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The excessive content of heavy metals and the deficiency of beneficial trace elements in cereals have threatened global food security and human health. As important metal transporters, Natural resistance-associated macrophage proteins (Nramps) are involved in the absorption and transport of various metal ions in plants, including beneficial elements and hazardous heavy metals, yet little is known about their roles in foxtail millet. In this study, 12 Nramps were identified in foxtail millet genome and divided into three clades. Expansion and functional differentiation of SiNramp gene family is evident in the high proportion of gene duplication as well as the diversity in protein structure and expression characteristics. The SiNramp genes exhibited different response patterns to Cd stress in different tissues. Based on the integration of ionome, RNA-seq and orthologous analysis, the association of SiNramp genes with the accumulation of different metal ions was investigated, and the possible functions of several SiNramp genes were predicted, such as SiNramp6 and SiNramp12. In general, this study provides a comprehensive theoretical framework for the study of Nramp genes in foxtail millet and other minor gramineous crops, which will lay a foundation for further research on the mechanism of metal transport and accumulation.

Gain-dissipative systems of various physical origin have recently shown the ability to act as analogue minimisers of hard combinatorial optimisation problems. Whether or not these proposals will lead to any advantage in performance over the classical computations depends on the ability to establish controllable couplings for sufficiently dense short- and long-range interactions between the spins. Here, we propose a polaritonic XY-Ising machine based on a network of geometrically isolated polariton condensates capable of minimising discrete and continuous spin Hamiltonians. We elucidate the performance of the proposed computing platform for two types of couplings: relative and absolute. The interactions between the network nodes might be controlled by redirecting the emission between the condensates or by sending the phase information between nodes using resonant excitation. We discuss the conditions under which the proposed machine leads to a pure polariton simulator with pre-programmed couplings or results in a hybrid classical polariton simulator. We argue that the proposed architecture for the remote coupling control offers an improvement over geometrically coupled condensates in both accuracy and stability as well as increases versatility, range, and connectivity of spin Hamiltonians that can be simulated with polariton networks.

Topological photonics emerged as a novel route to engineer the flow of light. Topologically protected photonic edge modes, which are supported at the perimeters of topologically nontrivial insulating bulk structures, are of particular interest as they may enable low-loss optical waveguides immune to structural disorder. Very recently, there has been a sharp rise of interest in introducing gain materials into such topological photonic structures, primarily aiming at revolutionizing semiconductor lasers with the aid of physical mechanisms existing in topological physics. Examples of remarkable realizations are topological lasers with unidirectional light output under time-reversal symmetry breaking and topologically protected polariton and micro/nanocavity lasers. Moreover, the introduction of gain and loss provides a fascinating playground to explore novel topological phases, which are in close relevance to non-Hermitian and parity-time symmetric quantum physics and are, in general, difficult to access using fermionic condensed matter systems. Here, we review the cutting-edge research on active topological photonics, in which optical gain plays a pivotal role. We discuss recent realizations of topological lasers of various kinds, together with the underlying physics explaining the emergence of topological edge modes. In such demonstrations, the optical modes of the topological lasers are determined by the dielectric structures and support lasing oscillation with the help of optical gain. We also address recent research on topological photonic systems in which gain and loss, themselves, essentially influence topological properties of the bulk systems. We believe that active topological photonics provides powerful means to advance micro/nanophotonics systems for diverse applications and topological physics, itself, as well.

Dopamine neurons have long been thought to facilitate learning by broadcasting reward prediction error (RPE), a teaching signal used in machine learning, but more recent work has advanced alternative models of dopamine’s computational role. Here, I revisit this critical issue and review new experimental evidences that tighten the link between dopamine activity and RPE. First, I introduce the recent observation of a gradual backward shift of dopamine activity that had eluded researchers for over a decade. I also discuss several other findings, such as dopamine ramping, that were initially interpreted to conflict but later found to be consistent with RPE. These findings improve our understanding of neural computation in dopamine neurons.

Abstract The rising rate of single-mother families has gained scholarly and policy attention. Understanding the dynamics in the socio-economic and demographic transformations that have led to the relatively high single-mother families in Ghana is important to advance policy and intervention to mitigate adverse effects of single motherhood. The study sought to examine the trends and predictors of single motherhood in Ghana from 1993 to 2014. This paper was based on data from the last five waves of the Ghana Demographic and Health Survey. Descriptive statistics of proportions with Chi-square test and binary logistic regression were used to assess individual and contextual factors associated with single motherhood in Ghana. The proportion of single motherhood increased significantly over the period from 14.1% in 1993 to 19.5% in 2014. Premarital birth emerged as the major pathway to single motherhood. Among individual factors, the likelihood of single motherhood declines as age at first sex [OR = 0.58; 95% CI = 0.48,0.70] and first birth [OR = 0.43; CI = 0.32,0.59] were 25 years and above. Also, Contraceptive users were less likely to be single mothers than non-users. Contextually, women who profess Islam [OR = 0.58; 95% CI = 0.46, 0.74] were less likely to be single mothers than women who had no religious affiliation. We observed that, after accounting some important factors, women with higher economic status—richer [OR = 0.76; 95% CI = 0.59,0.96] and richest [OR = 0.57; 95% CI = 0.31,0.56] were less likely to be single mothers than poorest women. The findings give an impression of single mothers being over-represented among economically poor women. Policies and programmes meant to mitigate adverse effects of single motherhood should also focus on empowering single mothers and their children as a way of alleviating poverty and improve the well-being of children in this family type, as well as enhance Ghana’s capacity to attain the Sustainable Development Goal 1, particularly target 1.2.

Rooftop detection has numerous applications such as change detection in human settlements, land encroachments, planning routes to rural areas and estimation of solar generation potential of cities. Detecting the number, type and shape of building roofs form part of preliminary procedures to perform a variety of tasks for making decisions. Assessment of rooftops in rural areas is an important task in the estimation of potential solar generation and sizing of solar PV systems which has proven to be very challenging due to the different quality, lighting conditions and resolution of aerial and satellite images. In this research, we implement a mask RCNN algorithm using TensorFlow Object Detection API to detect the rooftop of buildings in a typical rural settlement. The average precision and recall values (@ IoU = 0.5:0.05:0.95) of the trained model were 85% and 88.2% respectively. The results of the experiment show that the approach can effectively and accurately detect and segment rural rooftops from high-resolution aerial images.

