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431 results on '"Eggert P"'

1. The effects of a digital lifestyle intervention in patients with hypertension: Results of a pilot randomized controlled trial

Author: Alina Wildenauer, Leonie Franziska Maurer, Laurin Rötzer, Torsten Eggert, and Christoph Schöbel
Subjects: blood pressure, digital health application, digital intervention, hypertension, lifestyle intervention, self‐management, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract In this pilot study, the authors investigated the preliminary effectiveness of the digital lifestyle intervention, actensio (mementor DE GmbH), in treating arterial hypertension. Adults with arterial hypertension were randomly assigned to an intervention group (actensio + standard care) or a control group (waiting list + standard care) in a 1:1 ratio. Primary and secondary endpoints were assessed at baseline (t0) and 3 months post‐randomization (t1). The primary endpoint was average systolic blood pressure, measured at home for 1 week. Secondary endpoints included patient engagement (measured using the “patient activation measure”; PAM‐13), average diastolic blood pressure, and heart rate. All endpoints were analyzed using ANCOVA models, following an intention‐to‐treat approach, while adjusting for baseline values. Missing data were estimated using multiple imputation models. A total of N = 102 participants (f = 59, age = 52.94 ± 9.01) were randomized to either the intervention (IG; N = 52) or the control group (CG; N = 50), of which N = 80 completed the blood pressure diary, and N = 81 the PAM‐13 at t1. Between‐group comparisons showed an average group difference in systolic blood pressure of −5.06 mm Hg (95% CI = −8.71 to −1.41, p = .013) between the intervention group (M = 137.37 ± 10.13) and the control group (M = 142.35 ± 11.23). Average group difference for patient engagement was 3.35 points with a trend towards statistical significance (95% CI = −018 to 6.89, p = .064), favoring the intervention group (MIG = 79.38 ± 9.44 vs. MCG = 75.45 ± 10.62). There were no group differences in diastolic blood pressure (−1.78 mm Hg; 95% CI = −4.50 to 0.95, p = .402) and heart rate (−0.684; 95% CI = −3.73 to 2.36, p = 0.683). The results of the present pilot study confirm the preliminary effectiveness of the digital lifestyle intervention, actensio, in reducing high blood pressure in patients with hypertension.
Published: 2024
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2. Forschung mit Grundschüler:innen

Author: Franziska Koschei, Lena Schmidt, Susanne Eggert, Andreas Dertinger, Michaela Kramer, and Rudolf Kammerl
Subjects: medienpädagogische Forschung, digitale Bildung, partizipative Forschung, Grundschule, Primarschule, Special aspects of education, LC8-6691
Abstract: Der Beitrag widmet sich der Frage, wie multiperspektivisch, akteur:innenorientiert sowie partizipativ mit Kindern geforscht werden kann und worin der Mehrwert dieses Vorgehens besteht. Dies wird anhand eines Forschungsprojekts erläutert. Im Verbundprojekt «DiBiGa – Zukunftsperspektiven für die Digitale Bildung im Grundschulalter» beschäftigt sich ein Forschungsteam der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) und des JFF – Institut für Medienpädagogik mit der Frage, wie Digitale Bildung mit Blick auf Kinder im Grundschulalter künftig gestaltet sein soll. Ausgangspunkt sind die Erfahrungen der an Digitaler Bildung beteiligten Akteur:innen mit dem pandemiebedingten Distance-Schooling. Im Projekt wurden die Perspektiven der verschiedenen Akteur:innen aus den Bereichen Schule (Schulleiter:innen, Vertreter:innen, Expert:innen auf schuladministrativer Ebene) sowie Familie (Kinder, Eltern und Erziehungsberechtigte, Fachkräfte aus der Sozialpädagogischen Familienhilfe) erhoben und aufeinander bezogen (Multiperspektivität). Dabei wurde darauf geachtet, dass sich die Ausgestaltung der Erhebung an den jeweiligen Voraussetzungen der interviewten Personengruppen orientierte (Akteur:innenorientierung). Darüber hinaus wurden Handlungsempfehlungen für die Weiterentwicklung der Digitalen Bildung im Grundschulalter gemeinsam mit den zentralen Akteur:innen erarbeitet (Partizipativität). Der Fokus des Artikels liegt auf der Statusgruppe der Kinder und ihren Perspektiven auf das Thema. Abschliessend werden die Limitationen des gewählten Forschungsvorgehens diskutiert und eingeordnet.
Published: 2024
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3. Diminutiver på -ke i danske personnavne

Author: Birgit Eggert
Subjects: historical socio-onomastics, migration, diminutives in -ke, name geography, medieval name use, Philology. Linguistics, P1-1091
Abstract: This study shows how during the Middle Ages, names in Denmark originally formed using the diminutive -ke are more frequent in male names than female names. In contrast, -ke was far more frequent in female names during the 18th century, compared to male names. Perhaps by this time names ending in -ke had begun to be perceived as feminine names. Furthermore, geographical distribution had changed considerably by the 18th century, and the majority of the name bearers were found in rural areas and, not mainly in market towns and Southern Jutland as was the case in the Middle Ages. This may indicate that the medieval use of names ending in -ke among German migrants had integrated with local Danish naming and had moved from towns to the rural population.
Published: 2024
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4. The Other Site of Rhabdomyosarcoma

Author: Leonie Kern, Anton Henssen, Angelika Eggert, and Monika Scheer
Subjects: adult sarcoma, age, age‐spanning, lymph nodes, other site, pediatric sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: ABSTRACT Background Rhabdomyosarcoma (RMS) is a rare malignant soft tissue sarcoma (STS), accounting for almost 50% of pediatric STSs. Due to its heterogeneity, RMS presents challenges in diagnosis and treatment, with prognosis varying depending on multiple factors. Tumors localized in the other site (OTH)—including the paraspinal, perianal, thoracic, abdominal, pelvic, and perineal regions—are generally classified as unfavorable. This study assesses the clinical features and prognoses of RMS in OTH locations depending on its site of origin. Methods An explorative analysis of RMS cases from the SEER 17 database 2000–2020 was conducted. Patients of all ages with histologically confirmed RMS as primary malignant disease classified under OTH, were included. OTH was categorized in four granular site classifications. Overall survival (OS) and disease‐specific survival (DSS) were analyzed using Kaplan–Meier estimators. Factors independently influencing survival, including a site classification model presented in this study, were identified through Cox regression analysis. Results Out of 4168 patients with RMS, 990 cases of RMS with the OTH site met the inclusion criteria. The median age was 16 years. The predominant histological subtypes were embryonal (33.0%) and alveolar (25.5%). Most tumors were ≥ 5 cm (median 9 cm) and located primarily in the pelvic region (41.5%). The 3‐, 5‐, and 10‐year OS rates were 45.4% ± 3.332 (95% CI), 40.7 ± 3.332, and 38.6% ± 3.332, respectively, while DSS rates were 43.3% ± 3.136 (95% CI), 38.3% ± 3.136, and 35.1% ± 3.332. In the multivariate analysis age, histological type, site in a granular categorization, stage, regional lymph node examination, and regional lymph node involvement (pathologically proven) were independently associated with survival. Through both univariate and multivariate analyses, an OTH favorable group could be established. The OTH favorable group consists of the anal region, gallbladder and biliary tract, and breast. Conclusion RMS in OTH shows significant differences in prognosis, putting the current categorization as unfavorable into question and making a more detailed classification necessary. Furthermore, pathological regional lymph node assessment is specifically in the OTH localization recommended.
Published: 2024
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5. Search for central exclusive production of top quark pairs in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV with tagged protons

Author: The CMS collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, J. Li, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, G. Kole, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, S. Elgammal, A. Ellithi Kamel, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, M. Voutilainen, S. Bharthuar, E. Brücken, J. Havukainen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M. m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, P. Jarry, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, J. Rembser, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E. C. Chabert, C. Collard, D. Darej, U. Goerlach, C. Grimault, A.-C. Le Bihan, P. Van Hove, S. Beauceron, C. Bernet, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, V. Sordini, L. Torterotot, M. Vander Donckt, P. Verdier, S. Viret, G. Adamov, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, M. Erdmann, P. Fackeldey, D. Fasanella, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, M. y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mondal, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, H. Reithler, A. Schmidt, S. C. Schuler, A. Sharma, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, O. Hlushchenko, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, P. Asmuss, S. Baxter, M. Bayatmakou, O. Behnke, A. Bermúdez Martínez, S. Bhattacharya, A. A. Bin Anuar, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, L. Didukh, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, A. Grohsjean, V. Guglielmi, M. Guthoff, A. Jafari, N. Z. Jomhari, B. Kaech, A. Kasem, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A. B. Meyer, G. Milella, M. Mormile, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, A. Saibel, M. Savitskyi, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R. E. Sosa Ricardo, D. Stafford, N. Tonon, M. Van De Klundert, F. Vazzoler, A. Ventura Barroso, R. Walsh, D. Walter, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, R. Aggleton, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, K. De Leo, M. Eich, K. El Morabit, F. Feindt, A. Fröhlich, C. Garbers, E. Garutti, M. Hajheidari, J. Haller, A. Hinzmann, H. R. Jabusch, G. Kasieczka, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, M. Rieger, O. Rieger, P. Schleper, M. Schröder, J. Schwandt, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, J. Bechtel, S. Brommer, M. Burkart, E. Butz, R. Caspart, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, J. O. Gosewisch, A. Gottmann, F. Hartmann, M. Horzela, U. Husemann, P. Keicher, M. Klute, R. Koppenhöfer, S. Maier, S. Mitra, Th. Müller, M. Neukum, G. Quast, K. Rabbertz, J. Rauser, D. Savoiu, M. Schnepf, D. Seith, I. Shvetsov, H. J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R. F. Von Cube, M. Wassmer, M. Weber, S. Wieland, R. Wolf, S. Wozniewski, S. Wunsch, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Stakia, M. Diamantopoulou, D. Karasavvas, P. Kontaxakis, A. Manousakis-Katsikakis, A. Panagiotou, I. Papavergou, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, E. Vourliotis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, K. Kousouris, I. Papakrivopoulos, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Csanád, K. Farkas, M. M. A. Gadallah, S. Lökös, P. Major, K. Mandal, G. Pásztor, A. J. Rádl, O. Surányi, G. I. Veres, M. Bartók, G. Bencze, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, N. Beni, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, D. Teyssier, P. Raics, B. Ujvari, T. Csorgo, T. Novak, J. Babbar, S. Bansal, S. B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, R. Gupta, A. Kaur, H. Kaur, M. Kaur, S. Kumar, P. Kumari, M. Meena, K. Sandeep, T. Sheokand, J. B. Singh, A. Singla, A. K. Virdi, A. Ahmed, A. Bhardwaj, B. C. Choudhary, M. Gola, S. Keshri, A. Kumar, M. Naimuddin, P. Priyanka, K. Ranjan, S. Saumya, A. Shah, S. Baradia, S. Barman, D. Bhowmik, S. Dutta, B. Gomber, M. Maity, P. Palit, P. K. Rout, G. Saha, B. Sahu, S. Sarkar, P. K. Behera, S. C. Behera, P. Kalbhor, J. R. Komaragiri, D. Kumar, A. Muhammad, L. Panwar, R. Pradhan, P. R. Pujahari, A. K. Sikdar, P. C. Tiwari, S. Verma, K. Naskar, T. Aziz, I. Das, S. Dugad, M. Kumar, G. B. Mohanty, P. Suryadevara, S. Banerjee, R. Chudasama, M. Guchait, S. Karmakar, G. Majumder, K. Mazumdar, A. Thachayath, S. Bahinipati, A. K. Das, C. Kar, P. Mal, T. Mishra, V. K. Muraleedharan Nair Bindhu, A. Nayak, P. Saha, N. Sur, S. K. Swain, D. Vats, A. Alpana, S. Dube, B. Kansal, A. Laha, S. Pandey, A. Rastogi, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S. M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, C. Aruta, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, F. Errico, L. Fiore, G. Iaselli, M. Ince, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, D. Ramos, A. Ranieri, G. Selvaggi, L. Silvestris, F. M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, P. Giacomelli, L. Giommi, C. Grandi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F. L. Navarria, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, R. Seidita, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, F. Ferro, R. Mulargia, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M. E. Dinardo, P. Dini, S. Gennai, A. Ghezzi, P. Govoni, L. Guzzi, M. T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B. S. Pinolini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A. O. M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, P. Azzi, N. Bacchetta, M. Biasotto, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, L. Ciano, T. Dorigo, S. Fantinel, U. Gasparini, G. Grosso, L. Layer, E. Lusiani, M. Margoni, A. T. Meneguzzo, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, P. Asenov, G. M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Piccinelli, M. Presilla, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, V. Bertacchi, R. Bhattacharya, L. Bianchini, T. Boccali, D. Bruschini, R. Castaldi, M. A. Ciocci, V. D’Amante, R. Dell’Orso, M. R. Di Domenico, S. Donato, A. Giassi, F. Ligabue, E. Manca, G. Mandorli, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, S. Parolia, G. Ramirez-Sanchez, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, N. Shafiei, P. Spagnolo, R. Tenchini, G. Tonelli, A. Venturi, P. G. Verdini, P. Barria, M. Campana, F. Cavallari, D. Del Re, E. Di Marco, M. Diemoz, E. 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Kovalskyi, J. Krupa, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G. S. F. Stephans, Z. Wang, B. Wyslouch, R. M. Chatterjee, B. Crossman, A. Evans, J. Hiltbrand, Sh. Jain, B. M. Joshi, C. Kapsiak, M. Krohn, Y. Kubota, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, L. M. Cremaldi, K. Bloom, M. Bryson, D. R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, I. Kravchenko, I. Reed, J. E. Siado, G. R. Snow, W. Tabb, A. Wightman, F. Yan, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Lidrych, G. Madigan, B. Marzocchi, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, T. Gunter, K. A. Hahn, Y. Liu, N. Odell, M. H. Schmitt, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L. S. Durkin, B. Francis, C. Hill, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, B. Bonham, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, A. Kalogeropoulos, G. Kopp, S. Kwan, D. Lange, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Norberg, A. S. Bakshi, V. E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, M. Decaro, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, B. P. Padley, R. Redjimi, J. Rotter, W. Shi, E. Yigitbasi, L. Zhang, X. Zuo, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, B. Tannenwald, P. E. Karchin, N. Poudyal, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, D. Budkouski, V. Bunichev, O. Bychkova, M. Chadeeva, V. Chekhovsky, A. Dermenev, T. Dimova, I. Dremin, M. Dubinin, L. Dudko, V. Epshteyn, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, E. Kuznetsova, A. Lanev, P. Levchenko, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Okhotnikov, I. Ovtin, V. Palichik, P. Parygin, V. Perelygin, M. Perfilov, G. Pivovarov, V. Popov, E. Popova, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, A. Stepennov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, P. Volkov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, The TOTEM collaboration, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, C. Baldenegro Barrera, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F. S. Cafagna, M. G. Catanesi, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, T. Isidori, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M. V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, K. Misan, T. Naaranoja, F. Nemes, H. Niewiadomski, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, S. Ozkorucuklu, P. Palazzi, V. Passaro, Z. Peroutka, O. Potok, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, C. Taylor, E. Tcherniaev, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, and J. Zich
Subjects: Hadron-Hadron Scattering, Top Physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for the central exclusive production of top quark-antiquark pairs ( t t ¯ $$ \textrm{t}\overline{\textrm{t}} $$ ) is performed for the first time using proton-tagged events in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 29.4 fb −1. The t t ¯ $$ \textrm{t}\overline{\textrm{t}} $$ decay products are reconstructed using the central CMS detector, while forward protons are measured in the CMS-TOTEM precision proton spectrometer. An observed (expected) upper bound on the production cross section of 0.59 (1.14) pb is set at 95% confidence level, for collisions of protons with fractional momentum losses between 2 and 20%.
Published: 2024
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6. Environmental, economic, and social sustainability in aquaculture: the aquaculture performance indicators

