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INTRODUCTION: Central precocious puberty (CPP) is treated with long-acting gonadotropin releasing hormone (GnRH) analogues (GnRHa). Some adult patients undergoing GnRHa treatment experienced prolonged QT syndrome, which is associated with an increased risk of serious cardiac events, such as myocardial infarction, stroke, arrhythmias, and sudden cardiac death. METHODS: Seventy-four patients, aged between 5 and 11 years and diagnosed with CPP but with no other concomitant disease or medication use, underwent electrocardiogram (ECG) assessment. They had been receiving 3.75 mg leuprolide acetate (Lucrin® Depot) injections every 28 days for at least three months. RESULTS: The ECGs of all patients showed a corrected QT (QTc) interval within normal limits, consistent with the data for healthy Turkish children of the same age and gender. No other pathological physical examination or ECG findings were observed. Furthermore, there was no significant difference in QTc interval when adjusted for age, anthropometric data, or the duration or cumulative dose of the treatment. DISCUSSION AND CONCLUSION: The study found no correlation between QTc interval values and age, treatment duration, total cumulative dose, and anthropometric data. These findings suggest that cardiovascular adverse events associated with GnRHa treatment may be related to age and other underlying physiopathological conditions in adults rather than being directly due to the drug.

Abstract Cellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation of mutant as a platform that can concomitantly evaluate drug-target interactions and phenotypic responses using conditionally stabilized drug biosensors. We observe that drug-responsive proteotypes are prevalent among reported mutants of known drug targets. Compatible mutants appear to follow structural and biophysical logic that permits intra-protein and paralogous expansion of the biosensor pool. We then apply our method to uncouple target engagement from divergent cellular activities of MutT homolog 1 (MTH1) inhibitors, dissect Nudix hydrolase 15 (NUDT15)-associated thiopurine metabolism with the R139C pharmacogenetic variant, and profile the dynamics of poly(ADP-ribose) polymerase 1/2 (PARP1/2) binding and DNA trapping by PARP inhibitors (PARPi). Further, PARP1-derived biosensors facilitated high-throughput screening for PARP1 binders, as well as multimodal ex vivo analysis and non-invasive tracking of PARPi binding in live animals. This approach can facilitate holistic assessment of drug-target engagement by bridging drug binding events and their biological consequences.

Abstract Background Academic procrastination (AP), a common behavior among students, is influenced by factors such as fear of failure, task aversiveness, anxiety, and stress. Self-generated stress (SGS) refers to the subjective experience of tension that occurs in response to an existing situation. Individuals often overestimate the difficulty and attainability of a task, resulting in increased stress and extended stress duration. SGS can worsen mental and physical health problems, including bruxism. Therefore, this study investigates the possible underlying connections by examining the relationship between AP, SGS, and self-reported (SR) bruxism in medical and dental students. Methods The present cross-sectional study was undertaken among a sample of 379 students pursuing medical and dentistry degrees in Turkey. The questionnaire, including the Academic Procrastination Scale-Short Form, SR bruxism Scale, and SGS Scale, was administered to the students. According to the responses given to the SR bruxism Scale, 3 types of SR bruxism groups were created as sleep, awake, and compound. A comparative analysis was conducted on AP, SGS, and SR bruxism among medical and dental students. Furthermore, the associations among AP, SGS, and SR bruxism were assessed using the utilization of correlation tables and regression analysis. Results The prevalence of awake bruxism was higher among dental students (46.6%) compared to medical students (34.7%), suggesting a faculty-dependent trend. A significant positive correlation was observed between SGS and AP (r = 0.212, p

Abstract Background Maxillofacial complex automated segmentation could alternative traditional segmentation methods to increase the effectiveness of virtual workloads. The use of DL systems in the detection of maxillary sinus and pathologies will both facilitate the work of physicians and be a support mechanism before the planned surgeries. Objective The aim was to use a modified You Only Look Oncev5x (YOLOv5x) architecture with transfer learning capabilities to segment both maxillary sinuses and maxillary sinus diseases on Cone-Beam Computed Tomographic (CBCT) images. Methods Data set consists of 307 anonymised CBCT images of patients (173 women and 134 males) obtained from the radiology archive of the Department of Oral and Maxillofacial Radiology. Bilateral maxillary sinuses CBCT scans were used to identify mucous retention cysts (MRC), mucosal thickenings (MT), total and partial opacifications, and healthy maxillary sinuses without any radiological features. Results Recall, precision and F1 score values for total maxillary sinus segmentation were 1, 0.985 and 0.992, respectively; 1, 0.931 and 0.964 for healthy maxillary sinus segmentation; 0.858, 0.923 and 0.889 for MT segmentation; 0.977, 0.877 and 0.924 for MRC segmentation; 1, 0.942 and 0.970 for sinusitis segmentation. Conclusion This study demonstrates that maxillary sinuses can be segmented, and maxillary sinus diseases can be accurately detected using the AI model.

Abstract Background Sarcopenia is an age‐related muscle disease that increases the risk of falls, disabilities, and death. It is associated with increased muscle protein degradation driven by molecular signalling pathways including Akt and FOXO1. This study aims to identify genes, gene interactions, and molecular pathways and processes associated with muscle aging and exercise in older adults that remained undiscovered until now leveraging on an artificial intelligence approach called artificial neural network inference (ANNi). Methods Four datasets reporting the profile of muscle transcriptome obtained by RNA‐seq of young (21–43 years) and older adults (63–79 years) were selected and retrieved from the Gene Expression Omnibus (GEO) data repository. Two datasets contained the transcriptome profiles associated to muscle aging and two the transcriptome linked to resistant exercise in older adults, the latter before and after 6 months of exercise training. Each dataset was individually analysed by ANNi based on a swarm neural network approach integrated into a deep learning model (Intelligent Omics). This allowed us to identify top 200 genes influencing (drivers) or being influenced (targets) by aging or exercise and the strongest interactions between such genes. Downstream gene ontology (GO) analysis of these 200 genes was performed using Metacore (Clarivate™) and the open‐source software, Metascape. To confirm the differential expression of the genes showing the strongest interactions, real‐time quantitative PCR (RT‐qPCR) was employed on human muscle biopsies obtained from eight young (25 ± 4 years) and eight older men (78 ± 7.6 years), partaking in a 6‐month resistance exercise training programme. Results CHAD, ZDBF2, USP54, and JAK2 were identified as the genes with the strongest interactions predicting aging, while SCFD1, KDM5D, EIF4A2, and NIPAL3 were the main interacting genes associated with long‐term exercise in older adults. RT‐qPCR confirmed significant upregulation of USP54 (P = 0.005), CHAD (P = 0.03), and ZDBF2 (P = 0.008) in the aging muscle, while exercise‐related genes were not differentially expressed (EIF4A2 P = 0.99, NIPAL3 P = 0.94, SCFD1 P = 0.94, and KDM5D P = 0.64). GO analysis related to skeletal muscle aging suggests enrichment of pathways linked to bone development (adj P‐value 0.006), immune response (adj P‐value