Abstract Background The COVID-19 pandemic left countries to rapidly implement diverse and stringent public health measures without recourse to mitigate its effect on the sustenance of routine healthcare services. This study described routine health service disruption and restoration strategies at 6 months into the epidemic in Liberia. Methods Liberia, with 15 counties, has 839 health facilities, with one-third in Montserrado County. A cross-sectional study using a mixed approach - quantitative and qualitative research with concurrent triangulation was conducted using a structured guide for group discussions among key health workers at 42 secondary and most patronized health facilities in 14 counties and 7 Montserrado districts. Additionally, routine health data between January and June 2019 and 2020 were extracted from the source documents to the electronic checklist. We performed a descriptive analysis of quantitative data and plotted the line graph of the relative percentage change. Transcribed audio recording notes were synthesized using ATLAS ti for content analysis to identify the themes and subthemes in line with the study objectives and excerpts presented in the results. Results Liberia declared COVID-19 outbreak on March 16, 2020. From conducted interviews at 41 health facilities, 80% reported disruption in routine health services. From January to June 2020, scheduled routine immunization outreaches conducted decreased by 47%. Using a relative percentage change, outpatient attendance decreased by 32% in May, inpatient admission by 30% in April, malaria diagnosis and treatment by 40% in April, and routine antenatal obstetric care by 28% in April. The fear of contacting COVID-19 infection, redeployment of healthcare workers to COVID-19 response, restriction of movement due to lockdown, inadequate or lack of PPE for healthcare workers, lack of drugs and vaccine supplies for clients, and partial closure of routine healthcare services were common perceived reasons for disruptions. Massive community health education and strict compliance with COVID-19 nonpharmacological measures were some of the health facility recovery strategies. Conclusions The COVID-19 outbreak in Liberia caused a disruption in routine healthcare services, and strategies to redirect the restoration of routine healthcare services were implemented. During epidemics or global health emergencies, countries should sustain routine health services and plan for them.

The Covid-19 pandemic has harmed the sustainability of economic activities in Indonesia. Central Bangka Regency, the Covid-19 pandemic, has also harmed business actors. The purpose of this study was to analyze the mapping of the creative economy sub-sector in Central Bangka Regency and its survival during the Covid-19 pandemic. This study uses a mixed-method analysis approach. Quantitatively, this analysis uses linear regression analysis to identify the influence of government policies on the survival of creative economy businesses during the pandemic. Qualitative analysis is carried out by identifying data on the distribution of the creative economy that still persists during the pandemic and the factors that influence it both internally and externally using the Quantitative Strategic Planning Matrix (QSPM). The results of the analysis obtained are the weighted IFE value of 2.350 and the weighted EFE value of 2.756 which can be plotted in the Internal-External matrix. This shows that the creative economy business in Central Bangka Regency is currently in a period of growth because it previously experienced a reduction in production and distribution during the Covid-19 Pandemic. Meanwhile, based on the results of the QSPM analysis, the main strategy that must be carried out during this pandemic is to strengthen promotions using the digital marketing concept. Meanwhile, based on the results of linear regression analysis, it was found that there was a positive relationship between the survival of the creative economy business during the pandemic and the creative economy management program in the Central Bangka Regency.

Este artículo tiene como objetivo analizar el carácter fragmentario del discurso que puede encontrarse en ciertos diarios personales del contexto español de la democracia. En estos diarios el fragmento condiciona la construcción de un relato literario y, al mismo tiempo, se vincula con la introducción de determinados formatos genéricos relacionados con la literatura ensayística. Este diálogo entre fragmento y relato hacen del diario literario uno de los textos más innovadores de la literatura española reciente, lo que se desarrollará en este trabajo a partir del análisis de los diarios de Trapiello, Jiménez Lozano, Freixas o Uriarte, entre otros.

IL-38 is a recently discovered cytokine and member of the IL-1 Family. In the IL-1 Family, IL-38 is unique because the cytokine is primarily a B lymphocyte product and functions to suppress inflammation. Studies in humans with inflammatory bowel disease (IBD) suggest that IL-38 may be protective for ulcerative colitis or Crohn’s disease, and that IL-38 acts to maintain homeostasis in the intestinal tract. Here we investigated the role of endogenous IL-38 in experimental colitis in mice deficient in IL-38 by deletion of exons 1-4 in C57 BL/6 mice. Compared to WT mice, IL-38 deficient mice subjected to dextran sulfate sodium (DSS) showed greater severity of disease, more weight loss, increased intestinal permeability, and a worse histological phenotype including increased neutrophil influx in the colon. Mice lacking IL-38 exhibited elevated colonic Nlrp3 mRNA and protein levels, increased caspase-1 activation, and the concomitant increased processing of IL-1β precursor into active IL-1β. Expression of IL-1α, an exacerbator of IBD, was also upregulated. Colonic myleloperoxidase protein and Il17a, and Il17f mRNA levels were higher in the IL-38 deficient mice. Daily treatment of IL-38 deficient mice with an NLRP3 inhibitor attenuated diarrhea and weight loss during the recovery phase. These data implicate endogenous IL-38 as an anti-inflammatory cytokine that reduces DSS colitis severity. We propose that a relative deficiency of IL-38 contributes to IBD by disinhibition of the NLRP3 inflammasome.

Abstract Background Immediate implants are frequently employed in the anterior maxillary area. However, the installation of dental implants simultaneously with tooth extraction can also provide with benefits in the posterior areas with a reduction in time prior the recovery of the masticatory function. Results previously reported in the literature show high-survival and success rates for implants placed in extraction sockets in molar areas; however, this topic has received limited systematic analysis. Material and methods Electronic and manual literature searches were performed by two independent reviewers in several data-bases, including MEDLINE, EMBASE, and Cochrane Oral Health Group Trials Register, for articles up to January 2019 reporting outcomes of immediate implants placed in molar areas. Primary outcomes included survival and success rates, as well as marginal bone loss. Secondary outcomes included the influence of implant position, type of implant connection, grafting protocol, flap or flapless approach, implant diameter, surgical phase, presence of buccal plate, and loading protocol. Results Twenty studies provided information on the survival rate, with a total sample of 1.106 implants. The weighted mean survival rate of immediate implants after 1 year of follow-up was 96.6%, and the success rate was 93.3%. On the other hand, marginal bone loss was 1.29 ± 0.24 mm. Secondary outcomes demonstrated that grafting the gap and the loading protocol have an effect on survival and success rates. Similarly, the presence or absence of the buccal bone affect crestal bone levels. Meta-analysis of 4 investigations showed a weighted mean difference of 0.31 mm ± 0.8 IC 95% (0.15–0.46) more marginal bone loss at immediate implant placement versus implants in healed sites (p < 0.001) I 2 = 15.2%. Conclusion In selected scenarios, immediate implant placement in molar extraction socket might be considered a predictable technique as demonstrated by a high survival and success rates, with minimal marginal bone loss.

