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Abstract The objective of this work was to simultaneously select pre-commercial grain sorghum hybrids with high adaptability and yield stability, through mixed modeling, in 20 environments, during six years. The evaluated plant material consisted of 57 commercial grain sorghum hybrids. In all experiments, hybrids were arranged in a triple lattice design; some experiments used a 6x6 lattice, and others, a 5x5 lattice. Adaptability and stability parameters were obtained based on the prediction by harmonic mean of the relative performance of genotypic values (HMRPGV). The mixed models proved to be adequate to analyze the genotype x environment (GxE) interaction and the genotypic adaptability and stability studies on grain sorghum. The hybrids that stand out, considering all environments are 1G282, A9904, 50A50, A9902, and XB6022. The A9904 hybrid stands out in favorable environments, with a grain yield above average. Only 1G282 is among the five best hybrids for each group of environments, and it is the best grain sorghum hybrid for yield performance, adaptability, and stability. The predicted genotypic values based on genotypic means can be used in the environments with the same GxE interaction pattern because they are free of the GxE interaction.