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Abstract Myodural bridge (MDB) is a dense connective tissue between suboccipital muscle and dura mater. However, there are few reports on the development and maturation of the human MDB. This study aims to explore the developmental relationship between suboccipital muscle and MDB. 30 head and neck specimens from human fetuses (F) ranging from the 12th to 41st week (W) were made into histological sections. The F12W sections showed evidence that the dura mater dominated by fibroblasts, attached to the posterior atlanto-axial membrane (PAAM) which completely sealed the atlanto-axial space. In the F13W stage, myofibrils of the suboccipital muscle fibers increased significantly in number. At the F14W stage, a gap was observed at the caudal end of the PAAM. Numerous myodural bridge-like structures were observed blending into the dura mater through the gap. At the F19W stage, muscle cells mature. Starting at the F21W stage, the MDB were observed as fibroblasts that cross the atlanto-axial interspace and attach to the dura mater. Therefore, the traction generated by the suboccipital muscles seems to promote the maturity of MDB. This study will provide new morphological knowledge to support future research on the function of the human MDB and regulating the development mechanism of MDB.

Abstract State-of-the-art medical studies proved that long noncoding ribonucleic acids (lncRNAs) are closely related to various diseases. However, their large-scale detection in biological experiments is problematic and expensive. To aid screening and improve the efficiency of biological experiments, this study introduced a prediction model based on the nearest neighbor concept for lncRNA–disease association prediction. We used a new similarity algorithm in the model that fused potential associations. The experimental validation of the proposed algorithm proved its superiority over the available Cosine, Pearson, and Jaccard similarity algorithms. Satisfactory results in the comparative leave-one-out cross-validation test (with AUC = 0.96) confirmed its excellent predictive performance. Finally, the proposed model’s reliability was confirmed by performing predictions using a new dataset, yielding AUC = 0.92.

Abstract Three singlet new Higgs superfields and right-handed neutrinos are added to MSSM to obtain $$U(1)_X$$ U ( 1 ) X SSM model. Its local gauge group is $$SU(3)_C\times SU(2)_L \times U(1)_Y \times U(1)_X$$ S U ( 3 ) C × S U ( 2 ) L × U ( 1 ) Y × U ( 1 ) X . In the framework of $$U(1)_X$$ U ( 1 ) X SSM, we study muon anomalous magnetic moment and lepton flavor violating decays $$l_j\rightarrow {l_i\gamma }(j=2,3;i=1,2)$$ l j → l i γ ( j = 2 , 3 ; i = 1 , 2 ) within the mass insertion approximation (MIA). Through the MIA method, we can find the parameters that directly affect the analytical result of the lepton flavor violating decays $$l_j\rightarrow {l_i\gamma }$$ l j → l i γ , which make our work more convenient. We want to provide a set of simple analytic formulas for the form factors and the associated effective vertices, that may be very useful for future phenomenological studies of the lepton flavor violating decays. According to the accuracy of the numerical results which the influence of different sensitive parameters, we come to the conclusion that the non-diagonal elements which correspond to the generations of the initial lepton and final lepton are main sensitive parameters and lepton flavor violation (LFV) sources. This work can provide a clear signal of new physics (NP).

Abstract Computer aided research of lncRNA-disease association is an important way to study the development of lncRNA-disease. The correlation analysis of existing data, the establishment of prediction model, prediction of unknown lncRNA-disease association, can make the biological experiment targeted, improve the accuracy of biological experiment. In this paper, a lncRNA-disease association prediction model based on latent factor model and projection is proposed (LFMP). This method uses lncRNA-miRNA association data and miRNA-disease association data to predict the unknown lncRNA-disease association, so this method does not need lncRNA-disease association data. The simulation results show that under the LOOCV framework, the AUC of LFMP can reach 0.8964. Better than the latest results. Through the case study of lung and colorectal tumors, LFMP can effectively infer the undetected lncRNA-disease association.

