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Alexander C Lieu,1,2 Benton G Chuter,1,2 Niloofar Radgoudarzi,1,2 Evan H Walker,2 John H Huang,2 Nathan L Scott,2 Natalie A Afshari2 1School of Medicine, University of California San Diego, La Jolla, CA, USA; 2Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, CA, USACorrespondence: Natalie A Afshari, University of California, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, 9415 Campus Point Drive, La Jolla, San Diego, CA, 92037, USA, Tel +1-858-534-6290, Email naafshari@health.ucsd.eduPurpose: To study geographic patterns of supply and demand for uveal melanoma and other ocular oncology healthcare by ocular oncology physicians in the United States.Methods: Google search interest data was obtained through trends.google.com. The combined-state density of ocular oncology physicians was calculated by dividing the number of practicing ocular oncologists in each state and its surrounding states by the state population. Relative search volume (RSV) values were divided by ocular oncology physician density to calculate the Google relative demand index (gRDI) for each state. Medicare (mRDI) and IRIS® Registry (iRDI) relative demand indices were calculated using prevalence data obtained through the Vision and Eye Health Surveillance System (VEHSS). Data from the US Census Bureau and Centers for Disease Control (CDC) databases were also utilized to analyze associations with poverty rates, percent living in urban or rural areas, vision screening rates, and ocular neoplasm rates.Results: Alabama showed the highest RSV (100), while the lowest was reported in New Mexico (20). Vermont had the highest density of combined-state ocular oncology ophthalmologists (1.85 per 100,000 residents). New Mexico had the lowest RDI (0.013 gRDI, 0.015 mRDI, 0.018 iRDI) with 32 combined-state ocular oncologists and a population of 2,114,371. Ocular neoplasm prevalence rates ranged between 1.32% and 5.40% and significantly correlated with RSV. Single-state gRDI correlated with rural status and negatively correlated with urban areas (≥ 50,000 individuals). Single-state ophthalmologist density correlated positively with percent living in urban areas and vision screening rates, and negatively with rural status.Conclusion: This study uncovered significant heterogeneity in the geographical distribution of ocular oncology physicians and RDI throughout the United States, highlighting potential undersupply scenarios. This may guide efforts to increase ocular oncology physician and surgeon availability in areas of need.Keywords: ocular oncology, google trends, medicare, IRIS® Registry, uveal melanoma

The interval of time after pouring concrete is an important factor, which directly affects the timing and cost of construction. The case study that was investigated in this research, is a tunnel project located in Iran. Eighteen mix designs were prepared using properties such as different water-cement ratios and the use of two types of superplasticizer with different dosages. The optimal mix designs among the samples were separately specified.