Abstract Heavy metal toxicity adversely affects plants by changing physiological, biochemical, and molecular mechanisms. Lead (Pb) is one of the most common heavy metal pollutants. Hence this study investigated changes caused by exogenous methyl jasmonate (MeJA; 20 and 100 µM) and salicylic acid (SA; 2 and 20 mM) elicitors in local Karacadağ rice exposed to Pb stress (0, 100, and 400 ppm). The effects of elicitors on photosynthetic pigment content (chlorophyll a, chlorophyll b, and total carotenoid), proline, malondialdehyde (MDA), total phenolic and flavonoid, Pb, and total protein contents in stressed plants were evaluated. All parameters studied increased and decreased at varying rates in the treatment groups compared to the Pb-free group (control), indicating that rice plants were affected by Pb stress. The elicitors (MeJA, SA, and MeJA + SA) were applied by foliar spraying. The elicitor treatments increased photosynthetic pigment content, total protein, proline, total flavonoid, and phenolic contents depending on the elicitor type and concentration. MDA and Pb contents, increasing with Pb toxicity, decreased with elicitor treatments, and the stress degree was reduced. When the elicitors were compared, SA was more effective than MeJA in total flavonoid content at 400 ppm Pb toxicity. However, MeJA was more effective in photosynthetic pigment contents, MDA, total protein, Pb, total phenolic, and proline contents. The best results for all parameters examined in rice plants exposed to Pb toxicity were obtained from the 400 ppm Pb + 2 mM SA + 20 µM MeJA treatment group. In conclusion, this study showed that the combined application of MeJA + SA alleviated the harmful effects of Pb by reducing MDA and increasing photosynthetic pigments, total protein, proline, and secondary metabolites, especially at high Pb concentrations. Consequently, this study demonstrated that the combined use of MeJA and SA in rice plants eliminated the negative effects of stress quite effectively, even at high Pb concentrations. Therefore, future studies should focus on the synergistic application of different elicitors to better understand the effects of heavy metal toxicity on plant growth and development.

Objective: This research was conducted to determine students' opinions about taking the mental health and disease nursing course through distance education.Methods: The research, designed as a descriptive quantitative study, and conducted with students (n=243) taking the Mental Health and Disease Nursing course at the Nursing Department of a state university in Ankara. "Participant Information Form", " Assessment Form for Mental Health and Diseases Nursing Course Distance Education," created by the researchers, and the "Opinions About Distance Education Scale" were used to collect the data. In data analysis, content analysis was performed for open-ended questions, and the data were presented under themes, sub-themes, and categories. Number, percentage, mean, standard deviation, median, minimum, and maximum values were given for the scale scores.Results: The views of students on distance education were conceptualized under four themes: "Views on distance education", "Effectiveness of teaching methods used", ''Effectiveness of methods used in the practice skill courses, ''Preparedness for provide nursing care to patients followed up with a psychiatric diagnosis.' The total mean score of the participants for the opinions about the distance education scale was determined as 2.91±0.48.Conclusion: The students evaluated the education provided through distance education as moderately sufficient. The teaching methods used in the mental health and diseases nursing course taken through distance education and ensuring permanence through repeated access to courses were stated as positive aspects in theoretical terms, significant deficiencies were expressed in terms of contacting patients in the clinical environment and gaining professional roles.

Objective: This study aims to investigate the effect of video-assisted patient education (VPE) on knee functions, quality of life (QoL) and decrease complications in total knee replacement (TKR) patients.Methods: This study is designed as a prospective, parallel, two-arm, randomized clinical trial. It included 44 patients who underwent elective TKR at an orthopedics and traumatology clinic. The VPE group received VPE including early postoperative care for TKR, activities of daily living, and gradual exercise program in addition to the existing routine care at the clinic. The control group received only routine care. The results were collected with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short Form-36 (SF-36) scores measured at baseline, 1st and 3rd months after TKR. Results: The mean scores of the VPE group on the pain, stiffness, and physical function of the WOMAC were significantly lower in 3rd month after TKR than the control group. The VPE group had significantly higher scores than the control group on SF-36 of all subcategories except pain, emotional role, and mental health in 3rd month after TKR.Conclusion: The VPE can improve knee function and QoL in TKR patients. Nurses can use the VPE method in patients to improve knee functions and QoL after TKR.

Parental engagement, characterized by mutual expectations, dialogues about needs, comprehension of communicated messages, and proactive responsiveness, plays a pivotal role in shaping early childhood education outcomes. Collaboration between families and educational institutions is integral within the societal framework where both entities coexist. Recognizing the significance of parental engagement, this study aimed to validate and adapt the “Parent Engagement in Early Childhood Education Survey” to align with the Turkish socio-cultural and linguistic context. The study, conducted in Afyonkarahisar, Türkiye, encompassed seven kindergartens, comprising both private and public institutions. Based on convenience sampling technique, a total of 381 parents of 36–72-month-old children participated, with a predominant presence of females (88.7%). The parents’ ages primarily fell within the range of 31–35 years (40.4%), and a substantial portion held university degrees (47.2%). The confirmed three-factor structure of the adapted survey encompasses knowledge/expectations, trust/communication, and home-based engagement. Importantly, no item modifications were deemed necessary during the adaptation process. Subsequent reliability assessments indicated a commendable internal consistency value for the entire scale (α = .80), reaffirming the instrument’s reliability.

Objective: It was aimed to examine the relationship between sleep quality and anger levels of individuals with chronic obstructive pulmonary disease (COPD). Materials and Methods: This cross-sectional study was conducted with 195 individuals with COPD hospitalized in the chest diseases ward of Van Training and Research Hospital between January and August 2023. Data were collected using the Epworth sleepiness scale (ESS), Richard-Campbell sleep scale (RCSS), and state-trait anger expression ınventory (STAI). Results: The mean age of the individuals who participated in this study was 67.81 (10.59) years and were diagnosed with COPD 9.85 (9.27) years ago. There was a weakly significant positive correlation (r=0.278; p0.05). A significant negative correlation was found between the year of diagnosis of COPD, the number of COPD attacks in the last year, and the mean total score of RCSS (p

Abstract Background The experiences of GPs in Australia highlight key considerations regarding workload demands, remuneration incentives and the practical implications of working in regions with high ethnic density. This exploration helps to understand the elements that influence GPs delivery of care, particular for refugee women who exhibit disproportionately higher rates of chronic pain. This qualitative study explored the experiences of GPs providing care for refugee women living with chronic pain. Methods Semi-structured interviews were undertaken with 10 GPs (9 female and 1 male) practicing across metropolitan Melbourne, Australia. GPs were recruited via purposive sampling and a snowballing strategy. Participants work experience ranged from one to 32 years. Audio recordings of the interviews were transcribed verbatim and stored in qualitative data Nvivo 12 software for coding. Transcripts of interviews were analysed thematically using a phenomenological approach. Results Three overarching themes were identified: (1) meeting the needs of refugee women living with chronic pain; (2) the role of the GP; and (3) the challenges of the health care system. These themes reflected the complexity of consultations which arose, in part, from factors such as trust, the competencies of clinician’s and the limitations posed by time, funding and interpreter use. Conclusion GPs acknowledged the uniqueness of refugee women’s chronic pain needs and whilst doctors welcomed care, many were often challenged by the complex nature of consultations. Those that worked in settings that aligned with refugee women’s needs highlighted the importance of cultivating culturally safe clinical environments and listening to their patients’ stories. However, system level challenges such as time, funding and resource constraints created significant challenges for GPs. Exploring GPs experiences allows for a better understanding of how vectors of disadvantage intersect in health care and highlights the need to better support doctors to improve health care provision for refugee women living with chronic pain.