Introduction Cervical cancer is the second most common female cancer in Ghana. The disease and its treatment significantly affect survivors’ health-related quality of life (HRQoL). We determined the overall quality of life (QoL) and identified its predictors among cervical cancer survivors after treatment. Materials and methods A hospital-based cross-sectional analytical study was conducted on 153 disease-free cervical cancer survivors who completed curative treatment between January 2004 and December 2018 at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana. We used the European Organization for Research and Treatment of Cancer core-30 item (EORTC QLQ-C30) and cervical cancer module (EORTC QLQ-CX24) to assess the survivors’ overall QoL. QoL domain scores were dichotomised as affected or unaffected by disease and its treatment. Significant differences between the affected and unaffected groups within each QoL domain were determined using the student T-test. We used Kruskal-Wallis and Dunn’s tests to examine the difference in QoL domains between treatment types, with significance based on Bonferroni corrections. Multivariable logistic regression was performed to identify predictors of overall QoL. A p-value of less than 0.05 was considered statistically significant. Results One hundred and fifty-three (153) women having a mean age of 58.3 (SD 11.4) years were studied. The overall QoL score was 79.6 (SD 16.0), and 74.5% of survivors reported good QoL score within the median follow up time of 41.8 months (interquartile range [IQR], 25.5–71.1 months) after cervical cancer diagnosis. Although the majority (66.0–84.3%) of the QoL functioning scale were unaffected, about a fifth (22.2%) to a third (34.5%) of the subjects had perceptual impairment in cognitive and role functioning. Financial difficulties, peripheral neuropathy and pain were most common symptoms reported as affected. A third of the survivors were worried that sex would be painful, and 36.6% indicated that their sexual activity as affected. The overall QoL scores for survivors who had surgery, chemoradiation and radiation-alone were 86.1 (SD 9.7), 76.9 (SD 17.7), and 80.7 (SD 14.7), respectively (p = 0.025). The predictors of survivor’s overall QoL were loss of appetite [Adjusted Odd Ratio (AOR) = 9.34, 95% Confidence Interval (CI) = 2.13–35.8, p = 0.001], pain (AOR = 3.53, 95% CI = 1.25–9.31, p = 0.017) and body image (AOR = 5.89, 95% CI = 1.80–19.27, p = 0.003). Conclusion About 75% of the survivors had a good overall quality of life. Primary surgical treatment affords the best prospects for quality of life with the least symptom complaints and financial burden. Loss of appetite, pain or diminution in body image perception predicted the overall quality of life of cervical cancer survivors after treatment.

The fully aquatic African clawed frog, Xenopus laevis, has an unusual and highly adapted nose that allows it to separately sample both airborne and waterborne stimuli. The function of the adult water nose has received little study, despite the fact that it is quite likely to receive information about conspecifics through secretions released into the water and could aid the frog in making decisions about social and reproductive behaviors. To assess the potential for chemical communication in this species, we developed an in situ electroolfactogram preparation and tested the olfactory responses of adult males to cloacal fluids and skin secretions from male and female conspecifics. We found robust olfactory responses to all conspecific stimuli, with greatest sensitivity to female cloacal fluids. These results open the door to further testing to identify compounds within cloacal fluids and skin secretions that are driving these responses and examine behavioral responses to those compounds. Understanding the role of chemical communication in social and reproductive behaviors may add to our rich understanding of vocal communication to create a more complete picture of social behavior in this species.

This study evaluated the integrity of the geosphere of the Accra Plains to host a radioactive waste disposal facility for Ghana’s radioactive waste materials. The study thus assessed the migration of radioactive contaminant from a hypothetical radioactive waste disposal facility through the geosphere to the biosphere in the Accra Plains. The Accra Plains is predominantly underlain by schist rocks, hence the hydrogeologic parameters of schist rock from literature were used as input data. AMBER software was used to develop a model to estimate the peak total annual effective dose from all the radionuclides at various receptor locations. The endpoint of interest was the dose received by a receptor for ingesting water from an abstraction well located at distance; 100 m, 200 m, 500 m, 1 km, 2 km, 3 km, 4 km and 5 km from the hypothetical repository. From the simulation, the annual effective dose values ranged from 2.07E-25 Sv/y to 6.45E-17 Sv/y which are all below the International Commission on Radiological Protection (ICRP) dose constraint of 0.3 mSv/y. The lifetime cancer risk for ingesting water from the abstraction wells were then calculated from the annual effective dose values. The resulting values ranged from 1.06E-24 to 3.30E-16 thus indicating that the potential cancer risk for ingesting water from the abstraction wells located within 100 m to 5 km from the hypothetical disposal facility is negligible. The model results demonstrate that, siting a disposal facility in the study area might not pose any significant risk to the sprawling population and the environment.

Electricity prosumption is gaining ground due to price reduction in solar PV systems. The presence of prosumers on the low voltage grid is said to compromise power quality in the grid. Many researchers have reported over-voltage and high power loss in the prosumer grid. Power utility regulators ensure that operators work within voltage and power loss benchmarks. To meet voltage and power loss benchmarks, operators use tap changers, capacitor banks, and static volt-ampere-reaction (VAr) compensators. Finding the optimal placement of such compensators on the low voltage prosumer grid to minimise voltage deviation and line loss is always a problem. Their allocation is not a trivial task when the objective is to provide a comprehensive benefit to the power system. This paper aims to analyse the suitability of using reactive power support (RPS) and solar photovoltaics to achieve active voltage management, minimise power loss, and reduce transformer capacity in prosumer grids PV using the python optimisation algorithm. The results show that solar photovoltaic injection and reactive power compensation positively and negatively impact the prosumer grid. Operating the grid with PV and RPS injections with specific transformers capacities does not create over-voltage and high-power loss problems. The results obtained from the scenarios show that operating the grid as a consumer grid has high power loss than operating it with PV injection and RPS.

This study evaluated the integrity of the geosphere of the Accra Plains to host a radioactive waste disposal facility for Ghana’s radioactive waste materials. The study thus assessed the migration of radioactive contaminant from a hypothetical radioactive waste disposal facility through the geosphere to the biosphere in the Accra Plains. The Accra Plains is predominantly underlain by schist rocks, hence the hydrogeologic parameters of schist rock from literature were used as input data. AMBER software was used to develop a model to estimate the peak total annual effective dose from all the radionuclides at various receptor locations. The endpoint of interest was the dose received by a receptor for ingesting water from an abstraction well located at distance; 100 m, 200 m, 500 m, 1 km, 2 km, 3 km, 4 km and 5 km from the hypothetical repository. From the simulation, the annual effective dose values ranged from 2.07E-25 Sv/y to 6.45E-17 Sv/y which are all below the International Commission on Radiological Protection (ICRP) dose constraint of 0.3 mSv/y. The lifetime cancer risk for ingesting water from the abstraction wells were then calculated from the annual effective dose values. The resulting values ranged from 1.06E-24 to 3.30E-16 thus indicating that the potential cancer risk for ingesting water from the abstraction wells located within 100 m to 5 km from the hypothetical disposal facility is negligible. The model results demonstrate that, siting a disposal facility in the study area might not pose any significant risk to the sprawling population and the environment.

