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Abstract Having previously reported that separating the two stages of echo-enabled harmonic generation (EEHG) with one or more bending magnet (BM) sections allows the BMs to serve as the desired source of momentum compaction, here we demonstrate that this arrangement can greatly reduce the total energy modulation required by any 4th generation synchrotron light source, leading to higher repetition rates as well as stronger coherent radiation output power, with significant benefits. Since the EEHG beamline performance is mainly determined by the momentum compaction, beam emittances and beta functions of a storage ring lattice, allowing for different separations between the two stages is a straightforward way to increase the momentum compaction of chicane 1. This also enables pump-probe capabilities in a novel context, where twin-pulse seeding on the same electron bunch would allow two distinct radiation pulses with an adjustable delay in the range of 0.1 to 10 ps. In the twin-pulse seeding scheme, the same electron bunch could undergo modulation from two distinct laser pulses. Later stages would produce independent harmonics in subsequent straight sections. There are two variations of this twin-pulse seeding scheme, supporting different scientific applications. With a common modulation in stage 1, the first option allows simultaneously two independent radiation sources, with a full coverage of the EUV (2.5 to 50 nm) to soft X-ray (1.25 to 2.5 nm) spectrum; for the second option, the same stage 2 undulator could generate two coherent pulses both fitting within the FEL bandwidth, or at distinct harmonics. We present particle tracking simulation studies based on the APS-U lattice, including quantum excitation and radiation damping. These simulations indicate that there is no degradation of the modulated longitudinal phase space even when the two stages are separated by as many as 10 BM sections.

Abstract Prebunching via echo-enabled harmonic generation (EEHG) is an efficient way to reduce the radiator length and improve the longitudinal coherence as well as output stability in storage-ring-based free-electron lasers. We propose a conceptual design, which uses two straight sections to seed coherent extreme-ultraviolet (EUV) and soft X-ray emission with nearly MHz repetition rate. To take the large energy spread (10−3) of a storage ring into account and utilize the existing bending magnets between the two straight sections as the first chicane, we implement a special modeling tool, named EEHG optimizer. This tool has been successfully applied to maximize the prebunching with a reasonably low energy modulation, thereby generating intense coherent X-ray pulses within a short undulator length (a few meters) limited by the available space of a storage ring. Numerical simulations confirm that the optimized EEHG parameters can be directly applied to generate a 10 MW scale peak power with fully coherent ultrafast EUV to soft X-ray pulses based on the NSLS-II parameters. This method can be easily extended to other types of diffraction-limited storage rings.

The Advanced Light Source Upgrade will implement on axis single-train swap-out injection employing an accumulator between the booster and storage rings. The accumulator ring (AR) design is a twelve period triple-bend achromat that will be installed along the inner circumference of the storage-ring tunnel. A nonconventional injection scheme will be utilized for top-off off axis injection from the booster into the AR meant to accommodate a large ∼300 nm emittance beam into a vacuum-chamber with a limiting horizontal aperture radius as small as 8 mm. The scheme incorporates three dipole kickers distributed over three sectors, with two kickers perturbing the stored beam and the third affecting both the stored and the injected beam trajectories. This paper describes this “3DK” injection scheme and how it fits the AR’s particular requirements. We describe the design and optimization process, and how we evaluated its fitness as a solution for booster-to-accumulator ring injection.

We present the results from studies of soft x-ray seeding options for the LCLS–II x-ray free electron laser (FEL) at SLAC. The LCLS-II will use superconducting accelerator technology to produce x-ray pulses at up to 1 MHz repetition rate using 4 GeV electron beams. If properly seeded, these pulses will be nearly fully coherent, and highly stable in photon energy, bandwidth, and intensity, thus enabling unique experiments with intense high-resolution soft x-rays. Given the expected electron beam parameters from start to end simulations and predicted FEL performance, our studies reveal echo enabled harmonic generation (EEHG) and soft x-ray self-seeding (SXRSS) as promising and complementary seeding methods. We find that SXRSS has the advantage of simplicity and will deliver 5-35 times higher spectral brightness than EEHG in the 1–2 nm range, but lacks some of the potential for phase-stable multipulse and multicolor FEL operations enabled by external laser seeding with EEHG.