Purpose: The aim of this study is to evaluate the clinical and radiologic outcomes of patients with moderate to severe hallux valgus (HV) who underwent capsuloplasty and buniectomy with Lindgren-Turan osteotomy. Materials and Methods: The outcomes of 71 patients who underwent Modified Lindgren-Turan procedure were evaluated in the medium and long term. Clinically, assessment was done using the American Orthopaedic Foot and Ankle Society (AOFAS) score and Visual Analog Scale (VAS). Radiologically, preoperative and postoperative measurements of hallux val-gus angle (HVA), distal metatarsal angle (DMAA), first-second intermetatarsal angle (IMA), and first metatarsal shortening were evaluated using X-ray. Patients with moderate (n=52) and severe (n=19) hallux valgus were divided into two groups. Results: The patients were followed up for an average of 52.76 ± 9.7 months (range: 38-78 months). Patients were divided into two groups: moderate HV (group 1) and severe HV (group 2). In both groups, statistically significant improvements were observed in HVA, IMA, and DMAA values (p < 0.001). There was a shortening observed in the first metatarsal in both groups, but no significant difference was found between the groups (p = 0.342). Clinically, significant improvements were also noted in AOFAS and VAS scores in both groups (p < 0.001). Conclusion: The Modified Lindgren-Turan osteotomy causes mild shortening of the metatarsal, which does not lead to any compli-cations. With this method, moderate and severe hallux valgus deformities can be corrected, and favorable clinical and radiological outcomes can be achieved.

Abstract Background We aimed to determine the best-performing machine learning (ML)-based algorithm for predicting gestational diabetes mellitus (GDM) with sociodemographic and obstetrics features in the pre-conceptional period. Methods We collected the data of pregnant women who were admitted to the obstetric clinic in the first trimester. The maternal age, body mass index, gravida, parity, previous birth weight, smoking status, the first-visit venous plasma glucose level, the family history of diabetes mellitus, and the results of an oral glucose tolerance test of the patients were evaluated. The women were categorized into groups based on having and not having a GDM diagnosis and also as being nulliparous or primiparous. 7 common ML algorithms were employed to construct the predictive model. Results 97 mothers were included in the study. 19 and 26 nulliparous were with and without GDM, respectively. 29 and 23 primiparous were with and without GDM, respectively. It was found that the greatest feature importance variables were the venous plasma glucose level, maternal BMI, and the family history of diabetes mellitus. The eXtreme Gradient Boosting (XGB) Classifier had the best predictive value for the two models with the accuracy of 66.7% and 72.7%, respectively. Discussion The XGB classifier model constructed with maternal sociodemographic findings and the obstetric history could be used as an early prediction model for GDM especially in low-income countries.

Abstract Objectives Neuroblastoma is the most common extracranial solid tumor in childhood. YAP (Yes‐associated protein) is a highly expressed protein in NB. Nestin is an important marker of neuronal differentiation in NB. Orthodenticle homeobox (OTX) is a transcription factor and is overexpressed in blastoma‐derived tumors. The aim of this study was to examine the potential roles of YAP‐1, Nestin, and OTX‐2 proteins in prognosis and risk stratification in neuroblastoma Methods Tumor sections of 56 patients with different NB risk groups were analyzed. YAP‐1, Nestin, and OTX‐2 protein expression levels were evaluated by immunohistochemical staining in NB patient tissue samples. Results YAP‐1, Nestin, and OTX‐2 protein expression levels were evaluated together with the clinical findings of NB patients. YAP‐1 was expressed in 18% of all tissues, while Nestin was expressed in 20.4%. OTX‐2 protein expression was found in 41.1% of the NB patients. YAP‐1 was expressed in 26.9% of high‐risk and 11.5% of low‐risk patients. Nestin was expressed in 24.4% high‐risk and 33.3% low‐risk patients. OTX‐2 was expressed in 68.2% high‐risk and 60% low‐risk patients.YAP‐1 was shown to provide survival advantages among risk groups. Interpretation The findings of this study support that YAP‐1 may be a potential prognostic biomarker for staging and risk‐group assignment of NB patients. YAP‐1 expression in neuroblastoma is associated with significantly poorer survival probabilities and should be considered as a potential therapeutic target. OTX‐2 is a promising predictive biomarker candidate, but its mechanisms need further investigation in neuroblastoma, as nestin expression is not significantly linked to patient survival.

Objective: Vaccines are the most effective tools in preventing childhood infectious diseases. Parents’ knowledge and attitudes about vaccines are fundamental factors influencing vaccination rates. While there are numerous studies about mothers, research examining fathers’ knowledge and attitudes on vaccines is limited. Our study aims to assess fathers’ knowledge and attitudes about vaccines administered in our country, determine their approach to vaccination, and understand their views on vaccine hesitancy. Methods: A cross-sectional and analytical study evaluating fathers’ knowledge and attitudes about vaccines was conducted between May and July 2022 among fathers visiting the pediatric clinic. After obtaining ethical approval, fathers were administered a questionnaire covering sociodemographic information, income, education level, number of children, fathers’ vaccine attitude, knowledge level, and non-routine vaccine considerations to assess their knowledge and attitudes about vaccines. Results: While 33% of participating fathers considered their vaccine knowledge good, 14.1% didn’t know their children’s vaccines, and 23% were unaware of vaccination timing. The majority of fathers used healthcare institutions and physicians for information about vaccines. While 17.3% experienced hesitancy about vaccinating their children, none outright refused. The most common reason for vaccine hesitancy (78.1%) was the fear of vaccine side effects. As parental education levels increased, the positive attitudes of fathers towards childhood vaccinations also increased. Conclusion: Vaccination plays a crucial role in maintaining public health. Providing accurate information to families is important to reduce vaccine hesitancy and increase vaccination rates. Healthcare professionals offering reliable information is an effective factor in fostering positive attitudes toward vaccines and increasing vaccination rates.

Virtual prototyping combined with additive manufacturing technologies are opening new horizons in healthcare and biomimetic medical device personalisation is becoming feasible and competitive. Finite element-based optimisation combined with metallic additive manufacturing has already demonstrated the physical prototyping of interesting topologies for innovative articular prostheses. However, metallic implants are biomechanically and biologically suboptimal and a shift to ceramic materials, for bone replacement and articular implants, could result interesting. To this end, challenges liked to the engineering design of large-sized topology optimised ceramic implants and their additive manufacture still need to be overcome and exemplified. Accordingly, the whole engineering design of innovative short stem hip prostheses is presented here. Different approaches to the virtual prototyping of massive ceramic implants, involving strategies for their topology optimisation, are tested and systematically compared from biomechanical and mechanobiological perspectives. After virtual validation, the selected alternatives are successfully prototyped employing lithography-based ceramic manufacturing of alumina-toughened zirconia, which constitutes a design-enabled manufacturing breakthrough considering the massive implants achieved. Non-destructive evaluation using X-ray computed tomography allows for quantitative quality control and defect detection. Summarising, the study provides a systematic knowledge-based methodology for the engineering of topology optimised ceramic implants for critically sized defects with remarkable biomechanical and mechanobiological performance.

In this study, we purpose to ensure optical soliton solutions of the nonlinear Schrödinger equation having parabolic and anti-cubic (AC) laws with a weakly non-local nonlinearity by using the new Kudryashov method. As far as we know this model has not been presented and studied before. Furthermore, what differs this study from other studies is, not only obtains a variety of analytical solutions of the examined model but also substantiates the effects of the parabolic and anti-cubic laws with a weakly non-local nonlinearity on soliton behaviour, by choosing the particular soliton forms, which are dark, bright and W-like. Eventually, we depict some of the derived solutions in contour, 2D and 3D diagrams selecting the appropriate values of parameters by means of Matlab to demonstrate the importance of the given model. It is indicated that parabolic and AC parameters taking into consideration the weak non-local contribution have a very remarkable impact on the soliton structure, and the impact alters connected with the parameters and the soliton form. Besides, enabling and retaining the critical balance between the parameters and the soliton form and the interactive relation of the parameters with each other comprises major challenges.