BackgroundAngiogenic growth mediators (AGMs) and oxidative stress (OS) both play essential roles in normal placental vascular development and as such, placental alterations in these factors contribute to pre-eclampsia (PE). Suboptimal health status (SHS), an intermediate between health and disease, has been associated with imbalanced AGMs and OS biomarkers. Thus, SHS pregnant women may be at increased risk of developing PE and may present abnormal placental alteration and expression of AGMs and OS compared to optimal health status (OHS) pregnant women. We examined the histopathological morphology, immunohistochemical expression of AGMs antibodies and oxidative DNA damage marker in the placentae of SHS and OHS pregnant women who developed early-onset PE (EO-PE) and late-onset (LO-PE) compared to normotensive pregnancy (NTN-P).MethodsThis nested case-control study recruited 593 singleton normotensive pregnant women at baseline (10-20 weeks gestation) from the Ghanaian Suboptimal Health Status Cohort Study (GHOACS) undertaken at the Komfo Anokye Teaching Hospital, Ghana. Socio-demographic, clinical and obstetrics data were collected, and a validated SHS questionnaire-25 (SHSQ-25) was used in classifying participants into SHS (n = 297) and OHS (n = 296). Participants were followed until the time of PE diagnosis and delivery (32-42 weeks gestation). Blood samples were collected at the two-time points and were assayed for AGMs; soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PIGF), vascular endothelial growth factor-A (VEGF-A), and soluble endoglin (sEng), and OS biomarkers; 8-hydroxydeoxyguanosine (8-OHdG), 8-epiprostaglandinF2-alpha (8- epi-PGF2α) and total antioxidant capacity (TAC) using ELISA. Placental samples were collected for histopathological and immunohistochemical analysis.ResultsOf the 593 pregnant women, 498 comprising 248 SHS and 250 OHS women returned for delivery and were included in the final analysis. Of the 248 SHS women, 56, 97 and 95 developed EO-PE, LO-PE and NTN-P, respectively, whereas 14, 30 and 206 of the 250 OHS mothers developed EO-PE, LO-PE and NTN-P, respectively. At baseline, SHS_NTN pregnant women had a significant imbalance in AGMs and OS biomarkers compared to OHS_NTN pregnant women (pLO-PE) more than OHS groups who developed PE (EO-PE>LO-PE) when all were compared to NTN-P (pLO-PE more than OHS- pregnant women who developed EO-PE>LO-PE when all were compared to NTN-P (pConclusionIncreased lesions, oxidative DNA damage, and imbalanced expression between pro-and anti-AGMs are associated more with SHS-embodied PE placentae rather than OHS-embodied PE subtypes, thus potentially allowing differential evaluation of PE.

IntroductionCervical cancer is the second most common female cancer in Ghana. The disease and its treatment significantly affect survivors' health-related quality of life (HRQoL). We determined the overall quality of life (QoL) and identified its predictors among cervical cancer survivors after treatment.Materials and methodsA hospital-based cross-sectional analytical study was conducted on 153 disease-free cervical cancer survivors who completed curative treatment between January 2004 and December 2018 at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana. We used the European Organization for Research and Treatment of Cancer core-30 item (EORTC QLQ-C30) and cervical cancer module (EORTC QLQ-CX24) to assess the survivors' overall QoL. QoL domain scores were dichotomised as affected or unaffected by disease and its treatment. Significant differences between the affected and unaffected groups within each QoL domain were determined using the student T-test. We used Kruskal-Wallis and Dunn's tests to examine the difference in QoL domains between treatment types, with significance based on Bonferroni corrections. Multivariable logistic regression was performed to identify predictors of overall QoL. A p-value of less than 0.05 was considered statistically significant.ResultsOne hundred and fifty-three (153) women having a mean age of 58.3 (SD 11.4) years were studied. The overall QoL score was 79.6 (SD 16.0), and 74.5% of survivors reported good QoL score within the median follow up time of 41.8 months (interquartile range [IQR], 25.5-71.1 months) after cervical cancer diagnosis. Although the majority (66.0-84.3%) of the QoL functioning scale were unaffected, about a fifth (22.2%) to a third (34.5%) of the subjects had perceptual impairment in cognitive and role functioning. Financial difficulties, peripheral neuropathy and pain were most common symptoms reported as affected. A third of the survivors were worried that sex would be painful, and 36.6% indicated that their sexual activity as affected. The overall QoL scores for survivors who had surgery, chemoradiation and radiation-alone were 86.1 (SD 9.7), 76.9 (SD 17.7), and 80.7 (SD 14.7), respectively (p = 0.025). The predictors of survivor's overall QoL were loss of appetite [Adjusted Odd Ratio (AOR) = 9.34, 95% Confidence Interval (CI) = 2.13-35.8, p = 0.001], pain (AOR = 3.53, 95% CI = 1.25-9.31, p = 0.017) and body image (AOR = 5.89, 95% CI = 1.80-19.27, p = 0.003).ConclusionAbout 75% of the survivors had a good overall quality of life. Primary surgical treatment affords the best prospects for quality of life with the least symptom complaints and financial burden. Loss of appetite, pain or diminution in body image perception predicted the overall quality of life of cervical cancer survivors after treatment.

COVID-19 remains a serious disruption to human health, social, and economic existence. Reinfection with the virus intensifies fears and raises more questions among countries, with few documented reports. This study investigated cases of COVID-19 reinfection using patients' laboratory test results between March 2020 and July 2021 in Liberia. Data obtained from Liberia's Ministry of Health COVID-19 surveillance was analyzed in Excel 365 and ArcGIS Pro 2.8.2. Results showed that with a median interval of 200 days (Range: 99-415), 13 out of 5,459 cases were identified and characterized as reinfection in three counties during the country's third wave of the outbreak. Eighty-six percent of the COVID-19 reinfection cases occurred in Montserrado County within high clusters, which accounted for over 80% of the randomly distributed cases in Liberia. More cases of reinfection occurred among international travelers within populations with high community transmissions. This study suggests the need for continued public education and surveillance to encourage longer-term COVID-19 preventive practices even after recovery.

Birds can assess nest predation risk and adjust their parental activity accordingly. Risk taking behavior should be related to investment in reproduction as well as to confidence in parenthood that often differ between sexes. In those cases, sexual differences in risk taking behavior may be expected. For example, in blue tits, females invest more time and energy than males in nest-building, egg laying and incubation. Furthermore, confidence in parenthood is supposed to be higher for females, as extrapair paternity is common in this species. Therefore, the reproductive value of nestlings may be higher for females than for males and the former may assume greater risks to ensure nestling growth and maximize their reproductive success. We examined potential sexual differences in the risk assumed by parents in relation to perceived risk of predation inside the nest cavity, where predation risk perception may be higher. We increased perceived predation risk by adding predator chemical cues inside blue tit (Cyanistes caeruleus) nest-boxes, and we tested whether female and male parents differed in the risk assumed when taking care of nestlings. Females and males did not differ in the risk assumed in response to perceived predation risk. However, females reduced time devoted to nest sanitation activities when predator chemical cues were detected inside the nest-box, likely as an anti-predatory strategy to minimize their own risk of predation. Therefore, these results add to the evidence that birds can detect chemical cues of predators inside the nest cavity and suggest that the behavioral response to an increase in risk of predation perceived through olfactory cues is not sex-dependent in blue tit.

