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Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in therapeutic failure. An ex vivo study was undertaken using CPB devices primed and then dosed with cefazolin and samples were obtained over 1 hour of recirculation. Twelve experimental runs were conducted using different CPB device sizes (neonate, infant, child, and adult), device coatings (Xcoating™, Rheoparin®, PH.I.S.I.O), and priming solutions. The time course of saturable binding, using Bmax (binding capacity), Kd (dissociation constant), and T2off (half‐time of dissociation), described cefazolin adsorption. Bmax estimates for the device sizes were neonate 40.0 mg (95% CI 24.3, 67.4), infant 48.6 mg (95% CI 5.97, 80.2), child 77.8 mg (95% CI 54.9, 103), and adult 196 mg (95% CI 191, 199). The Xcoating™ Kd estimate was 139 mg/L (95% CI 27.0, 283) and the T2off estimate was 98.4 min (95% CI 66.8, 129). The Rheoparin® and PH.I.S.I.O coatings had similar binding parameters with Kd and T2off estimates of 0.169 mg/L (95% CI 0.01, 1.99) and 4.94 min (95% CI 0.17, 59.4). The Bmax was small (

Several agricultural reforms are in progress in the UK following its withdrawal from the EU. This is an opportunity to formulate a Welsh Soils Policy Statement (SPS) that raises the status of soils and ensures that their protection and sustainable management are integrated into future policy. We share and reflect on our novel approach at co-producing a SPS for Wales involving academic researchers and policy teams and provide clear insights into soil policy development. Building consensus among the various government departments and agencies formed the basis of our approach. For pragmatic reasons, it was decided to focus on agricultural soils, which cover 85% of Wales. A rigorous evidence review and synthesis formed the foundation for the development of the SPS, which devises a vision, and primary and secondary objectives for Welsh agricultural soils. A first draft was conceived by the researchers, with further iterations developed between the researchers and the policy team. The researchers were embedded into the policy teams, and this proved to be an effective mechanism for evidence-based policy development that also enhances the science-policy relationship in the longer term. New structures and incentives that promote the engagement between researchers and policymakers should be developed to support environmental policymaking across the board.