This action research aimed to enhance the curriculum knowledge of 37 pre-service teachers in early-childhood education through backward design (BD) as an innovative framework. Participants enrolled in an online curriculum development course focusing on curriculum elements and underwent BD-based instruction for five weeks. Multiple data collection tools were employed, including pre- and post-achievement tests and curriculum literacy scales, digital learning journals, performance tasks, course observations, and interviews. The results showed a significant improvement in the curriculum knowledge of the pre-service teachers. This was evidenced by a notable increase in curriculum literacy scores, a moderate improvement in achievement test scores, and positive performance task outcomes. These findings highlight the effectiveness of BD-based instruction in enhancing the curriculum knowledge of pre-service teachers. This study provides valuable insights for teacher educators to effectively tailor their instructional approaches. Further research is needed to validate these results and advance instructional practices in pre-service teacher education.

The increasing competition and rapid technological advancements in today's business world have raised customer expectations. People now expect quick delivery, low prices, and high-quality products. As a result, companies must adapt to this competitive environment to survive. Rework, which is a significant cost in production, increases expenses, reduces production efficiency, and can lead to customer attrition. Research shows various efforts across different sectors to reduce rework, although there is still a gap in the textile sector's fabric dyeing units. Common problems in these units include non-retentive colors, customer dissatisfaction with shades, and repeated dyeing due to environmental factors or dye vat issues. This study uses logistic regression and artificial neural networks models from machine learning to predict which fabrics will need rework, using data from a textile company in Bursa. The analysis indicates that artificial neural networks models perform better.

Aim: According to delivery room guidelines, an optimal position is not specified for the stabilization of the baby. This study aimed to define the positions effects on postnatal adaptation parameters and cerebral oxygenation in non-resuscitated neonates. Materials and Methods: A total of 60 neonates delivered by cesarean section stabilized randomly in the supine, right-side, left-side, or prone positions were enrolled. Apgar scores, heart rates (HR), arterial oxygen saturations via pulse oximetry, and perfusion indexes (PI) at the 2nd, 5th and 10th minutes were recorded. Cerebral regional oxygen saturation (SpO2) of the patients was monitored by near-infrared spectroscopy. Results: In the prone position, the 1st minute Apgar score was significantly lower than other groups, but no difference was observed at the 5th minute Apgar scores (1st min Apgarprone, p=0.05). Although there was no statistically significant difference, the prone position had the lowest HR at the 2nd minute, while the supine posture had the greatest HR at the 5th and 10th minutes. While the groups’ SpO2 values were similar, the left-side group’s perfusion rates increased at the 5th and 10th minute marks (5th and 10th min PIleft-side, p=0.67, p=0.21, respectively). Regional cerebral oxygen saturation (rScO2) and cerebral fractional oxygen extraction did not differ significantly between groups at the 5th and 10th minute time intervals. Although right and left rScO2 were found to be higher in the first 5 minutes in the prone position, this elevation did not lead to a statistically significant difference, and right and left rScO2 values were found to be similar in all groups at the 10th minute. Conclusion: Adaptation parameters were not affected by position, except for lower 1st minute Apgar scores in the prone group and higher perfusion indices in the left lateral position. Cerebral perfusion was similar in all groups. The left-side position, which results in a higher PI, may be a good alternative. Studies with larger case series may provide further information.

Abstract Fuzzy sets (FSs) are a flexible and powerful tool for reasoning about uncertain situations that cannot be adequately expressed by classical sets. However, these sets fall short in two areas. The first is the reliability of this tool. Z-numbers are an extension of fuzzy numbers that improve the representation of uncertainty by combining two important components: restriction and reliability. The second is the problems that need to be solved simultaneously. Complex fuzzy sets (CFSs) overcome this problem by adding a second dimension to fuzzy numbers and simultaneously adding connected elements to the solution. However, they are insufficient when it comes to problems involving these two areas. We cannot express real-life problems that need to be solved at the same time and require the reliability of the information given with any set approach given in the literature. Therefore, in this study, we propose the complex fuzzy Z-number set (CFZNS), a generalization of Z-numbers and CFS, which fills this gap. We provide the operational laws of CFZNS along with some properties. Additionally, we define two essential aggregation operators called complex fuzzy Z-number weighted averaging (CFZNWA) and complex fuzzy Z-number weighted geometric (CFZNWG) operators. Then, we present an illustrative example to demonstrate the proficiency and superiority of the proposed approach. Thus, we process multiple fuzzy expressions simultaneously and take into account the reliability of these fuzzy expressions in applications. Furthermore, we compare the results with the existing set operations to confirm the advantages and demonstrate the efficiency of the proposed approach. Considering the simultaneous expression of fuzzy statements, this study can serve as a foundation for new aggregation operators and decision-making problems and can be extended to many new applications such as pattern recognition and clustering.

Objective: We aimed to analyze the knowledge level of surgical residents regarding preoperative assessment and increase their collaboration with other teams in optimizing the general medical status of patients to reduce the duration of hospital stay and complication rates. Method: Our study included 80 surgical residents. The 2018 update of the European Society of Anesthesiology (ESA) was used during the preparation of the survey questions. The questions were categorized on the basis of the specific clinical conditions and medications noted in the ESA guidelines. Answer choices were “correct”, “wrong” or “no idea.” Results: Analysis of the distribution of the mean correct answer rates (%) revealed that the question regarding “herbal medications” led to the lowest correct answer (13.75%), whereas the category “bridging and anticoagulation” was associated with the highest (72.5%) correct answer. The total mean correct answer was calculated as 50.8%. There was no significant correlation between the residents’ seniority level (i.e., postgraduate year) and their correct answer rates in the neurosurgery, general surgery, ear-nose-throat, and plastic surgery divisions. However, there were statistically significant differences in the ophthalmology, urology, orthopedic surgery, and obstetrics and gynecology divisions. Conclusion: The general medical status of patients should be optimized to reduce the risk of complications. To achieve this goal, surgical residents should collaborate with other teams at each perioperative stage. In addition, we suggest that the curriculum be reviewed to increase the knowledge level of surgical residents regarding preoperative care.

Abstract In this work, we demonstrate that a simple argentometric titration is a scalable, fast, green and robust approach for producing AgCl/antibiotic hybrid antimicrobial materials. We titrated AgNO3 into tetracycline hydrochloride (TCH) aqueous solution, thus forming AgCl/TCH in a one-step procedure. Furthermore, we investigated the one-pot synthesis of triply synergistic super-nanoantimicrobials, combining an inorganic source of Ag+ ions (AgCl), a disinfecting agent (benzyl-dimethyl-hexadecyl-ammonium chloride, BAC) and a molecular antibiotic (tetracycline hydrochloride, TCH). Conventional antimicrobial tests, industrial biofilm detection protocols, and in situ IR-ATR microbial biofilm monitoring, have been adapted to understand the performance of the synthesized super-nanoantimicrobial. The resulting hybrid AgCl/BAC/TCH nanoantimicrobials are found to be synergistically active in eradicating Salmonella enterica and Lentilactobacillus parabuchneri bacteria and biofilms. This study paves the way for the development of a new class of super-efficient nanoantimicrobials that combine relatively low amounts of multiple active species into a single (nano)formulation, thus preventing the development of antimicrobial resistance towards a single active principle.