Preliminary studies of harmonic lasing have shown significant promise as a method to produce radiation at higher photon energies for a given electron energy and for a given undulator. The basic idea is to suppress radiation at the fundamental resonant wavelength, and allow radiation at a specific harmonic to grow exponentially without being driven by nonlinear processes at the fundamental. This has several potential benefits: higher photon energies for the same undulator field, plus significantly more power and smaller bandwidth compared to extracting nonlinear radiation at the harmonic after the fundamental has reached saturation. In this paper, we use beam parameters from the current design of LCLS-II to take a critical look at the challenge of suppressing radiation at the fundamental wavelength and to evaluate how much of an improvement in terms of photon energy reach and brightness can be achieved through harmonic lasing. For undulators with adjustable magnetic fields, a scheme is presented which can delay the onset of saturation at the fundamental wavelength by a factor of 2. Performance characteristics and especially spectral brightness are compared to self-seeded beam lines as an alternative method to reduce bandwidth, as well as with more conventional SASE beam lines.

Beam lines using echo-enabled harmonic generation can be designed to have extremely low sensitivity to energy chirps in the electron beam, as shown through theory and detailed simulations. These designs would allow stable and coherent radiation to be produced even when using electron beams with a large amount of shot-to-shot jitter in the longitudinal profile.

In this paper we report on start-to-end simulation of a next generation light source based on a high repetition rate free electron laser (FEL) driven by a CW superconducting linac. The simulation integrated the entire system in a seamless start-to-end model, including birth of photoelectrons, transport of electron beam through 600 m of the accelerator beam delivery system, and generation of coherent x-ray radiation in a two-stage self-seeding undulator beam line. The entire simulation used the real number of electrons (∼2 billion electrons/bunch) to capture the details of the physical shot noise without resorting to artificial filtering to suppress numerical noise. The simulation results shed light on several issues including the importance of space-charge effects near the laser heater and the reliability of x-ray radiation power predictions when using a smaller number of simulation particles. The results show that the microbunching instability in the linac can be controlled with 15 keV uncorrelated energy spread induced by a laser heater and demonstrate that high brightness and flux 1 nm x-ray radiation (∼10^{12} photons/pulse) with fully spatial and temporal coherence is achievable.

A longitudinally and transversely coherent, high repetition rate x-ray source with widely tunable wavelength is desired for a variety of experimental applications. A free electron laser (FEL) powered by an electron beam from a superconducting linac can reach the desired peak and average x-ray power levels with transverse coherence. However, generating longitudinally coherent x-ray pulses is a significant challenge, especially at high repetition rate. This paper presents a one-dimensional theoretical and numerical investigation of a method to achieve longitudinal coherence and high repetition rate simultaneously. We propose a “radiator-first” configuration, wherein an FEL oscillator follows a high gain harmonic generation (HGHG) FEL. The oscillator generates seed power that is directed upstream to initiate the HGHG process in a following electron bunch. This configuration allows for the generation of radiation at short wavelength, which is highly sensitive to energy spread, to occur before the longer wavelength oscillator, whose performance is not seriously degraded by the beam heating in the upstream radiator. The dynamics and stability of this radiator-first scheme is explored analytically and numerically. A single-pass, 1D map is derived using a semianalytic model for FEL gain and saturation. Iteration of the map is shown to be in good agreement with simulations. A numerical example is presented for a soft x-ray FEL.

CERN currently delivers antiprotons for trapping experiments with the antiproton decelerator (AD), which slows the antiprotons down to about 5 MeV. This energy is currently too high for direct trapping, and thick foils are used to slow down the beam to energies which can be trapped. To allow further deceleration to ∼100 keV, CERN is initiating the construction of ELENA, consisting of a ring which will combine rf deceleration and electron cooling capabilities. We describe a simple frictional cooling scheme that can serve to provide significantly improved trapping efficiency, either directly from the AD or first using a standard deceleration mechanism (induction linac or rf quadrupole). This scheme could be implemented in a short time. The device itself is short in length, uses accessible voltages, and at reasonable cost could serve in the interim before ELENA becomes operational, or possibly in lieu of ELENA for some experiments. Simple theory and simulations provide a preliminary assessment of the concept and its strengths and limitations, and highlight important areas for experimental studies, in particular to pin down the level of multiple scattering for low-energy antiprotons. We show that the frictional cooling scheme can provide a similar energy spectrum to that of ELENA, but with higher transverse emittances.