Author: Taryn M. Garlock, Frank Asche, James L. Anderson, Håkan Eggert, Thomas M. Anderson, Bin Che, Carlos A. Chávez, Jingjie Chu, Nnaemeka Chukwuone, Madan M. Dey, Kevin Fitzsimmons, Jimely Flores, Jordi Guillen, Ganesh Kumar, Lijun Liu, Ignacio Llorente, Ly Nguyen, Rasmus Nielsen, Ruth B. M. Pincinato, Pratheesh O. Sudhakaran, Byela Tibesigwa, and Ragnar Tveteras
Subjects: Science
Abstract: Abstract Aquaculture is a rapidly growing food production technology, but there are significant concerns related to its environmental impact and adverse social effects. We examine aquaculture outcomes in a three pillars of sustainability framework by analyzing data collected using the Aquaculture Performance Indicators. Using this approach, comparable data has been collected for 57 aquaculture systems worldwide on 88 metrics that measure social, economic, or environmental outcomes. We first examine the relationships among the three pillars of sustainability and then analyze performance in the three pillars by technology and species. The results show that economic, social, and environmental outcomes are, on average, mutually reinforced in global aquaculture systems. However, the analysis also shows significant variation in the degree of sustainability in different aquaculture systems, and weak performance of some production systems in some dimensions provides opportunity for innovative policy measures and investment to further align sustainability objectives.
Published: 2024
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7. Dissonant Landscapes: Music, Nature, and the Performance of Iceland Tore Størvold Middletown Wesleyan University Press 2023

Author: Arnar Eggert Thoroddsen
Subjects: Music, M1-5000
Published: 2024
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8. Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity

Author: Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, and Kerstin Haase
Subjects: CP: Cancer, Biology (General), QH301-705.5
Abstract: Summary: Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid oncogene amplification. While ecDNA-mediated oncogene amplification is linked to poor prognosis in various cancers, the effects of ecDNA copy-number heterogeneity on intermediate phenotypes are poorly understood. Here, we leverage DNA and RNA sequencing from the same single cells in cell lines and neuroblastoma patients to investigate these effects. By analyzing ecDNA amplicon structures, we reveal extensive intercellular ecDNA copy-number heterogeneity. We also provide direct evidence of how this heterogeneity influences the expression of cargo genes, including MYCN and its downstream targets, and the overall transcriptional state of neuroblastoma cells. Our findings highlight the role of ecDNA copy number in promoting rapid adaptability of cellular states within tumors, underscoring the need for ecDNA-specific treatment strategies to address tumor formation and adaptation.
Published: 2024
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9. Lower incidence of grade II-IV acute Graft-versus-Host-Disease in pediatric patients recovering with high Vδ2+ T cells after allogeneic stem cell transplantation with unmanipulated bone marrow grafts: a prospective single-center cohort study

Author: Thilo Müller, Lina Alasfar, Friederike Preuß, Lisa Zimmermann, Mathias Streitz, Patrick Hundsdörfer, Angelika Eggert, Johannes Schulte, Arend von Stackelberg, and Lena Oevermann
Subjects: pediatric stem cell transplantation, allogeneic stem cell transplantation, gamma delta (γδ) T cells, immune reconstitution, transplant immunobiology, Graft-versus-Host Disease (GVHD), Immunologic diseases. Allergy, RC581-607
Abstract: Gamma delta (γδ) T cells represent a minor fraction of human T cell repertoire but play an important role in mediating anti-infectious and anti-tumorous effects in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We performed a prospective study to analyze the effect of different transplant modalities on immune reconstitution of γδ T cells and subsets. CD3, CD4 and CD8 T cells were analyzed in parallel. Secondly, we examined the impact of γδ T cell reconstitution on clinical outcomes including acute Graft-versus-Host-Disease (aGvHD) and viral infections. Our cohort includes 49 pediatric patients who received unmanipulated bone marrow grafts from matched unrelated (MUD) or matched related (MRD) donors. The cohort includes patients with malignant as well as non-malignant diseases. Cell counts were measured using flow cytometry at 15, 30, 60, 100, 180 and 240 days after transplantation. Cells were stained for CD3, CD4, CD8, CD45, TCRαβ, TCRγδ, TCRVδ1, TCRVδ2, HLA-DR and combinations. Patients with a MRD showed significantly higher Vδ2+ T cells than those with MUD at timepoints +30, +60, +100 (p
Published: 2024
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10. EEG tensor decomposition delineates neurophysiological principles underlying conflict-modulated action restraint and action cancellation

Author: Negin Gholamipourbarogh, Elena Eggert, Alexander Münchau, Christian Frings, and Christian Beste
Subjects: Conflict monitoring, Response inhibition, EEG, Neurophysiology, Tensor decomposition, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Executive functions are essential for adaptive behavior. One executive function is the so-called ‘interference control’ or conflict monitoring another one is inhibitory control (i.e., action restraint and action cancelation). Recent evidence suggests an interplay of these processes, which is conceptually relevant given that newer conceptual frameworks imply that nominally different action/response control processes are explainable by a small set of cognitive and neurophysiological processes. The existence of such overarching neural principles has as yet not directly been examined. In the current study, we therefore use EEG tensor decomposition methods, to look into possible common neurophysiological signatures underlying conflict-modulated action restraint and action cancelation as mechanism underlying response inhibition. We show how conflicts differentially modulate action restraint and action cancelation processes and delineate common and distinct neural processes underlying this interplay. Concerning the spatial information modulations are similar in terms of an importance of processes reflected by parieto-occipital electrodes, suggesting that attentional selection processes play a role. Especially theta and alpha activity seem to play important roles. The data also show that tensor decomposition is sensitive to the manner of task implementation, thereby suggesting that switch probability/transitional probabilities should be taken into consideration when choosing tensor decomposition as analysis method. The study provides a blueprint of how to use tensor decomposition methods to delineate common and distinct neural mechanisms underlying action control functions using EEG data.
Published: 2024
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11. Questionnaire-based study of COVID-19 vaccination induced headache: evidence of clusters of adverse events

Author: Qiao Zhou, Thomas Eggert, Ana Zhelyazkova, Alexander Choukér, Kristina Adorjan, and Andreas Straube
Subjects: Headache, Covid-19 vaccination, Adverse events, Side effects, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Background The adverse events (AEs) after a Coronavirus disease 2019 (Covid-19) Pfizer-Biotech mRNA vaccination present a medical and epidemiological issue of increasing interest. Headache is the most frequent neurological adverse effect and generally the third most common adverse event after a Covid-19 vaccination, but only a few studies focus on the link between headache and other AEs after vaccination. This study aims to investigate the correlation between headaches and Covid-19 vaccination, as well as the possible links between headaches and other AEs after Covid-19 vaccination, thereby helping the management of AEs and avoiding further occurrences. Methods This study is based on a published questionnaire survey of 1,402 healthcare workers. Our study focused on the 5 questions including 12 AEs and headaches extracted from the questionnaire post the first and second Covid-19 vaccination. The severity of the 12 AEs and headaches could be classified by the participants on a five-step scale: “Not at all”, “Little”, “Average”, “Quite”, and “Very” (abbreviated as “N”, “L”, “A”, “Q”, “V”). We used the Bowker test to study the comparison of headache severity, indicated on a 5-point Likert scale between the first and second vaccinations. We applied an ordinal logistic regression to the 5 categories with headache severity serving as the dependent variable and the ratings of the other 12 AEs serving as the independent variable to further explore to what extent the severity of the 12 AEs is associated with the severity of headaches. Receiver Operating Characteristic (ROC) analysis was conducted to evaluate the predictive value of the ratings of the 12 AEs to headache severity. Results We found that participants rated their headaches as more severe after the second vaccination, and participants who reported experiencing fatigue, flu-like symptoms, pain at the injection site, known tension-type headache, fever, dizziness/balance problems and known migraine are associated with headache symptoms. Conclusions There are clusters of headache-associated AEs post Covid-19 vaccination. The association of various AEs with headaches may be due to similar causative mechanisms.
Published: 2024
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12. Corticosteroid injection prior to surgery had no effect on 2-year outcomes following arthroscopic rotator cuff repair