BACKGROUND: Different organs respond differently to cisplatin (CDDP)-induced toxicity. Oleuropein (OLE) is a natural phenolic antioxidant. The purpose of this study was to determine the potential protective effect of OLE against CDDP-induced ototoxicity by evaluating expression of genes associated with deoxyribonucleic acid (DNA) damage and repair in cochlear cells. METHODS: House Ear Institute-Organ of Corti 1 (HEI-OC1) cells were treated using CDDP, OLE, and OLE–CDDP. The water-soluble tetrazolium salt assay was used for monitoring cell viability. Deoxyribonucleic acid damage in cells due to the CDDP, OLE, and combination treatments was determined using a flow-cytometric kit. The change in the expression of 84 genes associated with CCDP, OLE, and OLE–CDDP treatments that induced DNA damage was tested using the reverse transcription polymerase chain reaction array. Changes ≥3-fold were considered significant. RESULTS: House Ear Institute-Organ of Corti 1 cell viability was significantly reduced by CDDP. The OLE–CDDP combination restored the cell viability. Cisplatin increased the H2AX ratio, while OLE–CDDP combination decreased it. Some of the DNA damage-associated genes whose expression was upregulated with CDDP were downregulated with OLE–CDDP, while the expression of genes such as Gadd45g and Rev1 was further downregulated. The expression of DNA repair-related Abl1, Dbd2, Rad52, and Trp53 genes was downregulated with CDDP, whereas their expression was upregulated with OLE–CDDP treatment. CONCLUSION: In cochlear cells, the OLE–CDDP combination downregulated DNA damage-associated gene expression relative to that upregulated mainly by CDDP. The results revealed that OLE has a potential protective effect on CDDP-induced ototoxicity in cochlear cells by altering the expression of DNA damage-related genes.

Mechanical properties (tensile strength (TS), modulus of elasticity in tensile (MET), flexural strength (FS), modulus of elasticity (MOE)) of the material to be obtained depending on the production parameters in the production of high-density polyethylene (HDPE) wood-polymer composites with Scots pine wood flour additive were predicted using Artificial Neural Networks (ANN) model and without destructive testing. In the first stage of the study, an ANN model was developed using data from 56 different studies in the literature on the mechanical properties of wood polymer composites. In the second stage, in order to determine the reliability of the model, output values were estimated using input parameters that had not been used in training and testing of the model. Based on the same input parameters, test specimens were produced and mechanical tests were performed. The results obtained from the experiments and ANN model were compared by considering the mean absolute percentage error (MAPE) value. The coefficient of determination (R2) values obtained in the training and testing phase of the ANN models were all higher than 0.90. In this way, the mechanical properties of the wood polymer composite were successfully predicted by the ANN model. Because most of the MAPE values obtained from the mechanical tests were below 10%, the model was considered a reliable model.

Mechanical properties (tensile strength (TS), modulus of elasticity in tensile (MET), flexural strength (FS), modulus of elasticity (MOE)) of the material to be obtained depending on the production parameters in the production of high-density polyethylene (HDPE) wood-polymer composites with Scots pine wood flour additive were predicted using Artificial Neural Networks (ANN) model and without destructive testing. In the first stage of the study, an ANN model was developed using data from 56 different studies in the literature on the mechanical properties of wood polymer composites. In the second stage, in order to determine the reliability of the model, output values were estimated using input parameters that had not been used in training and testing of the model. Based on the same input parameters, test specimens were produced and mechanical tests were performed. The results obtained from the experiments and ANN model were compared by considering the mean absolute percentage error (MAPE) value. The coefficient of determination (R2) values obtained in the training and testing phase of the ANN models were all higher than 0.90. In this way, the mechanical properties of the wood polymer composite were successfully predicted by the ANN model. Because most of the MAPE values obtained from the mechanical tests were below 10%, the model was considered a reliable model.

Introduction: Our study aimed to investigate the prevalence of overweight/obesity and factors that may be associated with obesity in preschool children. Materials and Methods: The study is a descriptive cross-sectional study. All children between the ages of 4 and 6 years attending relevant educational institutions were included in the study. The height, weight, waist circumference and hip circumference of 822 children were measured and 556 of the questionnaires were completed and included in the study. Our questionnaire included questions on socio-demographic characteristics and the Quality Index of the Mediterranean Diet in Children(KIDMED scale). The data were analyzed in the SPSS package, and logistic regression models were created with the variables found to be significant after univariate analysis. P≤0.05 was considered statistically significant. Results: Of the participants, 68(12.3%) were overweight and 28(5%) were obese. When analyzing the overweight/obesity status, it was observed that the frequency of being overweight/obese was higher in males(p=0.05), children whose mothers were obese(p

Purpose: This paper investigates the determinants of labor productivity of Turkish manufacturing sectors by taking into account both the global value chain (GVC) participation and the research and development (R&D) expenditure for the period of 1995-2018. Methodology: To analyze the determinants of labor productivity in Turkish manufacturing sectors, we specify the labor productivity model and estimate this empirical model by the Ordinary Least Squares (OLS) and Two-Stage Least Squares (2SLS) methods. Findings: Our estimation results indicate that while simple forward GVC participation enhances the labor productivity of Turkish high-tech manufacturing sectors if they trade with developing countries, complex forward GVC participation increases productivity regardless of trading partners. For low-tech sectors, there is no significant impact of GVCs or R&D on productivity. There is no significant impact of backward GVC participation and sectoral R&D intensity on labor productivity. These significant results provide strong evidence for the importance of deeper involvement of high-tech sectors in GVCs for higher sectoral productivity. Given the strong heterogeneity in terms of sectors and trading partners, specific policies should be targeted to benefit from the productivity gains of the global value chains. Originality: This study contributes to the current studies by focusing on disaggregated measures of GVC participation indices and enlarges the empirical analysis by considering the heterogeneity in trading partners (developed and developing trading partners).

Abstract Background Acute hypoxic proximal tubule (PT) injury and subsequent maladaptive repair present high mortality and increased risk of acute kidney injury (AKI) - chronic kidney disease (CKD) transition. Human bone marrow mesenchymal stem cell-derived exosomes (hBMMSC-Exos) as potential cell therapeutics can be translated into clinics if drawbacks on safety and efficacy are clarified. Here, we determined the real-time effective dose and treatment window of allogeneic hBMMSC-Exos, evaluated their performance on the structural and functional integrity of 3D microfluidic acute hypoxic PT injury platform. Methods hBMMSC-Exos were isolated and characterized. Real-time impedance-based cell proliferation analysis (RTCA) determined the effective dose and treatment window for acute hypoxic PT injury. A 2-lane 3D gravity-driven microfluidic platform was set to mimic PT in vitro. ZO-1, acetylated α-tubulin immunolabelling, and permeability index assessed structural; cell proliferation by WST-1 measured functional integrity of PT. Results hBMMSC-Exos induced PT proliferation with ED50 of 172,582 µg/ml at the 26th hour. Hypoxia significantly decreased ZO-1, increased permeability index, and decreased cell proliferation rate on 24–48 h in the microfluidic platform. hBMMSC-Exos reinforced polarity by a 1.72-fold increase in ZO-1, restored permeability by 20/45-fold against 20/155 kDa dextran and increased epithelial proliferation 3-fold compared to control. Conclusions The real-time potency assay and 3D gravity-driven microfluidic acute hypoxic PT injury platform precisely demonstrated the therapeutic performance window of allogeneic hBMMSC-Exos on ischemic AKI based on structural and functional cellular data. The novel standardized, non-invasive two-step system validates the cell-based personalized theragnostic tool in a real-time physiological microenvironment prior to safe and efficient clinical usage in nephrology.

Amaç: Bu çalışma, bipolar bozukluk hastalarının başa çıkma stratejileri ile işlevsellik düzeyleri arasındaki ilişkiyi belirlemeyi amaçlamaktadır. Yöntemler: Bu çalışma tanımlayıcı ve ilişki arayıcı bir çalışmadır. Çalışma, Mart 2017-Ocak 2018 tarihleri arasında Doğu Anadolu Bölgesi'ndeki bir hastanenin psikiyatri polikliniğine başvuran bipolar bozukluk tanılı hastalar ile yapılmıştır. Bulgular: Bu çalışmada FAST puanı ortalaması ile “duygulara odaklanma ve dışa vurma”, “madde kullanımı”, “kabullenme”, “yarışmacı etkinlikleri bastırma”, “dine yönelme”, “inkar”, “ davranışsal ilgiyi kesme, olumlu yeniden yorumlama, duygusal sosyal desteği kullanma ve planlama arasında pozitif yönde anlamlı bir ilişki bulunmuştur. Sonuç: Hastaların kullandıkları başa çıkma stratejilerinin işlevsellik düzeylerinde etkili olduğu görülmüştür.

