therapy ,anti-interleukin-17 ,ixekizumab ,Dermatology ,RL1-803 - Abstract
Background: Lichen planopilaris (LPP) is a lymphocytic primary cicatricial alopecia characterized by perifollicular erythema, follicular hyperkeratosis and scaring, resulting in permanent hair loss. Current treatment modalities, both topical and systemic, fail to achieve satisfactory and consistent results. As therapies fail to halt the inflammatory process, patients with LPP may face long-term disfigurement and significant psychological burden. Purpose: To initiate an efficacious targeted therapy with good tolerability and low side effect profile that will allow hair regrowth and prevent the development to disfiguring alopecia. Materials and methods: Here, we report on a case of rare LPP in a linear distribution (LLPP) involving the scalp and forehead failing to achieve satisfactory results with continued hair loss with multiple previous treatments. Results: Complete hair regrowth was achieved 12 weeks after treatment with an anti-psoriatic, anti-interleukin (IL)-17A/F antibody (Taltz, Ixekizumab, Lilly). Patient continued to display sustained efficacy with no reported side effects until 12 months on treatment. Conclusions: The present case underlines the viability of Ixekizumab as a possible first-line, targeted therapy for LPP and its variants with sustained efficacy. Multicenter trials are warranted to confirm the benefit of Ixekizumab as a successful targeted biologic treatment option for LPP and LLPP.
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- 2023
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15. Efficacy and Safety of Combination 308-nm Excimer Laser and Intralesional Corticosteroid versus Intralesional Corticosteroid Monotherapy in the Treatment of Frontal Fibrosing Alopecia: A Pilot Study
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Rattapon Thuangtong, Supisara Wongdama, Nuttagarn Jantanapornchai, Chadakan Yan, Kanchalit Thanomkitti, and Daranporn Triwongwaranat
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excimer laser ,intralesional corticosteroid ,frontal fibrosing alopecia ,lichen planopilaris ,Medicine - Abstract
Frontal fibrosing alopecia (FFA) is a slowly progressive cicatricial alopecia that can result in permanent hair loss, so early diagnosis and treatment is crucial. However and of concern, a standard treatment regimen for FFA has not yet been established. In an attempt to remedy this gap, we conducted this study to investigate the efficacy and safety of combined 308-nm excimer laser with intralesional corticosteroid (ILC) compared to ILC alone to treat FFA. The results of our study revealed that the combination of 308-nm excimer laser and ILC was not superior to ILC alone for treating FFA. Moreover, side effects, including erythema and postinflammatory hyperpigmentation, were reported in both groups.
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- 2023
16. Folliculitis Decalvans With Frontal Fibrosing Alopecia in a Dark Phototype: Presentation of Folliculitis Decalvans and Lichen Planopilaris Phenotypic Spectrum
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Basma Karrakchou, Amani Fliti, Amal El Fiboumi, Fouad Kettani, Karima Senouci, and Mariame Meziane
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folliculitis decalvans ,frontal fibrosing alopecia ,lichen planopilaris ,phenotypic spectrum ,Dermatology ,RL1-803 - Published
- 2023
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17. Estudio de la expresión de receptores de andrógenos, estrógenos y progesterona mediante inmunohistoquímica en pacientes con alopecia frontal fibrosante
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Néstor Carreño-Orellana, Daniela Alfaro-Sepúlveda, María Paz Traipe, and Verónica Vial-Letelier
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Alopecia ,Alopecia Cicatrisata ,Lichen Planopilaris ,Androgens ,5-alpha Reductase Inhibitors. ,Medicine - Abstract
Resumen: Introducción: La alopecia frontal fibrosante (AFF) es una alopecia linfocítica primaria cicatricial, cuya patogenia se desconoce. Se han desarrollado distintos regímenes de tratamientos farmacológicos, siendo el finasteride por sí sólo o en combinación con corticoides, un tratamiento efectivo. Objetivo: Evaluar si en pacientes con AFF la expresión de receptores de andrógenos en las células del folículo piloso es diferente en comparación a los controles sanos. Métodos: Se confeccionaron micromatrices de biopsias de cuero cabelludo de muestras seleccionadas de pacientes con diagnóstico clínico de AFF e histopatológico de AFF/líquen plano pilaris; y muestras de cuero cabelludo sano con características epidemiológicas similares a la de los pacientes seleccionados. Se realizó un estudio inmunohistoquímico para evaluar la expresión de receptores de andrógenos, estrógenos y progesterona en todas las muestras Resultados: Se incluyeron 27 pacientes con AFF diagnosticada clínica e histológicamente, y 26 controles. El 48% de los pacientes con AFF presentaba receptores de andrógenos en cuero cabelludo, en comparación con un 27% de los pacientes sin AFF, diferencias estadísticamente no significativas (valor p >0,05). Los receptores de estrógenos y progesterona fueron negativos en todas las muestras de casos y controles. Conclusión: Existe una tendencia a que los pacientes con AFF presenten una mayor expresión de receptores de andrógenos que pacientes sanos. Se requieren estudios con diseños prospectivos y mayores tamaños muestrales para validar estos resultados, los que además podrían evaluar la correlación entre la presencia de receptores de andrógenos y la respuesta a tratamiento antiandrogénico. Abstract: Introduction: Frontal fibrosing alopecia (FFA) is a lymphocytic primary cicatricial alopecia, which etiology is unknown. Multiple pharmacological therapies have been developed, being finasteride alone or in combination with corticosteroids an effective treatment. Objectives: To evaluate if the expression of androgen, progesterone and estrogen receptors in the hair follicle of patients with FFA differs from healthy controls. Methods: Microarrays were constructed from scalp biopsies taken from patients with a clinical diagnosis of FFA, and histopathological diagnosis of FFA/lichen planopilaris; and from healthy scalp samples from patients with similar demographic characteristics to those of the case group. Immunohistochemical staining was performed to determine the expression of androgen, estrogen and progesterone receptors in all samples. Results: This study included 27 patients with clinical and biopsy-proven FFA and 26 controls. 