This study presents a biophotocatalytic system as a sustainable technology for the recovery of clean water and renewable energy from wastewater, thereby providing a unique opportunity to drive industrialization and global sustainable development throughputs. Herein, inhouse magnetized photocatalyst (Fe-TiO2) with surface area 62.73 m2/g synthesized via co-precipitation, was hypothesized to hasten an up-flow anaerobic sludge blanket (UASB) reactor for the treatment of local South Africa municipality wastewater with the benefit of high-quality biogas production. A lab scale UASB process with a working volume of 5 L coupled with two UV-lights (T8 blacklight-blue tube, 365 nm, 18 W) was operated batchwise under mesophilic conditions for the period of 30 days with a constant organic load charge of 2.76 kg COD/m3. d. This biophotocatalytic system performance was investigated and compared with and without the Fe-TiO2 charge (2–6 g) with respect to effluent quality, biogas production and CO2 methanation. Using chemical oxygen demand (COD) measured as the degree of degradation of the pollutants, the best efficiency of 93% COD removal was achieved by a 4 g Fe-TiO2 charge at 14 days and pH of 7.13, as compared to zero charge where only 49.6% degradation was achieved. Under the same charge, cumulative biogas and methane content of 1500 mL/g COD.d and 85% were respectively attained as compared with the control with 400 mL/g COD.d and 65% methane content. Also, the energy produced can be used to offset the energy utilized by the UV-light for the wastewater abatement and other limitations of photocatalysis. The BP system was found to be an eco-friendly and cost-effective technology to be explored in water treatment settings.

The water–energy–food (WEF) nexus has become a key concept to promote the cross-sectoral coordination toward sustainable development. In particular, understanding the interdependences of these pillars, as well as addressing a life cycle perspective, is essential when evaluating food production systems. This study explores the environmental impacts and nutritional quality of potato chips, addressing life cycle thinking and a WEF nexus approach. For this purpose, the combined application of life cycle assessment (LCA) and the Nutrient-Rich Food 9.3 (NRF9.3) index was considered to identify the main environmental hotspots and advanced opportunities. The results indicated a major contribution of the cultivation stage on water use, whereas the processing accounted for most of the impacts in energy-related indicators and eutrophication potentials. Improvement opportunities reside in the joint application of drip irrigation, allowing to achieve important water savings, as well as the use of natural gas or pellets instead of diesel, which constitute cleaner energy sources. On the other hand, a poor nutritional density of potato chips became evident from the quantification of the NRF9.3, which can be significantly improved if potatoes undergo a roasted process instead of frying.

The processes governing lymphocyte fate (division, differentiation, and death), are typically assumed to be independent of cell age. This assumption has been challenged by a series of elegant studies which clearly show that, for murine cells in vitro, lymphocyte fate is age-dependent and that younger cells (i.e., cells which have recently divided) are less likely to divide or die. Here we investigate whether the same rules determine human T cell fate in vivo. We combined data from in vivo stable isotope labeling in healthy humans with stochastic, agent-based mathematical modeling. We show firstly that the choice of model paradigm has a large impact on parameter estimates obtained using stable isotope labeling i.e., different models fitted to the same data can yield very different estimates of T cell lifespan. Secondly, we found no evidence in humans in vivo to support the model in which younger T cells are less likely to divide or die. This age-dependent model never provided the best description of isotope labeling; this was true for naïve and memory, CD4+ and CD8+ T cells. Furthermore, this age-dependent model also failed to predict an independent data set in which the link between division and death was explored using Annexin V and deuterated glucose. In contrast, the age-independent model provided the best description of both naïve and memory T cell dynamics and was also able to predict the independent dataset.

Background Approximately one in every five adolescent girls in Kenya has either had a live birth or is pregnant with her first child. There is an urgent need to understand the language and symbols used to represent adolescent pregnancy, if the current trend in adolescent pregnancy is to be reversed. Agreement on the definition of a societal problem is an important precursor to a social issue’s political prioritization and priority setting. Methods We apply the Public Arenas Model to appraise the environments, definitions, competition dynamics, principles of selection and current actors involved in problem-solving and prioritizing adolescent pregnancy as a policy issue. Using a focused ethnographic approach, we undertook semi-structured interviews with 14 members of adolescent sexual reproductive health networks at the national level and conducted thematic analysis of the interviews. Findings We found that existing definitions center around adolescent pregnancy as a “disease” that needs prevention and treatment, socially deviant behaviour that requires individual agency, and a national social concern that drains public resources and therefore needs to be regulated. These competing definitions contribute to the rarity of the topic achieving traction within the political agenda and contribute to conflicting solutions, such as lowering the legal age of consenting to sex, while limiting access to contraceptive information and services to minors. Conclusion This paper provides a timely theoretical approach to draw attention to the different competing definitions and subsequent divergent interpretations of the problem of adolescent pregnancy in Kenya. Adolescent reproductive health stakeholders need to be familiar with the existing definitions and deliberately reframe this important social problem for better political prioritization and resource allocation. We recommend a definition of adolescent pregnancy that cuts across different arenas, and leverages already existing dominant and concurrent social and economic issues that are already on the agenda table.

The road to decarbonization has led to the exploration of sustainable energy sources for domestic and industrial use [...]

Background: Recent data have shown that the human papillomavirus (HPV) vaccine could impact on a decrease in high-grade cervical intraepithelial lesions (HSIL) in women who have undergone surgical treatment. This study aimed to evaluate the efficacy of human papilloma virus (HPV) vaccination against persistent/recurrent disease in patients undergoing conization for high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia-grade 2-3 (HSIL/CIN 2-3). Methods: From January 2009 to March 2019, 563 patients with HSIL/CIN 2-3 underwent conization. The population was divided into two groups according to vaccination status: vaccinated-group (V-Group) and non-vaccinated-group (NV-Group). Bivalent or quadrivalent vaccines were administered indiscriminately. A follow-up was scheduled every 6–12 months according to clinical guidelines. The mean follow-up was 29.6 vs. 36.5 months in the V-group and NV-group, respectively. Results: 277 (49.2%) women were vaccinated, while 286 (50.8%) were not. Overall, persistent/recurrent HSIL/CIN 2-3 was presented by 12/277 (4.3%) women in the V-Group and 28/286 (9.8%) in the NV-Group (HR: 0.43, 95% Confidence interval 0.22–0.84, p = 0.014). Vaccination was associated with a 57% reduction in HSIL persistence/recurrence after treatment. When no disease was present in the first 6-month follow-up visit, persistence/recurrence rates were very low in both groups: 1.1% in the V-Group vs. 1.5% in the NV-Group (p > 0.05). The factor associated with a high-risk of HSIL persistence/recurrence was the presentation of a positive co-test in the first control after treatment (p < 0.001). Conclusions: Our results corroborate the benefit of HPV vaccination in woman treated for HSIL/CIN 2-3, showing a reduction of persistent/recurrent HSIL/CIN 2-3.

