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Abstract Positioning the positive pressure ventilator in front of the door opening affects the effectiveness of the rescue operation carried out during a fire. An important factor determining the effectiveness of the positive pressure ventilator is also the layout of the rooms within the gas exchange path and the obstacles present there. The purpose of this article is to assess the feasibility of using analyses such as large eddy simulation (LES) to verify the efficiency of mobile fans under simulation conditions, without the need for time-consuming experimentation (also for complex room volumes of buildings). The article presents a comparative analysis to assess the degree of convergence of flow parameters obtained during an experiment (in a multi-story building) and computational fluid dynamics (CFD) simulations. For volumetric flow rate, convergence was achieved at levels ranging from 0.4% (for 5 m) to 11.5% (1 m), and for pressure values, the differences achieved ranged from 0.6% (5 m) to 30.1% (4 m). This paper demonstrates that the LES model can be used to perform CFD simulations in the area of assessing the performance of a positive pressure ventilator. The article also describes a test methodology for determining the flow parameters of an air stream, which can be used to perform numerical simulations.