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Abstract The Antarctic krill Euphausia superba is a key species in Antarctic waters, mainly because it is a major component of the diet of dominant predators, including penguins. It is also a marine living resource that is commercially harvested. Since 2000, krill fishing has become more concentrated. On the basis of several years of data, it has been reported that up to 57% of the krill fishery harvests occur in the Bransfield Strait area. The distribution of krill in the Southern Ocean is not well described. Studies that compare the size of krill caught by commercial vessels with that recorded in the diet of predators are even rarer. The main objectives of this study were to assess the spatial diversity in the size and putative age of krill in the CCAMLR subarea 48.1, to investigate the spatial availability of krill and its size and age structure, and to assess whether the diet of Pygoscelis penguins reflects the size structure of krill present in the environment. The results implied that the size and age structure of the krill population were similar throughout the Bransfield Strait during the study period, although those in the eastern and southern parts of the strait and the Brabant Island region were the most similar. The Livingston Island and Drake Passage areas were clearly distinguishable from the above regions, where larger and therefore older krill were recorded. All Pygoscelis penguin species showed size preferences for consumed krill; therefore, their diet is likely not a reliable indicator of the size of krill in the environment. Krill that had not yet reached sexual maturity, and thus not yet started reproducing were commercially caught in the Bransfield Strait during the investigated years.

The objective of the study was to determine the feasibility of plastic forming by hot rolling of the AA2519 aluminium alloy sheets and cladding these sheets with a layer of the EN AW-1050A alloy. Numerous hot-rolling tests were carried out on the slab ingots to define the parameters of the AA2519 alloy rolling process. It has been established that rolling of the AA2519 alloy should be carried out in the temperature range of 400-440°C. Depending on the required final thickness of the sheet metal, appropriate thickness of the EN AW-1050A alloy sheet, used as a cladding layer, was selected. As a next step, structure and mechanical properties of the resulting AA2519 alloy sheets clad with EN AW-1050A alloy was examined. The thickness of the coating layer was established at 0,3÷0,5mm. Studies covered alloy grain size and the core alloy-cladding material bond strength.

The aim of the study was to test and assess products extruded from the magnesium alloys type MgAlZn: AZ31, AZ61 and AZ80A alloys in the form of Ø35mm round bars and 80x15mm flat bars. The test material was extruded in a direct system with the ram feed speed of 1 mm/s and the extrusion ratio λ = 7 ÷ 9. The extruded bars were examined in as-extruded state and after heat treatment to the T5 temper and T6 temper. The strength properties were tested and microstructure was examined with calculation of the average grain size.

Contemporary materials engineering requires the use of materials characterised by high mechanical properties, as these precisely properties determine the choice of material for parts of machinery and equipment. Owing to these properties it is possible to reduce the weight and, consequently, the consumption of both material and energy. Trying to meet these expectations, the designers are increasingly looking for solutions in the application of magnesium alloys as materials offering a very beneficial strength-to-weight ratio. However, besides alloying elements, the properties are to a great extent shaped by the solidification conditions and related structure. The process of structure formation depends on the choice of casting method forced by the specific properties of casting or by the specific intended use of final product. The article presents a comparison of AZ91 magnesium alloys processed by different casting technologies. A short characteristic was offered for materials processed by the traditional semi-continuous casting process, which uses the solidification rates comprised in a range of 5 - 20°C/s, and for materials made in the process of Rapid Solidification, where the solidification rate can reach 106 °C/s. As a result of the casting process, a feedstock in the form of billets and thin strips was obtained and was subjected next to the process of plastic forming. The article presents the results of structural analysis of the final product. The mechanical properties of the ø7 mm extruded rods were also evaluated and compared.

Objectives The aim of this work is to initiate or revive a scientific discussion on the impact of professional life on the parameters of human lifespan. Material and Methods Presented analysis is based on 8578 Polish elite or well-known person who died in 2001–2021. Results The results of the conducted analysis indicate that in the case of men the highest values of the median age at death were characteristic of freelancers (median [Me] ± quartile deviation [QD] 85.5±8.5 years), followed by scientists and academic teachers of the biological and medical specialty (Me±QD 84.0±7.5 years) and officers of power structures (Me±QD 83.5±8.5 years). Subsequently, the highest value of the median age at death was recorded for social activists (Me±QD 83.0±9.5 years), clergy (Me±QD 82.0±7.5 years) and scientists and academic teachers of specialties other than biological and medical (Me±QD 82.0±8.0 years). Significantly, at the very end of this list are athletes (Me±QD 77.0±9.0 years). Nevertheless, the results of the analysis confirm that professional athletes are characterized by higher median age at death compared to the general population. Analysis made only within athletes group demonstrated that the parameters of lifespan of athletes of endurance disciplines (Me±QD 78.0±8.0 years) are the most favorable compared to athletes of other disciplines, in particular in compare to team sports athletes (Me±QD 75.0±10.0 years) or combat sports athletes (Me±QD 75.0±7.1 years). Conclusions What is new and innovative in this paper is comparing the lifespan characteristics of athletes in comparison to widely represented group of other professions with higher socio-economic status. Unexpectedly, the lifespan of athletes occurred to be lower than for fast all other analyzed occupational groups, except mainly of entertainment musicians. Finally, the results presented in this paper emphasize the need to analyze the lifespan characteristics of athletes in a broader scope than only in relation to the general population. Int J Occup Med Environ Health 2024;37(3):335–50

Enterobacterales (especially carbapenem-resistant) are considered an urgent threat to public health. The available antibiotic therapy is limited due to the increase of multidrug-resistant (MDR) strains. Tigecycline, a minocycline derivative, has emerged as a potential key agent in the treatment of MDR isolates. The aim of the study was to evaluate the synergistic effect of tigecycline in combination with nine antimicrobial agents—ceftazidime/avibactam, colistin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem/vaborbactam, polymyxin B, and rifampicin. Eighty clinical Enterobacter cloacae strains were obtained from patients of two University Hospitals in Bialystok, Poland. The E-test method was used to determine synergistic interactions. Among all combinations, synergy was reported in 61% of cases, addition in 32%, and indifference in 7%. The highest synergy rates were observed in tigecycline combinations with: ceftazidime/avibactam (60/80; 75%), imipenem (60/80; 75%), polymyxin B (55/80; 68.75%) and rifampicin (55/80; 68.75%), while the lowest synergy rate was noted in tigecycline-levofloxacin (26/80; 32.5%). The tigecycline-gentamicin showed the highest rate of indifference; antagonism, was not observed in any combination. In conclusion, tigecycline appears more suitable for use in combination therapy rather than as monotherapy and can be effectively paired with various antimicrobial agents against MDR E. cloacae. Further research will be necessary to confirm these results.

