1. Are comorbidities of patients with adrenal incidentaloma tied to sex?
- Author
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Soraya Puglisi, Anja Barač Nekić, Valentina Morelli, Ylenia Alessi, Michele Fosci, Angelo Pani, Karin Zibar Tomsic, Serena Palmieri, Francesco Ferraù, Anna Pia, Iacopo Chiodini, Darko Kastelan, Giuseppe Reimondo, and Massimo Terzolo
- Subjects
gender ,sexual dimorphism ,adrenal tumors ,cortisol ,MACS ,subclinical Cushing ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundA recent cross-sectional study showed that both comorbidities and mortality in patients with adrenal incidentaloma (AI) are tied to sex. However, few longitudinal studies evaluated the development of arterial hypertension, hyperglycemia, dyslipidemia and bone impairment in patients with AI. The aim of this study is to analyze the impact of sex in the development of these comorbidities during long-term follow-up.MethodsWe retrospectively evaluated 189 patients (120 females, 69 males) with AI, from four referral centers in Italy and Croatia. Clinical characteristics, comorbidities and cortisol after 1-mg dexamethasone suppression test (1-mg DST) were assessed at baseline and at last follow-up visit (LFUV). Median follow-up was 52 (Interquartile Range 25-86) months.ResultsThe rates of arterial hypertension and hyperglycemia increased over time both in females (65.8% at baseline versus 77.8% at LFUV, p=0.002; 23.7% at baseline versus 39.6% at LFUV, p
- Published
- 2024
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