A three-dimensional analysis of radiation generation in a free-electron laser (FEL) is performed in the small signal regime. The analysis includes beam conditioning, harmonic generation, flat beams, and a new scaling of the FEL equations using the six-dimensional beam brightness. The six-dimensional beam brightness is an invariant under Liouvillian flow; therefore, any nondissipative manipulation of the phase space, performed, for example, in order to optimize FEL performance, must conserve this brightness. This scaling is more natural than the commonly used scaling with the one-dimensional growth rate. The brightness-scaled equations allow for the succinct characterization of the optimal FEL performance under various additional constraints. The analysis allows for the simple evaluation of gain enhancement schemes based on beam phase space manipulations such as emittance exchange and conditioning. An example comparing the gain in the first and third harmonics of round or flat and conditioned or unconditioned beams is presented.

One scheme for harmonic generation employs free electron lasers (FELs) with two undulators: the first uses a seed laser to modulate the energy of the electron beam; following a dispersive element which acts to bunch the beam, the second undulator radiates at a higher harmonic. These processes are currently evaluated using extensive calculations or simulation codes which can be slow to evaluate and difficult to set up. We describe a simple algorithm to predict the output of a harmonic generation beam line in the low-gain FEL regime, based on trial functions for the output radiation. Full three-dimensional effects are included. This method has been implemented as a Mathematica® package, named CAMPANILE, which runs rapidly and can be generalized to include effects such as asymmetric beams and misalignments. This method is compared with simulation results using the FEL code GENESIS, both for single stages of harmonic generation and for the LUX project, a design concept for an ultrafast x-ray facility, where multiple stages upshift the input laser frequency by factors of up to 200.

We describe a technique for the generation of a solitary attosecond x-ray pulse in a free-electron laser (FEL), via a process of self-amplified spontaneous emission. In this method, electrons experience an energy modulation upon interacting with laser pulses having a duration of a few cycles within single-period wiggler magnets. Two consecutive modulation sections, followed by compression in a dispersive section, are used to obtain a single, subfemtosecond spike in the electron peak current. This region of the electron beam experiences an enhanced growth rate for FEL amplification. After propagation through a long undulator, this current spike emits a ∼250 attosecond x-ray pulse whose intensity dominates the x-ray emission from the rest of the electron bunch.

The consequences of beam conditioning in four example cases [VISA, a soft x-ray free-electron laser (FEL), LCLS, and a “Greenfield” FEL] are examined. It is shown that in emittance limited cases, proper conditioning reduces sensitivity to the transverse emittance and, furthermore, allows for stronger focusing in the undulator. Simulations show higher saturation power, with gain lengths reduced by a factor of 2 or more. The beam dynamics in a general conditioning system are studied, with “matching conditions” derived for achieving conditioning without growth in the effective emittance. Various conditioning lattices are considered, and expressions derived for the amount of conditioning provided in each case when the matching conditions are satisfied. These results show that there is no fundamental obstacle to producing beam conditioning, and that the problem can be reduced to one of proper lattice design. Nevertheless, beam conditioning will not be easy to implement in practice.

A modified Boris-like integration, in which the spatial coordinate is the independent variable, is derived. This spatial-Boris integration method is useful for beam simulations, in which the independent variable is often the distance along the beam. The new integration method is second order accurate, requires only one force calculation per particle per step, and preserves conserved quantities more accurately over long distances than a Runge-Kutta integration scheme. Results from the spatial-Boris integration method and a Runge-Kutta scheme are compared for two simulations: (i) a particle in a uniform solenoid field and (ii) a particle in a sinusoidally varying solenoid field. In the uniform solenoid case, the spatial-Boris scheme is shown to perfectly conserve for any step size quantities such as the gyroradius and the perpendicular momentum. The Runge-Kutta integrator produces damping in these conserved quantities. In the sinusoidally varying case, the conserved quantity of canonical angular momentum is used to measure the accuracy of the two schemes. For the sinusoidally varying field simulations, error analysis is used to determine the integration distance beyond which the spatial-Boris integration method is more efficient than a fourth-order Runge-Kutta scheme. For beam physics applications where statistical quantities such as beam emittance are important, these results imply the spatial-Boris scheme is 3 times more efficient.

In the past few years, the concept of a high intensity muon storage ring has been pursued as an option for the next generation neutrino source. To produce the high intensity muon beam needed for the successful operation of a neutrino source, on the order of 10^{20} muon decays per year, the phase space occupied by the muon beam must be significantly reduced before the beam is accelerated. The initial transverse emittance of the muon beam before acceleration is assumed to be 9π mm rad. Because of the time limitation imposed by the muon lifetime, the technique employed to accomplish the desired emittance reduction is ionization cooling. In this paper we present two ionization cooling lattice designs, which use solenoidal focusing elements and liquid hydrogen absorbers to reduce the muon beam phase space. We discuss the design concepts and engineering constraints for these lattices and present simulation results obtained using a detailed tracing code with a complete model of muon-matter interactions. The reduction in transverse emittance is approximately a factor of 5. This result is within a factor of 2 of the total cooling requirements for a successful neutrino factory design and within a factor of 1.4 of the requirements for the main cooling section specified in the conceptual design of this machine.