Abstract The global climate change is mainly caused by carbon dioxide (CO2) emissions. To help reduce CO2 emissions and conserve thermal energy, sustainable materials based on flexible thermal insulation are developed to minimize heat flux, drawing inspiration from natural systems such as polar bear hairs. The unique structure of hollow double‐shell fibers makes it possible to achieve low thermal conductivity in the material while retaining exceptional elasticity, allowing it to adapt to insulation systems of any shape. The layered system of porous mats reaches a thermal conductivity coefficient of 0.031 W∙m⁻¹∙K⁻¹ and enables to reduce the heat transfer. The results achieved using scanning thermal microscopy (SThM) correlate with the simulated heat flow in the case of individual fibers. This research study brings new insights into the energy efficiency of domestic environments, thereby addressing the growing demand for sustainable and high‐performance insulation materials for saving energy loss and reducing pollution footprint.

Objectives: To describe the clinical and longitudinal patterns of presentation, and to understand the underlying socioeconomic characteristics of different modes of presentation. Design: Retrospective state-wide data linkage analysis of emergency department (ED) presentations. Patients were included if they were 18 years of age or over and presented to the ED over twenty times within any consecutive 365-day period between January 2015 and December 2020. This analysis used routinely collected data from the Emergency Department Data Collection and Admitted Patient Data Collection. The quintile of Socioeconomic Indexes for Area (SEIFA) defined by Australian Bureau of Statistics was used for equity considerations. Main outcome measures: The main outcomes of interest included patients’ clinical presentation, demographic information and SEIFA score as represented by Index of Relative Socioeconomic Advantage and Disadvantage (IRSAD) quintiles. Results: There were 417,154 presentations and 5,244 patients who met the inclusion criteria. The majority of the presentations were from SEIFA groups 1 (28.2 %) and 2 (35.6 %). The most common presentations were for drug and alcohol (17.5 %), followed by abdominal pathology (11.8 %) and mental health (11.5 %). In the lowest SEIFA group, the main presenting complaints were for drug and alcohol and administrative presentations. While in the highest SEIFA group, the main presentations were for mental health then abdominal pain, followed by drug and alcohol presentations. Conclusion: Patients in the lower SEIFA groups tended to be older with lower acuity presentations and were more likely to present to the same facility, more regularly. Patients in the lower SEIFA group were also more likely to present with drug and alcohol and administrative presentations while those in the higher SEIFA groups were more likely to present with mental health presentations. System wide interventions are needed to address the needs of both groups, particularly those from lower socioeconomic backgrounds, who would benefit from improved access to primary care either through access to General Practice or Urgent Care Centres.

This paper presents a new type of underactuated ground mobile robot called Caster Car. The platform consists of a front-driven and steered wheel and two uncontrolled rear caster wheels. The Caster Car model presented can be an interesting alternative for mobile robots that connects dynamic properties of hovercrafts and classical 4-wheeled cars. Underactuated properties of the Caster Car cause that classical proportional-derivative feedback control give the ability to affect only selected configuration variables. Three mathematical models of the Caster Car are proposed: a dynamic model with free-moving casters, a dynamic model with blocked casters, and a simplified hovercraft description. Models were tested during tracking tasks with demanding trajectory using selective and full-state control. This full state control was based on the computed torque technique with the pseudoinverse operation and proportional-derivative feedback. It gives the ability to suppress unstable behaviors of uncontrolled orientation but in cost of overall effect (higher position errors).

The purpose of this study was to evaluate the effect of genistein in nano, micro, and macro forms on the intensity of the DMBA-induced tumor process in rats and to understand the mechanisms of this action. The effect of genistein supplementation on the content of selected eicosanoids (HETEs, HODE, and HEPE) in the serum of rats was evaluated. The levels and expression of genes encoding various pro-inflammatory cytokines (IL-1, IL-6) and MMP-9 in the blood of rats were also investigated. The biological material for the study was blood obtained from female rats of the Sprague Dawley strain (n = 32). The animals were randomly divided into four groups: animals without supplementation, and animals supplemented at a dose of 0.2 mg/kg b.w. (0.1 mg/mL) with macro, micro (587 ± 83 nm), or nano (92 ± 41 nm) genistein. To induce mammary neoplasia (adenocarcinoma), rats were given 7,12-dimethyl-1,2-benz[a]anthracene (DMBA). The content of selected eicosanoids was determined by liquid chromatography with UV detection. An immunoenzymatic method was used to determine the content of cytokines and MMP-9. The expression of the IL-6, IL-1beta, and MMP-9 genes was determined with quantitative real-time PCR (qRT-PCR) using TaqMan probes. Based on the study, it was shown that supplementation of animals with genistein in macro, micro, and nano forms increased the intensity of the tumor process in rats. It was shown that the content of 12-HEPE, HODE, and 12-HETE in the serum of genistein-supplemented rats was statistically significantly lower with respect to the content of the aforementioned markers in the serum of rats receiving only a standard diet, devoid of supplementation. It was found that animals supplemented with nano-, micro-, and macrogenistein had higher levels of metalloproteinase-9, MMP-9, compared to animals without supplementation. There was a significant increase in MMP-9 gene expression in the blood of macrogenistein-supplemented animals, relative to the other groups of rats. On the basis of the study, it was shown that supplementation of animals with nano-, micro-, and macrogenistein had an effect on the development of the tumor process. Dietary supplementation with genistein significantly decreased the level of selected eicosanoids, which may have significant impacts on cancer development and progression.

Introduction: Apart from pharmacological treatment, non-pharmacological strategies including physical activity play a significant role in the management of asthma. The aim of this paper is to examine various topics related to swimming and asthma. They include the detailed effect of swimming on asthma control,the potential role of swimming in early childhood asthma development, exercise induced asthma in swimmers as well as the relationship between asthma and cold water swimming. Review methods: This article is based on the literature found in the PubMed Database from the period of 1971-2024 with the use of keywords such as “asthma”, “swimming”, “cold water swimming”, “exercise induced asthma”, “childhood asthma” Description of the state of knowledge: Swimming is a safe form of physical activity for asthma patients.Swimming training enhances aerobic capacity, reduces exercise-induced bronchoconstriction and improves lung function in both pediatric and adult patients. However, there is a concern regarding indoor swimming pools that chlorine can potentially induce airway inflammation. There is research suggesting that early life swimming pool exposure may contribute to the asthma development in atopic children. There is some premise to the thought that cold water swimming may help alleviate asthma symptoms, but it also carries many risks.Swimming is a major cause of exercise induced asthma in professional athletes. Conclusions: Alongside appropriate pharmacological treatment, swimming is a valuable strategy in asthma management in both pediatric and adult asthma patients. The risks of chlorinating pools are still not known to outweigh the benefits of swimming for asthmatics. Further research should be carried out on safety of early swimming in atopic children. Cold water swimming should also be evaluated in terms of safety and potential benefits for asthma patients.

