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Habteyes Hailu Tola, Dinka Fikadu Gamtesa TB/HIV Research Directorate, Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Habteyes Hailu TolaTB/HIV Research Directorate, Ethiopian Public Health Institute, P.O. Box: 1242, Addis Ababa, EthiopiaTel +251 978 641 821Fax +251 11 2758634Email habtetola@gmail.comBackground: In the previous years, efforts have been made to reduce the inequality gap in newborn and child health interventions in Ethiopia. However, there is still limited evidence on the extent and trends of inequality on newborn and child health interventions. Thus, we aimed to assess newborn and child health interventions, inequality levels, and trends during four demographic and health survey periods based on inequality dimensions: economic status, education level, residency, and child’s sex in Ethiopia.Methods: We conducted an inequality analysis on four periods (2000, 2005, 2011, and 2016) of the Ethiopian Demographic and Health Survey (EDHS) data. We estimated inequality related to economic and education status using percentage, relative concentration index, and slope index, while mean percentage difference and ratio were used to assess inequality due to residency and child’s sex.Results: The coverage of services was concentrated in the richest quintile, highly educated families, and urban dwellers. Child and newborn health intervention service coverage improvement in the past four survey periods was less than 10.0% for all services, and there is high disparity between sub-national regions. Full immunization-related inequality was highest in Ethiopia compared to four east-central African countries.Conclusion: Increasing service coverage and improving equitable access to routine immunizations could fill the existing inequality gap while focusing on the underserved group. In addition, strengthening regular monitoring processes is also vital to know those left behind.Keywords: health inequality, child health interventions, health equity, vaccination, immunization, children