48% of scalp samples from patients with FFA presented androgen receptors, in contrast to 27% of samples from patients without FFA, although this difference was not statistically significant (p value >0.05). Estrogen and progesterone receptors were negative in all samples. Discussion: There is a tendency for patients with FFA to have a higher concentration of androgen receptors than healthy patients. Studies with prospective designs and larger sample sizes are required to validate these results, which could also evaluate the correlation between the presence of androgen receptors and the response to antiandrogen treatment.
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- 2023
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18. The spectrum of fibrosing alopecias
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Gloria Orlando, Bianca M. Piraccini, and Michela Starace
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fibrosing alopecia pattern distribution ,frontal fibrosing alopecia ,lichen planopilaris ,lichen planopilaris diffuse pattern ,lichenoid alopecias ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia considered the most common cause of scarring hair loss in adults. It has been classified into three clinical variants: classical LPP, frontal fibrosing alopecia (FFA) and Graham Little‐Piccardi‐Lassueur syndrome. Classical LPP usually presents as a circumscribed cicatricial patch on the vertex and FFA as a band‐like scarring alopecia of the frontotemporal hairline. Fibrosing alopecia in a pattern distribution (FAPD) and lichen planopilaris diffuse pattern (LPPDP) are two recently described subtypes of LPP that exhibit a diffuse involvement of the androgen‐dependent region or the whole scalp, respectively. Classical LPP, FFA, FAPD and LPPDP share trichoscopic (cicatricial areas, absence of follicular openings, perifollicular erythema and hyperkeratosis) and histologic features (interface dermatitis involving follicular epithelium and concentric fibrosing around the isthmus and infundibulum). The remarkable clinical and histological overlap between these entities has led to the concept that these diseases exist along a spectrum. In the effort to identify classical LPP, FFA, FAPD and LPPDP with an umbrella term, we suggest to use ‘lichenoid alopecias’, as the distinguishing hallmark of these diseases is the lichenoid bandlike inflammatory infiltrate in the superficial dermis involving the infundibulum and isthmus of the hair follicle.
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- 2022
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19. Basal cell carcinoma arising within an alopecic patch of lichen planopilaris
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Blake W. Boudreaux, MD, Aaron R. Mangold, MD, Steven A. Nelson, MD, and Shari A. Ochoa, MD
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basal cell carcinoma ,carcinogenesis ,corticosteroids ,lichen planopilaris ,lichen planus ,malignant ,Dermatology ,RL1-803 - Published
- 2022
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20. Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss
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Ncoza C. Dlova, MBChB, PhD, Tarryn Jacobs, MBChB, and Satish Singh, MBChB
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alopecia ,alopecia treatment ,cardiopulmonary side effects ,frontal fibrosing alopecia ,hair loss ,lichen planopilaris ,Dermatology ,RL1-803 - Published
- 2022
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21. Familial Graham-Little-Picardi-Lassueur syndrome across 3 generations
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Diego Soto-García, MD, Carlos Feal-Cortizas, MD, Carlos Álvarez, MD, Carmen Couselo-Rodríguez, MD, Sandra Martínez-Fernández, MD, and Ángeles Flórez, PhD
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familial Graham-Little-Piccardi-Lassueur syndrome ,lichen planopilaris ,scarring alopecia ,Dermatology ,RL1-803 - Published
- 2022
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22. Histopathological Diagnosis of Alopecia Clinically Relevant to Alopecia Areata
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Chinmanat Lekhavat, Pinyo Rattanaumpawan, Antonella Tosti, Tarinee Korviriyakamol, Suthep Jerasutat, Poonnawis Sudtikoonaseth, and Penvadee Pattanaprichakul
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Alopecia areata ,scarring alopecia ,lichen planopilaris ,lupus erythematosus panniculitis ,hair disorders ,histopathology ,Medicine - Abstract
Objective: To study the histopathological diagnosis of alopecia clinically relevant to AA and to compare the histopathology between acute and chronic AA divided by time to onset at three and six months. Materials & Methods: We conducted a cross-sectional study of 113 patients with typical manifestation of AA. Two scalp biopsies were done horizontally and vertically to confirm diagnosis. Histological findings of AA in the acute group were subsequently compared with the chronic group. Results: Of the 113 eligible patients, 109 (96.5%) were pathologically diagnosed with AA. Other diagnoses included lichen planopilaris, lupus panniculitis, and unspecified scarring alopecia. The percentage of terminal telogen hairs in the acute group was significantly higher than the chronic group (mean % anagen: % telogen ratio = 21.2%:78.8% vs. 36.0%:64.0%; p = 0.016), while the chronic group had a significantly higher number of follicular streamers (mean ± SD; 2.5 ± 2.2 vs. 3.7 ± 2.6; p = 0.023). The number of vellus hairs significantly increased in the acute group at the six-month onset (p = 0.006). The number of nanogen hairs also increased significantly in the chronic group at both the three- and six-month onset (p = 0.020 and p = 0.007). Conclusion: Typical manifestations of AA are not always diagnosed as AA. Acute AA has more terminal telogens and vellus hairs, while chronic AA has more follicular streamers and nanogen hairs.