Introduction: Eating disorders are potentially mortal health conditions affecting mostly young people. The reasons for that in general population are connected to vulnerable self-image, following the current beauty standards and co-existing psychiatric comorbidities. Athletes may be in danger of developing a pathological eating pattern due to sport specific reasons such as higher scores related to thinner body. Aim of study: The main aim of the study was to examine the relationship between eating disorders in professional athletes’ population, evaluate causes and risk factors and to assess health consequences to eating disorder in sport. Materials and methods: This article is based on the literature found in PubMed and Google Scholar Database with the use of keywords such as ”eating disorders”, “sport”, “athletes”, “anorexia nervosa in athletes”, “eating disorders in sport”, “disordered eating in sportsmen”, “female athletes”, “bulimia nervosa”, “binge eating”, “ED and sport”, “mental health and sport”, “consequences of eating disorders”, “sport education”. Results: Investigation of available literature revealed the connection between developing eating disorder in professional athlete sample. The reasons behind it are mostly sports’ oriented and connected to the desire to achieve better results and perfectionism. However, developing an eating disorder results in worse sports’ performance, menstrual irregularity, lower bone mineral density, cardiovascular issues and can be potentially mortal. Conclusion: Athletes are in danger of developing eating disorders. There should be a focus on evaluating people in sport in terms of eating patterns, however available questionnaires are inefficient because players tend to underreport their problems. Coaches and families of the athletes need to be educated in the topic as they can recognize dangerous behaviors first.

Given global water scarcity and the quest for sustainable energy, there's a pressing need for integrated approaches addressing water‐energy interdependence worldwide. A practical approach for this challenge involves the implementation of fog water collectors. Herein, a polyvinylidene fluoride (PVDF) multifunctional device capable of harvesting water and electricity from wind is developed and tested, collecting up to 365 mg cm−2 h−1 of fog water. Due to the piezoelectric nature of electrospun PVDF, these yarns and meshes not only serve as piezoelectric sensors, enabling the detection of incoming fog flow and determination of its speed and, bust also harvest electricity by charging a capacitor, making it a green and renewable power source. In this study, promising insights are offered into developing efficient fog water collection methods and utilizing piezoelectric fiber‐based yarns and meshes for multifunctional applications in sustainable water management, energy harvesting, and sensing in a single device.

Introduction and purpose: Polyunsaturated fatty acids (PUFAs) are a well-known component of a nutritionally balanced diet. There is a wealth of evidence demonstrating that the ingestion of these substances enhances health, as they are involved in a multitude of metabolic processes that are essential for cellular functionality. However, the contemporary Western diet is distinguished by a reduction in the consumption of omega-3 polyunsaturated fatty acids (PUFAs). The objective of this review is to present the potential therapeutic efficacy of omega-3 PUFA supplementation in the most common inflammatory skin disorders, such as acne vulgaris, atopic dermatitis and psoriasis vulgaris. State of knowledge: Acne vulgaris, atopic dermatitis and psoriasis vulgaris differ in terms of their pathophysiology. However, they are all characterised by underlying inflammatory processes. Omega-3 fatty acids have been demonstrated to possess anti-inflammatory properties. They are capable of modulating both the innate and the adaptive immune responses, thereby alleviating the symptoms of the aforementioned skin disorders. Summary: Given the pluripotent anti-inflammatory qualities of omega-3 polyunsaturated fatty acids, it is reasonable to conclude that they have the potential to become an effective therapeutic tool in the management of inflammatory skin diseases.

Introduction: Chronotype reflects an individual's preference for activity and rest within a 24-hour period, governed by the internal circadian clock system located in the suprachiasmatic nuclei of the hypothalamus. There are three chronotypes: Morning, Evening, and Intermediate. The evening type is also called “night owls” or late chronotype. Night owls prefer to be active in the evening and sleep and wake up late. The misalignment between the sleep patterns in late chronotype and the social schedules puts the night owls in danger of physical and mental health issues. Purpose of work: The primary aim of this review is to provide a comprehensive overview of current knowledge on the impact of late chronotype on health. Methods and materials: A review of the literature available in the PubMed database, the following keywords and their combinations were searched: "chronotype", “mental health", "cancer", “late chronotype”, “circadian rhythm”, “type 2 diabetes”, “depression”. State of knowledge: Studies have confirmed that late chronotype is associated with a higher risk of type 2 diabetes, obesity, cancer, alcohol and cigarette addiction, and unhealthy eating habits. Furthermore, the evening chronotype is an independent risk factor for depression. It is also linked with anxiety, bipolar disorder, and schizophrenia. Summary: In this review, we have summarized the latest research on late chronotype, circadian misalignment, and their potential consequences on human health. Most studies on evening chronotype and related health issues are cross-sectional. Further longitudinal or experimental research is needed to examine the potential cause-and-effect relationships on this cause.

Introduction and purpose: Nutrition plays an important role in the lives of young athletes. A well-balanced diet is crucial not only for their sports performance, but also for their proper growth and optimal health. The aim of this study is to evaluate the dietary intake of the School of Sports Championship students. A brief description of the state of knowledge: When compared to the nutritional needs of regular teenagers, young athletes have higher caloric requirements. They need to follow precise meal scheduling, must maintain proper hydration, and sometimes need to use dietary supplements. Moreover, adolescent athletes, especially females, have a higher risk of athlete triad, anemia, or eating disorders. In addition, young athletes seem to be unaware of the importance of their diet and how it directly affects their overall health and athletic performance. Conclusions: The results of this study indicate that the dietary choices of young athletes significantly affect their sports performance. We found a correlations between the duration of trainings and the intake of sequentially: protein, fiber, and vitamin D. Also, we discovered that female athletes consume less vitamin D and iron compared to male athletes, which may lead to a dangerous health implications, including anemia or the female athlete triad. However, there is a need for more prospective randomized clinical trials conducted on a larger sample size to reach final conclusions.