The paper presents the acquisition and data processing approach for the Ground Penetrating Radar (GPR) and laser scanner surveys carried out within the SOS project (the acronym comes from ‘SOtto Siena’, in English ‘Beneath Siena’). SOS is a program aimed to overcome some of the problems and limitations currently present in the study of cities with long-term continuity of life, responding in particular to the need for a better understanding of the city’s ancient fabric and hence to improvements in its conservation by: GPR city survey full coverage (of all the public spaces, streets, squares, courtyards, gardens, etc.), GIS data entry of the historical-archaeological and geoarchaeological knowledge and the development of a 3D Archaeological WEBGIS.The paper discusses the procedure for the creation of a 3D viewer within an already active WEBGIS platform, specifically created for the visualisation and management of archaeological data. The GPR data, once acquired, were exported in 3D in the form of point clouds and subjected to a procedure of cleaning and filtering from noise, so as to eliminate geometries not referable to anomalies and therefore to the presence of buried structures or cavities, and then transformed into mesh to meet the needs of the subsequent process of semantic enrichment. The GPR survey of the underground was flanked by laser scanning of some of the most significant structures in the historic centre (e.g. the cathedral). All 3D geometries were then inserted into the new visualiser via a pipeline using open-source tools and libraries.

Private water supply systems consisting of a domestic well and septic system are used throughout the world where households lack access to public water supply and sewers. In residential areas with a high housing density, septic contamination of private wells is common and associated with multiple health concerns. This situation can give rise to social dilemmas, where individual costs de-incentivize homeowners from investing in enhanced septic systems that would reduce well contamination and bring communal benefits. We combine a stylized game theoretical model with a probabilistic groundwater model to characterize how economic and hydrogeological conditions interact to produce misaligned incentives conducive to social dilemmas. The occurrence of social dilemmas depends on the relative costs of well contamination versus the cost of installing an enhanced septic treatment system and the relative probabilities of cross-contamination versus self-contamination. The game reveals three types of social dilemmas that occur in such systems, with each calling for distinct policy solutions. We demonstrate how the model can be applied to existing systems, using a case study of St. Joseph County, Indiana, where high nitrate contamination rates have raised public health concerns. This analysis represents a step towards identifying alternative policy solutions for a problem that has remained difficult to address for decades.

Streamflow regimes are rapidly changing in many regions of the world. Attribution of these changes to specific hydrological processes and their underlying climatic and anthropogenic drivers is essential to formulate an effective water policy. Traditional approaches to hydrologic attribution rely on the ability to infer hydrological processes through the development of catchment-scale hydrological models. However, such approaches are challenging to implement in practice due to limitations in using models to accurately associate changes in observed outcomes with corresponding drivers. Here we present an alternative approach that leverages the method of multiple hypotheses to attribute changes in streamflow in the Upper Jhelum watershed, an important tributary headwater region of the Indus basin, where a dramatic decline in streamflow since 2000 has yet to be adequately attributed to its corresponding drivers. We generate and empirically evaluate a series of alternative and complementary hypotheses concerning distinct components of the water balance. This process allows a holistic understanding of watershed-scale processes to be developed, even though the catchment-scale water balance remains open. Using remote sensing and secondary data, we explore changes in climate, surface water, and groundwater. The evidence reveals that climate, rather than land use, had a considerably stronger influence on reductions in streamflow, both through reduced precipitation and increased evapotranspiration. Baseflow analyses suggest different mechanisms affecting streamflow decline in upstream and downstream regions, respectively. These findings offer promising avenues for future research in the Upper Jhelum watershed, and an alternative approach to hydrological attribution in data-scarce regions.