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- 2023
23. Platelet-rich plasma in alopecia areata and primary cicatricial alopecias: A systematic review
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Kasama Tejapira, Tanat Yongpisarn, Nawara Sakpuwadol, and Poonkiat Suchonwanit
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AA ,immune-mediated alopecia ,lichen planopilaris ,LPP ,non-scarring alopecia ,PCA ,Medicine (General) ,R5-920 - Abstract
BackgroundImmune-mediated alopecias (IMAs), a group of hair disorders associated with immunological reactions, remain a therapeutic challenge since available treatments are generally unfavorable with potential side effects. Platelet-rich plasma (PRP) has been recently proposed as a treatment option based on several limited-quality studies; however, there is no systematic evaluation of PRP efficacy on IMAs in the literature.ObjectiveTo assess PRP’s effects in treating IMAs using a systematic review.MethodsElectronic searches were conducted using PubMed, Embase, Scopus, and Cochrane Library databases. A search strategy was designed to retrieve all studies exploring PRP in treating IMAs, including alopecia areata (AA) and primary cicatricial alopecias (PCAs). In addition, all randomized and non-randomized studies reporting subjective and/or objective outcomes of alopecia treatment with PRP were included.ResultsThirty-two studies were included, comprising 621 patients with AA and 19 patients with PCAs. PRP had superior efficacy as monotherapy in five studies, comparable to intralesional corticosteroids in six studies in AA treatment. In addition, in the analysis of PCAs, including lymphocytic and neutrophilic subtypes, PRP was efficacious in alleviating disease progression in nine studies.ConclusionPRP is considered a promising treatment for AA and PCAs in patients who experienced unfavorable outcomes from conventional treatment. However, its clinical application remains to be standardized, and its recommendation as a treatment for IMAs could not be ascertained due to a lack of high-quality evidence.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=353859], identifier [CRD42022353859].
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- 2022
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24. Differential diagnosis distinction of nummular headache and Lichen planopilaris
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Filipović-Danić Snežana, Mitrović Vekoslav, Milošević Nenad, and Stevanović Aleksandar
- Subjects
nummular headache ,lichen planopilaris ,Medicine - Abstract
Introduction: Nummular headache is a type of primary headache of chronic character, with a large number of described varieties in the clinical picture, and therefore the differential diagnostic consideration must include a large number of disorders related to changes in epicranial structures. Certain dermatological disorders can also include pain in a limited area of the scalp with itching, burning or burning sensation, such as Lichen Planopilaris. Case report: This is a report of a patient who was initially diagnosed with Lichen planopilaris, but after determining the parameters of the distinction and the necessary additional diagnostic procedures, a diagnosis of Nummular headache was made. Conclusion: In this presentation, we have presented another important differential diagnostic item and we believe that the work is a small contribution to everyday practice, but also to further research.
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- 2022
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25. Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases
- Author
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Marcos Carmona-Rodríguez, Fernando Moro-Bolado, Guillermo Romero-Aguilera, Ricardo Ruiz-Villaverde, and Víctor Carriel
- Subjects
trichology ,frontal fibrosing alopecia ,lichen planopilaris ,hair loss ,alopecia ,erythema ,Science - Abstract
(1) Background: Frontal fibrosing alopecia (FFA) is a scarring alopecia that predominantly affects postmenopausal women; (2) Methods: A retrospective, observational, single-center study was conducted in the Hospital General Universitario in Ciudad Real, Spain, including all patients diagnosed with FFA between 2010 and 2021; (3) Results: A total of 306 patients (296 women and 10 men) were included in our study. The mean age of onset was 59.5 years. The severity of this disease was evenly distributed between mild (147 patients) and severe (149 patients) forms. There was a positive, statistically significant, medium correlation between the severity of the disease and its time of progression. Moreover, hypothyroidism was present in 70 patients (22.9%) and classic signs of concomitant lichen planopilaris were observed in just 30 patients (9.8%), while other forms of lichen planus were uncommon. The estimated prevalence in our population is 0.15% and the incidence is 15.47 new cases per 100,000 inhabitants; (4) Conclusions: The time of progression was positively correlated with the severity of FFA. However, the presence of clinical signs, such as inflammatory trichoscopic signs, was not associated with the progression of this condition.