Author: Justin T. Smith, MD, Stephan G. Pill, MD, MSPT, Kailey A. Eggert, BS, Calleigh G. Brignull, BS, Kyle J. Adams, MS, Douglas J. Wyland, MD, Stefan J. Tolan, MD, Charles A. Thigpen, PhD, PT, ATC, and Michael J. Kissenberth, MD
Subjects: Outcomes, Injections, Rotator cuff tears, Corticosteroid, Complications, Repair, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935
Abstract: Background: Corticosteroid injections (CSIs) can be an effective nonsurgical treatment for patients with rotator cuff tears. Recent large database studies have raised concern that CSI may result in a higher reoperation rate, increased infection risk, and worse outcome after arthroscopic rotator cuff repair (ARCR). The purpose of this study was to evaluate the reoperation rate, incidence of postoperative infection, and two-year outcomes of patients undergoing ARCR with and without the use of preoperative CSI. Methods: An institutional database generated from fellowship-trained orthopedic sports surgeons was retrospectively queried for patients who underwent ARCR with a minimum of two-year follow-up. Inclusion criteria consisted of 1) primary full-thickness rotator cuff tear and 2) preoperative and minimum two-year patient-reported outcome measures (PROMs). Of the 219 patients identified, 134 patients had preoperative subacromial CSI administered within one year of ARCR. Reoperation rate, number of injections, Visual Analog Scale, American Shoulder and Elbow Surgeons Score, Single Assessment Numeric Evaluation, and Veterans Rand 12-Item Health Survey Physical Component Score/Mental Component Score were compared between groups at six months, one year, and two years. Chi-square and t-tests were used to compare baseline differences, postoperative infections, and reoperations. A repeated measures Analyses of Covariance was used to measure differences between PROMs at each time point. Simple Analyses of Covariance were used for the two-year sub-analyses for patients receiving CSI within 90 days of surgery and if multiple preoperative CSI had been given (α ≤ 0.05). Results: There were no significant demographic differences between groups (P > .05). Preoperative use of subacromial CSI within one year prior to ARCR did not increase reoperation rate (P = .85) or impact PROMs at any timepoint. There were two reoperations during the study period in the CSI group (2 lysis of adhesions). No infections occurred in either cohort. No differences were found if injections were performed within 90 days of surgery or if more than one CSI was administered within the year prior to surgery (P > .05). Conclusion: Our results show that preoperative CSI prior to primary ARCR did not increase risk of reoperation, infection, or influence PROMs with a minimum follow-up of 2 years.
Published: 2024
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13. Aging and growth outside the comfort zone: the case of alien fire-bellied toads in France

Author: D. Cogălniceanu, F. Stănescu, and C. Eggert
Subjects: Amphibia, Bombina bombina, introduced, invasive potential, survival rate, Zoology, QL1-991
Abstract: Understanding why some small populations succeed while others fail to establish in novel environments has major implications in applied fields such as in situ species conservation and reintroductions. Species introductions outside their native range provide excellent opportunities to address such topic, since invasions usually start with small populations. We studied the life-history strategy of a population of the fire-bellied toad (Bombina bombina) introduced in France, outside the natural range of the species, to estimate its population demographic potential. The introduced population showed a fast life history strategy, with early sexual maturation at 2 years of age, a relatively short life-span (3.1 years in females and 2.3 in males, with a maximum age of 5 years), and survival rates similar to those of populations from its native range. The population presents the characteristics for becoming invasive and might pose a threat to the native yellow-bellied toad (B. variegata) populations nearby through hybridization, competition and as potential vector of pathogens and parasites. Its spread should be closely monitored and additional introductions avoided to limit its potential negative impact.
Published: 2024
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14. Remotely supervised spirometry versus laboratory-based spirometry during the COVID-19 pandemic: a retrospective analysis

Author: Łukasz Kołtowski, Mikołaj Basza, Wojciech Bojanowicz, Piotr Dąbrowiecki, Mateusz Soliński, Katarzyna Górska, Piotr Korczyński, and Lauren E. Eggert
Subjects: Spirometry, Pulmonary function tests, Telemedicine, COVID-19, Diseases of the respiratory system, RC705-779
Abstract: Abstract Background The COVID-19 pandemic has constrained access to spirometry, and the inherent risk of infectious transmission during aerosol-generating procedures has necessitated the rapid development of Remotely Supervised Spirometry (RSS). This innovative approach enables patients to perform spirometry tests at home, using a mobile connected spirometer, all under the real-time supervision of a technician through an online audio or video call. Methods In this retrospective study, we examined the quality of RSS in comparison to conventional Laboratory-based Spirometry (LS), using the same device and technician. Our sample included 242 patients, with 129 undergoing RSS and 113 participating in LS. The RSS group comprised 51 females (39.5%) with a median age of 37 years (range: 13–76 years). The LS group included 63 females (55.8%) with a median age of 36 years (range: 12–80 years). Results When comparing the RSS group to the LS group, the percentage of accurate Forced Expiratory Volume in one second (FEV1) measurements was 78% (n = 101) vs. 86% (n = 97), p = 0.177; for Forced Vital Capacity (FVC) it was 77% (n = 99) vs. 82% (n = 93), p = 0.365; and for both FEV1 and FVC, it was 75% (n = 97) vs. 81% (n = 92), p = 0.312, respectively. Conclusions Our findings demonstrate no significant difference in the quality of spirometry testing between RSS and LS, a result that held true across all age groups, including patients aged over 65 years. The principal advantages of remote spirometry include improved access to pulmonary function tests, reduced infectious risk to curtail disease spread, and enhanced convenience for patients.
Published: 2024
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15. Contemporary Practice of Anemia Treatment Among Dialysis Patients in the United States

Author: Eric D. Weinhandl, William Eggert, Yunji Hwang, David T. Gilbertson, and Jeffrey Petersen
Subjects: anemia, erythropoiesis-stimulating agent, hemodialysis, hemoglobin, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Introduction: The treatment of anemia is a major activity in the care of patients undergoing maintenance hemodialysis (HD). The comparative effectiveness of new pharmacologic treatments, relative to erythropoiesis-stimulating agents (ESAs), should be anticipated on the bases of controlled trials and current practice. We describe the contemporary practice of anemia treatment in a national cohort of patients undergoing maintenance HD. Methods: We analyzed the United States Renal Data System (USRDS) data to identify adult patients undergoing in-facility HD in 2016 to 2019. Using the Consolidated Renal Operations in a Web-Enabled Network (CROWNWeb) dataset, we identified hemoglobin and ESA utilization (agent and cumulative dose) during each patient-month, as well as intravenous (IV) iron utilization, ferritin, and transferrin saturation. We compared ESA dosing during the study era to dosing in the Normal Hematocrit Cardiac Trial (NHCT), conducted in the 1990s. We assessed ESA hyporesponsiveness by estimating the prevalence of the following: (i) high erythropoietin resistance index (ERI) and (ii) either 3 or 6 consecutive months with hemoglobin
Published: 2023
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16. Patient-individual 3D-printing of drugs within a machine-learning-assisted closed-loop medication management – Design and first results of a feasibility study

Author: Claudia Langebrake, Karl Gottfried, Adrin Dadkhah, Jan Eggert, Tobias Gutowski, Moritz Rosch, Nils Schönbeck, Christopher Gundler, Sylvia Nürnberg, Frank Ückert, and Michael Baehr
Subjects: 3D printing of drugs, Precision dosing, Medication management, Hospital pharmacy, Machine-learning, Smart wearables, Medicine
Abstract: 3D-printing of medicines is an innovative manufacturing method that is characterised by a high degree of digitalisation and automation and enables patient-specific care. Its integration into routine healthcare processes currently fails mainly due to the requirements of a digital environment. Our hospital was the first hospital in Europe to introduce a fully comprehensive patient record in 2011 and to digitalise and automate the drug supply process.The aim of our study is to evaluate the integration of a machine-learning assisted 3D printing of medicines into the already existing, fully digital medication process of the hospital (closed-loop medication management, CLMM). Here, the design of this feasibility study and first results of subprojects are presented.First, a suitable and clinically relevant active ingredient (levodopa/carbidopa) was identified in a multi-step approach by an interdisciplinary panel of experts using defined evaluation criteria, taking into account galenic, clinical and machine learning aspects. In the next step, a galenic formulation using a suitable printing technology for manufacturing a drug according to pharmaceutical quality criteria in different dosages is to be developed and to be evaluated for compliance with quality criteria according to the European Pharmacopoeia. Furthermore, an IT concept was developed and adapted to the hospital's current IT infrastructure. Likewise, a machine learning algorithm is to be developed to determine the optimal dose for each individual patient using data from smart wearable devices. For this purpose, a clinical trial was set up as a proof-of-principle study for the use of wearables to detect and grade clinical symptoms from Parkinson’s Disease. Finally, the process is to be connected to the digital medication process of the hospital taking into account regulatory requirements.Thus, this interdisciplinary feasibility study will provide important insights into the possibilities of integrating patient-specific 3D printing of medicines into everyday clinical practice in the hospital.
Published: 2023
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17. Extended X-ray absorption fine structure of dynamically-compressed copper up to 1 terapascal

Author: H. Sio, A. Krygier, D. G. Braun, R. E. Rudd, S. A. Bonev, F. Coppari, M. Millot, D. E. Fratanduono, N. Bhandarkar, M. Bitter, D. K. Bradley, P. C. Efthimion, J. H. Eggert, L. Gao, K. W. Hill, R. Hood, W. Hsing, N. Izumi, G. Kemp, B. Kozioziemski, O. L. Landen, K. Le Galloudec, T. E. Lockard, A. Mackinnon, J. M. McNaney, N. Ose, H.-S. Park, B. A. Remington, M. B. Schneider, S. Stoupin, D. B. Thorn, S. Vonhof, C. J. Wu, and Y. Ping
Subjects: Science
Abstract: Abstract Large laser facilities have recently enabled material characterization at the pressures of Earth and Super-Earth cores. However, the temperature of the compressed materials has been largely unknown, or solely relied on models and simulations, due to lack of diagnostics under these challenging conditions. Here, we report on temperature, density, pressure, and local structure of copper determined from extended x-ray absorption fine structure and velocimetry up to 1 Terapascal. These results nearly double the highest pressure at which extended x-ray absorption fine structure has been reported in any material. In this work, the copper temperature is unexpectedly found to be much higher than predicted when adjacent to diamond layer(s), demonstrating the important influence of the sample environment on the thermal state of materials; this effect may introduce additional temperature uncertainties in some previous experiments using diamond and provides new guidance for future experimental design.
Published: 2023
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18. BIBLIOTECA ESCOLAR NA EDUCAÇÃO INFANTIL: REVISÃO SISTEMÁTICA DE LITERATURA

Author: Marina Moreira and Gisela Eggert-Steindel
Subjects: biblioteca escolar, educação infantil, revisão sistemática de literatura, Language and Literature, Education (General), L7-991
Abstract: O objetivo deste artigo é mapear produções científicas, nacionais e internacionais, sobre a Biblioteca Escolar nas instituições de Educação Infantil produzidas entre os anos de 1996 e 2021. Neste artigo, se realizou uma Revisão Sistemática de Literatura nas seguintes bases de dados: Catálogo de teses e dissertação da CAPES; BRAPCI; Portal de periódicos da CAPES; Web of Science; EBSCO; e SCOPUS. Foram selecionados para compor o corpus textual desta revisão artigos, dissertações e teses que resultaram em 27 publicações. A Literatura indica o valor intrínseco da Biblioteca Escolar para a criança desde a mais tenra idade. Os trabalhos encontrados apontaram para as potencialidades da Biblioteca Escolar no desenvolvimento de práticas que favorecem as habilidades de leitura e escrita na Educação Infantil, considerando os conceitos de alfabetização e letramento na primeira infância. Outro destaque encontrado na literatura refere-se à importância da família para o sucesso das atividades feitas pela biblioteca, sua participação deve ser ativa e consciente em prol do desenvolvimento da criança.
Published: 2023
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19. F4ESS – a framework for interdisciplinary data-driven earth system science