Abstract Background Children and their families often face obstacles in accessing mental health (MH) services. The purpose of this study was to develop and pilot test an electronic matching process to match children with virtual MH resources and increase access to treatment for children and their families during COVID-19. Methods Within a large observational child cohort, a random sample of 292 families with children ages 6–12 years were invited to participate. Latent profile analysis indicated five MH profiles using parent-reported symptom scores from validated depression, anxiety, hyperactivity, and inattention measures: (1) Average Symptoms, (2) Low Symptoms, (3) High Symptoms, (4) Internalizing, and (5) Externalizing. Children were matched with virtual MH resources according to their profile; parents received surveys at Time 1 (matching process explanation), Time 2 (match delivery) and Time 3 (resource uptake). Data on demographics, parent MH history, and process interest were collected. Results 128/292 families (44%) completed surveys at Time 1, 80/128 families (63%) at Time 2, and a final 67/80 families (84%) at Time 3, yielding an overall uptake of 67/292 (23%). Families of European-descent and those with children assigned to the Low Symptoms profile were most likely to express interest in the process. No other factors were associated with continued interest or uptake of the electronic matching process. Most participating parents were satisfied with the process. Conclusions The electronic matching process delivered virtual MH resources to families in a time-efficient manner. Further research examining the effectiveness of electronically matched resources in improving children’s MH symptoms is needed.

Theoretical background: The rapid and exponential technological advancements have far-reaching impacts on management information systems, management practices, and human life. The promising outcomes in Artificial Intelligence and cutting-edge research on semantic networks and natural language processing have motivated the authors to envision the future of management technology. Purpose of the article: Our paper focuses on the new communication facilities and artificial intelligence models used to process management-type queries in natural language. Research methods: The article discusses recently developed technologies, proposed by Google and Microsoft, notably Google Bard and Bing integrated with ChatGPT-4. Both chatbots use Generative AI methods and large language models to understand domain-based queries and generate answers. Main findings: The practical and social implications of new models in management practice are discussed. To illustrate the qualities and weaknesses of the features of new technologies, four examples of management decision-making are discussed. The case studies also show differences between these two technologies. Finally, the paper concludes by summarizing the expectations and limitations of Generative AI applications in management. The paper is one of the first publications describing and demonstrating the idea of interfaces in natural language in business-oriented applications.

Background/Objectives: This review summarizes the current knowledge about factors that affect the physical characteristics of urine. It highlights proper urine sample collection and displays factors like diet, hydration status, and medications that can alter urine color, odor, clarity, specific gravity and pH. Results: Urinalysis is a minimally invasive examination of a patient’s health, especially concerning nephrological and endocrinological abnormalities, as well as dietary habits and stimulants used. Certain deviations in appearance, composition or frequency/pain during urination may indicate an ongoing disease process in the body. Based on laboratory results, further medical treatment is determined. The reason for a change in the color of the urine, for its clouding or intense odor may be a disease, as well as the consumption of food, medication, intensive physical exercise or inadequate hydration of the body. Well-standardized procedures for collecting, transporting, preparing and analyzing samples should become the basis for an effective diagnostic strategy in urinalysis. It is worth noting that pharmacists in pharmaceutical care are often the first people to whom a patient turns for health advice and for the interpretation of simple laboratory tests. Acquiring the ability to interpret the results of laboratory tests and the principles of proper sampling for laboratory tests is indispensable in the process of possible counseling and providing reliable answers to patients’ questions. Conclusions: Although urinalysis is not recommended as a routine screening tool for the general population, it can prove to be a valuable source of patient health data in some cases as the data will be useful to physicians and pharmacists to more effectively diagnose and better care for patients.

Introduction: Herbal medicine has been growing in popularity over the last few years. One of the most often used herbal remedy is Withania somnifera, more widely known as Ashwagandha Now known for its anti-stress, anti-inflammatory, antioxidant, anti-cancer, anti-anxiety properties it ranks as a cure-all. However, there is a rising amount of alarming reports regarding its safety. It has been observed that its effects are not always beneficial, and for some patients the risks of taking it may be greater than the promoted benefits. Aim of study: The aim of this paper is to evaluate possible risks connected to Withania Somnifera consumption based on available research articles and case reports. Materials and methods: This article is based on the literature found in the PubMed Database from the period of 2004-2024 with the use of keywords such as “Ashwagandha”; “Withania Somnifera”, “herbal medicine”;”complementary medicine”;“liver injury”; “thyrotoxicosis”; “adrenal insufficiency”;”autoimmune diseases”. Results: The outcomes of all the reviewed studies in this paper indicate that Withania Somnifera might cause a wide range of side effects. They include herb induced liver injury, endocrine complications such as thyrotoxicosis and adrenal insufficiency, acute graft rejection in a kidney transplant recipient and possible contribution to the onset of new autoimmune disease in patient with the history of autoimmune disorders. Conclusion: Further long-term research is needed on the Ashwaghanda’s benefits but particularly on its safety and potential side effects. The common education on the risks of taking herbal supplements should be carried out among health professionals and the rest of the society. Ashwagandha should not be used by patients with liver, endocrine and autoimmune disorders as well as transplant recipients.

Introduction and Purpose: Iron deficiency alongside anaemia is one of the most significant global health concerns with potentially long-lasting implications on child development and health outcomes. The period of infancy represents a crucial phase of central nervous system maturation, rendering infants particularly susceptible to the adverse effects of iron deficiency. It is therefore crucial to pay close attention to this issue. The aim of this review is to elucidate the neurological implications of iron deficiency in infancy and emphasize the necessity of implementing preventive strategies to safeguard child development. State of Knowledge: Iron deficiency in infancy can result in impairments of brain development. Extensive research highlights the influence of this micronutrient on various physiological processes, including the synthesis of neurotransmitters, neuronal metabolism, myelination, synaptogenesis and gene expression. Furthermore, iron deficiency during infancy is associated with adverse developmental outcomes, including cognitive, motor, and socioemotional deficits. Long-term follow-up studies have elucidated the enduring neurological consequences of iron deficiency in infancy, with effects extending into childhood and beyond. Summary: Given that the changes that occur during the infantile period are often irreversible and have long-lasting implications for future development, it is of the utmost importance to prioritize prevention strategies.

