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1. Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Author

L. Mathur, B. Szalai, N. H. Du, R. Utharala, M. Ballinger, J. J. M. Landry, M. Ryckelynck, V. Benes, J. Saez-Rodriguez, and C. A. Merten

Subjects
Science
Abstract

Current screens to assess tumour drug resistance require a large amount of material, normally not available from patients. Here the authors report CombiSeq, a scalable microfluidic workflow to screen hundreds of drug combinations in picoliter-size droplets using transcriptome changes as a readout.

Published
2022
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