Author: Doris Dransch, Daniel Eggert, and Mike Sips
Subjects: earth system science, interdisciplinary research, scientific workflows, integration, Mathematical geography. Cartography, GA1-1776
Abstract: Earth system science is an interdisciplinary effort to understand the fundamentals and interactions of environmental processes. Interdisciplinary research is challenging since it demands the integration of scientific schemes and practices from different research fields into a collaborative work environment. This paper introduces the framework F4ESS that supports this integration. F4ESS provides methods and technologies that facilitate the development of integrative work environments for Earth system science. F4ESS enables scientists a) to outline structured and summarized descriptions of scientific procedures to facilitate communication and synthesis, b) to combine a large variety of distributed data analysis software into seamless data analysis chains and workflows, c) to visually combine and interactively explore the manifold spatiotemporal data and results to support understanding and knowledge creation. The F4ESS methods and technologies are generic and can be applied in various scientific fields. We discuss F4ESS in the context of the interdisciplinary investigation of flood events.
Published: 2023
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20. Simultaneous bright- and dark-field X-ray microscopy at X-ray free electron lasers

Author: Leora E. Dresselhaus-Marais, Bernard Kozioziemski, Theodor S. Holstad, Trygve Magnus Ræder, Matthew Seaberg, Daewoong Nam, Sangsoo Kim, Sean Breckling, Sungwook Choi, Matthieu Chollet, Philip K. Cook, Eric Folsom, Eric Galtier, Arnulfo Gonzalez, Tais Gorkhover, Serge Guillet, Kristoffer Haldrup, Marylesa Howard, Kento Katagiri, Seonghan Kim, Sunam Kim, Sungwon Kim, Hyunjung Kim, Erik Bergbäck Knudsen, Stephan Kuschel, Hae Ja Lee, Chuanlong Lin, R. Stewart McWilliams, Bob Nagler, Martin Meedom Nielsen, Norimasa Ozaki, Dayeeta Pal, Ricardo Pablo Pedro, Alison M. Saunders, Frank Schoofs, Toshimori Sekine, Hugh Simons, Tim van Driel, Bihan Wang, Wenge Yang, Can Yildirim, Henning Friis Poulsen, and Jon H. Eggert
Subjects: Medicine, Science
Abstract: Abstract The structures, strain fields, and defect distributions in solid materials underlie the mechanical and physical properties across numerous applications. Many modern microstructural microscopy tools characterize crystal grains, domains and defects required to map lattice distortions or deformation, but are limited to studies of the (near) surface. Generally speaking, such tools cannot probe the structural dynamics in a way that is representative of bulk behavior. Synchrotron X-ray diffraction based imaging has long mapped the deeply embedded structural elements, and with enhanced resolution, dark field X-ray microscopy (DFXM) can now map those features with the requisite nm-resolution. However, these techniques still suffer from the required integration times due to limitations from the source and optics. This work extends DFXM to X-ray free electron lasers, showing how the $$10^{12}$$ 10 12 photons per pulse available at these sources offer structural characterization down to 100 fs resolution (orders of magnitude faster than current synchrotron images). We introduce the XFEL DFXM setup with simultaneous bright field microscopy to probe density changes within the same volume. This work presents a comprehensive guide to the multi-modal ultrafast high-resolution X-ray microscope that we constructed and tested at two XFELs, and shows initial data demonstrating two timing strategies to study associated reversible or irreversible lattice dynamics.
Published: 2023
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21. Enhancement of Heme-Oxygenase 1 in the Injured Peripheral Nerve Following Sulforaphane Administration Fosters Regeneration via Proliferation and Maintenance of Repair Schwann Cells

Author: Fabian Szepanowski, Jaqueline Zipfel, Rebecca D. Szepanowski, Bianca Eggert, Nail-Mert Güner, Leon-Phillip Szepanowski, Christoph Kleinschnitz, Anne K. Mausberg, and Mark Stettner
Subjects: HO-1, Nrf2, nerve injury, nerve crush, sulforaphane, broccoli extract, Therapeutics. Pharmacology, RM1-950
Abstract: Nuclear erythroid 2-related factor 2 (Nrf2) and its downstream effector heme oxygenase 1 (HO-1) are commonly activated in response to cellular stresses. The elevated expression of HO-1 has been associated with markedly accelerated peripheral nerve regeneration. This study aimed to evaluate the impact of a naturally occurring dietary Nrf2/HO-1 activator—sulforaphane (SFN)—on regeneration in a murine sciatic nerve crush model. The beneficial safety profile of SFN has been thoroughly investigated and confirmed several times. Here, SFN was administered daily, starting immediately after C57BL/6 mice were subjected to sciatic nerve crush injury. Injured sciatic nerves were excised at various time points post injury for molecular, immunohistochemical and morphometric analyses. Moreover, functional assessment was performed by grip strength analysis and electrophysiology. Following SFN treatment, the early response to injury includes a modulation of autophagic pathways and marked upregulation of Nrf2/HO-1 expression. This enhancement of HO-1 expression was maintained throughout the regeneration phase and accompanied by a significant increase in repair Schwann cells. In these cells, elevated proliferation rates were observed. Significant improvements in grip strength test performance, nerve conduction velocity and remyelination were also noted following SFN treatment. Collectively, SFN modulates cytoprotective and autophagic pathways in the injured nerve, increasing the number of repair Schwann cells and contributing to effective nerve regeneration. Given the availability of SFN as a nutritional supplement, this compound might constitute a novel regenerative approach with broad patient accessibility and further studies on this topic are warranted.
Published: 2024
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22. Flight Attitude Estimation with Radar for Remote Sensing Applications

Author: Christoph Weber, Marius Eggert, and Thomas Udelhoven
Subjects: radar sensor, flight attitude estimation, drone, UAV, remote sensing, Chemical technology, TP1-1185
Abstract: Unmanned aerial vehicles (UAVs) and radar technology have benefitted from breakthroughs in recent decades. Both technologies have found applications independently of each other, but together, they also unlock new possibilities, especially for remote sensing applications. One of the key factors for a remote sensing system is the estimation of the flight attitude. Despite the advancements, accurate attitude estimation remains a significant challenge, particularly due to the limitations of a conventional Inertial Measurement Unit (IMU). Because these sensors may suffer from issues such as drifting, additional effort is required to obtain a stable attitude. Against that background, this study introduces a novel methodology for making an attitude estimation using radar data. Herein, we present a drone measurement system and detail its calculation process. We also demonstrate our results using three flight scenarios and outline the limitations of the approach. The results show that the roll and pitch angles can be calculated using the radar data, and we conclude that the findings of this research will help to improve the flight attitude estimation of remote sensing flights with a radar sensor.
Published: 2024
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23. Speeding up squeezing with a periodically driven Dicke model

Author: Jarrod T. Reilly, Simon B. Jäger, John Drew Wilson, John Cooper, Sebastian Eggert, and Murray J. Holland
Subjects: Physics, QC1-999
Abstract: We present a simple and effective method to create highly entangled spin states on a faster timescale than that of the commonly employed one-axis twisting (OAT) model. We demonstrate that by periodically driving the Dicke Hamiltonian at a resonance frequency, the system effectively becomes a two-axis countertwisting Hamiltonian, which is known to quickly create Heisenberg limit scaled entangled states. For these states we show that simple quadrature measurements can saturate the ultimate precision limit for parameter estimation determined by the quantum Cramér-Rao bound. An example experimental realization of the periodically driven scheme is discussed with the potential to quickly generate momentum entanglement in a recently described experimental vertical cavity system. We analyze effects of collective dissipation in this vertical cavity system and find that our squeezing protocol can be more robust than the previous realization of OAT.
Published: 2024
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24. Author Correction: Environmental, economic, and social sustainability in aquaculture: the aquaculture performance indicators

Author: Taryn M. Garlock, Frank Asche, James L. Anderson, Håkan Eggert, Thomas M. Anderson, Bin Che, Carlos A. Chávez, Jingjie Chu, Nnaemeka Chukwuone, Madan M. Dey, Kevin Fitzsimmons, Jimely Flores, Jordi Guillen, Ganesh Kumar, Lijun Liu, Ignacio Llorente, Ly Nguyen, Rasmus Nielsen, Ruth B. M. Pincinato, Pratheesh O. Sudhakaran, Byela Tibesigwa, and Ragnar Tveteras
Subjects: Science
Published: 2024
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25. 4. Nurture vs. Nature? PRS Residency Programs Influence on Career Specialization

Author: Gina Eggert, Bhagvat Maheta, BS, Mitchell Hanson, BS, Chandler Hinson, Kometh Thawanyarat, Rahim Nazerali, Clifford C. Sheckter, MD, and Paige Fox
Subjects: Surgery, RD1-811
Published: 2024
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26. A search for new physics in central exclusive production using the missing mass technique with the CMS detector and the CMS-TOTEM precision proton spectrometer

Author: A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Kou, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, Y. Assran, S. Elgammal, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, M. Voutilainen, S. Bharthuar, E. Brücken, J. Havukainen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, P. Jarry, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E. C. Chabert, C. Collard, D. Darej, U. Goerlach, C. Grimault, A.-C. Le Bihan, P. Van Hove, S. Beauceron, C. Bernet, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, L. Torterotot, M. Vander Donckt, P. Verdier, S. Viret, I. Bagaturia, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, M. Erdmann, P. Fackeldey, D. Fasanella, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mondal, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, H. Reithler, A. Schmidt, S. C. Schuler, A. Sharma, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, O. Hlushchenko, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, P. Asmuss, S. Baxter, M. Bayatmakou, O. Behnke, A. Bermúdez Martínez, S. Bhattacharya, A. A. Bin Anuar, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, L. Didukh, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, A. Grohsjean, V. Guglielmi, M. Guthoff, A. Jafari, N. Z. Jomhari, B. Kaech, A. Kasem, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A. B. Meyer, G. Milella, M. Mormile, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, A. Saibel, M. Savitskyi, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R. E. Sosa Ricardo, D. Stafford, N. Tonon, M. Van De Klundert, F. Vazzoler, A. Ventura Barroso, R. Walsh, D. Walter, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, K. De Leo, M. Eich, K. El Morabit, F. Feindt, A. Fröhlich, C. Garbers, E. Garutti, M. Hajheidari, J. Haller, A. Hinzmann, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, T. Loesche, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, M. Rieger, O. Rieger, D. Savoiu, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, J. Bechtel, S. Brommer, M. Burkart, E. Butz, R. Caspart, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, J. O. Gosewisch, A. Gottmann, F. Hartmann, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, S. Maier, S. Mitra, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, J. Rauser, M. Schnepf, D. Seith, I. Shvetsov, H. J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R. F. Von Cube, M. Wassmer, S. Wieland, R. Wolf, S. Wozniewski, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Stakia, M. Diamantopoulou, D. Karasavvas, P. Kontaxakis, A. Manousakis-Katsikakis, A. Panagiotou, I. Papavergou, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, K. Kousouris, I. Papakrivopoulos, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, K. Farkas, M. M. A. Gadallah, S. Lökös, P. Major, K. Mandal, G. Pásztor, A. J. Rádl, O. Surányi, G. I. Veres, M. Bartók, G. Bencze, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, N. Beni, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, D. Teyssier, P. Raics, B. Ujvari, J. Babbar, S. Bansal, S. B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, R. Gupta, A. Kaur, H. Kaur, M. Kaur, S. Kumar, P. Kumari, M. Meena, K. Sandeep, T. Sheokand, J. B. Singh, A. Singla, A. K. Virdi, A. Ahmed, A. Bhardwaj, B. C. Choudhary, M. Gola, A. Kumar, M. Naimuddin, P. Priyanka, K. Ranjan, S. Saumya, A. Shah, S. Baradia, S. Barman, D. Bhowmik, S. Dutta, B. Gomber, M. Maity, P. Palit, G. Saha, B. Sahu, S. Sarkar, P. K. Behera, S. C. Behera, P. Kalbhor, J. R. Komaragiri, D. Kumar, A. Muhammad, L. Panwar, R. Pradhan, P. R. Pujahari, A. K. Sikdar, P. C. Tiwari, S. Verma, K. Naskar, T. Aziz, I. Das, S. Dugad, M. Kumar, G. B. Mohanty, P. Suryadevara, S. Banerjee, R. Chudasama, M. Guchait, S. Karmakar, G. Majumder, K. Mazumdar, A. Thachayath, S. Bahinipati, C. Kar, P. Mal, T. Mishra, V. K. Muraleedharan Nair Bindhu, A. Nayak, P. Saha, S. K. Swain, D. Vats, A. Alpana, S. Dube, B. 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McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L. S. Durkin, B. Francis, C. Hill, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, A. Kalogeropoulos, G. Kopp, S. Kwan, D. Lange, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Norberg, A. S. Bakshi, V. E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, M. Decaro, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, B. P. Padley, R. Redjimi, J. Rotter, W. Shi, E. Yigitbasi, L. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, B. Tannenwald, P. E. Karchin, N. Poudyal, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, A. Dermenev, T. Dimova, I. Dremin, M. Dubinin, L. Dudko, V. Epshteyn, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, E. Kuznetsova, A. Lanev, P. Levchenko, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, A. Oskin, I. Ovtin, V. Palichik, P. Parygin, V. Perelygin, S. Petrushanko, G. Pivovarov, S. Polikarpov, V. Popov, E. Popova, O. Radchenko, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, A. Stepennov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F.S. Cafagna, M.G. Catanesi, M. Csanád, T. Csörgő, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M.V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, K. Misan, T. Naaranoja, F. Nemes, H. Niewiadomski, T. Novák, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, P. Palazzi, V. Passaro, Z. Peroutka, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, J. Sziklai, C. Taylor, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, J. Zich, and CMS and TOTEM Collaborations
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A generic search is presented for the associated production of a Z boson or a photon with an additional unspecified massive particle X, $${\textrm{pp}}\rightarrow {\textrm{pp}} +{{\textrm{Z}}}/\upgamma +{{\textrm{X}}} $$ pp → pp + Z / γ + X , in proton-tagged events from proton–proton collisions at $$\sqrt{s}=13\, \textrm{TeV}$$ s = 13 TeV , recorded in 2017 with the CMS detector and the CMS-TOTEM precision proton spectrometer. The missing mass spectrum is analysed in the 600–1600 GeV range and a fit is performed to search for possible deviations from the background expectation. No significant excess in data with respect to the background predictions has been observed. Model-independent upper limits on the visible production cross section of $${\textrm{pp}}\rightarrow {\textrm{pp}} +{{\textrm{Z}}}/\upgamma +{{\textrm{X}}} $$ pp → pp + Z / γ + X are set.
Published: 2023
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27. Sociodemographic and work-related differences in teachers’ attitude towards and perceived stress from emergency remote teaching during the COVID-19 pandemic