A consistent increase in the installation of distributed generation (DG) in response to rising energy cost and demand throughout the world, especially for the last two decades, primarily aims to obviate upgrading investments for transmission and distribution lines on the existing power grid while ensuring sustainable, resilient, and reliable service to end users. Random installation of DG, on the other hand, can invalidate the existing grid’s designated objectives, and operational boundaries due to the changes in network topology resulting in unforeseen load flow. Appropriate integration of DG units on DC networks should be remedy to high transmission/distribution losses in lines, instabilities in voltage profiles, issues in power quality parameters, and derogation in the protection schemes. Based on the behavior of load profiles, e.g., 24 h or longer period, operational and technical constraints, this study proposes a framework that minimizes transmission/distribution losses on a DC network, in which discrete variables stand for the location of DGs. Optimal power flow (OPF) problem formulation underpins the proposed optimization framework. Overall, this computationally challenging planning problem refers to a mixed-integer nonlinear program (MINLP) including discrete variables with non-convex power balance/flow representations. To deal with the non-convexities and discrete form of the formulation, a mixed-integer second-order cone programming (MISOCP) relaxation, and branch-and-bound search are assigned. The validation of the introduced approach is carried out on the IEEE modified benchmark systems. With the help of proposed method, optimal allocation of DG units on 9-bus, 14-bus, and 30-bus systems, respectively, lead up to 99.93%, 94.38%, and 79.09% total power losses reduction.

Abstract Objectives Prolonged intubation is a known risk factor of LTS. LTS related to COVID‐19 may result in a different phenotype: pronation affects the location of stenosis and COVID‐19 pneumonia can decline lung mechanics. Therefore, airway management in these patients may carry unique challenges for both anesthesiologists and surgeons. This prospective observational feasibility trial aims to evaluate the use of a novel thin, cuffed, endotracheal tube (Tritube) in combination with flow‐controlled ventilation (FCV) in the management of patients with COVID‐19‐related LTS undergoing laryngeal surgery. Methods 20 patients suffering from COVID‐19‐related LTS, as diagnosed by CT, requiring endolaryngeal surgery, with or without CO2 laser, were included. Ultrathin endotracheal tube Tritube, together with FCV was used for airway management and ventilation. Feasibility, ventilation efficiency, and surgical exposure were evaluated. Results Median duration of mechanical ventilation during their ICU stay was 17 days, (range, 7–27), and all patients had been pronated. In 18/20 patients, endoscopic diagnosis confirmed the initial CT diagnosis: posterior subglottic stenosis. Surgeons’ satisfaction on the view was rated 9 out of 10 (range 7–10), where 0 was the worst view and 10 was the best view. Hemodynamic and respiratory variables were within the normal clinical range during the surgical procedure. One patient that had a SpO2 of 90% before induction of anesthesia, a temporal drop to 89%, caused meeting the predefined requirement of “respiratory complication.” Conclusion This study demonstrates the feasibility of using Tritube with FCV in patients with relatively unusual subglottic posterior location tracheal stenosis, undergoing laryngotracheal surgery. Tritube provides a good surgical field and FCV provides highly adequate ventilation especially in patients with compromised lung mechanics. Level of Evidence IV, non‐comparitive prospective clinical trial with 20 patients.

Abstract This manuscript aims to present new results about the generalized F-contraction of Hardy–Rogers-type mappings in a complete vector-valued metric space, and to demonstrate the fixed-point theorems for single and pairs of generalized F-contractions of Hardy–Rogers-type mappings. The established results represent a significant development of numerous previously published findings and results in the existing body of literature. Furthermore, to ensure the practicality and effectiveness of our findings across other fields, we provide an application that demonstrates a unique solution for the semilinear operator system within the Banach space.

In this paper, we aim to overcome the problem given by Abkar et al. [Abstr. Appl. Anal., 2013 (2013), 189567], and so to obtain real generalizations of fixed point results in the literature. In this direction, we introduce a new class of functions, which include $ \mathcal{R} $-functions. Thus, we present a new type of $ \mathcal{R} $ -contraction and weaken $ \mathcal{R} $-contractions that have often been studied recently. We also give a new definition of the $ P $-property. Hence, we obtain some best proximity point results, including fixed point results for the new kind of $ \mathcal{R} $-contractions. Then, we provide an example to show the effectiveness of our results. Finally, inspired by a nice and interesting technique, we investigate the existence of a best proximity point of the homotopic mappings with the help of our main result.

In this paper, we elucidate a pivotal fixed point theorem for $ P $-contraction mappings defined on $ M $-metric spaces, offering a novel perspective on the interplay between mappings and the underlying space structure. This theorem's significance becomes evident when compared with earlier results, underscoring its potential to enhance our understanding of fixed point theory in $ M $-metric spaces and its broader applications.

Objective: Anisakis simplex is a fish-borne zoonotic parasite. Although this parasite has been known since the 19th century, publications on anisakiasis have increased in recent years. Despite this, this subject has yet to be well studied by bibliometric analysis. This study was conducted to show the research points and trends of A. simplex. Methods: The Web of Science Core Collection (WoSCC) was mined for articles on A. simplex. The VOSviewer software visually evaluated countries, institutions, authors, references, and keywords in this field. Results: A total of 1362 publications were included in this bibliometric analysis. The included publications were published between 1970 and 2022 from 79 countries, mainly from Spain (n=456, 33.48%). The most prolific year was 2020 (n=74). The research area that attracted the most publications was parasitology (n=452), while the most productive author in this area was Cuellar C (n=53). “Anisakis simplex”, “Anisakis” and “anisakiasis” were the most used three keywords. Conclusion: The number of publications on anisakiasis has been increasing over time, suggesting that A. simplex is becoming an increasingly important disease worldwide. Research cooperation should be established between researchers from developed and developing countries to determine effective control strategies for anisakiasis.

Plants produce secondary metabolites for defense against herbivorous insects. In this study, the effects of different concentrations of quinine, nicotine, and tannic acid on food consumption and pupal parameters of the larva of a severe pest, Malacosoma neustria L. (Lepidoptera: Lasiocampidae), were investigated in 2007. Artificial diets containing 0.125%, 0.25%, and 0.5% concentrations of quinine or nicotine were prepared. In addition, diets containing 1.25%, 2.5%, and 5% tannin and a control diet without secondary metabolite were prepared. The feeding experiments revealed that the food consumption and pupal parameters of male and female larvae were different, and all parameters of female individuals were higher than those of male larvae. It has been determined that tannins cause more reductions in food consumption and pupal parameters than alkaloids in male and female individuals. We observed an increase in male larvae's pupal mass with increased concentration of nicotine to 0.5%. Nicotine did not cause a decrease in pupal parameters of larvae compared to quinine. In addition, all parameters of female individuals decreased with the addition of secondary metabolite. Although food consumption in alkaloid-containing diets was less than in the control group, there was a positive relationship between food consumption and pupal lipid and protein content. However, quinine had a more significant effect on triggering protein storage than nicotine. In diets containing tannins, more lipids were stored. A decrease was observed in the food consumption and pupal parameters of all individuals in the tannin-containing diets compared to the other diets.