Over the past decades, solar energy has gained much attention in Ghana, especially after the 2012–2016 power crisis. The government through Public-Private Partnerships (PPPs) has attempted to increase the shares of solar generation to augment its efforts in reducing the energy deficit of the country, especially in remote and off-grid communities. However, the extent to which PPP has been utilized as a viable tool for solar sector development in Ghana is questionable. This study discusses the current state of PPPs in Ghana’s solar industry and compares how it has been efficiently used as a tool to promote the solar industry in South Africa and Morocco. Fundamental theories such as Altruism, Game, Principal-agent, and Pareto Optimality (PO) were used as analytical tools to examine how PPPs are handled in the selected cases. The study ascertains that the Game and PO are applicable theories that have guided SA and Morocco’s solar infrastructural development. This study discovered that PPP has been efficiently used in SA and Morocco to push its solar industry to be among the best in the world and Ghana can perfectly emulate it. The study further reveals that the Principal-agent analogy and altruistic intent of the Ghanaian government tend to discourage Private sector participation in the solar industry. It further suggests the Pareto Optimality, Game approach, and a win-win transparent attitude towards PPPs. This study recommends a well-developed PPP structure and law for Ghana. It encourages transparency and discourages partisan preferentialism to increase PPPs in Ghana’s solar industry.

Particulate matter with aerodynamic diameters lower than 10 µm, (PM10) aerosol samples were collected during summer 2013 within the framework of the Chemistry and Aerosol Mediterranean Experiment (ChArMEx) at two sites located north (Capo Granitola) and south (Lampedusa Island), respectively, of the main Mediterranean shipping route in the Straight of Sicily. The PM10 samples were collected with 12 h time resolutions at both sites. Selected metals, main anions, cations and elemental and organic carbon were determined. The evolution of soluble V and Ni concentrations (typical markers of heavy fuel oil combustion) was related to meteorology and ship traffic intensity in the Straight of Sicily, using a high-resolution regional model for calculation of back trajectories. Elevated concentration of V and Ni at Capo Granitola and Lampedusa are found to correspond with air masses from the Straight of Sicily and coincidences between trajectories and positions of large ships; the vertical structure of the planetary boundary layer also appears to play a role, with high V values associated with strong inversions and a stable boundary layer. The V concentration was generally lower at Lampedusa than at Capo Granitola V, where it reached a peak value of 40 ng m−3. Concentrations of rare earth elements (REEs), La and Ce in particular, were used to identify possible contributions from refineries, whose emissions are also characterized by elevated V and Ni amounts; refinery emissions are expected to display high La ∕ Ce and La ∕ V ratios due to the use of La in the fluid catalytic converter systems. In general, low La ∕ Ce and La ∕ V ratios were observed in the PM samples. The combination of the analyses based on chemical markers, air mass trajectories and ship routes allows us to unambiguously identify the large role of the ship source in the Straight of Sicily. Based on the sampled aerosols, ratios of the main aerosol species arising from ship emission with respect to V were estimated with the aim of deriving a lower limit for the total ship contribution to PM10. The estimated minimum ship emission contributions to PM10 were 2.0 µg m−3 at Lampedusa and 3.0 µg m−3 at Capo Granitola, corresponding with 11 and 8.6 % of PM10, respectively.

Introduction: The task of Group II was to review and update the existing data concerning extraction socket preservation with or without membranes and soft tissue influence on post-extraction alveolar ridge preservation; extraction socket preservation using different biomaterials as bone grafts, growth factors, and stem cells. Special interest was paid to the dental implant placement outcomes within grafted sockets. Material and Methods: The main areas evaluated by this group were as follows: quantitative and qualitative assessment of the effect of different alveolar preservation techniques performed immediately after tooth extraction, with or without membranes and/or soft tissue grafting, and the use of different bone substitutes, stem cells or growth factors in the postextraction socket. Evaluation of the treatment outcomes of dental implants placed in the grafted sockets in terms of primary and secondary outcomes were assessed. The systematic reviews and/or meta-analyses were registered in PROSPERO, an international prospective register of systematic reviews: http://www.crd.york.ac.uk/PROSPERO/. TThe literature in the corresponding areas of interest was screened and reported following the PRISMA guidelines (Preferred Reporting Item for Systematic Review and Meta-Analysis) Statement: http://www.prisma-statement.org/. Method of preparation of the systematic reviews, based on comprehensive search strategies, was discussed and standardized. The summary of the materials and methods employed by the authors in preparing the systematic reviews and/or meta-analyses is presented in the Preface chapter. Results: The results and conclusions of the review process are presented in the respective papers. Three systematic reviews and one systematic review and meta-analysis were performed. The group's general commentaries, consensus statements, clinical recommendations and implications for research are presented in this article.

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experimental suspensions with two particle sizes and three viscosities, one commercial suspension) in physical and biological tests. The median particle size (d50) categories of the experimental suspensions were 0.37–1.33 and 3.12–3.50 µm and their viscosity levels were 1.3, 7.0, and 15 mPa·s. Smaller particle size facilitated ocular absorption of indomethacin to the aqueous humor of albino rabbits. In aqueous humor the AUC values of indomethacin suspensions with different particle sizes, but equal viscosity, differed over a 1.5 to 2.3-fold range. Higher viscosity increased ocular absorption 3.4–4.3-fold for the suspensions with similar particle sizes. Overall, the bioavailability range for the suspensions was about 8-fold. Instillation of larger particles resulted in higher tear fluid AUC values of total indomethacin (suspended and dissolved) as compared to application of smaller particles. Despite these tear fluid AUC values of total indomethacin, instillation of the larger particles resulted in smaller AUC levels of indomethacin in the aqueous humor. This suggests that the small particles yielded higher concentrations of dissolved indomethacin in the tear fluid, thereby leading to improved ocular bioavailability. This new conclusion was supported by ocular pharmacokinetic modeling. Both particle size and viscosity have a significant impact on drug concentrations in the tear fluid and ocular drug bioavailability from topical suspensions. Viscosity and particle size are the key players in the complex interplay of drug retention and dissolution in the tear fluid, thereby defining ocular drug absorption and bioequivalence of ocular suspensions.