Introduction: Matcha, a finely powdered form of green tea, has recently gained global popularity due to its vibrant green color, distinctive taste, and versatile applications in various food products. Despite its promising nutritional profile, matcha has not received significant attention in the academic community compared to traditional green tea. Purpose of work: The primary objective of this review is to provide a comprehensive overview of the current understanding of matcha's biological properties and its potential health benefits. Methods and materials: A review of the literature available in the PubMed database and Google Scholar, the following keywords were searched: "matcha", “catechin", "EGCG", “cognitive function”, “green tea” State of knowledge: Existing studies have demonstrated that matcha exhibits anticancer properties, enhances cognitive function, improves cardio-metabolic health, and modulates the gut microbiome. Moreover, matcha is known for its anti-inflammatory and antioxidant properties. Summary: This review summarizes the latest research findings on matcha green tea and its potential health benefits. While animal studies have shown promising results, our knowledge of matcha's effects on human health remains limited. Further randomized controlled trials are necessary to fully elucidate its potential health-promoting effects. Therefore, we advocate for continued research into matcha's properties and its integration into dietary practices to promote overall health and well-being.

Introduction: Migraine is one of the most prevalent types of headache and is a subject of many clinical trials. There are various risk factors associated with migraine occurrence, from hormonal and genetic to environmental. It is observed that some migraineurs have specific psychological features- sometimes called as migraine personality. This encouraged researchers to evaluate migraine patients in terms of psychiatric co-existing conditions. Aim of study: The main aim of the study was to examine the relationship between migraine and psychiatric comorbidities, primarily personality disorders. Materials and methods: This article is based on the literature found in PubMed and Google Scholar Database with the use of keywords such as ”migraine”, “headache factors”, “personality disorder”, “migraine personality”, “migraine education”, “borderline personality disorder”, “anxious personality disorder”, “migraine health”, “depression and migraine”, “medication over-use in migraine”, “migraine comorbidities”, “depression”, “anxiety”. Results: Investigation of available literature revealed the connection between migraine and personality disorders. Psychiatric comorbidities worsen the treatment prognosis, are a risk factor of medication overuse and chronic headaches. Conclusion: Psychiatric comorbidities are frequent among migraineurs. Clinical evaluation of these patients should be complex and contain psychological and psychiatric analysis, especially in patients resistant to standard treatment.

Introduction and purpose: Polycystic ovary syndrome is the most common endocrinopathy in women, with a prevalence ranging from 10% to 13%. Oxidative stress and decreased antioxidant levels contribute to the development of various diseases, and one of them is polycystic ovary syndrome. The aim of this review is to provide an overview of the current knowledge about the effects of antioxidant administration in PCOS treatment. A brief description of the state of knowledge: Oxidative stress is an imbalance between increased levels of reactive oxygen species and a decreased efficiency of antioxidant mechanisms, which can potentially cause damage. The harmful effects of free radicals might be neutralized by antioxidants obtained from the diet, such as polyphenols, vitamins C, and E. These compounds improve several aspects of the PCOS pathomechanism, including hormonal imbalance, glucose metabolism, lipid profile, and ovarian functionality. Conclusions: The outcomes of all the reviewed studies in this paper indicate that antioxidants such as resveratrol, curcumin, vitamin C and E, N-acetylcysteine, and melatonin have therapeutic potential in the management of PCOS. However, currently antioxidant therapies cannot be recommended in PCOS therapy since there is a need for more prospective randomized clinical trials on a larger sample to establish a long-term effects of antioxidants supplementation in PCOS, the optimal dosage, and finally to assess which antioxidant is the most efficient in PCOS treatment.

The global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous microorganisms. This phenomenon poses a serious threat to public health. Notably, the significance of tigecycline, a member of the antibiotic group glycylcyclines and derivative of tetracyclines has increased. Tigecycline is one of the last-resort antimicrobial drugs used to treat complicated infections caused by multidrug-resistant (MDR) bacteria, extensively drug-resistant (XDR) bacteria or even pan-drug-resistant (PDR) bacteria. The primary mechanisms of tigecycline resistance include efflux pumps’ overexpression, tet genes and outer membrane porins. Efflux pumps are crucial in conferring multi-drug resistance by expelling antibiotics (such as tigecycline by direct expelling) and decreasing their concentration to sub-toxic levels. This review discusses the problem of tigecycline resistance, and provides important information for understanding the existing molecular mechanisms of tigecycline resistance in Enterobacterales. The emergence and spread of pathogens resistant to last-resort therapeutic options stands as a major global healthcare concern, especially when microorganisms are already resistant to carbapenems and/or colistin.

Background: Food–drug interactions (FDIs) may alter drug pharmacokinetics and pharmacodynamics, modifying the whole therapy’s effectiveness. Some of them cause the attenuation of drug effects, while others inhibit the medicines’ metabolism resulting, in too high concentrations of the medicine in the body. Thus, some healthcare professionals—doctors, pharmacists or dieticians—should be aware of the possibility of food–drug interactions. This study aimed to assess knowledge of food–drug interactions among students of pharmacy, medicine, stomatology, medical analysis and dietetics and students of the college of further medical education for pharmacy technicians. Methods: Students (n = 820) completed a custom-made questionnaire. The relationships between the continuous variables were analysed on the basis of Pearson’s correlation coefficient. To verify the predictors of objective students’ knowledge about food–drug interactions, a multiple linear regression model with analysis of covariance (ANCOVA) was used. The Kruskal–Wallis test was performed to compare the total scores the respondents received for questions assessing their objective knowledge of FDI. Results: Students’ objective knowledge of FDIs correlated positively with their year of study and their self-evaluation of it. It was also significantly influenced by the field and mode of studies and by the fact that the issue had been discussed during the courses. Conclusions: Most students of the medical university had serious deficiencies in their knowledge of food–drug interactions. This is of particular concern for future doctors and dentists. Among the respondents, pharmacy students stood out, as their FDI knowledge was greater. The issue of food–drug interactions should be more widely taught at medical universities, which was emphasised by the respondents themselves.

Abstract With the advancement in smart electronic devices and self‐powered devices, the demand for piezoelectric polymers has found potential research interest. Among these, electrospun polyvinylidene fluoride (PVDF) fibers have gained attention for energy harvesting due to their flexibility and higher piezoelectric coefficient. In the current work, various methods are compared to enhance PVDF's piezoelectric properties, including different solvents (DMAc, DMF), conductive filler (rGO), and annealing as post‐treatment. The results indicate that PVDF/rGO fibers in DMAc solvent exhibit the highest β phase fraction and crystallinity. Moreover, for the first time, the piezoelectric properties of PVDF/rGO electrospun single fiber is presented using high voltage switching spectroscopy piezoelectric force microscopy (HVSS‐PFM). The highest piezoelectric coefficient (d33) is measured for PVDF/DMAc‐rGO composite fibers. Notably, PVDF/rGO in DMAc solvent significantly improves the piezoelectric coefficient, leading to a remarkable fourfold increase in power density compared to pure PVDF, making it a promising material for energy harvesting applications.

