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The synthesis of bicyclic heterocycles, notably nitrogen-containing imidazopyridines, holds immense appeal due to their structural diversity and pivotal role in biological systems. These compounds are ubiquitously found in nature and are prized for their significance in both chemical and biological contexts. Imidazopyridine derivatives, among nitrogen heterocycles, serve as fundamental structures in various applications spanning pharmaceuticals to food additives. Consequently, their synthesis and modification represent a focal point in both natural and synthetic organic chemistry. This review aims to comprehensively explore conventional methodologies alongside innovative synthesis approaches, while also delving into the diverse biological properties exhibited by these versatile heterocycles. Through this examination, we endeavor to provide valuable insights that will contribute to further advancements in the synthesis and utilization of imidazopyridines in various fields.

The increasing incidence of fraud in the olive oil market, particularly through adulteration with cheaper oils, poses a major challenge for the industry. This study examines the effectiveness of fluorescence spectroscopy combined with chemometric tools as a method to detect and quantify olive oil adulteration. Chemical analyses were used to measure parameters such as specific absorption coefficients K232 and K270, peroxide value, and acidity, in accordance with International Olive Council (IOC) standards. These measurements were conducted on samples of olive oil blended with varying percentages of adulterating oils. 3D fluorescence spectra were analyzed to examine the changes induced by adulteration. The results show that free acidity and peroxide value decrease with increasing adulteration degree, while the parameters K232 and K270 increase with the degree of adulteration. Principal component analysis (PCA) was effectively used to differentiate samples based on the percentage of adulterant. A partial least squares (PLS) regression model was developed, achieving a correlation coefficient of 0.999 for predicting the percentage of adulterant in olive oil. This PLS model also proved effective in predicting oil quality parameters such as free acidity and K232 and K270 indices. The results of this study demonstrate the significant potential of fluorescence spectroscopy as a rapid and non-destructive method for olive oil authentication. PCA emerges as a powerful tool for characterizing pure oils without requiring sample preparation or destruction. Furthermore, PLS models provide accurate means to predict both the presence of adulterants and olive oil quality parameters. This approach offers a promising solution to combat fraud in the olive oil industry, ensuring product integrity and quality.

The qualitative and quantitative analysis aims to identify secondary metabolites, including phenolic compounds, alkaloids, terpenes, and other substances commonly referred to as phytochemicals. Qualitative phytochemical screening relies on color and precipitation tests that indicate the presence or absence of a metabolite, while quantitative analysis accounts for the quantity or concentration of the bioactive compounds contained within the extracts. During the quantitative determination of the total content of phenolics and flavonoids present in the extracts, we used the conventional soxhlet extraction (SE) method with solvents of different polarities. The purpose of this study is to ascertain the impact of solvents with varying polarity on both the extraction yield and phytochemical composition of A. unedo leaves. The findings indicate that yield and polyphenol content vary from one extract to another. Thus, the ethanol extract (EEAU) showed the highest percentage extraction yield (15.23%) and the highest total phenolic content (TPC) with 122.82 ± 5.42 mg GAE/gext. In contrast, the dichloromethane extract (EDAU) had the lowest extraction yield (1.76%), while the methanol extract (EMAU) showed the highest total flavonoid content (TFC) with 45.8 ± 1.3 mg QE/gext. Generally, these data provide information into the phytochemical content of various extracts of the plant growing in the Ait Ammart region. These extracts contain several bioactive substances that will be useful in the formulation of pharmaceutical products for a variety of diseases and may have applications in the food industry.

Imidazopyridine and its derivatives are essential heterocycles widely utilized in medicinal chemistry, natural products, and synthetic chemicals. The unique structural characteristics of the imidazopyridine ring facilitate their interaction with various enzymes and receptors through weak interactions, leading to a wide range of biological and pharmacological effects. Many imidazole derivatives are extensively used in clinical practice to treat various diseases, highlighting their significant potential for further research. This review provides a comprehensive synthesis of current research on imidazopyridine or imidazopyridine derivatives in medicinal chemistry, focusing on their roles as anti-inflammatory, anticancer, antiviral, antibacterial, and other therapeutic agents.