- Published
- 2023
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26. Optimal Management of Frontal Fibrosing Alopecia: A Practical Guide
- Author
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Imhof R and Tolkachjov SN
- Subjects
alopecia ,frontal fibrosing alopecia ,hair loss ,scarring alopecia ,treatment ,management ,hair ,inflammatory hair disorder ,lichen planopilaris ,primary lymphocytic cicatricial alopecia ,scarring ,Dermatology ,RL1-803 - Abstract
Reese Imhof,1 Stanislav N Tolkachjov2 1Mayo Clinic Alix School of Medicine, Rochester, MN, USA; 2Epiphany Dermatology, Dallas, TX, USACorrespondence: Stanislav N Tolkachjov Email stan.tolkachjov@gmail.comAbstract: Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia that is often considered a clinical variant of lichen planopilaris (LPP) due to their shared histopathologic features. FFA is characterized by the recession of the frontal, temporal, or frontotemporal hairline; the clinical pattern is distinct and usually includes eyebrow hair loss, as well as other associated symptoms. Pruritus, facial papules, eyelash loss, body hair involvement, and trichodynia may also occur in addition to the frontotemporal recession and eyebrow loss classically seen. Early diagnosis and prompt treatment are critical as FFA is a progressive disorder that can result in permanent hair loss. FFA is challenging as patients may not present or be recognized until the disease has progressed. Additionally, there is currently no consensus or standard treatment regimen for FFA. While many different therapies have been reported as beneficial, there are a limited number of published guidelines for the treatment of FFA. This article is a review of the literature on treatment modalities for FFA and the objective is to offer a practical guide for clinicians on the evidence-based management options currently available in the literature.Keywords: alopecia, frontal fibrosing alopecia, hair loss, scarring alopecia, treatment, management, hair, inflammatory hair disorder, lichen planopilaris, primary lymphocytic cicatricial alopecia, scarring
- Published
- 2020
27. Isotretinoin for the treatment of facial lichen planopilaris: A new indication for an old drug, a case series study
- Author
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Farahnaz Fatemi, Fatemeh Mohaghegh, Farzaneh Danesh, Mina saber, and Parvin Rajabi
- Subjects
frontal fibrosing alopecia ,Lichen planopilaris ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Despite the little information about the facial papules due to Lichen planopilaris (LPP), we have many cases with facial skin roughness in which histological study has showed LPP. Additionally, in those patients treating for frontal fibrosing alopecia or scalp LPP there was no improvement in facial papules.
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- 2020
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28. Quality of life and mental health status in patients with lichen planopilaris based on Dermatology Life Quality Index and General Health Questionnaire-28 questionnaires
- Author
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Maryam Nasimi, MD, MSC, Narges Ahangari, MD, Vahide Lajevardi, MD, Hamidreza Mahmoudi, MD, Seyedeh Zahra Ghodsi, MD, and Ifa Etesami, MD, MPH
- Subjects
Lichen planopilaris ,Quality of life ,Dermatology Life Quality Index (DLQI) questionnaire ,General Health Questionnaire-28 (GHQ-28) ,Dermatology ,RL1-803 - Abstract
Background: Lichen planopilaris (LPP) is a relatively uncommon inflammatory skin condition that causes permanent hair loss. Irreversible hair loss can have a significant psychosocial and psychological impact on patients’ lives. Limited studies have assessed the psychological status of patients suffering from LPP, and to our knowledge, none have evaluated patients with LPP as a separate group in this regard. Objective: This study aimed to assess the quality of life (QoL) and general health of patients with LPP using the Dermatology Life Quality Index (DLQI) questionnaire and General Health Questionnaire-28 (GHQ-28), respectively. Methods: Our study employed a cross-sectional design. In total, 41 patients with LPP attending the follow-up skin clinic at the Razi Hospital in Tehran, Iran were asked to complete the DLQI and GHQ-28. Furthermore, selected demographic information was obtained from patients to evaluate their association with general health and QoL. Results: Forty-one patients (14 men and 27 women) with a mean age of 44.02 ± 10.8 years completed both questionnaires. QoL was affected moderately to extremely in 70.7% of patients. Also, 26 patients (63.4%) were at risk for psychological disorders. Lower QoL was reported by patients age
- Published
- 2020
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29. Graham-Little-Piccardi-Lassueur Syndrome: Two Case Reports and Review of the Literature
- Author
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Dourmishev L., Mironova N., Popov I., Rusinova D., Balabanova M., and Miteva L.