Author: Kristin Kalo, Clemens Koestner, Theresa Dicks, Viktoria Eggert, Till Beutel, Carolina Zähme, Stephan Letzel, and Pavel Dietz
Subjects: Medicine, Science
Abstract: Abstract The aim was to investigate the attitude towards and perceived stress from emergency remote teaching (ERT) among teachers during the COVID-19 pandemic. A Germany-wide online survey was conducted among teachers from all school types in March 2021. Data from 31,089 teachers entered analysis. ANOVAs or Welch’s t-tests with post-hoc analyses were performed to determine sociodemographic and work-related group differences in teachers’ attitude towards and perceived stress from ERT. The mean attitude towards ERT was 3.47 (± .84) out of 5 and the mean perceived stress was 5.03 (± .62) out of 6. Regarding the attitude towards ERT, we revealed significant differences for gender, age groups, number of children, occupational group, school management membership, and employment status (p
Published: 2023
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28. APP family member dimeric complexes are formed predominantly in synaptic compartments

Author: Sandra Schilling, Alexander August, Mathieu Meleux, Carolin Conradt, Luisa M. Tremmel, Sandra Teigler, Virginie Adam, Ulrike C. Müller, Edward H. Koo, Stefan Kins, and Simone Eggert
Subjects: Alzheimer’s disease, Amyloid precursor protein, APLP1, APLP2, Dimerization, Synaptosomes, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436
Abstract: Abstract Background The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and heterotypic dimers and exhibit overlapping functions. Results We investigated complex formation of the APP family members via two inducible dimerization systems, the FKBP-rapamycin based dimerization as well as cysteine induced dimerization, combined with co-immunoprecipitations and Blue Native (BN) gel analyses. Within the APP family, APLP1 shows the highest degree of dimerization and high molecular weight (HMW) complex formation. Interestingly, only about 20% of APP is dimerized in cultured cells whereas up to 50% of APP is dimerized in mouse brains, independent of age and splice forms. Furthermore, we could show that dimerized APP originates mostly from neurons and is enriched in synaptosomes. Finally, BN gel analysis of human cortex samples shows a significant decrease of APP dimers in AD patients compared to controls. Conclusions Together, we suggest that loss of full-length APP dimers might correlate with loss of synapses in the process of AD.
Published: 2023
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29. Search for high-mass exclusive γγ → WW and γγ → ZZ production in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: The CMS collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, G. Kole, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, A. A. Abdelalim, E. Salama, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, M. Voutilainen, S. Bharthuar, E. Brücken, J. Havukainen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M. m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, P. Jarry, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. 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Cooperstein, D. Diaz, J. Duarte, R. Gerosa, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, B. V. Sathia Narayanan, V. Sharma, M. Tadel, F. Würthwein, Y. Xiang, A. Yagil, N. Amin, C. Campagnari, M. Citron, G. Collura, A. Dorsett, V. Dutta, J. Incandela, M. Kilpatrick, A. J. Li, P. Masterson, H. Mei, M. Oshiro, M. Quinnan, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, P. Siddireddy, D. Stuart, S. Wang, A. Bornheim, O. Cerri, I. Dutta, J. M. Lawhorn, N. Lu, J. Mao, H. B. Newman, T. Q. Nguyen, M. Spiropulu, J. R. Vlimant, C. Wang, S. Xie, R. Y. Zhu, J. Alison, S. An, M. B. Andrews, P. Bryant, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J. P. Cumalat, W. T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, F. Marini, R. Patel, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K. A. Ulmer, S. R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D. J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J. R. Patterson, D. Quach, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, L. A. T. Bauerdick, D. Berry, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, K. F. Di Petrillo, J. Dickinson, V. D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, S. Grünendahl, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, H. A. Weber, I. Zoi, P. Avery, D. Bourilkov, L. Cadamuro, V. Cherepanov, R. D. Field, D. Guerrero, M. Kim, E. Koenig, J. Konigsberg, A. Korytov, K. H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, U. Shi, Z. Wu, T. Adams, A. Askew, R. Habibullah, V. Hagopian, T. Kolberg, G. Martinez, H. Prosper, C. Schiber, O. Viazlo, R. Yohay, J. Zhang, M. M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, F. Yumiceva, M. R. Adams, H. Becerril Gonzalez, R. Cavanaugh, S. Dittmer, O. Evdokimov, C. E. Gerber, D. J. Hofman, D. S. Lemos, A. H. Merrit, C. Mills, G. Oh, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, K. Dilsiz, L. Emediato, R. P. Gandrajula, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, O. Amram, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, J. Roskes, S. Sekhar, M. Swartz, T. Á. Vámi, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, S. Khalil, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, C. Rogan, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, S. Duric, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, T. Mitchell, A. Modak, K. Nam, J. Natoli, D. Roy, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, L. Wang, K. Wong, D. Abercrombie, W. Busza, I. A. Cali, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, M. Hu, D. Kovalskyi, J. Krupa, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G. S. F. Stephans, Z. Wang, B. Wyslouch, R. M. Chatterjee, B. Crossman, A. Evans, J. Hiltbrand, Sh. Jain, B. M. Joshi, C. Kapsiak, M. Krohn, Y. Kubota, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, L. M. Cremaldi, K. Bloom, M. Bryson, D. R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, I. Kravchenko, I. Reed, J. E. Siado, G. R. Snow, W. Tabb, A. Wightman, F. Yan, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K. A. Hahn, Y. Liu, N. Odell, M. H. Schmitt, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L. S. Durkin, B. Francis, C. Hill, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, A. Kalogeropoulos, G. Kopp, S. Kwan, D. Lange, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Norberg, A. S. Bakshi, V. E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, M. Decaro, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, B. P. Padley, R. Redjimi, J. Rotter, W. Shi, E. Yigitbasi, L. Zhang, X. Zuo, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, B. Tannenwald, P. E. Karchin, N. Poudyal, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, D. Budkouski, V. Bunichev, O. Bychkova, M. Chadeeva, V. Chekhovsky, A. Dermenev, T. Dimova, I. Dremin, M. Dubinin, L. Dudko, V. Epshteyn, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, E. Kuznetsova, A. Lanev, P. Levchenko, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Okhotnikov, I. Ovtin, V. Palichik, P. Parygin, V. Perelygin, M. Perfilov, G. Pivovarov, V. Popov, E. Popova, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, A. Stepennov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, The TOTEM collaboration, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F. S. Cafagna, M. G. Catanesi, M. Csanád, T. Csörgő, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, T. Isidori, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M. V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, T. Naaranoja, F. Nemes, H. Niewiadomski, T. Novák, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, P. Palazzi, V. Passaro, Z. Peroutka, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, J. Sziklai, C. Taylor, E. Tcherniaev, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, J. Zich, and K. Zielinski
Subjects: Forward Physics, Hadron-Hadron Scattering, Vector Boson Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search is performed for exclusive high-mass γγ → WW and γγ → ZZ production in proton-proton collisions using intact forward protons reconstructed in near-beam detectors, with both weak bosons decaying into boosted and merged jets. The analysis is based on a sample of proton-proton collisions collected by the CMS and TOTEM experiments at s $$ \sqrt{s} $$ = 13 TeV, corresponding to an integrated luminosity of 100 fb −1. No excess above the standard model background prediction is observed, and upper limits are set on the pp → pWWp and pp → pZZp cross sections in a fiducial region defined by the diboson invariant mass m(VV) > 1 TeV (with V = W, Z) and proton fractional momentum loss 0.04 < ξ < 0.20. The results are interpreted as new limits on dimension-6 and dimension-8 anomalous quartic gauge couplings.
Published: 2023
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30. Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Author: Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, and Johannes H. Schulte
Subjects: Science
Abstract: Abstract Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome sequencing in 104 primary neuroblastomas covering all risk groups. We demonstrate that MYCN amplification, which defines a subset of high-risk cases, causes globally suppressed circRNA biogenesis directly dependent on the DHX9 RNA helicase. We detect similar mechanisms in shaping circRNA expression in the pediatric cancer medulloblastoma implying a general MYCN effect. Comparisons to other cancers identify 25 circRNAs that are specifically upregulated in neuroblastoma, including circARID1A. Transcribed from the ARID1A tumor suppressor gene, circARID1A promotes cell growth and survival, mediated by direct interaction with the KHSRP RNA-binding protein. Our study highlights the importance of MYCN regulating circRNAs in cancer and identifies molecular mechanisms, which explain their contribution to neuroblastoma pathogenesis.
Published: 2023
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31. A MHz X-ray diffraction set-up for dynamic compression experiments in the diamond anvil cell

