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Abstract Background In preterm infants with Respiratory Distress Syndrome (RDS), Less Invasive Surfactant Administration (LISA) has been established to reduce the need of mechanical ventilation and might improve survival rates without bronchopulmonary dysplasia. The aim of this study was to investigate whether NICU care has changed after introduction of less invasive surfactant administration (LISA), with regard to diagnostic and therapeutic procedures in the first week of life. Methods Infants with gestational age

A recent report by the Institute for Health Metrics and Evaluation (IHME) highlights that mental health receives little attention despite being a major cause of disease burden. This paper extends previous assessments of development assistance for mental health (DAMH) in two significant ways; first by contrasting DAMH against that for other disease categories, and second by benchmarking allocated development assistance against the core disease burden metric (disability-adjusted life year) as estimated by the Global Burden of Disease Studies.In order to track DAH, IHME collates information from audited financial records, project level data, and budget information from the primary global health channels. The diverse set of data were standardised and put into a single inflation adjusted currency (2015 US dollars) and each dollar disbursed was assigned up to one health focus areas from 1990 through 2015. We tied these health financing estimates to disease burden estimates (DALYs) produced by the Global Burden of Disease 2015 Study to calculated a standardised measure across health focus areas-development assistance for health (in US Dollars) per DALY.DAMH increased from USD 18 million in 1995 to USD 132 million in 2015, which equates to 0.4% of total DAH in 2015. Over 1990 to 2015, private philanthropy was the most significant source (USD 435 million, 30% of DAMH), while the United States government provided USD 270 million of total DAMH. South and Southeast Asia received the largest proportion of funding for mental health in 2013 (34%). DAMH available per DALY in 2013 ranged from USD 0.27 in East Asia and the Pacific to USD 1.18 in the Middle East and North Africa. HIV/AIDS received the largest ratio of funds to burden-approximately USD150 per DALY in 2013. Mental and substance use disorders and its broader category of non-communicable disease received less than USD1 of DAH per DALY.Combining estimates of disease burden and development assistance for health provides a valuable perspective on DAH resource allocation. The findings from this research point to several patterns of unproportioned distribution of DAH, none more apparent than the low levels of international investment in non-communicable diseases, and in particular, mental health. However, burden of disease estimates are only one input by which DAH should be determined.

Background: A country's wealth is an established predictor of population health outcomes. The distribution of wealth within a country is also associated with health outcomes, yet the relation between poverty and health outcomes has not been as widely assessed in cross-country studies because of insufficient data. In this study, we construct 22 complete, yet distinct, poverty data series and test how poverty can explain variation in health. Methods: The World Bank's International Comparison Program estimates the number of people living at or below US$1·25 per day using more than 800 household surveys. However, this data series is far from complete. We build from the World Bank dataset and use covariates and intertemporal trends to generate a complete data series for 129 countries for 1990–2013. We used a variable selection process based on linear regression and Bayesian model selection to derive a tractable set of predictors. To predict national poverty rates at 51 different income thresholds, we used 20 variants of three models and relied on out-of-sample validation to choose the best model. Finally, we use fixed-effects linear regression techniques to test how national poverty rates are associated with changes in adult and child mortality. Findings: A three-stage model based on multiple imputation, hierarchical random-effects estimation, and Gaussian process regression out performs all other methods used to estimate national poverty rates. We noted that the number of people living on $1·25 per day is being reduced in most parts of the world, although in some regions of Africa the extreme poverty count is increasing. When poverty is defined as living on $5·00 per day, we see that the number of people living in poverty is increasing in 88 countries (68·2%) in our sample. Finally, our analysis shows that escaping extreme poverty, as currently defined as living at or below $1·25 per day, is not sufficient to produce great improvements in population health. When poverty is redefined at a larger income threshold, reductions in national poverty rates predict more substantial population health gains. Interpretation: Since 1990, there has been a great deal of progress made in reducing the number of people living at or below $1·25 per day. We provide evidence that increasing an individual's income above $1·25 is not associated with dramatically improved health. Instead, an income closer to $5·00 per day seems to be more closely associated with improved population health. This research highlights that, while reducing the number of people living at or below $1·25 per day is important for better health outcomes, more income is required for substantial improvements in population health. Funding: The Bill and Melinda Gates Foundation.

Elevated atmospheric CO2 levels and increasing nitrogen deposition both stimulate plant production in terrestrial ecosystems. Moreover, nitrogen deposition could alleviate an increasing nitrogen limitation experienced by plants exposed to elevated CO2 concentrations. However, an increased rate of C flux through the soil compartment as a consequence of elevated CO2 concentrations has been suggested to limit C sequestration in terrestrial ecosystems, questioning the potential for terrestrial C uptake to mitigate increasing atmospheric CO2 concentrations. Our study used data from 77 published studies applying elevated CO2 and/or N fertilization treatment to monitor carbon storage potential in grasslands, and considered the influence of management practices involving biomass removal or irrigation on the elevated CO2 effects. Our results confirmed a positive effect of elevated CO2 levels and nitrogen fertilization on plant growth, but revealed that N availability is essential for the increased C influx under elevated CO2 to propagate into belowground C pools. However, moderate nutrient additions also promoted decomposition processes in elevated CO2, reducing the potential for increased soil C storage. An important role was attributed to the CO2 response of root biomass in soil carbon responses to elevated CO2, since there was a lower potential for increases in soil C content when root biomass increased. Future elevated CO2 concentrations and increasing N deposition might thus increase C storage in plant biomass, but the potential for increased soil C storage is limited.