Epizootic hemorrhagic disease (EHD) is an infectious viral disease caused by epizootic hemorrhagic disease virus (EHDV) and EHDV frequently circulates in wild and domestic ruminants. Sporadic outbreaks of EHD have caused thousands of deaths and stillbirths on cattle farms. However, not much is known about the circulating status of EHDV in Guangdong, southern China. To estimate the seroprevalence of EHDV in Guangdong province, 2886 cattle serum samples were collected from 2013 to 2017 and tested for antibodies against EHDV using a competitive ELISA. The overall seroprevalence of EHDV reached 57.87% and was highest in autumn (75.34%). A subset of positive samples were serotyped by a serum neutralization test, showing that EHDV serotypes 1 and 5–8 were circulating in Guangdong. In addition, EHDV prevalence always peaked in autumn, while eastern Guangdong had the highest EHDV seropositivity over the five-year period, displaying apparent temporal–spatial distribution of EHDV prevalence. A binary logistic model analysis indicated a significant association between cattle with BTV infections and seroprevalence of EHDV (OR = 1.70, p < 0.001). The co-infection of different serotypes of EHDV and BTV raises a high risk of potential genomic reassortment and is likely to pose a significant threat to cattle, thus urging more surveillance to monitor their circulating dynamics in China.

Porous SiC ceramics were prepared by a new approach combination of carbothermal reduction and subsequent recrystallization sintering. Firstly, micro-sized SiC particles were used as the skeleton, and SiC spherical nanocrystals were in-situ synthesized by the vapor-solid reaction between carbon nanoparticles and silicon monoxide vapor. The shape and diameter of SiC nanocrystals are related to the pristine carbon nanoparticles, showing a shape memory effect. After recrystallization sintering, high purity α-SiC porous ceramics with tailored necking area were obtained by the evaporation-condensation of SiC nanocrystals. A linear relation was revealed between the flexural strength and the value of d/d0 of porous recrystallized SiC (RSiC) ceramics (the neck diameter to coarse micron-sized grains diameter ratio). The necking area and d/d0 value increased with the SiC nanocrystals content, due to the higher saturated vapor pressure resulted in high mass mobility to neck area of SiC nanoparticles. As a result, a remarkable value of d/d0 ~ 99% and outstanding flexural strength of 75.7 MPa could be achieved for the porous RSiC ceramics with ~42% porosity by adding 20 wt.% nano-sized SiC sintered at 1950°C for 2 h.

AIM: To investigate the clinical characteristics, surgical outcome and curative effect of congenital fibrosis of the extraocular muscles(CFEOM). METHODS: The eye exam of members in a Chinese family with CFEOM includes visual acuity, intraocular pressure, dilated fundus exam, extraocular muscle function test, orbital CT scan, and ultrasound. We did extraocular muscle surgery or frontalis suspension procedure for affected subjects in the family. RESULTS: The incidence of CFEOM in this family was 31%. All patients were affected bilateraly with symptom of congenital eye movement disorder, ptosis, hypotropia, perverted convergence on upgaze and chin up head position. As the age grows, the diseases worsen unobviously. No other systemic disorder was found. Surgical treatment improved the anomalous head position although the ocular movement disorder preserved. CONCLUSION: The pattern of inheritance in our serial patients are autosomal dominant. Surgery can improve chin up head position and cosmetic appearance. However, the eye movement deficiency cannot be improved.

The corrosion behavior of keyhole-free friction stir spot welded joints of dissimilar 6082 aluminum alloy and DP600 galvanized steel in 3.5% NaCl solution has been investigated by the immersion test and electrochemical analysis. The surface of the aluminum alloy produced exfoliation and pitting corrosion. The pitting occurred seriously on the interface of the 6082 aluminum alloy, but the steel had no corrosion. The corrosion galvanic couples were formed between elements of Si and Fe with a high electrode potential, and Mg and Al with a low electrode potential, around them. Mg and Al elements of Mg2Si and Si-containing solid-solution phase α (Al) preferentially became an anodic dissolution and formed exfoliation corrosion around the Si elements. Fe-rich phase θ (Al3Fe) as the cathode caused corrosion of Mg and formed pitting around Mg-rich phase β (Al3Mg2) as the anode. The sequence of the corrosion resistance of different areas of the joints (with decreasing corrosion resistance) was WNZ (Weld Nugget Zone) > TMAZ (Thermo-mechanically Affected Zone) > BM (Base Metal) > HAZ (Heat-affected Zone). The joints of keyhole-free FSSW (Fiction Stir Spot Welding) of dissimilar 6082 aluminum alloy and DP600 galvanized steel have better corrosion resistance than base metal in 3.5% NaCl solution.

The title compound, C13H13N5O, crystallizes with two molecules in the asymmetric unit. The crystal structure is stabilized by intramolecular N—H...N and N—H...O hydrogen bonds. The dihedral angles between the pyrazine ring and the 4-aminolphenyl ring are 2.5 (1) and 6.5 (1)° in the two molecules.