All over the world, birds’ eggs are an important and valuable component of the human diet. This study aimed to compare the content of lipid components and their nutritional value as well as iron and zinc levels in chicken and quail eggs commonly available on the market. In egg lipids, unsaturated fatty acids were dominant, especially oleic acid, the content of which was about 40% of the total fatty acids (TFAs). Linoleic acid was the major polyunsaturated fatty acid. Compared to other products of animal origin, eggs were characterized by favorable values of lipid quality indices, especially the index of atherogenicity, thrombogenicity, and the hypocholesterolemic-to-hypercholesterolemic ratio. In the present study, no differences were found in the content of tested nutrients between eggs from different production methods (organic, free-range, barn, cages). Based on linear discriminant analysis, inter-breed differences were noticed. Cluster analysis showed that eggs enriched in n3 PUFAs (according to the producers’ declarations) differed from other groups of chicken eggs. However, in eggs from one producer only, the amount of EPA and DHA exceeds 80 mg per 100 g, entitling the use of the nutrition claim on the package. Quail eggs differed from chicken eggs in FA profile and cholesterol and iron levels.

Cholesterol oxidation products (COPs) are contaminants of food of animal origin. Increased levels of these compounds in the human body are associated with an increased risk of many non-communicable diseases. Dairy products are mentioned among the main sources of these compounds in the diet. The objective of this study was to evaluate the contents of cholesterol and its oxidized derivatives in eleven groups of dairy products, willingly consumed in European countries. The levels of COPs were determined by applying the GC-TOF/MS method. In the tested products, cholesterol and its oxidation derivatives, such as 7-ketocholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, 5,6β-epoxycholesterol and 5,6α-epoxycholesterol, were determined. The studied dairy products differed in their contents and profiles of oxysterols. The highest contents of COPs were found in cheese with internal mold (13.8 ± 2.5 mg kg−1) and Cheddar (11.7 ± 3.5 mg kg−1), while the lowest levels were detected in yoghurt (0.94 ± 0.30 mg kg−1) and kefir (0.57 ± 0.11 mg kg−1). 7-ketocholesterol and 5,6β-epoxycholesterol were the dominant oxysterols. The ratio of oxidized derivatives to total cholesterol was on average 1.7%. Our results confirmed that dairy products are an important dietary source of COPs. Their levels should be monitored in dairy products to provide the best health quality.

The aim of our study was to analyse the effect of supplementation with various forms of genistein (nano-, micro-, and macro-) on the mineral status of rat femurs in conditions of DMBA-induced mammary gland neoplasia. Thirty-two 30-day-old Sprague Dawley rats were used in the study. The rats were divided into four experimental groups: a control group (without supplementation) and groups supplemented with nanosized (92 ± 41 nm), microsized (587 ± 83 nm), and macrosized genistein. Micromorphometric and histological examination of the rat femurs were performed, as well as analysis of the weight and mineral composition (17 elements). Quadrupole ICP-MS was used for analysis of all trace elements. Supplementation with genistein (nano-, micro-, and macro-) was shown to cause changes in the mineral composition of the bones. In the rats receiving nanogenistein, disintegration of the bone tissue was observed. The femurs of these animals had higher content of calcium (by nearly 300%) and potassium (by 25%) than the other groups, while the level of magnesium was about 22% lower. In the case of microelements, there were increases in copper (by 67%), boron (48%), manganese (13%), and nickel (100%), and a 16% decrease in strontium compared to the bones of rats without genistein supplementation. Changes in micromorphometric parameters, resulting in increased bone fragility, were observed. Administration of genistein was found to have an effect on the amount of trace elements in the bone tissue of rats with breast cancer.

Cholesterol present in food of animal origin is a precursor of oxysterols (COPs), whose high intake through diet can be associated with health implications. Evaluation of the content of these contaminants in food is associated with many analytical problems. This work presents a GC-TOF/MS method for the simultaneous determination of squalene, cholesterol and seven COPs (7-ketocholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestanetriol). The sample preparation procedure includes such steps as saponification, extraction and silylation. The method is characterized by high sensitivity (limit of quantification, 0.02–0.25 ng mL−1 for instrument, 30–375 μg kg of sample), repeatability (RSD 2.3–6.2%) and a wide linearity range for each tested compound. The method has been tested on eight different animal-origin products. The COP to cholesterol content ratio in most products is about 1%, but the profile of cholesterol derivatives differs widely (α = 0.01). In all the samples, 7-ketocholesterol is the dominant oxysterol, accounting for 31–67% of the total COPs level. The levels of the other COPs range between 0% and 21%. In none of the examined products are cholestanetriol and 25-hydroxycholesterol present. The amount of squalene, which potentially may inhibit the formation of COPs in food, ranges from 2 to 57 mg kg−1.

The changes in body composition during androgen deprivation therapy (ADT) in patients suffering from prostate cancer (PCa) are recognized by professionals more often as biomarker for effective treatment. The aim of this study was to investigate the impact of ADT on the sarcopenia development in PCa. The following databases were used: PubMed, Embase, Web of Science and Scopus databases. Out of 2183 studies, 7 were included in this review. The fixed-effect model was used in the meta-analysis. A significant increase in SATI (Subcutaneous Adipose Tissue Index) of 0.32 (95% CI: 0.13–0.51) p = 0.001, decrease in SMI (Skeletal Muscle Index) of −0.38 (95% CI: −0.57 to −0.19) p < 0.0001, and SMD (Skeletal Muscle Density) of −0.46 (95% CI: −0.69 to −0.24) p < 0.0001 were observed. No statistical association was visible between ADT and changes in BMI (Body Mass Index), 0.05 (95% CI: −0.18–0.28), p = 0.686, and VATI (Visceral Adipose Tissue Index): 0.17 (95% CI: −0.02 to 0.37), p = 0.074. In conclusion, the ADT significantly contributes to the body composition changes and sarcopenia development.