The empirical attribution of hydrologic change presents a unique data availability challenge in terms of establishing baseline prior conditions, as one cannot go back in time to retrospectively collect the necessary data. Although global remote sensing data can alleviate this challenge, most satellite missions are too recent to capture changes that happened long ago enough to provide sufficient observations for adequate statistical inference. In that context, the 4 decades of continuous global high-resolution monitoring enabled by the Landsat missions are an unrivaled source of information. However, constructing a time series of land cover observation across Landsat missions remains a significant challenge because cloud masking and inconsistent image quality complicate the automatized interpretation of optical imagery. Focusing on the monitoring of lake water extent, we present an automatized gap-filling approach to infer the class (wet or dry) of pixels masked by clouds or sensing errors. The classification outcome of unmasked pixels is compiled across images taken on different dates to estimate the inundation frequency of each pixel, based on the assumption that different pixels are masked at different times. The inundation frequency is then used to infer the inundation status of masked pixels on individual images through supervised classification. Applied to a variety of global lakes with substantial long term or seasonal fluctuations, the approach successfully captured water extent variations obtained from in situ gauges (where applicable), or from other Landsat missions during overlapping time periods. Although sensitive to classification errors in the input imagery, the gap-filling algorithm is straightforward to implement on Google's Earth Engine platform and stands as a scalable approach to reliably monitor, and ultimately attribute, historical changes in water bodies.

Monitoring the spatial footprint of cyclone impacts by remote sensing offers great potential for assessing the extent of damage and monitoring the resilience of the affected territories. For this purpose, as part of the Renovrisk-Impact project, we have developed two change detection processing chains based on optical (Sentinel-2) and SAR (Sentinel-1) data. These chains have been used to track different events in different regions of the world. In this article we focus on two study sites in Madagascar: the city of Miandrivazo, which was heavily affected by severe rainfall from Cyclone AVA in January 2018, and more recently the town of Marovoay which suffered a major disaster following the passage of tropical storm DIANE in January 2020. The obtained results were evaluated and compared with the Copernicus Emergency Mapping Service product, showing good consistency with this product and between them. These results confirm the potential of these Sentinel data and the developed processing chains for monitoring the impacts of cyclones, but also open up prospects for longer-term monitoring.

This study investigates deep intracontinental earthquakes. Based on field data from exhumed lower crustal pseudotachylytes and mylonites from Lofoten, northern Norway, the authors describe a novel model of earthquake nucleation in the lower crust as a transient consequence of ongoing localised aseismic creep.

Garnet is a high-strength mineral compared to other common minerals such as quartz and feldspar in the felsic crust. In felsic mylonites, garnet typically occurs as porphyroclasts that mostly evade crystal plastic deformation, except under relatively high-temperature conditions. The microstructure of granulite facies garnet in felsic lower-crustal rocks of the Musgrave Ranges (Central Australia) records both fracturing and crystal plastic deformation. Granulite facies metamorphism at ∼1200 Ma generally dehydrated the rocks and produced millimetre-sized garnets in peraluminous gneisses. A later ∼550 Ma overprint under sub-eclogitic conditions (600–700 ∘C, 1.1–1.3 GPa) developed mylonitic shear zones and abundant pseudotachylyte, coeval with the neocrystallization of fine-grained, high-calcium garnet. In the mylonites, granulite facies garnet porphyroclasts are enriched in calcium along rims and fractures. However, these rims are locally narrower than otherwise comparable rims along original grain boundaries, indicating the contemporaneous diffusion and fracturing of garnet. The fractured garnets exhibit internal crystal plastic deformation, which coincides with areas of enhanced diffusion, usually along zones of crystal lattice distortion and dislocation walls associated with subgrain rotation recrystallization. The fracturing of garnet under dry lower-crustal conditions, in an otherwise viscously flowing matrix, requires transient high differential stress, most likely related to seismic rupture, consistent with the coeval development of abundant pseudotachylyte. Highlights. Garnet is deformed by fracturing and crystal plasticity under dry lower-crustal conditions. Ca diffusion profiles indicate multiple generations of fracturing. Diffusion is promoted along zones of higher dislocation density. Fracturing indicates transient high-stress (seismic) events in the lower continental crust.