This mini review delves into the critical need to effectively eliminate nitrates, nitrites, phosphates, and ammonium from wastewater to mitigate environmental pollution and uphold water quality standards. Stemming from various human activities like agricultural runoff, industrial processes, and municipal discharges, these pollutants pose significant risks to both aquatic ecosystems and human health if left unaddressed. The study primarily focuses on the efficacy of coagulation-flocculation as a treatment method, which involves the addition of chemicals known as coagulants to destabilize the pollutants. The review further examines the influence of various parameters such as pH, coagulant dosage, and temperature on the simultaneous removal of these contaminants [1,2]. Through detailed analysis, it elucidates the complex interactions among these factors and their consequential impact on overall removal efficiency. Moreover, it underscores the significance of adopting advanced treatment methods like coagulation-flocculation. Additionally, it emphasizes the ongoing need for further research and optimization to address the evolving challenges of wastewater pollution and water resource management comprehensively. By providing insights into optimizing coagulation-flocculation processes, this review underscores the importance of tailored treatment strategies for comprehensive pollutant removal.

Amoxicillin’s prevalence in aquatic environments, stemming from widespread medical usage, serves as a significant indicator of pharmaceutical contamination. Adsorption stands out as the preferred method for addressing this issue due to its simplicity, efficacy, practicality, and cost-effectiveness. This systematic review delves into peer-reviewed literature on amoxicillin removal through adsorption, drawing from databases like ScienceDirect and Scopus. Researchers have investigated adsorption equilibrium under varied conditions, exploring parameters such as pH, temperature, and adsorbent dosage. The diverse range of observed elimination levels underscores the critical importance of careful adsorbent selection, with capacities spanning from 10 to 1500 mg/g. Pseudo-second-order kinetic models and the Langmuir isotherm model frequently offer suitable descriptions of experimental data. Future research avenues could explore alternative kinetic models to deepen our understanding of amoxicillin adsorption mechanisms and foster the development of innovative adsorbents.

Medicinal plants serve as a significant source of bioactive molecules, with their utilization in the medical realm dating back to ancient times through herbal preparations. In Morocco, the utilization of plants remains integral to traditional medicine. Despite numerous studies documenting indigenous knowledge regarding plant use, scant attention has been given to northern Morocco, particularly the Rif region. This study seeks to enrich and consolidate our understanding of plant utilization in this area. The ethnobotanical investigation was centred on medicinal plants employed in cosmetics within northern Morocco. A questionnaire was disseminated, gathering data encompassing plant names, utilized plant parts, and preparation methods. The study identified 32 plant species utilized in cosmetics, including Cannabis sativa L., Dittrichia viscosa (L.) Greuter, Juglans regia L., and Rubus fruticosus L. Leaves emerged as the most used plant parts, with decoction and infusion being the predominant preparation methods. This survey facilitated a comprehensive examination of ethnobotanical knowledge, shedding light on the primary plants employed in cosmetics. Prudent management of these resources is imperative to prevent future shortages.

Cannabis sativa subsp. sativa L. is an industrial plant that has gained importance due to its essential oil (EO), which has commercial, medical, and potential cosmetic applications. Despite its significance, the chemical constituents of the C. sativa EO cultivated in Morocco is not well understood. In this context, the current study aimed to define and analyze the volatile fraction and evaluate the antioxidant capacity of the plant C. sativa EO for the first time in the Al-Hoceima province in northern Morocco. To assess its chemical composition, gas chromatography-mass spectrometry (GC-MS) was utilized after hydrodistillation using a Clevenger-style apparatus. The analysis revealed that caryophyllene, α-humulene, and β-myrcene were the major constituents, accounting for 31.77%, 11.21%, and 8.76% of the EO, respectively. Antioxidant activity results indicate that the potency of C. sativa EO is interesting (IC50 = 4.45 mg/mL) for the DPPH● (2,2-diphenyl-1-picrylhydrazyl) test. These findings indicate that the C. sativa EO may serve as a natural source of antioxidants.