A real case study of an energy system based on a Solar Assisted Heat Pump (SAHP) fed by hybrid photovoltaic-thermal solar panels (PVT) and seasonal storage (SS) is presented in this paper. Exergy and exergy cost analyses are proposed as complementary methods for the assessment and better understanding of the efficiency of this cogeneration solar configuration. The system performance takes advantage of storage heat in summer, when the solar resource is high in Spain, and is then later consumed during the cold winter (heating season). The building is devoted to social housing, and it is currently under construction. The assessment is based on simulations developed using TRNSYS, a dynamic simulation software for energy systems. Results show that the unit exergy cost of the solar field is around 6. The cost of the seasonal storage is higher, about 13, and its formation is affected both by its own irreversibility and by the irreversibility of the PVT solar field. The cost of the heat delivered by the heat pump is around 15, being affected by all the upstream units and even by the grid. Besides, the analysis points out strategies for improving the system efficiency, such as increasing the size of the storage tank or improving the control strategy of the boiler.

Robotics technology has become increasingly common both for businesses and for private citizens. Primary and secondary schools, as a mirror of societal evolution, have increasingly integrated science, technology, engineering and math concepts into their curricula. Our research questions are: “In teaching robotics to primary and secondary school students, which pedagogical-methodological interventions result in better understanding and knowledge in the use of sensors in educational robotics?”, and “In teaching robotics to primary and secondary school students, which analytical methods related to Learning Analytics processes are proposed to analyze and reflect on students’ behavior in their learning of concepts and skills of sensors in educational robotics?”. To answer these questions, we have carried out a systematic review of the literature in the Web of Science and Scopus databases regarding robotics sensors in primary and secondary education, and Learning Analytics processes. We applied PRISMA methodology and reviewed a total of 24 articles. The results show a consensus about the use of the Learning by Doing and Project-Based Learning methodologies, including their different variations, as the most common methodology for achieving optimal engagement, motivation and performance in students’ learning. Finally, future lines of research are identified from this study.

Are we witnessing a decline in the social significance of music? On one hand, technological innovations, especially digitalization, have changed social forms of accessing music, with the increasing importance of individual modes that do not require the face‑to‑face personal networks that had previously enabled social groups to construct their identities around music. On the other hand, the global cultural market logic of pick and mix and use and discard has had an impact on music, making it difficult to provide social meaning and identity. Based on these observations, this article proposes that the ‘decline’ is, in fact, a change in the social meaning of music, from an element involved in the construction of identity to an element of communicative sociality. Its main function today is that of sharing, providing a common language for sociality where neo‑tribes are dissolving.

Background and objectives: The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established. Method: We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally. Results: Vitamin D deficiency (25OHD3

In the present work, the effect of gamma radiation on the performance of different types of erbium-doped fibers (EDFs) when they are used in a fiber ring cavity (FRC) configuration is studied. Several pieces of commercial EDF are gamma-ray irradiated with different doses to evaluate the output power variations over time. The influence of different doses, from 150 Gy to 1000 Gy, over the output power level measurement and their amplified spontaneous emission (ASE) are experimentally evaluated both in the C and L bands. By using an FRC configuration we can detect the presence of gamma radiation. We can also estimate the irradiation doses applied to EDFs by measuring the slope of the short-term emission power.

Pathogens hitting the plant cell wall is the first impetus that triggers the phenylpropanoid pathway for plant defense. The phenylpropanoid pathway bifurcates into the production of an enormous array of compounds based on the few intermediates of the shikimate pathway in response to cell wall breaches by pathogens. The whole metabolomic pathway is a complex network regulated by multiple gene families and it exhibits refined regulatory mechanisms at the transcriptional, post-transcriptional, and post-translational levels. The pathway genes are involved in the production of anti-microbial compounds as well as signaling molecules. The engineering in the metabolic pathway has led to a new plant defense system of which various mechanisms have been proposed including salicylic acid and antimicrobial mediated compounds. In recent years, some key players like phenylalanine ammonia lyases (PALs) from the phenylpropanoid pathway are proposed to have broad spectrum disease resistance (BSR) without yield penalties. Now we have more evidence than ever, yet little understanding about the pathway-based genes that orchestrate rapid, coordinated induction of phenylpropanoid defenses in response to microbial attack. It is not astonishing that mutants of pathway regulator genes can show conflicting results. Therefore, precise engineering of the pathway is an interesting strategy to aim at profitably tailored plants. Here, this review portrays the current progress and challenges for phenylpropanoid pathway-based resistance from the current prospective to provide a deeper understanding.

The purpose of this paper is to record and analyze induced gamma-band activity (GBA) (30−60 Hz) in cerebral motor areas during imaginary movement and to compare it quantitatively with activity recorded in the same areas during actual movement using a simplified electroencephalogram (EEG). Brain activity (basal activity, imaginary motor task and actual motor task) is obtained from 12 healthy volunteer subjects using an EEG (Cz channel). GBA is analyzed using the mean power spectral density (PSD) value. Event-related synchronization (ERS) is calculated from the PSD values of the basal GBA (GBAb), the GBA of the imaginary movement (GBAim) and the GBA of the actual movement (GBAac). The mean GBAim and GBAac values for the right and left hands are significantly higher than the GBAb value (p = 0.007). No significant difference is detected between mean GBA values during the imaginary and actual movement (p = 0.242). The mean ERS values for the imaginary movement (ERSimM (%) = 23.52) and for the actual movement (ERSacM = 27.47) do not present any significant difference (p = 0.117). We demonstrated that ERS could provide a useful way of indirectly checking the function of neuronal motor circuits activated by voluntary movement, both imaginary and actual. These results, as a proof of concept, could be applied to physiology studies, brain−computer interfaces, and diagnosis of cognitive or motor pathologies.

The desired results of increasing access and availability of antenatal care (ANC) services may not be realized if the quality of care offered is not adequate. We analyzed the content/quality of antenatal care to determine whether there are socioeconomic (education and wealth) inequalities in the services provided in 59 low and middle income countries in six WHO regions-Africa, East Asia and Pacific, Europe and Central Asia, Latin America and Caribbean, Middle East and South Asia. We aggregated the most recent (2005-2015) Demographic and Health Survey for each country. The quality of content was measured on eight recommended ANC services-(1) monitoring of blood pressure; (2) tetanus injection; (3) urine analysis for protein; (4) blood test; (5) information about danger signs (6); weight (7); height measurements and (8) provision of iron-folate supplement. Descriptive and Poisson regression techniques were applied to analyse the data. We found considerable wealth and educational differences prior to controlling for known covariates. Between wealth and education, however, the disparities in the latter are larger than the former. Whereas the socioeconomic differences remained at post adjusting for residence, place and number of antenatal care, parity and region, the magnitude of change was minimal. Higher number of ANC content was provided in "other" forms of private facilities; the Latin America and Caribbean region recorded the highest number of content compared to the other regions. The hypothesized socioeconomic status on content/number of ANC services was generally supported, although the associations are substantially constrained to other variables. Efforts are made to increase the number and timing of ANC services; due recognition is needed for the content offered.

