1. Enteric alpha defensins in norm and pathology
- Author
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Lisitsyn Nikolai A, Bukurova Yulia A, Nikitina Inna G, Krasnov George S, Sykulev Yuri, and Beresten Sergey F
- Subjects
Enteric alpha defensins ,Paneth cells ,innate immunity ,IBD ,colon cancer ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.
- Published
- 2012
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