A simple, solvent-free, and field-compatible approach to sample preparation is provided by the basic process known as solid-phase micro extraction (SPME). The aim of this study was to improve the circumstances under which triazines were extracted from aqueous matrices. The complex technique enabled the detection of the analytes in the water at a physiological level. An evaluation of the practicability of the most commercially available fiber coatings has been conducted. The porous materials (Carbowax/DVB and PDMS/DVB) extracted more efficiently than homogeneous ones (PDMS and polyacrylate). Further investigation has been focused on 65 mm PDMS/DVB fiber. Solid phase microextraction is a technique based on the partition equilibrium of analytes between the sample and the fiber. Therefore, 60 minutes were required to reach equilibrium at room temperature. The desorption efficiency at 3 temperature levels had been compared and 270 °C was retained. Experiments were performed with a Finnigan MAT GCQ Model installed with a 30-m x 0.32-mm ID, ZB-5 (0.25-mm film thickness) fused-silica capillary column, and Helium as a carrier gas (at 30 kPa), The ion trap mass spectrometer was operated in the electron ionization (EI) mode. Keywords: Fiber coating, Gaz chromatography, Mass spectrometry, Pesticides, Water matrices, Analysis.

The composition of leachates is very variable and rich in toxic compounds, which requires treatment before discharge into the natural environment in order to avoid their impact on the environment and/or human health and to comply with the requirements of regulatory discharge standards in the natural environment. Among the parameters indicating pollution by leachates, we have COD, BOD5, conductivity, pH, the presence of ammonium ions, nitrite, nitrate, chloride, orthophosphate, etc. This study presents the results of synthetic leachate orthophosphate adsorption tests on bentonite clays. For the determination of the orthophosphate concentration in the synthetic leachate, before and after adsorption, we applied the method of Ultra-Violet adsorption spectroscopy. The adsorption capacity of bentonite, the amount needed and the removal efficiency were determined. The orthophosphate adsorption yield on bentonite reaches up to 32.6 % for 5 g/L of bentonite stirred for 4 hours and exceeds 39,19 % after 24 hours of stirring.

Emerging organic micropollutants, such as bisphenol A (BPA), have raised concerns about their negative impact on human health and ecological safety. This review article aims to demonstrate and highlight recent advances in adsorption applications for bisphenol A, a toxic environmental pollutant commonly found in wastewater. There are many reasons to use non-toxic materials and eco-friendly technologies to remove this pollutant from sewage. [1] Several adsorbents previously used have shown significant efficiency and performance for the removal of BPAs, and current research is directed towards the development of low-cost treatment processes using materials such as clays and Chitosan. The properties of the adsorbent can be adjusted by changing their surface for an optimized performance. In addition, the efficiency of the adsorption process depends on various parameters such as solution pH, the pollutant concentration, contact time, temperature, nature and dose of the adsorbent, which are also discussed. In addition, we critically review the isothermal, kinetic and thermodynamic approaches. [2]

Due to population growth and the intensification of economic activity, the production of solid waste is constantly increasing in Morocco [1]. Several programs consist of the establishment of controlled landfills and the rehabilitation of uncontrolled landfills. The impact of landfilling is the production of liquid effluents rich in organic, mineral, and metallic matter called leachate [2,3]. The choice of leachate treatment is based on the characteristics of the leachate. Any treatment process has advantages and limitations, so before proceeding with the treatment it is necessary to characterize the leachate to choose the appropriate process [11]. The objective of this study is to prepare synthetic leachate based on the characteristics of real leachate (case of the controlled landfill of Al Hoceima), in order to carry out treatability tests of this synthetic leachate by controlling the various parameters of analysis. This solution was made from organic (CH3CO2H, CH3CO2Na) and inorganic compounds (MgSO4, CaCl2, Ca(OH)2, NH4Cl, KOH, MgCl2), the various analyzes of this solution gave values comparable to the real solution. This work was devoted to carrying out the treatability tests of synthetic leachate by a process of adsorption on bentonite, by studying its yield to reduce the organic load.