It is crucial to understand the experiences of academics in their early years to learn their perspectives, thoughts, and actions. In this comparative research, the authors aim to explore how informal mentoring works in Kazakhstani and Turkish higher education and wish to contribute to implementing a formal faculty mentoring program at the university as a means for young academics’ professional growth and career development. This comparative study sheds light on the similarities and differences in the practice of mentoring within two distinct contexts. It revealed commonalities in terms of the current state of mentoring and the challenges faced by mentees.

OBJECTIVE: A 1-day point prevalence study was planned to obtain country data by determining the clinical characteristics, follow-up and treatment methods of coronavirus disease 2019 (COVID-19) cases that required intensive care unit (ICU) treatment in the second year of the pandemic. MATERIAL AND METHODS: All patients who were hospitalized in the ICUs due to COVID-19 between March 11, 2022, 08.00 am, and March 12, 2022, 08.00 am, were included in the study. Demographic characteristics, intensive care and laboratory data, radiological characteristics, and follow-up results of the patients were recorded. RESULTS: A total of 811 patients from 59 centers were included in the study, 59% of the cases were male, and the mean age was 74 ± 14 years. At least one comorbid disease was present in 94% of the cases, and hypertension was the most common. When ICU weight scores were examined, Acute Physiology and Chronic Health Evaluation-II: 19 (15-27) and Sequential Organ Failure Assessment: 7 (4-10) were seen. Sepsis was present in 37% (n = 298) of cases. PaO2/FiO2 ratios of the patients were 190 the highest and 150 the lowest and 51% of the cases were followed via invasive mechanical ventilation. On the study day, 73% bilateral involvement was seen on chest x-ray, and ground-glass opacities (52%) were the most common on chest tomography. There was growth in culture in 40% (n = 318) of the cases, and the most common growth was in the tracheal aspirate (42%). CONCLUSION: The clinical course of COVID-19 is variable, and ICU follow-up was required due to advanced age, comorbidity, presence of respiratory symptoms, and widespread radiological involvement. The need for respiratory support and the presence of secondary infection are important issues to be considered in the follow-up. Despite the end of the second year of the pandemic and vaccination, the high severity of the disease as well as the need for follow-up in ICUs has shown that COVID-19 is an important health problem.

Regarding the dynamics of the contemporary world economy, success in a domestic economy cannot be achieved without effective integration policies for goods/services and capital flows. To evaluate this proposition, we utilize many openness measures for two periods, 1995-2009 and 2000-2014, for the Turkish sectors. The empirical findings suggest that domestic value added in export is a major driver of sectoral value added. While import and backward linkages appear to be stimulators for total factor productivity (TFP) in manufacturing industries, they have no significant impact on sectoral value added. Trade barriers in the form of tariff rates, which primarily stemmed from manufacturing industries, have a considerable detrimental impact on Turkish sectoral performance. Higher tariffs not only make it more difficult for Turkish businesses to enter overseas markets but also raise the costs for importers. The initial impact of this protection is inexorably exacerbated by global value chains (GVCs), with negative consequences felt in nearly every economy. Given the increased backward GVC involvement of some manufacturing industries, such as machinery and equipment, Turkish sectors should be prepared for external shocks by diversifying importer origins, stocking up, and boosting transparency in their operations. Overall, designing and implementing trade policies to effectively integrate into the GVCs is an important task for Turkey.

This research paper investigated fixed point results for almost ($ \zeta-\theta _{\rho } $)-contractions in the context of quasi-metric spaces. The study focused on a specific class of ($ \zeta -\theta _{\rho } $)-contractions, which exhibit a more relaxed form of contractive property than classical contractions. The research not only established the existence of fixed points under the almost ($ \zeta -\theta _{\rho } $)-contraction framework but also provided sufficient conditions for the convergence of fixed point sequences. The proposed theorems and proofs contributed to the advancement of the theory of fixed points in quasi-metric spaces, shedding light on the intricate interplay between contraction-type mappings and the underlying space's quasi-metric structure. Furthermore, an application of these results was presented, highlighting the practical significance of the established theory. The application demonstrated how the theory of almost ($ \zeta -\theta _{\rho } $)-contractions in quasi-metric spaces can be utilized to solve real-world problems.

Emotion recognition is a crucial aspect of human–computer interaction, particularly in the field of marketing and advertising. Call centers play a vital role in generating positive client experiences and maintaining relationships. As individuals increasingly rely on computers for daily tasks, there is a growing need to improve human–computer interactions. Research has been conducted on emotion recognition, in three main areas: facial expression-based, voice-based, and text-based. This study focuses on emotion recognition on incoming customer calls to call centers, which plays a vital role in customer experience and company satisfaction. The study uses real-life customer data provided by Turkish Mobile Operators to analyze the customer’s emotional state and inform call center employees about the emotional state. The model created in this research is a significant milestone for sentiment analysis in the Turkish language, demonstrating the ability to acquire fundamental patterns and categorize emotional expressions. The objective is to analyze the emotional condition of individuals using audio data received from phone calls, focusing on identifying good, negative, and neutral emotional states. Deep learning techniques are employed to analyze the results, with an accuracy value of 0.91, which is acceptable for our partner the “Turkcell Global Bilgi Pazarlama Danışmanlık ve Çağrı Servisi Hizmetleri” Incorporation.

Objective: Children with cleft lip and palate (CLP) have a greater risk of dental caries. The parents’ knowledge and attitudes may have an impact on their children’s oral health and dietary habits. Therefore, the aim of this study was to assess the socio-demographic characteristics, oral health knowledge, oral health behaviours, and habits of the parents in addition to the relationship with the oral health and dietary practices of their children with CLP. Material and methods: The parents of 343 patients with CLP participated in the study. An online questionnaire with 52 questions regarding sociodemographic characteristics, oral health and oral hygiene practices was presented to them. Results: Parents with higher level of education had better oral health knowledge (p

This scoping review prepared by endocrinology and nephrology experts aimed to address the significance of finerenone, as a novel therapeutic option, in diabetic kidney disease (DKD), based on the biological prospect of cardiorenal benefit due to non-steroidal mineralocorticoid receptor antagonist (MRA) properties, and the recent evidence from the finerenone phase 3 program clinical trials. The importance of finerenone in slowing DKD progression was critically reviewed in relation to the role of MR overactivation in the pathogenesis of cardiorenal disease and unmet needs in the current practice patterns. The efficacy and safety outcomes of finerenone phase III study program including FIDELIO-DKD, FIGARO-DKD and FIDELITY were presented. Specifically, perspectives on inclusion of patients with preserved estimated glomerular filtration rate (eGFR) or high albuminuria, concomitant use of sodium-glucose co-transporter-2 inhibitor (SGLT2i) or glucagon-like peptide 1 receptor agonist (GLP-1 RA), baseline glycated hemoglobin (HbA1c) level and insulin treatment, clinically meaningful heart failure outcomes and treatment-induced hyperkalemia were addressed. Finerenone has emerged as a new therapeutic agent that slows DKD progression, reduces albuminuria and risk of cardiovascular complications, regardless of the baseline HbA1c levels and concomitant treatments (SGLT2i, GLP-1 RA, or insulin) and with a favorable benefit-risk profile. The evolving data on the benefit of SGLT2is and non-steroidal MRAs in slowing or reducing cardiorenal risk seem to provide the opportunity to use these pillars of therapy in the management of DKD, after a long-period of treatment scarcity in this field. Along with recognition of the albuminuria as a powerful marker to detect those patients at high risk of cardiorenal disease, these important developments would likely to impact standard-of-care options in the setting of DKD.