Author: Rachel J. Husband, Cornelius Strohm, Karen Appel, Orianna B. Ball, Richard Briggs, Johannes Buchen, Valerio Cerantola, Stella Chariton, Amy L. Coleman, Hyunchae Cynn, Dana Dattelbaum, Anand Dwivedi, Jon H. Eggert, Lars Ehm, William J. Evans, Konstantin Glazyrin, Alexander F. Goncharov, Heinz Graafsma, Alex Howard, Larissa Huston, Trevor M. Hutchinson, Huijeong Hwang, Sony Jacob, Johannes Kaa, Jaeyong Kim, Minseob Kim, Egor Koemets, Zuzana Konôpková, Falko Langenhorst, Torsten Laurus, Xinyang Li, Jona Mainberger, Hauke Marquardt, Emma E. McBride, Christopher McGuire, James D. McHardy, Malcolm I. McMahon, R. Stewart McWilliams, Alba S. J. Méndez, Anshuman Mondal, Guillaume Morard, Earl F. O'Bannon, Christoph Otzen, Charles M. Pépin, Vitali B. Prakapenka, Clemens Prescher, Thomas R. Preston, Ronald Redmer, Michael Roeper, Carmen Sanchez-Valle, Dean Smith, Raymond F. Smith, Daniel Sneed, Sergio Speziale, Tobias Spitzbart, Stephan Stern, Blake T. Sturtevant, Jolanta Sztuk-Dambietz, Peter Talkovski, Nenad Velisavljevic, Cara Vennari, Zhongyan Wu, Choong-Shik Yoo, Ulf Zastrau, Zsolt Jenei, and Hanns-Peter Liermann
Subjects: extreme conditions science, x-ray free-electron lasers, diamond anvil cells, dynamic compression, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798, Crystallography, QD901-999
Abstract: An experimental platform for dynamic diamond anvil cell (dDAC) research has been developed at the High Energy Density (HED) Instrument at the European X-ray Free Electron Laser (European XFEL). Advantage was taken of the high repetition rate of the European XFEL (up to 4.5 MHz) to collect pulse-resolved MHz X-ray diffraction data from samples as they are dynamically compressed at intermediate strain rates (≤103 s−1), where up to 352 diffraction images can be collected from a single pulse train. The set-up employs piezo-driven dDACs capable of compressing samples in ≥340 µs, compatible with the maximum length of the pulse train (550 µs). Results from rapid compression experiments on a wide range of sample systems with different X-ray scattering powers are presented. A maximum compression rate of 87 TPa s−1 was observed during the fast compression of Au, while a strain rate of ∼1100 s−1 was achieved during the rapid compression of N2 at 23 TPa s−1.
Published: 2023
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32. Nonplanar effects in simulations of laser-driven ejecta microjet experiments

Author: J. A. K. Horwitz, Y. Sun, J. Pino, B. E. Morgan, K. K. Mackay, F. M. Najjar, S. J. Ali, J. H. Eggert, Y. Ping, H.-S. Park, and A. M. Saunders
Subjects: Physics, QC1-999
Abstract: Recent experiments of laser-driven ejecta microjets performed at OMEGA 60 reveal tortuous jets whereby the jets appear to deviate from their initial trajectory as they travel in vacuum. To understand these data, we perform two dimensional numerical simulations, considering different target thicknesses, pressures, and models of the drive conditions. In particular, modeling the finite laser spot size appears essential in reproducing qualitatively the non-planar shock observed in the experiment. Simulations capture jet deflection by accounting for a slight misalignment of the laser pointing with respect to the groove axis along with spatial variation of the laser pulse intensity. The principal physical mechanism appears to be that lateral momentum is imparted by release waves arising from the non-planar drive. The induced off-axis velocity is small in comparison to the jet axial velocity but integrates into a pronounced deflection over the course of the experiment. The analysis of jet axial and lateral mass distributions is found to be reproduced reasonably by the simulations. Simulated radiographs are in qualitative agreement with the experiments, though their differences point to potential shortcomings in modeling strictly three-dimensional experiments using two-dimensional hydrodynamic simulations. The simple analysis is able to explain part of the observed discrepancy in simulated vs experimental jet masses.
Published: 2024
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33. The Spirit of Fieldwork? Navigating Alcohol Consumption, Abstinence and Religious Positionalities in Social Sciences Research

Author: Jennifer Philippa Eggert and Seb Rumsby
Subjects: alcohol, Autoethnography, fieldwork, Lebanon, religion, religious positionality, Social sciences (General), H1-99
Abstract: In recent years, debates on researcher positionality have increasingly gained traction in academic circles. However, despite this increased focus on questions evolving around the impact of the researcher's presence on the research process and outcome, there are still issues that scholars have tended to avoid, such as the effect of alcohol on the research process. While existing publications contain some discussion of various aspects related to researchers navigating alcohol consumption during fieldwork, they do not touch on the role of religion—a striking absence considering the prevalence of religious reasons for abstinence. In this article, we therefore build on existing literature by discussing two case studies focused on the experiences of religious researchers with alcohol that help complicate our understanding of the role of alcohol consumption and abstinence during fieldwork. Using a collaborative autoethnographic approach and drawing on our fieldwork experiences as a Muslim woman in Lebanon and a Christian man in Vietnam, we discuss how religion affects rapport and insider/outsider dynamics during fieldwork. We conclude with recommendations on how academic institutions can better support students and staff members (regardless of religious identity or lack thereof) when it comes to navigating alcohol consumption during fieldwork and beyond.
Published: 2024
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34. Rethinking ecoanxiety through environmental moral distress: an ethics reflection

Author: Nicola Banwell and Nadja Eggert
Subjects: Moral distress, Moral injury, Ethics of care, Ecofeminism, Ecological emotions, Climate change, Public aspects of medicine, RA1-1270, Meteorology. Climatology, QC851-999
Abstract: Humanity is currently confronted with simultaneous complex environmental crises of unprecedented scale. These include, but are not limited to, the ongoing sixth mass extinction and the depletion of biodiversity, and ongoing anthropogenic greenhouse gas emissions which are causing changes in the climate that humanity has never before witnessed. As these ecological crises continue to progress, there is increasing recognition of the impact this has on mental health. Within this context, the notion of ecoanxiety has gained traction, primarily from the perspective of psychology, with the view to elevate suffering. However, in our view, the risk of considering ecoanxiety, and other ecological emotions, solely from a medicalized perspective as a mental disorder is that it places too much responsibility on individuals, decontextualizes ecological emotions from their social and political settings, and detaches these emotions from their ethical and moral dimensions. This article proposes to reconsider ecological emotions from the perspective of moral distress. Environmental moral distress resituates ecological emotions within their social and political contexts, and sheds light on their entanglement with ethical realms that medicalized conceptions of ecoanxiety fail to recognize. We argue that responding to environmental moral distress requires a shift to an ethics of care and ecofeminist paradigm which enables us to consider ecological emotions as contextualized indicators of the experience of morally questionable actions. This approach opens the door to collective responses aiming to empower and build moral agency in the face of the shared moral and political struggles which characterize the ecological crisis.
Published: 2024
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35. Applications of the pipeline environment for visual informatics and genomics computations

Author: Genco Alex, Pierce Jonathan, Eggert Paul, Zamanyan Alen, Liu Zhizhong, Petrosyan Petros, Macciardi Fabio, Torri Federica, Dinov Ivo D, Knowles James A, Clark Andrew P, Van Horn John D, Ames Joseph, Kesselman Carl, and Toga Arthur W
Subjects: Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract: Abstract Background Contemporary informatics and genomics research require efficient, flexible and robust management of large heterogeneous data, advanced computational tools, powerful visualization, reliable hardware infrastructure, interoperability of computational resources, and detailed data and analysis-protocol provenance. The Pipeline is a client-server distributed computational environment that facilitates the visual graphical construction, execution, monitoring, validation and dissemination of advanced data analysis protocols. Results This paper reports on the applications of the LONI Pipeline environment to address two informatics challenges - graphical management of diverse genomics tools, and the interoperability of informatics software. Specifically, this manuscript presents the concrete details of deploying general informatics suites and individual software tools to new hardware infrastructures, the design, validation and execution of new visual analysis protocols via the Pipeline graphical interface, and integration of diverse informatics tools via the Pipeline eXtensible Markup Language syntax. We demonstrate each of these processes using several established informatics packages (e.g., miBLAST, EMBOSS, mrFAST, GWASS, MAQ, SAMtools, Bowtie) for basic local sequence alignment and search, molecular biology data analysis, and genome-wide association studies. These examples demonstrate the power of the Pipeline graphical workflow environment to enable integration of bioinformatics resources which provide a well-defined syntax for dynamic specification of the input/output parameters and the run-time execution controls. Conclusions The LONI Pipeline environment http://pipeline.loni.ucla.edu provides a flexible graphical infrastructure for efficient biomedical computing and distributed informatics research. The interactive Pipeline resource manager enables the utilization and interoperability of diverse types of informatics resources. The Pipeline client-server model provides computational power to a broad spectrum of informatics investigators - experienced developers and novice users, user with or without access to advanced computational-resources (e.g., Grid, data), as well as basic and translational scientists. The open development, validation and dissemination of computational networks (pipeline workflows) facilitates the sharing of knowledge, tools, protocols and best practices, and enables the unbiased validation and replication of scientific findings by the entire community.
Published: 2011
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36. Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity

Author: Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, and Simone Eggert
Subjects: Alzheimer’s disease, Amyloid precursor protein, Familial Alzheimer disease, Beta Amyloid, Trafficking, Processing, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract The amyloid precursor protein (APP) is a key player in Alzheimer`s disease (AD) and the precursor of the Aβ peptide, which is generated by consecutive cleavages of β- and γ-secretases. Familial Alzheimer’s disease (FAD) describes a hereditary subgroup of AD that represents a low percentage of AD cases with an early onset of the disease. Different APP FAD mutations are thought to have qualitatively different effects on its proteolytic conversion. However, few studies have explored the pathogenic and putative physiological differences in more detail. Here, we compared different FAD mutations, located at the β- (Swedish), α- (Flemish, Arctic, Iowa) or γ-secretase (Iberian) cleavage sites. We examined heterologous expression of APP WT and FAD mutants in non-neuronal cells and their impact on presynaptic differentiation in contacting axons of co-cultured neurons. To decipher the underlying molecular mechanism, we tested the subcellular localization, the endocytosis rate and the proteolytic processing in detail by immunoprecipitation–mass spectrometry. Interestingly, we found that only the Iberian mutation showed altered synaptogenic function. Furthermore, the APP Iowa mutant shows significantly decreased α-secretase processing which is in line with our results that APP carrying the Iowa mutation was significantly increased in early endosomes. However, most interestingly, immunoprecipitation–mass spectrometry analysis revealed that the amino acid substitutions of APP FAD mutants have a decisive impact on their processing reflected in altered Aβ profiles. Importantly, N-terminally truncated Aβ peptides starting at position 5 were detected preferentially for APP Flemish, Arctic, and Iowa mutants containing amino acid substitutions around the α-secretase cleavage site. The strongest change in the ratio of Aβ40/Aβ42 was observed for the Iberian mutation while APP Swedish showed a substantial increase in Aβ1–17 peptides. Together, our data indicate that familial AD mutations located at the α-, β-, and γ-secretase cleavage sites show considerable differences in the underlying pathogenic mechanisms.
Published: 2023
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37. Symptoms in unilateral vestibular hypofunction are associated with number of catch-up saccades and retinal error: results from the population-based KORA FF4 study

Author: Maria Aubele, Eva Grill, Thomas Eggert, Erich Schneider, Ralf Strobl, Klaus Jahn, Martin Müller, Rolf Holle, Birgit Linkohr, Margit Heier, Karl-Heinz Ladwig, and Nadine Lehnen
Subjects: video head impulse test, vHIT, catch-up saccades, unilateral vestibular hypofunction, retinal error, vestibulo-ocular reflex, Neurology. Diseases of the nervous system, RC346-429
Abstract: ObjectiveThe presence and intensity of symptoms vary in patients with unilateral vestibular hypofunction. We aimed to determine which saccadic and vestibulo-ocular reflex parameters best predict the presence of symptoms in unilateral vestibular hypofunction in order to better understand vestibular compensation and its implications for rehabilitation therapy.MethodsVideo head impulse test data were analyzed from a subpopulation of 23 symptomatic and 10 currently symptom-free participants with unilateral vestibular hypofunction, embedded in the KORA (Cooperative Health Research in the Region of Augsburg) FF4 study, the second follow-up of the KORA S4 population-based health survey (2,279 participants).ResultsA higher number of catch-up saccades, a higher percentage of covert saccades, and a larger retinal error at 200 ms after the onset of the head impulse were associated with relevant symptoms in participants with unilateral vestibular hypofunction (p = 0.028, p = 0.046, and p = 0.038, respectively). After stepwise selection, the number of catch-up saccades and retinal error at 200 ms remained in the final logistic regression model, which was significantly better than a null model (p = 0.014). Age, gender, saccade amplitude, saccade latency, and VOR gain were not predictive of the presence of symptoms.ConclusionThe accuracy of saccadic compensation seems to be crucial for the presence of symptoms in unilateral vestibular hypofunction, highlighting the role of specific gaze stabilization exercises in rehabilitation. Early saccades, mainly triggered by the vestibular system, do not seem to compensate accurately enough, resulting in a relevant retinal error and the need for more as well as more accurate catch-up saccades, probably triggered by the visual system.
Published: 2023
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38. Evaluating the Efficacy and Safety of 4% 5-Fluorouracil Cream in Patients with Actinic Keratosis: An Expert Opinion