At mid-crustal conditions, deformation of feldspar is mainly accommodated by a combination of fracturing, dissolution–precipitation, and reaction-weakening mechanisms. In particular, K-feldspar is reaction-weakened by the formation of strain-induced myrmekite – a fine-grained symplectite of plagioclase and quartz. Here we use electron backscattered diffraction to (i) investigate the microstructure of a granodiorite mylonite, developed at ∼ 450 °C during cooling of the Rieserferner pluton (Eastern Alps); and (ii) assess the microstructural processes and the weakening associated with myrmekite development. Our analysis shows that the crystallographic orientation of plagioclase in pristine myrmekite was controlled by that of the replaced K-feldspar. Myrmekite nucleation resulted in both grain-size reduction and anti-clustered phase mixing by heterogeneous nucleation of quartz and plagioclase. The fine grain size of sheared myrmekite promoted grain-size-sensitive creep mechanisms including fluid-assisted grain boundary sliding in plagioclase, coupled with heterogeneous nucleation of quartz within creep cavitation pores. Flow laws, calculated for monomineralic quartz, feldspar, and quartz + plagioclase aggregates (sheared myrmekite) during deformation at 450 °C, show that grain-size-sensitive creep in sheared myrmekite accommodated strain rates several orders of magnitude higher than monomineralic quartz layers deforming by dislocation creep. Therefore, diffusion creep and grain-size-sensitive processes contributed significantly to bulk rock weakening during mylonitization. Our results have implications for modelling the rheology of the felsic middle crust.

Thrust fault systems typically distribute shear strain preferentially into the hanging wall rather than the footwall. The Woodroffe Thrust in the Musgrave Block of central Australia is a regional-scale example that does not fit this model. It developed due to intracontinental shortening during the Petermann Orogeny (ca. 560–520 Ma) and is interpreted to be at least 600 km long in its E–W strike direction, with an approximate top-to-north minimum displacement of 60–100 km. The associated mylonite zone is most broadly developed in the footwall. The immediate hanging wall was only marginally involved in the mylonitization process, as can be demonstrated from the contrasting thorium signatures of mylonites derived from the upper amphibolite facies footwall and the granulite facies hanging wall protoliths. Thermal weakening cannot account for such an inverse deformation gradient, as syn-deformational P–T estimates for the Petermann Orogeny in the hanging wall and footwall from the same locality are very similar. The distribution of pseudotachylytes, which acted as preferred nucleation sites for shear deformation, also cannot provide an explanation, since these fault rocks are especially prevalent in the immediate hanging wall. The most likely reason for the inverted deformation gradient across the Woodroffe Thrust is water-assisted weakening due to the increased, but still limited, presence of aqueous fluids in the footwall. We also establish a qualitative increase in the abundance of fluids in the footwall along an approx. 60 km long section in the direction of thrusting, together with a slight decrease in the temperature of mylonitization (ca. 100 °C). These changes in ambient conditions are accompanied by a 6-fold decrease in thickness (from ca. 600 to 100 m) of the Woodroffe Thrust mylonitic zone.

Geophysical evidence for lower continental crustal earthquakes in almost all collisional orogens is in conflict with the widely accepted notion that rocks, under high grade conditions, should flow rather than fracture. Pseudotachylytes are remnants of frictional melts generated during seismic slip and can therefore be used as an indicator of former seismogenic fault zones. The Fregon Subdomain in Central Australia was deformed under dry sub-eclogitic conditions of 600–700 °C and 1.0–1.2 GPa during the intracontinental Petermann Orogeny (ca. 550 Ma) and contains abundant pseudotachylyte. These pseudotachylytes are commonly foliated, recrystallized, and cross-cut by other pseudotachylytes, reflecting repeated generation during ongoing ductile deformation. This interplay is interpreted as evidence for repeated seismic brittle failure and post- to inter-seismic creep under dry lower-crustal conditions. Thermodynamic modelling of the pseudotachylyte bulk composition gives the same PT conditions of shearing as in surrounding mylonites. We conclude that pseudotachylytes in the Fregon Subdomain are a direct analogue of current seismicity in dry lower continental crust.