A hybrid Fabry-Pérot cavity sensing head based on a four-bridge microstructured fiber is characterized for temperature sensing. The characterization of this cavity is performed numerically and experimentally in the L-band. The sensing head output signal presents a linear variation with temperature changes, showing a sensitivity of 12.5 pm/°C. Moreover, this Fabry-Pérot cavity exhibits good sensitivity to polarization changes and high stability over time.

El objeto del presente estudio es caracterizar el tiempo de vuelo (Tv) de la fase aérea en el ejercicio de arrancada en halterofilia. Se describe su comportamiento en función del incremento progresivo de la carga y en relación con variables biomecánicas del tirón, así como su evolución en un ciclo de entrenamiento. Se realizó un test máximo de cargas progresivas con siete halterófilos (n = 7) de competición. Mediante los sistemas de valoración Musclelab y Chronojump se registraron los valores de: fuerza (F), potencia (P), velocidad (V), pico de velocidad (pV) y altura relativa (Hrel) de la barra en el tirón, junto al Tv del desplazamiento de los pies del levantador en la entrada bajo la barra. Se observó una moderada correlación negativa (r = –0,561; p

La pretensión de este trabajo es cuestionar la interpretación más generalizada de Freud,que le atribuye un determinismo estricto. La tesis que vamos a sostener es que, aunque Freud admite un determinismo general de carácter metodológico, opuesto a arbitrariedad, que haga posible la comprensión y explicación del psiquismo, el determinismo estricto que defiende lo reduce a los nivelesinconscientes de la personalidad, de manera que no negaría un cierto grado de libertad en el ser humano.Esta libertad se concretaría en un cierto poder de la voluntad consciente y del yo para elegir, pormedio de la reflexión, en función de sus aspiraciones. Su posición, por tanto, sería una forma de compatibilismo.

An increasing number of companies engage with global markets due to technological advances, digitalisation and the homogenisation of consumers’ tastes. Taking into account the consumers’ opinion becomes more important in the current global output. On the other hand, the use of social media promotes the interaction between companies and users, and they are considered to be key elements in generating socialisation and, in addition, they contribute to generating images, communicating and improving participation. This interaction represents the moment in which value is generated in the commercial offer. In this context, the co-creation as marketing strategy is considered a very useful tool to approach the consumers and, thus, facilitate the global result, becoming social media as an important resource for management. The aim of this paper is to show the relevance of the global marketing strategy in fashion and accessories’ retail sector, as well as to study the role that companies grant to co-creation such as strategy which allows approaching consumer in those international markets. For this purpose, we will focus on Spanish firms in the fashion and accessories industry. In sum, this qualitative study, analysed using Atlas.ti® software, leads to a new paradigm which represents the transition of a brand model based on proposing solutions, proposals, and collective responses, to a business model that increasingly develops proposals, solutions and individual responses.

We propose and demonstrate the use of spatial multiplexing as a means to reduce the costs of distributed sensing networks. We propose a new scheme in which remote power-by-light switching is deployed to scan multiple branches of a distributed sensing network based on Brillouin Optical Time Domain Analysis (BOTDA) sensors. A proof-of-concept system is assembled with two 5-km sensor fiber branches that are alternatively monitored using a fast remotely controlled and optically powered optical switch. The multiplexed distributed sensor fibers were located 10 km away from the interrogation unit and a Raman pump is used to remotely power the switch. Furthermore, the deployed BOTDA unit uses an alternative configuration that can lead to simplified setups.

We report polariton lasing in localised gap states in a honeycomb lattice of coupled micropillars. Localisation of the modes is induced by the optical potential created by the excitation beam, requiring no additional engineering of the otherwise homogeneous polariton lattice. The spatial shape of the gap states arises from the interplay of the orbital angular momentum eigenmodes of the cylindrical potential created by the excitation beam and the hexagonal symmetry of the underlying lattice. Our results provide insights into the engineering of defect states in two-dimensional lattices.

A photonic crystal fiber-based sensing head is proposed for strain measurements. The sensor comprises a Hi-Bi PCF sensing head to measure interferometric signals in-reflection. An experimental background study of the sensing head is conducted through an optical backscatter reflectometer confirming the theoretical predictions, also included. A cost effective setup is proposed where a laser is used as illumination source, which allows accurate high precision strain measurements. Thus, a sensitivity of ~7.96 dB/me was achieved in a linear region of 1,200 μe.

A sensing head based on a hollow-core photonic crystal fiber for in-reflection measurement of micro-displacements is presented. The sensing structure takes advantage of the multimodal behavior of a short segment of hollow-core photonic crystal fiber in-reflection, being spliced to a single mode fiber at its other end. A modal interferometer is obtained when the sensing head is close to a mirror, through which displacement is measured.

El museo moderno nació en la segunda mitad del siglo XVIII con una ideología particular, con formas predilectas de enfrentarse al mundo y provisto de unas habilidades y unas actitudes determinadas. Como ocurre con los seres humanos, esta suerte de código genético ha condicionado en gran medida su desarrollo posterior. Es por eso que muchos de nuestros museos se siguen presentando a sí mismos como herederos incuestionables del conocimiento enciclopédico al que aspiraron los filósofos del Siglo de las Luces. Desde su fundación han cimentado su autoridad en el dominio del conocimiento y han elaborado sus relatos a partir de un modo científico de interpretar la realidad. Este artículo persigue dos objetivos: en primer lugar, analizar la naturaleza del museo como una tecnología de la Modernidad y un instrumento de legitimación de los Estados liberales; y en segundo lugar, mostrar cómo la reflexión ética puede ayudar a estas instituciones a adoptar un nuevo papel en la sociedad del conocimiento, cuestionando las bases ideológicas del paradigma occidental. Para ello se realizará un análisis situado e interdisciplinar donde se combinarán las voces de filósofos, sociólogos, antropólogos y museólogos, de los que se extraerá una propuesta de aplicación al entorno cultural iberoamericano.

This paper presents an overview of optical fiber sensor networks for remote sensing. Firstly, the state of the art of remote fiber sensor systems has been considered. We have summarized the great evolution of these systems in recent years; this progress confirms that fiber-optic remote sensing is a promising technology with a wide field of practical applications. Afterwards, the most representative remote fiber-optic sensor systems are briefly explained, discussing their schemes, challenges, pros and cons. Finally, a synopsis of the main factors to take into consideration in the design of a remote sensor system is gathered.