ObjectiveThis systematic review examined the effectiveness of Emergency Department-based and initiated youth suicide prevention interventions for suicide attempts, suicidal ideation, hospitalization, family system functioning, and other mental health symptoms.MethodsWe searched five databases for randomized controlled trial (RCT) studies that examined Emergency Department-based and initiated suicide prevention interventions among youth aged 10 to 18 years old between May 2020 to June 2022. Using Cohen's d and 95% confidence interval as our standardised metrics, we followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) and Synthesis Without Meta-Analysis in Systematic Reviews (SWiM) guidelines when synthesizing, interpreting, and reporting the findings of this review.ResultsFive studies were included in this review. Findings were first synthesized according to the targeted population of the study intervention and this review's outcomes. Two interventions were effective for decreasing depressive symptoms, hospitalization recidivism, and/or increasing family empowerment. There were no interventions that reduced subsequent suicide attempts. A meta-analysis was not conducted due to the heterogeneity of the data.ConclusionA need exists to develop and evaluate Emergency Department-based and initiated youth suicide prevention interventions that can be successfully and sustainably implemented in practice. Future research should focus on evaluating the components of interventions that effectively mitigate suicide risk among high-risk youth.

Celem artykułu jest ukazanie specyfiki obecności studentów zagranicznych studiujących na uczelniach wyższych z uwzględnieniem kierunków pedagogicznych. Na początku artykułu omówiono zagadnienia jakimi są: internacjonalizacja uczelni wyższych, jej wyzwania oraz związane z nią możliwości. Następnie przedstawiono dane ilościowe obrazujące specyfikę obecności studentów zagranicznych na uczelniach wyższych, zarówno w kontekście światowym jak i polskim (w tym związane z obecnością zagranicznych studentów na kierunkach pedagogicznych). Na końcu zaś zawarto uwagi oraz po postulaty związane z potrzebami oraz działaniami, które mogą przyczynić się do zwiększenia stopnia internacjonalizacji uczelni wyższych w Polsce, w kontekście ogólnym oraz w odniesieniu do kierunków pedagogicznych. Omówione niżej zagadnienia związane z internacjonalizacją oraz jej stanem w Polsce, z uwzględnieniem kwestii odnoszących się do kierunków pedagogicznych, w założeniu autora, powinny pełnić rolę przyczynku do podjęcia kolejnych inicjatyw w kierunku wielowymiarowej popularyzacji tego zjawiska – zarówno w rozważaniach teoretycznych jak i działaniach praktycznych.

Introduction The COVID-19 pandemic has impacted the mental health (MH) of children, adolescents and parents. Whereas youth with MH disorders and neurodevelopmental disorders (NDD) may be at higher risk for exacerbations in emotional and behavioural distress, children and adolescents without pre-existing MH disorders or NDD may also experience MH deterioration due to increases in stress, changes in health behaviours, loss of activities/school closures or loss of resources. Little is known about the impact of the COVID-19 emergency measures (EMs) on children’s MH over the course of the pandemic.Methods and analysis Longitudinal study of four well-established, pre-existing cohorts in Ontario (two recruited in clinical settings, two recruited in community settings). Primary outcomes include the impact of EMs on six MH domains: depression, anxiety, irritability, inattention, hyperactivity and obsessive–compulsive behaviours. Risk and protective factors related to youth MH profiles and trajectories will be identified. In addition, the effects of school mitigation strategies, changes in MH services and family factors (ie, parental MH, economic deprivation and family functioning) on children’s MH will be examined. Data will be collected via repeated online survey measures selected to ensure reliability and validity for the proposed populations and distributed through the pandemic periods.Ethics and dissemination The study was approved by institutional research ethics boards at participating research sites. Results will be disseminated through a robust knowledge translation partnership with key knowledge users. Materials to inform public awareness will be co-developed with educators, public health, and MH and health service providers. Connections with professional associations and MH advocacy groups will be leveraged to support youth MH policy in relation to EMs. Findings will further be shared through conference presentations, peer-reviewed journals and open-access publications.

Over the past few years technology especially mobile technologies have advanced significantly, while the cost of using mobile devices have decreased considerably. It is believed that this rapid technological evolution can provide an excellent opportunity to improve the independence of a handicapped person. However, it can also be a source of social exclusion. Certain obstacles such as inadequate built-in accessibility options can limit the use of smart devices amongst this vulnerable group of people. Therefore, functionality and practicality of mobile phones should be taken into consideration. The aim of this review was to determine whether mobile applications are used in the process of monitoring the physical activity, rehabilitation and education of a person with intellectual and/or other disabilities. To examine this issue we reviewed various literature extracts: we used the databases from the National Center for Biotechnology Information (NCBI) focused on PubMed database. According to the method of finding and selected results, we qualified for further analysis of the results, which showed up when searched for key words and expressions (mobile applications, disability, rehabilitation, intellectual disability). We found 115 scientific articles. From this sample, we selected 23 articles related to our study. A significant proportion of the studies carried out seem to confirm that the use mobile applications attempt to support the rehabilitation process of a person with a disability.

W artykule została omówiona problematyka edukacji globalnej w Australii. Została ona scharakteryzowana z uwzględnieniem celu i miejsca w australijskim programie edukacji. Charakterystyka edukacji globalnej w Australii została przygotowana w oparciu o założenia, które są uwzględnione australijskim programie edukacji, Deklaracji Melbournskiej oraz w międzyprzedmiotowych celach edukacyjnych. Ponadto zaprezentowano wybrane działania edukacyjne realizowane w szkołach australijskich, spełniające założenia edukacji globalnej.

N-glycosylation plays an important role in the majority of physiological and pathological processes occurring in the immune system. Alteration of the type and abundance of glycans is an element of lymphocyte differentiation; it is also common in the development of immune-mediated inflammatory diseases. The N-glycosylation process is very sensitive to different environmental agents, among them the pharmacological environment of immunosuppressive drugs. Some results show that high-mannose oligosaccharides have the ability to suppress different stages of the immune response. We evaluated the effects of cyclosporin A (CsA) and rapamycin (Rapa) on high-mannose/hybrid-type glycosylation in human leukocytes activated in a two-way mixed leukocyte reaction (MLR). CsA significantly reduced the number of leukocytes covered by high-mannose/hybrid N-glycans, and the synergistic action of CsA and Rapa led to an increase of these structures on the remaining leukocytes. This is the first study indicating that β1 and β3 integrins bearing high-mannose/hybrid structures are affected by Rapa and CsA. Rapa taken separately and together with CsA changed the expression of β1 and β3 integrins and, by regulating the protein amount, increased the oligomannose/hybrid-type N-glycosylation on the leukocyte surface. We suggest that the changes in the glycosylation profile of leukocytes may promote the development of tolerance in transplantation.