The complexity and heterogeneity of human water use over large spatial areas and decadal timescales can impede the understanding of hydrological change, particularly in regions with sparse monitoring of the water cycle. In the Arkavathy watershed in southern India, surface water inflows to major reservoirs decreased over a 40-year period during which urbanization, groundwater depletion, modification of the river network, and changes in agricultural practices also occurred. These multiple, interacting drivers combined with limited hydrological monitoring make attribution of the causes of diminishing water resources in the watershed challenging and impede effective policy responses. To mitigate these challenges, we developed a novel, spatially distributed dataset to understand hydrological change by characterizing the residual trends in surface water extent that remain after controlling for precipitation variations and comparing the trends with historical land use maps to assess human drivers of change. Using an automated classification approach with subpixel unmixing, we classified water extent in nearly 1700 man-made lakes, or tanks, in Landsat images from 1973 to 2010. The classification results compared well with a reference dataset of water extent of tanks (R2 = 0.95). We modeled the water extent of 42 clusters of tanks in a multiple regression on simple hydrological covariates (including precipitation) and time. Inter-annual variability in precipitation accounted for 63 % of the predicted variability in water extent. However, precipitation did not exhibit statistically significant trends in any part of the watershed. After controlling for precipitation variability, we found statistically significant temporal trends in water extent, both positive and negative, in 13 of the clusters. Based on a water balance argument, we inferred that these trends likely reflect a non-stationary relationship between precipitation and watershed runoff. Independently of precipitation, water extent increased in a region downstream of Bangalore, likely due to increased urban effluents, and declined in the northern portion of the Arkavathy. Comparison of the drying trends with land use indicated that they were most strongly associated with irrigated agriculture, sourced almost exclusively by groundwater. This suggests that groundwater abstraction was a major driver of hydrological change in this watershed. Disaggregating the watershed-scale hydrological response via remote sensing of surface water bodies over multiple decades yielded a spatially resolved characterization of hydrological change in an otherwise poorly monitored watershed. This approach presents an opportunity to understand hydrological change in heavily managed watersheds where surface water bodies integrate upstream runoff and can be delineated using satellite imagery.

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Due to their high energy requirements, high-yielding dairy cows receive high-grain diets. This commonly jeopardises their gastrointestinal health by causing subacute ruminal acidosis (SARA) and hindgut acidosis. These disorders can disrupt nutrient utilisations, impair the functionalities of gastrointestinal microbiota, and reduce the absorptive and barrier capacities of gastrointestinal epithelia. They can also trigger inflammatory responses. The symptoms of SARA are not only due to a depressed rumen pH. Hence, the diagnosis of this disorder based solely on reticulo-rumen pH values is inaccurate. An accurate diagnosis requires a combination of clinical examinations of cows, including blood, milk, urine and faeces parameters, as well as analyses of herd management and feed quality, including the dietary contents of NDF, starch and physical effective NDF. Grain-induced SARA increases acidity and shifts availabilities of substrates for microorganisms in the reticulo-rumen and hindgut and can result in a dysbiotic microbiota that are characterised by low richness, diversity and functionality. Also, amylolytic microorganisms become more dominant at the expense of proteolytic and fibrolytic ones. Opportunistic microorganisms can take advantage of newly available niches, which, combined with reduced functionalities of epithelia, can contribute to an overall reduction in nutrient utilisation and increasing endotoxins and pathogens in digesta and faeces. The reduced barrier function of epithelia increases translocation of these endotoxins and other immunogenic compounds out of the digestive tract, which may be the cause of inflammations. This needs to be confirmed by determining the toxicity of these compounds. Cows differ in their susceptibility to poor gastrointestinal health, due to variations in genetics, feeding history, diet adaptation, gastrointestinal microbiota, metabolic adaptation, stress and infections. These differences may also offer opportunities for the management of gastrointestinal health. Strategies to prevent SARA include balancing the diet for physical effective fibre, non-fibre carbohydrates and starch, managing the different fractions of non-fibre carbohydrates, and consideration of the type and processing of grain and forage digestibility. Gastrointestinal health disorders due to high grain feeding may be attenuated by a variety of feed supplements and additives, including buffers, antibiotics, probiotics/direct fed microbials and yeast products. However, the efficacy of strategies to prevent these disorders must be improved. This requires a better understanding of the mechanisms through which these strategies affect the functionality of gastrointestinal microbiota and epithelia, and the immunity, inflammation and ‘gastrointestinal-health robustness’ of cows. More representative models to induce SARA are also needed.

Water planning decisions are only as good as our ability to explain historical trends and make reasonable predictions of future water availability. But predicting water availability can be a challenge in rapidly growing regions, where human modifications of land and waterscapes are changing the hydrologic system. Yet, many regions of the world lack the long-term hydrologic monitoring records needed to understand past changes and predict future trends. We investigated this "predictions under change" problem in the data-scarce Thippagondanahalli (TG Halli) catchment of the Arkavathy sub-basin in southern India. Inflows into TG Halli reservoir have declined sharply since the 1970s. The causes of the drying are poorly understood, resulting in misdirected or counter-productive management responses. Five plausible hypotheses that could explain the decline were tested using data from field surveys and secondary sources: (1) changes in rainfall amount, seasonality and intensity; (2) increases in temperature; (3) groundwater extraction; (4) expansion of eucalyptus plantations; and (5) fragmentation of the river channel. Our results suggest that groundwater pumping, expansion of eucalyptus plantations and, to a lesser extent, channel fragmentation are much more likely to have caused the decline in surface flows in the TG Halli catchment than changing climate. The multiple-hypothesis approach presents a systematic way to quantify the relative contributions of proximate anthropogenic and climate drivers to hydrological change. The approach not only makes a meaningful contribution to the policy debate but also helps prioritize and design future research. The approach is a first step to conducting use-inspired socio-hydrologic research in a watershed.

