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1. Sex‐related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity

Author

Mark A. Espeland, Hussein Yassine, Kathleen D. Hayden, Christina Hugenschmidt, Wendy L. Bennett, Ariana Chao, Rebecca Neiberg, Steven E. Kahn, José A. Luchsinger, and for the Action for Health in Diabetes (Look AHEAD) Research Group

Subjects
apoliprotein E ε4, cognitive decline, obesity, sex, type 2 diabetes mellitus, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Abstract

Abstract Introduction It is unknown whether rates of cognitive decline differ between older women and men with type 2 diabetes (T2D) and overweight or obesity. Methods Two to four cognitive assessments were obtained across up to 10 years from 2799 adults (mean age 68 years; 62% women) with T2D who had been enrolled in a clinical trial of weight loss intervention. Sex‐related differences in means and rates of decline of cognitive scores were assessed. Results Women outperformed men in verbal learning and processing speed (P

Published
2021
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