- Subjects
lichen planopilaris ,cicatricial alopecia ,graham-little-piccardi-lassueur syndrome ,Medicine - Abstract
Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare syndrome characterized by the triad of cicatricial alopecia of the scalp, non-cicatricial alopecia of the axilla and groin and follicular lichen planus eruptions on the trunk and extremities. GLPLS is considered to be a variant of lichen planopilaris. We report two cases that have fulfilled all of the criteria for GLPLS. The first case was a 71-year-old woman, admitted to the Department of Dermatology for pruritic perifollicullar erythema and scaling of the scalp, cicatricial scalp alopecia and hair loss of the axilla and pubic region for five months. Subsequently, follicular hyperkeratotic eruptions and hyperpigmented macules on the skin of the chest and abdomen appeared. The second case was a 48-year-old man with pruritic follicular papules on the face, trunk and extremities for four months. All of the laboratory examinations in both patients were within normal limits. No alternation in the general condition of the patients was observed. Histological examinations in both patients confirmed the diagnosis GLPLS. The patients were treated with systemic and local corticosteroid resulting in marked improvement of the skin lesions; however, cicatricial scalp alopecia showed no response to the treatment.
- Published
- 2020
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30. The simultaneous occurrence of lichen planopilaris and alopecia areata: A report of two cases and literature review
- Author
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Fatemeh Mohaghegh, Bahareh Bahrami, and Mina Saber
- Subjects
alopecia ,alopecia areata ,lichen planopilaris ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Although the coexistence of alopecia areata and lichen planopilaris is rare, if alopecic patches appear abruptly, this possible association should be kept in mind.
- Published
- 2020
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31. Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration
- Author
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Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai, and Sung-Jan Lin
- Subjects
Hair follicle stem cell ,Niche ,Function ,Alopecia ,Alopecia areata ,Lichen planopilaris ,Medicine - Abstract
Abstract Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality that enables stem cells to detect these changes and to communicate with remote cells/tissues to tailor their activity for organismal needs. The cyclic growth of hair follicles is powered by hair follicle stem cells (HFSCs). Using HFSCs as a model, we categorize niche cells into 3 functional modules, including signaling, sensing and message-relaying. Signaling modules, such as dermal papilla cells, immune cells and adipocytes, regulate HFSC activity through short-range cell-cell contact or paracrine effects. Macrophages capacitate the HFSC niche to sense tissue injury and mechanical cues and adipocytes seem to modulate HFSC activity in response to systemic nutritional states. Sympathetic nerves implement the message-relaying function by transmitting external light signals through an ipRGC-SCN-sympathetic circuit to facilitate hair regeneration. Hair growth can be disrupted by niche pathology, e.g. dysfunction of dermal papilla cells in androgenetic alopecia and influx of auto-reacting T cells in alopecia areata and lichen planopilaris. Understanding the functions and pathological changes of the HFSC niche can provide new insight for the treatment of hair loss.
- Published
- 2020
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- View/download PDF
32. Graham-Little-Piccardi-Lassueur Syndrome With Concomitant Mucocutaneous Lichen Planus: Rare Presentation in a Man
- Author
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Avita Dhiman, Priyanka Sangwan, Neirita Hazarika, and Prashant Durgapal
- Subjects
alopecia ,cicatricial ,lichen planopilaris ,male ,non-cicatricial ,Dermatology ,RL1-803 - Published
- 2022
- Full Text
- View/download PDF
33. Vitamin D deficiency among patients with lichen planopilaris or frontal fibrosing alopecia
- Author
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Shaheir Ali, BA, Maya Collins, BS, Isabel Pupo Wiss, BA, and Maryanne Senna, MD
- Subjects
frontal fibrosing alopecia ,hair loss ,lichen planopilaris ,scarring alopecia ,vitamin D ,Dermatology ,RL1-803 - Published
- 2022
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- View/download PDF
34. Prevalence of lichen planopilaris in the United States: A cross-sectional study of the All of Us research program
- Author
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Tejas P. Joshi, BS, Harrison Zhu, BSA, Zain Naqvi, BS, Swathi Holla, MS, Anthony Duruewuru, BS, and Vicky Ren, MD
- Subjects
epidemiology ,hair loss ,lichen planus ,lichen planopilaris ,prevalence ,Dermatology ,RL1-803 - Published
- 2022
- Full Text
- View/download PDF
35. Psoriasiform lichen planopilaris: Unusual variant or coincidence
- Author
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Eingun James Song, MD, Audrey Jia Shin Wong, BS, and John Zhang, MD, PhD
- Subjects
apremilast ,cyclosporine ,lichen planopilaris ,methotrexate ,psoriasis ,risankizumab ,Dermatology ,RL1-803 - Published
- 2021
- Full Text
- View/download PDF
36. Graham‐Little Piccardi Lassueur syndrome and review of the literature
- Author
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Fares A. Alkhayal, Fahad Alsudairy, luluah alMubarak, and Hind M. Almohanna
- Subjects
Graham‐Little Piccardi Lassueur syndrome ,Lichen planopilaris ,lichen planus ,scaring alopecia ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Graham‐Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of lichen planopilaris (LPP) which characterized by triad of fibrosing alopecia of the scalp, non‐fibrosing alopecia of the axilla and groin, and a follicular spinous papule over the body. LPP is a rare follicular subtype of lichen planus which causes scarring alopecia of scalp, and there are three clinical subtypes of LPP including classic lichen planopilaris, frontal fibrosing alopecia, and GLPLS. Herein, we describe an adult dark‐skinned Saudi male with GLPLS who has numerous body follicular papules, complete loss of axillary hair, and partial loss of groin hair in addition to patchy fibrosing alopecia of the scalp. To the best of our knowledge, this is the first reported case of GLPLS in Saudi Arabia.