Both endothelial dysfunction and arterial stiffness are considered as independent predictors of cardiovascular mortality, but their interrelationship has been poorly explored. Therefore we evaluated the relationship between endothelial function and pulse wave velocity (PWV) in essential hypertensive patients with (DM+) or without (DM-) diabetes mellitus, on chronic pharmacological treatment. 51 DM+ patients and 51 DM- patients matched for age, gender and BP were included. Applanation tonometry (Sphygmocor®) was used to determine aortic (carotid to femoral) PWV. Brachial artery endothelium-dependent flow-mediated dilation (FMD), and endothelium-independent dilation by 25 μg sublingual glycerol trinitrate (GTN) were assessed by high resolution ultrasound and computerized edge detection system. In DM+ PWV was higher (9.9±1.8 vs 8.4±1.4m/s, p=0.0001) and FMD was lower (3.1±1.7 vs 6.3±3.5, p

Cellulite is the result of complex physiological changes of the subcutaneous fat layer and of microcirculation, clinically manifesting as orange peel skin especially in women and involving thighs, buttocks, and abdomen. An adequate water intake has been suggested to be helpful in controlling the development and worsening of the disease. An open randomized controlled study has been performed to evaluate modification induced by an adequate diet associated to low-sodium or high-sodium water intake on some clinical features of patients affected with mild to moderate cellulite. Non-invasive instrumental investigations (Bioelectrical Impedance Analysis (BIA), thermography and skin echography) were used before and after dietary treatment. A significant improvement of the disease, in terms of weight loss, cutaneous microcirculation and reduction of subcutaneous fat layer, was observed in the group of patients who underwent low-sodium water intake. An adequate dietary treatment associated to a low-sodium water intake is able to efficiently controll some biological and clinical parameters of mild to moderate cellulite.

Improving the quality of obstetric care is an urgent priority in developing countries, where maternal mortality remains high. The feasibility of criterion-based clinical audit of the assessment and management of five major obstetric complications is being studied in Ghana and Jamaica. In order to establish case definitions and clinical audit criteria, a systematic review of the literature was followed by three expert panel meetings. A modified nominal group technique was used to develop consensus among experts on a final set of case definitions and criteria. Five main obstetric complications were selected and definitions were agreed. The literature review led to the identification of 67 criteria, and the panel meetings resulted in the modification and approval of 37 of these for the next stage of audit. Criterion-based audit, which has been devised and tested primarily in industrialized countries, can be adapted and applied where resources are poorer. The selection of audit criteria for such settings requires local expert opinion to be considered in addition to research evidence, so as to ensure that the criteria are realistic in relation to conditions in the field. Practical methods for achieving this are described in the present paper.

BACKGROUND:Non-union affects up to 10% of fractures and is associated with substantial morbidity. There is currently no single effective therapy for the treatment or prevention of non-union. Potential treatments are currently selected for clinical trials based on results from limited animal studies, with no attempt to compare results between therapies to determine which have the greatest potential to treat non-union. AIM:The aim of this systematic review was to define the range of therapies under investigation at the preclinical stage for the prevention or treatment of fracture non-union. Additionally, through meta-analysis, it aimed to identify the most promising therapies for progression to clinical investigation. METHODS:MEDLINE and Embase were searched from 1St January 2004 to 10th April 2017 for controlled trials evaluating an intervention to prevent or treat fracture non-union. Data regarding the model used, study intervention and outcome measures were extracted, and risk of bias assessed. RESULTS:Of 5,171 records identified, 197 papers describing 204 therapies were included. Of these, the majority were only evaluated once (179/204, 88%), with chitosan tested most commonly (6/204, 3%). Substantial variation existed in model design, length of survival and duration of treatment, with results poorly reported. These factors, as well as a lack of consistently used objective outcome measures, precluded meta-analysis. CONCLUSION:This review highlights the variability and poor methodological reporting of current non-union research. The authors call for a consensus on the standardisation of animal models investigating non-union, and suggest journals apply stringent criteria when considering animal work for publication.