Author: Eggert Stockfleth, Markus V. Heppt, Nathalie Bégeault, and Alain Delarue
Subjects: field cancerisation, fluorouracil, keratosis, actinic, safety, treatment efficacy, Dermatology, RL1-803
Abstract: Actinic keratosis is a lesion that develops in sun-exposed areas of the skin and is considered to be a precancerous condition or an early in situ squamous cell carcinoma. Treatment of actinic keratosis is important for reducing skin cancer risk, with treatment choice based on patient-, lesion- and treatment-related considerations. Of the topical treatments used for field-directed therapy, those containing 5-fluorouracil are among the most effective and widely prescribed. The most recently developed topical 5-fluorouracil preparation (Tolak®; Pierre Fabre, France) contains 4% 5-fluorouracil in an aqueous cream. This narrative review discusses data on 4% 5-fluorouracil cream to treat actinic keratosis, and provides the authors’ expert opinion on issues associated with it use. The effect of the cream has been evaluated in phase 2 and 3 trials of adult patients with actinic keratosis on the face, ears or scalp. These trials included patients with severe baseline disease, defined by high lesion counts and large-size treatment fields, which possibly affected the proportion of patients who were able to achieve complete clearance. Other efficacy parameters (e.g. percentage change in lesion count, ≥ 75% clearance of lesions or clinically significant changes in validated severity scales) should also be assessed to fully evaluate 4% 5-fluorouracil treatment efficacy in these patients. Nevertheless, 4% 5-fluorouracil is associated with high efficacy, a low level of recurrence and a satisfactory safety profile.
Published: 2023
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39. Impact of a booster dose on SARS-CoV2 mRNA vaccine-specific humoral-, B- and T cell immunity in pediatric stem cell transplant recipients

Author: Linda Marie Laura Thole, Laura Tóth, Vanessa Proß, Janine Siegle, Carolin Stahl, Georg Hermsdorf, Annette Knabe, Annika Winkler, Eva Schrezenmeier, Carolin Ludwig, Cornelia Eckert, Angelika Eggert, Hubert Schrezenmeier, Arne Sattler, Johannes H. Schulte, and Katja Kotsch
Subjects: SARS-CoV2, mRNA vaccination, stem cell transplantation, pediatrics, cellular immunity, humoral immunity, Immunologic diseases. Allergy, RC581-607
Abstract: Stem cell transplant recipients (SCTR) are imperiled to increased risks after SARS-CoV2 infection, supporting the need for effective vaccination strategies for this vulnerable group. With respect to pediatric patients, data on immunogenicity of SARS-CoV2 mRNA-based vaccination is limited. We therefore comprehensively examined specific humoral, B- and T cell responses in a cohort of 2-19 year old SCTR after the second and third vaccine dose. Only after booster vaccination, transplant recipients reached similar levels of vaccine-specific IgG, IgA and neutralizing antibodies against omicron variant as age-matched controls. Although frequencies of SARS-CoV2 specific B cells increased after the third dose, they were still fourfold reduced in patients compared to controls. Overall, the majority of individuals enrolled mounted SARS-CoV2 Spike protein-specific CD4+ T helper cell responses with patients showing significantly higher portions than controls after the third dose. With respect to functionality, however, SCTR were characterized by reduced frequencies of specific interferon gamma producing CD4+ T cells, along with an increase in IL-2 producers. In summary, our data identify distinct quantitative and qualitative impairments within the SARS-CoV2 vaccination specific B- and CD4+ T cell compartments. More importantly, humoral analyses highlight the need for a booster vaccination of SCTR particularly for development of neutralizing antibodies.
Published: 2023
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40. Characterization and root cause analysis of immunogenicity to pasotuxizumab (AMG 212), a prostate-specific membrane antigen-targeting bispecific T-cell engager therapy

Author: Hweixian Leong Penny, Kelly Hainline, Nathaniel Theoharis, Bin Wu, Christian Brandl, Christian Webhofer, Mason McComb, Sabine Wittemer-Rump, Gökben Koca, Sabine Stienen, Ralf C. Bargou, Horst-Dieter Hummel, Wolfgang Loidl, Carsten Grüllich, Tobias Eggert, Ben Tran, and Daniel T. Mytych
Subjects: immunogenicity, BiTE®, T cell engager, ADA, prostate cancer, Immunologic diseases. Allergy, RC581-607
Abstract: IntroductionIn oncology, anti-drug antibody (ADA) development that significantly curtails response durability has not historically risen to a level of concern. The relevance and attention ascribed to ADAs in oncology clinical studies have therefore been limited, and the extant literature on this subject scarce. In recent years, T cell engagers have gained preeminence within the prolific field of cancer immunotherapy. These drugs whose mode of action is expected to potently stimulate anti-tumor immunity, may potentially induce ADAs as an unintended corollary due to an overall augmentation of the immune response. ADA formation is therefore emerging as an important determinant in the successful clinical development of such biologics. MethodsHere we describe the immunogenicity and its impact observed to pasotuxizumab (AMG 212), a prostate-specific membrane antigen (PSMA)-targeting bispecific T cell engager (BiTE®) molecule in NCT01723475, a first-in-human (FIH), multicenter, dose-escalation study in patients with metastatic castration-resistant prostate cancer (mCRPC). To explain the disparity in ADA incidence observed between the SC and CIV arms of the study, we interrogated other patient and product-specific factors that may have explained the difference beyond the route of administration. ResultsTreatment-emergent ADAs (TE-ADA) developed in all subjects treated with at least 1 cycle of AMG 212 in the subcutaneous (SC) arm. These ADAs were neutralizing and resulted in profound exposure loss that was associated with contemporaneous reversal of initial Prostate Surface Antigen (PSA) responses, curtailing durability of PSA response in patients. Pivoting from SC to a continuous intravenous (CIV) administration route remarkably yielded no subjects developing ADA to AMG 212. Through a series of stepwise functional assays, our investigation revealed that alongside a more historically immunogenic route of administration, non-tolerant T cell epitopes within the AMG 212 amino acid sequence were likely driving the high-titer, sustained ADA response observed in the SC arm. DiscussionThese mechanistic insights into the AMG 212 ADA response underscore the importance of performing preclinical immunogenicity risk evaluation as well as advocate for continuous iteration to better our biologics.
Published: 2023
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41. Analyser la connectivité de la trame turquoise : définition, caractérisation et enjeux opérationnels

Author: Céline CLAUZEL, Christophe EGGERT, Simon TARABON, Lili PASQUET, Gilles VUIDEL, Marion BAILLEUL, Claude MIAUD, and Claire GODET
Subjects: connectivité, trame verte et bleue, modélisation, amphibien, réseau écologique, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350
Abstract: Revue Sciences Eaux & Territoires - Vient de paraître en ligneLa fragmentation du paysage se matérialise par une rupture de connexion au sein des réseaux écologiques. Le concept de trame verte et bleue est apparu comme un outil de protection et de restauration des continuités écologiques dans les territoires. De nouvelles trames écologiques ont récemment été proposées pour identifier d’autres discontinuités écologiques effectives. C’est notamment le cas de la trame turquoise associant la trame bleue et la partie de la trame verte en interaction fonctionnelle. La trame turquoise regroupe ainsi différents types d’habitats aquatiques et terrestres dont dépendent de nombreuses espèces d’amphibiens, d’odonates et autres invertébrés ou encore de chiroptères. Cette nouvelle trame bénéficie d’une attention croissante dans le monde opérationnel, alors même que sa définition et les méthodes de caractérisation ne sont pas encore stabilisées. Cet article propose de contribuer à une meilleure définition et compréhension de la trame turquoise. S’appuyant sur la méthode des graphes paysagers, aujourd’hui largement utilisée pour modéliser les réseaux écologiques et mesurer leur connectivité, le projet INTERFACE a permis le développement d’un protocole innovant de réseau multi-habitats pour tenir compte de l’hétérogénéité des habitats dans l’évaluation de la connectivité de la trame turquoise. Il permet ainsi d’aller au-delà de la délimitation d’une zone tampon autour des cours d’eau et d'identifier les zones fonctionnelles à préserver, les zones vulnérables et les points de conflits où il serait intéressant de restaurer des habitats aquatiques et/ou terrestres pour améliorer les connectivités.
Published: 2023
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42. Mutational topography reflects clinical neuroblastoma heterogeneity

Author: Elias Rodriguez-Fos, Mercè Planas-Fèlix, Martin Burkert, Montserrat Puiggròs, Joern Toedling, Nina Thiessen, Eric Blanc, Annabell Szymansky, Falk Hertwig, Naveed Ishaque, Dieter Beule, David Torrents, Angelika Eggert, Richard P. Koche, Roland F. Schwarz, Kerstin Haase, Johannes H. Schulte, and Anton G. Henssen
Subjects: neuroblastoma, mutational signatures, cancer genomics, tumor evolution, ecDNA, complex rearrangements, Genetics, QH426-470, Internal medicine, RC31-1245
Abstract: Summary: Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity. Although clinical risk-defining genomic alterations exist in neuroblastomas, the mutational processes involved in their generation remain largely unclear. By examining the topography and mutational signatures derived from all variant classes, we identified co-occurring mutational footprints, which we termed mutational scenarios. We demonstrate that clinical neuroblastoma heterogeneity is associated with differences in the mutational processes driving these scenarios, linking risk-defining pathognomonic variants to distinct molecular processes. Whereas high-risk MYCN-amplified neuroblastomas were characterized by signs of replication slippage and stress, homologous recombination-associated signatures defined high-risk non-MYCN-amplified patients. Non-high-risk neuroblastomas were marked by footprints of chromosome mis-segregation and TOP1 mutational activity. Furthermore, analysis of subclonal mutations uncovered differential activity of these processes through neuroblastoma evolution. Thus, clinical heterogeneity of neuroblastoma patients can be linked to differences in the mutational processes that are active in their tumors.
Published: 2023
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43. Severity of Local Skin Reactions with 4% 5-Fluorouracil Plus Emollient versus 4% 5-Fluorouracil Alone in Patients with Actinic Keratosis: A Single-Blind Randomised Trial

Author: Eggert Stockfleth, Thomas Jouary, Francesca Farnetani, Antonio Macaya Pascual, Cecilia De Almeida Agudo, Jean-Jacques Voisard, Nathalie Bégeault, and Alain Delarue
Subjects: Actinic keratosis, Emollient, Local skin reactions, Topical 5-fluorouracil, Dermatology, RL1-803
Abstract: Abstract Introduction Topical 5-fluorouracil (5-FU)-containing treatments are effective for actinic keratosis (AK); however, they frequently lead to transient local skin reactions (LSRs), which often result in treatment non-adherence. Methods The aim of this international, phase IV clinical trial was to investigate whether addition of an emollient to topical 4% 5-FU would reduce the frequency and severity of LSRs over 4 weeks of treatment (intervention group) compared with 4% 5-FU alone (control group) in patients with AK. The primary objective was to assess the severity of LSRs (i.e. erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation and erosion/ulceration) at week 4 of treatment (or before, in case of a major local reaction). Key secondary objectives were LSR total scores at weeks 2 and 8, the scores of individual LSR items at each visit, and the proportions of patients with 100% and ≥ 75% AK lesion clearance at week 8. Results In total, 141 patients were included in the efficacy analysis (71 in the intervention group and 70 in the control group). There were no statistically or clinically significant differences between the treatment groups in terms of LSR total score at week 4 (overall and by subgroups defined by the number of lesions and patient age at baseline), scores of individual LSR items at any time point, and AK lesion clearance rates at week 8. LSR scores with topical 4% 5-FU alone were lower than expected. Skin reactions were the most common treatment-emergent adverse events in both groups, leading to treatment discontinuation in nine patients (12.3%) in the intervention group and seven (9.9%) in the control group. No new safety signals were observed with the addition of an emollient to 4% 5-FU. Conclusions Daily emollient applications during the 4-week treatment course did not impact the safety and efficacy profile of 4% 5-FU.
Published: 2023
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44. Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows

Author: Jessica Schwerdtfeger, Annika Krause, Claudia Kalbe, Gemma Mazzuoli-Weber, Anja Eggert, Birger Puppe, Björn Kuhla, and Volker Röttgen
Subjects: Medicine, Science
Abstract: Abstract The aim of the study was to investigate the influence of intraperitoneal N-arachidonoylethanolamide (AEA) on taste preference for feed and water, tongue taste receptor signalling (TAS1R2, GNAT3), and endocannabinoid (CNR1, CNR2, GPR55) and opioid (OPRD1, OPRK1, OPRM1, OPRL1) receptors in the amygdala and nucleus accumbens in periparturient cows. We conducted taste preference tests using unaltered, umami-tasting, and sweet-tasting water and feed, before and after calving. After calving, eight cows received AEA injections (3 µg/(kg bodyweight × day), 25 days), whereas eight control (CON) cows received saline injections. Tissue was sampled 30 days after calving. Before calving, both cow groups preferred sweet-tasting feed and umami-tasting water. After calving, only the AEA-treated group preferred sweet-tasting feed, whereas the CON group showed no clear taste preference. In the amygdala, the mRNA expression of CNR1, OPRD1 (left hemisphere) and OPRK1 (right hemisphere) was lower in AEA animals than in CON animals, whereas no differences were found in the nucleus accumbens and tongue taste receptor expression. In conclusion, AEA administration enhanced existing taste preferences and reduced the expression of specific endocannabinoid and opioid receptors in the amygdala. The results support endocannabinoid-opioid interactions in the control of taste-dependent feed preference in early lactating cows.
Published: 2023
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45. An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results

Author: Milan Barras, Lutz Schmitz, Chris Braumann, Waldemar Uhl, Marina Skrygan, Marie Buchholz, Thomas Meyer, Eggert Stockfleth, Thomas Müller, Jürgen C. Becker, and Thilo Gambichler
Subjects: squamous cell carcinomas, cutaneous squamous cell carcinoma (cSCC), non-melanoma skin cancer (NMSC), cancer, substance GP-2250, chemotherapy, Dermatology, RL1-803
Abstract: Advanced cutaneous squamous cell carcinoma (cSCC) can be a life-threatening disease for which effective and safe treatment in advanced stages is very limited. GP-2250 has been recently proven to have—in vitro and in vivo—antineoplastic effects on cancer cells. This study aims to investigate the potential anti-neoplastic effects of GP-2250 on the cSCC cell lines SCC13 and A431 through dose finding assessments, MTT cytotoxicity assays, cell migration assays, BrdU proliferation assays and FCM analysis. Our preliminary results have shown for the first time evidence for anti-neoplastic effects of GP-2250 on cSCC cells, enhancing cytotoxicity, attenuating cancer cell proliferation, inducing apoptosis and reducing tumour cell migration. Further investigations evaluating the modes of action of GP-2250 on cSCC cell lines are warranted in order to justify the use in vivo studies.
Published: 2023
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46. Peripheral artery disease in patients with schizophrenia as compared to controls

Author: Linea Rosenberg Jørgensen, Cathrine Linnea Hegtmann, Sune P. V. Straszek, Christian Høyer, Christoffer Polcwiartek, Lars J. Petersen, Martin Kamp Dalgaard, Svend Eggert Jensen, and René Ernst Nielsen
Subjects: Atherosclerosis, Toe–brachial index, Cardiovascular disease, Schizophrenia, Peripheral artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background Patients with schizophrenia have an increased prevalence of risk factors for peripheral artery disease (PAD) and is expected to have an increased prevalence of PAD. PAD can be detected utilizing toe–brachial index (TBI) which screens for vascular pathology proximal to the toes. Methods Using a cross-sectional design, we defined the subpopulations: (1) Patients diagnosed with schizophrenia less than 2 years before inclusion (SCZ
Published: 2023
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47. ‘Copper and Bronze in Art’ and the Search for Rare Corrosion Products

Author: Gerhard Eggert
Subjects: basic copper(II) formate, ‘Black Spots’, chalconatronite, copper(II) hydroxide, copper sulfide, curly malachite, Archaeology, CC1-960
Abstract: The information taken from David A. Scott’s book “Copper and Bronze in Art” was crucial for this research on copper corrosion products in Stuttgart. The examples discussed are: (1) the nature and variability of ‘Black Spots’ (or ‘Brown Fuzzies’), mainly copper sulfides, resulting from the action of sulfurous gases on copper containing materials at different relative humidities; (2) cupric hydroxide occurring during maritime corrosion or by cleaning, patination, and pigment synthesis (Bremen blue) when alkaline solutions are used; (3) the wondrous phenomenon of curly malachite, which does not imply any human involvement; (4) chalconatronite formed by the contact of metal to alkaline surface films on soda glass, providing sodium and carbonate ions; (5) the formation of copper formates in contact with glass by the action of electrolytes from the glass hydrolysis and the pollutant formaldehyde reacting to the formate; (6) syntheses and crystal structure determination by powder X-ray diffraction (no single crystals needed) of various basic copper acetates (‘verdigris’) with the aim to better differentiate between historic production methods.
Published: 2023
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48. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author: The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. 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Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. 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Nicolas Kaufman, J. R. Patterson, A. Ryd, E. Salvati, W. Sun, W. D. Teo, J. Thom, J. Thompson, J. Tucker, Y. Weng, L. Winstrom, P. Wittich, D. Winn, S. Abdullin, M. Albrow, J. Anderson, G. Apollinari, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, V. Chetluru, H. W. K. Cheung, F. Chlebana, S. Cihangir, V. D. Elvira, I. Fisk, J. Freeman, Y. Gao, E. Gottschalk, L. Gray, D. Green, O. Gutsche, D. Hare, R. M. Harris, J. Hirschauer, B. Hooberman, S. Jindariani, M. Johnson, U. Joshi, B. Klima, S. Kunori, S. Kwan, C. Leonidopoulos, J. Linacre, D. Lincoln, R. Lipton, J. Lykken, K. Maeshima, J. M. Marraffino, V. I. Martinez Outschoorn, S. Maruyama, D. Mason, P. McBride, K. Mishra, S. Mrenna, Y. Musienko, C. Newman-Holmes, V. O’Dell, O. Prokofyev, N. Ratnikova, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, T. Cheng, S. Das, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreos, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, R. Remington, A. Rinkevicius, N. Skhirtladze, M. Snowball, J. Yelton, M. Zakaria, V. Gaultney, S. Hewamanage, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adams, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haas, S. Hagopian, V. Hagopian, K. F. Johnson, H. Prosper, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, F. Yumiceva, M. R. Adams, L. Apanasevich, V. E. Bazterra, R. R. Betts, I. Bucinskaite, J. Callner, R. Cavanaugh, O. Evdokimov, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, P. Kurt, F. Lacroix, D. H. Moon, C. O’Brien, C. Silkworth, D. Strom, P. Turner, N. Varelas, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, K. Dilsiz, F. Duru, S. Griffiths, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, H. Ogul, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny, M. Murray, D. Noonan, S. Sanders, R. Stringer, J. S. Wood, A. F. Barfuss, I. Chakaberia, A. Ivanov, S. Khalil, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, F. Rebassoo, D. Wright, A. Baden, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, A. Apyan, G. Bauer, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, Y. Kim, M. Klute, Y. S. Lai, A. Levin, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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49. Efficacy and Feasibility of Proton Beam Therapy in Relapsed High-Risk Neuroblastoma-Experiences from the Prospective KiProReg Registry

Author: Danny Jazmati, Barbara Hero, Theresa M. Thole.-Kliesch, Julien Merta, Hedwig E. Deubzer, Christian Bäumer, Feline Heinzelmann, Stefanie Schulze Schleithoff, Friederike Koerber, Angelika Eggert, Rudolf Schwarz, Thorsten Simon, and Beate Timmermann
Subjects: Neuroblastoma, childhood cancer, proton beam therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Despite an intensive multimodal treatment approach, approximately 50% of high-risk (HR) neuroblastoma (NB) patients experience progression. Despite the advances in targeted therapy, high-dose chemotherapy, and other systemic treatment options, radiation therapy (RT) to sites of relapsed disease can be an option to reduce tumor burden and improve chance for disease control. Methods: Patients who received salvage irradiation with proton beam therapy (PBT) for local or metastatic relapse of HR NB within the prospective registry trials KiProReg and ProReg were eligible for this retrospective analysis. Data on patient characteristics, multimodality therapy, adverse events, and oncologic endpoints were evaluated. Adverse events were assessed before, during, and after PBT according to common terminology criteria for adverse events (CTCAE) V4.0. Results: Between September 2013 and September 2020, twenty (11 male; 9 female) consecutive patients experiencing local (N = 9) or distant recurrence (N = 25) were identified for this analysis. Distant recurrences included osteomedullary (N = 11) or CNS lesions (N = 14). Salvage therapy consisted of re-induction chemo- or chemo-immuno-therapy (N = 19), surgery (N = 6), high-dose chemotherapy and stem cell transplantation (N = 13), radiation (N = 20), and concurrent systemic therapy. Systemic therapy concurrent to RT was given to six patients and included temozolomide (N = 4), carboplatine (N = 1), or anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKI) (N = 1). A median dose of 36 Gy was applied to the 34 recurrent sites. Local RT was applied to 15 patients, while five patients, received craniospinal irradiation for CNS relapse. After a median follow-up (FU) of 20 months (4–66), the estimated rate for local control, distant metastatic free survival, and overall survival at 3 years was 68.0%, 37.9%, and 61.6%, respectively. During RT, ten patients (50%) presented with a higher-grade acute hematologic adverse event. Late higher-grade sequelae included transient myelitis with transverse section (N = 2) and secondary malignancy outside of the RT field (N = 1). Conclusion: Our study demonstrates the efficacy and safety of RT/PBT for recurrent HR NB in a multimodality second-line approach. To better define the role of RT for these patients, prospective studies would be desirable.
Published: 2022
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50. Inklusive Medienbildung mit digitalen Spielen

Author: Angela Tillmann, Bastian Krupp, Susanne Eggert, Michael Gurt, Nils Astrath, Johanna Maria Fink, and Franziska Schäfer
Subjects: Inklusion, Partizipation, Medienbildung, junge Menschen mit Beeinträchtigung, digitale Spiele, Gaming, Special aspects of education, LC8-6691
Abstract: Davon ausgehend, dass auf der einen Seite digitales Spiel und digitale Spielkultur hochbedeutsam für Teilhabe- und Partizipationsprozesse junger Menschen sind, auf der anderen Seite insbesondere junge Menschen mit Behinderung nicht in dem Mass daran teilhaben (können) wie Gleichaltrige ohne Beeinträchtigung, setzt sich das Projekt InGame im Rahmen einer qualitativen Studie mit entsprechenden Potenzialen und Hürden des digitalen Spiels auseinander. Ziel des Projekts ist die Entwicklung von pädagogisch-praktischen Spielsettings sowie eines Leitfadens für den pädagogischen Einsatz des digitalen Spiels in der Kinder- und Jugendhilfe. Im Beitrag werden zunächst die dem Projekt zugrunde liegenden Verständnisse von Inklusion sowie von Behinderung dargelegt. Darauf aufbauend werden mit einem Rückbezug auf die Spiele- und Jugendmedienforschung die sozial-integrativen sowie die peer- und jugendkulturell relevanten Potenziale des digitalen Spiel(en)s herausgearbeitet und erläutert. Diese bieten den Hintergrund für die Entwicklung der theoretisch-konzeptionellen Überlegungen des Projekts zur Erforschung der Potenziale einer handlungsorientierten Medienbildung im Feld des digitalen Spiels. Den Abschluss des Beitrags bildet eine skizzenhafte Beschreibung der Limitationen des Projekts.
Published: 2023
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