- Published
- 2021
- Full Text
- View/download PDF
37. Treatment of lichen planopilaris with adalimumab in a patient with hidradenitis suppurativa and rheumatoid arthritis
- Author
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Maryam Shayesteh Alam, MD, FRCPC, FAAD and Brittanie LaBelle, MD
- Subjects
adalimumab ,frontal fibrosing alopecia ,hair regrowth ,hidradenitis suppurativa ,lichen planopilaris ,rheumatoid arthritis ,Dermatology ,RL1-803 - Published
- 2020
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- View/download PDF
38. A rare case of lichen planus follicularis tumidus involving bilateral retroauricular areas
- Author
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Vaishali H Wankhade, Pranita P Daware, Bhagyashree Babanrao Supekar, and Rajesh Pratap Singh
- Subjects
lichen planopilaris ,lichen planus follicularis tumidus ,milia en plaque ,Dermatology ,RL1-803 - Abstract
Lichen planus follicularis tumidus (LPFT) is an extremely rare variant of lichen planus characterized by white to yellow milia-like cysts and comedones on a violaceous to hyperpigmented plaque most commonly involving retroauricular area. Clinically, it resembles milia en plaque. It is usually asymptomatic, more common in middle-aged females. Histopathologically, it has features of lichen planopilaris along with follicular cysts in dermis surrounded by lichenoid infiltrate. We are reporting a case of LPFT in a 62-year-old male patient involving bilateral retroauricular areas due to the rarity of this condition.
- Published
- 2020
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39. Lichen Planopilaris developing at the margins of a sebaceous nevus of jadassohn: Co-existence or etiologic association?
- Author
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Alexander C Katoulis, Despina Mortaki, Dimitrios Sgouros, Aikaterini I Liakou, Evangelia Bozi, Dimitra Koumaki, Korina Tzima, and Ioannis Panayiotides
- Subjects
alopecia ,dermoscopy ,epidermal nevus ,lichen planopilaris ,pathogenesis ,sebaceous nevus ,Dermatology ,RL1-803 - Abstract
Sebaceous nevus (SN), is a skin hamartoma, combining a variety of epidermal, follicular, sebaceous, and apocrine abnormalities. Although usually present at birth, it may become apparent later in life appearing as a yellowish-brown, verrucous plaque with alopecia. SN is implicated with secondary tumors arising on the hairless plaque during the adulthood. Lichen planopilaris is a common, primary lymphocytic scarring alopecia of unknown etiology, characterized by lichenoid/interface perifollicular lymphocytic infiltrate occurring at the level of the infundibulum and the isthmus. Here, we present a case of a 48-year-old Caucasian male with lichen planopilaris lesions developing at the periphery of a preexisting SN. Our case raises the question, whether the development of lichen planopilaris was coincidental, or is it indicative of an etiologic association between the lichen planopilaris and SN.
- Published
- 2020
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40. Uncommon presentation of lichen planopilaris during paclitaxel chemotherapy: Case report
- Author
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Nwanneka M Okwundu, Felicia E Ekpo, Jessica Ghafferi, and David Fivenson
- Subjects
alopecia ,cicatricial ,folliculotropic mycosis fungoides ,frontal fibrosing alopecia ,lichen planopilaris ,lichen planus ,systemic lupus erythematosus ,Dermatology ,RL1-803 - Abstract
Lichen planopilaris (LPP) is an uncommon scalp disorder of unknown etiology and prevalence. It may be an autoimmune process triggered by unknown genetic and/or environmental factors that attack hair follicles of the scalp. LPP can present in association with various autoimmune diseases and immunomodulatory therapies. We present an atypical case of LPP occurring during the treatment of breast cancer with paclitaxel, after complete resolution of alopecia areata and anagen effluvium. Shortly after initiation of the paclitaxel therapy, the patient experienced a pruritic acneiform facial eruption and hair loss that was localized to her frontal scalp with complete loss of eyebrows and significant loss of her eyelashes. The lesions were biopsied revealing LPP. LPP should be considered among other causes of alopecia in patients treated with paclitaxel.