The problem of poverty, both in theory and practice, gained a new meaning with the beginning of the transformation of selected European economies from being centrally planned to market economies. The transition and the accompanying ownership changes resulted in significant shifts in the income distribution, which affected the increase in the stratification of society in terms of material situation and the deterioration of the living conditions of some social groups. Developing and evaluating anti‑poverty programs should be preceded by identifying who is considered poor. Defining poverty is the first and a key step in measuring its characteristics, e.g., its intensity. Hence, the choice of a specific definition of poverty is of fundamental importance for the results of this measurement. The aim of the paper is to assess the material situation of European societies in terms of poverty change in a holistic approach – considering all the information available in international statistics on the problem. To achieve the research objective at the regional data level, we used the URi measure to decompose changes in structure and estimate the direction and intensity of poverty recorded. Further, we evaluated whether the transformations coincide temporarily and spatially. Applying the Hellinger distance (HD) allowed us to identify the significance of trends in changes in the poverty structure, especially in the years of the COVID–19 pandemic, when an increase in the importance of individual structural components of poverty was observed in the analysed European NUTS–2 spatial units. For some economies, the transition was also a consequence of European economic crises or major events of international importance, e.g., sports events or countries acceding to the EU.

Urolithin A (UA) is an ellagitannin-derived postbiotic metabolite which emerged as a promising health-boosting agent, promoting mitophagy, improving skeletal muscle function, and suppressing the inflammatory response. However, phase II intestinal metabolism severely limits its biopotency, leading to the formation of nonactive glucuronides. To address this constraint, a set of new UA derivatives (UADs), conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs), was synthesized. The bioavailability and inhibitory activity of UADs against UA-glucuronidation were evaluated using differentiated Caco-2 cell monolayers. Parallelly, after the administration of tested substances, the transepithelial electrical resistance (TEER) of the cell monolayers was continuously monitored using the CellZscope device. Though investigated UADs did not penetrate Caco-2 monolayers, all of them significantly suppressed the glucuronidation rate of UA, while conjugates with diclofenac increased the concentration of free molecule on the basolateral side. Moreover, esters of UA with diclofenac (DicloUA) and aspirin (AspUA) positively influenced cell membrane integrity. Western blot analysis revealed that some UADs, including DicloUA, increased the expression of pore-sealing tight junction proteins and decreased the level of pore-forming claudin-2, which may contribute to their beneficial activity towards the barrier function. To provide comprehensive insight into the mechanism of action of DicloUA, Caco-2 cells were subjected to transcriptomic analysis. Next-generation sequencing (NGS) uncovered substantial changes in the expression of genes involved, for instance, in multivesicular body organization and zinc ion homeostasis. The results presented in this study offer new perspectives on the beneficial effects of modifying UA's structure on its intestinal metabolism and bioactivity in vitro.

Background Parent and child mental health has suffered during the pandemic and transition phase. Structured and shared parenting may be intervention targets beneficial to families who are struggling with parent or child mental health challenges. Aims First, we investigated associations between structured and shared parenting and parent depression symptoms. Second, we investigated associations between structured and shared parenting and depression, hyperactivity/inattention and irritability symptoms in children. Method A total of 1027 parents in two-parent households (4797 observations total; 85.1% mothers) completed online surveys about themselves and their children (aged 2–18 years) from April 2020 to July 2022. Structured parenting and shared parenting responsibilities were assessed from April 2020 to November 2021. Symptoms of parent depression, child depression, child hyperactivity and inattention, child irritability, and child emotional and conduct problems were assessed repeatedly (one to 14 times; median of four times) from April 2020 to July 2022. Results Parents who reported higher levels of shared parenting responsibilities had lower depression symptoms (β = −0.09 to −0.32, all P < 0.01) longitudinally. Parents who reported higher levels of shared parenting responsibilities had children with fewer emotional problems (ages 2–5 years; β = −0.07, P < 0.05), fewer conduct problems (ages 2–5 years; β = −0.09, P < 0.01) and less irritability (ages 13–18 years; β = −0.27, P < 0.001) longitudinally. Structured parenting was associated with fewer conduct problems (ages 2–5 years; β = −0.05, P < 0.05). Conclusions Shared parenting is beneficial for parent and child mental health, even under chaotic or inflexible life conditions. Structured parenting is beneficial for younger children.

Abstract Background Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services. Methods Using a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N = 1275 individuals with ASD/NDD (age = 11.0 ± 3.6 years; n females = 277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups. Results Clustering revealed four subgroups. One subgroup—broad symptom worsening only (20%)—included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup. Limitations Notable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic. Conclusions Concomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis.

Abstract Background Low acuity presentations to Australian emergency departments drive long wait times, higher costs and may be better treated in primary care settings. This study sought to understand factors leading these patients to present to emergency departments. Methods Semi-structured interviews were carried out with patients at two tertiary emergency departments in Sydney during general practitioner opening hours. Nvivo was used to code the interviews and a thematic analysis was carried out to capture the main themes from the interviews. Results Forty-four interviews were included in the analysis across the two sites. They represented a diverse population in terms of ethnicity, education and socioeconomic background. Patient preferences for emergency care were organised into four main themes: (i) patients were referred (either by another health service, work, friend, or family), (ii) emergency department factors (convenience of investigations and severity of symptoms requiring emergency care), (iii) GP factors (does not have a GP, cannot find an appointment with a GP or has previously had a negative experience with a GP) and (iv) personal factors such as their connection to the hospital. Conclusion Multiple factors led patients to seek ED care for low acuity presentations during GP hours. Some of these factors could be addressed to meet patient needs in the community, however this is currently not the case. Addressing these factors to improve access to GP clinics and the availability of services outside the hospital setting could reduce ED presentations and likely improve patient experience.

Kidney Cooling Jacket (KCJ) preserves the kidney graft, wrapped in the jacket, against the too fast time of temperature rise during the operation of connecting a cooled transplant to the patient’s bloodstream. The efficiency of KCJ depends on the stationarity of the fluid flow and its spatial uniformity. In this paper, the fluid velocity field inside the three different KCJ prototypes has been measured using the 20 MHz ultrasonic Doppler flowmeter. The simplified 2D geometrical model of the prototypes has been presented using COMSOL Multiphysics to simulate the fluid flow assuming the laminar flow model. By comparing the numerical results with experimental data, the simplified 2D model is shown to be accurate enough to predict the flow distribution of the internal fluid velocity field within the KCJ. The discrepancy between the average velocity measured using the 20 MHz Doppler and numerical results was mainly related to the sensitivity of the velocity measurements to a change of the direction of the local fluid flow stream. Flux direction and average velocity were additionally confirmed by using commercial colour Doppler imaging scanner. The current approach showed nearly 90% agreement of the experimental results and numerical simulations. It was important for justifying the use of numerical modelling in designing the baffles distribution (internal walls in the flow space) for obtaining the most spatially uniform field of flow velocity.