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Introduction and objective: In all societies, with the increase of age bone mass also decreases. Osteoporosis is a common disease among middle-age and older persons, especially women. Therefore, the necessity of implementing strategic plans to prevent osteoporosis is significantly important. This study was designed to determine the prediction of osteoporosis preventive behaviors through the use of the Health Belief Model (HBM). Methods: This cross-sectional study was done among 402 women in Mashhad in 2014. A multi-stage cluster sampling was used. In order to gather collection a questionnaire consistent with the structures of HBM and IPAQ and FFQ was used. Data were analyzed using the SPSS16 and descriptive analysis (frequency, percentage, mean ± SD) and analysis (correlation coefficient, regression and Linear regression). The significance level was 0.5. Results: The mean age of the participants were 36.5 ± 8.1 years. Average monthly calcium intake was 14703.1 ± 8377.5 mg 63.7% of the people with lower physical activity were among inactive groups. Construct barriers perceived (p = 0.008) had a significant impact on the feeding behavior of calcium intake. Self- efficacy (p> 0.001) had a significant impact on physical activity behavior. Conclusion: The results showed that the HBM to predict well for osteoporosis preventive behaviors in women. Its use in training programs will be effective. Type of Article: Research paper.