- Published
- 2020
- Full Text
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41. Fibrosing Alopecia in a Pattern Distribution: A Case Report and Literature Review
- Author
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Korn Triyangkulsri, Ploychompoo Srisuwanwattana, Tueboon Sriphojanart, and Poonkiat Suchonwanit
- Subjects
alopecia ,cicatricial alopecia ,lichen planopilaris ,pattern hair loss ,scarring alopecia ,Dermatology ,RL1-803 - Abstract
Fibrosing alopecia in a pattern distribution (FAPD) is a relatively new entity in the family of cicatricial alopecia. It has been categorized as a member of the lichen planopilaris (LPP) group due to its similarity in clinical and histopathological presentation. Nonetheless, the disease earns its own entity due to its lichenoid inflammation exclusively involving miniaturized hair and area of involvement mimicking pattern hair loss which differentiates itself from other types of LPP or pattern hair loss. Since its first introduction by Zinkernagel and Trüeb in 2000, there have been only few case reports and series of FAPD. We herein report a case of FAPD in a postmenopausal woman who had progressive hair loss over the course of 10 years.
- Published
- 2019
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42. Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review
- Author
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Behnoush Bakhshoudeh, Maryam Salehi, Ramin Sadeghi, Alireza Omranzadeh, Toktam Sahranavard, Soheil Arekhi, Ali Jafarzadeh Esfehani, and Naghmeh Zabolinejad
- Subjects
frontal fibrosing alopecia ,lichen planopilaris ,treatment ,Medicine (General) ,R5-920 - Abstract
Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion.
- Published
- 2018
- Full Text
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43. Therapeutic management of classic lichen planopilaris: a systematic review
- Author
-
Errichetti E, Figini M, Croatto M, and Stinco G
- Subjects
Lichen planopilaris ,management ,therapy ,treatment. ,Dermatology ,RL1-803 - Abstract
Enzo Errichetti, Matteo Figini, Margherita Croatto, Giuseppe Stinco Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy Abstract: Several treatment strategies have been proposed in classic lichen planopilaris (LPP), although no gold standard therapeutic approach has been recognized so far due to the variable and, sometimes, contradictory results reported in the literature, as well as due to the lack of guidelines and randomized controlled trials. In the present review, we sought to provide an updated overview on the treatment of classic LPP by analyzing the level of evidence of published studies, also proposing a possible therapeutic strategy according to the findings highlighted in this systematic review. Keywords: lichen planopilaris, management, therapy, treatment
- Published
- 2018
44. Frontal fibrosing alopecia preceding the development of vitiligo: A case report
- Author
-
Brianna De Souza, MD, Laura Burns, BS, and Maryanne Makredes Senna, MD
- Subjects
frontal fibrosing alopecia ,lichen planopilaris ,pigment disorders ,scarring alopecia ,vitiligo ,Dermatology ,RL1-803 - Published
- 2020
- Full Text
- View/download PDF
45. Lichen planopilaris associated with pembrolizumab in a patient with metastatic melanoma
- Author
-
Anna L. Cogen, MD, PhD, Vishwas Parekh, MD, Tara Gangadhar, MD, and Jules B. Lipoff, MD
- Subjects
lichen planopilaris ,lichenoid eruptions ,medication side effects ,pembrolizumab ,programmed cell death-1 inhibitors ,Dermatology ,RL1-803 - Published
- 2018
- Full Text
- View/download PDF
46. A Case of Secondary Osteoma Cutis Associated with Lichen Planopilaris
- Author
-
Gloria Orlando, Roberto Salmaso, and Stefano Piaserico
- Subjects
osteoma cutis ,multiple miliary osteomas ,scalp ,lichen planopilaris ,scarring alopecia ,ossifying disorder ,osseous metaplasia ,Dermatology ,RL1-803 - Abstract
Abstract is missing (Short communication)
- Published
- 2019
- Full Text
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47. Incidental Syringomas of the Scalp in a Patient with Scarring Alopecia
- Author
-
Kristyn Deen, Claudia Curchin, and Jason Wu
- Subjects
Syringoma ,Scalp ,Alopecia ,Lichen planopilaris ,Dermatology ,RL1-803 - Abstract
Syringomas are benign adnexal neoplasms of eccrine lineage, which occur most commonly in the periorbital region in middle-aged females. These cutaneous lesions rarely occur on the scalp, are typically asymptomatic and are predominantly of cosmetic significance. Involvement of the scalp may be indistinguishable from that of scarring alopecia. We present an unusual case of clinically inapparent syringomas occurring on the scalp of a 56-year-old female with alopecia who was subsequently diagnosed with lichen planopilaris after repeated scalp biopsy. In patients with unexplained hair loss, or in cases that are refractive to treatment, clinicians should perform scalp biopsy to exclude the diagnosis of rare neoplastic lesions like syringomas and to diagnose associated conditions.