We present the case of a patient with X-Linked Hypophosphatemia (XLH) and an inflammatory myofibroblastic tumor (IMT) of the bladder which prompted further investigation into the possible relationship between XLH and IMT i.e. a case of Occam's Razor or Hickam's Dictum?

Understanding which factors influence exchange rate movements is important for understanding economic development, trade patterns, investment decisions, and for designing economic policies. In this study, we allow for monetary, domestic and global financial variables to assess the relevant importance of each of the variables to exchange rate volatility in the case of Turkey. The paper investigates the dynamics of exchange rate volatility of the Turkish lira in a complementary perspective by employing both Generalized autoregressive conditional heteroskedasticity (GARCH) method and Lyapunov exponents over the period from March 1, 2019 to November 11, 2021. Firstly, decomposing the impact of domestic and global financial variables, the results of the GARCH model indicate that the exchange rate volatility is affected by Volatility index (VIX) and Credit default swaps (CDS). This result suggests that the exchange rate shocks experienced are mainly caused by global factors, therefore policymakers should focus on volatility spillovers caused by global financial markets. Secondly, detected positive maximal Lyapunov exponent shows that complexity in foreign exchange markets has been increased, market expectations lead to multiple-equilibria and diverging volatility eventually will generate recurrent spikes in currency value. These complementary findings have important implications for interventions of Central banks and preventing systemic risks, as well as portfolio and risk management. JEL Classification: C32, G14, G15.

Adil yargılanma hakkı hem Türkiye’de hem de dünyada ülkelerin yargı erkinin en çok eleştiriye maruz bırakıldığı, Avrupa İnsan Hakları Sözleşmesi’nin (AİHS) 6. maddesinde güvence altına alınmış oldukça kapsamlı bir haktır. Bu hak, soruşturma aşamasından başlayarak olağan ve olağanüstü kanun yolları dâhil kovuşturma aşamasının sonuna kadar tüm yargılama sürecini kapsamaktadır. Adil yargılanma hakkı sadece ceza hukukuna özgü değildir. Bu hak, hukuk yargılaması ve idari soruşturmalar ile disiplin organları tarafından yapılan işlemleri de güvence altına alır. Hukuka aykırı delillerin adil yargılanma hakkı yönünden değerlendirilmesini amaçlayan bu çalışmada, hukuka aykırı delillerin yargılamada kullanılması konusu insan hakları hukuku yanında ceza hukuku yönünden de incelenmektedir. Çalışmada adil yargılanma hakkı ve “hukuka aykırı delil” konusu ulusal mevzuat ve AİHS hükümleri ile Avrupa İnsan Hakları Mahkemesi (AİHM) içtihatları yönünden incelenmektedir. Ayrıca hukuka aykırı delil kullanımı bakımından AİHM’nin oldukça tartışılan Gäfgen - Almanya kararı değerlendirilmektedir.

Today, the changes that occur with aging are met negatively in most of the societies in the world, and elderly individuals are exposed to discrimination. This study aimed to examine the relationship of nursing students' attitudes towards elderly individuals and their levels of compassion with the factors influential on them. The study is of descriptive and cross-sectional type. The study was carried out with the 2nd grade, 3rd grade, and 4th-grade nursing students (n:508). In the study, the independent variables with a statistically significant relationship with the dependent variables were subjected to the stepwise multiple linear regression analysis. The students' mean scores were 48.85±5.00 on the UCLA geriatric attitude scale and 99.17±10.98 on the compassion scale. It was found that compassion, willingness to work with elderly individuals after graduation, the place the elderly person should stay in (in a nursing home, in their own home), perceived compassion fatigue level (mild), father's education level (undergraduate level and above), and problems experienced in social relations with elderly individuals were significant predictors of the nursing students’ attitudes towards elderly individuals. It was revealed that nursing students’ positive attitudes towards elderly individuals increased as their levels of compassion increased. It was seen that the students who had a mild level of compassion fatigue and who wanted to work with elderly individuals after graduation had more positive attitudes. Moreover, it was found that the students who thought that elderly individuals should stay in a nursing home or in their own home, whose father's education level was undergraduate level and above, and who had problems in social relations with elderly individuals had more negative attitudes. Educators, nursing students, nurses, and administrators can make use of the findings of this study so that they can develop appropriate strategies to improve attitudes toward elderly individuals. Keywords: Today, the changes that occur with aging are met negatively in most of the societies in the world, and elderly individuals are exposed to discrimination. This study aimed to examine the relationship of nursing students' attitudes towards elderly individuals and their levels of compassion with the factors influential on them. The study is of descriptive and cross-sectional type. The study was carried out with the 2nd grade, 3rd grade, and 4th-grade nursing students (n:508). In the study, the independent variables with a statistically significant relationship with the dependent variables were subjected to the stepwise multiple linear regression analysis. The students' mean scores were 48.85±5.00 on the UCLA geriatric attitude scale and 99.17±10.98 on the compassion scale. It was found that compassion, willingness to work with elderly individuals after graduation, the place the elderly person should stay in (in a nursing home, in their own home), perceived compassion fatigue level (mild), father's education level (undergraduate level and above), and problems experienced in social relations with elderly individuals were significant predictors of the nursing students’ attitudes towards elderly individuals. It was revealed that nursing students’ positive attitudes towards elderly individuals increased as their levels of compassion increased. It was seen that the students who had a mild level of compassion fatigue and who wanted to work with elderly individuals after graduation had more positive attitudes. Moreover, it was found that the students who thought that elderly individuals should stay in a nursing home or in their own home, whose father's education level was undergraduate level and above, and who had problems in social relations with elderly individuals had more negative attitudes. Educators, nursing students, nurses, and administrators can make use of the findings of this study so that they can develop appropriate strategies to improve attitudes toward elderly individuals.

MAP is the causative agent of paratuberculosis and has also been implicated in the etiology of Crohn's Disease in humans. Therefore, the importance of studies on this subject increases as MAP causes many economic losses by causing disease in cattle and is important for public health. The aim of this paper was to map the global scientific landscape related to MAP research. The WOS database was queried for publications bearing the title "Mycobacterium avium subsp. paratuberculosis" during January 2001-December 2021 employing the R bibliometrix program. A total of 1775 articles were reviewed in this bibliometric analysis. Notably, the majority of these articles originated from the USA (n = 536, 30.541%). The year 2013 emerged as the most productive year for publications. In terms of research fields, veterinary science (n = 730, 41.6%) was the leading research area. These studies were conducted by a diverse array of researchers, including veterinarians, physicians, and other experts working to define MAP. The sustained increase in the number of publications on paratuberculosis underscores the ongoing global interest in this factor. The determination of effective control strategies for paratuberculosis is important for the food sector and public health. Therefore, a research collaboration between countries should be established in this regard.

The possibilities of using organic wastes, such as hazelnut shells (HS), walnut shells (WS), hazelnut skins (HzS), and spent mushroom compost (SMC), as growth medium in cut flower rose cultivation in soilless substrate culture were investigated. The parameters, such as the date of cutting the flower (day), flower stem length (cm), flower stem diameter (mm), flower length (cm), flower diameter (cm), flower color, color of the top and bottom of the leaf, and yield (piece), were examined. In addition, samples taken from the growth medium at the beginning and ending stages of the experiment were analyzed. The first flowers were cut from the HzS +P medium 38 days after planting. The highest yield value (20.6 flower/plant) was obtained from SMC medium. The longest flowers (63.89 ± 0.947 cm) and the thickest stem flowers (5.86 ± 0.136 mm) were cut from the control medium. It was determined that the media also affected the flower and leaf colors. According to the results obtained, SMC and HzS+perlite mediums can be recommended as an alternative to cocopeat in the production of cut roses in soilless substrate culture.