- Published
- 2015
- Full Text
- View/download PDF
48. Severe plaque psoriasis with coexisting cicatricial alopecia treated with adalimumab – case report
- Author
-
Dorota Krasowska, Michał Adamczyk, Małgorzata Michalska-Jakubus, and Aldona Pietrzak
- Subjects
psoriasis ,lichen planopilaris ,biologic agents ,TNF-α inhibitors ,Medicine ,Dermatology ,RL1-803 - Abstract
Introduction. Tumor necrosis factor α (TNF-α) inhibitors are used in the management of many immune-mediated diseases, including the treatment of severe plaque psoriasis. Lichen planopilaris is an inflammatory dermatosis, which typically affects women at the perimenopausal age and is a cause of progressive cicatricial alopecia. It is stated that TNF-α plays an important role in the pathogenesis of both psoriasis and lichen planopilaris, in which it is responsible for apoptosis of basement layer keratinocytes. There are few reports in the literature concerning lichen planopilaris observed during treatment of psoriasis and psoriatic arthritis with TNF-α antagonists. Objective. To present and discuss the case of a patient with severe plaque psoriasis with coexisting scarring alopecia treated with adalimumab. Case report . A 54-year-old female patient with a few-year history of hair loss was treated with adalimumab for severe plaque psoriasis. During biologic therapy almost complete remission of psoriatic lesions was observed, but in the scalp area diffuse scarring alopecia with hyperkeratotic perifollicular papules was seen, with no features of inflammation. On the basis of clinical appearance and histopathological examination a diagnosis of lichen planopilaris was established. A topical treatment was applied with good results. Conclusions . In the presented case the therapy with TNF-α antagonist was effective in the treatment of psoriasis. Probably, it also inhibited active lesions of lichen planopilaris.
- Published
- 2014
- Full Text
- View/download PDF
49. Frontal Fibrosing Alopecia: Role of Dermoscopy in Differential Diagnosis
- Author
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P. Rubegni, F. Mandato, and M. Fimiani
- Subjects
Alopecia ,Dermoscopy ,Menopausal ,Lichen planopilaris ,Dermatology ,RL1-803 - Abstract
Frontal fibrosing alopecia (FFA) is more common in postmenopausal women, but it can occur in younger women. Some authors consider FFA to be a distinct frontal variant of lichen planopilaris. From a clinical point of view, this relatively uncommon condition is characterized by progressive frontotemporal recession due to inflammatory destruction of hair follicles. Dermoscopy can be very useful, as the differential diagnosis between traction alopecia, alopecia areata, FFA and cicatricial marginal alopecia may be difficult. It is not clear whether or not treatment alters the natural history of the disease – the disease stabilized with time in most of the patients with or without continuing treatment. Here we report a case of a 50-year-old woman with FFA and discuss the relevance of dermoscopy in the differential diagnosis of this disease.
- Published
- 2010
- Full Text
- View/download PDF
50. Clinical efficacy and safety of methotrexate versus hydroxychloroquine in preventing lichen planopilaris progress: A randomized clinical trial
- Author
-
Farahnaz Fatemi Naeini, Mina Saber, Ali Asilian, and Sayed Mohsen Hosseini
- Subjects
Hydroxychloroquine ,lichen planopilaris ,methotrexate ,Medicine - Abstract
Background: Lichen planopilaris is an inflammatory cicatricial alopecia, and its management is a challenge for dermatologists. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris. Methods: In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate/week or 200 mg hydroxychloroquine twice a day for 6 months. Side effects, symptoms/signs, and laboratory tests were assessed periodically. Lichen Planopilaris Activity Index (LPPAI) was measured before intervention and at 2, 4, and 6 months after. The changes from baseline to the end of the study were analyzed within each group and between the two groups by per-protocol and intention-to-treat analysis. Results: After 2 months, mean (standard deviation [SD]) decrease in LPPAI in methotrexate group was significantly more than that in hydroxychloroquine group (1.68 [1.24] vs. 0.8 [0.71], respectively,P = 0.047). Furthermore, after 6 months, mean (SD) decrease in LPPAI in methotrexate group was significantly higher than that in hydroxychloroquine group (3.3 [2.09] vs. 1.51 [0.91], respectively,P = 0.01). The following symptoms/signs showed significant improvements in frequency and/or severity in methotrexate group after intervention: pruritus (P = 0.007), erythema (P = 0.01), perifollicular erythema (P = 0.01), perifollicular scaling (P = 0.08), spreading (P = 0.001), and follicular keratosis (P = 0.04). In hydroxychloroquine group, only erythema (P = 0.004) showed significant improvement. Conclusions: Methotrexate was more effective than hydroxychloroquine in treating refractory lichen planopilaris.
- Published
- 2017
- Full Text
- View/download PDF
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